Year |
Citation |
Score |
2015 |
Atigadda VR, Xia G, Deshpande A, Wu L, Kedishvili N, Smith CD, Krontiras H, Bland KI, Grubbs CJ, Brouillette WJ, Muccio DD. Conformationally Defined Rexinoids and Their Efficacy in the Prevention of Mammary Cancers. Journal of Medicinal Chemistry. 58: 7763-74. PMID 26331194 DOI: 10.1021/Acs.Jmedchem.5B00829 |
0.337 |
|
2014 |
Atigadda VR, Xia G, Desphande A, Boerma LJ, Lobo-Ruppert S, Grubbs CJ, Smith CD, Brouillette WJ, Muccio DD. Methyl substitution of a rexinoid agonist improves potency and reveals site of lipid toxicity. Journal of Medicinal Chemistry. 57: 5370-80. PMID 24801499 DOI: 10.1021/Jm5004792 |
0.349 |
|
2014 |
Desphande A, Xia G, Boerma LJ, Vines KK, Atigadda VR, Lobo-Ruppert S, Grubbs CJ, Moeinpour FL, Smith CD, Christov K, Brouillette WJ, Muccio DD. Methyl-substituted conformationally constrained rexinoid agonists for the retinoid X receptors demonstrate improved efficacy for cancer therapy and prevention. Bioorganic & Medicinal Chemistry. 22: 178-85. PMID 24359708 DOI: 10.1016/J.Bmc.2013.11.039 |
0.36 |
|
2014 |
Zha C, Brown GB, Brouillette WJ. A highly predictive 3D-QSAR model for binding to the voltage-gated sodium channel: design of potent new ligands. Bioorganic & Medicinal Chemistry. 22: 95-104. PMID 24332655 DOI: 10.1016/J.Bmc.2013.11.049 |
0.608 |
|
2012 |
Li Y, Silamkoti A, Kolavi G, Mou L, Gulati S, Air GM, Brouillette WJ. Pyrrolidinobenzoic acid inhibitors of influenza virus neuraminidase: the hydrophobic side chain influences type A subtype selectivity. Bioorganic & Medicinal Chemistry. 20: 4582-9. PMID 22677529 DOI: 10.1016/J.Bmc.2012.05.001 |
0.33 |
|
2012 |
Venkatramani L, Johnson ES, Kolavi G, Air GM, Brouillette WJ, Mooers BH. Crystal structure of a new benzoic acid inhibitor of influenza neuraminidase bound with a new tilt induced by overpacking subsite C6. Bmc Structural Biology. 12: 7. PMID 22559154 DOI: 10.1186/1472-6807-12-7 |
0.391 |
|
2009 |
Moro WB, Yang Z, Kane TA, Zhou Q, Harville S, Brouillette CG, Brouillette WJ. SAR studies for a new class of antibacterial NAD biosynthesis inhibitors. Journal of Combinatorial Chemistry. 11: 617-25. PMID 19408950 DOI: 10.1021/Cc9000357 |
0.325 |
|
2009 |
Moro WB, Yang Z, Kane TA, Brouillette CG, Brouillette WJ. Virtual screening to identify lead inhibitors for bacterial NAD synthetase (NADs). Bioorganic & Medicinal Chemistry Letters. 19: 2001-5. PMID 19249205 DOI: 10.1016/J.Bmcl.2009.02.034 |
0.324 |
|
2009 |
Muccio D, Lubet R, Atigadda V, Brouillette W, Grubbs C. Effects of methyl derivatives of the rexinoid UAB30 on methylnitrosourea (MNU) induced mammary cancers and on various indicators of toxicity. Cancer Research. 69: 1108. DOI: 10.1158/0008-5472.Sabcs-1108 |
0.307 |
|
2008 |
Lu S, Smith CD, Yang Z, Pruett PS, Nagy L, McCombs D, Delucas LJ, Brouillette WJ, Brouillette CG. Structure of nicotinic acid mononucleotide adenylyltransferase from Bacillus anthracis. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 64: 893-8. PMID 18931430 DOI: 10.1107/S1744309108029102 |
0.311 |
|
2007 |
