| Year |
Citation |
Score |
| 2020 |
Fan BZ, Hiasa H, Lv W, Brody S, Yang ZY, Aldrich C, Cushman M, Liang JH. Design, synthesis and structure-activity relationships of novel 15-membered macrolides: Quinolone/quinoline-containing sidechains tethered to the C-6 position of azithromycin acylides. European Journal of Medicinal Chemistry. 193: 112222. PMID 32200200 DOI: 10.1016/J.Ejmech.2020.112222 |
0.386 |
|
| 2019 |
Reguera RM, Álvarez-Velilla R, Domínguez-Asenjo B, Gutiérrez-Corbo C, Balaña-Fouce R, Cushman M, Pérez-Pertejo Y. Antiparasitic effect of synthetic aromathecins on Leishmania infantum. Bmc Veterinary Research. 15: 405. PMID 31706354 DOI: 10.1186/S12917-019-2153-9 |
0.349 |
|
| 2019 |
Gutiérrez-Corbo C, Álvarez-Velilla R, Reguera RM, García-Estrada C, Cushman M, Balaña-Fouce R, Pérez-Pertejo Y. Topoisomerase IB poisons induce histone H2A phosphorylation as a response to DNA damage in Leishmania infantum. International Journal For Parasitology. Drugs and Drug Resistance. 11: 39-48. PMID 31563118 DOI: 10.1016/J.Ijpddr.2019.09.005 |
0.343 |
|
| 2019 |
Wang KB, Elsayed MSA, Wu G, Deng N, Cushman M, Yang D. Indenoisoquinoline Topoisomerase Inhibitors Strongly Bind and Stabilize the MYC Promoter G-Quadruplex and Downregulate MYC. Journal of the American Chemical Society. PMID 31283877 DOI: 10.1021/Jacs.9B02679 |
0.396 |
|
| 2019 |
Li XM, Lv W, Guo SY, Li YX, Fan BZ, Cushman M, Kong FS, Zhang J, Liang JH. Synthesis and structure-bactericidal activity relationships of non-ketolides: 9-Oxime clarithromycin 11,12-cyclic carbonate featured with three-to eight-atom-length spacers at 3-OH. European Journal of Medicinal Chemistry. 171: 235-254. PMID 30925339 DOI: 10.1016/J.Ejmech.2019.03.037 |
0.321 |
|
| 2019 |
Ma CX, Lv W, Li YX, Fan BZ, Han X, Kong FS, Tian JC, Cushman M, Liang JH. Design, synthesis and structure-activity relationships of novel macrolones: Hybrids of 2-fluoro 9-oxime ketolides and carbamoyl quinolones with highly improved activity against resistant pathogens. European Journal of Medicinal Chemistry. 169: 1-20. PMID 30852383 DOI: 10.1016/J.Ejmech.2019.02.073 |
0.324 |
|
| 2018 |
Pommier Y, Cushman M, Doroshow JH. Novel clinical indenoisoquinoline topoisomerase I inhibitors: a twist around the camptothecins. Oncotarget. 9: 37286-37288. PMID 30647868 DOI: 10.18632/Oncotarget.26466 |
0.309 |
|
| 2018 |
Elsayed MSA, Nielsen JJ, Park S, Park J, Liu Q, Kim CH, Pommier Y, Agama K, Low PS, Cushman M. Application of Sequential Palladium Catalysis for the Discovery of Janus Kinase Inhibitors in the Benzo[ c]pyrrolo[2,3- h][1,6]naphthyridin-5-one (BPN) Series. Journal of Medicinal Chemistry. PMID 30460842 DOI: 10.1021/Acs.Jmedchem.8B00510 |
0.409 |
|
| 2018 |
Lee HM, Clark EP, Kuijer MB, Cushman M, Pommier Y, Philpot BD. Characterization and structure-activity relationships of indenoisoquinoline-derived topoisomerase I inhibitors in unsilencing the dormant gene associated with Angelman syndrome. Molecular Autism. 9: 45. PMID 30140420 DOI: 10.1186/S13229-018-0228-2 |
0.32 |
|
| 2018 |
