Erik L. Hewlett - Publications

Affiliations: 
University of Virginia, Charlottesville, VA 
Area:
Microbiology Biology, Pharmacology

164 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Boehm DT, Hall JM, Wong TY, DiVenere A, Sen-Kilic E, Bevere JR, Bradford SD, Blackwood CB, Elkins C, DeRoos KA, Gray MC, Cooper CG, Varney ME, Maynard JA, Hewlett EL, et al. Evaluation of adenylate cyclase toxoid antigen in acellular pertussis vaccines using a challenge model in mice. Infection and Immunity. PMID 30012638 DOI: 10.1128/IAI.00857-17  0.64
2017 Gonyar LA, Gray MC, Christianson GJ, Mehrad B, Hewlett EL. Albumin, in the presence of calcium, elicits a massive increase in extracellular Bordetella adenylate cyclase toxin. Infection and Immunity. PMID 28396321 DOI: 10.1128/IAI.00198-17  0.64
2017 Wang X, Stapleton JA, Klesmith JR, Hewlett EL, Whitehead TA, Maynard JA. Fine epitope mapping of two antibodies neutralizing the Bordetella adenylate cyclase toxin. Biochemistry. PMID 28177609 DOI: 10.1021/acs.biochem.6b01163  0.32
2016 Eby JC, Gray MC, Warfel JM, Merkel TJ, Hewlett EL. Use of a toxin neutralization assay to characterize the serologic response to adenylate cyclase toxin after infection with Bordetella pertussis. Clinical and Vaccine Immunology : Cvi. PMID 27760780 DOI: 10.1128/CVI.00370-16  0.64
2015 Wang X, Gray MC, Hewlett EL, Maynard JA. The Bordetella adenylate cyclase repeat-in-toxin (RTX) domain is immunodominant and elicits neutralizing antibodies. The Journal of Biological Chemistry. 290: 23025. PMID 26386047 DOI: 10.1074/jbc.A114.585281  0.64
2015 D'Auria KM, Bloom MJ, Reyes Y, Gray MC, van Opstal EJ, Papin JA, Hewlett EL. High temporal resolution of glucosyltransferase dependent and independent effects of Clostridium difficile toxins across multiple cell types. Bmc Microbiology. 15: 7. PMID 25648517 DOI: 10.1186/s12866-015-0361-4  0.64
2014 Eby JC, Gray MC, Hewlett EL. Cyclic AMP-mediated suppression of neutrophil extracellular trap formation and apoptosis by the Bordetella pertussis adenylate cyclase toxin. Infection and Immunity. 82: 5256-69. PMID 25287922 DOI: 10.1128/IAI.02487-14  0.64
2014 Hewlett EL, Burns DL, Cotter PA, Harvill ET, Merkel TJ, Quinn CP, Stibitz ES. Pertussis pathogenesis--what we know and what we don't know. The Journal of Infectious Diseases. 209: 982-5. PMID 24626533 DOI: 10.1093/infdis/jit639  0.64
2013 Masin J, Fiser R, Linhartova I, Osicka R, Bumba L, Hewlett EL, Benz R, Sebo P. Differences in purinergic amplification of osmotic cell lysis by the pore-forming RTX toxins Bordetella pertussis CyaA and Actinobacillus pleuropneumoniae ApxIA: the role of pore size. Infection and Immunity. 81: 4571-82. PMID 24082076 DOI: 10.1128/IAI.00711-13  0.64
2013 D'Auria KM, Kolling GL, Donato GM, Warren CA, Gray MC, Hewlett EL, Papin JA. In vivo physiological and transcriptional profiling reveals host responses to Clostridium difficile toxin A and toxin B. Infection and Immunity. 81: 3814-24. PMID 23897615 DOI: 10.1128/IAI.00869-13  0.64
2013 Eby JC, Gray MC, Warfel JM, Paddock CD, Jones TF, Day SR, Bowden J, Poulter MD, Donato GM, Merkel TJ, Hewlett EL. Quantification of the adenylate cyclase toxin of Bordetella pertussis in vitro and during respiratory infection. Infection and Immunity. 81: 1390-8. PMID 23429530 DOI: 10.1128/IAI.00110-13  0.64
2012 Henderson MW, Inatsuka CS, Sheets AJ, Williams CL, Benaron DJ, Donato GM, Gray MC, Hewlett EL, Cotter PA. Contribution of Bordetella filamentous hemagglutinin and adenylate cyclase toxin to suppression and evasion of interleukin-17-mediated inflammation. Infection and Immunity. 80: 2061-75. PMID 22473603 DOI: 10.1128/IAI.00148-12  0.64
2012 Chavali AK, D'Auria KM, Hewlett EL, Pearson RD, Papin JA. A metabolic network approach for the identification and prioritization of antimicrobial drug targets. Trends in Microbiology. 20: 113-23. PMID 22300758 DOI: 10.1016/j.tim.2011.12.004  0.64
2012 Donato GM, Goldsmith CS, Paddock CD, Eby JC, Gray MC, Hewlett EL. Delivery of Bordetella pertussis adenylate cyclase toxin to target cells via outer membrane vesicles. Febs Letters. 586: 459-65. PMID 22289177 DOI: 10.1016/j.febslet.2012.01.032  0.64
2012 D'Auria KM, Donato GM, Gray MC, Kolling GL, Warren CA, Cave LM, Solga MD, Lannigan JA, Papin JA, Hewlett EL. Systems analysis of the transcriptional response of human ileocecal epithelial cells to Clostridium difficile toxins and effects on cell cycle control. Bmc Systems Biology. 6: 2. PMID 22225989 DOI: 10.1186/1752-0509-6-2  0.64
2012 Eby JC, Gray MC, Mangan AR, Donato GM, Hewlett EL. Role of CD11b/CD18 in the process of intoxication by the adenylate cyclase toxin of Bordetella pertussis. Infection and Immunity. 80: 850-9. PMID 22144488 DOI: 10.1128/IAI.05979-11  0.64
2011 Gray MC, Hewlett EL. Cell cycle arrest induced by the bacterial adenylate cyclase toxins from Bacillus anthracis and Bordetella pertussis. Cellular Microbiology. 13: 123-34. PMID 20946259 DOI: 10.1111/j.1462-5822.2010.01525.x  0.64
