| Year |
Citation |
Score |
| 2021 |
Smith JN, Dawson DM, Christo KF, Jogasuria AP, Cameron MJ, Antczak MI, Ready JM, Gerson SL, Markowitz SD, Desai AB. 15-PGDH inhibition activates the splenic niche to promote hematopoietic regeneration. Jci Insight. PMID 33600377 DOI: 10.1172/jci.insight.143658 |
0.307 |
|
| 2020 |
Eads JR, Krishnamurthi SS, Saltzman J, Bokar JA, Savvides P, Meropol NJ, Gibbons J, Koon H, Sharma N, Rogers L, Pink JJ, Xu Y, Beumer JH, Riendeau J, Fu P, ... Gerson SL, et al. Phase I clinical trial of temozolomide and methoxyamine (TRC-102), an inhibitor of base excision repair, in patients with advanced solid tumors. Investigational New Drugs. PMID 32556884 DOI: 10.1007/S10637-020-00962-X |
0.333 |
|
| 2020 |
Smith JNP, Otegbeye F, Jogasuria AP, Christo KF, Gerson SL, Markowitz S, Desai AB. Inhibition of 15-PGDH Protects Mice from Immune-mediated Bone Marrow Failure. Biology of Blood and Marrow Transplantation : Journal of the American Society For Blood and Marrow Transplantation. PMID 32422251 DOI: 10.1016/J.Bbmt.2020.04.010 |
0.398 |
|
| 2019 |
Ye R, Kundrapu S, Gerson SL, Driscoll JJ, Beck R, Ali N, Landgren O, VanHeeckeren W, Luo G, Kroger N, Caimi P, De Lima M, Malek E. Immune Signatures Associated With Clonal Isotype Switch After Autologous Stem Cell Transplantation for Multiple Myeloma. Clinical Lymphoma, Myeloma & Leukemia. PMID 30878316 DOI: 10.1016/J.Clml.2018.12.022 |
0.379 |
|
| 2019 |
Srinivasan SS, Seenivasan R, Condie A, Gerson SL, Wang Y, Burda C. Gold Nanoparticle-Based Fluorescent Theranostics for Real-Time Image-Guided Assessment of DNA Damage and Repair. International Journal of Molecular Sciences. 20. PMID 30678294 DOI: 10.3390/Ijms20030471 |
0.305 |
|
| 2019 |
Sloan AE, Roger L, Murphy C, Reese J, Lazarus HM, Dropulic B, Gerson SL. A phase I study of MGMT-P140K transfected hematopoetic progenitor cells (HPC) combined with TMZ/O6BG dose escalation for newly diagnosed, MGMT unmethylated glioblastoma: Tolerance and evidence of survival benefit. Journal of Clinical Oncology. 37: 2062-2062. DOI: 10.1200/Jco.2019.37.15_Suppl.2062 |
0.409 |
|
| 2018 |
Hashemi Sadraei N, Feng Y, Du L, Fu P, Haque S, Dowlati A, Gollamudi J, Pennell NA, Mekhail T, Avril S, Farver C, Gerson SL, Sharma N. High UDG and BRCA1 expression is associated with adverse outcome in patients with pemetrexed treated non-small cell lung Cancer. Lung Cancer (Amsterdam, Netherlands). 126: 48-54. PMID 30527192 DOI: 10.1016/J.Lungcan.2018.08.011 |
0.349 |
|
| 2018 |
Desai A, Yan Y, Gerson SL. Concise Reviews: Cancer Stem Cell Targeted Therapies: Toward Clinical Success. Stem Cells Translational Medicine. PMID 30328686 DOI: 10.1002/Sctm.18-0123 |
0.41 |
|
| 2018 |
Patel R, Zhang L, Desai A, Hoenerhoff MJ, Kennedy LH, Radivoyevitch T, Ban Y, Chen XS, Gerson SL, Welford SM. Mlh1 deficiency increases the risk of hematopoietic malignancy after simulated space radiation exposure. Leukemia. PMID 30275527 DOI: 10.1038/S41375-018-0269-8 |
0.326 |
|
| 2018 |
Desai A, Yan Y, Gerson SL. Advances in therapeutic targeting of the DNA damage response in cancer. Dna Repair. 66: 24-29. PMID 29715575 DOI: 10.1016/J.Dnarep.2018.04.004 |
0.339 |
|
| 2018 |
Patel R, Qing Y, Kennedy L, Yan Y, Pink J, Aguila B, Desai A, Gerson SL, Welford SM. MMR Deficiency Does Not Sensitize or Compromise the Function of Hematopoietic Stem Cells to Low and High LET Radiation. Stem Cells Translational Medicine. PMID 29656536 DOI: 10.1002/Sctm.17-0295 |
0.323 |
|
| 2018 |
Desai A, Zhang Y, Park Y, Dawson DM, Larusch GA, Kasturi L, Wald D, Ready JM, Gerson SL, Markowitz SD. A second-generation 15-PGDH inhibitor promotes bone marrow transplant recovery independent of age, transplant dose, and G-CSF support. Haematologica. PMID 29472361 DOI: 10.3324/Haematol.2017.178376 |
0.364 |
|
| 2018 |
William BM, Brillhart K, Afable M, Bakalarz K, Cooper B, Lazarus HM, Gerson SL, Creger R, Nagabhushanam K, Grote J, Fu P, Kunati S, Yang S, Xu Y, Woost P, et al. A Phase II Study of Curcumin and Vitamin D in Previously Untreated Patients with Early Stage Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL) Blood. 132: 1875-1875. DOI: 10.1182/Blood-2018-99-112295 |
0.324 |
|
| 2018 |
Nguyen MT, Yan Y, Fedorvo Y, Pink J, Adams D, Gerson S. Abstract 1663: Identification and characterization of a small-molecule inhibitor of the human uracil-DNA glycosylase for use in combination with DNA damage-based anticancer therapies Cancer Research. 78: 1663-1663. DOI: 10.1158/1538-7445.Am2018-1663 |
0.348 |
|
| 2017 |
Ramos EK, Hoffmann AD, Gerson SL, Liu H. New Opportunities and Challenges to Defeat Cancer Stem Cells. Trends in Cancer. 3: 780-796. PMID 29120754 DOI: 10.1016/J.Trecan.2017.08.007 |
0.362 |
|
| 2017 |
Yan Y, Qing Y, Pink JJ, Gerson SL. Loss of Uracil DNA Glycosylase Selectively Re-sensitizes p53 Mutant and Deficient Cells to 5-FdU. Molecular Cancer Research : McR. PMID 29117941 DOI: 10.1158/1541-7786.Mcr-17-0215 |
0.357 |
|
| 2017 |
Dashzeveg NK, Taftaf R, Ramos EK, Torre-Healy L, Chumakova A, Silver DJ, Alban TJ, Sinyuk M, Thiagarajan PS, Jarrar AM, Turaga SM, Saygin C, Mulkearns-Hubert E, Hitomi M, Rich JN, ... Gerson SL, et al. New Advances and Challenges of Targeting Cancer Stem Cells. Cancer Research. PMID 28928129 DOI: 10.1158/0008-5472.Can-17-0054 |
0.37 |
|
| 2017 |
Qing Y, Gerson SL. Mismatch repair deficient hematopoietic stem cells are preleukemic stem cells. Plos One. 12: e0182175. PMID 28767666 DOI: 10.1371/Journal.Pone.0182175 |
0.436 |
|
| 2017 |
Shi H, Zhang C, Pasupuleti V, Hu X, Prosdocimo DA, Wu W, Qing Y, Wu S, Mohammad H, Gerson SL, Perbal B, Klenotic PA, Dong N, Lin Z. CCN3 Regulates Macrophage Foam Cell Formation and Atherosclerosis. The American Journal of Pathology. 187: 1230-1237. PMID 28527710 DOI: 10.1016/J.Ajpath.2017.01.020 |
0.328 |
|
| 2017 |
Cohen JA, Imrey PB, Planchon SM, Bermel RA, Fisher E, Fox RJ, Bar-Or A, Sharp SL, Skaramagas TT, Jagodnik P, Karafa M, Morrison S, Reese Koc J, Gerson SL, Lazarus HM. Pilot trial of intravenous autologous culture-expanded mesenchymal stem cell transplantation in multiple sclerosis. Multiple Sclerosis (Houndmills, Basingstoke, England). 1352458517703802. PMID 28381130 DOI: 10.1177/1352458517703802 |
0.364 |
|
| 2017 |
Tacastacas JD, Chan DV, Carlson S, Gerson SL, Dowlati A, Fu P, Lu K, Groft S, Rosenjack J, Honda K, McCormick T, Cooper KD. Evaluation of O6-Benzylguanine-Potentiated Topical Carmustine for Mycosis Fungoides: A Phase 1-2 Clinical Trial. Jama Dermatology. PMID 28199478 DOI: 10.1001/Jamadermatol.2016.5793 |
0.306 |
|
| 2016 |
Massoud MR, Caimi PF, Ferrari N, Fu P, Creger R, Fox R, Carlson-Barko J, Kolk M, Brister L, Cooper BW, Gerson S, Lazarus HM, de Lima M, William BM. Outcomes of allogeneic hematopoietic stem cell transplantation for lymphomas: a single-institution experience. Revista Brasileira De Hematologia E Hemoterapia. 38: 314-319. PMID 27863759 DOI: 10.1016/J.Bjhh.2016.07.003 |
0.34 |
|
| 2016 |
Oleinick NL, Biswas T, Patel R, Tao M, Patel R, Weeks L, Sharma N, Dowlati A, Gerson SL, Fu P, Zhang J, Machtay M. Radiosensitization of non-small-cell lung cancer cells and xenografts by the interactive effects of pemetrexed and methoxyamine. Radiotherapy and Oncology : Journal of the European Society For Therapeutic Radiology and Oncology. PMID 27838149 DOI: 10.1016/J.Radonc.2016.10.007 |
0.332 |
|
| 2016 |
Kenyon J, Nickel-Meester G, Qing Y, Santos-Guasch G, Drake E, PingfuFu, Sun S, Bai X, Wald D, Arts E, Gerson SL. Epigenetic Loss of MLH1 Expression in Normal Human Hematopoietic Stem Cell Clones is Defined by the Promoter CpG Methylation Pattern Observed by High-Throughput Methylation Specific Sequencing. International Journal of Stem Cell Research and Therapy. 3. PMID 27570841 DOI: 10.23937/2469-570X/1410031 |
0.373 |
|
| 2016 |
Yan Y, Han X, Qing Y, Condie AG, Gorityala S, Yang S, Xu Y, Zhang Y, Gerson SL. Inhibition of uracil DNA glycosylase sensitizes cancer cells to 5-fluorodeoxyuridine through replication fork collapse-induced DNA damage. Oncotarget. PMID 27517750 DOI: 10.18632/Oncotarget.11151 |
0.382 |
|
| 2016 |
Patel R, Welford S, Gerson SL. The Effects of Galactic Cosmic Radiation Exposure on Hematopoietic Stem Cell Dysfunction and Oncogenesis Blood. 128: 5297-5297. DOI: 10.1182/Blood.V128.22.5297.5297 |
0.371 |
|
| 2016 |
Sloan A, Fung H, Reese-Kroc J, Rogers L, Murphy C, Lazrus H, Dropulic B, Gerson S. ACTR-54. PHASE I TRIAL OF GENETICALLY MODIFIED HEMATOPOETIC PROGENITOR CELLS FACILITATING BONE MARROW CHEMOPROTECTION AND ENABLING TMZ/O6BG DOSE ESCALATION RESULTING IN IMPROVED SURVIVAL Neuro-Oncology. 18: vi14-vi14. DOI: 10.1093/Neuonc/Now212.052 |
0.333 |
|
| 2015 |
