H. Ronald Kaback - Publications

Affiliations: 
University of California, Los Angeles, Los Angeles, CA 
Area:
Kabackosomes
Website:
http://149.142.237.181/index.html

259 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Kumar H, Finer-Moore J, Smirnova I, Kasho V, Pardon E, Steyaert J, Kaback HR, Stroud RM. Diversity in kinetics correlated with structure in nano body-stabilized LacY. Plos One. 15: e0232846. PMID 32380514 DOI: 10.1371/journal.pone.0232846  1
2019 Jiang X, Ermolova N, Lim J, Choi SW, Kaback HR. The proton electrochemical gradient induces a kinetic asymmetry in the symport cycle of LacY. Proceedings of the National Academy of Sciences of the United States of America. PMID 31889006 DOI: 10.1073/pnas.1916563117  1
2019 Kaback HR, Guan L. It takes two to tango: The dance of the permease. The Journal of General Physiology. PMID 31147449 DOI: 10.1085/jgp.201912377  0.96
2019 Serdiuk T, Steudle A, Mari SA, Manioglu S, Kaback HR, Kuhn A, Müller DJ. Insertion and folding pathways of single membrane proteins guided by translocases and insertases. Science Advances. 5: eaau6824. PMID 30801000 DOI: 10.1126/sciadv.aau6824  1
2018 Kumar H, Finer-Moore JS, Jiang X, Smirnova I, Kasho V, Pardon E, Steyaert J, Kaback HR, Stroud RM. Crystal Structure of a ligand-bound LacY-Nanobody Complex. Proceedings of the National Academy of Sciences of the United States of America. PMID 30108145 DOI: 10.1073/pnas.1801774115  1
2018 Smirnova I, Kasho V, Jiang X, Chen HM, Withers SG, Kaback HR. Oversized galactosides as a probe for conformational dynamics in LacY. Proceedings of the National Academy of Sciences of the United States of America. PMID 29602806 DOI: 10.1073/pnas.1800706115  1
2017 Smirnova IN, Kasho VN, Jiang X, Kaback HR. An asymmetric conformational change in LacY. Biochemistry. PMID 28300394 DOI: 10.1021/acs.biochem.7b00134  1
2016 Jiang X, Smirnova I, Kasho V, Wu J, Hirata K, Ke M, Pardon E, Steyaert J, Yan N, Kaback HR. Crystal structure of a LacY-nanobody complex in a periplasmic-open conformation. Proceedings of the National Academy of Sciences of the United States of America. PMID 27791182 DOI: 10.1073/pnas.1615414113  1
2016 Hariharan P, Andersson M, Jiang X, Pardon E, Steyaert J, Kaback HR, Guan L. Thermodynamics of nanobody binding to lactose permease. Biochemistry. PMID 27686537 DOI: 10.1021/acs.biochem.6b00826  1
2016 Serdiuk T, Balasubramaniam D, Sugihara J, Mari SA, Kaback HR, Müller DJ. YidC assists the stepwise and stochastic folding of membrane proteins. Nature Chemical Biology. 12: 911-917. PMID 27595331 DOI: 10.1038/nchembio.2169  1
2016 Jiang X, Andersson M, Chau BT, Wong LY, Villafuerte MK, Kaback HR. Role of conserved Gly-Gly pairs on the periplasmic side of LacY. Biochemistry. PMID 27438891 DOI: 10.1021/acs.biochem.6b00666  1
2016 Bazzone A, Madej MG, Kaback HR, Fendler K. pH Regulation of Electrogenic Sugar/H+ Symport in MFS Sugar Permeases. Plos One. 11: e0156392. PMID 27227677 DOI: 10.1371/journal.pone.0156392  1
2015 Smirnova I, Kasho V, Jiang X, Pardon E, Steyaert J, Kaback HR. Transient conformers of LacY are trapped by nanobodies. Proceedings of the National Academy of Sciences of the United States of America. PMID 26512108 DOI: 10.1073/pnas.1519485112  1
2015 Kumar H, Finer-Moore JS, Kaback HR, Stroud RM. Structure of LacY with an α-substituted galactoside: Connecting the binding site to the protonation site. Proceedings of the National Academy of Sciences of the United States of America. 112: 9004-9. PMID 26157133 DOI: 10.1073/pnas.1509854112  1
2015 Serdiuk T, Sugihara J, Mari SA, Kaback HR, Müller DJ. Observing a lipid-dependent alteration in single lactose permeases. Structure (London, England : 1993). 23: 754-61. PMID 25800555 DOI: 10.1016/j.str.2015.02.009  1
2015 Hariharan P, Balasubramaniam D, Peterkofsky A, Kaback HR, Guan L. Thermodynamic mechanism for inhibition of lactose permease by the phosphotransferase protein IIAGlc. Proceedings of the National Academy of Sciences of the United States of America. 112: 2407-12. PMID 25675534 DOI: 10.1073/pnas.1500891112  1
2015 Kaback HR. A chemiosmotic mechanism of symport. Proceedings of the National Academy of Sciences of the United States of America. 112: 1259-64. PMID 25568085 DOI: 10.1073/pnas.1419325112  1
2014 Smirnova I, Kasho V, Jiang X, Pardon E, Steyaert J, Kaback HR. Outward-facing conformers of LacY stabilized by nanobodies. Proceedings of the National Academy of Sciences of the United States of America. 111: 18548-53. PMID 25512549 DOI: 10.1073/pnas.1422265112  1
2014 Smirnova I, Kasho V, Kaback HR. Real-time conformational changes in LacY. Proceedings of the National Academy of Sciences of the United States of America. 111: 8440-5. PMID 24872451 DOI: 10.1073/pnas.1408374111  1
2014 Serdiuk T, Madej MG, Sugihara J, Kawamura S, Mari SA, Kaback HR, Müller DJ. Substrate-induced changes in the structural properties of LacY. Proceedings of the National Academy of Sciences of the United States of America. 111: E1571-80. PMID 24711390 DOI: 10.1073/pnas.1404446111  1
2014 Madej MG, Sun L, Yan N, Kaback HR. Functional architecture of MFS D-glucose transporters. Proceedings of the National Academy of Sciences of the United States of America. 111: E719-27. PMID 24550316 DOI: 10.1073/pnas.1400336111  1
2014 Jiang X, Villafuerte MK, Andersson M, White SH, Kaback HR. Galactoside-binding site in LacY. Biochemistry. 53: 1536-43. PMID 24520888 DOI: 10.1021/bi401716z  1
2014 Kumar H, Kasho V, Smirnova I, Finer-Moore JS, Kaback HR, Stroud RM. Structure of sugar-bound LacY. Proceedings of the National Academy of Sciences of the United States of America. 111: 1784-8. PMID 24453216 DOI: 10.1073/pnas.1324141111  1
2014 Ethayathulla AS, Yousef MS, Amin A, Leblanc G, Kaback HR, Guan L. Structure-based mechanism for Na(+)/melibiose symport by MelB. Nature Communications. 5: 3009. PMID 24389923 DOI: 10.1038/ncomms4009  1
2013 Madej MG, Kaback HR. Evolutionary mix-and-match with MFS transporters II. Proceedings of the National Academy of Sciences of the United States of America. 110: E4831-8. PMID 24259711 DOI: 10.1073/pnas.1319754110  1
2013 Gaiko O, Bazzone A, Fendler K, Kaback HR. Electrophysiological characterization of uncoupled mutants of LacY. Biochemistry. 52: 8261-6. PMID 24152072 DOI: 10.1021/bi4013269  1
2013 Zhu L, Kaback HR, Dalbey RE. YidC protein, a molecular chaperone for LacY protein folding via the SecYEG protein machinery. The Journal of Biological Chemistry. 288: 28180-94. PMID 23928306 DOI: 10.1074/jbc.M113.491613  1
2013 Smirnova I, Kasho V, Sugihara J, Kaback HR. Trp replacements for tightly interacting Gly-Gly pairs in LacY stabilize an outward-facing conformation. Proceedings of the National Academy of Sciences of the United States of America. 110: 8876-81. PMID 23671103 DOI: 10.1073/pnas.1306849110  1
2012 Smirnova I, Kasho V, Sugihara J, Vázquez-Ibar JL, Kaback HR. Role of protons in sugar binding to LacY. Proceedings of the National Academy of Sciences of the United States of America. 109: 16835-40. PMID 23033496 DOI: 10.1073/pnas.1214890109  1
2012 Madej MG, Soro SN, Kaback HR. Apo-intermediate in the transport cycle of lactose permease (LacY). Proceedings of the National Academy of Sciences of the United States of America. 109: E2970-8. PMID 23012238 DOI: 10.1073/pnas.1211183109  1
2012 Andersson M, Bondar AN, Freites JA, Tobias DJ, Kaback HR, White SH. Proton-coupled dynamics in lactose permease. Structure (London, England : 1993). 20: 1893-904. PMID 23000385 DOI: 10.1016/j.str.2012.08.021  1
2012 Sugihara J, Sun L, Yan N, Kaback HR. Dynamics of the L-fucose/H+ symporter revealed by fluorescence spectroscopy. Proceedings of the National Academy of Sciences of the United States of America. 109: 14847-51. PMID 22930818 DOI: 10.1073/pnas.1213445109  1