2011 Hewlett EL. Whooping Cough and Other Bordetella Infections Goldman's Cecil Medicine: Twenty Fourth Edition. 2: 1900-1903. DOI: 10.1016/B978-1-4377-1604-7.00321-3  0.64
2010 Eby JC, Ciesla WP, Hamman W, Donato GM, Pickles RJ, Hewlett EL, Lencer WI. Selective translocation of the Bordetella pertussis adenylate cyclase toxin across the basolateral membranes of polarized epithelial cells. The Journal of Biological Chemistry. 285: 10662-70. PMID 20139088 DOI: 10.1074/jbc.M109.089219  0.64
2009 Tondella ML, Carlone GM, Messonnier N, Quinn CP, Meade BD, Burns DL, Cherry JD, Guiso N, Hewlett EL, Edwards KM, Xing D, Giammanco A, Wirsing von König CH, Han L, Hueston L, et al. International Bordetella pertussis assay standardization and harmonization meeting report. Centers for Disease Control and Prevention, Atlanta, Georgia, United States, 19-20 July 2007. Vaccine. 27: 803-14. PMID 19071179 DOI: 10.1016/j.vaccine.2008.11.072  0.64
2007 Perkins DJ, Gray MC, Hewlett EL, Vogel SN. Bordetella pertussis adenylate cyclase toxin (ACT) induces cyclooxygenase-2 (COX-2) in murine macrophages and is facilitated by ACT interaction with CD11b/CD18 (Mac-1). Molecular Microbiology. 66: 1003-15. PMID 17927697 DOI: 10.1111/j.1365-2958.2007.05972.x  0.64
2006 Easley CJ, Karlinsey JM, Bienvenue JM, Legendre LA, Roper MG, Feldman SH, Hughes MA, Hewlett EL, Merkel TJ, Ferrance JP, Landers JP. A fully integrated microfluidic genetic analysis system with sample-in-answer-out capability. Proceedings of the National Academy of Sciences of the United States of America. 103: 19272-7. PMID 17159153 DOI: 10.1073/pnas.0604663103  0.64
2006 Mehlmann LM, Kalinowski RR, Ross LF, Parlow AF, Hewlett EL, Jaffe LA. Meiotic resumption in response to luteinizing hormone is independent of a Gi family G protein or calcium in the mouse oocyte. Developmental Biology. 299: 345-55. PMID 16949564 DOI: 10.1016/j.ydbio.2006.07.039  0.64
2006 Hewlett EL, Donato GM, Gray MC. Macrophage cytotoxicity produced by adenylate cyclase toxin from Bordetella pertussis: more than just making cyclic AMP! Molecular Microbiology. 59: 447-59. PMID 16390441 DOI: 10.1111/j.1365-2958.2005.04958.x  0.64
2005 Donato GM, Hsia HL, Green CS, Hewlett EL. Adenylate cyclase toxin (ACT) from Bordetella hinzii: characterization and differences from ACT of Bordetella pertussis. Journal of Bacteriology. 187: 7579-88. PMID 16267282 DOI: 10.1128/JB.187.22.7579-7588.2005  0.64
2005 Lee SJ, Gray MC, Zu K, Hewlett EL. Oligomeric behavior of Bordetella pertussis adenylate cyclase toxin in solution. Archives of Biochemistry and Biophysics. 438: 80-7. PMID 15878155 DOI: 10.1016/j.abb.2005.04.001  0.64
2005 Hewlett EL, Edwards KM. Clinical practice. Pertussis--not just for kids. The New England Journal of Medicine. 352: 1215-22. PMID 15788498 DOI: 10.1056/NEJMcp041025  0.64
2004 Gray MC, Donato GM, Jones FR, Kim T, Hewlett EL. Newly secreted adenylate cyclase toxin is responsible for intoxication of target cells by Bordetella pertussis. Molecular Microbiology. 53: 1709-19. PMID 15341649 DOI: 10.1111/j.1365-2958.2004.04227.x  0.64
2002 Zaretzky FR, Gray MC, Hewlett EL. Mechanism of association of adenylate cyclase toxin with the surface of Bordetella pertussis: a role for toxin-filamentous haemagglutinin interaction. Molecular Microbiology. 45: 1589-98. PMID 12354227 DOI: 10.1046/j.1365-2958.2002.03107.x  0.64
2002 Gao Z, Young RA, Trucco MM, Greene SR, Hewlett EL, Matschinsky FM, Wolf BA. Protein kinase A translocation and insulin secretion in pancreatic beta-cells: studies with adenylate cyclase toxin from Bordetella pertussis. The Biochemical Journal. 368: 397-404. PMID 12180908 DOI: 10.1042/BJ20020999  0.64
2001 Rhodes CR, Gray MC, Watson JM, Muratore TL, Kim SB, Hewlett EL, Grisham CM. Structural consequences of divalent metal binding by the adenylyl cyclase toxin of Bordetella pertussis. Archives of Biochemistry and Biophysics. 395: 169-76. PMID 11697853 DOI: 10.1006/abbi.2001.2553  0.64
2001 Gray MC, Lee SJ, Gray LS, Zaretzky FR, Otero AS, Szabo G, Hewlett EL. Translocation-specific conformation of adenylate cyclase toxin from Bordetella pertussis inhibits toxin-mediated hemolysis. Journal of Bacteriology. 183: 5904-10. PMID 11566989 DOI: 10.1128/JB.183.20.5904-5910.2001  0.64
2000 Hewlett EL, Kim KJ, Lee SJ, Gray MC. Adenylate cyclase toxin from Bordetella pertussis: current concepts and problems in the study of toxin functions. International Journal of Medical Microbiology : Ijmm. 290: 333-5. PMID 11111907 DOI: 10.1016/S1438-4221(00)80035-1  0.64
2000 Weingart CL, Mobberley-Schuman PS, Hewlett EL, Gray MC, Weiss AA. Neutralizing antibodies to adenylate cyclase toxin promote phagocytosis of Bordetella pertussis by human neutrophils Infection and Immunity. 68: 7152-7155. PMID 11083845 DOI: 10.1128/IAI.68.12.7152-7155.2000  0.64