Nenortas NP, Cinelli MA, Morrell AE, Cushman M, Shapiro TA. Activity of aromathecins against African trypanosomes. Antimicrobial Agents and Chemotherapy. PMID 30104277 DOI: 10.1128/Aac.00786-18 |
0.75 |
|
| 2018 |
Marzi L, Agama K, Murai J, Difilippantonio S, James A, Peer CJ, Figg WD, Beck D, Elsayed MSA, Cushman M, Pommier Y. Novel fluoroindenoisoquinoline non-camptothecin topoisomerase I inhibitors. Molecular Cancer Therapeutics. PMID 29748210 DOI: 10.1158/1535-7163.Mct-18-0028 |
0.397 |
|
| 2018 |
Elsayed MSA, Chang S, Cushman M. Ligand-free, palladacycle-facilitated Suzuki coupling of hindered 2-arylbenzothiazole derivatives yields potent and selective COX-2 inhibitors Organic and Biomolecular Chemistry. 16: 108-118. PMID 29199735 DOI: 10.1039/C7Ob02386C |
0.399 |
|
| 2018 |
Pommier Y, Marzi L, Ohler ZW, Szabova L, Sharan S, Murai J, Cushman M. Abstract 4855: Indotecan (LMP400), Imidotecan (LMP776) and LMP744: A new class of non-camptothecin TOP1 inhibitors selective for cancer cells with homologous recombination deficiencies and high SLFN11 expression Cancer Research. 78: 4855-4855. DOI: 10.1158/1538-7445.Am2018-4855 |
0.339 |
|
| 2018 |
Wang K, Elsayed MSA, Wu G, Cushman M, Yang D. Abstract 2662: Indenoisoquinoline topoisomerase I inhibitors target the DNA G-quadruplex formed in the c-Myc promoter and cause MYC downregulation Cancer Research. 78: 2662-2662. DOI: 10.1158/1538-7445.Am2018-2662 |
0.415 |
|
| 2017 |
Elsayed MSA, Su Y, Wang P, Sethi T, Agama K, Ravji A, Redon CE, Kiselev E, Horzmann KA, Freeman JL, Pommier Y, Cushman M. Design and Synthesis of Chlorinated and Fluorinated 7-Azaindenoisoquinolines as Potent Cytotoxic Anticancer Agents That Inhibit Topoisomerase I. Journal of Medicinal Chemistry. PMID 28657311 DOI: 10.1021/Acs.Jmedchem.6B01870 |
0.465 |
|
| 2017 |
Liang JH, Yang L, Wu S, Liu SS, Cushman M, Tian J, Li NM, Yang QH, Zhang HA, Qiu YJ, Xiang L, Ma CX, Li XM, Qing H. Discovery of efficient stimulators for adult hippocampal neurogenesis based on scaffolds in dragon's blood. European Journal of Medicinal Chemistry. 136: 382-392. PMID 28525839 DOI: 10.1016/J.Ejmech.2017.05.025 |
0.317 |
|
| 2017 |
Wang P, Elsayed MSA, Plescia CB, Ravji A, Redon CE, Kiselev E, Marchand C, Zeleznik O, Agama K, Pommier Y, Cushman M. Synthesis and Biological Evaluation of the First Triple Inhibitors of Human Topoisomerase 1, Tyrosyl-DNA Phosphodiesterase 1 (Tdp1), and Tyrosyl-DNA Phosphodiesterase 2 (Tdp2). Journal of Medicinal Chemistry. PMID 28418653 DOI: 10.1021/Acs.Jmedchem.6B01565 |
0.407 |
|
| 2017 |
Mohammad H, Younis W, Chen L, Peters CE, Pogliano J, Pogliano K, Cooper BR, Zhang J, Mayhoub AS, Oldfield E, Cushman MS, Seleem MN. Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity In Vitro and In Vivo against Vancomycin-resistant Enterococci. Journal of Medicinal Chemistry. PMID 28248504 DOI: 10.1021/Acs.Jmedchem.6B01780 |
0.403 |
|
| 2017 |
Coyne GHO, Kummar S, Meehan RS, Streicher H, Takebe N, Sharon E, Conley BA, Harris L, Collins JM, Moore N, Juwara L, Rubinstein L, Quinn MF, Pommier Y, Cushman M, et al. Phase I study of indenoisoquinolines LMP776 in adults with relapsed solid tumors and lymphomas. Journal of Clinical Oncology. 35: 2558-2558. DOI: 10.1200/Jco.2017.35.15_Suppl.2558 |
