| Year |
Citation |
Score |
| 2023 |
He A, Tian S, Kopper O, Horan DJ, Chen P, Bronson RT, Sheng R, Wu H, Sui L, Zhou K, Tao L, Wu Q, Huang Y, Shen Z, Han S, ... ... Dong M, et al. Targeted inhibition of Wnt signaling with a Clostridioides difficile toxin B fragment suppresses breast cancer tumor growth. Plos Biology. 21: e3002353. PMID 37943878 DOI: 10.1371/journal.pbio.3002353 |
0.435 |
|
| 2023 |
Liu Z, Lee PG, Krez N, Lam KH, Liu H, Przykopanski A, Chen P, Yao G, Zhang S, Tremblay JM, Perry K, Shoemaker CB, Rummel A, Dong M, Jin R. Structural basis for botulinum neurotoxin E recognition of synaptic vesicle protein 2. Nature Communications. 14: 2338. PMID 37095076 DOI: 10.1038/s41467-023-37860-8 |
0.315 |
|
| 2023 |
Fang Y, Chang AY, Verma D, Miyashita SI, Eszterhas S, Lee PG, Shen Y, Davis LR, Dong M, Bailey-Kellogg C, Griswold KE. Functional Deimmunization of Botulinum Neurotoxin Protease Domain via Computationally Driven Library Design and Ultrahigh-Throughput Screening. Acs Synthetic Biology. PMID 36623275 DOI: 10.1021/acssynbio.2c00426 |
0.328 |
|
| 2021 |
Thaker H, Zhang J, Miyashita SI, Cristofaro V, Park S, Hashemi-Gheinani A, Sullivan MP, Adam RM, Dong M. Knockin mouse models demonstrate differential contributions of synaptotagmin-1 and -2 as receptors for botulinum neurotoxins. Plos Pathogens. 17: e1009994. PMID 34662366 DOI: 10.1371/journal.ppat.1009994 |
0.31 |
|
| 2021 |
Chen P, Zeng J, Liu Z, Thaker H, Wang S, Tian S, Zhang J, Tao L, Gutierrez CB, Xing L, Gerhard R, Huang L, Dong M, Jin R. Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection. Nature Communications. 12: 3748. PMID 34145250 DOI: 10.1038/s41467-021-23878-3 |
0.498 |
|
| 2021 |
Chen P, Zeng J, Liu Z, Thaker H, Wang S, Tian S, Zhang J, Tao L, Gutierrez CB, Xing L, Gerhard R, Huang L, Dong M, Jin R. Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection. Nature Communications. 12: 3748. PMID 34145250 DOI: 10.1038/s41467-021-23878-3 |
0.498 |
|
| 2021 |
Zhou Y, Li D, Luo J, Chen A, Li X, Pan Z, Wan L, He L, Li D, Li Y, Dong M, Tao L. Sulfated glycosaminoglycans and low-density lipoprotein receptor mediate the cellular entry of Clostridium novyi alpha-toxin. Cell Research. PMID 33972749 DOI: 10.1038/s41422-021-00510-z |
0.437 |
|
| 2021 |
Pan Z, Zhang Y, Luo J, Li D, Zhou Y, He L, Yang Q, Dong M, Tao L. Functional analyses of epidemic Clostridioides difficile toxin B variants reveal their divergence in utilizing receptors and inducing pathology. Plos Pathogens. 17: e1009197. PMID 33507919 DOI: 10.1371/journal.ppat.1009197 |
0.514 |
|
| 2021 |
Miyashita SI, Zhang J, Zhang S, Shoemaker CB, Dong M. Delivery of single-domain antibodies into neurons using a chimeric toxin-based platform is therapeutic in mouse models of botulism. Science Translational Medicine. 13. PMID 33408184 DOI: 10.1126/scitranslmed.aaz4197 |
0.367 |
|
| 2020 |
Henkel D, Tatge H, Schöttelndreier D, Tao L, Dong M, Gerhard R. Receptor Binding Domains of TcdB from for Chondroitin Sulfate Proteoglycan-4 and Frizzled Proteins Are Functionally Independent and Additive. Toxins. 12. PMID 33255261 DOI: 10.3390/toxins12120736 |
0.551 |
|
| 2020 |