Velu SE, Mou L, Luan CH, Yang ZW, DeLucas LJ, Brouillette CG, Brouillette WJ. Antibacterial nicotinamide adenine dinucleotide synthetase inhibitors: amide- and ether-linked tethered dimers with alpha-amino acid end groups. Journal of Medicinal Chemistry. 50: 2612-21. PMID 17489580 DOI: 10.1021/Jm061349L |
0.376 |
|
2005 |
Velu SE, Luan CH, Delucas LJ, Brouillette CG, Brouillette WJ. Tethered dimer inhibitors of NAD synthetase: parallel synthesis of an aryl-substituted SAR library. Journal of Combinatorial Chemistry. 7: 898-904. PMID 16283799 DOI: 10.1021/Cc050063J |
0.37 |
|
2005 |
Luo M, Jedrzejas MJ, Singh S, White CL, Brouillette WJ, Air GM, Laver WG. Benzoic acid inhibitors of influenza virus neuraminidase. Acta Crystallographica. Section D, Biological Crystallography. 51: 504-10. PMID 15299837 DOI: 10.1107/S0907444994011698 |
0.342 |
|
2004 |
Zha C, Brown GB, Brouillette WJ. Synthesis and structure-activity relationship studies for hydantoins and analogues as voltage-gated sodium channel ligands. Journal of Medicinal Chemistry. 47: 6519-28. PMID 15588087 DOI: 10.1021/Jm040077O |
0.637 |
|
2004 |
Lommer BS, Ali SM, Bajpai SN, Brouillette WJ, Air GM, Luo M. A benzoic acid inhibitor induces a novel conformational change in the active site of Influenza B virus neuraminidase. Acta Crystallographica. Section D, Biological Crystallography. 60: 1017-23. PMID 15159560 DOI: 10.1107/S0907444904006225 |
0.353 |
|
2004 |
Chand P, Babu YS, Bantia S, Rowland S, Dehghani A, Kotian PL, Hutchison TL, Ali S, Brouillette W, El-Kattan Y, Lin TH. Syntheses and neuraminidase inhibitory activity of multisubstituted cyclopentane amide derivatives. Journal of Medicinal Chemistry. 47: 1919-29. PMID 15055992 DOI: 10.1021/Jm0303406 |
0.4 |
|
2003 |
Atigadda VR, Vines KK, Grubbs CJ, Hill DL, Beenken SL, Bland KI, Brouillette WJ, Muccio DD. Conformationally defined retinoic acid analogues. 5. Large-scale synthesis and mammary cancer chemopreventive activity for (2E,4E,6Z,8E)-8-(3',4'-dihydro-1'(2'H)-naphthalen-1'-ylidene)-3,7-dimethyl-2,4,6-octatrienoic acid (9cUAB30). Journal of Medicinal Chemistry. 46: 3766-9. PMID 12904083 DOI: 10.1021/Jm030095Q |
0.335 |
|
2003 |
Velu SE, Cristofoli WA, Garcia GJ, Brouillette CG, Pierson MC, Luan CH, DeLucas LJ, Brouillette WJ. Tethered dimers as NAD synthetase inhibitors with antibacterial activity. Journal of Medicinal Chemistry. 46: 3371-81. PMID 12852767 DOI: 10.1021/Jm030003X |
0.326 |
|
2003 |
Brouillette WJ, Bajpai SN, Ali SM, Velu SE, Atigadda VR, Lommer BS, Finley JB, Luo M, Air GM. Pyrrolidinobenzoic acid inhibitors of influenza virus neuraminidase: modifications of essential pyrrolidinone ring substituents. Bioorganic & Medicinal Chemistry. 11: 2739-49. PMID 12788348 DOI: 10.1016/S0968-0896(03)00271-2 |
0.382 |
|
2001 |
Devedjiev Y, Symersky J, Singh R, Jedrzejas M, Brouillette C, Brouillette W, Muccio D, Chattopadhyay D, DeLucas L. Stabilization of active-site loops in NH3-dependent NAD+ synthetase from Bacillus subtilis. Acta Crystallographica. Section D, Biological Crystallography. 57: 806-12. PMID 11375500 DOI: 10.1107/S0907444901003523 |
0.308 |
|
1999 |
