Michael E. Selsted - Publications

Affiliations: 
University of California, Irvine, Irvine, CA 
Area:
Microbiology Biology, Molecular Biology

129 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Schaal JB, Eriguchi Y, Tran DQ, Tran PA, Hawes C, Cabebe AE, Pike K, Trinh K, Ouellette AJ, Selsted ME. A host-directed macrocyclic peptide therapeutic for MDR gram negative bacterial infections. Scientific Reports. 11: 23447. PMID 34873199 DOI: 10.1038/s41598-021-02619-y  0.33
2019 Basso V, Tran DQ, Schaal JB, Tran P, Eriguchi Y, Ngole D, Cabebe AE, Park AY, Beringer PM, Ouellette AJ, Selsted ME. Rhesus Theta Defensin 1 Promotes Long Term Survival in Systemic Candidiasis by Host Directed Mechanisms. Scientific Reports. 9: 16905. PMID 31729441 DOI: 10.1038/S41598-019-53402-Z  0.361
2018 Eriguchi Y, Nakamura K, Yokoi Y, Sugimoto R, Takahashi S, Hashimoto D, Teshima T, Ayabe T, Selsted ME, Ouellette AJ. Essential role of IFN-γ in T cell-associated intestinal inflammation. Jci Insight. 3. PMID 30232288 DOI: 10.1172/Jci.Insight.121886  0.318
2018 Basso V, Garcia A, Tran DQ, Schaal JB, Tran P, Ngole D, Aqeel Y, Tongaonkar P, Ouellette AJ, Selsted ME. Fungicidal potency and mechanisms of θ-defensins against multi-drug resistantspecies. Antimicrobial Agents and Chemotherapy. PMID 29610196 DOI: 10.1128/Aac.00111-18  0.392
2018 Schaal JB, Maretzky T, Tran DQ, Tran PA, Tongaonkar P, Blobel CP, Ouellette AJ, Selsted ME. Macrocyclic θ-defensins suppress tumor necrosis factor-α (TNF-α) shedding by inhibition of TNF-α converting enzyme. The Journal of Biological Chemistry. PMID 29317500 DOI: 10.1074/Jbc.Ra117.000793  0.344
2017 Schaal JB, Tran DQ, Subramanian A, Patel R, Laragione T, Roberts KD, Trinh K, Tongaonkar P, Tran PA, Minond D, Fields GB, Beringer P, Ouellette AJ, Gulko PS, Selsted ME. Suppression and resolution of autoimmune arthritis by rhesus θ-defensin-1, an immunomodulatory macrocyclic peptide. Plos One. 12: e0187868. PMID 29145473 DOI: 10.1371/Journal.Pone.0187868  0.38
2017 Jayne JG, Bensman TJ, Schaal JB, Park AYJ, Kimura E, Tran D, Selsted ME, Beringer PM. Rhesus Theta (θ)-Defensin-1 Attenuates Endotoxin-Induced Acute Lung Injury by Inhibiting Proinflammatory Cytokines and Neutrophil Recruitment. American Journal of Respiratory Cell and Molecular Biology. PMID 28954201 DOI: 10.1165/Rcmb.2016-0428Oc  0.341
2017 Bensman TJ, Jayne JG, Sun M, Kimura E, Meinert J, Wang JC, Schaal JB, Tran D, Rao AP, Akbari O, Selsted ME, Beringer PM. Efficacy of Rhesus Theta (θ)-Defensin-1 in Experimental Models of Pseudomonas aeruginosa Lung Infection and Inflammation. Antimicrobial Agents and Chemotherapy. PMID 28559270 DOI: 10.1128/Aac.00154-17  0.329
2015 Beringer PM, Bensman TJ, Ho H, Agnello M, Denovel N, Nguyen A, Wong-Beringer A, She R, Tran DQ, Moskowitz SM, Selsted ME. Rhesus θ-defensin-1 (RTD-1) exhibits in vitro and in vivo activity against cystic fibrosis strains of Pseudomonas aeruginosa. The Journal of Antimicrobial Chemotherapy. PMID 26433781 DOI: 10.1093/Jac/Dkv301  0.326
2015 Tongaonkar P, Trinh KK, Schaal JB, Tran D, Gulko PS, Ouellette AJ, Selsted ME. Rhesus macaque θ-defensin RTD-1 inhibits proinflammatory cytokine secretion and gene expression by inhibiting the activation of NF-κB and MAPK pathways. Journal of Leukocyte Biology. PMID 26269197 DOI: 10.1189/Jlb.3A0315-102R  0.362
2015 Tai KP, Kamdar K, Yamaki J, Le VV, Tran D, Tran P, Selsted ME, Ouellette AJ, Wong-Beringer A. Microbicidal effects of α- and θ-defensins against antibiotic-resistant Staphylococcus aureus and Pseudomonas aeruginosa. Innate Immunity. 21: 17-29. PMID 24345876 DOI: 10.1177/1753425913514784  0.351
2014 Wilmes M, Stockem M, Bierbaum G, Schlag M, Götz F, Tran DQ, Schaal JB, Ouellette AJ, Selsted ME, Sahl HG. Killing of staphylococci by θ-defensins involves membrane impairment and activation of autolytic enzymes. Antibiotics (Basel, Switzerland). 3: 617-631. PMID 25632351 DOI: 10.3390/Antibiotics3040617  0.395
2014 Mastroianni JR, Lu W, Selsted ME, Ouellette AJ. Differential Susceptibility of Bacteria to Mouse Paneth Cell α-Defensins under Anaerobic Conditions. Antibiotics (Basel, Switzerland). 3: 493-508. PMID 25383215 DOI: 10.3390/Antibiotics3040493  0.385