2012 Zhou Y, Jiang X, Kaback HR. Role of the irreplaceable residues in the LacY alternating access mechanism. Proceedings of the National Academy of Sciences of the United States of America. 109: 12438-42. PMID 22802658 DOI: 10.1073/pnas.1210684109  1
2012 Jiang X, Guan L, Zhou Y, Hong WX, Zhang Q, Kaback HR. Evidence for an intermediate conformational state of LacY. Proceedings of the National Academy of Sciences of the United States of America. 109: E698-704. PMID 22355148 DOI: 10.1073/pnas.1201107109  1
2011 Sugihara J, Smirnova I, Kasho V, Kaback HR. Sugar recognition by CscB and LacY. Biochemistry. 50: 11009-14. PMID 22106930 DOI: 10.1021/bi201592y  1
2011 Smirnova I, Kasho V, Kaback HR. Lactose permease and the alternating access mechanism. Biochemistry. 50: 9684-93. PMID 21995338 DOI: 10.1021/bi2014294  1
2011 Smirnova I, Kasho V, Sugihara J, Kaback HR. Opening the periplasmic cavity in lactose permease is the limiting step for sugar binding. Proceedings of the National Academy of Sciences of the United States of America. 108: 15147-51. PMID 21896727 DOI: 10.1073/pnas.1112157108  1
2011 Zhou Y, Madej MG, Guan L, Nie Y, Kaback HR. An early event in the transport mechanism of LacY protein: interaction between helices V and I. The Journal of Biological Chemistry. 286: 30415-22. PMID 21730060 DOI: 10.1074/jbc.M111.268433  1
2011 Chaptal V, Kwon S, Sawaya MR, Guan L, Kaback HR, Abramson J. Crystal structure of lactose permease in complex with an affinity inactivator yields unique insight into sugar recognition. Proceedings of the National Academy of Sciences of the United States of America. 108: 9361-6. PMID 21593407 DOI: 10.1073/pnas.1105687108  1
2011 Jiang X, Nie Y, Kaback HR. Site-directed alkylation studies with LacY provide evidence for the alternating access model of transport. Biochemistry. 50: 1634-40. PMID 21254783 DOI: 10.1021/bi101988s  1
2011 Kaback HR, Smirnova I, Kasho V, Nie Y, Zhou Y. The alternating access transport mechanism in LacY. The Journal of Membrane Biology. 239: 85-93. PMID 21161516 DOI: 10.1007/s00232-010-9327-5  1
2010 Garcia-Celma JJ, Ploch J, Smirnova I, Kaback HR, Fendler K. Delineating electrogenic reactions during lactose/H+ symport. Biochemistry. 49: 6115-21. PMID 20568736 DOI: 10.1021/bi100492p  1
2010 Nie Y, Kaback HR. Sugar binding induces the same global conformational change in purified LacY as in the native bacterial membrane. Proceedings of the National Academy of Sciences of the United States of America. 107: 9903-8. PMID 20457922 DOI: 10.1073/pnas.1004515107  1
2010 Liu Z, Madej MG, Kaback HR. Helix dynamics in LacY: helices II and IV. Journal of Molecular Biology. 396: 617-26. PMID 20043916 DOI: 10.1016/j.jmb.2009.12.044  1
2009 Smirnova I, Kasho V, Sugihara J, Kaback HR. Probing of the rates of alternating access in LacY with Trp fluorescence. Proceedings of the National Academy of Sciences of the United States of America. 106: 21561-6. PMID 19959662 DOI: 10.1073/pnas.0911434106  1
2009 Zhou Y, Nie Y, Kaback HR. Residues gating the periplasmic pathway of LacY. Journal of Molecular Biology. 394: 219-25. PMID 19781551 DOI: 10.1016/j.jmb.2009.09.043  1
2009 Guan L, Kaback HR. Properties of a LacY efflux mutant. Biochemistry. 48: 9250-5. PMID 19719233 DOI: 10.1021/bi9014067  1
2009 Smirnova I, Kasho V, Sugihara J, Choe JY, Kaback HR. Residues in the H+ translocation site define the pKa for sugar binding to LacY. Biochemistry. 48: 8852-60. PMID 19689129 DOI: 10.1021/bi9011918  1
2009 Garcia-Celma JJ, Smirnova IN, Kaback HR, Fendler K. Electrophysiological characterization of LacY. Proceedings of the National Academy of Sciences of the United States of America. 106: 7373-8. PMID 19383792 DOI: 10.1073/pnas.0902471106  1
2009 Stroud RM, Choe S, Holton J, Kaback HR, Kwiatkowski W, Minor DL, Riek R, Sali A, Stahlberg H, Harries W. 2007 annual progress report synopsis of the Center for Structures of Membrane Proteins. Journal of Structural and Functional Genomics. 10: 193-208. PMID 19148774 DOI: 10.1007/s10969-008-9058-3  1
2009 Nie Y, Zhou Y, Kaback HR. Clogging the periplasmic pathway in LacY. Biochemistry. 48: 738-43. PMID 19128028 DOI: 10.1021/bi801976r  1
2008 Smirnova IN, Kasho V, Kaback HR. Protonation and sugar binding to LacY. Proceedings of the National Academy of Sciences of the United States of America. 105: 8896-901. PMID 18567672 DOI: 10.1073/pnas.0803577105  1
2008 Nie Y, Sabetfard FE, Kaback HR. The Cys154-->Gly mutation in LacY causes constitutive opening of the hydrophilic periplasmic pathway. Journal of Molecular Biology. 379: 695-703. PMID 18485365 DOI: 10.1016/j.jmb.2008.04.015  1
2008 Zhou Y, Guan L, Freites JA, Kaback HR. Opening and closing of the periplasmic gate in lactose permease. Proceedings of the National Academy of Sciences of the United States of America. 105: 3774-8. PMID 18319336 DOI: 10.1073/pnas.0800825105  1
2008 Dong Y, Palmer SR, Hasona A, Nagamori S, Kaback HR, Dalbey RE, Brady LJ. Functional overlap but lack of complete cross-complementation of Streptococcus mutans and Escherichia coli YidC orthologs. Journal of Bacteriology. 190: 2458-69. PMID 18178746 DOI: 10.1128/JB.01366-07  1
2007 Smirnova I, Kasho V, Choe JY, Altenbach C, Hubbell WL, Kaback HR. Sugar binding induces an outward facing conformation of LacY. Proceedings of the National Academy of Sciences of the United States of America. 104: 16504-9. PMID 17925435 DOI: 10.1073/pnas.0708258104  1
2007 Nie Y, Ermolova N, Kaback HR. Site-directed alkylation of LacY: effect of the proton electrochemical gradient. Journal of Molecular Biology. 374: 356-64. PMID 17920075 DOI: 10.1016/j.jmb.2007.09.006  1
2007 Guan L, Mirza O, Verner G, Iwata S, Kaback HR. Structural determination of wild-type lactose permease. Proceedings of the National Academy of Sciences of the United States of America. 104: 15294-8. PMID 17881559 DOI: 10.1073/pnas.0707688104  1
2007 Guan L, Kaback HR. Site-directed alkylation of cysteine to test solvent accessibility of membrane proteins. Nature Protocols. 2: 2012-7. PMID 17703213 DOI: 10.1038/nprot.2007.275  0.96
2007 Majumdar DS, Smirnova I, Kasho V, Nir E, Kong X, Weiss S, Kaback HR. Single-molecule FRET reveals sugar-induced conformational dynamics in LacY. Proceedings of the National Academy of Sciences of the United States of America. 104: 12640-5. PMID 17502603 DOI: 10.1073/pnas.0700969104  1
2007 Shimohata N, Nagamori S, Akiyama Y, Kaback HR, Ito K. SecY alterations that impair membrane protein folding and generate a membrane stress. The Journal of Cell Biology. 176: 307-17. PMID 17242069 DOI: 10.1083/jcb.200611121  1
2007 Kaback HR, Dunten R, Frillingos S, Venkatesan P, Kwaw I, Zhang W, Ermolova N. Site-directed alkylation and the alternating access model for LacY. Proceedings of the National Academy of Sciences of the United States of America. 104: 491-4. PMID 17172438 DOI: 10.1073/pnas.0609968104  1
2006 Smirnova IN, Kasho VN, Kaback HR. Direct sugar binding to LacY measured by resonance energy transfer. Biochemistry. 45: 15279-87. PMID 17176050 DOI: 10.1021/bi061632m  1
2006 Nie Y, Smirnova I, Kasho V, Kaback HR. Energetics of ligand-induced conformational flexibility in the lactose permease of Escherichia coli. The Journal of Biological Chemistry. 281: 35779-84. PMID 17003033 DOI: 10.1074/jbc.M607232200  1
2006 Guan L, Kaback HR. Lessons from lactose permease. Annual Review of Biophysics and Biomolecular Structure. 35: 67-91. PMID 16689628 DOI: 10.1146/annurev.biophys.35.040405.102005  1
