| Year |
Citation |
Score |
| 2019 |
Papaconstantinou J. The Role of Signaling Pathways of Inflammation and Oxidative Stress in Development of Senescence and Aging Phenotypes in Cardiovascular Disease. Cells. 8. PMID 31689891 DOI: 10.3390/Cells8111383 |
0.38 |
|
| 2019 |
Neelakantan H, Brightwell CR, Graber TG, Maroto R, Wang HL, McHardy SF, Papaconstantinou J, Fry CS, Watowich SJ. Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle. Biochemical Pharmacology. PMID 30753815 DOI: 10.1016/J.Bcp.2019.02.008 |
0.304 |
|
| 2016 |
Cortez I, Bulavin DV, Wu P, McGrath EL, Cunningham KA, Wakamiya M, Papaconstantinou J, Dineley KT. AGED DOMINANT NEGATIVE p38α MAPK MICE ARE RESISTANT TO AGE-DEPENDENT DECLINE IN ADULT-NEUROGENESIS AND CONTEXT DISCRIMINATION FEAR CONDITIONING. Behavioural Brain Research. PMID 27765672 DOI: 10.1016/J.Bbr.2016.10.023 |
0.348 |
|
| 2016 |
German P, Saenz D, Szaniszlo P, Aguilera-Aguirre L, Pan L, Hegde ML, Bacsi A, Hajas G, Radak Z, Ba X, Mitra S, Papaconstantinou J, Boldogh I. 8-oxoguanine DNA glycosylase1-driven DNA repair -a paradoxical role in lung aging. Mechanisms of Ageing and Development. PMID 27343030 DOI: 10.1016/J.Mad.2016.06.009 |
0.36 |
|
| 2016 |
Sheller S, Papaconstantinou J, Urrabaz-Garza R, Richardson L, Saade G, Salomon C, Menon R. Amnion-Epithelial-Cell-Derived Exosomes Demonstrate Physiologic State of Cell under Oxidative Stress. Plos One. 11: e0157614. PMID 27333275 DOI: 10.1371/Journal.Pone.0157614 |
0.327 |
|
| 2016 |
Al-Lahham R, Deford JH, Papaconstantinou J. Mitochondrial-generated ROS down regulates insulin signaling via activation of the p38MAPK stress response pathway. Molecular and Cellular Endocrinology. 419: 1-11. PMID 26454089 DOI: 10.1016/J.Mce.2015.09.013 |
0.315 |
|
| 2015 |
Papaconstantinou J, Hsieh CC. IGF-1 mediated phosphorylation of specific IRS-1 serines in Ames dwarf fibroblasts is associated with longevity. Oncotarget. 6: 35315-23. PMID 26474286 DOI: 10.18632/Oncotarget.6112 |
0.302 |
|
| 2015 |
Brobey RK, German D, Sonsalla PK, Gurnani P, Pastor J, Hsieh CC, Papaconstantinou J, Foster PP, Kuro-O M, Rosenblatt KP. Klotho Protects Dopaminergic Neuron Oxidant-Induced Degeneration by Modulating ASK1 and p38 MAPK Signaling Pathways. Plos One. 10: e0139914. PMID 26452228 DOI: 10.1371/Journal.Pone.0139914 |
0.359 |
|
| 2012 |
Lee JS, Ward WO, Ren H, Vallanat B, Darlington GJ, Han ES, Laguna JC, DeFord JH, Papaconstantinou J, Selman C, Corton JC. Meta-analysis of gene expression in the mouse liver reveals biomarkers associated with inflammation increased early during aging. Mechanisms of Ageing and Development. 133: 467-78. PMID 22704917 DOI: 10.1016/J.Mad.2012.05.006 |
0.425 |
|
| 2011 |
Baregamian N, Song J, Papaconstantinou J, Hawkins HK, Evers BM, Chung DH. Intestinal mitochondrial apoptotic signaling is activated during oxidative stress. Pediatric Surgery International. 27: 871-7. PMID 21400030 DOI: 10.1007/S00383-011-2880-X |
0.34 |
|
| 2010 |
Papaconstantinou J, Hsieh CC. Activation of senescence and aging characteristics by mitochondrially generated ROS: how are they linked? Cell Cycle (Georgetown, Tex.). 9: 3831-3. PMID 20890113 DOI: 10.4161/Cc.9.19.13324 |