2014 Tai KP, Le VV, Selsted ME, Ouellette AJ. Hydrophobic determinants of α-defensin bactericidal activity. Infection and Immunity. 82: 2195-202. PMID 24614658 DOI: 10.1128/Iai.01414-13  0.419
2013 Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, ... ... Selsted ME, et al. Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Natural Product Reports. 30: 108-60. PMID 23165928 DOI: 10.1039/C2Np20085F  0.38
2013 Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, ... ... Selsted ME, et al. Erratum: Ribosomally synthesized and post-translationally modified peptide natural products: Overview and recommendations for a universal nomenclature (Natural Product Reports (2013) 30 (108-160) DOI:10.1039/C2NP20085F) Natural Product Reports. 30: 1568-1568. DOI: 10.1039/C3Np90040A  0.362
2012 Schaal JB, Tran D, Tran P, Ösapay G, Trinh K, Roberts KD, Brasky KM, Tongaonkar P, Ouellette AJ, Selsted ME. Rhesus macaque theta defensins suppress inflammatory cytokines and enhance survival in mouse models of bacteremic sepsis. Plos One. 7: e51337. PMID 23236475 DOI: 10.1371/Journal.Pone.0051337  0.408
2012 Ouellette AJ, Selsted ME. Immunology. HD6 defensin nanonets. Science (New York, N.Y.). 337: 420-1. PMID 22837514 DOI: 10.1126/Science.1225906  0.347
2012 Lehrer RI, Cole AM, Selsted ME. θ-Defensins: cyclic peptides with endless potential. The Journal of Biological Chemistry. 287: 27014-9. PMID 22700960 DOI: 10.1074/Jbc.R112.346098  0.466
2012 Tongaonkar P, Golji AE, Tran P, Ouellette AJ, Selsted ME. High fidelity processing and activation of the human α-defensin HNP1 precursor by neutrophil elastase and proteinase 3. Plos One. 7: e32469. PMID 22448222 DOI: 10.1371/Journal.Pone.0032469  0.512
2012 Mastroianni JR, Costales JK, Zaksheske J, Selsted ME, Salzman NH, Ouellette AJ. Alternative luminal activation mechanisms for paneth cell α-defensins. The Journal of Biological Chemistry. 287: 11205-12. PMID 22334698 DOI: 10.1074/Jbc.M111.333559  0.318
2012 Rapireddy S, Nhon L, Meehan RE, Franks J, Stolz DB, Tran D, Selsted ME, Ly DH. RTD-1mimic containing γPNA scaffold exhibits broad-spectrum antibacterial activities. Journal of the American Chemical Society. 134: 4041-4. PMID 22332599 DOI: 10.1021/Ja211867J  0.391
2011 Mohimani H, Liu WT, Mylne JS, Poth AG, Colgrave ML, Tran D, Selsted ME, Dorrestein PC, Pevzner PA. Cycloquest: identification of cyclopeptides via database search of their mass spectra against genome databases. Journal of Proteome Research. 10: 4505-12. PMID 21851130 DOI: 10.1021/Pr200323A  0.386
2011 Schmidt NW, Mishra A, Lai GH, Davis M, Sanders LK, Tran D, Garcia A, Tai KP, McCray PB, Ouellette AJ, Selsted ME, Wong GC. Criterion for amino acid composition of defensins and antimicrobial peptides based on geometry of membrane destabilization. Journal of the American Chemical Society. 133: 6720-7. PMID 21473577 DOI: 10.1021/Ja200079A  0.377
2011 Tongaonkar P, Tran P, Roberts K, Schaal J, Osapay G, Tran D, Ouellette AJ, Selsted ME. Rhesus macaque θ-defensin isoforms: expression, antimicrobial activities, and demonstration of a prominent role in neutrophil granule microbicidal activities. Journal of Leukocyte Biology. 89: 283-90. PMID 21084627 DOI: 10.1189/Jlb.0910535  0.468
2010 Seidel A, Ye Y, de Armas LR, Soto M, Yarosh W, Marcsisin RA, Tran D, Selsted ME, Camerini D. Cyclic and acyclic defensins inhibit human immunodeficiency virus type-1 replication by different mechanisms. Plos One. 5: e9737. PMID 20305815 DOI: 10.1371/Journal.Pone.0009737  0.327
2009 Park N, Yamanaka K, Tran D, Chandrangsu P, Akers JC, de Leon JC, Morrissette NS, Selsted ME, Tan M. The cell-penetrating peptide, Pep-1, has activity against intracellular chlamydial growth but not extracellular forms of Chlamydia trachomatis. The Journal of Antimicrobial Chemotherapy. 63: 115-23. PMID 18957395 DOI: 10.1093/Jac/Dkn436  0.474
