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Stanton L. Gerson - Publications

Case Western Reserve University School of Medicine, Cleveland, OH, United States 
Stem cells, DNA repair

198 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Starr AG, Caimi PF, Fu P, Massoud MR, Meyerson H, Hsi ED, Mansur DB, Cherian S, Singh AD, Cooper BW, De Lima MJ, Lazarus HM, Gerson SL, Jagadeesh D, Smith MR, et al. Dual institution experience of extranodal marginal zone lymphoma reveals excellent long-term outcomes. British Journal of Haematology. PMID 26953041 DOI: 10.1111/bjh.13975  0.92
2016 Nardi EA, Wolfson JA, Rosen ST, Diasio RB, Gerson SL, Parker BA, Alvarnas JC, Levine HA, Fong Y, Weisenburger DD, Fitzgerald CL, Egan M, Stranford S, Carlson RW, Benz EJ. Value, access, and cost of cancer care delivery at academic cancer centers Jnccn Journal of the National Comprehensive Cancer Network. 14: 837-847.  0.92
2015 Chakrabarti G, Silvers MA, Ilcheva M, Liu Y, Moore ZR, Luo X, Gao J, Anderson G, Liu L, Sarode V, Gerber DE, Burma S, DeBerardinis RJ, Gerson SL, Boothman DA. Tumor-selective use of DNA base excision repair inhibition in pancreatic cancer using the NQO1 bioactivatable drug, β-lapachone. Scientific Reports. 5: 17066. PMID 26602448 DOI: 10.1038/srep17066  0.92
2015 Condie AG, Yan Y, Gerson SL, Wang Y. A Fluorescent Probe to Measure DNA Damage and Repair. Plos One. 10: e0131330. PMID 26309022 DOI: 10.1371/journal.pone.0131330  0.92
2015 Caimi PF, William BM, Silva Rondon CH, Fu P, Cooper BW, Campagnaro EL, Gerson SL, Reese-Koc J, Fox R, Creger RJ, de Lima M, Lazarus HM. Comparison of 2 Carmustine-Containing Regimens in the Rituximab Era: Excellent Outcomes Even in Poor-Risk Patients. Biology of Blood and Marrow Transplantation : Journal of the American Society For Blood and Marrow Transplantation. 21: 1926-31. PMID 26087475 DOI: 10.1016/j.bbmt.2015.06.007  0.92
2015 Zhang Y, Desai A, Yang SY, Bae KB, Antczak MI, Fink SP, Tiwari S, Willis JE, Williams NS, Dawson DM, Wald D, Chen WD, Wang Z, Kasturi L, Larusch GA, ... ... Gerson SL, et al. TISSUE REGENERATION. Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration. Science (New York, N.Y.). 348: aaa2340. PMID 26068857 DOI: 10.1126/science.aaa2340  0.92
2015 Afable M, Caimi PF, Hosing C, de Lima M, Khouri I, William BM, Nieto Y, Cooper BW, Anderlini P, Gerson SL, Lazarus HM, Champlin R, Popat U. Hematopoietic Progenitor Cell Harvesting Is Feasible after Treatment with Brentuximab Vedotin in CD30(+) Lymphoma Patients Who Received Multiple Prior Lines of Treatment. Biology of Blood and Marrow Transplantation : Journal of the American Society For Blood and Marrow Transplantation. 21: 1529-31. PMID 25937397 DOI: 10.1016/j.bbmt.2015.04.022  0.92
2015 Adorno-Cruz V, Kibria G, Liu X, Doherty M, Junk DJ, Guan D, Hubert C, Venere M, Mulkearns-Hubert E, Sinyuk M, Alvarado A, Caplan AI, Rich J, Gerson SL, Lathia J, et al. Cancer stem cells: targeting the roots of cancer, seeds of metastasis, and sources of therapy resistance. Cancer Research. 75: 924-9. PMID 25604264 DOI: 10.1158/0008-5472.CAN-14-3225  0.92
2015 Roth JC, Alberti MO, Ismail M, Lingas KT, Reese JS, Gerson SL. MGMT enrichment and second gene co-expression in hematopoietic progenitor cells using separate or dual-gene lentiviral vectors. Virus Research. 196: 170-80. PMID 25479595 DOI: 10.1016/j.virusres.2014.11.027  0.92
2014 Weeks LD, Zentner GE, Scacheri PC, Gerson SL. Uracil DNA glycosylase (UNG) loss enhances DNA double strand break formation in human cancer cells exposed to pemetrexed. Cell Death & Disease. 5: e1045. PMID 24503537 DOI: 10.1038/cddis.2013.477  0.92
2014 Desai A, Webb B, Gerson SL. CD133+ cells contribute to radioresistance via altered regulation of DNA repair genes in human lung cancer cells. Radiotherapy and Oncology : Journal of the European Society For Therapeutic Radiology and Oncology. 110: 538-45. PMID 24440048 DOI: 10.1016/j.radonc.2013.10.040  0.92
2014 Desai A, Qing Y, Gerson SL. Exonuclease 1 is a critical mediator of survival during DNA double strand break repair in nonquiescent hematopoietic stem and progenitor cells. Stem Cells (Dayton, Ohio). 32: 582-93. PMID 24420907 DOI: 10.1002/stem.1596  0.92
2014 Qing Y, Wang Z, Bunting KD, Gerson SL. Bcl2 overexpression rescues the hematopoietic stem cell defects in Ku70-deficient mice by restoration of quiescence. Blood. 123: 1002-11. PMID 24394664 DOI: 10.1182/blood-2013-08-521716  0.92
2013 Weeks LD, Fu P, Gerson SL. Uracil-DNA glycosylase expression determines human lung cancer cell sensitivity to pemetrexed. Molecular Cancer Therapeutics. 12: 2248-60. PMID 23873851 DOI: 10.1158/1535-7163.MCT-13-0172  0.92
2013 Yu WM, Liu X, Shen J, Jovanovic O, Pohl EE, Gerson SL, Finkel T, Broxmeyer HE, Qu CK. Metabolic regulation by the mitochondrial phosphatase PTPMT1 is required for hematopoietic stem cell differentiation. Cell Stem Cell. 12: 62-74. PMID 23290137 DOI: 10.1016/j.stem.2012.11.022  0.92
2013 Gordon MS, Rosen LS, Mendelson D, Ramanathan RK, Goldman J, Liu L, Xu Y, Gerson SL, Anthony SP, Figg WD, Spencer S, Adams BJ, Theuer CP, Leigh BR, Weiss GJ. A phase 1 study of TRC102, an inhibitor of base excision repair, and pemetrexed in patients with advanced solid tumors. Investigational New Drugs. 31: 714-23. PMID 23054206 DOI: 10.1007/s10637-012-9876-9  0.92
2013 Reese JS, Embree H, Thomas SM, Grandis JR, Gerson SL. Issues in Moving Gene Therapy Approaches to Early Clinical Trials Gene Therapy of Cancer: Translational Approaches From Preclinical Studies to Clinical Implementation: Third Edition. 493-501. DOI: 10.1016/B978-0-12-394295-1.00034-2  0.92
2013 Lin Y, Gerson SL. Clinical Trials Using LV-P140K-MGMT for Gliomas Gene Therapy of Cancer: Translational Approaches From Preclinical Studies to Clinical Implementation: Third Edition. 379-391. DOI: 10.1016/B978-0-12-394295-1.00026-3  0.92
2013 Fung H, Gerson SL. Viral Insertion Site Detection and Analysis in Cancer Gene Therapy Gene Therapy of Cancer: Translational Approaches From Preclinical Studies to Clinical Implementation: Third Edition. 35-46. DOI: 10.1016/B978-0-12-394295-1.00003-2  0.92
2013 Lattime EC, Gerson SL. Gene Therapy of Cancer: Translational Approaches from Preclinical Studies to Clinical Implementation: Third Edition Gene Therapy of Cancer: Translational Approaches From Preclinical Studies to Clinical Implementation: Third Edition. 1-537.  0.92
2012 Zhou G, Hamik A, Nayak L, Tian H, Shi H, Lu Y, Sharma N, Liao X, Hale A, Boerboom L, Feaver RE, Gao H, Desai A, Schmaier A, Gerson SL, et al. Endothelial Kruppel-like factor 4 protects against atherothrombosis in mice. The Journal of Clinical Investigation. 122: 4727-31. PMID 23160196 DOI: 10.1172/JCI66056  0.92
2012 Condie AG, Gerson SL, Miller RH, Wang Y. Two-photon fluorescent imaging of myelination in the spinal cord. Chemmedchem. 7: 2194-203. PMID 23136014 DOI: 10.1002/cmdc.201200343  0.92