Chakrabarti G, Silvers MA, Ilcheva M, Liu Y, Moore ZR, Luo X, Gao J, Anderson G, Liu L, Sarode V, Gerber DE, Burma S, DeBerardinis RJ, Gerson SL, Boothman DA. Tumor-selective use of DNA base excision repair inhibition in pancreatic cancer using the NQO1 bioactivatable drug, β-lapachone. Scientific Reports. 5: 17066. PMID 26602448 DOI: 10.1038/Srep17066 |
0.376 |
|
| 2015 |
Condie AG, Yan Y, Gerson SL, Wang Y. A Fluorescent Probe to Measure DNA Damage and Repair. Plos One. 10: e0131330. PMID 26309022 DOI: 10.1371/Journal.Pone.0131330 |
0.33 |
|
| 2015 |
Caimi PF, William BM, Silva Rondon CH, Fu P, Cooper BW, Campagnaro EL, Gerson SL, Reese-Koc J, Fox R, Creger RJ, de Lima M, Lazarus HM. Comparison of 2 Carmustine-Containing Regimens in the Rituximab Era: Excellent Outcomes Even in Poor-Risk Patients. Biology of Blood and Marrow Transplantation : Journal of the American Society For Blood and Marrow Transplantation. 21: 1926-31. PMID 26087475 DOI: 10.1016/J.Bbmt.2015.06.007 |
0.314 |
|
| 2015 |
Zhang Y, Desai A, Yang SY, Bae KB, Antczak MI, Fink SP, Tiwari S, Willis JE, Williams NS, Dawson DM, Wald D, Chen WD, Wang Z, Kasturi L, Larusch GA, ... ... Gerson SL, et al. TISSUE REGENERATION. Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration. Science (New York, N.Y.). 348: aaa2340. PMID 26068857 DOI: 10.1126/Science.Aaa2340 |
0.317 |
|
| 2015 |
Afable M, Caimi PF, Hosing C, de Lima M, Khouri I, William BM, Nieto Y, Cooper BW, Anderlini P, Gerson SL, Lazarus HM, Champlin R, Popat U. Hematopoietic Progenitor Cell Harvesting Is Feasible after Treatment with Brentuximab Vedotin in CD30(+) Lymphoma Patients Who Received Multiple Prior Lines of Treatment. Biology of Blood and Marrow Transplantation : Journal of the American Society For Blood and Marrow Transplantation. 21: 1529-31. PMID 25937397 DOI: 10.1016/J.Bbmt.2015.04.022 |
0.385 |
|
| 2015 |
Adorno-Cruz V, Kibria G, Liu X, Doherty M, Junk DJ, Guan D, Hubert C, Venere M, Mulkearns-Hubert E, Sinyuk M, Alvarado A, Caplan AI, Rich J, Gerson SL, Lathia J, et al. Cancer stem cells: targeting the roots of cancer, seeds of metastasis, and sources of therapy resistance. Cancer Research. 75: 924-9. PMID 25604264 DOI: 10.1158/0008-5472.Can-14-3225 |
0.353 |
|
| 2015 |
Roth JC, Alberti MO, Ismail M, Lingas KT, Reese JS, Gerson SL. MGMT enrichment and second gene co-expression in hematopoietic progenitor cells using separate or dual-gene lentiviral vectors. Virus Research. 196: 170-80. PMID 25479595 DOI: 10.1016/J.Virusres.2014.11.027 |
0.729 |
|
| 2015 |
Ueda M, Caimi PF, Stefan T, Lazarus HM, Cooper B, de Lima M, Gerson SL, Wald DN. Glycogen Synthase Kinase-3 (GSK3) Inhibition with Lithium in Combination with Tretinoin Induces Differentiation in Non-Promyelocytic Acute Myeloid Leukemia (AML) Blood. 126: 1360-1360. DOI: 10.1182/Blood.V126.23.1360.1360 |
0.39 |
|
| 2015 |
Condie AG, Yan Y, Gerson SL, Wang Y. Abstract 4754: Development of fluorescent probes for detection of DNA base excision repair in human cancer cells Cancer Research. 75: 4754-4754. DOI: 10.1158/1538-7445.Am2015-4754 |
0.347 |
|
| 2015 |
Yan Y, Condie A, Gerson S. Abstract 3854: Inhibition of uracil DNA glycosylase (UDG) sensitizes cancer cells to thymidylate synthase inhibitors Cancer Research. 75: 3854-3854. DOI: 10.1158/1538-7445.Am2015-3854 |
0.4 |
|
| 2014 |
Desai A, Gerson S. Exo1 independent DNA mismatch repair involves multiple compensatory nucleases. Dna Repair. 21: 55-64. PMID 25037770 DOI: 10.1016/J.Dnarep.2014.06.005 |
0.427 |
|
| 2014 |
Weeks LD, Zentner GE, Scacheri PC, Gerson SL. Uracil DNA glycosylase (UNG) loss enhances DNA double strand break formation in human cancer cells exposed to pemetrexed. Cell Death & Disease. 5: e1045. PMID 24503537 DOI: 10.1038/Cddis.2013.477 |
0.4 |
|
| 2014 |
Desai A, Webb B, Gerson SL. CD133+ cells contribute to radioresistance via altered regulation of DNA repair genes in human lung cancer cells. Radiotherapy and Oncology : Journal of the European Society For Therapeutic Radiology and Oncology. 110: 538-45. PMID 24440048 DOI: 10.1016/J.Radonc.2013.10.040 |
0.401 |
|
| 2014 |
Desai A, Qing Y, Gerson SL. Exonuclease 1 is a critical mediator of survival during DNA double strand break repair in nonquiescent hematopoietic stem and progenitor cells. Stem Cells (Dayton, Ohio). 32: 582-93. PMID 24420907 DOI: 10.1002/Stem.1596 |
0.426 |
|
| 2014 |
Qing Y, Wang Z, Bunting KD, Gerson SL. Bcl2 overexpression rescues the hematopoietic stem cell defects in Ku70-deficient mice by restoration of quiescence. Blood. 123: 1002-11. PMID 24394664 DOI: 10.1182/Blood-2013-08-521716 |
0.369 |
|
| 2014 |
Ravi G, Cooper B, Campagnaro EL, William BM, Creger RJ, Gerson SL, De Lima M, Lazarus HM, Caimi P. Increased Risk of Venous Thromboembolism in Primary Central Nervous System Lymphoma Patients Undergoing Therapy Blood. 124: 5431-5431. DOI: 10.1182/Blood.V124.21.5431.5431 |
0.307 |
|
| 2014 |
Caimi P, Gupta K, Stefan T, Cooper B, William BM, Campagnaro EL, Creger RJ, Kane D, Gerson SL, Lazarus HM, de Lima M, Wald DN. All-Trans-Retinoic Acid (ATRA) Combined with Lithium As Treatment of Relapsed Non-Progranulocytic AML: Therapeutic Targeting Inhibition of the Glycogen Synthase Kinase 3-Beta (GSK3) Enzyme Blood. 124: 5299-5299. DOI: 10.1182/Blood.V124.21.5299.5299 |
0.366 |
|
| 2014 |
Fung H, Sloan AE, Reese J, William BM, Lingas K, Rogers LR, Embree H, Lazarus HM, Kane D, Dropulic B, Gerson SL. Viral Insertion Safety in Patients with Glioblastoma Who Received a Novel Lentiviral MGMT-P140K Gene Therapy to Protect Bone Marrow from Chemotherapy: No Dominant Clonal Evolution Observed with Chemo-Selection Blood. 124: 4801-4801. DOI: 10.1182/Blood.V124.21.4801.4801 |
0.43 |
|
| 2014 |
Caimi P, Cooper B, William BM, Campagnaro EL, Creger RJ, Afable M, Xu Y, Pink J, Dowlati A, Lazarus HM, de Lima M, Gerson SL. Phase I Trial of the Base – Excision Repair Blocker Methoxyamine (TRC-102) Combined with Fludarabine in Relapsed/Refractory Chronic Lymphocytic Leukemia (CLL) and Lymphoid Malignancies Blood. 124: 4688-4688. DOI: 10.1182/Blood.V124.21.4688.4688 |
0.371 |
|
| 2014 |
Afable M, Caimi PF, Hosing C, de Lima M, Khouri IF, William BM, Nieto Y, Cooper BW, Anderlini P, Campagnaro EL, Gerson SL, Lazarus HM, Champlin RE, Popat UR. Brentuximab Vedotin (BV) Does Not Impair Autologous Peripheral Blood Stem Cell Mobilization and Collection in Refractory/Relapsed CD30+ Lymphoma Patients Undergoing High-Dose Chemotherapy and Autologous Stem Cell Transplant (HDC-ASCT) Blood. 124: 3854-3854. DOI: 10.1182/Blood.V124.21.3854.3854 |
0.384 |
|
| 2014 |
Metheny L, Lima Md, Gerson S, Eid S, Huang AY. Intra-Osseous Co-Transplantation of CD34-Selected Umbilical Cord Blood and Mesenchymal Stromal Cells Blood. 124: 3811-3811. DOI: 10.1182/Blood.V124.21.3811.3811 |
0.331 |
|
| 2014 |
Qing Y, Gerson SL. Abstract 1910: Evolution of preleukemia stem cells to lymphoma initiating cells requires thymus in msh2-/- mice Cancer Research. 74: 1910-1910. DOI: 10.1158/1538-7445.Am2014-1910 |
0.429 |
|
| 2013 |
Weeks LD, Fu P, Gerson SL. Uracil-DNA glycosylase expression determines human lung cancer cell sensitivity to pemetrexed. Molecular Cancer Therapeutics. 12: 2248-60. PMID 23873851 DOI: 10.1158/1535-7163.Mct-13-0172 |
0.413 |
|
| 2013 |
Corn DJ, Kim Y, Krebs MD, Mounts T, Molter J, Gerson S, Alsberg E, Dennis JE, Lee Z. Imaging early stage osteogenic differentiation of mesenchymal stem cells. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 31: 871-9. PMID 23440976 DOI: 10.1002/Jor.22328 |
0.39 |
|
| 2013 |
Yu WM, Liu X, Shen J, Jovanovic O, Pohl EE, Gerson SL, Finkel T, Broxmeyer HE, Qu CK. Metabolic regulation by the mitochondrial phosphatase PTPMT1 is required for hematopoietic stem cell differentiation. Cell Stem Cell. 12: 62-74. PMID 23290137 DOI: 10.1016/J.Stem.2012.11.022 |
0.322 |
|
| 2013 |
Gordon MS, Rosen LS, Mendelson D, Ramanathan RK, Goldman J, Liu L, Xu Y, Gerson SL, Anthony SP, Figg WD, Spencer S, Adams BJ, Theuer CP, Leigh BR, Weiss GJ. A phase 1 study of TRC102, an inhibitor of base excision repair, and pemetrexed in patients with advanced solid tumors. Investigational New Drugs. 31: 714-23. PMID 23054206 DOI: 10.1007/S10637-012-9876-9 |
0.331 |
|
| 2013 |
Weeks LD, Fu P, Liu L, Gerson SL. Abstract 4484: Uracil DNA glycosylase expression determines human lung cancer cell sensitivity to pemetrexed. Cancer Research. 73: 4484-4484. DOI: 10.1158/1538-7445.Am2013-4484 |
0.396 |
|
| 2013 |
Weeks LD, Zentner G, Scacheri P, Gerson SL. Abstract 4482: Pemetrexed treatment results in DNA replication fork instability and double strand breaks formation in UNG-/- human cancer cells. Cancer Research. 73: 4482-4482. DOI: 10.1158/1538-7445.Am2013-4482 |
0.401 |
|
| 2013 |
Luo X, Li L, Huang X, Cao L, Moore Z, Deberardinis R, Brekken R, Gerson S, Liu L, Boothman DA. Abstract 3344: Inhibiting base excision repair synergistically enhances beta-lapachone-mediated ‘kiss of death’ for tumor-selective therapy of pancreatic cancer. Cancer Research. 73: 3344-3344. DOI: 10.1158/1538-7445.Am2013-3344 |