2000 Lim KB, Walker CR, Guo L, Pellett S, Shabanowitz J, Hunt DF, Hewlett EL, Ludwig A, Goebel W, Welch RA, Hackett M. Escherichia coli alpha-hemolysin (HlyA) is heterogeneously acylated in vivo with 14-, 15-, and 17-carbon fatty acids. The Journal of Biological Chemistry. 275: 36698-702. PMID 10978310 DOI: 10.1074/jbc.C000544200  0.64
1999 Gray MC, Ross W, Kim K, Hewlett EL. Characterization of binding of adenylate cyclase toxin to target cells by flow cytometry Infection and Immunity. 67: 4393-4399. PMID 10456879  0.64
1999 Hewlett EL. A commentary on the pathogenesis of pertussis Clinical Infectious Diseases. 28. PMID 10447025  0.64
1999 Lee SJ, Gray MC, Guo L, Sebo P, Hewlett EL. Epitope mapping of monoclonal antibodies against Bordetella pertussis adenylate cyclase toxin. Infection and Immunity. 67: 2090-5. PMID 10225859  0.64
1998 Hewlett EL, Halperin SA. Serological correlates of immunity to Bordetella pertussis: Editorial Vaccine. 16: 1899-1900. PMID 9796040 DOI: 10.1016/S0264-410X(98)00228-X  0.64
1998 Rhodes CH, Hewlett EL, Grisham CM. Metal binding studies of adenylyl cyclase toxin Faseb Journal. 12: A1470.  0.64
1997 Hewlett EL. Preparation and composition of acellular pertussis vaccines. Consideration of potential effects on vaccine efficacy Developments in Biological Standardization. 89: 143-151. PMID 9272344  0.64
1997 Hewlett EL. Pertussis: Current concepts of pathogenesis and prevention Pediatric Infectious Disease Journal. 16. PMID 9109161 DOI: 10.1097/00006454-199704001-00002  0.64
1997 Brito GAC, Souza MHLP, Melo-Filho AA, Hewlett EL, Lima AAM, Flores CA, Ribeiro RA. Role of pertussis toxin A subunit in neutrophil migration and vascular permeability Infection and Immunity. 65: 1114-1118. PMID 9038326  0.64
1996 Pelleg A, Hurt CM, Hewlett EL. ATP shortens atrial action potential duration in the dog: role of adenosine, the vagus nerve, and G protein. Canadian Journal of Physiology and Pharmacology. 74: 15-22. PMID 8963948 DOI: 10.1139/cjpp-74-1-15  0.64
1996 Login IS, Hewlett EL. Adenylate cyclase in striatal cholinergic interneurons regulates acetylcholine release Brain Research. 735: 330-334. PMID 8911674 DOI: 10.1016/0006-8993(96)00890-6  0.64
1996 Hewlett EL. Acellular pertussis trial [5] Pediatrics. 98: 800. PMID 8885972  0.64
1995 Otero AS, Yi XB, Gray MC, Szabo G, Hewlett EL. Membrane depolarization prevents cell invasion by Bordetella pertussis adenylate cyclase toxin Journal of Biological Chemistry. 270: 9695-9697. PMID 7730345 DOI: 10.1074/jbc.270.17.9695  0.64
1995 Hackett M, Walker CB, Guo L, Gray MC, Van Cuyk S, Ullmann A, Shabanowitz J, Hunt DF, Hewlett EL, Sebo P. Hemolytic, but not cell-invasive activity, of adenylate cyclase toxin is selectively affected by differential fatty-acylation in Escherichia coli. The Journal of Biological Chemistry. 270: 20250-3. PMID 7657593 DOI: 10.1074/jbc.270.35.20250  0.64
1995 Thomazzi SM, Souza MHLP, Melo-Filho AA, Hewlett EL, Lima AAM, Ribeiro RA. Pertussis toxin from Bordetella pertussis blocks neutrophil migration and neutrophil-dependent edema in response to inflammation Brazilian Journal of Medical and Biological Research. 28: 120-124. PMID 7581020  0.64
1994 Szabo G, Gray MC, Hewlett EL. Adenylate cyclase toxin from Bordetella pertussis produces ion conductance across artificial lipid bilayers in a calcium- and polarity-dependent manner Journal of Biological Chemistry. 269: 22496-22499. PMID 8077197  0.64
1994 Sindt KA, Hewlett EL, Redpath GT, Rappuoli R, Gray LS, Vandenberg SR. Pertussis toxin activates platelets through an interaction with platelet glycoprotein Ib. Infection and Immunity. 62: 3108-14. PMID 8039878  0.64
1994 Hackett M, Guo L, Shabanowitz J, Hunt DF, Hewlett EL. Internal lysine palmitoylation in adenylate cyclase toxin from Bordetella pertussis Science. 266: 433-435. PMID 7939682  0.64
1994 Murayama T, Hewlett EL, Maloney NJ, Justice JM, Moss J. Effect of temperature and host factors on the activities of pertussis toxin and Bordetella adenylate cyclase Biochemistry. 33: 15293-15297. PMID 7803392  0.64
1993 Arciniega JL, Hewlett EL, Edwards KM, Burns DL. Antibodies to Bordetella pertussis adenylate cyclase toxin in neonatal and maternal sera Fems Immunology and Medical Microbiology. 6: 325-330. PMID 8499896  0.64
1993 Hewlett EL, Gray MC, Ehrmann IE, Maloney NJ, Otero AS, Gray L, Allietta M, Szabo G, Weiss AA, Barry EM. Characterization of adenylate cyclase toxin from a mutant of Bordetella pertussis defective in the activator gene, cyaC Journal of Biological Chemistry. 268: 7842-7848. PMID 8385122  0.64
1992 Hewlett EL. Pertussis in adults: Significance for disease transmission and immunisation policy Journal of Medical Microbiology. 36: 141-142. PMID 1548687  0.64
1992 Ehrmann IE, Weiss AA, Goodwin MS, Gray MC, Barry E, Hewlett EL. Enzymatic activity of adenylate cyclase toxin from Bordetella pertussis is not required for hemolysis Febs Letters. 304: 51-56. PMID 1319923 DOI: 10.1016/0014-5793(92)80587-7  0.64