2008 Vasudevan S, Yuan J, Osapay G, Tran P, Tai K, Liang W, Kumar V, Selsted ME, Cocco MJ. Synthesis, structure, and activities of an oral mucosal alpha-defensin from rhesus macaque. The Journal of Biological Chemistry. 283: 35869-77. PMID 18930922 DOI: 10.1074/Jbc.M806915200  0.413
2008 Garcia AE, Osapay G, Tran PA, Yuan J, Selsted ME. Isolation, synthesis, and antimicrobial activities of naturally occurring theta-defensin isoforms from baboon leukocytes. Infection and Immunity. 76: 5883-91. PMID 18852242 DOI: 10.1128/Iai.01100-08  0.463
2008 Tran D, Tran P, Roberts K, Osapay G, Schaal J, Ouellette A, Selsted ME. Microbicidal properties and cytocidal selectivity of rhesus macaque theta defensins. Antimicrobial Agents and Chemotherapy. 52: 944-53. PMID 18160518 DOI: 10.1128/Aac.01090-07  0.502
2007 Selsted ME. A pocket guide to explorations of the defensin field. Current Pharmaceutical Design. 13: 3061-4. PMID 17979748 DOI: 10.2174/138161207782110363  0.441
2006 Tydell CC, Yuan J, Tran P, Selsted ME. Bovine peptidoglycan recognition protein-S: antimicrobial activity, localization, secretion, and binding properties. Journal of Immunology (Baltimore, Md. : 1950). 176: 1154-62. PMID 16394004 DOI: 10.4049/Jimmunol.176.2.1154  0.337
2005 Selsted ME, Ouellette AJ. Mammalian defensins in the antimicrobial immune response. Nature Immunology. 6: 551-7. PMID 15908936 DOI: 10.1146/Annurev-Pathol-011811-132427  0.334
2004 Selsted ME. Theta-defensins: cyclic antimicrobial peptides produced by binary ligation of truncated alpha-defensins. Current Protein & Peptide Science. 5: 365-71. PMID 15544531 DOI: 10.2174/1389203043379459  0.463
2004 Tanabe H, Yuan J, Zaragoza MM, Dandekar S, Henschen-Edman A, Selsted ME, Ouellette AJ. Paneth cell alpha-defensins from rhesus macaque small intestine. Infection and Immunity. 72: 1470-8. PMID 14977952 DOI: 10.1128/Iai.72.3.1470-1478.2004  0.439
2004 Tanabe H, Qu X, Weeks CS, Cummings JE, Kolusheva S, Walsh KB, Jelinek R, Vanderlick TK, Selsted ME, Ouellette AJ. Structure-activity determinants in paneth cell alpha-defensins: loss-of-function in mouse cryptdin-4 by charge-reversal at arginine residue positions. The Journal of Biological Chemistry. 279: 11976-83. PMID 14702345 DOI: 10.1074/Jbc.M310251200  0.464
2004 Yamamoto CM, Banaiee N, Yount NY, Patel B, Selsted ME. Alpha-defensin expression during myelopoiesis: identification of cis and trans elements that regulate expression of NP-3 in rat promyelocytes. Journal of Leukocyte Biology. 75: 332-41. PMID 14634060 DOI: 10.1189/Jlb.0803384  0.343
2003 Satchell DP, Sheynis T, Kolusheva S, Cummings J, Vanderlick TK, Jelinek R, Selsted ME, Ouellette AJ. Quantitative interactions between cryptdin-4 amino terminal variants and membranes. Peptides. 24: 1795-805. PMID 15019212 DOI: 10.1016/J.Peptides.2003.08.020  0.431
2003 Nascimento Mda G, Cullor JS, Selsted ME. In vitro activity of naturally occurring peptides (defensins) against Listeria monocytogenes. Cadernos De Saude Publica. 10: 440-5. PMID 14676929 DOI: 10.1590/S0102-311X1994000400003  0.373
2003 Chong-Cerrillo C, Selsted ME, Peterson EM, de la Maza LM. Susceptibility of human and murine Chlamydia trachomatis serovars to granulocyte- and epithelium-derived antimicrobial peptides. The Journal of Peptide Research : Official Journal of the American Peptide Society. 61: 237-42. PMID 12662357 DOI: 10.1034/J.1399-3011.2003.00053.X  0.458
2003 Pecota DC, Osapay G, Selsted ME, Wood TK. Antimicrobial properties of the Escherichia coli R1 plasmid host killing peptide. Journal of Biotechnology. 100: 1-12. PMID 12413781 DOI: 10.1016/S0168-1656(02)00240-7  0.411
2002 Tang YQ, Yeaman MR, Selsted ME. Antimicrobial peptides from human platelets. Infection and Immunity. 70: 6524-33. PMID 12438321 DOI: 10.1128/Iai.70.12.6524-6533.2002  0.484
2002 Yue G, Merlin D, Selsted ME, Lencer WI, Madara JL, Eaton DC. Cryptdin 3 forms anion selective channels in cytoplasmic membranes of human embryonic kidney cells. American Journal of Physiology. Gastrointestinal and Liver Physiology. 282: G757-65. PMID 11960772 DOI: 10.1152/Ajpgi.00152.2001  0.33