0.339 |
|
| 2013 |
Fung H, Gerson SL, Barbas CF. Abstract 3332: An artificial zinc finger glycosylase causes site-directed DNA damages and specifically kills the targeted cancer cells via synthetic lethality. Cancer Research. 73: 3332-3332. DOI: 10.1158/1538-7445.Am2013-3332 |
0.36 |
|
| 2013 |
Wang Y, Wu C, Condie A, Zhu J, Gerson S. Abstract B141: Molecular imaging of DNA damage and repair in cancer. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-B141 |
0.346 |
|
| 2013 |
Biswas T, Patel R, Weeks L, Patel R, Dowlati A, Sharma N, Oleinick N, Gerson S, Machtay M. Enhanced Radiosensitization of Lung Adenocarcinoma Cells by Pemetrexed When Combined With Methoxyamine to Inhibit Base Excision Repair International Journal of Radiation Oncology*Biology*Physics. 87: S662. DOI: 10.1016/J.Ijrobp.2013.06.1754 |
0.422 |
|
| 2012 |
Roth JC, Ismail M, Reese JS, Lingas KT, Ferrari G, Gerson SL. Cotransduction with MGMT and Ubiquitous or Erythroid-Specific GFP Lentiviruses Allows Enrichment of Dual-Positive Hematopoietic Progenitor Cells In Vivo. Isrn Hematology. 2012: 212586. PMID 22888445 DOI: 10.5402/2012/212586 |
0.743 |
|
| 2012 |
Falahati R, Zhang J, Flebbe-Rehwaldt L, Shi Y, Gerson SL, Gaensler KM. Chemoselection of allogeneic HSC after murine neonatal transplantation without myeloablation or post-transplant immunosuppression. Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 2180-9. PMID 22871662 DOI: 10.1038/Mt.2012.136 |
0.395 |
|
| 2012 |
Kenyon J, Fu P, Lingas K, Thomas E, Saurastri A, Santos Guasch G, Wald D, Gerson SL. Humans accumulate microsatellite instability with acquired loss of MLH1 protein in hematopoietic stem and progenitor cells as a function of age. Blood. 120: 3229-36. PMID 22740444 DOI: 10.1182/Blood-2011-12-401950 |
0.381 |
|
| 2012 |
Alberti MO, Roth JC, Ismail M, Tsuruta Y, Abraham E, Pereboeva L, Gerson SL, Curiel DT. Derivation of a myeloid cell-binding adenovirus for gene therapy of inflammation. Plos One. 7: e37812. PMID 22624065 DOI: 10.1371/Journal.Pone.0037812 |
0.713 |
|
| 2012 |
Fontes AM, Melo FU, Greene LJ, Faça VM, Lin Y, Gerson SL, Covas DT. Production of human factor VIII-FL in 293T cells using the bicistronic MGMT(P140K)-retroviral vector. Genetics and Molecular Research : Gmr. 11: 775-89. PMID 22576836 DOI: 10.4238/2012.March.22.8 |
0.362 |
|
| 2012 |
Apisarnthanarax N, Wood GS, Stevens SR, Carlson S, Chan DV, Liu L, Szabo SK, Fu P, Gilliam AC, Gerson SL, Remick SC, Cooper KD. Phase I clinical trial of O6-benzylguanine and topical carmustine in the treatment of cutaneous T-cell lymphoma, mycosis fungoides type. Archives of Dermatology. 148: 613-20. PMID 22250189 DOI: 10.1001/Archdermatol.2011.2797 |
0.333 |
|
| 2012 |
Bulgar AD, Weeks LD, Miao Y, Yang S, Xu Y, Guo C, Markowitz S, Oleinick N, Gerson SL, Liu L. Removal of uracil by uracil DNA glycosylase limits pemetrexed cytotoxicity: overriding the limit with methoxyamine to inhibit base excision repair. Cell Death & Disease. 3: e252. PMID 22237209 DOI: 10.1038/Cddis.2011.135 |
0.414 |
|
| 2012 |
Qing Y, Lin Y, Gerson SL. An intrinsic BM hematopoietic niche occupancy defect of HSC in scid mice facilitates exogenous HSC engraftment. Blood. 119: 1768-71. PMID 22147896 DOI: 10.1182/Blood-2011-05-350611 |
0.372 |
|
| 2012 |
Cohen J, Bar-Or A, Bermel R, Fisher E, Fox R, Gerson S, Imrey P, Lazarus H, Planchon S, Reese J, Schwanger C, Skaramagas T. Phase 1 Clinical Trial of Autologous Mesenchymal Stem Cell Transplantation in Multiple Sclerosis (S30.002) Neurology. 78: S30.002-S30.002. DOI: 10.1212/Wnl.78.1_Meetingabstracts.S30.002 |
0.364 |
|
| 2012 |
Sloan AE, Reese J, Rogers LR, Lo SS, Nock CJ, Lazarus HM, Machtay M, Fu P, Fung H, Embree H, Dropulic B, Gerson S. O6-benzylguanine (BG) and temozolomide (TMZ) therapy of glioblastoma multiforme (GBM) with infusion of autologous lentiviral transduced P140KMGMT+ hematopoietic progenitors to protect hematopoiesis: A phase I study. Journal of Clinical Oncology. 30. DOI: 10.1200/Jco.2012.30.15_Suppl.Tps1616 |
0.402 |
|
| 2012 |
Yu W, Liu X, Shen J, Jovanovic O, Pohl EE, Gerson SL, Finkel T, Broxmeyer HE, Qu C. Disruption of Mitochondrial Phosphatase Ptpmt1 Induces Bioenergetic Stress and Differentiation Block in Hematopoietic Stem Cells Blood. 120: 857-857. DOI: 10.1182/Blood.V120.21.857.857 |
0.389 |
|
| 2012 |
Qing Y, Wang Z, Matsuyama S, Bunting KD, Gerson SL. Rescue of the HSC Maintenance Defects in Ku70-Deficient Mice by Overexpression of Bcl2 Reveals a Novel Role of Bcl2 in HSC Blood. 120: 1235-1235. DOI: 10.1182/Blood.V120.21.1235.1235 |
0.322 |
|
| 2012 |
Desai A, Gerson SL, Qing Y. Hematopoietic Stem Cells Are Dependent On Homologous Recombination Only During Active Cell Cycle in Nuclease-Mutant Exonuclease1mut mice Blood. 120: 1225-1225. DOI: 10.1182/Blood.V120.21.1225.1225 |
0.407 |
|
| 2012 |
Savvides PS, Xu Y, Liu L, Rogers L, Krishnamurthi S, Dowlati A, Gerson SL. Abstract 753: Pharmacokinetic profile of the base-excision repair inhibitor methoxyamine-HCl (TRC102; MX) given as an one-hour intravenous infusion with temozolomide (TMZ) in the first in human phase 1 clinical trial Cancer Research. 72: 753-753. DOI: 10.1158/1538-7445.Am2012-753 |
0.326 |
|
| 2012 |
Weeks LD, Gerson SL, Liu L. Abstract 4696: Expression of the DNA repair protein UNG predicts lung cancer sensitivity to pemetrexed Cancer Research. 72: 4696-4696. DOI: 10.1158/1538-7445.Am2012-4696 |
0.368 |
|
| 2012 |
Savvides PS, Xu Y, Liu L, Rogers L, Bokar J, Silverman P, Dowlati A, Gerson SL. Abstract 1743: Phase 1 clinical trial of the base-excision repair inhibitor Methoxyamine-HCl (TRC102; MX) in combination with Temozolomide (TMZ) in patients with solid tumors Cancer Research. 72: 1743-1743. DOI: 10.1158/1538-7445.Am2012-1743 |
0.351 |
|
| 2011 |
Xu D, Liu X, Yu WM, Meyerson HJ, Guo C, Gerson SL, Qu CK. Non-lineage/stage-restricted effects of a gain-of-function mutation in tyrosine phosphatase Ptpn11 (Shp2) on malignant transformation of hematopoietic cells. The Journal of Experimental Medicine. 208: 1977-88. PMID 21930766 DOI: 10.1084/Jem.20110450 |
0.317 |
|
| 2011 |
Yao D, Huang Y, Huang X, Wang W, Yan Q, Wei L, Xin W, Gerson S, Stanley P, Lowe JB, Zhou L. Protein O-fucosyltransferase 1 (Pofut1) regulates lymphoid and myeloid homeostasis through modulation of Notch receptor ligand interactions. Blood. 117: 5652-62. PMID 21464368 DOI: 10.1182/Blood-2010-12-326074 |
0.303 |
|
| 2011 |
Lazarus HM, Sommers SR, Arfons LM, Fu P, Ataergin SA, Kaye NM, Liu F, Kindwall-Keller TL, Cooper BW, Laughlin MJ, Creger RJ, Barr PM, Gerson SL, Kaplan D. Spontaneous autologous graft-versus-host disease in plasma cell myeloma autograft recipients: flow cytometric analysis of hematopoietic progenitor cell grafts. Biology of Blood and Marrow Transplantation : Journal of the American Society For Blood and Marrow Transplantation. 17: 970-8. PMID 21440080 DOI: 10.1016/J.Bbmt.2011.03.005 |
0.413 |
|
| 2011 |
Lin Y, Cheung P, Roth JC, Wilson DL, Gerson SL. Imaging stem cell-derived persistent foci after in vivo selection of lentiviral MGMT-P140K transduced murine bone marrow cells. Molecular Therapy : the Journal of the American Society of Gene Therapy. 19: 1342-52. PMID 21304493 DOI: 10.1038/Mt.2010.315 |
0.748 |
|
| 2011 |
Qing Y, Reese J, Liu M, Desai A, Embree H, Dropulic B, Gerson SL. Regulatory-Approval Driven Safety and Efficacy of MGMTP140K Lentivirus Transduction of Human CD34+ Cells for a Phase I Clinical Trial for Upfront Treatment of Glioma, Blood. 118: 4177-4177. DOI: 10.1182/Blood.V118.21.4177.4177 |
0.47 |
|
| 2011 |
Xu D, Liu X, Yu W, Meyerson HJ, Gerson SL, Qu C. Non-Lineage/Stage Restricted Effects of a Gain-of-Function Mutation in Tyrosine Phosphatase Ptpn11 (Shp2) on Malignant Transformation of Hematopoietic Cells Blood. 118: 392-392. DOI: 10.1182/Blood.V118.21.392.392 |
0.317 |
|
| 2011 |
Desai A, Qing Y, Gerson SL. Characterization of Hematopoietic Stem Cell Function and Sensitivity in the Homologous Recombination Deficient Exonuclease1mut Mouse Model Blood. 118: 1293-1293. DOI: 10.1182/Blood.V118.21.1293.1293 |
0.419 |
|
| 2011 |
Weeks LD, Liu M, Liu L, Gerson SL. Abstract 5490: Mice deficient in uracil DNA glycosylase (UDG) display increased sensitivity to the antifolate pemetrexed Cancer Research. 71: 5490-5490. DOI: 10.1158/1538-7445.Am2011-5490 |
0.42 |
|
| 2011 |
Li L, Xu Y, Liu L, Gerson SL. Abstract 5454: Drug effect analysis of methoxyamine through quantifying the drug on its therapeutic target Cancer Research. 71: 5454-5454. DOI: 10.1158/1538-7445.Am2011-5454 |
0.33 |
|
| 2011 |