Tian S, Liu Y, Wu H, Liu H, Zeng J, Choi MY, Chen H, Gerhard R, Dong M. Genome-Wide CRISPR Screen Identifies Semaphorin 6A and 6B as Receptors for Paeniclostridium sordellii Toxin TcsL. Cell Host & Microbe. PMID 32302524 DOI: 10.1016/J.Chom.2020.03.007 |
0.379 |
|
| 2020 |
Yin L, Masuyer G, Zhang S, Zhang J, Miyashita SI, Burgin D, Lovelock L, Coker SF, Fu TM, Stenmark P, Dong M. Characterization of a membrane binding loop leads to engineering botulinum neurotoxin B with improved therapeutic efficacy. Plos Biology. 18: e3000618. PMID 32182233 DOI: 10.1371/Journal.Pbio.3000618 |
0.428 |
|
| 2019 |
Shen Y, Wu SY, Rancic V, Aggarwal A, Qian Y, Miyashita SI, Ballanyi K, Campbell RE, Dong M. Genetically encoded fluorescent indicators for imaging intracellular potassium ion concentration. Communications Biology. 2: 18. PMID 31924910 DOI: 10.1038/s42003-018-0269-2 |
0.406 |
|
| 2019 |
Martínez-Carranza M, Blasco P, Gustafsson R, Dong M, Berntsson RP, Widmalm G, Stenmark P. Synaptotagmin binding to botulinum neurotoxins. Biochemistry. PMID 31809018 DOI: 10.1021/Acs.Biochem.9B00554 |
0.4 |
|
| 2019 |
Dong M, Stenmark P. The Structure and Classification of Botulinum Toxins. Handbook of Experimental Pharmacology. PMID 31792680 DOI: 10.1007/164_2019_342 |
0.341 |
|
| 2019 |
Tian S, Wu Q, Zhou B, Choi MY, Ding B, Yang W, Dong M. Proteomic Analysis Identifies Membrane Proteins Dependent on the ER Membrane Protein Complex. Cell Reports. 28: 2517-2526.e5. PMID 31484065 DOI: 10.1016/J.Celrep.2019.08.006 |
0.347 |
|
| 2019 |
Tao L, Tian S, Zhang J, Liu Z, Robinson-McCarthy L, Miyashita SI, Breault DT, Gerhard R, Oottamasathien S, Whelan SPJ, Dong M. Sulfated glycosaminoglycans and low-density lipoprotein receptor contribute to Clostridium difficile toxin A entry into cells. Nature Microbiology. PMID 31160825 DOI: 10.1038/S41564-019-0464-Z |
0.585 |
|
| 2019 |
Košenina S, Masuyer G, Zhang S, Dong M, Stenmark P. Crystal structure of the catalytic domain of the Weissela oryzae botulinum-like toxin. Febs Letters. PMID 31111466 DOI: 10.2210/Pdb6Rim/Pdb |
0.322 |
|
| 2019 |
Elliott M, Favre-Guilmard C, Liu SM, Maignel J, Masuyer G, Beard M, Boone C, Carré D, Kalinichev M, Lezmi S, Mir I, Nicoleau C, Palan S, Perier C, Raban E, ... ... Dong M, et al. Engineered botulinum neurotoxin B with improved binding to human receptors has enhanced efficacy in preclinical models. Science Advances. 5: eaau7196. PMID 30746458 DOI: 10.1126/Sciadv.Aau7196 |
0.403 |
|
| 2019 |
Mansfield MJ, Wentz TG, Zhang S, Lee EJ, Dong M, Sharma SK, Doxey AC. Bioinformatic discovery of a toxin family in Chryseobacterium piperi with sequence similarity to botulinum neurotoxins. Scientific Reports. 9: 1634. PMID 30733520 DOI: 10.1038/S41598-018-37647-8 |
0.323 |
|
| 2019 |
Shen Y, Wu SY, Rancic V, Aggarwal A, Qian Y, Miyashita SI, Ballanyi K, Campbell RE, Dong M. Genetically encoded fluorescent indicators for imaging intracellular potassium ion concentration. Communications Biology. 2: 18. PMID 30652129 DOI: 10.1038/s42003-018-0269-2 |
0.491 |
|
| 2018 |
Garland M, Babin BM, Miyashita SI, Loscher S, Shen Y, Dong M, Bogyo M. Covalent modifiers of Botulinum neurotoxin counteract toxin persistence. Acs Chemical Biology. PMID 30571080 DOI: 10.1021/Acschembio.8B00937 |
0.47 |
|
| 2018 |