0.334 |
|
| 2016 |
Elsayed MSA, Zeller M, Cushman M. Synthesis of indolo[4,3-bc]phenanthridine-6,11(2H,12H)-diones using the Schiff base-homophthalic anhydride cyclization reaction. Synthetic Communications. 46: 1902-1908. PMID 29056779 DOI: 10.1080/00397911.2016.1232409 |
0.395 |
|
| 2016 |
Zhao LM, Jin HS, Liu J, Skaar TC, Ipe J, Lv W, Flockhart DA, Cushman M. A new Suzuki synthesis of triphenylethylenes that inhibit aromatase and bind to estrogen receptors α and β. Bioorganic & Medicinal Chemistry. PMID 27647367 DOI: 10.1016/J.Bmc.2016.08.064 |
0.407 |
|
| 2016 |
Hoshi A, Sakamoto T, Takayama J, Xuan M, Okazaki M, Hartman TL, Buckheit RW, Pannecouque C, Cushman M. Systematic evaluation of methyl ester bioisosteres in the context of developing alkenyldiarylmethanes (ADAMs) as non-nucleoside reverse transcriptase inhibitors (NNRTIs) for anti-HIV-1 chemotherapy. Bioorganic & Medicinal Chemistry. PMID 27234889 DOI: 10.1016/J.Bmc.2016.05.010 |
0.418 |
|
| 2016 |
Lv PC, Elsayed MS, Agama K, Marchand C, Pommier Y, Cushman M. Design, Synthesis, and Biological Evaluation of Potential Prodrugs Related to the Experimental Anticancer Agent Indotecan (LMP400). Journal of Medicinal Chemistry. PMID 27097152 DOI: 10.1021/Acs.Jmedchem.6B00220 |
0.462 |
|
| 2016 |
Beck DE, Reddy PV, Lv W, Abdelmalak M, Tender GS, Lopez S, Agama K, Marchand C, Pommier Y, Cushman M. Investigation of the Structure-Activity Relationships of Aza-A-Ring Indenoisoquinoline Topoisomerase I Poisons. Journal of Medicinal Chemistry. PMID 27070999 DOI: 10.1021/Acs.Jmedchem.6B00003 |
0.432 |
|
| 2016 |
Beck DE, Lv W, Abdelmalak M, Plescia CB, Agama K, Marchand C, Pommier Y, Cushman M. Synthesis and biological evaluation of new fluorinated and chlorinated indenoisoquinoline topoisomerase I poisons. Bioorganic & Medicinal Chemistry. 24: 1469-79. PMID 26906474 DOI: 10.1016/J.Bmc.2016.02.015 |
0.457 |
|
| 2016 |
Lv W, Liu J, Skaar TC, O'Neill E, Yu G, Flockhart DA, Cushman M. Synthesis of Triphenylethylene Bisphenols as Aromatase Inhibitors That Also Modulate Estrogen Receptors. Journal of Medicinal Chemistry. 59: 157-70. PMID 26704594 DOI: 10.1021/Acs.Jmedchem.5B01677 |
0.312 |
|
| 2016 |
Steinhauer TN, Girreser U, Meier C, Cushman M, Clement B. One-Step Synthetic Access to Isosteric and Potent Anticancer Nitrogen Heterocycles with the Benzo[c]phenanthridine Scaffold Chemistry - a European Journal. DOI: 10.1002/Chem.201600308 |
0.347 |
|
| 2015 |
Han X, Lv W, Guo SY, Cushman M, Liang JH. Synthesis and structure-activity relationships of novel 9-oxime acylides with improved bactericidal activity. Bioorganic & Medicinal Chemistry. PMID 26349628 DOI: 10.1016/J.Bmc.2015.08.020 |
0.375 |
|
| 2015 |
Mohammad H, Reddy PV, Monteleone D, Mayhoub AS, Cushman M, Hammac GK, Seleem MN. Antibacterial Characterization of Novel Synthetic Thiazole Compounds against Methicillin-Resistant Staphylococcus pseudintermedius. Plos One. 10: e0130385. PMID 26086336 DOI: 10.1371/Journal.Pone.0130385 |
0.389 |
|