0.408 |
|
| 2009 |
Baregamian N, Song J, Bailey CE, Papaconstantinou J, Evers BM, Chung DH. Tumor necrosis factor-alpha and apoptosis signal-regulating kinase 1 control reactive oxygen species release, mitochondrial autophagy, and c-Jun N-terminal kinase/p38 phosphorylation during necrotizing enterocolitis. Oxidative Medicine and Cellular Longevity. 2: 297-306. PMID 20716917 DOI: 10.4161/Oxim.2.5.9541 |
0.342 |
|
| 2009 |
Papaconstantinou J. Insulin/IGF-1 and ROS signaling pathway cross-talk in aging and longevity determination. Molecular and Cellular Endocrinology. 299: 89-100. PMID 19103250 DOI: 10.1016/J.Mce.2008.11.025 |
0.341 |
|
| 2008 |
Choksi KB, Nuss JE, Deford JH, Papaconstantinou J. Age-related alterations in oxidatively damaged proteins of mouse skeletal muscle mitochondrial electron transport chain complexes. Free Radical Biology & Medicine. 45: 826-38. PMID 18598756 DOI: 10.1016/J.Freeradbiomed.2008.06.006 |
0.401 |
|
| 2008 |
Choksi KB, Papaconstantinou J. Age-related alterations in oxidatively damaged proteins of mouse heart mitochondrial electron transport chain complexes. Free Radical Biology & Medicine. 44: 1795-805. PMID 18331850 DOI: 10.1016/J.Freeradbiomed.2008.01.032 |
0.426 |
|
| 2008 |
Nuss JE, Choksi KB, DeFord JH, Papaconstantinou J. Decreased enzyme activities of chaperones PDI and BiP in aged mouse livers. Biochemical and Biophysical Research Communications. 365: 355-61. PMID 17996725 DOI: 10.1016/J.Bbrc.2007.10.194 |
0.433 |
|
| 2007 |
Choksi KB, Roberts LJ, DeFord JH, Rabek JP, Papaconstantinou J. Lower levels of F2-isoprostanes in serum and livers of long-lived Ames dwarf mice. Biochemical and Biophysical Research Communications. 364: 761-4. PMID 17964285 DOI: 10.1016/J.Bbrc.2007.10.100 |
0.402 |
|
| 2007 |
Choksi KB, Nuss JE, Boylston WH, Rabek JP, Papaconstantinou J. Age-related increases in oxidatively damaged proteins of mouse kidney mitochondrial electron transport chain complexes. Free Radical Biology & Medicine. 43: 1423-38. PMID 17936188 DOI: 10.1016/J.Freeradbiomed.2007.07.027 |
0.764 |
|
| 2006 |
Boylston WH, DeFord JH, Papaconstantinou J. Identification of longevity-associated genes in long-lived Snell and Ames dwarf mice. Age (Dordrecht, Netherlands). 28: 125-44. PMID 19943135 DOI: 10.1007/S11357-006-9008-6 |
0.766 |
|
| 2006 |
Hsieh CC, Papaconstantinou J. Thioredoxin-ASK1 complex levels regulate ROS-mediated p38 MAPK pathway activity in livers of aged and long-lived Snell dwarf mice. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 259-68. PMID 16449798 DOI: 10.1096/Fj.05-4376Com |
0.427 |
|
| 2005 |
Papaconstantinou J, Deford JH, Gerstner A, Hsieh CC, Boylston WH, Guigneaux MM, Flurkey K, Harrison DE. Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice. Mechanisms of Ageing and Development. 126: 692-704. PMID 15888324 DOI: 10.1016/J.Mad.2005.01.002 |
0.777 |
|
| 2004 |
Hsieh CC, Papaconstantinou J. Akt/PKB and p38 MAPK signaling, translational initiation and longevity in Snell dwarf mouse livers. Mechanisms of Ageing and Development. 125: 785-98. PMID 15541773 DOI: 10.1016/J.Mad.2004.07.008 |