Tian S, Muneeruddin K, Choi MY, Tao L, Bhuiyan RH, Ohmi Y, Furukawa K, Furukawa K, Boland S, Shaffer SA, Adam RM, Dong M. Genome-wide CRISPR screens for Shiga toxins and ricin reveal Golgi proteins critical for glycosylation. Plos Biology. 16: e2006951. PMID 30481169 DOI: 10.1371/Journal.Pbio.2006951 |
0.571 |
|
| 2018 |
Dong M, Masuyer G, Stenmark P. Botulinum and Tetanus Neurotoxins. Annual Review of Biochemistry. PMID 30388027 DOI: 10.1146/Annurev-Biochem-013118-111654 |
0.432 |
|
| 2018 |
Chen P, Tao L, Liu Z, Dong M, Jin R. Structural insight into Wnt signaling inhibition by Clostridium difficile toxin B. The Febs Journal. PMID 30347517 DOI: 10.1111/Febs.14681 |
0.522 |
|
| 2018 |
Chen P, Tao L, Wang T, Zhang J, He A, Lam KH, Liu Z, He X, Perry K, Dong M, Jin R. Structural basis for recognition of frizzled proteins by toxin B. Science (New York, N.Y.). 360: 664-669. PMID 29748286 DOI: 10.1126/Science.Aar1999 |
0.568 |
|
| 2018 |
Gustafsson R, Zhang S, Masuyer G, Dong M, Stenmark P. Crystal Structure of Botulinum Neurotoxin A2 in Complex with the Human Protein Receptor SV2C Reveals Plasticity in Receptor Binding. Toxins. 10. PMID 29649119 DOI: 10.3390/Toxins10040153 |
0.346 |
|
| 2018 |
Masuyer G, Zhang S, Barkho S, Shen Y, Henriksson L, Košenina S, Dong M, Stenmark P. Structural characterisation of the catalytic domain of botulinum neurotoxin X - high activity and unique substrate specificity. Scientific Reports. 8: 4518. PMID 29540745 DOI: 10.1038/S41598-018-22842-4 |
0.459 |
|
| 2018 |
Zhang S, Lebreton F, Mansfield MJ, Miyashita SI, Zhang J, Schwartzman JA, Tao L, Masuyer G, Martínez-Carranza M, Stenmark P, Gilmore MS, Doxey AC, Dong M. Identification of a Botulinum Neurotoxin-like Toxin in a Commensal Strain of Enterococcus faecium. Cell Host & Microbe. PMID 29396040 DOI: 10.1016/J.Chom.2017.12.018 |
0.547 |
|
| 2018 |
Elliott M, Favre-Guilmard C, Liu SM, Maignel J, Masuyer G, Beard M, Boone C, Carré D, Kalinichev M, Lezmi S, Mir I, Nicoleau C, Palan S, Perier C, Raban E, ... ... Dong M, et al. Botulinum neurotoxin B engineered for increased receptor affinity has improved clinical potential Toxicon. 156: S27-S28. DOI: 10.1016/J.Toxicon.2018.11.070 |
0.308 |
|
| 2017 |
Zhang S, Berntsson RP, Tepp WH, Tao L, Johnson EA, Stenmark P, Dong M. Structural basis for the unique ganglioside and cell membrane recognition mechanism of botulinum neurotoxin DC. Nature Communications. 8: 1637. PMID 29158482 DOI: 10.1038/S41467-017-01534-Z |
0.569 |
|
| 2017 |
Chevalier A, Silva DA, Rocklin GJ, Hicks DR, Vergara R, Murapa P, Bernard SM, Zhang L, Lam KH, Yao G, Bahl CD, Miyashita SI, Goreshnik I, Fuller JT, Koday MT, ... ... Dong M, et al. Massively parallel de novo protein design for targeted therapeutics. Nature. PMID 28953867 DOI: 10.1038/Nature23912 |
0.318 |
|
| 2017 |
Yao G, Lam KH, Weisemann J, Peng L, Krez N, Perry K, Shoemaker CB, Dong M, Rummel A, Jin R. A camelid single-domain antibody neutralizes botulinum neurotoxin A by blocking host receptor binding. Scientific Reports. 7: 7438. PMID 28785006 DOI: 10.1038/S41598-017-07457-5 |
0.435 |
|
| 2017 |
Zhang S, Masuyer G, Zhang J, Shen Y, Lundin D, Henriksson L, Miyashita SI, Martínez-Carranza M, Dong M, Stenmark P. Identification and characterization of a novel botulinum neurotoxin. Nature Communications. 8: 14130. PMID 28770820 DOI: 10.1038/Ncomms14130 |