2012 Roth JC, Ismail M, Reese JS, Lingas KT, Ferrari G, Gerson SL. Cotransduction with MGMT and Ubiquitous or Erythroid-Specific GFP Lentiviruses Allows Enrichment of Dual-Positive Hematopoietic Progenitor Cells In Vivo. Isrn Hematology. 2012: 212586. PMID 22888445 DOI: 10.5402/2012/212586  0.68
2012 Falahati R, Zhang J, Flebbe-Rehwaldt L, Shi Y, Gerson SL, Gaensler KM. Chemoselection of allogeneic HSC after murine neonatal transplantation without myeloablation or post-transplant immunosuppression. Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 2180-9. PMID 22871662 DOI: 10.1038/mt.2012.136  0.92
2012 Yang S, Savvides P, Liu L, Gerson SL, Xu Y. Development and validation of an LC-MS/MS method for pharmacokinetic study of methoxyamine in phase I clinical trial. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 901: 25-33. PMID 22743337 DOI: 10.1016/j.jchromb.2012.05.036  0.92
2012 Kenyon J, Fu P, Lingas K, Thomas E, Saurastri A, Santos Guasch G, Wald D, Gerson SL. Humans accumulate microsatellite instability with acquired loss of MLH1 protein in hematopoietic stem and progenitor cells as a function of age. Blood. 120: 3229-36. PMID 22740444 DOI: 10.1182/blood-2011-12-401950  0.92
2012 Alberti MO, Roth JC, Ismail M, Tsuruta Y, Abraham E, Pereboeva L, Gerson SL, Curiel DT. Derivation of a myeloid cell-binding adenovirus for gene therapy of inflammation. Plos One. 7: e37812. PMID 22624065 DOI: 10.1371/journal.pone.0037812  0.92
2012 Fontes AM, Melo FU, Greene LJ, Faça VM, Lin Y, Gerson SL, Covas DT. Production of human factor VIII-FL in 293T cells using the bicistronic MGMT(P140K)-retroviral vector. Genetics and Molecular Research : Gmr. 11: 775-89. PMID 22576836 DOI: 10.4238/2012.March.22.8  0.92
2012 Apisarnthanarax N, Wood GS, Stevens SR, Carlson S, Chan DV, Liu L, Szabo SK, Fu P, Gilliam AC, Gerson SL, Remick SC, Cooper KD. Phase I clinical trial of O6-benzylguanine and topical carmustine in the treatment of cutaneous T-cell lymphoma, mycosis fungoides type. Archives of Dermatology. 148: 613-20. PMID 22250189 DOI: 10.1001/archdermatol.2011.2797  0.92
2012 Bulgar AD, Weeks LD, Miao Y, Yang S, Xu Y, Guo C, Markowitz S, Oleinick N, Gerson SL, Liu L. Removal of uracil by uracil DNA glycosylase limits pemetrexed cytotoxicity: overriding the limit with methoxyamine to inhibit base excision repair. Cell Death & Disease. 3: e252. PMID 22237209 DOI: 10.1038/cddis.2011.135  0.92
2012 Qing Y, Lin Y, Gerson SL. An intrinsic BM hematopoietic niche occupancy defect of HSC in scid mice facilitates exogenous HSC engraftment. Blood. 119: 1768-71. PMID 22147896 DOI: 10.1182/blood-2011-05-350611  0.92
2012 Kindwall-Keller TL, Hegerfeldt Y, Meyerson HJ, Margevicius S, Fu P, van Heeckeren W, Lazarus HM, Cooper BW, Gerson SL, Barr P, Tse WW, Curtis C, Fanning LR, Creger RJ, Carlson-Barko JM, et al. Prospective study of one- vs two-unit umbilical cord blood transplantation following reduced intensity conditioning in adults with hematological malignancies. Bone Marrow Transplantation. 47: 924-33. PMID 22002488 DOI: 10.1038/bmt.2011.195  0.92
2012 Liu L, Lin Y, Gerson SL. MGMT: A Critical DNA Repair Gene Target for Chemotherapy Resistance and for Stem Cell Protection Dna Repair in Cancer Therapy. 17-28. DOI: 10.1016/B978-0-12-384999-1.10002-2  0.92
2011 Xu D, Liu X, Yu WM, Meyerson HJ, Guo C, Gerson SL, Qu CK. Non-lineage/stage-restricted effects of a gain-of-function mutation in tyrosine phosphatase Ptpn11 (Shp2) on malignant transformation of hematopoietic cells. The Journal of Experimental Medicine. 208: 1977-88. PMID 21930766 DOI: 10.1084/jem.20110450  0.92
2011 Lazarus HM, Sommers SR, Arfons LM, Fu P, Ataergin SA, Kaye NM, Liu F, Kindwall-Keller TL, Cooper BW, Laughlin MJ, Creger RJ, Barr PM, Gerson SL, Kaplan D. Spontaneous autologous graft-versus-host disease in plasma cell myeloma autograft recipients: flow cytometric analysis of hematopoietic progenitor cell grafts. Biology of Blood and Marrow Transplantation : Journal of the American Society For Blood and Marrow Transplantation. 17: 970-8. PMID 21440080 DOI: 10.1016/j.bbmt.2011.03.005  0.92
2011 Lin Y, Cheung P, Roth JC, Wilson DL, Gerson SL. Imaging stem cell-derived persistent foci after in vivo selection of lentiviral MGMT-P140K transduced murine bone marrow cells. Molecular Therapy : the Journal of the American Society of Gene Therapy. 19: 1342-52. PMID 21304493 DOI: 10.1038/mt.2010.315  0.92
2011 Athanasiou MC, Dettling M, Cascorbi I, Mosyagin I, Salisbury BA, Pierz KA, Zou W, Whalen H, Malhotra AK, Lencz T, Gerson SL, Kane JM, Reed CR. Candidate gene analysis identifies a polymorphism in HLA-DQB1 associated with clozapine-induced agranulocytosis. The Journal of Clinical Psychiatry. 72: 458-63. PMID 20868635 DOI: 10.4088/JCP.09m05527yel  0.92
2011 Lin Y, Gerson SL. Hematopoiesis Concise Guide to Hematology. 6-15. DOI: 10.1002/9781444345254.ch2  0.92
2010 Bulgar AD, Snell M, Donze JR, Kirkland EB, Li L, Yang S, Xu Y, Gerson SL, Liu L. Targeting base excision repair suggests a new therapeutic strategy of fludarabine for the treatment of chronic lymphocytic leukemia. Leukemia. 24: 1795-9. PMID 20811400 DOI: 10.1038/leu.2010.166  0.92
2010 Rizzieri D, LoRusso S, Tse W, Khan K, Advani A, Moore J, Karsten V, Cahill A, Gerson SL. Phase I study of temozolomide and laromustine (VNP40101M) in patients with relapsed or refractory leukemia. Clinical Lymphoma, Myeloma & Leukemia. 10: 211-6. PMID 20511167 DOI: 10.3816/CLML.2010.n.033  0.92
2009 Wang Y, Liu L, Wu C, Bulgar A, Somoza E, Zhu W, Gerson SL. Direct detection and quantification of abasic sites for in vivo studies of DNA damage and repair. Nuclear Medicine and Biology. 36: 975-83. PMID 19875055 DOI: 10.1016/j.nucmedbio.2009.07.007  0.92
2009 Barr PM, Fu P, Lazarus HM, Horvath N, Gerson SL, Koc ON, Bahlis NJ, Snell MR, Dowlati A, Cooper BW. Phase I trial of fludarabine, bortezomib and rituximab for relapsed and refractory indolent and mantle cell non-Hodgkin lymphoma. British Journal of Haematology. 147: 89-96. PMID 19656151 DOI: 10.1111/j.1365-2141.2009.07836.x  0.92
2009 Strunk CJ, Platzbecker U, Thiede C, Schaich M, Illmer T, Kang Z, Leahy P, Li C, Xie X, Laughlin MJ, Lazarus HM, Gerson SL, Bunting KD, Ehninger G, Tse W. Elevated AF1q expression is a poor prognostic marker for adult acute myeloid leukemia patients with normal cytogenetics. American Journal of Hematology. 84: 308-9. PMID 19396856 DOI: 10.1002/ajh.21396  0.92
2009 Kisby GE, Olivas A, Park T, Churchwell M, Doerge D, Samson LD, Gerson SL, Turker MS. DNA repair modulates the vulnerability of the developing brain to alkylating agents. Dna Repair. 8: 400-12. PMID 19162564 DOI: 10.1016/j.dnarep.2008.12.002  0.92
2009 Wang F, Dennis JE, Awadallah A, Solchaga LA, Molter J, Kuang Y, Salem N, Lin Y, Tian H, Kolthammer JA, Kim Y, Love ZB, Gerson SL, Lee Z. Transcriptional profiling of human mesenchymal stem cells transduced with reporter genes for imaging. Physiological Genomics. 37: 23-34. PMID 19116247 DOI: 10.1152/physiolgenomics.00300.2007  0.92