Bulgar A, Weeks LD, Miao Y, Yang S, Xu Y, Guo C, Markowitz S, Gerson SL, Liu L. Abstract A104: Removal of uracil by uracil DNA glycosylase limits pemetrexed cytotoxicity: Overriding the limit with methoxyamine (TRC102) to inhibit base excision repair. Molecular Cancer Therapeutics. 10. DOI: 10.1158/1535-7163.Targ-11-A104 |
0.415 |
|
| 2011 |
Weeks LD, Zetner G, Scacheri P, Liu L, Gerson SL. Abstract A100: Pemetrexed-induced uracil accumulation is an importatn source of DNA damage in UNG deficient cells, contributing to hematologic toxicity. Molecular Cancer Therapeutics. 10. DOI: 10.1158/1535-7163.Targ-11-A100 |
0.457 |
|
| 2010 |
Kundu S, Fan K, Cao M, Lindner DJ, Tuthill R, Liu L, Gerson S, Borden E, Yi T. Tyrosine phosphatase inhibitor-3 sensitizes melanoma and colon cancer to biotherapeutics and chemotherapeutics. Molecular Cancer Therapeutics. 9: 2287-96. PMID 20682647 DOI: 10.1158/1535-7163.Mct-10-0159 |
0.388 |
|
| 2010 |
Rizzieri D, LoRusso S, Tse W, Khan K, Advani A, Moore J, Karsten V, Cahill A, Gerson SL. Phase I study of temozolomide and laromustine (VNP40101M) in patients with relapsed or refractory leukemia. Clinical Lymphoma, Myeloma & Leukemia. 10: 211-6. PMID 20511167 DOI: 10.3816/Clml.2010.N.033 |
0.355 |
|
| 2010 |
Yan Q, Yao D, Wei LL, Huang Y, Myers J, Zhang L, Xin W, Shim J, Man Y, Petryniak B, Gerson S, Lowe JB, Zhou L. O-fucose modulates Notch-controlled blood lineage commitment. The American Journal of Pathology. 176: 2921-34. PMID 20363915 DOI: 10.2353/Ajpath.2010.090702 |
0.41 |
|
| 2010 |
Sawides P, Xu Y, Liu L, Bokar JA, Silverman P, Dowlati A, Gerson SL. Pharmacokinetic profile of the base-excision repair inhibitor methoxyamine-HCl (TRC102; MX) given as an one-hour intravenous infusion with temozolomide (TMZ) in the first-in-human phase I clinical trial. Journal of Clinical Oncology. 28: e13662-e13662. DOI: 10.1200/Jco.2010.28.15_Suppl.E13662 |
0.328 |
|
| 2010 |
Qing Y, Lin Y, Park Y, Gerson SL. Self-Renewal and BM Niche Occupancy Defects In NHEJ Deficient HSCs. Blood. 116: 1455-1455. DOI: 10.1182/Blood.V116.21.1455.1455 |
0.424 |
|
| 2010 |
Wang Y, Liu L, Wu C, Bulgar A, Zhu W, Somoza E, Gerson S. Abstract LB-138:In vivoimaging of DNA damage and repair Cancer Research. 70. DOI: 10.1158/1538-7445.Am10-Lb-138 |
0.344 |
|
| 2010 |
Bulgar AD, Miao Y, Gerson SL, Liu L. Abstract 682: Dual inhibition of BER by TRC102 and PARP inhibitor (ABT 888) synergistically enhances cytotoxicity of TMZ in human melanoma Cancer Research. 70: 682-682. DOI: 10.1158/1538-7445.Am10-682 |
0.395 |
|
| 2010 |
Weeks LD, Liu L, Gerson SL. Abstract 2984: Association of the Uracil DNA glycosylase (UNG) promoter in human lung cancer cells with the transcription factor family E2F is lost after pemetrexed treatment Cancer Research. 70: 2984-2984. DOI: 10.1158/1538-7445.Am10-2984 |
0.392 |
|
| 2009 |
Anthony SP, Rosen LS, Weiss GJ, Gordon MS, Adams BJ, Gerson SL, Alvarez D, Theuer CP, Leigh BR. A phase I study of daily oral TRC102 (methoxyamine) to enhance the therapeutic effects of pemetrexed in patients with advanced refractory cancer. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 27: 2552. PMID 27961874 DOI: 10.1200/Jco.2009.27.15_Suppl.2552 |
0.336 |
|
| 2009 |
Wang Y, Liu L, Wu C, Bulgar A, Somoza E, Zhu W, Gerson SL. Direct detection and quantification of abasic sites for in vivo studies of DNA damage and repair. Nuclear Medicine and Biology. 36: 975-83. PMID 19875055 DOI: 10.1016/J.Nucmedbio.2009.07.007 |
0.309 |
|
| 2009 |
Barr PM, Fu P, Lazarus HM, Horvath N, Gerson SL, Koc ON, Bahlis NJ, Snell MR, Dowlati A, Cooper BW. Phase I trial of fludarabine, bortezomib and rituximab for relapsed and refractory indolent and mantle cell non-Hodgkin lymphoma. British Journal of Haematology. 147: 89-96. PMID 19656151 DOI: 10.1111/J.1365-2141.2009.07836.X |
0.328 |
|
| 2009 |
Strunk CJ, Platzbecker U, Thiede C, Schaich M, Illmer T, Kang Z, Leahy P, Li C, Xie X, Laughlin MJ, Lazarus HM, Gerson SL, Bunting KD, Ehninger G, Tse W. Elevated AF1q expression is a poor prognostic marker for adult acute myeloid leukemia patients with normal cytogenetics. American Journal of Hematology. 84: 308-9. PMID 19396856 DOI: 10.1002/Ajh.21396 |
0.311 |
|
| 2009 |
Wang F, Dennis JE, Awadallah A, Solchaga LA, Molter J, Kuang Y, Salem N, Lin Y, Tian H, Kolthammer JA, Kim Y, Love ZB, Gerson SL, Lee Z. Transcriptional profiling of human mesenchymal stem cells transduced with reporter genes for imaging. Physiological Genomics. 37: 23-34. PMID 19116247 DOI: 10.1152/Physiolgenomics.00300.2007 |
0.416 |
|
| 2009 |
Qing Y, Wang Z, Liu M, Bunting KD, Gerson SL. Regulation of Hematopoietic Stem Cell Quiescence by Ku70. Blood. 114: 3613-3613. DOI: 10.1182/Blood.V114.22.3613.3613 |
0.373 |
|
| 2009 |
Kenyon J, Saurastri A, Gerson SL. Age Related Expression of hMLH1 but Not hMSH2 in Human Hematopoietic Stem Cells Predicts Genomic Instability. Blood. 114: 3235-3235. DOI: 10.1182/Blood.V114.22.3235.3235 |
0.402 |
|
| 2009 |
Desai A, Qing Y, Liu M, Kenyon J, Nwafor U, Gerson SL. Exo1 Independent DNA Mismatch Repair Pathway in Hematopoiesis. Blood. 114: 2526-2526. DOI: 10.1182/Blood.V114.22.2526.2526 |
0.366 |
|
| 2009 |
Gordon MS, Weiss GJ, Rosen LS, Mendelson DS, Ramanathan RK, Goldman J, Adams BJ, Alvarez D, Liu L, Gerson SL, Theuer CP, Leigh BR. Abstract B62: A phase 1 study of oral TRC102 (methoxyamine), an inhibitor of base‐excision repair, to potentiate the therapeutic effects of pemetrexed in patients with advanced refractory cancer Molecular Cancer Therapeutics. 8. DOI: 10.1158/1535-7163.Targ-09-B62 |
0.316 |
|
| 2009 |
Kindwall-Keller T, Cooper B, Laughlin M, Gerson S, Barr P, Parker P, Jacobs M, Creger R, Lazarus H. Low Infectious Complication Rates in Hematopoietic Stem Cell Transplantation (HSCT) Recipients: Benefits of A Monthly Monitoring System Biology of Blood and Marrow Transplantation. 15: 94-95. DOI: 10.1016/J.Bbmt.2008.12.292 |
0.344 |
|
| 2009 |
Kindwall-Keller T, Cooper B, Laughlin M, Gerson S, Barr P, Erinc S, Creger R, Lazarus H. Preemptive Rituximab Treatment May Reduce the Incidence of Post-Transplant Lymphoproliferative Disorders (PTLD) In Patients with EBV Reactivation after Allogeneic Stem Cell Transplantation Biology of Blood and Marrow Transplantation. 15: 91. DOI: 10.1016/J.Bbmt.2008.12.282 |
0.328 |
|
| 2008 |
Tang Z, Du R, Jiang S, Wu C, Barkauskas DS, Richey J, Molter J, Lam M, Flask C, Gerson S, Dowlati A, Liu L, Lee Z, Halmos B, Wang Y, et al. Dual MET-EGFR combinatorial inhibition against T790M-EGFR-mediated erlotinib-resistant lung cancer. British Journal of Cancer. 99: 911-22. PMID 19238632 DOI: 10.1038/Sj.Bjc.6604559 |
0.315 |
|
| 2008 |
Moioli EK, Clark PA, Chen M, Dennis JE, Erickson HP, Gerson SL, Mao JJ. Synergistic actions of hematopoietic and mesenchymal stem/progenitor cells in vascularizing bioengineered tissues. Plos One. 3: e3922. PMID 19081793 DOI: 10.1371/Journal.Pone.0003922 |
0.369 |
|
| 2008 |
Wald DN, Vermaat HM, Zang S, Lavik A, Kang Z, Peleg G, Gerson SL, Bunting KD, Agarwal ML, Roth BL, Tse W. Identification of 6-benzylthioinosine as a myeloid leukemia differentiation-inducing compound. Cancer Research. 68: 4369-76. PMID 18519698 DOI: 10.1158/0008-5472.Can-07-6559 |
0.406 |
|
| 2008 |
Lee Z, Dennis JE, Gerson SL. Imaging stem cell implant for cellular-based therapies. Experimental Biology and Medicine (Maywood, N.J.). 233: 930-40. PMID 18480418 DOI: 10.3181/0709-Mr-234 |
0.342 |
|
| 2008 |
Lin Y, Molter J, Lee Z, Gerson SL. Bioluminescence imaging of hematopoietic stem cell repopulation in murine models. Methods in Molecular Biology (Clifton, N.J.). 430: 295-306. PMID 18370307 DOI: 10.1007/978-1-59745-182-6_20 |
0.364 |
|
| 2008 |
Gao Y, Lobritz MA, Roth J, Abreha M, Nelson KN, Nankya I, Moore-Dudley DM, Abraha A, Gerson SL, Arts EJ. Targets of small interfering RNA restriction during human immunodeficiency virus type 1 replication. Journal of Virology. 82: 2938-51. PMID 18199654 DOI: 10.1128/Jvi.02126-07 |
0.654 |
|
| 2008 |
Reese JS, Roth JC, Gerson SL. Bone marrow-derived cells exhibiting lung epithelial cell characteristics are enriched in vivo using methylguanine DNA methyltransferase-mediated drug resistance. Stem Cells (Dayton, Ohio). 26: 675-81. PMID 18192231 DOI: 10.1634/Stemcells.2007-0803 |
0.736 |
|
| 2008 |
Gerson S, Keynon J, Qing Y. DNA repair: An essential role in stem cell maintenance Blood Cells, Molecules, and Diseases. 40: 267-268. DOI: 10.1016/J.Bcmd.2007.10.043 |
0.379 |
|
| 2007 |
Kenyon J, Gerson SL. The role of DNA damage repair in aging of adult stem cells. Nucleic Acids Research. 35: 7557-65. PMID 18160407 DOI: 10.1177/0002716284475001040 |
0.4 |
|
| 2007 |
Love Z, Wang F, Dennis J, Awadallah A, Salem N, Lin Y, Weisenberger A, Majewski S, Gerson S, Lee Z. Imaging of mesenchymal stem cell transplant by bioluminescence and PET. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 48: 2011-20. PMID 18006616 DOI: 10.2967/Jnumed.107.043166 |