0.383 |
|
| 2004 |
Boylston WH, Gerstner A, DeFord JH, Madsen M, Flurkey K, Harrison DE, Papaconstantinou J. Altered cholesterologenic and lipogenic transcriptional profile in livers of aging Snell dwarf (Pit1dw/dwJ) mice. Aging Cell. 3: 283-96. PMID 15379852 DOI: 10.1111/J.1474-9728.2004.00115.X |
0.774 |
|
| 2004 |
Vyatkina G, Bhatia V, Gerstner A, Papaconstantinou J, Garg N. Impaired mitochondrial respiratory chain and bioenergetics during chagasic cardiomyopathy development. Biochimica Et Biophysica Acta. 1689: 162-73. PMID 15196597 DOI: 10.1016/J.Bbadis.2004.03.005 |
0.33 |
|
| 2004 |
Madsen MA, Hsieh CC, Boylston WH, Flurkey K, Harrison D, Papaconstantinou J. Altered oxidative stress response of the long-lived Snell dwarf mouse. Biochemical and Biophysical Research Communications. 318: 998-1005. PMID 15147972 DOI: 10.1016/J.Bbrc.2004.04.126 |
0.757 |
|
| 2004 |
Garg N, Gerstner A, Bhatia V, DeFord J, Papaconstantinou J. Gene expression analysis in mitochondria from chagasic mice: alterations in specific metabolic pathways. The Biochemical Journal. 381: 743-52. PMID 15101819 DOI: 10.1042/Bj20040356 |
0.375 |
|
| 2004 |
Choksi KB, Boylston WH, Rabek JP, Widger WR, Papaconstantinou J. Oxidatively damaged proteins of heart mitochondrial electron transport complexes. Biochimica Et Biophysica Acta. 1688: 95-101. PMID 14990339 DOI: 10.1016/J.Bbadis.2003.11.007 |
0.751 |
|
| 2003 |
Gangneux C, Daveau M, Hiron M, Derambure C, Papaconstantinou J, Salier JP. The inflammation-induced down-regulation of plasma Fetuin-A (alpha2HS-Glycoprotein) in liver results from the loss of interaction between long C/EBP isoforms at two neighbouring binding sites. Nucleic Acids Research. 31: 5957-70. PMID 14530444 DOI: 10.1093/Nar/Gkg788 |
0.338 |
|
| 2003 |
Szczesny B, Hazra TK, Papaconstantinou J, Mitra S, Boldogh I. Age-dependent deficiency in import of mitochondrial DNA glycosylases required for repair of oxidatively damaged bases. Proceedings of the National Academy of Sciences of the United States of America. 100: 10670-5. PMID 12960370 DOI: 10.1073/Pnas.1932854100 |
0.396 |
|
| 2003 |
Garg N, Popov VL, Papaconstantinou J. Profiling gene transcription reveals a deficiency of mitochondrial oxidative phosphorylation in Trypanosoma cruzi-infected murine hearts: implications in chagasic myocarditis development. Biochimica Et Biophysica Acta. 1638: 106-20. PMID 12853116 DOI: 10.1016/S0925-4439(03)00060-7 |
0.368 |
|
| 2003 |
Hsieh CC, Rosenblatt JI, Papaconstantinou J. Age-associated changes in SAPK/JNK and p38 MAPK signaling in response to the generation of ROS by 3-nitropropionic acid. Mechanisms of Ageing and Development. 124: 733-46. PMID 12782417 DOI: 10.1016/S0047-6374(03)00083-6 |
0.431 |
|
| 2003 |
Rabek JP, Boylston WH, Papaconstantinou J. Carbonylation of ER chaperone proteins in aged mouse liver. Biochemical and Biophysical Research Communications. 305: 566-72. PMID 12763031 DOI: 10.1016/S0006-291X(03)00826-X |
0.768 |
|
| 2002 |