| 2015 |
Beck DE, Abdelmalak M, Lv W, Reddy PV, Tender GS, O'Neill E, Agama K, Marchand C, Pommier Y, Cushman M. Discovery of potent indenoisoquinoline topoisomerase I poisons lacking the 3-nitro toxicophore. Journal of Medicinal Chemistry. 58: 3997-4015. PMID 25909279 DOI: 10.1021/Acs.Jmedchem.5B00303 |
0.411 |
|
| 2015 |
Roy J, Nguyen TX, Kanduluru AK, Venkatesh C, Lv W, Reddy PV, Low PS, Cushman M. DUPA conjugation of a cytotoxic indenoisoquinoline topoisomerase I inhibitor for selective prostate cancer cell targeting. Journal of Medicinal Chemistry. 58: 3094-103. PMID 25822623 DOI: 10.1021/Jm5018384 |
0.307 |
|
| 2015 |
Nguyen TX, Abdelmalak M, Marchand C, Agama K, Pommier Y, Cushman M. Synthesis and biological evaluation of nitrated 7-, 8-, 9-, and 10-hydroxyindenoisoquinolines as potential dual topoisomerase I (Top1)-tyrosyl-DNA phosphodiesterase I (TDP1) inhibitors. Journal of Medicinal Chemistry. 58: 3188-208. PMID 25811317 DOI: 10.1021/Acs.Jmedchem.5B00136 |
0.461 |
|
| 2015 |
Mohammad H, Reddy PV, Monteleone D, Mayhoub AS, Cushman M, Seleem MN. Synthesis and antibacterial evaluation of a novel series of synthetic phenylthiazole compounds against methicillin-resistant Staphylococcus aureus (MRSA). European Journal of Medicinal Chemistry. 94: 306-16. PMID 25771109 DOI: 10.1016/J.Ejmech.2015.03.015 |
0.395 |
|
| 2015 |
Lv W, Liu J, Skaar TC, Flockhart DA, Cushman M. Design and synthesis of norendoxifen analogues with dual aromatase inhibitory and estrogen receptor modulatory activities. Journal of Medicinal Chemistry. 58: 2623-48. PMID 25751283 DOI: 10.1021/Jm501218E |
0.377 |
|
| 2015 |
Mohammad H, Mayhoub AS, Cushman M, Seleem MN. Anti-biofilm activity and synergism of novel thiazole compounds with glycopeptide antibiotics against multidrug-resistant Staphylococci The Journal of Antibiotics. 68: 259-266. PMID 25315757 DOI: 10.1038/Ja.2014.142 |
0.315 |
|
| 2015 |
Stenvang J, Jensen NF, Jandu H, Knudsen S, Agama K, Jensen T, Hansen A, Jensen PB, Pommier Y, Cushman M, Brünner N. Abstract A182: Targeting the topoisomerase I enzyme in cancer cells with acquired resistance to SN-38 Molecular Cancer Therapeutics. 14. DOI: 10.1158/1535-7163.Targ-15-A182 |
0.314 |
|
| 2014 |
Cushman M, Georg GI, Holzgrabe U, Wang S. Absolute quantitative (1)h NMR spectroscopy for compound purity determination. Journal of Medicinal Chemistry. 57: 9219. PMID 25380231 DOI: 10.1021/Jm501683W |
0.305 |
|
| 2014 |
Li J, Pan L, Fletcher JN, Lv W, Deng Y, Vincent MA, Slack JP, McCluskey TS, Jia Z, Cushman M, Kinghorn AD. In vitro evaluation of potential bitterness-masking terpenoids from the Canada goldenrod (Solidago canadensis). Journal of Natural Products. 77: 1739-43. PMID 24999828 DOI: 10.1021/Np5001413 |
0.339 |
|
| 2014 |
Lv P, Agama K, Marchand C, Pommier Y, Cushman M. Design, synthesis, and biological evaluation of O-2-modified indenoisoquinolines as dual topoisomerase I-tyrosyl-DNA phosphodiesterase I inhibitors. Journal of Medicinal Chemistry. 57: 4324-4336. PMID 24800942 DOI: 10.1021/Jm500294A |
0.448 |
|
| 2014 |