2002 Tydell CC, Yount N, Tran D, Yuan J, Selsted ME. Isolation, characterization, and antimicrobial properties of bovine oligosaccharide-binding protein. A microbicidal granule protein of eosinophils and neutrophils. The Journal of Biological Chemistry. 277: 19658-64. PMID 11880375 DOI: 10.1074/Jbc.M200659200  0.351
2002 Tran D, Tran PA, Tang YQ, Yuan J, Cole T, Selsted ME. Homodimeric theta-defensins from rhesus macaque leukocytes: isolation, synthesis, antimicrobial activities, and bacterial binding properties of the cyclic peptides. The Journal of Biological Chemistry. 277: 3079-84. PMID 11675394 DOI: 10.1074/Jbc.M109117200  0.449
2000 Ayabe T, Satchell DP, Wilson CL, Parks WC, Selsted ME, Ouellette AJ. Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria. Nature Immunology. 1: 113-8. PMID 11248802 DOI: 10.1038/77783  0.457
2000 Mambula SS, Simons ER, Hastey R, Selsted ME, Levitz SM. Human neutrophil-mediated nonoxidative antifungal activity against Cryptococcus neoformans Infection and Immunity. 68: 6257-6264. PMID 11035733 DOI: 10.1128/Iai.68.11.6257-6264.2000  0.333
2000 Newman SL, Gootee L, Gabay JE, Selsted ME. Identification of constituents of human neutrophil azurophil granules that mediate fungistasis against Histoplasma capsulatum. Infection and Immunity. 68: 5668-72. PMID 10992469 DOI: 10.1128/Iai.68.10.5668-5672.2000  0.302
2000 Ouellette AJ, Satchell DP, Hsieh MM, Hagen SJ, Selsted ME. Characterization of luminal Paneth cell α-defensins in mouse small intestine: Attenuated antimicrobial activities of peptides with truncated amino termini Journal of Biological Chemistry. 275: 33969-33973. PMID 10942762 DOI: 10.1074/jbc.M004062200  0.419
2000 Ösapay K, Tran D, Ladokhin AS, White SH, Henschen AH, Selsted ME. Formation and characterization of a single Trp-Trp cross-link in indolicidin that confers protease stability without altering antimicrobial activity Journal of Biological Chemistry. 275: 12017-12022. PMID 10766833 DOI: 10.1074/Jbc.275.16.12017  0.444
1999 Ouellette AJ, Darmoul D, Tran D, Huttner KM, Yuan J, Selsted ME. Peptide localization and gene structure of cryptdin 4, a differentially expressed mouse Paneth cell α-defensin Infection and Immunity. 67: 6643-6651. PMID 10569786 DOI: 10.1128/Iai.67.12.6643-6651.1999  0.366
1999 Tang YQ, Yuan J, Miller CJ, Selsted ME. Isolation, characterization, cDNA cloning, and antimicrobial properties of two distinct subfamilies of α-defensins from rhesus macaque leukocytes Infection and Immunity. 67: 6139-6144. PMID 10531277 DOI: 10.1128/Iai.67.11.6139-6144.1999  0.472
1999 Tang YQ, Yuan J, Ösapay G, Ösapay K, Tran D, Miller CJ, Ouellette AJ, Selsted ME. A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated α-defensins Science. 286: 498-502. PMID 10521339 DOI: 10.1126/Science.286.5439.498  0.506
1999 Ladokhin AS, Selsted ME, White SH. CD spectra of indolicidin antimicrobial peptides suggest turns, not polyproline helix Biochemistry. 38: 12313-12319. PMID 10493799 DOI: 10.1021/Bi9907936  0.393
1998 Robinson WE, McDougall B, Tran D, Selsted ME. Anti-HIV-1 activity of indolicidin, an antimicrobial peptide from neutrophils. Journal of Leukocyte Biology. 63: 94-100. PMID 9469478 DOI: 10.1002/Jlb.63.1.94  0.351
1998 Westendorf JJ, Yamamoto CM, Lenny N, Downing JR, Selsted ME, Hiebert SW. The t(8;21) fusion product, AML-1-ETO, associates with C/EBP-α, inhibits C/EBP-α-dependent transcription, and blocks granulocytic differentiation Molecular and Cellular Biology. 18: 322-333. PMID 9418879 DOI: 10.1128/Mcb.18.1.322  0.304
1997 Hristova K, Selsted ME, White SH. Critical role of lipid composition in membrane permeabilization by rabbit neutrophil defensins Journal of Biological Chemistry. 272: 24224-24233. PMID 9305875 DOI: 10.1074/Jbc.272.39.24224  0.328
1997 Selsted ME. HPLC methods for purification of antimicrobial peptides Methods in Molecular Biology (Clifton, N.J.). 78: 17-33. PMID 9276294 DOI: 10.1385/0-89603-408-9:17  0.445
1997 Lencer WI, Cheung G, Strohmeier GR, Currie MG, Ouellette AJ, Selsted ME, Madara JL. Induction of epithelial chloride secretion by channel-forming cryptdins 2 and 3. Proceedings of the National Academy of Sciences of the United States of America. 94: 8585-9. PMID 9238020 DOI: 10.1073/Pnas.94.16.8585  0.403