2006 Kasho VN, Smirnova IN, Kaback HR. Sequence alignment and homology threading reveals prokaryotic and eukaryotic proteins similar to lactose permease. Journal of Molecular Biology. 358: 1060-70. PMID 16574153 DOI: 10.1016/j.jmb.2006.02.049  1
2006 Ermolova N, Madhvani RV, Kaback HR. Site-directed alkylation of cysteine replacements in the lactose permease of Escherichia coli: helices I, III, VI, and XI. Biochemistry. 45: 4182-9. PMID 16566592 DOI: 10.1021/bi052631h  1
2006 Mirza O, Guan L, Verner G, Iwata S, Kaback HR. Structural evidence for induced fit and a mechanism for sugar/H+ symport in LacY. The Embo Journal. 25: 1177-83. PMID 16525509 DOI: 10.1038/sj.emboj.7601028  1
2006 Guan L, Smirnova IN, Verner G, Nagamori S, Nagamoni S, Kaback HR. Manipulating phospholipids for crystallization of a membrane transport protein. Proceedings of the National Academy of Sciences of the United States of America. 103: 1723-6. PMID 16446422 DOI: 10.1073/pnas.0510922103  1
2005 Kaback HR. Structure and mechanism of the lactose permease. Comptes Rendus Biologies. 328: 557-67. PMID 15950162 DOI: 10.1016/j.crvi.2005.03.008  1
2005 Ermolova NV, Smirnova IN, Kasho VN, Kaback HR. Interhelical packing modulates conformational flexibility in the lactose permease of Escherichia coli. Biochemistry. 44: 7669-77. PMID 15909981 DOI: 10.1021/bi0502801  1
2005 van Bloois E, Nagamori S, Koningstein G, Ullers RS, Preuss M, Oudega B, Harms N, Kaback HR, Herrmann JM, Luirink J. The Sec-independent function of Escherichia coli YidC is evolutionary-conserved and essential. The Journal of Biological Chemistry. 280: 12996-3003. PMID 15671040 DOI: 10.1074/jbc.M414094200  1
2005 Weinglass AB, Soskine M, Vazquez-Ibar JL, Whitelegge JP, Faull KF, Kaback HR, Schuldiner S. Exploring the role of a unique carboxyl residue in EmrE by mass spectrometry. The Journal of Biological Chemistry. 280: 7487-92. PMID 15623511 DOI: 10.1074/jbc.M413555200  1
2004 Weinglass AB, Whitelegge JP, Kaback HR. Integrating mass spectrometry into membrane protein drug discovery. Current Opinion in Drug Discovery & Development. 7: 589-99. PMID 15503862  1
2004 Abramson J, Iwata S, Kaback HR. Lactose permease as a paradigm for membrane transport proteins (Review). Molecular Membrane Biology. 21: 227-36. PMID 15371012 DOI: 10.1080/09687680410001716862  1
2004 Vázquez-Ibar JL, Guan L, Weinglass AB, Verner G, Gordillo R, Kaback HR. Sugar recognition by the lactose permease of Escherichia coli. The Journal of Biological Chemistry. 279: 49214-21. PMID 15364943 DOI: 10.1074/jbc.M407408200  1
2004 Abramson J, Kaback HR, Iwata S. Structural comparison of lactose permease and the glycerol-3-phosphate antiporter: members of the major facilitator superfamily. Current Opinion in Structural Biology. 14: 413-9. PMID 15313234 DOI: 10.1016/j.sbi.2004.07.005  1
2004 Guan L, Kaback HR. Binding affinity of lactose permease is not altered by the H+ electrochemical gradient. Proceedings of the National Academy of Sciences of the United States of America. 101: 12148-52. PMID 15304639 DOI: 10.1073/pnas.0404936101  1
2004 Weinglass A, Whitelegge JP, Faull KF, Kaback HR. Monitoring conformational rearrangements in the substrate-binding site of a membrane transport protein by mass spectrometry. The Journal of Biological Chemistry. 279: 41858-65. PMID 15272008 DOI: 10.1074/jbc.M407555200  1
2004 Vardy E, Arkin IT, Gottschalk KE, Kaback HR, Schuldiner S. Structural conservation in the major facilitator superfamily as revealed by comparative modeling. Protein Science : a Publication of the Protein Society. 13: 1832-40. PMID 15215526 DOI: 10.1110/ps.04657704  1
2004 Nagamori S, Smirnova IN, Kaback HR. Role of YidC in folding of polytopic membrane proteins. The Journal of Cell Biology. 165: 53-62. PMID 15067017 DOI: 10.1083/jcb.200402067  1
2004 Sun J, Savva CG, Deaton J, Kaback HR, Svrakic M, Young RF, Holzenburg A. Visualization of membrane proteins in GroEL Microscopy and Microanalysis. 10: 232-233. DOI: 10.1017/S1431927604881297  1
2004 Iwata S, Kaback HR. Membranes: A new era in membrane protein studies Current Opinion in Structural Biology. 14: 387-389. DOI: 10.1016/j.sbi.2004.07.009  1
2003 Abramson J, Smirnova I, Kasho V, Verner G, Iwata S, Kaback HR. The lactose permease of Escherichia coli: overall structure, the sugar-binding site and the alternating access model for transport. Febs Letters. 555: 96-101. PMID 14630326 DOI: 10.1016/S0014-5793(03)01087-1  1
2003 Vázquez-Ibar JL, Guan L, Svrakic M, Kaback HR. Exploiting luminescence spectroscopy to elucidate the interaction between sugar and a tryptophan residue in the lactose permease of Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 100: 12706-11. PMID 14566061 DOI: 10.1073/pnas.1835645100  1
2003 Ermolova N, Guan L, Kaback HR. Intermolecular thiol cross-linking via loops in the lactose permease of Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 100: 10187-92. PMID 12934015 DOI: 10.1073/pnas.1434239100  1
2003 Abramson J, Smirnova I, Kasho V, Verner G, Kaback HR, Iwata S. Structure and mechanism of the lactose permease of Escherichia coli. Science (New York, N.Y.). 301: 610-5. PMID 12893935 DOI: 10.1126/science.1088196  1
2003 Sondej M, Vázquez-Ibar JL, Farshidi A, Peterkofsky A, Kaback HR. Characterization of a lactose permease mutant that binds IIAGlc in the absence of ligand. Biochemistry. 42: 9153-9. PMID 12885249 DOI: 10.1021/bi034406a  1
2003 Zhang W, Hu Y, Kaback HR. Site-directed sulfhydryl labeling of helix IX in the lactose permease of Escherichia coli. Biochemistry. 42: 4904-8. PMID 12718531 DOI: 10.1021/bi034078e  1
2003 Weinglass AB, Whitelegge JP, Hu Y, Verner GE, Faull KF, Kaback HR. Elucidation of substrate binding interactions in a membrane transport protein by mass spectrometry. The Embo Journal. 22: 1467-77. PMID 12660154 DOI: 10.1093/emboj/cdg145  1
2003 Smirnova IN, Kaback HR. A mutation in the lactose permease of Escherichia coli that decreases conformational flexibility and increases protein stability. Biochemistry. 42: 3025-31. PMID 12627968 DOI: 10.1021/bi027329c  1
2003 Nagamori S, Vázquez-Ibar JL, Weinglass AB, Kaback HR. In vitro synthesis of lactose permease to probe the mechanism of membrane insertion and folding. The Journal of Biological Chemistry. 278: 14820-6. PMID 12590141 DOI: 10.1074/jbc.M300332200  1
2003 Guan L, Hu Y, Kaback HR. Aromatic stacking in the sugar binding site of the lactose permease. Biochemistry. 42: 1377-82. PMID 12578349 DOI: 10.1021/bi027152m  1
2003 Guan L, Sahin-Tóth M, Kálai T, Hideg K, Kaback HR. Probing the mechanism of a membrane transport protein with affinity inactivators. The Journal of Biological Chemistry. 278: 10641-8. PMID 12471022 DOI: 10.1074/jbc.M211355200  1
2002 Sorgen PL, Hu Y, Guan L, Kaback HR, Girvin ME. An approach to membrane protein structure without crystals. Proceedings of the National Academy of Sciences of the United States of America. 99: 14037-40. PMID 12391320 DOI: 10.1073/pnas.182552199  1
2002 Sahin-Tóth M, Gunawan P, Lawrence MC, Toyokuni T, Kaback HR. Binding of hydrophobic D-galactopyranosides to the lactose permease of Escherichia coli. Biochemistry. 41: 13039-45. PMID 12390031 DOI: 10.1021/bi0203076  1
2002 le Coutre J, Turk E, Kaback HR, Wright EM. Ligand-induced differences in secondary structure of the Vibrio parahaemolyticus Na+/galactose cotransporter. Biochemistry. 41: 8082-6. PMID 12069600 DOI: 10.1021/bi025692d  1
2002 Guan L, Sahin-Toth M, Kaback HR. Changing the lactose permease of Escherichia coli into a galactose-specific symporter. Proceedings of the National Academy of Sciences of the United States of America. 99: 6613-8. PMID 12011425 DOI: 10.1073/pnas.102178299  1