1991 Ehrmann IE, Gray MC, Gordon VM, Gray LS, Hewlett EL. Hemolytic activity of adenylate cyclase toxin from Bordetella pertussis Febs Letters. 278: 79-83. PMID 1993477 DOI: 10.1016/0014-5793(91)80088-K  0.64
1991 Barry EM, Weiss AA, Ehrmann IE, Gray MC, Hewlett EL, Goodwin MSM. Bordetella pertussis adenylate cyclase toxin and hemolytic activities require a second gene, cyaC, for activation Journal of Bacteriology. 173: 720-726. PMID 1987161  0.64
1991 Arciniega JL, Hewlett EL, Johnson FD, Deforest A, Wassilak SGF, Onorato IM, Manclark CR, Burns DL. Human serologic response to envelope-associated proteins and adenylate cyclase toxin of Bordetella pertussis Journal of Infectious Diseases. 163: 135-142. PMID 1984460  0.64
1991 Hewlett EL, Gray L, Allietta M, Ehrmann I, Gordon VM, Gray MC. Adenylate cyclase toxin from Bordetella pertussis: Conformational change associated with toxin activity Journal of Biological Chemistry. 266: 17503-17508. PMID 1894634  0.64
1991 Roberts M, Fairweather NF, Leininger E, Pickard D, Hewlett EL, Robinson A, Hayward C, Dougan G, Charles LG. Construction and characterization of Bordetella pertussis mutants lacking the vir‐regulated P.69 outer membrane protein Molecular Microbiology. 5: 1393-1404. PMID 1787793 DOI: 10.1111/j.1365-2958.1991.tb00786.x  0.64
1990 Gutierrez GE, Mundy GR, Manning DR, Hewlett EL, Katz MS. Transforming growth factor β enhances parathyroid hormone stimulation of adenylate cyclase in clonal osteoblast-like cells Journal of Cellular Physiology. 144: 438-447. PMID 2391378  0.64
1990 Sullivan GW, Linden J, Hewlett EL, Carper HT, Hylton JB, Mandell GL. Adenosine and related compounds counteract tumor necrosis factor-alpha inhibition of neutrophil migration: implication of a novel cyclic AMP-independent action on the cell surface. Journal of Immunology (Baltimore, Md. : 1950). 145: 1537-44. PMID 2166764  0.64
1990 Weikel CS, Spann CL, Chambers CP, Crane JK, Linden J, Hewlett EL. Phorbol esters enhance the cyclic GMP response of T84 cells to the heat-stable enterotoxin of Escherichia coli (STa) Infection and Immunity. 58: 1402-1407. PMID 1969850  0.64
1990 Cherry JD, Hewlett EL, Mortimer EA. Protective antibodies in pertussis (I) Journal of Pediatrics. 117: 347. DOI: 10.1016/S0022-3476(05)80580-3  0.64
1989 Crane JK, Hewlett EL, Weikel CS. Failure of pertussis toxin to inhibit activation of guanylate cyclase by the heat-stable enterotoxin of Escherichia coli (STa) in the T84 cell line Infection and Immunity. 57: 1186-1191. PMID 2564375  0.64
1989 Hewlett EL, Gordon VM, McCaffery JD, Sutherland WM, Gray MC. Adenylate cyclase toxin from Bordetella pertussis. Identification and purification of the holotoxin molecule Journal of Biological Chemistry. 264: 19379-19384. PMID 2553737  0.64
1989 Wirsing von Koenig CH, Tacken A, Hewlett EL. Detection of Bordetella pertussis by determination of adenylate cyclase activity European Journal of Clinical Microbiology &Amp; Infectious Diseases. 8: 633-636. PMID 2550232 DOI: 10.1007/BF01968146  0.64
1989 Hewlett EL, Cowell JL. Evaluation of the mouse model for study of encephalopathy in pertussis vaccine recipients Infection and Immunity. 57: 661-663. PMID 2537253  0.64
1989 Gray LS, Huber KS, Gray MC, Hewlett EL, Engelhard VH. Pertussis toxin effects on T lymphocytes are mediated through CD3 and not by pertussis toxin catalyzed modification of a G protein Journal of Immunology. 142: 1631-1638. PMID 2521885  0.64
1989 Gordon VM, Young WW, Lechler SM, Gray MC, Leppla SH, Hewlett EL. Adenylate cyclase toxins from Bacillus anthracis and Bordetella pertussis. Different processes for interaction with and entry into target cells. The Journal of Biological Chemistry. 264: 14792-6. PMID 2504710  0.64
1989 Hewlett EL. Current problems in whooping-cough Revista Latinoamericana De Microbiologia. 31: 199-203.  0.64
1988 Luttrell LM, Hewlett EL, Romero G, Rogol AD. Pertussis toxin treatment attenuates some effects of insulin in BC3H-1 murine myocytes Journal of Biological Chemistry. 263: 6134-6141. PMID 3283121  0.64
1988 Joshi LR, Boland SR, Hewlett EL, Katz MS. Inhibition of adenylate cyclase from luteinized rat ovary by monovalent cations: Roles of the stimulatory guanine nucleotide-binding regulatory component and stimulatory hormone receptor Archives of Biochemistry and Biophysics. 261: 134-147. PMID 3124764 DOI: 10.1016/0003-9861(88)90112-9  0.64
1988 Hewlett EL. Pertussis in adults: Possible use of booster doses for control Tokai Journal of Experimental and Clinical Medicine. 13: 125-128. PMID 3078801  0.64
1988 Brennan MJ, Li ZM, Shahin RD, Burns DL, Nguyen NY, Liu TY, Gray MC, Hewlett EL, Manclark CR. Structural and functional properties of a 69-kilodalton outer membrane protein of Bordetella pertussis Tokai Journal of Experimental and Clinical Medicine. 13: 211-215. PMID 2908522  0.64