1997 Ladokhin AS, Selsted ME, White SH. Sizing membrane pores in lipid vesicles by leakage of co-encapsulated markers: Pore formation by melittin Biophysical Journal. 72: 1762-1766. PMID 9083680 DOI: 10.1016/S0006-3495(97)78822-2  0.389
1997 Darmoul D, Brown D, Selsted ME, Ouellette AJ. Cryptdin gene expression in developing mouse small intestine American Journal of Physiology - Gastrointestinal and Liver Physiology. 272. PMID 9038894 DOI: 10.1152/Ajpgi.1997.272.1.G197  0.316
1997 Yeaman MR, Tang YIQ, Shen AJ, Bayer AS, Selsted ME. Purification and in vitro activities of rabbit platelet microbicidal proteins Infection and Immunity. 65: 1023-1031. PMID 9038312 DOI: 10.1128/Iai.65.3.1023-1031.1997  0.352
1997 Ladokhin AS, Selsted ME, White SH. Bilayer interactions of indolicidin, a small antimicrobial peptide rich in tryptophan, proline, and basic amino acids Biophysical Journal. 72: 794-805. PMID 9017204 DOI: 10.1016/S0006-3495(97)78713-7  0.377
1997 Ouellette AJ, Selsted ME. Enteric defensins Current Opinion in Gastroenterology. 13: 494-499.  0.373
1996 Ouellette AJ, Selsted ME. Paneth cell defensins: Endogenous peptide components of intestinal host defense Faseb Journal. 10: 1280-1289. PMID 8836041 DOI: 10.1096/Fasebj.10.11.8836041  0.477
1996 Hristova K, Selsted ME, White SH. Interactions of monomeric rabbit neutrophil defensins with bilayers: Comparison with dimeric human defensin HNP-2 Biochemistry. 35: 11888-11894. PMID 8794771 DOI: 10.1021/Bi961100D  0.344
1996 Selsted ME, Tang YQ, Morris WL, McGuire PA, Novotny MJ, Smith W, Henschen AH, Cullor JS. Purification, primary structures, and antibacterial activities of beta-defensins, a new family of antimicrobial peptides from bovine neutrophils. The Journal of Biological Chemistry. 271: 16430. PMID 8690735 DOI: 10.1074/Jbc.271.27.16430  0.507
1996 Selsted ME. Natural antimicrobial peptides: Basic science and potential applications Proceedings of the Western Pharmacology Society. 39: 93-94.  0.413
1996 Yount NY, McGuire PA, Morris WL, Tran D, Selsted ME. Characterization, synthesis, and cDNA cloning of a novel antimicrobial peptide from bovine neutrophils Journal of Investigative Medicine. 44.  0.387
1995 White SH, Wimley WC, Selsted ME. Structure, function, and membrane integration of defensins Current Opinion in Structural Biology. 5: 521-527. PMID 8528769 DOI: 10.1016/0959-440X(95)80038-7  0.417
1995 Ahmad I, Perkins WR, Lupan DM, Selsted ME, Janoff AS. Liposomal entrapment of the neutrophil-derived peptide indolicidin endows it with in vivo antifungal activity Bba - Biomembranes. 1237: 109-114. PMID 7632702 DOI: 10.1016/0005-2736(95)00087-J  0.399
1995 van Abel RJ, Tang YQ, Rao VS, Dobbs CH, Tran D, Barany G, Selsted ME. Synthesis and characterization of indolicidin, a tryptophan-rich antimicrobial peptide from bovine neutrophils. International Journal of Peptide and Protein Research. 45: 401-9. PMID 7591479 DOI: 10.1111/J.1399-3011.1995.Tb01055.X  0.404
1995 Zimmermann GR, Legault P, Selsted ME, Pardi A. Solution structure of bovine neutrophil beta-defensin-12: the peptide fold of the beta-defensins is identical to that of the classical defensins. Biochemistry. 34: 13663-71. PMID 7577957 DOI: 10.1021/Bi00041A048  0.323
1995 Selsted ME, Ouellette AJ. Defensins in granules of phagocytic and non-phagocytic cells Trends in Cell Biology. 5: 114-119. DOI: 10.1016/S0962-8924(00)88961-8  0.498
1994 Huttner KM, Selsted ME, Ouellette AJ. Structure and Diversity of the Murine Cryptdin Gene Family Genomics. 19: 448-453. PMID 8188287 DOI: 10.1006/Geno.1994.1093  0.353
1994 Aley SB, Zimmerman M, Hetsko M, Selsted ME, Gillin FD. Killing of Giardia lamblia by cryptdins and cationic neutrophil peptides Infection and Immunity. 62: 5397-5403. PMID 7960119 DOI: 10.1128/Iai.62.12.5397-5403.1994  0.511
1994 Ouellette AJ, Hsieh MM, Nosek MT, Cano-Gauci DF, Huttner KM, Buick RN, Selsted ME. Mouse Paneth cell defensins: Primary structures and antibacterial activities of numerous cryptdin isoforms Infection and Immunity. 62: 5040-5047. PMID 7927786 DOI: 10.1128/Iai.62.11.5040-5047.1994  0.503