2002 Sondej M, Weinglass AB, Peterkofsky A, Kaback HR. Binding of enzyme IIAGlc, a component of the phosphoenolpyruvate:sugar phosphotransferase system, to the Escherichia coli lactose permease. Biochemistry. 41: 5556-65. PMID 11969416 DOI: 10.1021/bi011990j  1
2002 Guan L, Murphy FD, Kaback HR. Surface-exposed positions in the transmembrane helices of the lactose permease of Escherichia coli determined by intermolecular thiol cross-linking. Proceedings of the National Academy of Sciences of the United States of America. 99: 3475-80. PMID 11904412 DOI: 10.1073/pnas.052703699  1
2002 Vázquez-Ibar JL, Weinglass AB, Kaback HR. Engineering a terbium-binding site into an integral membrane protein for luminescence energy transfer. Proceedings of the National Academy of Sciences of the United States of America. 99: 3487-92. PMID 11891311 DOI: 10.1073/pnas.052703599  1
2002 Weinglass AB, Sondej M, Kaback HR. Manipulating conformational equilibria in the lactose permease of Escherichia coli. Journal of Molecular Biology. 315: 561-71. PMID 11812130 DOI: 10.1006/jmbi.2001.5289  1
2002 Zhang W, Guan L, Kaback HR. Helices VII and X in the lactose permease of Escherichia coli: proximity and ligand-induced distance changes. Journal of Molecular Biology. 315: 53-62. PMID 11771965 DOI: 10.1006/jmbi.2001.5206  1
2002 Weinglass AB, Whitelegge JP, Hu Y, Faull KF, Kaback HR. Exploiting mass spectrometry for mechanistic studies of an integral membrane protein Proceedings 50th Asms Conference On Mass Spectrometry and Allied Topics. 105-106.  1
2001 Sahin-Tóth M, Lawrence MC, Nishio T, Kaback HR. The C-4 hydroxyl group of galactopyranosides is the major determinant for ligand recognition by the lactose permease of Escherichia coli. Biochemistry. 40: 13015-9. PMID 11669639 DOI: 10.1021/bi011233l  1
2001 Guan L, Weinglass AB, Kaback HR. Helix packing in the lactose permease of Escherichia coli: localization of helix VI. Journal of Molecular Biology. 312: 69-77. PMID 11545586 DOI: 10.1006/jmbi.2001.4933  1
2001 Kwaw I, Zen KC, Hu Y, Kaback HR. Site-directed sulfhydryl labeling of the lactose permease of Escherichia coli: helices IV and V that contain the major determinants for substrate binding. Biochemistry. 40: 10491-9. PMID 11523990 DOI: 10.1021/bi010866x  1
2001 Kaback HR, Sahin-Tóth M, Weinglass AB. The kamikaze approach to membrane transport. Nature Reviews. Molecular Cell Biology. 2: 610-20. PMID 11483994 DOI: 10.1038/35085077  1
2001 Sahin-Toth M, Kaback HR. Arg-302 facilitates deprotonation of Glu-325 in the transport mechanism of the lactose permease from Escherichiacoli. Proceedings of the National Academy of Sciences of the United States of America. 98: 6068-73. PMID 11353849 DOI: 10.1073/pnas.111139698  1
2001 Wolin CD, Kaback HR. Functional estimation of loop-helix boundaries in the lactose permease of Escherichia coli by single amino acid deletion analysis. Biochemistry. 40: 1996-2003. PMID 11329266 DOI: 10.1021/bi0025767  1
2001 Voss J, Wu J, Hubbell WL, Jacques V, Meares CF, Kaback HR. Helix packing in the lactose permease of Escherichia coli: distances between site-directed nitroxides and a lanthanide. Biochemistry. 40: 3184-8. PMID 11258934 DOI: 10.1021/bi002333e  1
2001 Weinglass AB, Smirnova IN, Kaback HR. Engineering conformational flexibility in the lactose permease of Escherichia coli: Use of glycine-scanning mutagenesis to rescue mutant Glu325→Asp Biochemistry. 40: 769-776. PMID 11170394 DOI: 10.1021/bi002171m  1
2000 Zhang W, Kaback HR. Effect of the lipid phase transition on the lactose permease from Escherichia coli Biochemistry. 39: 14538-14542. PMID 11087408 DOI: 10.1021/bi001947g  1
2000 Zhao M, Kálai T, Hideg K, Altenbach C, Hubbell WL, Kaback HR. Binding of spin-labeled galactosides to the lactose permease of Escherichia coli. Biochemistry. 39: 11381-8. PMID 10985783 DOI: 10.1021/bi001075i  1
2000 Sahin-Tóth M, Karlin A, Kaback HR. Unraveling the mechanism of the lactose permease of Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 97: 10729-32. PMID 10984523 DOI: 10.1073/pnas.200351797  1
2000 Venkatesan P, Hu Y, Kaback HR. Site-directed sulfhydryl labeling of the lactose permease of Escherichia coli: Helix X Biochemistry. 39: 10656-10661. PMID 10978149 DOI: 10.1021/bi0004403  1
2000 Venkatesan P, Liu Z, Hu Y, Kaback HR. Site-directed sulfhydryl labeling of the lactose permease of Escherichia coli: N-ethylmaleimide-sensitive face of helix II Biochemistry. 39: 10649-10655. PMID 10978148 DOI: 10.1021/bi0004394  1
2000 Venkatesan P, Kwaw I, Hu Y, Kaback HR. Site-directed sulfhydryl labeling of the lactose permease of Escherichia coli: Helix VII Biochemistry. 39: 10641-10648. PMID 10978147 DOI: 10.1021/bi000438b  1
2000 Weinglass AB, Kaback HR. The central cytoplasmic loop of the major facilitator superfamily of transport proteins governs efficient membrane insertion Proceedings of the National Academy of Sciences of the United States of America. 97: 8938-8943. PMID 10880570 DOI: 10.1073/pnas.140224497  1
2000 Heymann JB, Pfeiffer M, Hildebrandt V, Kaback HR, Fotiadis D, Groot B, Engel A, Oesterhelt D, Müller DJ. Conformations of the rhodopsin third cytoplasmic loop grafted onto bacteriorhodopsin. Structure (London, England : 1993). 8: 643-53. PMID 10873864 DOI: 10.1016/S0969-2126(00)00151-9  1
2000 Sahin-Tóth M, Kaback HR. Functional conservation in the putative substrate binding site of the sucrose permease from Escherichia coli Biochemistry. 39: 6170-6175. PMID 10821691 DOI: 10.1021/bi000125g  1
2000 Sahin-Tóth M, Frillingos S, Lawrence MC, Kaback HR. The sucrose permease of Escherichia coli: functional significance of cysteine residues and properties of a cysteine-less transporter. Biochemistry. 39: 6164-9. PMID 10821690 DOI: 10.1021/bi000124o  1
2000 Wolin CD, Kaback HR. Thiol cross-linking of transmembrane domains IV and V in the lactose permease of Escherichia coli. Biochemistry. 39: 6130-5. PMID 10821686 DOI: 10.1021/bi0001269  1
2000 Sahin-Tóth M, Akhoon KM, Runner J, Kaback HR. Ligand recognition by the lactose permease of Escherichia coli: specificity and affinity are defined by distinct structural elements of galactopyranosides. Biochemistry. 39: 5097-103. PMID 10819976 DOI: 10.1021/bi0000263  1
2000 le Coutre J, Whitelegge JP, Gross A, Turk E, Wright EM, Kaback HR, Faull KF. Proteomics on full-length membrane proteins using mass spectrometry. Biochemistry. 39: 4237-42. PMID 10757971 DOI: 10.1021/bi000150m  1
2000 Kwaw I, Jianzhong S, Kaback HR. Thiol cross-linking of cytoplasmic loops in the lactose permease of Escherichia coli Biochemistry. 39: 3134-3140. PMID 10715135 DOI: 10.1021/bi992509g  1
1999 Zhao M, Zen KC, Hernandez-Borrell J, Altenbach C, Hubbell WL, Kaback HR. Nitroxide scanning electron paramagnetic resonance of helices IV and V and the intervening loop in the lactose permease of Escherichia coli. Biochemistry. 38: 15970-7. PMID 10625464 DOI: 10.1021/bi991754x  1
1999 Wang Q, Kaback HR. Location of helix III in the lactose permease of Escherichia coli as determined by site-directed thiol cross-linking Biochemistry. 38: 16777-16782. PMID 10606509 DOI: 10.1021/bi991853a  1
1999 Weinglass AB, Kaback HR. Conformational flexibility at the substrate binding site in the lactose permease of Escherichia coli Proceedings of the National Academy of Sciences of the United States of America. 96: 11178-11182. PMID 10500150 DOI: 10.1073/pnas.96.20.11178  1
1999 Whitelegge JP, le Coutre J, Lee JC, Engel CK, Privé GG, Faull KF, Kaback HR. Toward the bilayer proteome, electrospray ionization-mass spectrometry of large, intact transmembrane proteins. Proceedings of the National Academy of Sciences of the United States of America. 96: 10695-8. PMID 10485888 DOI: 10.1073/pnas.96.19.10695  1