Hsieh CC, Papaconstantinou J. The effect of aging on p38 signaling pathway activity in the mouse liver and in response to ROS generated by 3-nitropropionic acid. Mechanisms of Ageing and Development. 123: 1423-35. PMID 12425949 DOI: 10.1016/S0047-6374(02)00084-2 |
0.437 |
|
| 2002 |
Hsieh CC, DeFord JH, Flurkey K, Harrison DE, Papaconstantinou J. Effects of the Pit1 mutation on the insulin signaling pathway: implications on the longevity of the long-lived Snell dwarf mouse. Mechanisms of Ageing and Development. 123: 1245-55. PMID 12020946 DOI: 10.1016/S0047-6374(02)00037-4 |
0.325 |
|
| 2002 |
Hsieh CC, DeFord JH, Flurkey K, Harrison DE, Papaconstantinou J. Implications for the insulin signaling pathway in Snell dwarf mouse longevity: a similarity with the C. elegans longevity paradigm. Mechanisms of Ageing and Development. 123: 1229-44. PMID 12020945 DOI: 10.1016/S0047-6374(02)00036-2 |
0.352 |
|
| 2002 |
Kuninger DT, Izumi T, Papaconstantinou J, Mitra S. Human AP-endonuclease 1 and hnRNP-L interact with a nCaRE-like repressor element in the AP-endonuclease 1 promoter. Nucleic Acids Research. 30: 823-9. PMID 11809897 DOI: 10.1093/Nar/30.3.823 |
0.736 |
|
| 2001 |
Xiong W, Hsieh CC, Kurtz AJ, Rabek JP, Papaconstantinou J. Regulation of CCAAT/enhancer-binding protein-β isoform synthesis by alternative translational initiation at multiple AUG start sites Nucleic Acids Research. 29: 3087-3098. PMID 11452034 DOI: 10.1093/Nar/29.14.3087 |
0.342 |
|
| 2001 |
Saito H, Papaconstantinou J. Age-associated Differences in Cardiovascular Inflammatory Gene Induction during Endotoxic Stress Journal of Biological Chemistry. 276: 29307-29312. PMID 11382779 DOI: 10.1074/Jbc.M103740200 |
0.385 |
|
| 2001 |
Flurkey K, Papaconstantinou J, Miller RA, Harrison DE. Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production Proceedings of the National Academy of Sciences of the United States of America. 98: 6736-6741. PMID 11371619 DOI: 10.1073/Pnas.111158898 |
0.383 |
|
| 2001 |
Moon SK, Thompson LJ, Madamanchi N, Ballinger S, Papaconstantinou J, Horaist C, Runge MS, Patterson C. Aging, oxidative responses, and proliferative capacity in cultured mouse aortic smooth muscle cells American Journal of Physiology - Heart and Circulatory Physiology. 280. PMID 11356636 DOI: 10.1152/Ajpheart.2001.280.6.H2779 |
0.407 |
|
| 2001 |
Yiangou M, Scott SG, Rabek JP, An MR, Xiong W, Papaconstantinou J. Effects of mercuric chloride on the regulation of expression of the acute phase response components α1-acid glycoprotein and C/EBP transcription factors Biochimica Et Biophysica Acta - Gene Structure and Expression. 1518: 47-56. PMID 11267658 DOI: 10.1016/S0167-4781(01)00165-8 |
0.409 |
|
| 2001 |
Wang E, Marcotte R, Papaconstantinou HT, Papaconstantinou J. Commitment signalling for apoptosis, or DNA repair and its relevance to aging and age-dependent diseases Advances in Cell Aging and Gerontology. 4: 153-189. DOI: 10.1016/S1566-3124(01)04032-9 |
0.305 |
|
| 1999 |
Rabek JP, Papaconstantinou J. Interference mapping of nuclear protein binding to the acute phase response element of the mouse α1 acid glycoprotein gene Biochemical and Biophysical Research Communications. 255: 608-613. PMID 10049758 DOI: 10.1006/Bbrc.1999.0240 |