1988 McLafferty MA, Harcus DR, Hewlett EL. Nucleotide sequence and characterization of a repetitive DNA element from the genome of Bordetella pertussis with characteristics of an insertion sequence Journal of General Microbiology. 134: 2297-2306. PMID 2908119  0.64
1988 Gordon VM, Leppla SH, Hewlett EL. Inhibitors of receptor-mediated endocytosis block the entry of Bacillus anthracis adenylate cyclase toxin but not that of Bordetella pertussis adenylate cyclase toxin. Infection and Immunity. 56: 1066-9. PMID 2895741  0.64
1988 Galgiani JN, Hewlett EL, Friedman RL. Effects of adenylate cyclase toxin from Bordetella pertussis on human neutrophil interactions with Coccidioides immitis and Staphylococcus aureus. Infection and Immunity. 56: 751-5. PMID 2894360  0.64
1988 Veldhuis JD, Rodgers RJ, Hewlett EL, Azimi P, Garmey J, Gray M, Juchter D, Wait A. Actions of cyclic adenosine monophosphate on the cytodifferentiation of ovarian cells: Studies in cultured swine granulosa cells using a novel exogenous adenylate cyclase from Bordetella pertussis Molecular Endocrinology. 2: 499-506. PMID 2843759  0.64
1988 Moss J, Hom BE, Hewlett EL, Tsai SC, Adamik R, Halpern JL, Russ Price S, Manganiello VC. Mechanism of enhanced sensitivity to bradykinin in pertussis toxin-treated fibroblasts: Toxin increases bradykinin-stimulated prostaglandin formation Molecular Pharmacology. 34: 279-285. PMID 2843748  0.64
1988 Gray LS, Gnarra J, Hewlett EL, Engelhard VH. Increased intracellular cyclic adenosine monophosphate inhibits T lymphocyte-mediated cytolysis by two distinct mechanisms Journal of Experimental Medicine. 167: 1963-1968. PMID 2838563  0.64
1987 Roop RM, Veit HP, Sinsky RJ, Hewlett EL, Kornegay ET. Virulence factors of Bordetella bronchiseptica associated with the production of infectious atropine rhinitis and pneumonia in experimentally infected neonatal swine Infection and Immunity. 55: 217-222. PMID 3793231  0.64
1987 Pearson RD, Hewlett EL. Use of pyrimethamine-sulfadoxine (Fansidar) in prophylaxis against chloroquine-resistant plasmodium falciparum and Pneumocystis carinii Annals of Internal Medicine. 106: 714-718. PMID 3551713  0.64
1987 Gutierrez GE, Mundy GR, Derynck R, Hewlett EL, Katz MS. Inhibition of parathyroid hormone-responsive adenylate cyclase in clonal osteoblast-like cells by transforming growth factor alpha and epidermal growth factor. The Journal of Biological Chemistry. 262: 15845-50. PMID 3500168  0.64
1987 Malchoff CD, Huang L, Gillespie N, Palasi CV, Schwartz CF, Cheng K, Hewlett EL, Larner J. A putative mediator of insulin action which inhibits adenylate cyclase and adenosine 3',5'-monophosphate-dependent protein kinase: Partial purification from rat liver: Site and kinetic mechanism of action Endocrinology. 120: 1327-1337. PMID 3030696  0.64
1987 Pearson RD, Symes P, Conboy M, Weiss AA, Hewlett EL. Inhibition of monocyte oxidative responses by Bordetella pertussis adenylate cyclase toxin Journal of Immunology. 139: 2749-2754. PMID 2888823  0.64
1986 Musser JM, Hewlett EL, Peppler MS, Selander RK. Genetic diversity and relationships in populations of Bordetella spp. Journal of Bacteriology. 166: 230-7. PMID 3957867  0.64
1986 Zysk JR, Pobiner BF, Hewlett EL, Garrison JC, Cronin MJ. Pertussis toxin mediates adp-ribosylation of pituitary membrane proteins Endocrine Research. 12: 157-170. PMID 3732193 DOI: 10.1080/07435808609035435  0.64
1986 Johnson RM, Connelly PA, Sisk RB, Pobiner BF, Hewlett EL, Garrison JC. Pertussis toxin or phorbol 12-myristate 13-acetate can distinguish between epidermal growth factor- and angiotensin-stimulated signals in hepatocytes Proceedings of the National Academy of Sciences of the United States of America. 83: 2032-2036. PMID 3083411  0.64
1986 Hinkle PM, Hewlett EL, Gershengorn MC. Thyroliberin action in pituitary cells is not inhibited by pertussis toxin Biochemical Journal. 237: 181-186. PMID 3026309  0.64
1986 Cronin MJ, Evans WS, Rogol AD, Weiss AA, Thorner MO, Orth DN, Nicholson WE, Yasumoto T, Hewlett EL. Prokaryotic adenylate cyclase toxin stimulates anterior pituitary cells in culture American Journal of Physiology - Endocrinology and Metabolism. 251. PMID 3017120  0.64
1986 Weiss AA, Hewlett EL. Virulence factors of Bordetella pertussis Annual Review of Microbiology. 40: 661-686. PMID 2877614  0.64
1986 Cronin MJ, Summers ST, Sortino MA, Hewlett EL. Protein kinase C enhances growth hormone releasing factor (1-40)-stimulated cyclic AMP levels in anterior pituitary. Actions of somatostatin and pertussis toxin Journal of Biological Chemistry. 261: 13932-13935. PMID 2876983  0.64
1986 Weiss J, Hewlett EL, Cronin MJ. Bacterial adenylate cyclase increases cyclic AMP and hormone release in pituitary tumor cells Biochemical and Biophysical Research Communications. 136: 463-469. PMID 2871835 DOI: 10.1016/0006-291X(86)90463-8  0.64
1985 Hewlett EL, Pearson RD, Zilberstein D, Dwyer DM. Antiprotozoal activity of tricyclic compounds Science. 230: 1063-1064. PMID 4059923  0.64