2008 Moioli EK, Clark PA, Chen M, Dennis JE, Erickson HP, Gerson SL, Mao JJ. Synergistic actions of hematopoietic and mesenchymal stem/progenitor cells in vascularizing bioengineered tissues. Plos One. 3: e3922. PMID 19081793 DOI: 10.1371/journal.pone.0003922  0.92
2008 Wald DN, Vermaat HM, Zang S, Lavik A, Kang Z, Peleg G, Gerson SL, Bunting KD, Agarwal ML, Roth BL, Tse W. Identification of 6-benzylthioinosine as a myeloid leukemia differentiation-inducing compound. Cancer Research. 68: 4369-76. PMID 18519698 DOI: 10.1158/0008-5472.CAN-07-6559  0.92
2008 Lee Z, Dennis JE, Gerson SL. Imaging stem cell implant for cellular-based therapies. Experimental Biology and Medicine (Maywood, N.J.). 233: 930-40. PMID 18480418 DOI: 10.3181/0709-MR-234  0.92
2008 Lin Y, Molter J, Lee Z, Gerson SL. Bioluminescence imaging of hematopoietic stem cell repopulation in murine models. Methods in Molecular Biology (Clifton, N.J.). 430: 295-306. PMID 18370307 DOI: 10.1007/978-1-59745-182-6_20  0.92
2008 Gururangan S, Turner CD, Stewart CF, O'Shaughnessy M, Kocak M, Poussaint TY, Phillips PC, Goldman S, Packer R, Pollack IF, Blaney SM, Karsten V, Gerson SL, Boyett JM, Friedman HS, et al. Phase I trial of VNP40101M (Cloretazine) in children with recurrent brain tumors: a pediatric brain tumor consortium study. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 14: 1124-30. PMID 18281546 DOI: 10.1158/1078-0432.CCR-07-4242  0.92
2008 Gao Y, Lobritz MA, Roth J, Abreha M, Nelson KN, Nankya I, Moore-Dudley DM, Abraha A, Gerson SL, Arts EJ. Targets of small interfering RNA restriction during human immunodeficiency virus type 1 replication. Journal of Virology. 82: 2938-51. PMID 18199654 DOI: 10.1128/JVI.02126-07  0.92
2008 Reese JS, Roth JC, Gerson SL. Bone marrow-derived cells exhibiting lung epithelial cell characteristics are enriched in vivo using methylguanine DNA methyltransferase-mediated drug resistance. Stem Cells (Dayton, Ohio). 26: 675-81. PMID 18192231 DOI: 10.1634/stemcells.2007-0803  0.92
2008 Fu P, van Heeckeren WJ, Wadhwa PD, Bajor DJ, Creger RJ, Xu Z, Cooper BW, Laughlin MJ, Gerson SL, Koç ON, Lazarus HM. Time-dependent effect of non-Hodgkin's lymphoma grade on disease-free survival of relapsed/refractory patients treated with high-dose chemotherapy plus autotransplantation. Contemporary Clinical Trials. 29: 157-64. PMID 17707140 DOI: 10.1016/j.cct.2007.07.005  0.92
2007 Kenyon J, Gerson SL. The role of DNA damage repair in aging of adult stem cells. Nucleic Acids Research. 35: 7557-65. PMID 18160407 DOI: 10.1093/nar/gkm1064  0.92
2007 Batts ED, Maisel C, Kane D, Liu L, Fu P, O'Brien T, Remick S, Bahlis N, Gerson SL. O6-benzylguanine and BCNU in multiple myeloma: a phase II trial. Cancer Chemotherapy and Pharmacology. 60: 415-21. PMID 17354015 DOI: 10.1007/s00280-007-0442-7  0.92
2007 Yan L, Bulgar A, Miao Y, Mahajan V, Donze JR, Gerson SL, Liu L. Combined treatment with temozolomide and methoxyamine: blocking apurininc/pyrimidinic site repair coupled with targeting topoisomerase IIalpha. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 13: 1532-9. PMID 17332299 DOI: 10.1158/1078-0432.CCR-06-1595  0.92
2006 Gerson SL, Reese J, Kenyon J. DNA repair in stem cell maintenance and conversion to cancer stem cells. Ernst Schering Foundation Symposium Proceedings. 231-44. PMID 17939304  0.92
2006 Fu P, Bagai RK, Meyerson H, Kane D, Fox RM, Creger RJ, Cooper BW, Gerson SL, Laughlin MJ, Koc ON, Lazarus HM. Pre-mobilization therapy blood CD34+ cell count predicts the likelihood of successful hematopoietic stem cell mobilization. Bone Marrow Transplantation. 38: 189-96. PMID 16850032 DOI: 10.1038/sj.bmt.1705431  0.92
2006 Yüksel M, Baron E, Camouse M, Cooper BW, Lazarus HM, Gerson SL, Laughlin MJ, Cooper KD, Gilliam A, Fu P, Stevens S, Koç ON. Peritransplant use of ultraviolet-B irradiation (UV-B) therapy is detrimental to allogeneic stem cell transplantation outcome. Biology of Blood and Marrow Transplantation : Journal of the American Society For Blood and Marrow Transplantation. 12: 665-71. PMID 16737940 DOI: 10.1016/j.bbmt.2006.02.004  0.92
2006 An FQ, Folarin HM, Compitello N, Roth J, Gerson SL, McCrae KR, Fakhari FD, Dittmer DP, Renne R. Long-term-infected telomerase-immortalized endothelial cells: a model for Kaposi's sarcoma-associated herpesvirus latency in vitro and in vivo. Journal of Virology. 80: 4833-46. PMID 16641275 DOI: 10.1128/JVI.80.10.4833-4846.2006  0.92
2006 Fontes AM, Davis BM, Encell LP, Lingas K, Covas DT, Zago MA, Loeb LA, Pegg AE, Gerson SL. Differential competitive resistance to methylating versus chloroethylating agents among five O6-alkylguanine DNA alkyltransferases in human hematopoietic cells. Molecular Cancer Therapeutics. 5: 121-8. PMID 16432170 DOI: 10.1158/1535-7163.MCT-05-0236  0.92
2006 Liu L, Gerson SL. Targeted modulation of MGMT: clinical implications. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 12: 328-31. PMID 16428468 DOI: 10.1158/1078-0432.CCR-05-2543  0.92
2006 van Heeckeren WJ, Vollweiler J, Fu P, Cooper BW, Meyerson H, Lazarus HM, Simic A, Laughlin MJ, Gerson SL, Koç ON. Randomised comparison of two B-cell purging protocols for patients with B-cell non-Hodgkin lymphoma: in vivo purging with rituximab versus ex vivo purging with CliniMACS CD34 cell enrichment device. British Journal of Haematology. 132: 42-55. PMID 16371019 DOI: 10.1111/j.1365-2141.2005.05827.x  0.92
2006 Gerson SL. To the editor [3] New England Journal of Medicine. 354: 1847.  0.92
2005 Gajewski TF, Sosman J, Gerson SL, Liu L, Dolan E, Lin S, Vokes EE. Phase II trial of the O6-alkylguanine DNA alkyltransferase inhibitor O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea in advanced melanoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 11: 7861-5. PMID 16278409 DOI: 10.1158/1078-0432.CCR-05-0060  0.92
2005 Bahlis NJ, Miao Y, Koc ON, Lee K, Boise LH, Gerson SL. N-benzoylstaurosporine (PKC412) inhibits Akt kinase inducing apoptosis in multiple myeloma cells. Leukemia & Lymphoma. 46: 899-908. PMID 16019536 DOI: 10.1080/10428190500080595  0.92
2005 Lazarus HM, Koc ON, Devine SM, Curtin P, Maziarz RT, Holland HK, Shpall EJ, McCarthy P, Atkinson K, Cooper BW, Gerson SL, Laughlin MJ, Loberiza FR, Moseley AB, Bacigalupo A. Cotransplantation of HLA-identical sibling culture-expanded mesenchymal stem cells and hematopoietic stem cells in hematologic malignancy patients. Biology of Blood and Marrow Transplantation : Journal of the American Society For Blood and Marrow Transplantation. 11: 389-98. PMID 15846293 DOI: 10.1016/j.bbmt.2005.02.001  0.92
2005 Park Y, Gerson SL. DNA repair defects in stem cell function and aging. Annual Review of Medicine. 56: 495-508. PMID 15660524 DOI: 10.1146/  0.92