Atigadda VR, Brouillette WJ, Duarte F, Babu YS, Bantia S, Chand P, Chu N, Montgomery JA, Walsh DA, Sudbeck E, Finley J, Air GM, Luo M, Laver GW. Hydrophobic benzoic acids as inhibitors of influenza neuraminidase. Bioorganic & Medicinal Chemistry. 7: 2487-97. PMID 10632058 DOI: 10.1016/S0968-0896(99)00197-2 |
0.353 |
|
1999 |
Finley JB, Atigadda VR, Duarte F, Zhao JJ, Brouillette WJ, Air GM, Luo M. Novel aromatic inhibitors of influenza virus neuraminidase make selective interactions with conserved residues and water molecules in the active site. Journal of Molecular Biology. 293: 1107-19. PMID 10547289 DOI: 10.1006/Jmbi.1999.3180 |
0.354 |
|
1999 |
Hutchison TL, Saeed A, Wolkowicz PE, McMillin JB, Brouillette WJ. Stereoselective synthesis of a conformationally defined cyclohexyl carnitine analogue that binds CPT-1 with high affinity Bioorganic and Medicinal Chemistry. 7: 1505-1511. PMID 10482442 DOI: 10.1016/S0968-0896(99)00080-2 |
0.348 |
|
1999 |
Brouillette WJ, Atigadda VR, Luo M, Air GM, Babu YS, Bantia S. Design of benzoic acid inhibitors of influenza neuraminidase containing a cyclic substitution for the N-acetyl grouping. Bioorganic & Medicinal Chemistry Letters. 9: 1901-6. PMID 10450950 DOI: 10.1016/S0960-894X(99)00318-2 |
0.385 |
|
1999 |
Atigadda VR, Brouillette WJ, Duarte F, Ali SM, Babu YS, Bantia S, Chand P, Chu N, Montgomery JA, Walsh DA, Sudbeck EA, Finley J, Luo M, Air GM, Laver GW. Potent inhibition of influenza sialidase by a benzoic acid containing a 2-pyrrolidinone substituent. Journal of Medicinal Chemistry. 42: 2332-43. PMID 10395473 DOI: 10.1021/Jm980707K |
0.406 |
|
1999 |
Brown ML, Zha CC, Van Dyke CC, Brown GB, Brouillette WJ. Comparative molecular field analysis of hydantoin binding to the neuronal voltage-dependent sodium channel Journal of Medicinal Chemistry. 42: 1537-1545. PMID 10229624 DOI: 10.1021/jm980556l |
0.584 |
|
1998 |
Muccio DD, Brouillette WJ, Breitman TR, Taimi M, Emanuel PD, Zhang X, Chen G, Sani BP, Venepally P, Reddy L, Alam M, Simpson-Herren L, Hill DL. Conformationally defined retinoic acid analogues. 4. Potential new agents for acute promyelocytic and juvenile myelomonocytic leukemias. Journal of Medicinal Chemistry. 41: 1679-87. PMID 9572893 DOI: 10.1021/Jm970635H |
0.321 |
|
1997 |
Sudbeck EA, Jedrzejas MJ, Singh S, Brouillette WJ, Air GM, Laver WG, Babu YS, Bantia S, Chand P, Chu N, Montgomery JA, Walsh DA, Luo M. Guanidinobenzoic acid inhibitors of influenza virus neuraminidase. Journal of Molecular Biology. 267: 584-94. PMID 9126840 DOI: 10.1006/Jmbi.1996.0885 |
0.341 |
|
1997 |
Brown ML, Brown GB, Brouillette WJ. Effects of log P and phenyl ring conformation on the binding of 5- phenylhydantoins to the voltage-dependent sodium channel Journal of Medicinal Chemistry. 40: 602-607. PMID 9046351 DOI: 10.1021/Jm960692V |
0.35 |
|
1997 |
Lake CH, Alam M, Muccio DD, Brouillette WJ. A structural model for a new class of conformationally constrained retinoid: (2Z,4E)-4-[3′,4′-dihydro-1′(2′H)-naphthalene-1′-ylidene]-2-butenoic acid Journal of Chemical Crystallography. 27: 231-235. DOI: 10.1007/Bf02575960 |
0.329 |
|
1996 |