1985 Pearson RD, Hewlett EL. Niclosamide therapy for tapeworm infections Annals of Internal Medicine. 102: 550-551. PMID 3977200  0.64
1985 Hsia JA, Tsai SC, Adamik R, Yost DA, Hewlett EL, Moss J. Amino acid-specific ADP-ribosylation. Sensitivity to hydroxylamine of [cysteine(ADP-ribose)]protein and [arginine(ADP-ribose)]protein linkages Journal of Biological Chemistry. 260: 16187-16191. PMID 3934172  0.64
1985 Judd AM, Koike K, Schettini G, Login IS, Hewlett EL, Yasumoto T, MacLeod RM. Dopamine decreases 7315a tumor cell prolactin release induced by calcium mobilization Endocrinology. 117: 1215-1221. PMID 3926467  0.64
1985 Bruni P, Hewlett EL, Moss J. Effects of pertussis toxin-catalyzed ADP-ribosylation on interactions of transducin and the inhibitory GTP-binding protein of adenylate cyclase with guanyl nucleotides Biochemical and Biophysical Research Communications. 127: 999-1006. PMID 3921021 DOI: 10.1016/S0006-291X(85)80043-7  0.64
1985 Pearson RD, Hewlett EL. Pentamidine for the treatment of Pneumocystis carinii pneumonia and other protozoal diseases Annals of Internal Medicine. 103: 782-786. PMID 3901852  0.64
1985 Hewlett EL. Selective primary health care: Strategies for control of disease in the developing world. xviii pertussis and diphtheria Reviews of Infectious Diseases. 7: 426-433. PMID 3895357 DOI: 10.1093/clinids/7.3.426  0.64
1985 Watkins PA, Burns DL, Kanaho Y, Liu TY, Hewlett EL, Moss J. ADP-ribosylation of transducin by pertussis toxin Journal of Biological Chemistry. 260: 13478-13482. PMID 3863817  0.64
1985 Hewlett EL, McKelway RB, Sapiain LA, Hernandez LA, Myers GA. Depression of delayed hypersensitivity responses in patients with pertussis. Developments in Biological Standardization. 61: 241-7. PMID 3835078  0.64
1985 Pobiner BF, Hewlett EL, Garrison JC. Role of N(i) in coupling angiotensin receptors to inhibition of adenylate cyclase in hepatocytes Journal of Biological Chemistry. 260: 16200-16209. PMID 2999149  0.64
1985 Veldhuis JD, Hewlett EL. Evidence for a functionally active inhibitory guanine nucleotide-binding regulatory protein in the swine ovary Biochemical and Biophysical Research Communications. 131: 1168-1174. PMID 2996539 DOI: 10.1016/0006-291X(85)90213-X  0.64
1985 Evans WS, Brannagan TH, Limber ER, Cronin MJ, Rogol AD, Hewlett EL, Thorner MO. Differential effects of forskolin on LH and GH release The American Journal of Physiology. 249. PMID 2996364  0.64
1985 Bruni P, Burns DL, Hewlett EL, Moss J. Effects of pertussis toxin on cAMP and cGMP responses to carbamylcholine in N1E-115 neuroblastoma cells Molecular Pharmacology. 28: 229-234. PMID 2991740  0.64
1985 Wade BH, Wright GG, Hewlett EL, Leppla SH, Mandell GL. Anthrax Toxin Components Stimulate Chemotaxis of Human Polymorphonuclear Neutrophils Proceedings of the Society For Experimental Biology and Medicine. 179: 159-162. PMID 2986152 DOI: 10.3181/00379727-179-42078  0.64
1985 Hsia JA, Hewlett EL, Moss J. Heterologous densitization of adenylate cyclase with prostaglandin E'1 alters sensitivity to inhibitory as well as stimulatory agonists Journal of Biological Chemistry. 260: 4922-4926. PMID 2985570  0.64
1985 Hewlett EL, Weiss AA, Crane JK, Pearson RD, Anderson HJ, Myers GA, Evans WS, Hantske LL, Kay HD, Cronin MJ. Bordetella extracytoplasmic adenylate cyclase: actions as a bacterial toxin. Developments in Biological Standardization. 61: 21-6. PMID 2872107  0.64
1985 Weiss AA, Hewlett EL, Myers GA, Falkow S. Genetic studies of the molecular basis of whooping cough. Developments in Biological Standardization. 61: 11-9. PMID 2872097  0.64
1985 Ravdin JI, Murphy CF, Salata RA, Guerrant RL, Hewlett EL. N-Acetyl-D-galactosamine-inhibitable adherence lectin of Entamoeba histolytica. I. Partial purification and relation to amoebic virulence in vitro. The Journal of Infectious Diseases. 151: 804-15. PMID 2859338 DOI: 10.1093/infdis/151.5.804  0.64
1985 Watkins PA, Stanley SJ, Hewlett EL. Stimulation of the thiol-dependent ADP-ribosyltransferase and NAD glycohydrolase activities of Bordetella pertussis toxin by adenine nucleotides, phospholipids, and detergents Federation Proceedings. 44.  0.64
1985 Pobiner BF, Hewlett EL, Garrison JC. Pertussis toxin blocks the angiotensin II inhibition of rat liver adenylate cyclase Federation Proceedings. 44.  0.64
1985 Zysk JR, Hewlett EL, Pobiner BF. Adenosine diphosphate-ribosylation (ADP-R) of anterior pituitary membranes by pertussis toxin Federation Proceedings. 44.  0.64
1984 Pearson RD, Manian AA, Hall D, Harcus JL, Hewlett EL. Antileishmanial activity of chlorpromazine Antimicrobial Agents and Chemotherapy. 25: 571-574. PMID 6732225  0.64
1984 Tsai SC, Adamik R, Kanaho Y, Hewlett EL, Moss J. Effects of guanyl nucleotides and rhodopsin on ADP-ribosylation of the inhibitory GTP-binding component of adenylate cyclase by pertussis toxin Journal of Biological Chemistry. 259: 15320-15323. PMID 6439719  0.64