2005 Wadhwa PD, Fu P, Koc ON, Cooper BW, Fox RM, Creger RJ, Bajor DL, Bedi T, Laughlin MJ, Payne J, Gerson SL, Lazarus HM. High-dose carmustine, etoposide, and cisplatin for autologous stem cell transplantation with or without involved-field radiation for relapsed/refractory lymphoma: an effective regimen with low morbidity and mortality. Biology of Blood and Marrow Transplantation : Journal of the American Society For Blood and Marrow Transplantation. 11: 13-22. PMID 15625540 DOI: 10.1016/j.bbmt.2004.09.003  0.92
2005 Gerson SL. Selection without harm: Drug resistance gene therapy hits the big time Blood. 105: 914. DOI: 10.1182/blood-2004-11-4251  0.92
2004 Cooper BW, Veal GJ, Radivoyevitch T, Tilby MJ, Meyerson HJ, Lazarus HM, Koc ON, Creger RJ, Pearson G, Nowell GM, Gosky D, Ingalls ST, Hoppel CL, Gerson SL. A phase I and pharmacodynamic study of fludarabine, carboplatin, and topotecan in patients with relapsed, refractory, or high-risk acute leukemia. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 6830-9. PMID 15501959 DOI: 10.1158/1078-0432.CCR-04-0097  0.92
2004 Richard E, Robert E, Cario-André M, Ged C, Géronimi F, Gerson SL, de Verneuil H, Moreau-Gaudry F. Hematopoietic stem cell gene therapy of murine protoporphyria by methylguanine-DNA-methyltransferase-mediated in vivo drug selection. Gene Therapy. 11: 1638-47. PMID 15284838 DOI: 10.1038/  0.92
2004 Liu L, Gerson SL. Therapeutic impact of methoxyamine: blocking repair of abasic sites in the base excision repair pathway. Current Opinion in Investigational Drugs (London, England : 2000). 5: 623-7. PMID 15242251  0.92
2004 Zielske SP, Lingas KT, Li Y, Gerson SL. Limited lentiviral transgene expression with increasing copy number in an MGMT selection model: lack of copy number selection by drug treatment. Molecular Therapy : the Journal of the American Society of Gene Therapy. 9: 923-31. PMID 15194059 DOI: 10.1016/j.ymthe.2004.02.017  0.92
2004 Gerson SL. MGMT: its role in cancer aetiology and cancer therapeutics. Nature Reviews. Cancer. 4: 296-307. PMID 15057289 DOI: 10.1038/nrc1319  0.92
2004 Hammond LA, Eckardt JR, Kuhn JG, Gerson SL, Johnson T, Smith L, Drengler RL, Campbell E, Weiss GR, Von Hoff DD, Rowinsky EK. A randomized phase I and pharmacological trial of sequences of 1,3-bis(2-chloroethyl)-1-nitrosourea and temozolomide in patients with advanced solid neoplasms. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 1645-56. PMID 15014015 DOI: 10.1158/1078-0432.CCR-03-0174  0.92
2003 Dowlati A, Lazarus HM, Hartman P, Jacobberger JW, Whitacre C, Gerson SL, Ksenich P, Cooper BW, Frisa PS, Gottlieb M, Murgo AJ, Remick SC. Phase I and correlative study of combination bryostatin 1 and vincristine in relapsed B-cell malignancies. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 9: 5929-35. PMID 14676117  0.92
2003 Zielske SP, Reese JS, Lingas KT, Donze JR, Gerson SL. In vivo selection of MGMT(P140K) lentivirus-transduced human NOD/SCID repopulating cells without pretransplant irradiation conditioning. The Journal of Clinical Investigation. 112: 1561-70. PMID 14617757 DOI: 10.1172/JCI17922  0.92
2003 Liu L, Yan L, Donze JR, Gerson SL. Blockage of abasic site repair enhances antitumor efficacy of 1,3-bis-(2-chloroethyl)-1-nitrosourea in colon tumor xenografts. Molecular Cancer Therapeutics. 2: 1061-6. PMID 14578471  0.92
2003 Yang S, Liu L, Gerson SL, Xu Y. Measurement of anti-cancer agent methoxyamine in plasma by tandem mass spectrometry with on-line sample extraction. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 795: 295-307. PMID 14522034 DOI: 10.1016/S1570-0232(03)00594-4  0.92
2003 Davis BM, Reese JS, Lingas K, Gerson SL. Drug selection of mutant methylguanine methyltransferase from different oncoretroviral backbones results in multilineage hematopoietic transgene expression in primary and secondary recipients. Journal of Hematotherapy & Stem Cell Research. 12: 375-87. PMID 12965075 DOI: 10.1089/152581603322286015  0.92
2003 Tserng KY, Ingalls ST, Boczko EM, Spiro TP, Li X, Majka S, Gerson SL, Willson JK, Hoppel CL. Pharmacokinetics of O6-benzylguanine (NSC637037) and its metabolite, 8-oxo-O6-benzylguanine. Journal of Clinical Pharmacology. 43: 881-93. PMID 12953345 DOI: 10.1177/0091270003256060  0.92
2003 Richard E, Géronimi F, Lalanne M, Ged C, Redonnet-Vernhet I, Lamrissi-Garcia I, Gerson SL, de Verneuil H, Moreau-Gaudry F. A bicistronic SIN-lentiviral vector containing G156A MGMT allows selection and metabolic correction of hematopoietic protoporphyric cell lines. The Journal of Gene Medicine. 5: 737-47. PMID 12950064 DOI: 10.1002/jgm.407  0.92
2003 Koç ON, Gerson SL. Akt helps stem cells heal the heart. Nature Medicine. 9: 1109-10. PMID 12949518 DOI: 10.1038/nm0903-1109  0.92
2003 Odago FO, Gerson SL. Telomerase inhibition and telomere erosion: a two-pronged strategy in cancer therapy. Trends in Pharmacological Sciences. 24: 328-31. PMID 12871663 DOI: 10.1016/S0165-6147(03)00165-2  0.92
2003 Zielske SP, Gerson SL. SarCNU mediates selection of P140K methylguanine-DNA-methyltransferase transduced human CD34(+) cells in vitro. Blood Cells, Molecules & Diseases. 31: 48-50. PMID 12850483 DOI: 10.1016/S1079-9796(03)00060-3  0.92
2003 Bowman JE, Reese JS, Lingas KT, Gerson SL. Myeloablation is not required to select and maintain expression of the drug-resistance gene, mutant MGMT, in primary and secondary recipients. Molecular Therapy : the Journal of the American Society of Gene Therapy. 8: 42-50. PMID 12842427 DOI: 10.1016/S1525-0016(03)00141-2  0.92
2003 Vollweiler JL, Zielske SP, Reese JS, Gerson SL. Hematopoietic stem cell gene therapy: progress toward therapeutic targets. Bone Marrow Transplantation. 32: 1-7. PMID 12815471 DOI: 10.1038/sj.bmt.1704081  0.92
2003 Reese JS, Liu L, Gerson SL. Repopulating defect of mismatch repair-deficient hematopoietic stem cells. Blood. 102: 1626-33. PMID 12730104 DOI: 10.1182/blood-2002-10-3035  0.92
2003 Tolcher AW, Gerson SL, Denis L, Geyer C, Hammond LA, Patnaik A, Goetz AD, Schwartz G, Edwards T, Reyderman L, Statkevich P, Cutler DL, Rowinsky EK. Marked inactivation of O6-alkylguanine-DNA alkyltransferase activity with protracted temozolomide schedules. British Journal of Cancer. 88: 1004-11. PMID 12671695 DOI: 10.1038/sj.bjc.6600827  0.92
2003 Zielske SP, Gerson SL. Cytokines, including stem cell factor alone, enhance lentiviral transduction in nondividing human LTCIC and NOD/SCID repopulating cells. Molecular Therapy : the Journal of the American Society of Gene Therapy. 7: 325-33. PMID 12668128 DOI: 10.1016/S1525-0016(03)00005-4  0.92
2003 Cooper BW, Donaher E, Lazarus HM, Green SB, Gosky DM, Rosenthal NS, Berger SJ, Li X, Ingalls ST, Hoppel CL, Gerson SL. A phase I and pharmacodynamic study of sequential topotecan and etoposide in patients with relapsed or refractory acute myelogenous and lymphoblastic leukemia. Leukemia Research. 27: 35-44. PMID 12479850 DOI: 10.1016/S0145-2126(02)00079-6  0.92