1994 Wimley WC, Selsted ME, White SH. Interactions between human defensins and lipid bilayers: Evidence for formation of multimeric pores Protein Science. 3: 1362-1373. PMID 7833799 DOI: 10.1002/Pro.5560030902  0.356
1994 Skalicky JJ, Selsted ME, Pardi A. Structure and dynamics of the neutrophil defensins NP-2, NP-5, and HNP-1: NMR studies of amide hydrogen exchange kinetics. Proteins. 20: 52-67. PMID 7824523 DOI: 10.1002/Prot.340200107  0.314
1993 Murphy CJ, Foster BA, Mannis MJ, Selsted ME, Reid TW. Defensins are mitogenic for epithelial cells and fibroblasts. Journal of Cellular Physiology. 155: 408-13. PMID 8482733 DOI: 10.1002/Jcp.1041550223  0.479
1993 Tang YQ, Selsted ME. Characterization of the bisulfide motif in BNBD-12, an antimicrobial β-defensin peptide from bovine neutrophils Journal of Biological Chemistry. 268: 6649-6653. PMID 8454636  0.351
1993 Selsted ME, Tang YQ, Morris WL, McGuire PA, Novotny MJ, Smith W, Henschen AH, Cullor JS. Purification, primary structures, and antibacterial activities of beta-defensins, a new family of antimicrobial peptides from bovine neutrophils. The Journal of Biological Chemistry. 268: 6641-8. PMID 8454635  0.31
1993 Fujii G, Selsted ME, Eisenberg D. Defensins promote fusion and lysis of negatively charged membranes Protein Science. 2: 1301-1312. PMID 8401215 DOI: 10.1002/Pro.5560020813  0.382
1993 Selsted ME. Investigational approaches for studying the structures and biological functions of myeloid antimicrobial peptides Genetic Engineering. 15: 131-147. PMID 7763838 DOI: 10.1007/978-1-4899-1666-2_6  0.385
1992 Ouellette AJ, Miller SI, Henschen AH, Selsted ME. Purification and primary structure of murine cryptdin-1, a Paneth cell defensin Febs Letters. 304: 146-148. PMID 1618314 DOI: 10.1016/0014-5793(92)80606-H  0.454
1992 Selsted ME, Miller SI, Henschen AH, Ouellette AJ. Enteric defensins: Antibiotic peptide components of intestinal host defense Journal of Cell Biology. 118: 929-936. PMID 1500431 DOI: 10.1083/Jcb.118.4.929  0.505
1992 Pardi A, Zhang XL, Selsted ME, Skalicky JJ, Yip PF. NMR studies of defensin antimicrobial peptides. 2. Three-dimensional structures of rabbit NP-2 and human HNP-1. Biochemistry. 31: 11357-64. PMID 1445873 DOI: 10.1021/Bi00161A013  0.416
1992 Zhang XL, Selsted ME, Pardi A. NMR studies of defensin antimicrobial peptides. 1. Resonance assignment and secondary structure determination of rabbit NP-2 and human HNP-1. Biochemistry. 31: 11348-56. PMID 1445872 DOI: 10.1021/Bi00161A012  0.455
1991 Lehrer RI, Ganz T, Selsted ME. Defensins: Endogenous antibiotic peptides of animal cells Cell. 64: 229-230. PMID 1988144 DOI: 10.1016/0092-8674(91)90632-9  0.469
1991 Cullor JS, Wood S, Smith W, Panico L, Selsted ME. Bactericidal potency and mechanistic specificity of neutrophil defensins against bovine mastitis pathogens Veterinary Microbiology. 29: 49-58. PMID 1949554 DOI: 10.1016/0378-1135(91)90109-S  0.379
1990 Miyasaki KT, Bodeau AL, Ganz T, Selsted ME, Lehrer RI. In vitro sensitivity of oral, gram-negative, facultative bacteria to the bactericidal activity of human neutrophil defensins. Infection and Immunity. 58: 3934-40. PMID 2254020 DOI: 10.1128/Iai.58.12.3934-3940.1990  0.441
1990 Miller SI, Pulkkinen WS, Selsted ME, Mekalanos JJ. Characterization of defensin resistance phenotypes associated with mutations in the phoP virulence regulon of Salmonella typhimurium Infection and Immunity. 58: 3706-3710. PMID 2172166 DOI: 10.1128/Iai.58.11.3706-3710.1990  0.323
1990 Cullor JS, Mannis MJ, Murphy CJ, Smith WL, Selsted ME, Reid TW. In Vitro Antimicrobial Activity of Defensins Against Ocular Pathogens Archives of Ophthalmology. 108: 861-864. PMID 2112378 DOI: 10.1001/Archopht.1990.01070080105044  0.395
1990 Miyasaki KT, Bodeau AL, Selsted ME, Ganz T, Lehrer RI. Killing of oral, gram-negative, facultative bacteria by the rabbit defensin, NP-1. Oral Microbiology and Immunology. 5: 315-9. PMID 2098709 DOI: 10.1111/J.1399-302X.1990.Tb00432.X  0.447