1999 Wang Q, Kaback HR. Proximity relationships between helices I and XI or XII in the lactose permease of Escherichia coli determined by site-directed thiol cross-linking Journal of Molecular Biology. 291: 683-692. PMID 10448046 DOI: 10.1006/jmbi.1999.2948  1
1999 Wolin CD, Kaback HR. Estimating loop-helix interfaces in a polytopic membrane protein by deletion analysis. Biochemistry. 38: 8590-7. PMID 10387107 DOI: 10.1021/bi990650j  1
1999 Zhao M, Zen KC, Hubbell WL, Kaback HR. Proximity between Glu126 and Arg144 in the lactose permease of Escherichia coli. Biochemistry. 38: 7407-12. PMID 10360937 DOI: 10.1021/bi9906524  1
1999 Zhuang J, Privé GG, Werner GE, Ringler P, Kaback HR, Engel A. Two-dimensional crystallization of Escherichia coli lactose permease Journal of Structural Biology. 125: 63-75. PMID 10196117 DOI: 10.1006/jsbi.1998.4059  1
1999 Sondej M, Sun J, Seok YJ, Kaback HR, Peterkofsky A. Deduction of consensus binding sequences on proteins that bind IIa(Glc) of the phosphoenolpyruvate:sugar phosphotransferase system by cysteine scanning mutagenesis of Escherichia coli lactose permease Proceedings of the National Academy of Sciences of the United States of America. 96: 3525-3530. PMID 10097069 DOI: 10.1073/pnas.96.7.3525  1
1999 Wang Q, Kaback HR. Helix packing in the lactose permease of Escherichia coli determined by site-directed thiol cross-linking: Helix I is close to helices V and XI Biochemistry. 38: 3120-3126. PMID 10074366 DOI: 10.1021/bi982507g  1
1999 Sun J, Voss J, Hubbell WL, Kaback HR. Proximity between periplasmic loops in the lactose permease of Escherichia coli as determined by site-directed spin labeling. Biochemistry. 38: 3100-5. PMID 10074363 DOI: 10.1021/bi982360t  1
1999 Wu J, Hardy D, Kaback HR. Tertiary contacts of helix V in the lactose permease determined by site- directed chemical cross-linking in situ Biochemistry. 38: 2320-2325. PMID 10029525 DOI: 10.1021/bi982288z  1
1999 Wu J, Hardy D, Kaback HR. Site-directed chemical cross-linking demonstrates that helix IV is close to helices VII and XI in the lactose permease Biochemistry. 38: 1715-1720. PMID 10026249 DOI: 10.1021/bi982342b  1
1999 Sahin-Tóth M, le Coutre J, Kharabi D, le Maire G, Lee JC, Kaback HR. Characterization of Glu126 and Arg144, two residues that are indispensable for substrate binding in the lactose permease of Escherichia coli. Biochemistry. 38: 813-9. PMID 9888822 DOI: 10.1021/bi982200h  1
1999 Kaback HR, Wu J. What to do while awaiting crystals of a membrane transport protein and thereafter Accounts of Chemical Research. 32: 805-813. DOI: 10.1021/ar970256i  1
1999 Zhao M, Zen KC, Hubbell WL, Kaback HR. Proximity between Glu126 and Arg144 in the lactose permease of Escherichia coli Biochemistry. 38.  1
1998 Kaback HR. Structure/function studies on the lactose permease of Escherichia coli Acta Physiologica Scandinavica, Supplement. 163: 21-33. PMID 9789544  1
1998 Frillingos S, Sahin-Tóth M, Wu J, Kaback HR. Cys-scanning mutagenesis: A novel approach to structure-function relationships in polytopic membrane proteins Faseb Journal. 12: 1281-1299. PMID 9761772 DOI: 10.1096/fasebj.12.13.1281  1
1998 Wu J, Hardy D, Kaback HR. Transmembrane helix tilting and ligand-induced conformational changes in the lactose permease determined by site-directed chemical crosslinking in situ Journal of Molecular Biology. 282: 959-967. PMID 9753547 DOI: 10.1006/jmbi.1998.2065  1
1998 Venkatesan P, Kaback HR. The substrate-binding site in the lactose permease of Escherichia coli Proceedings of the National Academy of Sciences of the United States of America. 95: 9802-9807. PMID 9707556 DOI: 10.1073/pnas.95.17.9802  1
1998 Voss J, Sun J, Venkatesan P, Kaback HR. Sulfhydryl oxidation of mutants with cysteine in place of acidic residues in the lactose permease Biochemistry. 37: 8191-8196. PMID 9609715 DOI: 10.1021/bi9802667  1
1998 Sun J, Kemp CR, Kaback HR. Ligand-induced changes in periplasmic loops in the lactose permease of Escherichia coli. Biochemistry. 37: 8020-6. PMID 9609695 DOI: 10.1021/bi973192s  1
1998 le Coutre J, Kaback HR, Patel CK, Heginbotham L, Miller C. Fourier transform infrared spectroscopy reveals a rigid alpha-helical assembly for the tetrameric Streptomyces lividans K+ channel. Proceedings of the National Academy of Sciences of the United States of America. 95: 6114-7. PMID 9600926 DOI: 10.1073/pnas.95.11.6114  1
1998 He MM, Kaback HR. In vitro folding of a membrane protein: Effect of denaturation and renaturation on substrate binding by the lactose permease of Escherichia coli Molecular Membrane Biology. 15: 15-20. PMID 9595550  1
1998 Wang Q, Voss J, Hubbell WL, Kaback HR. Proximity of helices VIII (Ala273) and IX (Met299) in the lactose permease of Escherichia coli. Biochemistry. 37: 4910-5. PMID 9538009 DOI: 10.1021/bi972990f  1
1998 Voss J, Hubbell WL, Kaback HR. Helix packing in the lactose permease determined by metal-nitroxide interaction Biochemistry. 37: 211-216. PMID 9425041 DOI: 10.1021/bi972152l  1
1997 Kaback HR, Wu J. From membrane to molecule to the third amino acid from the left with a membrane transport protein Quarterly Reviews of Biophysics. 30: 333-364. PMID 9634651 DOI: 10.1017/S0033583597003387  1
1997 Frillingos S, Gonzalez A, Kaback HR. Cysteine-scanning mutagenesis of helix IV and the adjoining loops in the lactose permease of Escherichia coli: Glu126 and Arg144 are essential Biochemistry. 36: 14284-14290. PMID 9400367 DOI: 10.1021/bi972314d  1
1997 Voss J, Hubbell WL, Hernandez-Borrell J, Kaback HR. Site-directed spin-labeling of transmembrane domain VII and the 4B1 antibody epitope in the lactose permease of Escherichia coli Biochemistry. 36: 15055-15061. PMID 9398232 DOI: 10.1021/bi971726j  1
1997 Seok YJ, Sun J, Kaback HR, Peterkofsky A. Topology of allosteric regulation of lactose permease Proceedings of the National Academy of Sciences of the United States of America. 94: 13515-13519. PMID 9391057 DOI: 10.1073/pnas.94.25.13515  1
1997 Wang Q, Matsushita K, De Foresta B, Le Maire M, Kaback HR. Ligand-induced movement of helix X in the lactose permease from Escherichia coli: A fluorescence quenching study Biochemistry. 36: 14120-14127. PMID 9369484 DOI: 10.1021/bi9716433  1
1997 Braun P, Persson B, Kaback HR, Von Heijne G. Alanine insertion scanning mutagenesis of lactose permease transmembrane helices Journal of Biological Chemistry. 272: 29566-29571. PMID 9368019 DOI: 10.1074/jbc.272.47.29566  1
1997 He MM, Kaback HR. Interaction between residues Glu269 (helix VIII) and His322 (helix X) of the lactose permease of Escherichia coli is essential for substrate binding Biochemistry. 36: 13688-13692. PMID 9354639 DOI: 10.1021/bi9715324  1
1997 He MM, Voss J, Hubbell WL, Kaback HR. Arginine 302 (helix IX) in the lactose permease of Escherichia coli is in close proximity to glutamate 269 (helix VIII) as well as glutamate 325 (helix X) Biochemistry. 36: 13682-13687. PMID 9354638 DOI: 10.1021/bi971531b  1
1997 Sun J, Kaback HR. Proximity of periplasmic loops in the lactose permease of Escherichia coli determined by site-directed cross-linking Biochemistry. 36: 11959-11965. PMID 9305990 DOI: 10.1021/bi971172k  1
1997 le Coutre J, Narasimhan LR, Patel CK, Kaback HR. The lipid bilayer determines helical tilt angle and function in lactose permease of Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 94: 10167-71. PMID 9294181 DOI: 10.1073/pnas.94.19.10167  1
1997 Kaback HR, Voss J, Wu J. Helix packing in polytopic membrane proteins: The lactose permease of Escherichia coli Current Opinion in Structural Biology. 7: 537-542. PMID 9266176 DOI: 10.1016/S0959-440X(97)80119-4  1