2002 Zhou H, Liu L, Lee K, Qin X, Grasso AW, Kung HJ, Willis JE, Kern J, Wagner T, Gerson SL. Lung tumorigenesis associated with erb-B-2 and erb-B-3 overexpression in human erb-B-3 transgenic mice is enhanced by methylnitrosourea. Oncogene. 21: 8732-40. PMID 12483526 DOI: 10.1038/sj.onc.1205984  0.92
2002 Liu L, Nakatsuru Y, Gerson SL. Base excision repair as a therapeutic target in colon cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 8: 2985-91. PMID 12231545  0.92
2002 Koç ON, Day J, Nieder M, Gerson SL, Lazarus HM, Krivit W. Allogeneic mesenchymal stem cell infusion for treatment of metachromatic leukodystrophy (MLD) and Hurler syndrome (MPS-IH). Bone Marrow Transplantation. 30: 215-22. PMID 12203137 DOI: 10.1038/sj.bmt.1703650  0.92
2002 Gerson SL, Kaplan SL, Bruss JB, Le V, Arellano FM, Hafkin B, Kuter DJ. Hematologic effects of linezolid: summary of clinical experience. Antimicrobial Agents and Chemotherapy. 46: 2723-6. PMID 12121967 DOI: 10.1128/AAC.46.8.2723-2726.2002  0.92
2002 Ballas CB, Zielske SP, Gerson SL. Adult bone marrow stem cells for cell and gene therapies: implications for greater use. Journal of Cellular Biochemistry. Supplement. 38: 20-8. PMID 12046846  0.92
2002 Liu L, Schwartz S, Davis BM, Gerson SL. Chemotherapy-induced O(6)-benzylguanine-resistant alkyltransferase mutations in mismatch-deficient colon cancer. Cancer Research. 62: 3070-6. PMID 12036916  0.92
2002 Gerson SL. Clinical relevance of MGMT in the treatment of cancer. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 20: 2388-99. PMID 11981013 DOI: 10.1200/JCO.2002.06.110  0.92
2002 Zielske SP, Gerson SL. Lentiviral transduction of P140K MGMT into human CD34(+) hematopoietic progenitors at low multiplicity of infection confers significant resistance to BG/BCNU and allows selection in vitro. Molecular Therapy : the Journal of the American Society of Gene Therapy. 5: 381-7. PMID 11945064 DOI: 10.1006/mthe.2002.0571  0.92
2002 Wadhwa PD, Zielske SP, Roth JC, Ballas CB, Bowman JE, Gerson SL. Cancer gene therapy: scientific basis. Annual Review of Medicine. 53: 437-52. PMID 11818484 DOI: 10.1146/  0.92
2002 Ballas CB, Zielske SP, Gerson SL. Stem cells and the philosopher's stone Journal of Cellular Biochemistry. 85: 13-19. DOI: 10.1002/jcb.10098  0.92
2001 Lee K, Gerson SL, Maitra B, Koç ON. G156A MGMT-transduced human mesenchymal stem cells can be selectively enriched by O6-benzylguanine and BCNU. Journal of Hematotherapy & Stem Cell Research. 10: 691-701. PMID 11672516 DOI: 10.1089/152581601753193913  0.92
2001 Dowlati A, Haaga J, Remick SC, Spiro TP, Gerson SL, Liu L, Berger SJ, Berger NA, Willson JK. Sequential tumor biopsies in early phase clinical trials of anticancer agents for pharmacodynamic evaluation. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 7: 2971-6. PMID 11595684  0.92
2001 Zhou H, Chen WD, Qin X, Lee K, Liu L, Markowitz SD, Gerson SL. MMTV promoter hypomethylation is linked to spontaneous and MNU associated c-neu expression and mammary carcinogenesis in MMTV c-neu transgenic mice. Oncogene. 20: 6009-17. PMID 11593408 DOI: 10.1038/sj.onc.1204830  0.92
2001 Taverna P, Liu L, Hwang HS, Hanson AJ, Kinsella TJ, Gerson SL. Methoxyamine potentiates DNA single strand breaks and double strand breaks induced by temozolomide in colon cancer cells. Mutation Research. 485: 269-81. PMID 11585361 DOI: 10.1016/S0921-8777(01)00076-3  0.92
2001 Reese JS, Allay E, Gerson SL. Overexpression of human O6-alkylguanine DNA alkyltransferase (AGT) prevents MNU induced lymphomas in heterozygous p53 deficient mice. Oncogene. 20: 5258-63. PMID 11536039 DOI: 10.1038/sj.onc.1204700  0.92
2001 Liu L, Spiro TP, Qin X, Majka S, Haaga J, Schupp J, Willson JK, Gerson SL. Differential degradation rates of inactivated alkyltransferase in blood mononuclear cells and tumors of patients after treatment with O(6)-benzylguanine. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 7: 2318-24. PMID 11489807  0.92
2001 Spiro TP, Liu L, Majka S, Haaga J, Willson JK, Gerson SL. Temozolomide: the effect of once- and twice-a-day dosing on tumor tissue levels of the DNA repair protein O(6)-alkylguanine-DNA-alkyltransferase. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 7: 2309-17. PMID 11489806  0.92
2001 Laughlin MJ, Barker J, Bambach B, Koc ON, Rizzieri DA, Wagner JE, Gerson SL, Lazarus HM, Cairo M, Stevens CE, Rubinstein P, Kurtzberg J. Hematopoietic engraftment and survival in adult recipients of umbilical-cord blood from unrelated donors. The New England Journal of Medicine. 344: 1815-22. PMID 11407342 DOI: 10.1056/NEJM200106143442402  0.92
2001 Dowlati A, Hoppel CL, Ingalls ST, Majka S, Li X, Sedransk N, Spiro T, Gerson SL, Ivy P, Remick SC. Phase I clinical and pharmacokinetic study of rebeccamycin analog NSC 655649 given daily for five consecutive days. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 19: 2309-18. PMID 11304785  0.92
2001 Davis BM, Encell LP, Zielske SP, Christians FC, Liu L, Friebert SE, Loeb LA, Gerson SL. Applied molecular evolution of O6-benzylguanine-resistant DNA alkyltransferases in human hematopoietic cells. Proceedings of the National Academy of Sciences of the United States of America. 98: 4950-4. PMID 11296271 DOI: 10.1073/pnas.091601198  0.92
2001 Reese JS, Qin X, Ballas CB, Sekiguchi M, Gerson SL. MGMT expression in murine bone marrow is a major determinant of animal survival after alkylating agent exposure. Journal of Hematotherapy & Stem Cell Research. 10: 115-23. PMID 11276365 DOI: 10.1089/152581601750098354  0.92
2001 Johnsen AK, France J, Nagy N, Askew D, Abdul-Karim FW, Gerson SL, Sy MS, Harding CV. Systemic deficits in transporter for antigen presentation (TAP)-1 or proteasome subunit LMP2 have little or no effect on tumor incidence. International Journal of Cancer. Journal International Du Cancer. 91: 366-72. PMID 11169961 DOI: 10.1002/1097-0215(200002)9999:9999<::AID-IJC1056>3.0.CO;2-K  0.92
2000 Majumdar MK, Thiede MA, Haynesworth SE, Bruder SP, Gerson SL. Human marrow-derived mesenchymal stem cells (MSCs) express hematopoietic cytokines and support long-term hematopoiesis when differentiated toward stromal and osteogenic lineages. Journal of Hematotherapy & Stem Cell Research. 9: 841-8. PMID 11177595 DOI: 10.1089/152581600750062264  0.92
2000 Gerson SL. Drug resistance gene transfer: Stem cell protection and therapeutic efficacy. Experimental Hematology. 28: 1315-24. PMID 11146153 DOI: 10.1016/S0301-472X(00)00548-8  0.92
2000 Taverna P, Liu L, Hanson AJ, Monks A, Gerson SL. Characterization of MLH1 and MSH2 DNA mismatch repair proteins in cell lines of the NCI anticancer drug screen. Cancer Chemotherapy and Pharmacology. 46: 507-16. PMID 11138465 DOI: 10.1007/s002800000186  0.92
2000 Chen R, Nagarajan S, Prince GM, Maheshwari U, Terstappen LW, Kaplan DR, Gerson SL, Albert JM, Dunn DE, Lazarus HM, Medof ME. Impaired growth and elevated fas receptor expression in PIGA(+) stem cells in primary paroxysmal nocturnal hemoglobinuria. The Journal of Clinical Investigation. 106: 689-96. PMID 10974022 DOI: 10.1172/JCI8328  0.92