0.371 |
|
| 2007 |
Liu L, Bulgar A, Donze J, Adams BJ, Theuer CP, Gerson SL. Prevention of base excision repair by TRC102 (methoxyamine) potentiates the anti-tumor activity of pemetrexed in vitro and in vivo Journal of Clinical Oncology. 25: 13005-13005. DOI: 10.1200/Jco.2007.25.18_Suppl.13005 |
0.361 |
|
| 2007 |
Wald DN, Vermaat H, Kang Z, Gerson SL, Bunting KD, Tse W. Identification and Characterization of 6-Benzylthioinosine as a Novel Myeloid Differentiation-Inducing Compound. Blood. 110: 905-905. DOI: 10.1182/Blood.V110.11.905.905 |
0.427 |
|
| 2007 |
Kenyon J, Thomas E, Lingas K, Gerson SL. Differential hMLH1 Gene Expression after Temozolomide Selection Linked to Microsatellite Instability in a Subset of Hematopoietic Stem/Progenitor Cells in Old Versus Young and Cancer Versus Normal Patient Samples. Blood. 110: 509-509. DOI: 10.1182/Blood.V110.11.509.509 |
0.451 |
|
| 2007 |
Reese JS, Lingas KT, Sweeney CL, Brell JM, Gerson SL. Safety of MGMT Gene Transfer into Hematopoietic Progenitors: A Phase I Clinical Trial Using Retroviral Gene Transfer of G156A MGMT To Protect Hematopoiesis during BG Plus Alkylating Agent Treatment of Advanced Malignancies. Blood. 110: 500-500. DOI: 10.1182/Blood.V110.11.500.500 |
0.426 |
|
| 2007 |
Sweeney CL, Lin Y, Gerson SL. Retroviral Insertion and Temozolomide Selection Promote T-Cell Lymphomas in Tumor-Prone Mice. Blood. 110: 2593-2593. DOI: 10.1182/Blood.V110.11.2593.2593 |
0.483 |
|
| 2007 |
Qing Y, Gerson SL. Loss of Ku70 Results in a HSC Repopulating Defect. Blood. 110: 1256-1256. DOI: 10.1182/Blood.V110.11.1256.1256 |
0.404 |
|
| 2007 |
Reese JS, Solchaga LA, Lingas KT, Lazarus HM, Gerson SL. Improved Culture Expansion of Human Mesenchymal Stem Cells (MSCs) Using Fibroblastic Growth Factor-2 for the Treatment of Graft Versus Host Disease (GVHD). Blood. 110: 1207-1207. DOI: 10.1182/Blood.V110.11.1207.1207 |
0.365 |
|
| 2006 |
Gerson SL, Reese J, Kenyon J. DNA repair in stem cell maintenance and conversion to cancer stem cells. Ernst Schering Foundation Symposium Proceedings. 231-44. PMID 17939304 |
0.316 |
|
| 2006 |
Fu P, Bagai RK, Meyerson H, Kane D, Fox RM, Creger RJ, Cooper BW, Gerson SL, Laughlin MJ, Koc ON, Lazarus HM. Pre-mobilization therapy blood CD34+ cell count predicts the likelihood of successful hematopoietic stem cell mobilization. Bone Marrow Transplantation. 38: 189-96. PMID 16850032 DOI: 10.1038/Sj.Bmt.1705431 |
0.341 |
|
| 2006 |
Yüksel M, Baron E, Camouse M, Cooper BW, Lazarus HM, Gerson SL, Laughlin MJ, Cooper KD, Gilliam A, Fu P, Stevens S, Koç ON. Peritransplant use of ultraviolet-B irradiation (UV-B) therapy is detrimental to allogeneic stem cell transplantation outcome. Biology of Blood and Marrow Transplantation : Journal of the American Society For Blood and Marrow Transplantation. 12: 665-71. PMID 16737940 DOI: 10.1016/J.Bbmt.2006.02.004 |
0.344 |
|
| 2006 |
An FQ, Folarin HM, Compitello N, Roth J, Gerson SL, McCrae KR, Fakhari FD, Dittmer DP, Renne R. Long-term-infected telomerase-immortalized endothelial cells: a model for Kaposi's sarcoma-associated herpesvirus latency in vitro and in vivo. Journal of Virology. 80: 4833-46. PMID 16641275 DOI: 10.1128/Jvi.80.10.4833-4846.2006 |
0.715 |
|
| 2006 |
Fontes AM, Davis BM, Encell LP, Lingas K, Covas DT, Zago MA, Loeb LA, Pegg AE, Gerson SL. Differential competitive resistance to methylating versus chloroethylating agents among five O6-alkylguanine DNA alkyltransferases in human hematopoietic cells. Molecular Cancer Therapeutics. 5: 121-8. PMID 16432170 DOI: 10.1158/1535-7163.Mct-05-0236 |
0.379 |
|
| 2006 |
Liu L, Gerson SL. Targeted modulation of MGMT: clinical implications. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 12: 328-31. PMID 16428468 DOI: 10.1158/1078-0432.Ccr-05-2543 |
0.349 |
|
| 2006 |
van Heeckeren WJ, Vollweiler J, Fu P, Cooper BW, Meyerson H, Lazarus HM, Simic A, Laughlin MJ, Gerson SL, Koç ON. Randomised comparison of two B-cell purging protocols for patients with B-cell non-Hodgkin lymphoma: in vivo purging with rituximab versus ex vivo purging with CliniMACS CD34 cell enrichment device. British Journal of Haematology. 132: 42-55. PMID 16371019 DOI: 10.1111/J.1365-2141.2005.05827.X |
0.361 |
|
| 2006 |
Lin Y, Gerson SL. Efficient Viral Transduction of Murine Hematopoietic Stem Cells Using HIV-1 Gag-Pol Cross Packaged Simian Immunodeficiency Viral Backbone. Blood. 108: 5484-5484. DOI: 10.1182/Blood.V108.11.5484.5484 |
0.396 |
|
| 2006 |
Rizzieri DA, Tse W, Khan KD, Advani A, Donze J, Karsten V, Geller RB, Gerson SL. A Phase I Study of Cloretazine® and Temozolomide in Patients with Hematologic Malignancies. Blood. 108: 1971-1971. DOI: 10.1182/Blood.V108.11.1971.1971 |
0.305 |
|
| 2006 |
Gerson SL, Dettling M, Dain B, Lachowicz M, Kane J, Malhotra A, Cascorbi I, Mosyagin I, Reed C, Athanasiou M. Replication of Genetic Markers Associated with Clozapine-Induced Agranulocytosis. Blood. 108: 1280-1280. DOI: 10.1182/Blood.V108.11.1280.1280 |
0.303 |
|
| 2005 |
Bahlis NJ, Miao Y, Koc ON, Lee K, Boise LH, Gerson SL. N-benzoylstaurosporine (PKC412) inhibits Akt kinase inducing apoptosis in multiple myeloma cells. Leukemia & Lymphoma. 46: 899-908. PMID 16019536 DOI: 10.1080/10428190500080595 |
0.331 |
|
| 2005 |
Lazarus HM, Koc ON, Devine SM, Curtin P, Maziarz RT, Holland HK, Shpall EJ, McCarthy P, Atkinson K, Cooper BW, Gerson SL, Laughlin MJ, Loberiza FR, Moseley AB, Bacigalupo A. Cotransplantation of HLA-identical sibling culture-expanded mesenchymal stem cells and hematopoietic stem cells in hematologic malignancy patients. Biology of Blood and Marrow Transplantation : Journal of the American Society For Blood and Marrow Transplantation. 11: 389-98. PMID 15846293 DOI: 10.1016/J.Bbmt.2005.02.001 |
0.39 |
|
| 2005 |
Park Y, Gerson SL. DNA repair defects in stem cell function and aging. Annual Review of Medicine. 56: 495-508. PMID 15660524 DOI: 10.1146/Annurev.Med.56.082103.104546 |
0.404 |
|
| 2005 |
Wadhwa PD, Fu P, Koc ON, Cooper BW, Fox RM, Creger RJ, Bajor DL, Bedi T, Laughlin MJ, Payne J, Gerson SL, Lazarus HM. High-dose carmustine, etoposide, and cisplatin for autologous stem cell transplantation with or without involved-field radiation for relapsed/refractory lymphoma: an effective regimen with low morbidity and mortality. Biology of Blood and Marrow Transplantation : Journal of the American Society For Blood and Marrow Transplantation. 11: 13-22. PMID 15625540 DOI: 10.1016/J.Bbmt.2004.09.003 |
0.346 |
|
| 2005 |
Gerson SL, O’Brien S, Donze J, Karsten V, Karp J, Rizzieri D, Verhoef G, Daenen S, Sznol M, Giles F. Analysis of pre-treatment O6-alkylguanine transferase (AGT) levels in patients (pts) with hematologic malignancies receiving VNP40101M (101M) Journal of Clinical Oncology. 23: 6542-6542. DOI: 10.1200/Jco.2005.23.16_Suppl.6542 |
0.303 |
|
| 2005 |
Strunk CJ, Platzbecker U, Thiede C, Schaich MA, Illmer T, Kang Z, Leahy P, Li C, Reiner S, Laughlin MJ, Lazarus HM, Bunting KD, Gerson SL, Ehninger G, Tse WW. AF1q Is a Novel Poor Prognostic Marker for Adult Acute Myelogenous Leukemia (AML) Patients with Normal Cytogenetics. Blood. 106: 3294-3294. DOI: 10.1182/Blood.V106.11.3294.3294 |
0.344 |
|
| 2005 |
Sweeney CL, Groh M, Maitra B, Szekely E, Koç ON, Gerson SL. Malignant Transformation of a PG13 Cell Line Producing an MFG Retroviral Vector Containing Wild-Type Murine Akt. Blood. 106: 3049-3049. DOI: 10.1182/Blood.V106.11.3049.3049 |
0.451 |
|
| 2005 |
Sweeney CL, Lingas K, Reese JS, Flick S, Gerson SL. Retrovirus Insertion Site Analysis Following In Vivo Drug Selection in a Phase I Clinical Trial Utilizing G156A MGMT for Enhanced Chemotherapy of Advanced Malignancies. Blood. 106: 3048-3048. DOI: 10.1182/Blood.V106.11.3048.3048 |
0.432 |
|
| 2005 |
Kenyon JD, Park Y, Marcus RE, Goldberg VM, Gerson SL. Human Hematopoietic Progenitor Cells Exhibit Increased Microsatellite Instability Associated with Advanced Age. Blood. 106: 2284-2284. DOI: 10.1182/Blood.V106.11.2284.2284 |
0.331 |
|
| 2005 |
Gerson SL. Selection without harm: Drug resistance gene therapy hits the big time Blood. 105: 914. DOI: 10.1182/Blood-2004-11-4251 |
0.409 |
|
| 2004 |
Cooper BW, Veal GJ, Radivoyevitch T, Tilby MJ, Meyerson HJ, Lazarus HM, Koc ON, Creger RJ, Pearson G, Nowell GM, Gosky D, Ingalls ST, Hoppel CL, Gerson SL. A phase I and pharmacodynamic study of fludarabine, carboplatin, and topotecan in patients with relapsed, refractory, or high-risk acute leukemia. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 6830-9. PMID 15501959 DOI: 10.1158/1078-0432.Ccr-04-0097 |
0.303 |
|
| 2004 |