1997 Wu J, Kaback HR. Helix proximity and ligand-induced conformational changes in the lactose permease of Escherichia coli determined by site-directed chemical crosslinking Journal of Molecular Biology. 270: 285-293. PMID 9236129 DOI: 10.1006/jmbi.1997.1099  1
1997 Sun J, Frillingos S, Kaback HR. Binding of monoclonal antibody 4B1 to homologs of the lactose permease of Escherichia coli Protein Science. 6: 1503-1510. PMID 9232651  1
1997 Frillingos S, Wu J, Venkatesan P, Kaback HR. Binding of ligand or monoclonal antibody 4B1 induces discrete structural changes in the lactose permease of Escherichia coli Biochemistry. 36: 6408-6414. PMID 9174357 DOI: 10.1021/bi970233b  1
1997 Kaback HR. A molecular mechanism for energy coupling in a membrane transport protein, the lactose permease of Escherichia coli Proceedings of the National Academy of Sciences of the United States of America. 94: 5539-5543. PMID 9159108 DOI: 10.1073/pnas.94.11.5539  1
1997 Frillingos S, Kaback HR. The role of helix VII in the lactose permease of Escherichia coli: II. Site-directed sulfhydryl modification Protein Science. 6: 438-443. PMID 9041647  1
1997 Frillingos S, Ujwal ML, Sun J, Kaback HR. The role of helix VIII in the lactose permease of Escherichia coli: I. Cys-scanning mutagenesis Protein Science. 6: 431-437. PMID 9041646  1
1997 Merickel A, Kaback HR, Edwards RH. Charged residues in transmembrane domains II and XI of a vesicular monoamine transporter form a charge pair that promotes high affinity substrate recognition. The Journal of Biological Chemistry. 272: 5403-8. PMID 9038139 DOI: 10.1074/jbc.272.9.5403  1
1997 Sun J, Li J, Carrasco N, Kaback HR. The last two cytoplasmic loops in the lactose permease of Escherichia coli comprise a discontinuous epitope for a monoclonal antibody Biochemistry. 36: 274-280. PMID 8993344 DOI: 10.1021/bi962292f  1
1997 Frillingos S, Sun J, Gonzalez A, Kaback HR. Cysteine-scanning mutagenesis of helix II and flanking hydrophilic domains in the lactose permease of Escherichia coli Biochemistry. 36: 269-273. PMID 8993343 DOI: 10.1021/bi9618629  1
1996 Wu J, Kaback HR. A general method for determining helix packing in membrane proteins in situ: Helices I and II are close to helix VII in the lactose permease of Escherichia coli Proceedings of the National Academy of Sciences of the United States of America. 93: 14498-14502. PMID 8962080 DOI: 10.1073/pnas.93.25.14498  1
1996 Wu J, Voss J, Hubbell WL, Kaback HR. Site-directed spin labeling and chemical crosslinking demonstrate that helix V is close to helices VII and VIII in the lactose permease of Escherichia coli Proceedings of the National Academy of Sciences of the United States of America. 93: 10123-10127. PMID 8816762 DOI: 10.1073/pnas.93.19.10123  1
1996 Privé GG, Kaback HR. Engineering the lac permease for purification and crystallization Journal of Bioenergetics and Biomembranes. 28: 29-34. PMID 8786234  1
1996 Pourcher T, Bibi E, Kaback HR, Leblanc G. Membrane topology of the melibiose permease of Escherichia coli studied by melB-phoA fusion analysis Biochemistry. 35: 4161-4168. PMID 8672452 DOI: 10.1021/bi9527496  1
1996 Frillingos S, Kaback HR. Probing the conformation of the lactose permease of Escherichia coli by in situ site-directed sulfhydryl modification Biochemistry. 35: 3950-3956. PMID 8672426 DOI: 10.1021/bi952601m  1
1996 Bogdanov M, Sun J, Kaback HR, Dowhan W. A phospholipid acts as a chaperone in assembly of a membrane transport protein Journal of Biological Chemistry. 271: 11615-11618. PMID 8662750 DOI: 10.1074/jbc.271.20.11615  1
1996 Sahin-Tóth M, Kaback HR, Friedlander M. Association between the amino- and carboxyl-terminal halves of lactose permease is specific and mediated by multiple transmembrane domains Biochemistry. 35: 2016-2021. PMID 8639686 DOI: 10.1021/bi952496g  1
1996 Frillingos S, Kaback HR. Cysteine-scanning mutagenesis of helix VI and the flanking hydrophilic domains in the lactose permease of Escherichia coli Biochemistry. 35: 5333-5338. PMID 8611521 DOI: 10.1021/bi953068d  1
1996 Wu J, Sun J, Kaback HR. Purification and functional characterization of the C-terminal half of the lactose permease of Escherichia coli Biochemistry. 35: 5213-5219. PMID 8611506 DOI: 10.1021/bi960064f  1
1996 Sun J, Wu J, Carrasco N, Kaback HR. Identification of the epitope for monoclonal antibody 4B1 which uncouples lactose and proton translocation in the lactose permease of Escherichia coli Biochemistry. 35: 990-998. PMID 8547282 DOI: 10.1021/bi952166w  1
1996 Kaback HR. Chapter 10 The lactose permease of Escherichia coli: Past, present and future Handbook of Biological Physics. 2: 203-227. DOI: 10.1016/S1383-8121(96)80051-0  1
1996 Konings WN, Kaback HR, Lolkema JS. Preface to volume 2 Transport processes in eukaryotic and prokaryotic organisms Handbook of Biological Physics. 2: ix-x. DOI: 10.1016/S1383-8121(96)80040-6  1
1996 Wu J, Voss W, Hubbell L, Kaback HR. Helix packing of lactose permease as studied by site-directed electron paramegnetic resonance spec t ros copy and chemical crosslinking. I Faseb Journal. 10.  1
1995 Voss J, Hubbell WL, Kaback HR. Distance determination in proteins using designed metal ion binding sites and site-directed spin labeling: Application to the lactose permease of Escherichia coli Proceedings of the National Academy of Sciences of the United States of America. 92: 12300-12303. PMID 8618889 DOI: 10.1073/pnas.92.26.12300  1
1995 Voss J, Salwiński Ł, Kaback HR, Hubbell WL. A method for distance determination in proteins using a designed metal ion binding site and site-directed spin labeling: Evaluation with T4 lysozyme Proceedings of the National Academy of Sciences of the United States of America. 92: 12295-12299. PMID 8618888 DOI: 10.1073/pnas.92.26.12295  1
1995 Weitzman C, Consler TG, Kaback HR. Fluorescence of native single-Trp mutants in the lactose permease from Escherichia coli: Structural properties and evidence for a substrate-induced conformational change Protein Science. 4: 2310-2318. PMID 8563627  1
1995 Zen KH, Consler TG, Kaback HR. Insertion of the polytopic membrane protein lactose permease occurs by multiple mechanisms Biochemistry. 34: 3430-3437. PMID 7880837  1
1995 Jung K, Voss J, He M, Hubbell WL, Kaback HR. Engineering a metal binding site within a polytopic membrane protein, the lactose permease of Escherichia coli Biochemistry®. 34: 6272-6277. PMID 7756253  1
1995 Weitzman C, Kaback HR. Cysteine scanning mutagenesis of helix V in the lactose permease of Escherichia coli Biochemistry. 34: 9374-9379. PMID 7626607 DOI: 10.1021/bi00029a013  1
1995 Ujwal ML, Jung H, Bibi E, Manoil C, Altenbach C, Hubbell WL, Kaback HR. Membrane topology of helices VII and XI in the lactose permease of Escherichia coli studied by lacY-phoA fusion analysis and site-directed spectroscopy Biochemistry. 34: 14909-14917. PMID 7578103  1
1995 Wu J, Perrin DM, Sigman DS, Kaback HR. Helix packing of lactose permease in Escherichia coli studied by site-directed chemical cleavage Proceedings of the National Academy of Sciences of the United States of America. 92: 9186-9190. PMID 7568098  1
1995 Sahin-Tóth M, Frillingos S, Lengeler JW, Kaback HR. Active transport by the cscB permease in Escherichia coli K-12 Biochemical and Biophysical Research Communications. 208: 1116-1123. PMID 7535526 DOI: 10.1006/bbrc.1995.1449  1
1995 Kaback HR, Jung K, Jung H, Wu J, Privé GG, Zen K. Helix packing in the C-terminal half of lactose permease Advances in Cellular and Molecular Biology of Membranes and Organelles. 4: 129-144. DOI: 10.1016/S1874-5172(06)80010-6  1