1984 Long-Krug SA, Weikel CS, Tiemens KT, Hewlett EL, Levine MM, Guerrant RL. Does enteropathogenic Escherichia coli produce heat-labile enterotoxin, heat-stable enterotoxins a or b, or cholera toxin A subunits? Infection and Immunity. 46: 612-614. PMID 6389354  0.64
1984 Pearson RD, Hewlett EL, Guerrant RL. Tropical diseases in North America Disease-a-Month. 30: 1-68. PMID 6365491 DOI: 10.1016/0011-5029(84)90011-7  0.64
1984 Wolff J, Cook GH, Goldhammer AR, Londos C, Hewlett EL. Bordetella pertussis: multiple attacks on host cell cyclic AMP regulation. Advances in Cyclic Nucleotide and Protein Phosphorylation Research. 17: 161-172. PMID 6328913  0.64
1984 Hsia JA, Moss J, Hewlett EL, Vaughan M. Requirement for both choleragen and pertussis toxin to obtain maximal activation of adenylate cyclase in cultured cells Biochemical and Biophysical Research Communications. 119: 1068-1074. PMID 6324776 DOI: 10.1016/0006-291X(84)90883-0  0.64
1984 Cronin MJ, Evans WS, Hewlett EL, Thorner MO. LH release is facilitated by agents that alter cyclic AMP-generating system The American Journal of Physiology. 246. PMID 6320661  0.64
1984 Hsia JA, Moss J, Hewlett EL, Vaughan M. ADP-ribosylation of adenylate cyclase by pertussis toxin. Effects on inhibitory agonist binding Journal of Biological Chemistry. 259: 1086-1090. PMID 6319376  0.64
1984 Moss J, Bruni P, Hsia JA, Tsai SC, Watkins PA, Halpern JL, Burns DL, Kanaho Y, Chang PP, Hewlett EL. Pertussis toxin-catalyzed ADP-ribosylation: effects on the coupling of inhibitory receptors to the adenylate cyclase system. Journal of Receptor Research. 4: 459-74. PMID 6151992 DOI: 10.3109/10799898409042567  0.64
1984 Schettini G, Cronin MJ, Hewlett EL, Thorner MO, MacLeod RM. Human pancreatic tumor growth hormone-releasing factor stimulates anterior pituitary adenylate cyclase activity, adenosine 3',5'-monophosphate accumulation, and growth hormone release in a calmodulin-dependent manner Endocrinology. 115: 1308-1314. PMID 6148231  0.64
1984 Hewlett EL, Cronin MJ, Moss J, Anderson H, Myers GA, Pearson RD. Pertussis toxin: lessons from biological and biochemical effects in different cells. Advances in Cyclic Nucleotide and Protein Phosphorylation Research. 17: 173-82. PMID 6145319  0.64
1984 Watkins PA, Moss J, Burns DL, Hewlett EL, Vaughan M. Inhibition of bovine rod outer segment GTPase by Bordetella pertussis toxin Journal of Biological Chemistry. 259: 1378-1381. PMID 6141165  0.64
1984 Tuomanen EI, Zapiain LA, Galvan P, Hewlett EL. Characterization of antibody inhibiting adherence of Bordetella pertussis to human respiratory epithelial cells Journal of Clinical Microbiology. 20: 167-170. PMID 6092416  0.64
1984 Weiss AA, Hewlett EL, Myers GA, Falkow S. Pertussis toxin and extracytoplasmic adenylate cyclase as virulence factors of Bordetella pertussis. The Journal of Infectious Diseases. 150: 219-22. PMID 6088647  0.64
1984 Adashi EY, Resnick CE, Cronin MJ, Hewlett EL. 'Antigonadal' activity of the neurohypophysial hormones in cultured rat testicular cells: Abolition by pertussis toxin Endocrinology. 115: 839-841. PMID 6086280  0.64
1984 Bruni P, Hewlett EL, Moss J. Effect of pertussis toxin on the interaction of the adenylate cyclase system with Gpp(NH)p Federation Proceedings. 43.  0.64
1984 Hewlett EL, Watkins PA, Burns DL, Moss J. ADP-Ribosylation of transducin subunits by pertussis toxin Federation Proceedings. 43.  0.64
1983 Hewlett EL, Myers GA, Pearson RD. Susceptibility of Bordetella species to growth inhibition and killing by chlorpromazine. Antimicrobial Agents and Chemotherapy. 23: 201-6. PMID 6838185  0.64
1983 Hill DR, Guerrant RL, Pearson RD, Hewlett EL. Giardia lamblia infection of suckling mice Journal of Infectious Diseases. 147: 217-221. PMID 6827138  0.64
1983 Hewlett EL, Sauer KT, Myers GA, Cowell JL, Guerrant RL. Induction of a novel morphological response in Chinese hamster ovary cells by pertussis toxin. Infection and Immunity. 40: 1198-203. PMID 6682833  0.64
1983 Cronin MJ, Myers GA, MacLeod RM, Hewlett EL. Pertussis toxin uncouples dopamine agonist inhibition of prolactin release. The American Journal of Physiology. 244: E499-504. PMID 6682634  0.64
1983 Hewlett EL, Roberts CO, Wolff J, Manclark CR. Biphasic effect of pertussis vaccine on serum insulin in mice Infection and Immunity. 41: 137-144. PMID 6345388  0.64
1983 Tuomanen EI, Nedelman J, Hendley JO, Hewlett EL. Species specificity of Bordetella adherence to human and animal ciliated respiratory epithelial cells Infection and Immunity. 42: 692-695. PMID 6315583  0.64
1983 Moss J, Stanley SJ, Burns DL, Hsia JA, Yost DA, Myers GA, Hewlett EL. Activation by thiol of the latent NAD glycohydrolase and ADP-ribosyltransferase activities of Bordetella pertussis toxin (islet-activating protein). The Journal of Biological Chemistry. 258: 11879-82. PMID 6311827  0.64