Richard E, Robert E, Cario-André M, Ged C, Géronimi F, Gerson SL, de Verneuil H, Moreau-Gaudry F. Hematopoietic stem cell gene therapy of murine protoporphyria by methylguanine-DNA-methyltransferase-mediated in vivo drug selection. Gene Therapy. 11: 1638-47. PMID 15284838 DOI: 10.1038/Sj.Gt.3302335 |
0.451 |
|
| 2004 |
Zielske SP, Lingas KT, Li Y, Gerson SL. Limited lentiviral transgene expression with increasing copy number in an MGMT selection model: lack of copy number selection by drug treatment. Molecular Therapy : the Journal of the American Society of Gene Therapy. 9: 923-31. PMID 15194059 DOI: 10.1016/J.Ymthe.2004.02.017 |
0.711 |
|
| 2004 |
Gerson SL. MGMT: its role in cancer aetiology and cancer therapeutics. Nature Reviews. Cancer. 4: 296-307. PMID 15057289 DOI: 10.1038/Nrc1319 |
0.422 |
|
| 2004 |
Hammond LA, Eckardt JR, Kuhn JG, Gerson SL, Johnson T, Smith L, Drengler RL, Campbell E, Weiss GR, Von Hoff DD, Rowinsky EK. A randomized phase I and pharmacological trial of sequences of 1,3-bis(2-chloroethyl)-1-nitrosourea and temozolomide in patients with advanced solid neoplasms. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 1645-56. PMID 15014015 DOI: 10.1158/1078-0432.Ccr-03-0174 |
0.338 |
|
| 2004 |
Gajewski TF, Sosman J, Peterson AC, Gerson S, Dolan E, Vokes E. Phase II trial of O6-benzylguanine (O6BG) and BCNU in patients with advanced melanoma Journal of Clinical Oncology. 22: 7524-7524. DOI: 10.1200/Jco.2004.22.90140.7524 |
0.352 |
|
| 2004 |
Fu P, Van Heeckeren WJ, Wadhwa PD, Bajor DJ, Creger RJ, Cooper BW, Laughlin MJ, Lazarus HM, Gerson SL, Koc ON. Time-Dependent Effect of Non-Hodgkin’s Lymphoma Grade on Disease Free Survival (DSF) of Relapsed/Refractory Patients Treated with High-Dose Chemotherapy (HDC) Plus Autologous Hematopoietic Stem Cell Transplant (AHSCT). Blood. 104: 917-917. DOI: 10.1182/Blood.V104.11.917.917 |
0.349 |
|
| 2004 |
Reese JS, Roth JC, Gerson SL. Drug Selection Enrichment of Type II Pneumocytes Following Transplant of P140K MGMT Lentiviral Transduced Hematopoietic Stem Cells. Blood. 104: 3594-3594. DOI: 10.1182/Blood.V104.11.3594.3594 |
0.754 |
|
| 2004 |
Maisel C, Bahlis N, Miao Y, Liu L, Gerson S. Depletion of the Intracellular Akt Kinase, and Its Downstream Signaling, Mediates Synergy between the Proteasome Inhibitor MG-132 and the Heat Shock Protein 90 Inhibitor 17-AAG in the Multiple Myeloma Cell Line U266. Blood. 104: 3364-3364. DOI: 10.1182/Blood.V104.11.3364.3364 |
0.304 |
|
| 2004 |
Park Y, Lin Y, Gerson SL. Lack of Functional DNA-PKcs and DNA Double-Strand Break Repair Leads to a Repopulating Stem Cell Defect in Scid Mice. Blood. 104: 2684-2684. DOI: 10.1182/Blood.V104.11.2684.2684 |
0.407 |
|
| 2004 |
Park Y, Luo G, Gerson S. Repopulation Advantage of Blm−/− Cells in the Primary Recipients Can Be Reversed by Cisplatin Treatment. Blood. 104: 2683-2683. DOI: 10.1182/Blood.V104.11.2683.2683 |
0.385 |
|
| 2004 |
Yuksel M, Baron E, Cooper BW, Lazarus HM, Gerson SL, Laughlin MJ, Cooper KD, Gilliam A, Koc ON. Peritransplant Use of Ultraviolet-B (UVB) Phototherapy Is Detrimental to Outcome of Allogeneic Stem Cell Transplantation. Blood. 104: 1843-1843. DOI: 10.1182/Blood.V104.11.1843.1843 |
0.341 |
|
| 2004 |
Lin Y, Cheung P, Wilson DL, Gerson SL. Dynamic Patterns of Migration and Expansion of Hematopoiesis during MGMT Mediated Drug Selection. Blood. 104: 156-156. DOI: 10.1182/Blood.V104.11.156.156 |
0.434 |
|
| 2004 |
Reese J, Lingas K, Ksenich P, Sweeney C, Koc O, Gerson S. 1006. Preliminary Results of a Phase I Trial Using Retroviral Gene Transfer of G156A MGMT To Protect Hematopoiesis during BG and BCNU Therapy of Advanced Malignancies Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.944 |
0.422 |
|
| 2004 |
Roth JC, Ismail M, Ferrari G, Gerson SL. 914. Mutant MGMT Lentivirus Co-Transduction ith a Marker Lentivirus Efficiently Enriches for Dual-Vector Expressing Cells In Vivo Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.820 |
0.753 |
|
| 2003 |
Zielske SP, Reese JS, Lingas KT, Donze JR, Gerson SL. In vivo selection of MGMT(P140K) lentivirus-transduced human NOD/SCID repopulating cells without pretransplant irradiation conditioning. The Journal of Clinical Investigation. 112: 1561-70. PMID 14617757 DOI: 10.1172/Jci17922 |
0.753 |
|
| 2003 |
Davis BM, Reese JS, Lingas K, Gerson SL. Drug selection of mutant methylguanine methyltransferase from different oncoretroviral backbones results in multilineage hematopoietic transgene expression in primary and secondary recipients. Journal of Hematotherapy & Stem Cell Research. 12: 375-87. PMID 12965075 DOI: 10.1089/152581603322286015 |
0.456 |
|
| 2003 |
Richard E, Géronimi F, Lalanne M, Ged C, Redonnet-Vernhet I, Lamrissi-Garcia I, Gerson SL, de Verneuil H, Moreau-Gaudry F. A bicistronic SIN-lentiviral vector containing G156A MGMT allows selection and metabolic correction of hematopoietic protoporphyric cell lines. The Journal of Gene Medicine. 5: 737-47. PMID 12950064 DOI: 10.1002/Jgm.407 |
0.392 |
|
| 2003 |
Koç ON, Gerson SL. Akt helps stem cells heal the heart. Nature Medicine. 9: 1109-10. PMID 12949518 DOI: 10.1038/Nm0903-1109 |
0.348 |
|
| 2003 |
Odago FO, Gerson SL. Telomerase inhibition and telomere erosion: a two-pronged strategy in cancer therapy. Trends in Pharmacological Sciences. 24: 328-31. PMID 12871663 DOI: 10.1016/S0165-6147(03)00165-2 |
0.34 |
|
| 2003 |
Zielske SP, Gerson SL. SarCNU mediates selection of P140K methylguanine-DNA-methyltransferase transduced human CD34(+) cells in vitro. Blood Cells, Molecules & Diseases. 31: 48-50. PMID 12850483 DOI: 10.1016/S1079-9796(03)00060-3 |
0.736 |
|
| 2003 |
Bowman JE, Reese JS, Lingas KT, Gerson SL. Myeloablation is not required to select and maintain expression of the drug-resistance gene, mutant MGMT, in primary and secondary recipients. Molecular Therapy : the Journal of the American Society of Gene Therapy. 8: 42-50. PMID 12842427 DOI: 10.1016/S1525-0016(03)00141-2 |
0.461 |
|
| 2003 |
Vollweiler JL, Zielske SP, Reese JS, Gerson SL. Hematopoietic stem cell gene therapy: progress toward therapeutic targets. Bone Marrow Transplantation. 32: 1-7. PMID 12815471 DOI: 10.1038/sj.bmt.1704081 |
0.736 |
|
| 2003 |
Reese JS, Liu L, Gerson SL. Repopulating defect of mismatch repair-deficient hematopoietic stem cells. Blood. 102: 1626-33. PMID 12730104 DOI: 10.1182/Blood-2002-10-3035 |
0.441 |
|
| 2003 |
Tolcher AW, Gerson SL, Denis L, Geyer C, Hammond LA, Patnaik A, Goetz AD, Schwartz G, Edwards T, Reyderman L, Statkevich P, Cutler DL, Rowinsky EK. Marked inactivation of O6-alkylguanine-DNA alkyltransferase activity with protracted temozolomide schedules. British Journal of Cancer. 88: 1004-11. PMID 12671695 DOI: 10.1038/Sj.Bjc.6600827 |
0.346 |
|
| 2003 |
Zielske SP, Gerson SL. Cytokines, including stem cell factor alone, enhance lentiviral transduction in nondividing human LTCIC and NOD/SCID repopulating cells. Molecular Therapy : the Journal of the American Society of Gene Therapy. 7: 325-33. PMID 12668128 DOI: 10.1016/S1525-0016(03)00005-4 |
0.738 |
|
| 2003 |
Cooper BW, Donaher E, Lazarus HM, Green SB, Gosky DM, Rosenthal NS, Berger SJ, Li X, Ingalls ST, Hoppel CL, Gerson SL. A phase I and pharmacodynamic study of sequential topotecan and etoposide in patients with relapsed or refractory acute myelogenous and lymphoblastic leukemia. Leukemia Research. 27: 35-44. PMID 12479850 DOI: 10.1016/S0145-2126(02)00079-6 |
0.305 |
|
| 2002 |
Koç ON, Day J, Nieder M, Gerson SL, Lazarus HM, Krivit W. Allogeneic mesenchymal stem cell infusion for treatment of metachromatic leukodystrophy (MLD) and Hurler syndrome (MPS-IH). Bone Marrow Transplantation. 30: 215-22. PMID 12203137 DOI: 10.1038/Sj.Bmt.1703650 |
0.371 |
|
| 2002 |
Ballas CB, Zielske SP, Gerson SL. Adult bone marrow stem cells for cell and gene therapies: implications for greater use. Journal of Cellular Biochemistry. Supplement. 38: 20-8. PMID 12046846 DOI: 10.1002/Jcb.10127 |
0.741 |
|
| 2002 |
Gerson SL. Clinical relevance of MGMT in the treatment of cancer. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 20: 2388-99. PMID 11981013 DOI: 10.1200/Jco.2002.06.110 |
0.443 |
|
| 2002 |
Zielske SP, Gerson SL. Lentiviral transduction of P140K MGMT into human CD34(+) hematopoietic progenitors at low multiplicity of infection confers significant resistance to BG/BCNU and allows selection in vitro. Molecular Therapy : the Journal of the American Society of Gene Therapy. 5: 381-7. PMID 11945064 DOI: 10.1006/Mthe.2002.0571 |
0.747 |
|
| 2002 |
Wadhwa PD, Zielske SP, Roth JC, Ballas CB, Bowman JE, Gerson SL. Cancer gene therapy: scientific basis. Annual Review of Medicine. 53: 437-52. PMID 11818484 DOI: 10.1146/Annurev.Med.53.082901.104039 |
0.77 |
|
| 2002 |
Ballas CB, Zielske SP, Gerson SL. Stem cells and the philosopher's stone Journal of Cellular Biochemistry. 85: 13-19. DOI: 10.1002/jcb.10098 |
0.709 |
|
| 2001 |