1990 Kagan BL, Selsted ME, Ganz T, Lehrer RI. Antimicrobial defensin peptides form voltage-dependent ion-permeable channels in planar lipid bilayer membranes. Proceedings of the National Academy of Sciences of the United States of America. 87: 210-4. PMID 1688654 DOI: 10.1073/Pnas.87.1.210  0.43
1989 Selsted ME, Harwig SSL. Determination of the disulfide array in the human defensin HNP-2. A covalently cyclized peptide Journal of Biological Chemistry. 264: 4003-4007. PMID 2917986  0.352
1989 Lehrer RI, Barton A, Daher KA, Harwig SSL, Ganz T, Selsted ME. Interaction of human defensins with Escherichia coli. Mechanism of bactericidal activity Journal of Clinical Investigation. 84: 553-561. PMID 2668334 DOI: 10.1172/Jci114198  0.402
1989 Territo MC, Ganz T, Selsted ME, Lehrer R. Monocyte-chemotactic activity of defensins from human neutrophils Journal of Clinical Investigation. 84: 2017-2020. PMID 2592571 DOI: 10.1172/Jci114394  0.324
1989 Eisenhauer PB, Harwig SSL, Szklarek D, Ganz T, Selsted ME, Lehrer RI. Purification and antimicrobial properties of three defensins from rat neutrophils Infection and Immunity. 57: 2021-2027. PMID 2543629 DOI: 10.1128/Iai.57.7.2021-2027.1989  0.442
1988 Charp PA, Rice WG, Raynor RL, Reimund E, Kinkade JM, Ganz T, Selsted ME, Lehrer RI, Kuo JF. Inhibition of protein kinase C by defensins, antibiotic peptides from human neutrophils. Biochemical Pharmacology. 37: 951-6. PMID 3345204 DOI: 10.1016/0006-2952(88)90187-6  0.39
1988 Lehrer RI, Ganz T, Szklarek D, Selsted ME. Modulation of the in vitro candidacidal activity of human neutrophil defensins by target cell metabolism and divalent cations Journal of Clinical Investigation. 81: 1829-1835. PMID 3290255 DOI: 10.1172/Jci113527  0.415
1988 Lehrer RI, Ganz T, Selsted ME, Babior BM, Curnutte JT. Neutrophils and host defense Annals of Internal Medicine. 109: 127-142. PMID 3289431 DOI: 10.7326/0003-4819-109-2-127  0.309
1988 Lichtenstein AK, Ganz T, Nguyen TM, Selsted ME, Lehrer RI. Mechanism of target cytolysis by peptide defensins. Target cell metabolic activities, possibly involving endocytosis, are crucial for expression of cytotoxicity Journal of Immunology. 140: 2686-2694. PMID 3162745  0.323
1988 Pardi A, Hare DR, Selsted ME, Morrison RD, Bassolino DA, Bach AC. Solution structures of the rabbit neutrophil defensin NP-5. Journal of Molecular Biology. 201: 625-36. PMID 2843652 DOI: 10.1016/0022-2836(88)90643-2  0.33
1988 Lichtenstein AK, Ganz T, Selsted ME, Lehrer RI. Synergistic cytolysis mediated by hydrogen peroxide combined with peptide defensins Cellular Immunology. 114: 104-116. PMID 2836069 DOI: 10.1016/0008-8749(88)90258-4  0.383
1987 Bach AC, Selsted ME, Pardi A. Two-dimensional NMR studies of the antimicrobial peptide NP-5. Biochemistry. 26: 4389-97. PMID 3663594 DOI: 10.1021/Bi00388A030  0.396
1987 Selsted ME, Harwig SSL. Purification, primary structure, and antimicrobial activities of a guinea pig neutrophil defensin Infection and Immunity. 55: 2281-2286. PMID 3623703 DOI: 10.1128/Iai.55.9.2281-2286.1987  0.505
1987 Johnson KR, Nauseef WM, Care A, Wheelock MJ, Shane S, Hudson S, Koeffler HP, Selsted M, Miller C, Rovera G. Characterization of cDNA clones for human myeloperoxidase: Predicted amino acid sequence and evidence for multiple mRNA species Nucleic Acids Research. 15: 2013-2028. PMID 3031585 DOI: 10.1093/Nar/15.5.2013  0.3
1987 Rice W, Ganz T, Kinkade JJ, Selsted M, Lehrer R, Parmley R. Defensin-rich dense granules of human neutrophils Blood. 70: 757-765. DOI: 10.1182/Blood.V70.3.757.Bloodjournal703757  0.325
1986 Lichtenstein A, Ganz T, Selsted ME, Lehrer RI. In vitro tumor cell cytolysis mediated by peptide defensins of human and rabbit granulocytes Blood. 68: 1407-1410. PMID 3779104 DOI: 10.1182/Blood.V68.6.1407.Bloodjournal6861407  0.392
1986 Levitz SM, Selsted ME, Ganz T, Lehrer RI, Diamond RD. In vitro killing of spores and hyphae of aspergillus fumigatus and rhizopus oryzae by rabbit neutrophil cationic peptides and bronchoalveolar macrophages Journal of Infectious Diseases. 154: 483-489. PMID 3525696 DOI: 10.1093/Infdis/154.3.483  0.468