1994 Privé GG, Verner GE, Weitzman C, Zen KH, Eisenberg D, Kaback HR. Fusion proteins as tools for crystallization: the lactose permease from Escherichia coli. Acta Crystallographica. Section D, Biological Crystallography. 50: 375-9. PMID 15299388 DOI: 10.1107/S0907444993014301  0.88
1994 Sahin-Tóth M, Lawrence MC, Kaback HR. Properties of permease dimer, a fusion protein containing two lactose permease molecules from Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 91: 5421-5. PMID 8202501 DOI: 10.1073/pnas.91.12.5421  1
1994 Zen KH, McKenna E, Bibi E, Hardy D, Kaback HR. Expression of lactose permease in contiguous fragments as a probe for membrane-spanning domains Biochemistry. 33: 8198-8206. PMID 8031753 DOI: 10.1021/bi00193a005  1
1994 Sahin-Toth M, Persson B, Schwieger J, Cohan P, Kaback HR. Cysteine scanning mutagenesis of the N-terminal 32 amino acid residues in the lactose permease of Escherichia coli Protein Science. 3: 240-247. PMID 8003960  1
1994 Jung H, Jung K, Kaback HR. A conformational change in the lactose permease of Escherichia coli is induced by ligand binding or membrane potential Protein Science. 3: 1052-1057. PMID 7920250  1
1994 Wu J, Kaback HR. Cysteine 148 in the lactose permease of Escherichia coli is a component of a substrate binding site. 2. Site-directed fluorescence studies Biochemistry. 33: 12166-12171. PMID 7918438 DOI: 10.1021/bi00206a020  1
1994 Jung H, Jung K, Kaback HR. Cysteine 148 in the lactose permease of Escherichia coli is a component of a substrate binding site. 1. Site-directed mutagenesis studies Biochemistry. 33: 12160-12165. PMID 7918437 DOI: 10.1021/bi00206a019  1
1994 Ujwal ML, Sahin-Tóth M, Persson B, Kaback HR. Role of glutamate-269 in the lactose permease of escherichia coli Molecular Membrane Biology. 11: 9-16. PMID 7912610 DOI: 10.3109/09687689409161024  1
1994 Kaback HR, Frillingos S, Jung H, Jung K, Prive GG, Ujwal ML, Weitzman C, Wu Jianhua, Zen K. The lactose permease meets Frankenstein Journal of Experimental Biology. 196: 183-195. PMID 7823021  1
1994 Sahin-Toth M, Frillingos S, Bibi E, Gonzalez A, Kaback HR. The role of transmembrane domain III in the lactose permease of Escherichia coli Protein Science. 3: 2302-2310. PMID 7756986  1
1994 Wu J, Frillingos S, Voss J, Kaback HR. Ligand-induced conformational changes in the lactose permease of Escherichia coli: Evidence for two binding sites Protein Science. 3: 2294-2301. PMID 7756985 DOI: 10.1002/pro.5560031214  1
1994 Frillingos S, Sahin-Tóth M, Persson B, Kaback HR. Cysteine-scanning mutagenesis of putative helix VII in the lactose permease of Escherichia coli Biochemistry. 33: 8074-8081.  1
1993 Consler TG, Persson BL, Jung H, Zen KH, Jung K, Privé GG, Verner GE, Kaback HR. Properties and purification of an active biotinylated lactose permease from Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 90: 6934-8. PMID 8346199  0.88
1993 Sahin-Toth M, Kaback HR. Cysteine scanning mutagenesis of putative transmembrane helices IX and X in the lactose permease of Escherichia coli Protein Science. 2: 1024-1033. PMID 8318887 DOI: 10.1002/pro.5560020615  1
1993 Dunten RL, Sahin-Toth M, Kaback HR. Cysteine scanning mutagenesis of putative helix XI in the lactose permease of Escherichia coli Biochemistry. 32: 12644-12650. PMID 8251482 DOI: 10.1021/bi00210a012  1
1993 Jung K, Jung H, Wu J, Privé GG, Kaback HR. Use of site-directed fluorescence labeling to study proximity relationships in the lactose permease of Escherichia coli. Biochemistry. 32: 12273-8. PMID 8241112  0.88
1993 Kaback HR, Jung K, Jung H, Wu J, Privé GG, Zen K. What's new with lactose permease. Journal of Bioenergetics and Biomembranes. 25: 627-36. PMID 8144491  0.88
1993 Bibi E, Gros P, Kaback HR. Functional expression of mouse mdr1 in Escherichia coli Proceedings of the National Academy of Sciences of the United States of America. 90: 9209-9213. PMID 8105473  1
1992 Bibi E, Stearns SM, Kaback HR. The N-terminal 22 amino acid residues in the lactose permease of Escherichia coli are not obligatory for membrane insertion or transport activity Proceedings of the National Academy of Sciences of the United States of America. 89: 3180-3184. PMID 1565610  1
1992 Bibi E, Kaback HR. Functional complementation of internal deletion mutants in the lactose permease of Escherichia coli Proceedings of the National Academy of Sciences of the United States of America. 89: 1524-1528. PMID 1542643  1
1992 Sahin-Toth M, Dunten RL, Gonzalez A, Kaback HR. Functional interactions between putative intramembrane charged residues in the lactose permease of Escherichia coli Proceedings of the National Academy of Sciences of the United States of America. 89: 10547-10551. PMID 1438245 DOI: 10.1073/pnas.89.21.10547  1
1992 Persson B, Roepe PD, Patel L, Lee J, Kaback HR. Site-directed mutagenesis of lysine 319 in the lactose permease of Escherichia coli Biochemistry. 31: 8892-8897. PMID 1390676  1
1992 Gros P, Talbot F, Tang-Wai D, Bibi E, Kaback HR. Lipophilic cations: A group of model substrates for the multidrug- resistance transporter Biochemistry. 31: 1992-1998. PMID 1371401 DOI: 10.1021/bi00122a014  1
1991 McKenna E, Hardy D, Pastore JC, Kaback HR. Sequential truncation of the lactose permease over a three-amino acid sequence near the carboxyl terminus leads to progressive loss of activity and stability Proceedings of the National Academy of Sciences of the United States of America. 88: 2969-2973. PMID 2014218 DOI: 10.1073/pnas.88.8.2969  1
1991 Bibi E, Verner G, Chang CY, Kaback HR. Organization and stability of a polytopic membrane protein: Deletion analysis of the lactose permease of Escherichia coli Proceedings of the National Academy of Sciences of the United States of America. 88: 7271-7275. PMID 1871132  1
1990 Menezes ME, Roepe PD, Kaback HR. Design of a membrane transport protein for fluorescence spectroscopy Proceedings of the National Academy of Sciences of the United States of America. 87: 1638-1642. PMID 2408040  1
1990 Bibi E, Kaback HR. In vivo expression of the lacY gene in two segments leads to functional lac permease Proceedings of the National Academy of Sciences of the United States of America. 87: 4325-4329. PMID 2190220 DOI: 10.1073/pnas.87.11.4325  1
1990 Roepe PD, Kaback HR. Isolation and functional reconstitution of soluble melibiose permease from Escherichia coli Biochemistry. 29: 2572-2577. PMID 2185831  1
1990 Roepe PD, Consler TG, Menezes ME, Kaback HR. The lac permease of Escherichia coli: site-directed mutagenesis studies on the mechanism of β-galactoside/H+ symport Research in Microbiology. 141: 290-308. PMID 2177909 DOI: 10.1016/0923-2508(90)90003-9  1
1989 Roepe PD, Kaback HR. Characterization and functional reconstitution of a soluble form of the hydrophobic membrane protein lac permease from Escherichia coli Proceedings of the National Academy of Sciences of the United States of America. 86: 6087-6091. PMID 2668955  1
1989 Roepe PD, Zbar RIS, Sarkar K, Kaback HR. A five-residue sequence near the carboxyl terminus of the polytopic membrane protein lac permease is required for stability within the membrane Proceedings of the National Academy of Sciences of the United States of America. 86: 3992-3996. PMID 2657733  1
1989 Carrasco N, Püttner IB, Antes LM, Lee JA, Larigan JD, Lolkema JS, Roepe PD, Kaback HR. Characterization of site-directed mutants in the lac permease of Escherichia coli. 2. Glutamate-325 replacements Biochemistry. 28: 2533-2539. PMID 2567181  1
1987 Menick DR, Lee JA, Brooker RJ, Wilson TH, Kaback HR. Role of cysteine residues in the lac permease of Escherichia coli. Biochemistry. 26: 1132-6. PMID 3552042 DOI: 10.1021/bi00378a022  1