0.357 |
|
| 1998 |
Rabek JP, Scott S, Hsieh CC, Reisner PD, Papaconstantinou J. Regulation of LPS-mediated induction of C/EBPδ gene expression in livers of young and aged mice Biochimica Et Biophysica Acta - Gene Structure and Expression. 1398: 137-147. PMID 9689913 DOI: 10.1016/S0167-4781(98)00038-4 |
0.465 |
|
| 1998 |
Zador IZ, Hsieh CC, Papaconstantinou J. Renal CCAAT/enhancer-binding proteins in experimental diabetes mellitus Nephron. 79: 312-316. PMID 9678432 DOI: 10.1159/000045055 |
0.308 |
|
| 1998 |
Hsieh CC, Xiong W, Xie Q, Rabek JP, Scott SG, An MR, Reisner PD, Kuninger DT, Papaconstantinou J. Effects of age on the posttranscriptional regulation of CCAAT/enhancer binding protein alpha and CCAAT/enhancer binding protein beta isoform synthesis in control and LPS-treated livers. Molecular Biology of the Cell. 9: 1479-94. PMID 9614188 DOI: 10.1091/Mbc.9.6.1479 |
0.755 |
|
| 1998 |
Yiangou M, Paraskeva E, Hsieh CC, Markou E, Victoratos P, Scouras Z, Papaconstantinou J. Induction of a subgroup of acute phase protein genes in mouse liver by hyperthermia Biochimica Et Biophysica Acta - Gene Structure and Expression. 1396: 191-206. PMID 9540835 DOI: 10.1016/S0167-4781(97)00188-7 |
0.406 |
|
| 1997 |
Toliver-Kinsky T, Papaconstantinou J, Perez-Polo JR. Age-associated alterations in hippocampal and basal forebrain nuclear factor kappa B activity. Journal of Neuroscience Research. 48: 580-7. PMID 9210528 DOI: 10.1002/(Sici)1097-4547(19970615)48:6<580::Aid-Jnr11>3.0.Co;2-Z |
0.375 |
|
| 1997 |
Saito H, Papaconstantinou J, Sato H, Goldstein S. Regulation of a novel gene encoding a lysyl oxidase-related protein in cellular adhesion and senescence Journal of Biological Chemistry. 272: 8157-8160. PMID 9079631 DOI: 10.1074/Jbc.272.13.8157 |
0.362 |
|
| 1996 |
Broughan TA, Jin GF, Papaconstantinou J. Early gene response to hepatic ischemia/reperfusion Journal of Surgical Research. 63: 98-104. PMID 8661180 DOI: 10.1006/Jsre.1996.0230 |
0.338 |
|
| 1996 |
Gilpin DA, Hsieh CC, Kuninger DT, Herndon DN, Papaconstantinou J. Effect of thermal injury on the expression of transcription factors that regulate acute phase response genes: the response of C/EBP alpha, C/EBP beta, and C/EBP delta to thermal injury. Surgery. 119: 674-83. PMID 8650608 DOI: 10.1016/S0039-6060(96)80192-9 |
0.748 |
|
| 1996 |
Gilpin DA, Hsieh CC, Kuninger DT, Herndon DN, Papaconstantinou J. Regulation of the acute phase response genes alpha 1-acid glycoprotein and alpha 1-antitrypsin correlates with sensitivity to thermal injury. Surgery. 119: 664-73. PMID 8650607 DOI: 10.1016/S0039-6060(96)80191-7 |
0.725 |
|
| 1996 |
An MR, Hsieh CC, Reisner PD, Rabek JP, Scott SG, Kuninger DT, Papaconstantinou J. Evidence for posttranscriptional regulation of C/EBPalpha and C/EBPbeta isoform expression during the lipopolysaccharide-mediated acute-phase response. Molecular and Cellular Biology. 16: 2295-306. PMID 8628296 DOI: 10.1128/Mcb.16.5.2295 |
0.738 |
|
| 1996 |
Rabek J, Soott S, Hsieh CC, Reisner P, Papaconstantinou J. Induction of C/EBPO gene expression in mouse liver Faseb Journal. 10. |
0.341 |
|
| 1995 |