0.468 |
|
| 2017 |
Tao L, Peng L, Berntsson RP, Liu SM, Park S, Yu F, Boone C, Palan S, Beard M, Chabrier PE, Stenmark P, Krupp J, Dong M. Engineered botulinum neurotoxin B with improved efficacy for targeting human receptors. Nature Communications. 8: 53. PMID 28674381 DOI: 10.1038/S41467-017-00064-Y |
0.575 |
|
| 2016 |
Tao L, Zhang J, Meraner P, Tovaglieri A, Wu X, Gerhard R, Zhang X, Stallcup WB, Miao J, He X, Hurdle JG, Breault DT, Brass AL, Dong M. Frizzled proteins are colonic epithelial receptors for C. difficile toxin B. Nature. PMID 27680706 DOI: 10.1038/Nature19799 |
0.585 |
|
| 2016 |
Yao G, Zhang S, Mahrhold S, Lam KH, Stern D, Bagramyan K, Perry K, Kalkum M, Rummel A, Dong M, Jin R. N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A. Nature Structural & Molecular Biology. PMID 27294781 DOI: 10.1038/Nsmb.3245 |
0.383 |
|
| 2016 |
Berntsson R, Peng L, Henriksson L, Dong M, Stenmark P. Structural and biophysical studies of the binding of botulinum neurotoxin DC to its protein receptors, synaptotagmin I and II Toxicon. 123: S5-S6. DOI: 10.1016/J.Toxicon.2016.11.020 |
0.36 |
|
| 2015 |
Peng L, Adler M, Demogines A, Borrell A, Liu H, Tao L, Tepp WH, Zhang S, Johnson EA, Sawyer SL, Dong M. 157. Variations in VAMP1 across vertebrates suggest a potential selective pressure from botulinum neurotoxins Toxicon. 93: S48-S49. DOI: 10.1016/J.Toxicon.2014.11.160 |
0.568 |
|
| 2014 |
Peng L, Adler M, Demogines A, Borrell A, Liu H, Tao L, Tepp WH, Zhang SC, Johnson EA, Sawyer SL, Dong M. Widespread sequence variations in VAMP1 across vertebrates suggest a potential selective pressure from botulinum neurotoxins. Plos Pathogens. 10: e1004177. PMID 25010769 DOI: 10.1371/Journal.Ppat.1004177 |
0.695 |
|
| 2014 |
Lee K, Zhong X, Gu S, Kruel AM, Dorner MB, Perry K, Rummel A, Dong M, Jin R. Molecular basis for disruption of E-cadherin adhesion by botulinum neurotoxin A complex. Science (New York, N.Y.). 344: 1405-10. PMID 24948737 DOI: 10.1126/Science.1253823 |
0.306 |
|
| 2013 |
Berntsson RP, Peng L, Svensson LM, Dong M, Stenmark P. Crystal structures of botulinum neurotoxin DC in complex with its protein receptors synaptotagmin I and II. Structure (London, England : 1993). 21: 1602-11. PMID 23932591 DOI: 10.1016/J.Str.2013.06.026 |
0.394 |
|
| 2013 |
Berntsson RP, Peng L, Dong M, Stenmark P. Structure of dual receptor binding to botulinum neurotoxin B. Nature Communications. 4: 2058. PMID 23807078 DOI: 10.1038/Ncomms3058 |
0.408 |
|
| 2013 |
Peng L, Liu H, Ruan H, Tepp WH, Stoothoff WH, Brown RH, Johnson EA, Yao WD, Zhang SC, Dong M. Cytotoxicity of botulinum neurotoxins reveals a direct role of syntaxin 1 and SNAP-25 in neuron survival. Nature Communications. 4: 1472. PMID 23403573 DOI: 10.1038/Ncomms2462 |
0.687 |
|
| 2012 |
Wu Y, Gu Y, Morphew MK, Yao J, Yeh FL, Dong M, Chapman ER. All three components of the neuronal SNARE complex contribute to secretory vesicle docking. The Journal of Cell Biology. 198: 323-30. PMID 22869597 DOI: 10.1085/Jgp1403Oia2 |
0.756 |
|
| 2012 |