Muccio DD, Brouillette WJ, Alam M, Vaezi MF, Sani BP, Venepally P, Reddy L, Li E, Norris AW, Simpson-Herren L, Hill DL. Conformationally defined 6-s-trans-retinoic acid analogs. 3. Structure-activity relationships for nuclear receptor binding, transcriptional activity, and cancer chemopreventive activity. Journal of Medicinal Chemistry. 39: 3625-35. PMID 8809153 DOI: 10.1021/Jm9603126 |
0.319 |
|
1996 |
Sudbeck EA, Jedrzejas MJ, Singh S, Brouillette WJ, Air GM, Laver WG, Babu YS, Bantia S, Chand P, Chu N, Montgomery JA, Walsh DA, Luo M. Crystal structure of influenza virus neuraminidase with inhibitor 3,5-diguanidino-4-(N-acetylamino)benzoic acid Acta Crystallographica Section a Foundations of Crystallography. 52: C208-C208. DOI: 10.1107/S0108767396091052 |
0.308 |
|
1995 |
Jedrzejas MJ, Singh S, Brouillette WJ, Air GM, Luo M. A strategy for theoretical binding constant, Ki, calculations for neuraminidase aromatic inhibitors designed on the basis of the active site structure of influenza virus neuraminidase. Proteins. 23: 264-77. PMID 8592707 DOI: 10.1002/Prot.340230215 |
0.357 |
|
1995 |
Jedrzejas MJ, Singh S, Brouillette WJ, Laver WG, Air GM, Luo M. Structures of aromatic inhibitors of influenza virus neuraminidase. Biochemistry. 34: 3144-51. PMID 7880809 DOI: 10.1021/Bi00010A003 |
0.38 |
|
1995 |
Singh S, Jedrzejas MJ, Air GM, Luo M, Laver WG, Brouillette WJ. Structure-based inhibitors of influenza virus sialidase. A benzoic acid lead with novel interaction. Journal of Medicinal Chemistry. 38: 3217-25. PMID 7650674 DOI: 10.1021/Jm00017A005 |
0.397 |
|
1995 |
Robinson CY, Waterhous DV, Muccio DD, Brouillette WJ. Conformationally constrained precursors to retinoic acid analogs which stabilize the 9Z-configuration Bioorganic and Medicinal Chemistry Letters. 5: 953-958. DOI: 10.1016/0960-894X(95)00151-I |
0.322 |
|
1995 |
Vaezi MF, Brouillette WJ, Muccio DD. 13C NMR assignments of conforma-tionally defined 6-s-trans-retinoids Magnetic Resonance in Chemistry. 33: 497-499. DOI: 10.1002/Mrc.1260330616 |
0.314 |
|
1994 |
Brouillette WJ, Jestkov VP, Brown ML, Akhtar MS, DeLorey TM, Brown GB. Bicyclic hydantoins with a bridgehead nitrogen. Comparison of anticonvulsant activities with binding to the neuronal voltage-dependent sodium channel. Journal of Medicinal Chemistry. 37: 3289-93. PMID 7932556 DOI: 10.1021/Jm00046A013 |
0.404 |
|
1994 |
Saeed A, McMillin JB, Wolkowicz PE, Brouillette WJ. 3-Amino-5,5-dimethylhexanoic acid. Synthesis, resolution, and effects on carnitine acyltransferases. Journal of Medicinal Chemistry. 37: 3247-51. PMID 7932552 DOI: 10.1021/Jm00046A008 |
0.346 |
|
1994 |
Vaezi MF, Alam M, Sani BP, Rogers TS, Simpson-Herren L, Wille JJ, Hill DL, Doran TI, Brouillette WJ, Muccio DD. A conformationally defined 6-s-trans-retinoic acid isomer: synthesis, chemopreventive activity, and toxicity. Journal of Medicinal Chemistry. 37: 4499-507. PMID 7799400 DOI: 10.1021/Jm00052A009 |
0.341 |
|
1994 |
Brouillette WJ, Saeed A, Abuelyaman A, Hutchison TL, Wolkowicz PE, McMillin JB. Synthesis and enzymatic evaluation of conformationally defined carnitine analogs Journal of Organic Chemistry. 59: 4297-4303. DOI: 10.1021/Jo00094A049 |