2000 Davis BM, Koç ON, Gerson SL. Limiting numbers of G156A O(6)-methylguanine-DNA methyltransferase-transduced marrow progenitors repopulate nonmyeloablated mice after drug selection. Blood. 95: 3078-84. PMID 10807772  0.92
2000 Koç ON, Gerson SL, Cooper BW, Laughlin M, Meyerson H, Kutteh L, Fox RM, Szekely EM, Tainer N, Lazarus HM. Randomized cross-over trial of progenitor-cell mobilization: high-dose cyclophosphamide plus granulocyte colony-stimulating factor (G-CSF) versus granulocyte-macrophage colony-stimulating factor plus G-CSF. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 18: 1824-30. PMID 10784622  0.92
2000 Qin X, Shibata D, Gerson SL. Heterozygous DNA mismatch repair gene PMS2-knockout mice are susceptible to intestinal tumor induction with N-methyl-N-nitrosourea. Carcinogenesis. 21: 833-8. PMID 10753224  0.92
2000 Lazarus HM, Pecora AL, Shea TC, Koç ON, White JM, Gabriel DA, Cooper BW, Gerson SL, Krieger M, Sing AP. CD34+ selection of hematopoietic blood cell collections and autotransplantation in lymphoma: overnight storage of cells at 4 degrees C does not affect outcome. Bone Marrow Transplantation. 25: 559-66. PMID 10713636 DOI: 10.1038/sj.bmt.1702175  0.92
2000 Koç ON, Gerson SL, Cooper BW, Dyhouse SM, Haynesworth SE, Caplan AI, Lazarus HM. Rapid hematopoietic recovery after coinfusion of autologous-blood stem cells and culture-expanded marrow mesenchymal stem cells in advanced breast cancer patients receiving high-dose chemotherapy. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 18: 307-16. PMID 10637244  0.92
2000 Zielske SP, Gerson SL. Drug resistance of human hematopoietic stem cells transduced with mgmt p140k using a lentiviral vector at low multiplicity of infection Blood. 96.  0.92
2000 Reese JS, Liu L, Gerson SL. Mismatch repair deficient hematopoietic stem cells have an early selection advantage/a vivo but experience late exhaustion after methylating agent exposure Blood. 96.  0.92
2000 Bowman JE, Davis BM, Gerson SL. Competitive in vivo selection for MFG-P140K MGMT and MFG-G156A MGMT transduced murine progenitors in secondary recipient mice using o6-benzylguanine and bcnu Blood. 96.  0.92
2000 Wadhwa PD, Roth JC, Davis BM, Dinauer MC, Gerson SL. Selection for gp91phox-transduced murine hematopoietic progenitors by mutant mgmt (P140K) mediated resistance to BG and BCNU using a bicistronic retroviral vector Blood. 96: 385b.  0.92
2000 Jaroscak J, Smith T, Haynesworth S, Laughlin MJ, Kurtzberg J, Gerson SL. Preliminary characterization of the surface staining of placental derived adherent cells: a potential new source of stroma for umbilical cord blood (ucb) expansion Blood. 96.  0.92
2000 Koc ON, Day J, Brown D, Andrews P, Peters C, Nieder M, Gerson SL, Lazarus HM, Caplan AI, Laughlin MJ, Raghavan S, Kolodny EH, Krivit W. Results of a phase i clinical trial of allogeneic mesenchymal stem cell (msc) transplantation in patients with hurlerdisease and metachromaticleukodystrophy (mld) Blood. 96.  0.92
1999 Reese JS, Koç ON, Gerson SL. Human mesenchymal stem cells provide stromal support for efficient CD34+ transduction. Journal of Hematotherapy & Stem Cell Research. 8: 515-23. PMID 10791902 DOI: 10.1089/152581699319966  0.92
1999 Davis BM, Roth JC, Liu L, Xu-Welliver M, Pegg AE, Gerson SL. Characterization of the P140K, PVP(138-140)MLK, and G156A O6-methylguanine-DNA methyltransferase mutants: implications for drug resistance gene therapy. Human Gene Therapy. 10: 2769-78. PMID 10584923 DOI: 10.1089/10430349950016500  0.92
1999 Koç ON, Peters C, Aubourg P, Raghavan S, Dyhouse S, DeGasperi R, Kolodny EH, Yoseph YB, Gerson SL, Lazarus HM, Caplan AI, Watkins PA, Krivit W. Bone marrow-derived mesenchymal stem cells remain host-derived despite successful hematopoietic engraftment after allogeneic transplantation in patients with lysosomal and peroxisomal storage diseases. Experimental Hematology. 27: 1675-81. PMID 10560915 DOI: 10.1016/S0301-472X(99)00101-0  0.92
1999 Liu L, Taverna P, Whitacre CM, Chatterjee S, Gerson SL. Pharmacologic disruption of base excision repair sensitizes mismatch repair-deficient and -proficient colon cancer cells to methylating agents. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 5: 2908-17. PMID 10537360  0.92
1999 Qin X, Zhou H, Liu L, Gerson SL. Transgenic expression of human MGMT blocks the hypersensitivity of PMS2-deficient mice to low dose MNU thymic lymphomagenesis. Carcinogenesis. 20: 1667-73. PMID 10469609 DOI: 10.1093/carcin/20.9.1667  0.92
1999 Phillips WP, Gerson SL. Acquired resistance to O6-benzylguanine plus chloroethylnitrosoureas in human breast cancer. Cancer Chemotherapy and Pharmacology. 44: 319-26. PMID 10447580 DOI: 10.1007/s002800050984  0.92
1999 Qin X, Liu L, Gerson SL. Mice defective in the DNA mismatch gene PMS2 are hypersensitive to MNU induced thymic lymphoma and are partially protected by transgenic expression of human MGMT. Oncogene. 18: 4394-400. PMID 10439048 DOI: 10.1038/sj.onc.1202798  0.92
1999 Koç ON, Reese JS, Szekely EM, Gerson SL. Human long-term culture initiating cells are sensitive to benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea and protected after mutant (G156A) methylguanine methyltransferase gene transfer. Cancer Gene Therapy. 6: 340-8. PMID 10419052 DOI: 10.1038/sj.cgt.7700067  0.92
1999 Allay E, Veigl M, Gerson SL. Mice over-expressing human O6 alkylguanine-DNA alkyltransferase selectively reduce O6 methylguanine mediated carcinogenic mutations to threshold levels after N-methyl-N-nitrosourea. Oncogene. 18: 3783-7. PMID 10391687 DOI: 10.1038/sj.onc.1202697  0.92
1999 Davis BM, Koç ON, Reese JS, Gerson SL. O6-benzylguanine-resistant mutant MGMT genes improve hematopoietic cell tolerance to alkylating agents. Progress in Experimental Tumor Research. 36: 65-81. PMID 10386065  0.92
1999 Spiro TP, Gerson SL, Liu L, Majka S, Haaga J, Hoppel CL, Ingalls ST, Pluda JM, Willson JK. O6-benzylguanine: a clinical trial establishing the biochemical modulatory dose in tumor tissue for alkyltransferase-directed DNA repair. Cancer Research. 59: 2402-10. PMID 10344750  0.92
1999 Koç ON, Reese JS, Davis BM, Liu L, Majczenko KJ, Gerson SL. DeltaMGMT-transduced bone marrow infusion increases tolerance to O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea and allows intensive therapy of 1,3-bis(2-chloroethyl)-1-nitrosourea-resistant human colon cancer xenografts. Human Gene Therapy. 10: 1021-30. PMID 10223735 DOI: 10.1089/10430349950018418  0.92
1999 Gerson SL, Schupp J, Liu L, Pegg AE, Srinivasen S. Leukocyte O6-alkylguanine-DNA alkyltransferase from human donors is uniformly sensitive to O6-benzylguanine. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 5: 521-4. PMID 10100702  0.92