Peng L, Berntsson RP, Tepp WH, Pitkin RM, Johnson EA, Stenmark P, Dong M. Botulinum neurotoxin D-C uses synaptotagmin I and II as receptors, and human synaptotagmin II is not an effective receptor for type B, D-C and G toxins. Journal of Cell Science. 125: 3233-42. PMID 22454523 DOI: 10.1242/Jcs.103564 |
0.387 |
|
| 2011 |
Peng L, Tepp WH, Johnson EA, Dong M. Botulinum neurotoxin D uses synaptic vesicle protein SV2 and gangliosides as receptors. Plos Pathogens. 7: e1002008. PMID 21483489 DOI: 10.1371/Journal.Ppat.1002008 |
0.477 |
|
| 2011 |
Wang D, Zhang Z, Dong M, Sun S, Chapman ER, Jackson MB. Syntaxin requirement for Ca2+-triggered exocytosis in neurons and endocrine cells demonstrated with an engineered neurotoxin. Biochemistry. 50: 2711-3. PMID 21401123 DOI: 10.1021/Bi200290P |
0.73 |
|
| 2010 |
Yeh FL, Dong M, Yao J, Tepp WH, Lin G, Johnson EA, Chapman ER. SV2 mediates entry of tetanus neurotoxin into central neurons. Plos Pathogens. 6: e1001207. PMID 21124874 DOI: 10.1371/Journal.Ppat.1001207 |
0.762 |
|
| 2010 |
Stenmark P, Dong M, Dupuy J, Chapman ER, Stevens RC. Crystal structure of the botulinum neurotoxin type G binding domain: insight into cell surface binding. Journal of Molecular Biology. 397: 1287-97. PMID 20219474 DOI: 10.1016/J.Jmb.2010.02.041 |
0.617 |
|
| 2009 |
Liu H, Dean C, Arthur CP, Dong M, Chapman ER. Autapses and networks of hippocampal neurons exhibit distinct synaptic transmission phenotypes in the absence of synaptotagmin I. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 7395-403. PMID 19515907 DOI: 10.1523/Jneurosci.1341-09.2009 |
0.753 |
|
| 2008 |
Dong M, Liu H, Tepp WH, Johnson EA, Janz R, Chapman ER. Glycosylated SV2A and SV2B mediate the entry of botulinum neurotoxin E into neurons. Molecular Biology of the Cell. 19: 5226-37. PMID 18815274 DOI: 10.1091/Mbc.E08-07-0765 |
0.744 |
|
| 2007 |
Dong M, Tepp WH, Liu H, Johnson EA, Chapman ER. Mechanism of botulinum neurotoxin B and G entry into hippocampal neurons. The Journal of Cell Biology. 179: 1511-22. PMID 18158333 DOI: 10.1083/Jcb.200707184 |
0.754 |
|
| 2006 |
Chai Q, Arndt JW, Dong M, Tepp WH, Johnson EA, Chapman ER, Stevens RC. Structural basis of cell surface receptor recognition by botulinum neurotoxin B. Nature. 444: 1096-100. PMID 17167418 DOI: 10.1038/Nature05411 |
0.614 |
|
| 2006 |
Dong M, Yeh F, Tepp WH, Dean C, Johnson EA, Janz R, Chapman ER. SV2 is the protein receptor for botulinum neurotoxin A. Science (New York, N.Y.). 312: 592-6. PMID 16543415 DOI: 10.1126/Science.1123654 |
0.788 |
|
| 2004 |
Dong M, Tepp WH, Johnson EA, Chapman ER. Using fluorescent sensors to detect botulinum neurotoxin activity in vitro and in living cells. Proceedings of the National Academy of Sciences of the United States of America. 101: 14701-6. PMID 15465919 DOI: 10.1073/Pnas.0404107101 |
0.55 |
|
| 2003 |
Dong M, Richards DA, Goodnough MC, Tepp WH, Johnson EA, Chapman ER. Synaptotagmins I and II mediate entry of botulinum neurotoxin B into cells. The Journal of Cell Biology. 162: 1293-303. PMID 14504267 DOI: 10.1083/Jcb.200305098 |
0.683 |
|
| 2001 |
Lewis JL, Dong M, Earles CA, Chapman ER. The transmembrane domain of syntaxin 1A is critical for cytoplasmic domain protein-protein interactions. The Journal of Biological Chemistry. 276: 15458-65. PMID 11278966 DOI: 10.1074/Jbc.M011687200 |
0.593 |
|
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