0.357 |
|
1993 |
Saeed A, McMillin JB, Wolkowicz PE, Brouillette WJ. Carnitine acyltransferase enzymic catalysis requires a positive charge on the carnitine cofactor. Archives of Biochemistry and Biophysics. 305: 307-12. PMID 8373168 DOI: 10.1006/Abbi.1993.1427 |
0.303 |
|
1993 |
Brouillette WJ, Abuelyaman AS, Hosmer CA, Comber RN, Saeed A. Preparation of the racemate and enantiomers of 3-hydroxy-5,5-dimethylhexanoic acid Organic Preparations and Procedures International. 25: 243-246. DOI: 10.1080/00304949309457956 |
0.307 |
|
1990 |
Brouillette WJ, Brown GB, DeLorey TM, Liang G. Sodium channel binding and anticonvulsant activities of hydantoins containing conformationally constrained 5-phenyl substituents. Journal of Pharmaceutical Sciences. 79: 871-4. PMID 2177789 DOI: 10.1002/Jps.2600791005 |
0.379 |
|
1990 |
Akhtar MS, Brouillette WJ, Waterhous DV. Bicyclic imides with bridgehead nitrogen. Synthesis of an anti-Bredt bicyclic hydantoin Journal of Organic Chemistry. 55: 5222-5225. DOI: 10.1021/Jo00305A014 |
0.334 |
|
1989 |
Brouillette WJ, Grunewald GL, Brown GB, DeLorey TM, Akhtar MS, Liang G. Sodium channel binding and anticonvulsant activities for the enantiomers of a bicyclic 2,4-oxazolidinedione and monocyclic models. Journal of Medicinal Chemistry. 32: 1577-80. PMID 2544727 DOI: 10.1021/Jm00127A029 |
0.597 |
|
1988 |
Brouillette WJ, Brown GB, DeLorey TM, Shirali SS, Grunewald GL. Anticonvulsant activities of phenyl-substituted bicyclic 2,4-oxazolidinediones and monocyclic models. Comparison with binding to the neuronal voltage-dependent sodium channel. Journal of Medicinal Chemistry. 31: 2218-21. PMID 2846842 DOI: 10.1021/Jm00119A025 |
0.617 |
|
1987 |
Hope KD, Robinson CY, Vaezi MF, Brouillette WJ, Muccio DD. 13C NMR assignments of the isoprenoid chain carbons of retinoids from empirical chemical shift differences Magnetic Resonance in Chemistry. 25: 1040-1045. DOI: 10.1002/Mrc.1260251204 |
0.317 |
|
1984 |
Brouillette WJ, Grunewald GL. Synthesis and anticonvulsant activity of some substituted lactams and amides. Journal of Medicinal Chemistry. 27: 202-6. PMID 6694169 DOI: 10.1002/Chin.198431234 |
0.611 |
|
1984 |
Brouillette WJ, Friedrich JD, Muccio DD. Synthesis and carbon-13 NMR of an unusual tricyclic barbituric acid derivative Journal of Organic Chemistry. 49: 3227-3230. DOI: 10.1002/Chin.198506249 |
0.303 |
|
1980 |
Grunewald GL, Brouillette WJ, Finney JA. Synthesis of α-hydroxyamides via the cyanosilylation of aromatic ketones Tetrahedron Letters. 21: 1219-1220. DOI: 10.1016/S0040-4039(00)71375-X |
0.545 |
|
1979 |
Brouillette WJ, Smissman EE, Grunewald GL. N-acylcarbamates as intermediates in synthetic approaches to a bicyclic trimethylene-bridged 2,4-oxazolidinedione and hydantoin Journal of Organic Chemistry. 44: 839-843. DOI: 10.1021/Jo01319A039 |
0.627 |
|
1978 |
Grunewald GL, Brouillette WJ. An ethoxycarbonyl migration from an amide nitrogen to oxygen Journal of Organic Chemistry. 43: 1839-1841. DOI: 10.1021/Jo00403A058 |
0.502 |
|
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