Ghebranious N, Knoll BJ, Yavorkovsky L, Ilic Z, Papaconstantinou J, Lozano G, Sell S. Developmental control of transcription of the cat reporter gene by a truncated mouse alphafetoprotein gene regulatory region in transgenic mice Molecular Reproduction and Development. 42: 1-6. PMID 8562043 DOI: 10.1002/Mrd.1080420102 |
0.405 |
|
| 1995 |
Grompe M, Lindstedt S, Al-Dhalimy M, Kennaway NG, Papaconstantinou J, Torres-Ramos CA, Ou CN, Finegold M. Pharmacological correction of neonatal lethal hepatic dysfunction in a murine model of hereditary tyrosinaemia type I Nature Genetics. 10: 453-460. PMID 7545495 DOI: 10.1038/Ng0895-453 |
0.334 |
|
| 1994 |
PAPACONSTANTINOU J. Unifying Model of the Programmed (Intrinsic) and Stochastic (Extrinsic) Theories of Aging: The Stress Response Genes, Signal Transduction‐Redox Pathways and Aging Annals of the New York Academy of Sciences. 719: 195-211. PMID 8010593 DOI: 10.1111/J.1749-6632.1994.Tb56829.X |
0.335 |
|
| 1994 |
Rabek JP, Zhang DE, Torres-Ramos CA, Papaconstantinou J. Analysis of the mechanism of glucocorticoid-mediated down regulation of the mouse α-fetoprotein gene Bba - Gene Structure and Expression. 1218: 136-144. PMID 7517187 DOI: 10.1016/0167-4781(94)90002-7 |
0.395 |
|
| 1993 |
Menguito CA, Keherly MJ, Tang C, Papaconstantinou J, Weigel PH. Molecular cloning, sequence, structural analysis and expression of the histidyl-tRNA synthetase gene from Streptococcus equisimilis. Nucleic Acids Research. 21: 615-20. PMID 8441673 DOI: 10.1093/Nar/21.3.615 |
0.322 |
|
| 1993 |
Yiangou M, Papaconstantinou J. The differential induction of α1-acid glycoprotein and serum amyloid A genes by heavy metals Bba - Gene Structure and Expression. 1174: 123-132. PMID 8357829 DOI: 10.1016/0167-4781(93)90106-N |
0.348 |
|
| 1993 |
Menguito CA, Papaconstantinou J, Weigel PH. The histidyl-tRNA synthetase from Streptococcus equisimilis: overexpression in Escherichia coli, purification, and characterization. Preparative Biochemistry. 23: 449-72. PMID 8248028 DOI: 10.1080/10826069308544569 |
0.315 |
|
| 1992 |
Alam T, An MR, Papaconstantinou J. Differential expression of three C/EBP isoforms in multiple tissues during the acute phase response Journal of Biological Chemistry. 267: 5021-5024. PMID 1371993 |
0.326 |
|
| 1992 |
Alam T, Papaconstantinou J. Interaction of acute-phase-inducible and liver-enriched nuclear factors with the promoter region of the mouse α1-acid glycoprotein gene-1 Biochemistry. 31: 1928-1936. PMID 1371400 DOI: 10.1021/Bi00122A005 |
0.4 |
|
| 1991 |
Carter KC, Post DJ, Papaconstantinou J. Differential expression of the mouse α1-acid glycoprotein genes (AGP-1 and AGP-2) during inflammation and aging Bba - Gene Structure and Expression. 1089: 197-205. PMID 2054382 DOI: 10.1016/0167-4781(91)90008-A |
0.331 |
|
| 1986 |
Widen SG, Papaconstantinou J. Liver-specific expression of the mouse α-fetoprotein gene is mediated by cis-acting DNA elements Proceedings of the National Academy of Sciences of the United States of America. 83: 8196-8200. PMID 2430280 DOI: 10.1073/Pnas.83.21.8196 |
0.358 |
|
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