Beck DE, Agama K, Marchand C, Chergui A, Pommier Y, Cushman M. Synthesis and biological evaluation of new carbohydrate-substituted indenoisoquinoline topoisomerase I inhibitors and improved syntheses of the experimental anticancer agents indotecan (LMP400) and indimitecan (LMP776) Journal of Medicinal Chemistry. 57: 1495-1512. PMID 24517248 DOI: 10.1021/Jm401814Y |
0.468 |
|
| 2014 |
Kiselev E, Sooryakumar D, Agama K, Cushman M, Pommier Y. Optimization of the lactam side chain of 7-azaindenoisoquinoline topoisomerase I inhibitors and mechanism of action studies in cancer cells. Journal of Medicinal Chemistry. 57: 1289-1298. PMID 24502276 DOI: 10.1021/Jm401471V |
0.382 |
|
| 2014 |
Lv W, Banerjee B, Molland KL, Seleem MN, Ghafoor A, Hamed MI, Wan B, Franzblau SG, Mesecar AD, Cushman M. Synthesis of 3-(3-aryl-pyrrolidin-1-yl)-5-aryl-1,2,4-triazines that have antibacterial activity and also inhibit inorganic pyrophosphatase. Bioorganic & Medicinal Chemistry. 22: 406-18. PMID 24315189 DOI: 10.1016/J.Bmc.2013.11.011 |
0.44 |
|
| 2013 |
Liu J, Flockhart PJ, Lu D, Lv W, Lu WJ, Han X, Cushman M, Flockhart DA. Inhibition of cytochrome p450 enzymes by the e- and z-isomers of norendoxifen. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 41: 1715-20. PMID 23824607 DOI: 10.1124/Dmd.113.052506 |
0.328 |
|
| 2013 |
Conda-Sheridan M, Park EJ, Beck DE, Reddy PV, Nguyen TX, Hu B, Chen L, White JJ, van Breemen RB, Pezzuto JM, Cushman M. Design, synthesis, and biological evaluation of indenoisoquinoline rexinoids with chemopreventive potential. Journal of Medicinal Chemistry. 56: 2581-605. PMID 23472886 DOI: 10.1021/Jm400026K |
0.701 |
|
| 2013 |
Liang JH, Lv W, Li XL, An K, Cushman M, Wang H, Xu YC. Synthesis and antibacterial activity of 9-oxime ether non-ketolides, and novel binding mode of alkylides with bacterial rRNA. Bioorganic & Medicinal Chemistry Letters. 23: 1387-93. PMID 23375796 DOI: 10.1016/J.Bmcl.2012.12.070 |
0.323 |
|
| 2013 |
Conda-Sheridan M, Reddy PV, Morrell A, Cobb BT, Marchand C, Agama K, Chergui A, Renaud A, Stephen AG, Bindu LK, Pommier Y, Cushman M. Synthesis and biological evaluation of indenoisoquinolines that inhibit both tyrosyl-DNA phosphodiesterase I (Tdp1) and topoisomerase I (Top1). Journal of Medicinal Chemistry. 56: 182-200. PMID 23259865 DOI: 10.1021/Jm3014458 |
0.737 |
|
| 2013 |
Liang JH, An K, Lv W, Cushman M, Wang H, Xu YC. Synthesis, antibacterial activity and docking of 14-membered 9-O-(3-arylalkyl) oxime 11,12-cyclic carbonate ketolides. European Journal of Medicinal Chemistry. 59: 54-63. PMID 23202851 DOI: 10.1016/J.Ejmech.2012.10.054 |
0.307 |
|
| 2012 |
Cinelli MA, Reddy PV, Lv PC, Liang JH, Chen L, Agama K, Pommier Y, van Breemen RB, Cushman M. Identification, synthesis, and biological evaluation of metabolites of the experimental cancer treatment drugs indotecan (LMP400) and indimitecan (LMP776) and investigation of isomerically hydroxylated indenoisoquinoline analogues as topoisomerase I poisons. Journal of Medicinal Chemistry. 55: 10844-62. PMID 23215354 DOI: 10.1021/Jm300519W |
0.766 |
|
| 2012 |