Lee K, Gerson SL, Maitra B, Koç ON. G156A MGMT-transduced human mesenchymal stem cells can be selectively enriched by O6-benzylguanine and BCNU. Journal of Hematotherapy & Stem Cell Research. 10: 691-701. PMID 11672516 DOI: 10.1089/152581601753193913 |
0.463 |
|
| 2001 |
Taverna P, Liu L, Hwang HS, Hanson AJ, Kinsella TJ, Gerson SL. Methoxyamine potentiates DNA single strand breaks and double strand breaks induced by temozolomide in colon cancer cells. Mutation Research. 485: 269-81. PMID 11585361 DOI: 10.1016/S0921-8777(01)00076-3 |
0.391 |
|
| 2001 |
Dowlati A, Hoppel CL, Ingalls ST, Majka S, Li X, Sedransk N, Spiro T, Gerson SL, Ivy P, Remick SC. Phase I clinical and pharmacokinetic study of rebeccamycin analog NSC 655649 given daily for five consecutive days. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 19: 2309-18. PMID 11304785 DOI: 10.1200/Jco.2001.19.8.2309 |
0.301 |
|
| 2001 |
Davis BM, Encell LP, Zielske SP, Christians FC, Liu L, Friebert SE, Loeb LA, Gerson SL. Applied molecular evolution of O6-benzylguanine-resistant DNA alkyltransferases in human hematopoietic cells. Proceedings of the National Academy of Sciences of the United States of America. 98: 4950-4. PMID 11296271 DOI: 10.1073/Pnas.091601198 |
0.726 |
|
| 2001 |
Reese JS, Qin X, Ballas CB, Sekiguchi M, Gerson SL. MGMT expression in murine bone marrow is a major determinant of animal survival after alkylating agent exposure. Journal of Hematotherapy & Stem Cell Research. 10: 115-23. PMID 11276365 DOI: 10.1089/152581601750098354 |
0.411 |
|
| 2000 |
Majumdar MK, Thiede MA, Haynesworth SE, Bruder SP, Gerson SL. Human marrow-derived mesenchymal stem cells (MSCs) express hematopoietic cytokines and support long-term hematopoiesis when differentiated toward stromal and osteogenic lineages. Journal of Hematotherapy & Stem Cell Research. 9: 841-8. PMID 11177595 DOI: 10.1089/152581600750062264 |
0.335 |
|
| 2000 |
Gerson SL. Drug resistance gene transfer: Stem cell protection and therapeutic efficacy. Experimental Hematology. 28: 1315-24. PMID 11146153 DOI: 10.1016/S0301-472X(00)00548-8 |
0.396 |
|
| 2000 |
Taverna P, Liu L, Hanson AJ, Monks A, Gerson SL. Characterization of MLH1 and MSH2 DNA mismatch repair proteins in cell lines of the NCI anticancer drug screen. Cancer Chemotherapy and Pharmacology. 46: 507-16. PMID 11138465 DOI: 10.1007/S002800000186 |
0.391 |
|
| 2000 |
Chen R, Nagarajan S, Prince GM, Maheshwari U, Terstappen LW, Kaplan DR, Gerson SL, Albert JM, Dunn DE, Lazarus HM, Medof ME. Impaired growth and elevated fas receptor expression in PIGA(+) stem cells in primary paroxysmal nocturnal hemoglobinuria. The Journal of Clinical Investigation. 106: 689-96. PMID 10974022 DOI: 10.1172/Jci8328 |
0.301 |
|
| 2000 |
Davis BM, Koç ON, Gerson SL. Limiting numbers of G156A O(6)-methylguanine-DNA methyltransferase-transduced marrow progenitors repopulate nonmyeloablated mice after drug selection. Blood. 95: 3078-84. PMID 10807772 DOI: 10.1182/Blood.V95.10.3078 |
0.451 |
|
| 2000 |
Qin X, Shibata D, Gerson SL. Heterozygous DNA mismatch repair gene PMS2-knockout mice are susceptible to intestinal tumor induction with N-methyl-N-nitrosourea. Carcinogenesis. 21: 833-8. PMID 10753224 DOI: 10.1093/Carcin/21.4.833 |
0.309 |
|
| 2000 |
Lazarus HM, Pecora AL, Shea TC, Koç ON, White JM, Gabriel DA, Cooper BW, Gerson SL, Krieger M, Sing AP. CD34+ selection of hematopoietic blood cell collections and autotransplantation in lymphoma: overnight storage of cells at 4 degrees C does not affect outcome. Bone Marrow Transplantation. 25: 559-66. PMID 10713636 DOI: 10.1038/Sj.Bmt.1702175 |
0.317 |
|
| 2000 |
Koç ON, Gerson SL, Cooper BW, Dyhouse SM, Haynesworth SE, Caplan AI, Lazarus HM. Rapid hematopoietic recovery after coinfusion of autologous-blood stem cells and culture-expanded marrow mesenchymal stem cells in advanced breast cancer patients receiving high-dose chemotherapy. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 18: 307-16. PMID 10637244 DOI: 10.1200/Jco.2000.18.2.307 |
0.41 |
|
| 2000 |
Zielske SP, Gerson SL. Drug resistance of human hematopoietic stem cells transduced with mgmt p140k using a lentiviral vector at low multiplicity of infection Blood. 96. |
0.734 |
|
| 2000 |
Reese JS, Liu L, Gerson SL. Mismatch repair deficient hematopoietic stem cells have an early selection advantage/a vivo but experience late exhaustion after methylating agent exposure Blood. 96. |
0.32 |
|
| 2000 |
Bowman JE, Davis BM, Gerson SL. Competitive in vivo selection for MFG-P140K MGMT and MFG-G156A MGMT transduced murine progenitors in secondary recipient mice using o6-benzylguanine and bcnu Blood. 96. |
0.33 |
|
| 1999 |
Reese JS, Koç ON, Gerson SL. Human mesenchymal stem cells provide stromal support for efficient CD34+ transduction. Journal of Hematotherapy & Stem Cell Research. 8: 515-23. PMID 10791902 DOI: 10.1089/152581699319966 |
0.452 |
|
| 1999 |
Davis BM, Roth JC, Liu L, Xu-Welliver M, Pegg AE, Gerson SL. Characterization of the P140K, PVP(138-140)MLK, and G156A O6-methylguanine-DNA methyltransferase mutants: implications for drug resistance gene therapy. Human Gene Therapy. 10: 2769-78. PMID 10584923 DOI: 10.1089/10430349950016500 |
0.726 |
|
| 1999 |
Koç ON, Peters C, Aubourg P, Raghavan S, Dyhouse S, DeGasperi R, Kolodny EH, Yoseph YB, Gerson SL, Lazarus HM, Caplan AI, Watkins PA, Krivit W. Bone marrow-derived mesenchymal stem cells remain host-derived despite successful hematopoietic engraftment after allogeneic transplantation in patients with lysosomal and peroxisomal storage diseases. Experimental Hematology. 27: 1675-81. PMID 10560915 DOI: 10.1016/S0301-472X(99)00101-0 |
0.385 |
|
| 1999 |
Qin X, Zhou H, Liu L, Gerson SL. Transgenic expression of human MGMT blocks the hypersensitivity of PMS2-deficient mice to low dose MNU thymic lymphomagenesis. Carcinogenesis. 20: 1667-73. PMID 10469609 DOI: 10.1093/Carcin/20.9.1667 |
0.329 |
|
| 1999 |
Phillips WP, Gerson SL. Acquired resistance to O6-benzylguanine plus chloroethylnitrosoureas in human breast cancer. Cancer Chemotherapy and Pharmacology. 44: 319-26. PMID 10447580 DOI: 10.1007/S002800050984 |
0.339 |
|
| 1999 |
Qin X, Liu L, Gerson SL. Mice defective in the DNA mismatch gene PMS2 are hypersensitive to MNU induced thymic lymphoma and are partially protected by transgenic expression of human MGMT. Oncogene. 18: 4394-400. PMID 10439048 DOI: 10.1038/Sj.Onc.1202798 |
0.361 |
|
| 1999 |
Koç ON, Reese JS, Szekely EM, Gerson SL. Human long-term culture initiating cells are sensitive to benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea and protected after mutant (G156A) methylguanine methyltransferase gene transfer. Cancer Gene Therapy. 6: 340-8. PMID 10419052 DOI: 10.1038/Sj.Cgt.7700067 |
0.401 |
|
| 1999 |
Davis BM, Koç ON, Reese JS, Gerson SL. O6-benzylguanine-resistant mutant MGMT genes improve hematopoietic cell tolerance to alkylating agents. Progress in Experimental Tumor Research. 36: 65-81. PMID 10386065 DOI: 10.1159/000061986 |
0.378 |
|
| 1999 |
Koç ON, Reese JS, Davis BM, Liu L, Majczenko KJ, Gerson SL. DeltaMGMT-transduced bone marrow infusion increases tolerance to O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea and allows intensive therapy of 1,3-bis(2-chloroethyl)-1-nitrosourea-resistant human colon cancer xenografts. Human Gene Therapy. 10: 1021-30. PMID 10223735 DOI: 10.1089/10430349950018418 |
0.425 |
|
| 1999 |
Gerson SL. Mesenchymal stem cells: no longer second class marrow citizens. Nature Medicine. 5: 262-4. PMID 10086373 DOI: 10.1038/6470 |
0.385 |
|
| 1999 |
Liu L, Qin X, Gerson SL. Reduced lung tumorigenesis in human methylguanine DNA--methyltransferase transgenic mice achieved by expression of transgene within the target cell. Carcinogenesis. 20: 279-84. PMID 10069465 DOI: 10.1093/Carcin/20.2.279 |
0.318 |
|
| 1999 |
Reese JS, Davis BM, Liu L, Gerson SL. Simultaneous protection of G156A methylguanine DNA methyltransferase gene-transduced hematopoietic progenitors and sensitization of tumor cells using O6-benzylguanine and temozolomide. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 5: 163-9. PMID 9918215 |
0.369 |
|
| 1998 |
Majumdar MK, Thiede MA, Mosca JD, Moorman M, Gerson SL. Phenotypic and functional comparison of cultures of marrow-derived mesenchymal stem cells (MSCs) and stromal cells. Journal of Cellular Physiology. 176: 57-66. PMID 9618145 DOI: 10.1002/(Sici)1097-4652(199807)176:1<57::Aid-Jcp7>3.0.Co;2-7 |
0.367 |
|
| 1998 |
Koç ON, Gerson SL, Phillips GL, Cooper BW, Kutteh L, Van Zant G, Reece DE, Fox RM, Schupp JE, Tainer N, Lazarus HM. Autologous CD34+ cell transplantation for patients with advanced lymphoma: effects of overnight storage on peripheral blood progenitor cell enrichment and engraftment. Bone Marrow Transplantation. 21: 337-43. PMID 9509966 DOI: 10.1038/Sj.Bmt.1701096 |