1999 Gerson SL. Mesenchymal stem cells: no longer second class marrow citizens. Nature Medicine. 5: 262-4. PMID 10086373 DOI: 10.1038/6470  0.92
1999 Liu L, Qin X, Gerson SL. Reduced lung tumorigenesis in human methylguanine DNA--methyltransferase transgenic mice achieved by expression of transgene within the target cell. Carcinogenesis. 20: 279-84. PMID 10069465 DOI: 10.1093/carcin/20.2.279  0.92
1999 Dang CV, Gerson SL, Litwak M, Padarathsingh M. Gene therapy and translational cancer research. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 5: 471-4. PMID 10037199  0.92
1999 Reese JS, Davis BM, Liu L, Gerson SL. Simultaneous protection of G156A methylguanine DNA methyltransferase gene-transduced hematopoietic progenitors and sensitization of tumor cells using O6-benzylguanine and temozolomide. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 5: 163-9. PMID 9918215  0.92
1998 Majumdar MK, Thiede MA, Mosca JD, Moorman M, Gerson SL. Phenotypic and functional comparison of cultures of marrow-derived mesenchymal stem cells (MSCs) and stromal cells. Journal of Cellular Physiology. 176: 57-66. PMID 9618145 DOI: 10.1002/(SICI)1097-4652(199807)176:1<57::AID-JCP7>3.0.CO;2-7  0.92
1998 Liu L, Lee K, Schupp J, Koç ON, Gerson SL. Heterogeneity of O6-alkylguanine-DNA-alkyltransferase measured by flow cytometric analysis in blood and bone marrow mononuclear cells. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 4: 475-81. PMID 9516939  0.92
1998 Koç ON, Gerson SL, Phillips GL, Cooper BW, Kutteh L, Van Zant G, Reece DE, Fox RM, Schupp JE, Tainer N, Lazarus HM. Autologous CD34+ cell transplantation for patients with advanced lymphoma: effects of overnight storage on peripheral blood progenitor cell enrichment and engraftment. Bone Marrow Transplantation. 21: 337-43. PMID 9509966 DOI: 10.1038/sj.bmt.1701096  0.92
1997 Raymond E, Izbicka E, Soda H, Gerson SL, Dugan M, Von Hoff DD. Activity of temozolomide against human tumor colony-forming units. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 3: 1769-74. PMID 9815562  0.92
1997 Stefan TL, Ingalls ST, Minkler PE, Willson JK, Gerson SL, Spiro TP, Hoppel CL. Simultaneous determination of O6-benzylguanine and 8-oxo-O6-benzylguanine in human plasma by reversed-phase high-performance liquid chromatography. Journal of Chromatography. B, Biomedical Sciences and Applications. 704: 289-98. PMID 9518162 DOI: 10.1016/S0378-4347(97)00446-5  0.92
1997 Davis BM, Reese JS, Koç ON, Lee K, Schupp JE, Gerson SL. Selection for G156A O6-methylguanine DNA methyltransferase gene-transduced hematopoietic progenitors and protection from lethality in mice treated with O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea. Cancer Research. 57: 5093-9. PMID 9371508  0.92
1997 Lazarus HM, Haynesworth SE, Gerson SL, Caplan AI. Human bone marrow-derived mesenchymal (stromal) progenitor cells (MPCs) cannot be recovered from peripheral blood progenitor cell collections. Journal of Hematotherapy. 6: 447-55. PMID 9368181  0.92
1997 Allay E, Reese JS, McGuire EA, Koç ON, Sedransk N, Gerson SL. Potentiation of lymphomagenesis by methylnitrosourea in mice transgenic for LMO1 is blocked by O6-alkylguanine DNA-alkyltransferase. Oncogene. 15: 2127-32. PMID 9366529 DOI: 10.1038/sj.onc.1201384  0.92
1997 Phillips WP, Willson JK, Markowitz SD, Zborowska E, Zaidi NH, Liu L, Gordon NH, Gerson SL. O6-methylguanine-DNA methyltransferase (MGMT) transfectants of a 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU)-sensitive colon cancer cell line selectively repopulate heterogenous MGMT+/MGMT- xenografts after BCNU and O6-benzylguanine plus BCNU. Cancer Research. 57: 4817-23. PMID 9354444  0.92
1997 Allay JA, Davis BM, Gerson SL. Human alkyltransferase-transduced murine myeloid progenitors are enriched in vivo by BCNU treatment of transplanted mice. Experimental Hematology. 25: 1069-76. PMID 9293904  0.92
1997 Allay JA, Dennis JE, Haynesworth SE, Majumdar MK, Clapp DW, Shultz LD, Caplan AI, Gerson SL. LacZ and interleukin-3 expression in vivo after retroviral transduction of marrow-derived human osteogenic mesenchymal progenitors. Human Gene Therapy. 8: 1417-27. PMID 9287142 DOI: 10.1089/hum.1997.8.12-1417  0.92
1997 Cooper BW, Mackay W, Gerson SL, Lazarus HM. Erythroid burst-forming units (BFU-E) predict hematopoietic recovery after peripheral blood progenitor cell transplantation in patients with advanced breast cancer. Bone Marrow Transplantation. 19: 1089-94. PMID 9193751 DOI: 10.1038/sj.bmt.1700798  0.92
1996 Allay JA, Koç ON, Davis BM, Gerson SL. Retroviral-mediated gene transduction of human alkyltransferase complementary DNA confers nitrosourea resistance to human hematopoietic progenitors. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 2: 1353-9. PMID 9816307  0.92
1996 Smith DC, Gerson SL, Liu L, Donnelly S, Day R, Trump DL, Kirkwood JM. Carmustine and streptozocin in refractory melanoma: an attempt at modulation of O-alkylguanine-DNA-alkyltransferase. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 2: 1129-34. PMID 9816278  0.92
1996 Zaidi NH, Liu L, Gerson SL. Quantitative immunohistochemical estimates of O6-alkylguanine-DNA alkyltransferase expression in normal and malignant human colon. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 2: 577-84. PMID 9816206  0.92
1996 Davis BM, Koc ON, Lee K, Gerson SL. Current progress in the gene therapy of cancer. Current Opinion in Oncology. 8: 499-508. PMID 8971470  0.92
1996 Liu L, Markowitz S, Gerson SL. Mismatch repair mutations override alkyltransferase in conferring resistance to temozolomide but not to 1,3-bis(2-chloroethyl)nitrosourea. Cancer Research. 56: 5375-9. PMID 8968088  0.92
1996 Reese JS, Koç ON, Lee KM, Liu L, Allay JA, Phillips WP, Gerson SL. Retroviral transduction of a mutant methylguanine DNA methyltransferase gene into human CD34 cells confers resistance to O6-benzylguanine plus 1,3-bis(2-chloroethyl)-1-nitrosourea. Proceedings of the National Academy of Sciences of the United States of America. 93: 14088-93. PMID 8943065  0.92
1996 Ross AA, Layton TJ, Ostrander AB, Passos-Coelho JL, Davis JM, Huelskamp AM, Noga SJ, Davidson NE, Kennedy MJ, Cooper BW, Gerson SL, Lazarus HM, Holland K, Gluck S, Moss TJ, et al. Comparative analysis of breast cancer contamination in mobilized and nonmobilized hematopoietic grafts. Journal of Hematotherapy. 5: 549-52. PMID 8938527  0.92
1996 Koç ON, Phillips WP, Lee K, Liu L, Zaidi NH, Allay JA, Gerson SL. Role of DNA repair in resistance to drugs that alkylate O6 of guanine. Cancer Treatment and Research. 87: 123-46. PMID 8886451  0.92
1996 Stefan TL, Ingalls ST, Gerson SL, Willson JK, Hoppel CL. Determination of O6-benzylguanine in human plasma by reversed-phase high-performance liquid chromatography. Journal of Chromatography. B, Biomedical Applications. 681: 331-8. PMID 8811444 DOI: 10.1016/0378-4347(95)00537-4  0.92