Mayhoub AS, Marler L, Kondratyuk TP, Park EJ, Pezzuto JM, Cushman M. Optimization of thiazole analogues of resveratrol for induction of NAD(P)H:quinone reductase 1 (QR1). Bioorganic & Medicinal Chemistry. 20: 7030-9. PMID 23142320 DOI: 10.1016/J.Bmc.2012.10.006 |
0.375 |
|
| 2012 |
Nguyen TX, Morrell A, Conda-Sheridan M, Marchand C, Agama K, Bermingham A, Stephen AG, Chergui A, Naumova A, Fisher R, O'Keefe BR, Pommier Y, Cushman M. Correction to Synthesis and Biological Evaluation of the First Dual Tyrosyl-DNA Phosphodiesterase I (Tdp1)-Topoisomerase I (Top1) Inhibitors. Journal of Medicinal Chemistry. 55: 7297. PMID 22891611 DOI: 10.1021/Jm301167V |
0.707 |
|
| 2012 |
Balaña-Fouce R, Prada CF, Requena JM, Cushman M, Pommier Y, Ãlvarez-Velilla R, Escudero-MartÃnez JM, Calvo-Ãlvarez E, Pérez-Pertejo Y, Reguera RM. Indotecan (LMP400) and AM13-55: two novel indenoisoquinolines show potential for treating visceral leishmaniasis. Antimicrobial Agents and Chemotherapy. 56: 5264-70. PMID 22850521 DOI: 10.1128/Aac.00499-12 |
0.362 |
|
| 2012 |
Sun D, Hurdle JG, Lee R, Lee R, Cushman M, Pezzuto JM. Evaluation of flavonoid and resveratrol chemical libraries reveals abyssinone II as a promising antibacterial lead. Chemmedchem. 7: 1541-5. PMID 22847956 DOI: 10.1002/Cmdc.201200253 |
0.313 |
|
| 2012 |
Talukdar A, Zhao Y, Lv W, Bacher A, Illarionov B, Fischer M, Cushman M. O-nucleoside, S-nucleoside, and N-nucleoside probes of lumazine synthase and riboflavin synthase Journal of Organic Chemistry. 77: 6239-6261. PMID 22780198 DOI: 10.1021/Jo3010364 |
0.378 |
|
| 2012 |
Chen L, Conda-Sheridan M, Reddy PV, Morrell A, Park EJ, Kondratyuk TP, Pezzuto JM, van Breemen RB, Cushman M. Identification, synthesis, and biological evaluation of the metabolites of 3-amino-6-(3'-aminopropyl)-5H-indeno[1,2-c]isoquinoline-5,11-(6H)dione (AM6-36), a promising rexinoid lead compound for the development of cancer chemotherapeutic and chemopreventive agents. Journal of Medicinal Chemistry. 55: 5965-81. PMID 22712432 DOI: 10.1021/Jm3006806 |
0.698 |
|
| 2012 |
Kiselev E, Empey N, Agama K, Pommier Y, Cushman M. Dibenzo[c,h][1,5]naphthyridinediones as topoisomerase I inhibitors: design, synthesis, and biological evaluation. The Journal of Organic Chemistry. 77: 5167-72. PMID 22587603 DOI: 10.1021/Jo3006039 |
0.372 |
|
| 2012 |
Nguyen TX, Morrell A, Conda-Sheridan M, Marchand C, Agama K, Bermingham A, Bermingam A, Stephen AG, Chergui A, Naumova A, Fisher R, O'Keefe BR, Pommier Y, Cushman M. Synthesis and biological evaluation of the first dual tyrosyl-DNA phosphodiesterase I (Tdp1)-topoisomerase I (Top1) inhibitors. Journal of Medicinal Chemistry. 55: 4457-78. PMID 22536944 DOI: 10.1021/Jm300335N |
0.739 |
|
| 2012 |
Mayhoub AS, Marler L, Kondratyuk TP, Park EJ, Pezzuto JM, Cushman M. Optimization of the aromatase inhibitory activities of pyridylthiazole analogues of resveratrol. Bioorganic & Medicinal Chemistry. 20: 2427-34. PMID 22386564 DOI: 10.1016/J.Bmc.2012.01.047 |
0.381 |
|
| 2012 |
Kiselev E, Agama K, Pommier Y, Cushman M. Azaindenoisoquinolines as Topoisomerase I Inhibitors and Potential Anticancer Agents: A Systematic Study of Structure-Activity Relationships Journal of Medicinal Chemistry. 55: 1682-1697. PMID 22329436 DOI: 10.1021/Jm201512X |