1983 Weiss AA, Hewlett EL, Myers GA, Falkow S. Tn5-induced mutations affecting virulence factors of Bordetella pertussis. Infection and Immunity. 42: 33-41. PMID 6311749  0.64
1983 Cronin MJ, Evans WS, Hewlett EL, Rogol AD, Thorner MO. Luteinizing hormone secretion is enhanced by pertussis toxin, cholera toxin, and forskolin: Evidence for the involvement of the cyclic amp-generating system Neuroendocrinology. 37: 161-163. PMID 6310432 DOI: 10.1159/000123535  0.64
1983 Bokoch GM, Katada T, Northup JK, Hewlett EL, Gilman AG. Identification of the predominant substrate for ADP-ribosylation by islet activating protein Journal of Biological Chemistry. 258: 2072-2075. PMID 6296122  0.64
1983 Cronin MJ, Myers GA, MacLeod RM, Hewlett EL. Pertussis toxin actions on the pituitary-derived 235-1 clone: effects of PGE1, cholera toxin, and forskolin on cyclic AMP metabolism and prolactin release. Journal of Cyclic Nucleotide and Protein Phosphorylation Research. 9: 245-58. PMID 6199389  0.64
1983 Olansky L, Myers GA, Pohl SL, Hewlett EL. Promotion of lipolysis in rat adipocytes by pertussis toxin: reversal of endogenous inhibition. Proceedings of the National Academy of Sciences of the United States of America. 80: 6547-51. PMID 6195660  0.64
1983 Cronin MJ, Rogol AD, Myers GA, Hewlett EL. Pertussis toxin blocks the somatostatin-induced inhibition of growth hormone release and adenosine 3',5'-monophosphate accumulation. Endocrinology. 113: 209-15. PMID 6134612 DOI: 10.1210/endo-113-1-209  0.64
1983 Burns DL, Hewlett EL, Moss J, Vaughan M. Pertussis toxin inhibits enkephalin stimulation of GTPase of NG108-15 cells Journal of Biological Chemistry. 258: 1435-1438. PMID 6130091  0.64
1983 Cronin MJ, Myers GA, MacLeod RM, Hewlett EL. Pertussis toxin uncouples dopamine agonist inhibition of prolactin release American Journal of Physiology - Gastrointestinal and Liver Physiology. 7.  0.64
1982 Olveda RK, Andrews JS, Hewlett EL. Murine giardiasis: Localization of trophozoites and small bowel histopathology during the course of infection American Journal of Tropical Medicine and Hygiene. 31: 60-66. PMID 7058979  0.64
1982 Hewlett EL, Andrews JS, Ruffier J, Schaefer FW. Experimental infection of mongrel dogs with giardia lamblia cysts and cultured trophozoites Journal of Infectious Diseases. 145: 89-93. PMID 7054320 DOI: 10.1093/infdis/145.1.89  0.64
1982 Pearson RD, Manian AA, Harcus JL, Hall D, Hewlett EL. Lethal effect of phenothiazine neuroleptics on the pathogenic protozoan Leishmania donovani Science. 217: 369-371. PMID 6124040 DOI: 10.1126/science.6124040  0.64
1982 Hewlett EL, Anderson H, Burns DL, Moss J. Effect of Bordetella pertussis toxin on the hormone responsiveness of neuroblastoma-glioma cells (NG108-15) Journal of Cell Biology. 95.  0.64
1981 Hewlett EL, Hamid OY, Ruffier J, Mahmoud AA. In vivo suppression of delayed hypersensitivity by thiabendazole and diethylcarbamazine. Immunopharmacology. 3: 325-32. PMID 7327923 DOI: 10.1016/0162-3109(81)90025-4  0.64
1981 Andrews JS, Hewlett EL. Protection against infection with giardia muris by milk containing antibody to giardia Journal of Infectious Diseases. 143: 242-246. PMID 7217719 DOI: 10.1093/infdis/143.2.242  0.64
1981 Hill DR, Hewlett EL, Pearson RD. Lectin binding by Giardia lamblia Infection and Immunity. 34: 733-738. PMID 6895883  0.64
1981 Goldhammer AR, Wolff J, Hope Cook G, Berkowitz SA, Klee CB, Manclark CR, Hewlett EL. Spurious protein activators of Bordetella pertussis adenylate cyclase. European Journal of Biochemistry / Febs. 115: 605-9. PMID 6263634 DOI: 10.1111/j.1432-1033.1981.tb06245.x  0.64
1980 Berkowitz SA, Goldhammer AR, Hewlett EL, Wolff J. ACTIVATION C)F PROKARYOTIC ADENYLATE CYCLASE BY CALMODULIN Annals of the New York Academy of Sciences. 356: 360-360. PMID 6263154 DOI: 10.1111/j.1749-6632.1980.tb29626.x  0.64
1979 Cowell JL, Hewlett EL, Manclark CR. Intracellular localization of the dermonecrotic toxin of Bordetella pertussis Infection and Immunity. 25: 896-901. PMID 227787  0.64
1979 Hewlett EL, Underhill LH, Cook GH, Manclark CR, Wolff J. A protein activator for the adenylate cyclase of Bordetella pertussis Journal of Biological Chemistry. 254: 5602-5605. PMID 221475  0.64
1978 Hewlett EL, Wolff J, Manclark CR. Regulation of Bordetella pertussis extracytoplasmic adenylate cyclase Advances in Cyclic Nucleotide Research. 9: 621-628. PMID 208400  0.64
1977 Hewlett EL, Manclark CR, Wolff J. Adenyl cyclase in Bordetella pertussis vaccines Journal of Infectious Diseases. 136. PMID 19542  0.64
1976 Hewlett EL, Urban MA, Manclark CR, Wolff J. Extracytoplasmic adenylate cyclase of Bordetella pertussis Proceedings of the National Academy of Sciences of the United States of America. 73: 1926-1930. PMID 180529  0.64
1974 Hewlett EL, Guerrant RL, Evans DJ, Greenough WB. Toxins of Vibrio cholerae and Escherichia coli stimulate adenyl cyclase in rat fat cells Nature. 249: 371-373. PMID 4366779 DOI: 10.1038/249371a0  0.64
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