1986 Lehrer RI, Szklarek D, Ganz T, Selsted ME. Synergistic activity of rabbit granulocyte peptides against Candida albicans Infection and Immunity. 52: 902-904. PMID 3519465 DOI: 10.1128/Iai.52.3.902-904.1986  0.427
1986 Daher KA, Selsted ME, Lehrer RI. Direct inactivation of viruses by human granulocyte defensins Journal of Virology. 60: 1068-1074. PMID 3023659 DOI: 10.1128/Jvi.60.3.1068-1074.1986  0.406
1985 Selsted ME, Harwig SSL, Ganz T, Schilling JW, Lehrer RI. Primary structures of three human neutrophil defensins Journal of Clinical Investigation. 76: 1436-1439. PMID 4056036 DOI: 10.1172/Jci112121  0.481
1985 Ganz T, Sherman MP, Selsted ME, Lehrer RI. Newborn rabbit alveolar macrophages are deficient in two microbicidal cationic peptides, MCP-1 and MCP-2 American Review of Respiratory Disease. 132: 901-904. PMID 4051325 DOI: 10.1164/Arrd.1985.132.4.901  0.403
1985 Segal GP, Lehrer RI, Selsted ME. In vitro effect of phagocyte cationic peptides on coccidioides immitis Journal of Infectious Diseases. 151: 890-894. PMID 3989323 DOI: 10.1093/Infdis/151.5.890  0.489
1985 Sorrell TC, Lehrer RI, Ferrari LG, Müller M, Selsted ME. Divergent expression of cytotoxic and microbicidal functions of rabbit alveolar and peritoneal macrophages: Effects of non-specific activation and a natural microbicidal peptide, MCP-1 Australian Journal of Experimental Biology and Medical Science. 63: 53-63. PMID 3893405 DOI: 10.1038/Icb.1985.6  0.371
1985 Lehrer RI, Szklarek D, Ganz T, Selsted ME. Correlation of binding of rabbit granulocyte peptides to Candida albicans with candidacidal activity Infection and Immunity. 49: 207-211. PMID 3891625 DOI: 10.1128/Iai.49.1.207-211.1985  0.362
1985 Selsted ME, Szklarek D, Ganz T, Lehrer RI. Activity of rabbit leukocyte peptides against Candida albicans Infection and Immunity. 49: 202-206. PMID 3891624 DOI: 10.1128/Iai.49.1.202-206.1985  0.412
1985 Fleischmann J, Selsted ME, Lehrer RI. Opsonic activity of MCP-1 and MCP-2, cationic peptides from rabbit alveolar macrophages Diagnostic Microbiology and Infectious Disease. 3: 233-242. PMID 3888509 DOI: 10.1016/0732-8893(85)90035-5  0.459
1985 Ganz T, Selsted ME, Szklarek D, Harwig SS, Daher K, Bainton DF, Lehrer RI. Defensins. Natural peptide antibiotics of human neutrophils Journal of Clinical Investigation. 76: 1427-1435. PMID 2997278 DOI: 10.1172/Jci112120  0.476
1985 Lehrer RI, Daher K, Ganz T, Selsted ME. Direct inactivation of viruses by MCP-1 and MCP-2, natural peptide antibiotics from rabbit leukocytes Journal of Virology. 54: 467-472. PMID 2985808 DOI: 10.1128/Jvi.54.2.467-472.1985  0.447
1985 Selsted ME, Ganz T, Schilling JW, Lehrer RI. Biochemical characterization of 'defensins': Novel antibiotic peptides from human leukocytes Federation Proceedings. 44.  0.376
1985 Ganz T, Selsted ME, Szklarek D, Lehrer RI. Antimicrobial properties of human defensins: Major peptides of human neutrophils Federation Proceedings. 44.  0.335
1984 Selsted ME, Szklarek D, Lehrer RI. Purification and antibacterial activity of antimicrobial peptides of rabbit granulocytes Infection and Immunity. 45: 150-154. DOI: 10.1128/Iai.45.1.150-154.1984  0.464
1983 Selsted ME, Brown DM, DeLange RJ, Lehrer RI. Primary structures of MCP-1 and MCP-2, natural peptide antibiotics of rabbit lung macrophages. The Journal of Biological Chemistry. 258: 14485-9. PMID 6643497  0.327
1983 Lehrer RI, Selsted ME, Szklarek D, Fleischmann J. Antibacterial activity of microbicidal cationic proteins 1 and 2, natural peptide antibiotics of rabbit lung macrophages Infection and Immunity. 42: 10-14. PMID 6413408 DOI: 10.1128/Iai.42.1.10-14.1983  0.446
1982 Selsted ME, Martinez RJ. Isolation and purification of bactericides from human tears. Experimental Eye Research. 34: 305-18. PMID 7067743 DOI: 10.1016/0014-4835(82)90079-3  0.352
1981 Lehrer RI, Szklarek D, Selsted ME, Fleischmann J. Increased content of microbicidal cationic peptides in rabbit alveolar macrophages elicited by complete Freund adjuvant Infection and Immunity. 33: 775-778. PMID 7287180 DOI: 10.1128/Iai.33.3.775-778.1981  0.332
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