1996 Gerson SL, Phillips W, Kastan M, Dumenco LL, Donovan C. Human CD34+ hematopoietic progenitors have low, cytokine-unresponsive O6-alkylguanine-DNA alkyltransferase and are sensitive to O6-benzylguanine plus BCNU. Blood. 88: 1649-55. PMID 8781420  0.92
1996 Roush GR, Rosenthal NS, Gerson SL, Toy EM, McCarthy P, Hirschler NV, Yomtovian R. An unusual case of autoimmune hemolytic anemia with reticulocytopenia, erythroid dysplasia, and an IgG2 autoanti-U. Transfusion. 36: 575-80. PMID 8669092  0.92
1996 Gerson SL. DNA repair and the risk of secondary leukemias. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 14: 681-2. PMID 8636789  0.92
1996 Liu L, Lee K, Wasan E, Gerson SL. Differential sensitivity of human and mouse alkyltransferase to O6-benzylguanine using a transgenic model. Cancer Research. 56: 1880-5. PMID 8620508  0.92
1996 Koç ON, Allay JA, Lee K, Davis BM, Reese JS, Gerson SL. Transfer of drug resistance genes into hematopoietic progenitors to improve chemotherapy tolerance. Seminars in Oncology. 23: 46-65. PMID 8607032  0.92
1996 Lattime EC, Gerson SL. Introduction: genes, oncogenes, and gene therapy strategies for cancer. Seminars in Oncology. 23: 1-3. PMID 8607019  0.92
1996 Winter JN, Lazarus HM, Rademaker A, Villa M, Mangan C, Tallman M, Jahnke L, Gordon L, Newman S, Byrd K, Cooper BW, Horvath N, Crum E, Stadtmauer EA, Conklin E, ... ... Gerson SL, et al. Phase I/II study of combined granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor administration for the mobilization of hematopoietic progenitor cells. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 14: 277-86. PMID 8558209  0.92
1996 Wakazono Y, Kubota M, Furusho K, Liu L, Gerson SL. Thymidine kinase deficient cells with decreased TTP pools are hypersensitive to DNA alkylating agents. Mutation Research. 362: 119-25. PMID 8538643 DOI: 10.1016/0921-8777(95)00042-9  0.92
1995 Gerson SL, Allay E, Vitantonio K, Dumenco LL. Determinants of O6-alkylguanine-DNA alkyltransferase activity in human colon cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 1: 519-25. PMID 9816011  0.92
1995 Lazarus HM, Haynesworth SE, Gerson SL, Rosenthal NS, Caplan AI. Ex vivo expansion and subsequent infusion of human bone marrow-derived stromal progenitor cells (mesenchymal progenitor cells): implications for therapeutic use. Bone Marrow Transplantation. 16: 557-64. PMID 8528172  0.92
1995 Zaidi NH, Allay E, Ayi TC, Li BF, Dumenco LL, Sy MS, Gerson SL. The immature thymocyte is protected from N-methylnitrosourea-induced lymphoma by the human MGMT-CD2 transgene. Carcinogenesis. 16: 1047-53. PMID 7767963 DOI: 10.1093/carcin/16.5.1047  0.92
1995 Allay JA, Dumenco LL, Koc ON, Liu L, Gerson SL. Retroviral transduction and expression of the human alkyltransferase cDNA provides nitrosourea resistance to hematopoietic cells. Blood. 85: 3342-51. PMID 7756667  0.92
1995 Zaidi NH, Pretlow TP, O'Riordan MA, Dumenco LL, Allay E, Gerson SL. Transgenic expression of human MGMT protects against azoxymethane-induced aberrant crypt foci and G to A mutations in the K-ras oncogene of mouse colon. Carcinogenesis. 16: 451-6. PMID 7697797 DOI: 10.1093/carcin/16.3.451  0.92
1995 Willson JK, Haaga JR, Trey JE, Stellato TA, Gordon NH, Gerson SL. Modulation of O6-alkylguanine alkyltransferase-directed DNA repair in metastatic colon cancers. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 13: 2301-8. PMID 7666087  0.92
1995 Gerson SL, Willson JK. O6-alkylguanine-DNA alkyltransferase. A target for the modulation of drug resistance. Hematology/Oncology Clinics of North America. 9: 431-50. PMID 7642472  0.92
1995 Clapp DW, Freie B, Srour E, Yoder MC, Fortney K, Gerson SL. Myeloproliferative sarcoma virus directed expression of beta-galactosidase following retroviral transduction of murine hematopoietic cells. Experimental Hematology. 23: 630-8. PMID 7601255  0.92
1995 Berg SL, Gerson SL, Godwin K, Cole DE, Liu L, Balis FM. Plasma and cerebrospinal fluid pharmacokinetics of O6-benzylguanine and time course of peripheral blood mononuclear cell O6-methylguanine-DNA methyltransferase inhibition in the nonhuman primate. Cancer Research. 55: 4606-10. PMID 7553637  0.92
1995 Mendelowitz AJ, Gerson SL, Alvir JMJ, Lieberman JA. Clozapine-Induced Agranulocytosis: Risk Factors, Monitoring and Management Cns Drugs. 4: 412-421. DOI: 10.2165/00023210-199504060-00004  0.92
1994 Gerson SL, Parker P, Jacobs MR, Creger R, Lazarus HM. Aspergillosis due to carpet contamination. Infection Control and Hospital Epidemiology. 15: 221-3. PMID 8207183 DOI: 10.1086/646896  0.92
1994 Koc ON, McFee M, Reed E, Gerson SL. Detection of platinum-DNA adducts in cord blood lymphocytes following in utero platinum exposure. European Journal of Cancer (Oxford, England : 1990). 30: 716-7. PMID 8080694 DOI: 10.1016/0959-8049(94)90555-X  0.92
1994 Gerson SL, Berger SJ, Varnes ME, Donovan C. Combined depletion of O6-alkylguanine-DNA alkyltransferase and glutathione to modulate nitrosourea resistance in breast cancer. Biochemical Pharmacology. 48: 543-8. PMID 8068041 DOI: 10.1016/0006-2952(94)90284-4  0.92
1994 Liu L, Allay E, Dumenco LL, Gerson SL. Rapid repair of O6-methylguanine-DNA adducts protects transgenic mice from N-methylnitrosourea-induced thymic lymphomas. Cancer Research. 54: 4648-52. PMID 8062258  0.92
1994 Gerson SL, Arce C, Meltzer HY. N-desmethylclozapine: a clozapine metabolite that suppresses haemopoiesis. British Journal of Haematology. 86: 555-61. PMID 8043437  0.92
1994 Frankenburg FR, Stormberg D, Gerson SL. Unsuccessful reexposure to clozapine. Journal of Clinical Psychopharmacology. 14: 428-9. PMID 7884027  0.92
1994 Gerson SL. G-CSF and the management of clozapine-induced agranulocytosis. The Journal of Clinical Psychiatry. 55: 139-42. PMID 7525542  0.92
1994 Gerson SL, Zaidi NH, Dumenco LL, Allay E, Fan CY, Liu L, O'Connor PJ. Alkyltransferase transgenic mice: probes of chemical carcinogenesis. Mutation Research. 307: 541-55. PMID 7514728 DOI: 10.1016/0027-5107(94)90265-8  0.92
1993 Gerson SL. Clozapine--deciphering the risks. The New England Journal of Medicine. 329: 204-5. PMID 8515794 DOI: 10.1056/NEJM199307153290312  0.92
1993 Gerson SL, Zborowska E, Norton K, Gordon NH, Willson JK. Synergistic efficacy of O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) in a human colon cancer xenograft completely resistant to BCNU alone. Biochemical Pharmacology. 45: 483-91. PMID 8435098 DOI: 10.1016/0006-2952(93)90086-C  0.92
1993 Gerson SL. Molecular epidemiology of therapy-related leukemias. Current Opinion in Oncology. 5: 136-44. PMID 8427886  0.92
1993 Dumenco LL, Allay E, Norton K, Gerson SL. The prevention of thymic lymphomas in transgenic mice by human O6-alkylguanine-DNA alkyltransferase. Science (New York, N.Y.). 259: 219-22. PMID 8421782  0.92
1993 Gerson SL, Berger NA. Genetic and molecular approaches to the protection of normal and hematopoietic cells from the nitrosoureas Cancer Bulletin. 45: 125-130.  0.92
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