1985 Hamamoto T, Carrasco N, Matsushita K, Kaback HR, Montal M. Direct measurement of the electrogenic activity of o-type cytochrome oxidase from Escherichia coli reconstituted into planar lipid bilayers. Proceedings of the National Academy of Sciences of the United States of America. 82: 2570-3. PMID 2986123 DOI: 10.1073/pnas.82.9.2570  1
1984 Matsushita K, Patel L, Kaback HR. Cytochrome o type oxidase from Escherichia coli. Characterization of the enzyme and mechanism of electrochemical proton gradient generation Biochemistry. 23: 4703-4714. PMID 6093862 DOI: 10.1021/bi00315a028  1
1983 Garcia ML, Viitanen P, Foster DL, Kaback HR. Mechanism of lactose translocation in proteoliposomes reconstituted with lac carrier protein purified from Escherichia coli. I. Effect of pH and imposed membrane potential on efflux, exchange, and counterflow Biochemistry. 22: 2524-2531. PMID 6344920 DOI: 10.1021/bi00279a033  1
1983 Viitanen P, Garcia ML, Foster DL, Kaczorowski GJ, Kaback HR. Mechanism of lactose translocation in proteoliposomes reconstituted with lac carrier protein purified from Escherichia coli. 2. Deuterium solvent isotope effects Biochemistry. 22: 2531-2536. PMID 6305403 DOI: 10.1021/bi00279a034  1
1983 Young JD, Unkeless JC, Kaback HR, Cohn ZA. Mouse macrophage Fc receptor for IgG gamma 2b/gamma 1 in artificial and plasma membrane vesicles functions as a ligand-dependent ionophore. Proceedings of the National Academy of Sciences of the United States of America. 80: 1636-40. PMID 6300861  1
1983 Young JD, Unkeless JC, Kaback HR, Cohn ZA. Macrophage membrane potential changes associated with gamma 2b/gamma 1 Fc receptor-ligand binding. Proceedings of the National Academy of Sciences of the United States of America. 80: 1357-61. PMID 6219390  1
1982 Santos E, Kung HF, Young IG, Kaback HR. In vitro synthesis of the membrane-bound D-lactate dehydrogenase of Escherichia coli Biochemistry. 21: 2085-2091. PMID 7046793 DOI: 10.1021/bi00538a016  1
1982 Patel L, Garcia ML, Kaback HR. Direct measurement of lactose/proton symport in Escherichia coli membrane vesicles: Further evidence for the involvement of histidine residue(s) Biochemistry. 21: 5805-5810. PMID 6295442 DOI: 10.1021/bi00266a013  1
1982 Foster DL, Garcia ML, Newman MJ, Patel L, Kaback HR. Lactose-proton symport by purified lac carrier protein Biochemistry. 21: 5634-5638. PMID 6293552 DOI: 10.1021/bi00265a038  1
1981 Guffanti AA, Cohn DE, Kaback HR, Krulwich TA. Relationship between the Na+/H+ antiporter and Na+/substrate symport in Bacillus alcalophilus Proceedings of the National Academy of Sciences of the United States of America. 78: 1481-1484. PMID 6262805 DOI: 10.1073/pnas.78.3.1481  1
1980 Friedberg I, Kaback HR. Electrochemical proton gradient in Micrococcus lysodeikticus cells and membrane vesicles Journal of Bacteriology. 142: 651-658. PMID 7380805 DOI: 10.1128/jb.142.2.651-658.1980  1
1980 Felle H, Porter JS, Slayman CL, Kaback HR. Quantitative measurements of membrane potential in Escherichia coli. Biochemistry. 19: 3585-90. PMID 6996707 DOI: 10.1021/bi00556a026  1
1979 Padan E, Schuldiner S, Kaback HR. Reconstitution of LAC carrier function in cholate-extracted membranes from Escherichia coli. Biochemical and Biophysical Research Communications. 91: 854-61. PMID 393263 DOI: 10.1016/0006-291X(79)91958-2  1
1979 Padan E, Patel L, Kaback HR. Effect of diethylpyrocarbonate on lactose/proton symport in Escherichia coli membrane vesicles Proceedings of the National Academy of Sciences of the United States of America. 76: 6221-6225. PMID 392515 DOI: 10.1073/pnas.76.12.6221  1
1979 Lichtshtein D, Dunlop K, Kaback HR, Blume AJ. Mechanism of monensin-induced hyperpolarization of neuroblastoma-glioma hybrid NG108-15. Proceedings of the National Academy of Sciences of the United States of America. 76: 2580-4. PMID 288048 DOI: 10.1073/pnas.76.6.2580  1
1979 Ramos S, Schuldiner S, Kaback HR. [74] The use of flow dialysis for determinations of ΔpH and active transport Methods in Enzymology. 55: 680-688. DOI: 10.1016/0076-6879(79)55076-9  1
1978 Kaback HR, Patel L. The role of functional sulfhydryl groups in active transport in Escherichia coli membrane vesicles Biochemistry. 17: 1640-1646. PMID 350273 DOI: 10.1021/bi00602a010  1
1977 Schuldiner S, Kaback HR. Fluorescent galactosides as probes for the lac carrier protein. Biochimica Et Biophysica Acta. 472: 399-418. PMID 334263 DOI: 10.1016/0304-4157(77)90004-1  1
1977 Schuldiner S, Weil R, Robertson DE, Kaback HR. Microenvironment of the binding site in the lac carrier protein. Proceedings of the National Academy of Sciences of the United States of America. 74: 1851-4. PMID 325557 DOI: 10.1073/pnas.74.5.1851  1
1976 Rudnick G, Schuldiner S, Kaback HR. Equilibrium between two forms of the lac carrier protein in energized and nonenergized membrane vesicles from Escherichia coli Biochemistry. 15: 5126-5131. PMID 791364 DOI: 10.1021/bi00668a028  1
1976 Schuldiner S, Weil R, Kaback HR. Energy-dependent binding of dansylgalactoside to the lac carrier protein: direct binding measurements. Proceedings of the National Academy of Sciences of the United States of America. 73: 109-12. PMID 174094 DOI: 10.1073/pnas.73.1.109  1
1976 Patel L, Kaback HR. The role of the carbodiimide-reactive component of the adenosine-5′-triphosphatase complex in the proton permeability of Escherichia coli membrane vesicles Biochemistry. 15: 2741-2746. PMID 132963 DOI: 10.1021/bi00658a005  1
1976 Ramos S, Schuldiner S, Kaback HR. The electrochemical gradient of protons and its relationship to active transport in Escherichia coli membrane vesicles. Proceedings of the National Academy of Sciences of the United States of America. 73: 1892-6. PMID 6961 DOI: 10.1073/pnas.73.6.1892  1
1975 Kaback HR, Rudnick G, Schuldiner S, Short SA. Active transport in isolated bacterial membrane vesicles: binding of beta-galactosides to the LAC carrier protein. Annals of the New York Academy of Sciences. 264: 350-7. PMID 769642 DOI: 10.1111/j.1749-6632.1975.tb31495.x  1
1975 Schuldiner S, Kaback HR. Membrane potential and active transport in membrane vesicles from Escherichia coli. Biochemistry. 14: 5451-61. PMID 172125 DOI: 10.1021/bi00696a011  1
1975 Patel L, Schuldiner S, Kaback HR. Reversible effects of chaotropic agents on the proton permeability of Escherichia coli membrane vesicles. Proceedings of the National Academy of Sciences of the United States of America. 72: 3387-91. PMID 171661 DOI: 10.1073/pnas.72.9.3387  1
1974 Short SA, Kaback HR, Kaczorowski G, Fisher J, Walsh CT, Silverstein SC. Determination of the absolute number of Escherichia coli membrane vesicles that catalyze active transport Proceedings of the National Academy of Sciences of the United States of America. 71: 5032-5036. PMID 4612538 DOI: 10.1073/pnas.71.12.5032  1
1974 Cox GS, Kaback HR, Weissbach H. Defective transport in S-adenosylmethionine synthetase mutants of Escherichia coli Archives of Biochemistry and Biophysics. 161: 610-620. PMID 4599317 DOI: 10.1016/0003-9861(74)90344-0  1
1973 Cox GS, Thomas E, Kaback HR, Weissbach H. Synthesis of cyclopropane fatty acids in isolated bacterial membranes Archives of Biochemistry and Biophysics. 158: 667-676. PMID 4592985 DOI: 10.1016/0003-9861(73)90559-6  1
1972 Hong JS, Kaback HR. Mutants of Salmonella typhimurium and Escherichia coli pleiotropically defective in active transport Proceedings of the National Academy of Sciences of the United States of America. 69: 3336-3340. PMID 4343963 DOI: 10.1073/pnas.69.11.3336  1
1966 Kaback HR, Stadtman ER. Proline uptake by an isolated cytoplasmic membrane preparation of Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 55: 920-7. PMID 5327072 DOI: 10.1073/pnas.55.4.920  1
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