0.417 |
|
| 2012 |
Reddy PV, Jensen KC, Mesecar AD, Fanwick PE, Cushman M. Design, synthesis, and biological evaluation of potent quinoline and pyrroloquinoline ammosamide analogues as inhibitors of quinone reductase 2. Journal of Medicinal Chemistry. 55: 367-77. PMID 22206487 DOI: 10.1021/Jm201251C |
0.399 |
|
| 2012 |
Park EJ, Kiselev E, Conda-Sheridan M, Cushman M, Pezzuto JM. Induction of apoptosis by 3-amino-6-(3-aminopropyl)-5,6-dihydro-5,11-dioxo-11H-indeno[1,2-c]isoquinoline via modulation of MAPKs (p38 and c-Jun N-terminal kinase) and c-Myc in HL-60 human leukemia cells. Journal of Natural Products. 75: 378-84. PMID 22148260 DOI: 10.1021/Np200791J |
0.694 |
|
| 2012 |
Mayhoub AS, Marler L, Kondratyuk TP, Park EJ, Pezzuto JM, Cushman M. Optimizing thiadiazole analogues of resveratrol versus three chemopreventive targets. Bioorganic & Medicinal Chemistry. 20: 510-20. PMID 22115839 DOI: 10.1016/J.Bmc.2011.09.031 |
0.383 |
|
| 2012 |
Lu WJ, Xu C, Pei Z, Mayhoub AS, Cushman M, Flockhart DA. The tamoxifen metabolite norendoxifen is a potent and selective inhibitor of aromatase (CYP19) and a potential lead compound for novel therapeutic agents. Breast Cancer Research and Treatment. 133: 99-109. PMID 21814747 DOI: 10.1007/S10549-011-1699-4 |
0.43 |
|
| 2012 |
Park E, Morrell A, Conda-Sheridan M, Cushman M, Pezzuto JM. Abstract 1934: Characterization of the anti-proliferative effect of 6-(3-aminopropyl)-9-methoxy-3-nitro-5H-indeno[1,2-c]isoquinoline-5,11(6H)-dione in cultured PC-3 cells Cancer Research. 72: 1934-1934. DOI: 10.1158/1538-7445.Am2012-1934 |
0.694 |
|
| 2012 |
Luqman S, Kondratyuk TP, Hosino J, Cushman M, Pezzuto JM. Suppression of 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase activity by resveratrol derivatives Nature Precedings. 7: 1-1. DOI: 10.1038/Npre.2012.6908.1 |
0.322 |
|
| 2011 |
Kiselev E, DeGuire S, Morrell A, Agama K, Dexheimer TS, Pommier Y, Cushman M. 7-azaindenoisoquinolines as topoisomerase I inhibitors and potential anticancer agents. Journal of Medicinal Chemistry. 54: 6106-16. PMID 21823606 DOI: 10.1021/Jm200719V |
0.353 |
|
| 2011 |
Kondratyuk TP, Park EJ, Marler LE, Ahn S, Yuan Y, Choi Y, Yu R, van Breemen RB, Sun B, Hoshino J, Cushman M, Jermihov KC, Mesecar AD, Grubbs CJ, Pezzuto JM. Resveratrol derivatives as promising chemopreventive agents with improved potency and selectivity. Molecular Nutrition & Food Research. 55: 1249-65. PMID 21714126 DOI: 10.1002/Mnfr.201100122 |
0.316 |
|
| 2011 |
Peterson KE, Cinelli MA, Morrell AE, Mehta A, Dexheimer TS, Agama K, Antony S, Pommier Y, Cushman M. Alcohol-, diol-, and carbohydrate-substituted indenoisoquinolines as topoisomerase I inhibitors: investigating the relationships involving stereochemistry, hydrogen bonding, and biological activity. Journal of Medicinal Chemistry. 54: 4937-53. PMID 21710981 DOI: 10.1021/Jm101338Z |
0.767 |
|
| 2011 |