0.357 |
|
| 1997 |
Davis BM, Reese JS, Koç ON, Lee K, Schupp JE, Gerson SL. Selection for G156A O6-methylguanine DNA methyltransferase gene-transduced hematopoietic progenitors and protection from lethality in mice treated with O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea. Cancer Research. 57: 5093-9. PMID 9371508 |
0.362 |
|
| 1997 |
Lazarus HM, Haynesworth SE, Gerson SL, Caplan AI. Human bone marrow-derived mesenchymal (stromal) progenitor cells (MPCs) cannot be recovered from peripheral blood progenitor cell collections. Journal of Hematotherapy. 6: 447-55. PMID 9368181 DOI: 10.1089/Scd.1.1997.6.447 |
0.373 |
|
| 1997 |
Allay JA, Davis BM, Gerson SL. Human alkyltransferase-transduced murine myeloid progenitors are enriched in vivo by BCNU treatment of transplanted mice. Experimental Hematology. 25: 1069-76. PMID 9293904 |
0.332 |
|
| 1997 |
Allay JA, Dennis JE, Haynesworth SE, Majumdar MK, Clapp DW, Shultz LD, Caplan AI, Gerson SL. LacZ and interleukin-3 expression in vivo after retroviral transduction of marrow-derived human osteogenic mesenchymal progenitors. Human Gene Therapy. 8: 1417-27. PMID 9287142 DOI: 10.1089/Hum.1997.8.12-1417 |
0.376 |
|
| 1996 |
Allay JA, Koç ON, Davis BM, Gerson SL. Retroviral-mediated gene transduction of human alkyltransferase complementary DNA confers nitrosourea resistance to human hematopoietic progenitors. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 2: 1353-9. PMID 9816307 |
0.346 |
|
| 1996 |
Davis BM, Koc ON, Lee K, Gerson SL. Current progress in the gene therapy of cancer. Current Opinion in Oncology. 8: 499-508. PMID 8971470 DOI: 10.1097/00001622-199611000-00010 |
0.367 |
|
| 1996 |
Reese JS, Koç ON, Lee KM, Liu L, Allay JA, Phillips WP, Gerson SL. Retroviral transduction of a mutant methylguanine DNA methyltransferase gene into human CD34 cells confers resistance to O6-benzylguanine plus 1,3-bis(2-chloroethyl)-1-nitrosourea. Proceedings of the National Academy of Sciences of the United States of America. 93: 14088-93. PMID 8943065 DOI: 10.1073/Pnas.93.24.14088 |
0.429 |
|
| 1996 |
Koç ON, Phillips WP, Lee K, Liu L, Zaidi NH, Allay JA, Gerson SL. Role of DNA repair in resistance to drugs that alkylate O6 of guanine. Cancer Treatment and Research. 87: 123-46. PMID 8886451 DOI: 10.1007/978-1-4613-1267-3_5 |
0.4 |
|
| 1996 |
Gerson SL, Phillips W, Kastan M, Dumenco LL, Donovan C. Human CD34+ hematopoietic progenitors have low, cytokine-unresponsive O6-alkylguanine-DNA alkyltransferase and are sensitive to O6-benzylguanine plus BCNU. Blood. 88: 1649-55. PMID 8781420 DOI: 10.1182/Blood.V88.5.1649.Bloodjournal8851649 |
0.425 |
|
| 1996 |
Wakazono Y, Kubota M, Furusho K, Liu L, Gerson SL. Thymidine kinase deficient cells with decreased TTP pools are hypersensitive to DNA alkylating agents. Mutation Research. 362: 119-25. PMID 8538643 DOI: 10.1016/0921-8777(95)00042-9 |
0.389 |
|
| 1995 |
Zaidi NH, Allay E, Ayi TC, Li BF, Dumenco LL, Sy MS, Gerson SL. The immature thymocyte is protected from N-methylnitrosourea-induced lymphoma by the human MGMT-CD2 transgene. Carcinogenesis. 16: 1047-53. PMID 7767963 DOI: 10.1093/Carcin/16.5.1047 |
0.31 |
|
| 1995 |
Allay JA, Dumenco LL, Koc ON, Liu L, Gerson SL. Retroviral transduction and expression of the human alkyltransferase cDNA provides nitrosourea resistance to hematopoietic cells. Blood. 85: 3342-51. PMID 7756667 DOI: 10.1182/Blood.V85.11.3342.Bloodjournal85113342 |
0.472 |
|
| 1995 |
Willson JK, Haaga JR, Trey JE, Stellato TA, Gordon NH, Gerson SL. Modulation of O6-alkylguanine alkyltransferase-directed DNA repair in metastatic colon cancers. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 13: 2301-8. PMID 7666087 DOI: 10.1200/Jco.1995.13.9.2301 |
0.366 |
|
| 1995 |
Gerson SL, Willson JK. O6-alkylguanine-DNA alkyltransferase. A target for the modulation of drug resistance. Hematology/Oncology Clinics of North America. 9: 431-50. PMID 7642472 DOI: 10.1016/S0889-8588(18)30103-5 |
0.348 |
|
| 1995 |
Clapp DW, Freie B, Srour E, Yoder MC, Fortney K, Gerson SL. Myeloproliferative sarcoma virus directed expression of beta-galactosidase following retroviral transduction of murine hematopoietic cells. Experimental Hematology. 23: 630-8. PMID 7601255 |
0.334 |
|
| 1995 |
Mendelowitz AJ, Gerson SL, Alvir JMJ, Lieberman JA. Clozapine-Induced Agranulocytosis: Risk Factors, Monitoring and Management Cns Drugs. 4: 412-421. DOI: 10.2165/00023210-199504060-00004 |
0.333 |
|
| 1994 |
Gerson SL, Berger SJ, Varnes ME, Donovan C. Combined depletion of O6-alkylguanine-DNA alkyltransferase and glutathione to modulate nitrosourea resistance in breast cancer. Biochemical Pharmacology. 48: 543-8. PMID 8068041 DOI: 10.1016/0006-2952(94)90284-4 |
0.345 |
|
| 1994 |
Gerson SL, Zaidi NH, Dumenco LL, Allay E, Fan CY, Liu L, O'Connor PJ. Alkyltransferase transgenic mice: probes of chemical carcinogenesis. Mutation Research. 307: 541-55. PMID 7514728 DOI: 10.1016/0027-5107(94)90265-8 |
0.366 |
|
| 1993 |
Gerson SL, Zborowska E, Norton K, Gordon NH, Willson JK. Synergistic efficacy of O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) in a human colon cancer xenograft completely resistant to BCNU alone. Biochemical Pharmacology. 45: 483-91. PMID 8435098 DOI: 10.1016/0006-2952(93)90086-C |
0.379 |
|
| 1993 |
Dumenco LL, Allay E, Norton K, Gerson SL. The prevention of thymic lymphomas in transgenic mice by human O6-alkylguanine-DNA alkyltransferase. Science (New York, N.Y.). 259: 219-22. PMID 8421782 DOI: 10.1126/Science.8421782 |
0.362 |
|
| 1992 |
Gerson SL, Berger NA, Arce C, Petzold SJ, Willson JK. Modulation of nitrosourea resistance in human colon cancer by O6-methylguanine. Biochemical Pharmacology. 43: 1101-7. PMID 1554383 DOI: 10.1016/0006-2952(92)90618-S |
0.36 |
|
| 1992 |
Gerson SL, Meltzer H. Mechanisms of clozapine-induced agranulocytosis. Drug Safety. 7: 17-25. PMID 1503673 DOI: 10.2165/00002018-199200071-00007 |
0.328 |
|
| 1991 |
Dolan ME, Pegg AE, Dumenco LL, Moschel RC, Gerson SL. Comparison of the inactivation of mammalian and bacterial O6-alkylguanine-DNA alkyltransferases by O6-benzylguanine and O6-methylguanine. Carcinogenesis. 12: 2305-9. PMID 1747932 DOI: 10.1093/Carcin/12.12.2305 |
0.33 |
|
| 1990 |
Lim IK, Dumenco LL, Hatzoglou M, Hanson RW, Gerson SL. Increased drug resistance following retroviral gene transfer of a chimeric P-enolpyruvate carboxykinase (GTP)-bacterial O6-alkylguanine-DNA alkyltransferase gene into NRK cells. Carcinogenesis. 11: 737-43. PMID 2185901 DOI: 10.1093/Carcin/11.5.737 |
0.436 |
|
| 1989 |
Lazarus HM, Creger RJ, Gerson SL. Infectious emergencies in oncology patients. Seminars in Oncology. 16: 543-560. DOI: 10.5555/Uri:Pii:0093775489900328 |
0.301 |
|
| 1988 |
Hull CC, Galloway P, Gordon N, Gerson SL, Hawkins N, Stellato TA. Splenectomy and the induction of murine colon cancer. Archives of Surgery (Chicago, Ill. : 1960). 123: 462-4. PMID 3348737 DOI: 10.1001/Archsurg.1988.01400280072012 |
0.307 |
|
| 1988 |
Gerson S, Trey J. Modulation of nitrosourea resistance in myeloid leukemias Blood. 71: 1487-1494. DOI: 10.1182/blood.V71.5.1487.bloodjournal7151487 |
0.333 |
|
| 1988 |
Gerson S, Trey J. Modulation of nitrosourea resistance in myeloid leukemias Blood. 71: 1487-1494. DOI: 10.1182/blood.v71.5.1487.1487 |
0.333 |
|
| 1987 |
Abboud SL, Gerson SL, Berger NA. The effect of tumor necrosis factor on normal human hematopoietic progenitors. Cancer. 60: 2965-70. PMID 3677020 DOI: 10.1002/1097-0142(19871215)60:12<2965::Aid-Cncr2820601219>3.0.Co;2-O |
0.339 |
|
| 1986 |
Gerson SL, Trey JE, Miller K, Berger NA. Comparison of O6-alkylguanine-DNA alkyltransferase activity based on cellular DNA content in human, rat and mouse tissues. Carcinogenesis. 7: 745-9. PMID 3698202 DOI: 10.1093/Carcin/7.5.745 |
0.319 |
|
| 1985 |
Gerson SL, Miller K, Berger NA. O6 alkylguanine-DNA alkyltransferase activity in human myeloid cells. The Journal of Clinical Investigation. 76: 2106-14. PMID 3878366 DOI: 10.1172/Jci112215 |
0.377 |
|
| 1984 |
Cassileth PA, Gerson SL, Bonner H, Neiman RS, Lusk EJ, Hurwitz S. Identification of early relapsing patients with adult acute nonlymphocytic leukemia by bone marrow biopsy after initial induction chemotherapy. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 2: 107-11. PMID 6699661 DOI: 10.1200/Jco.1984.2.2.107 |
0.329 |
|
| 1984 |
Gerson SL, Cooper RA. Myelopoiesis following phorbol ester exposure in human long-term bone marrow cell culture. Leukemia Research. 8: 791-800. PMID 6333563 DOI: 10.1016/0145-2126(84)90100-0 |
0.356 |
|
| 1984 |
Gerson S, Cooper R. Release of granulocyte-specific colony-stimulating activity by human bone marrow exposed to phorbol esters Blood. 63: 878-885. DOI: 10.1182/Blood.V63.4.878.878 |
0.336 |
|
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