Mayhoub AS, Khaliq M, Botting C, Li Z, Kuhn RJ, Cushman M. An investigation of phenylthiazole antiflaviviral agents. Bioorganic & Medicinal Chemistry. 19: 3845-54. PMID 21612931 DOI: 10.1016/J.Bmc.2011.04.041 |
0.404 |
|
| 2011 |
Park EJ, Kondratyuk TP, Morrell A, Kiselev E, Conda-Sheridan M, Cushman M, Ahn S, Choi Y, White JJ, van Breemen RB, Pezzuto JM. Induction of retinoid X receptor activity and consequent upregulation of p21WAF1/CIP1 by indenoisoquinolines in MCF7 cells. Cancer Prevention Research (Philadelphia, Pa.). 4: 592-607. PMID 21464033 DOI: 10.1158/1940-6207.Capr-10-0004 |
0.695 |
|
| 2011 |
Mayhoub AS, Khaliq M, Kuhn RJ, Cushman M. Design, synthesis, and biological evaluation of thiazoles targeting flavivirus envelope proteins. Journal of Medicinal Chemistry. 54: 1704-14. PMID 21355607 DOI: 10.1021/Jm1013538 |
0.422 |
|
| 2010 |
Marler L, Conda-Sheridan M, Cinelli MA, Morrell AE, Cushman M, Chen L, Huang K, Van Breemen R, Pezzuto JM. Cancer chemopreventive potential of aromathecins and phenazines, novel natural product derivatives. Anticancer Research. 30: 4873-82. PMID 21187465 |
0.799 |
|
| 2010 |
Conda-Sheridan M, Marler L, Park EJ, Kondratyuk TP, Jermihov K, Mesecar AD, Pezzuto JM, Asolkar RN, Fenical W, Cushman M. Potential chemopreventive agents based on the structure of the lead compound 2-bromo-1-hydroxyphenazine, isolated from Streptomyces species, strain CNS284. Journal of Medicinal Chemistry. 53: 8688-99. PMID 21105712 DOI: 10.1021/Jm1011066 |
0.712 |
|
| 2010 |
Kiselev E, Dexheimer TS, Pommier Y, Cushman M. Design, synthesis, and evaluation of dibenzo[c,h][1,6]naphthyridines as topoisomerase I inhibitors and potential anticancer agents. Journal of Medicinal Chemistry. 53: 8716-26. PMID 21090809 DOI: 10.1021/Jm101048K |
0.468 |
|
| 2010 |
Morgunova E, Illarionov B, Saller S, Popov A, Sambaiah T, Bacher A, Cushman M, Fischer M, Ladenstein R. Structural study and thermodynamic characterization of inhibitor binding to lumazine synthase from Bacillus anthracis Acta Crystallographica Section D: Biological Crystallography. 66: 1001-1011. PMID 20823551 DOI: 10.1107/S0907444910029690 |
0.347 |
|
| 2010 |
Cinelli MA, Morrell AE, Dexheimer TS, Agama K, Agrawal S, Pommier Y, Cushman M. The structure-activity relationships of A-ring-substituted aromathecin topoisomerase I inhibitors strongly support a camptothecin-like binding mode. Bioorganic & Medicinal Chemistry. 18: 5535-52. PMID 20630766 DOI: 10.1016/J.Bmc.2010.06.040 |
0.771 |
|
| 2010 |
Sun B, Hoshino J, Jermihov K, Marler L, Pezzuto JM, Mesecar AD, Cushman M. Design, synthesis, and biological evaluation of resveratrol analogues as aromatase and quinone reductase 2 inhibitors for chemoprevention of cancer. Bioorganic & Medicinal Chemistry. 18: 5352-66. PMID 20558073 DOI: 10.1016/J.Bmc.2010.05.042 |
0.422 |
|
| 2010 |
Hoshino J, Park EJ, Kondratyuk TP, Marler L, Pezzuto JM, van Breemen RB, Mo S, Li Y, Cushman M. Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites. Journal of Medicinal Chemistry. 53: 5033-43. PMID 20527891 DOI: 10.1021/Jm100274C |
0.379 |
|
| 2010 |
Reddy PVN, Banerjee B, Cushman M. Efficient total synthesis of ammosamide B. Organic Letters. 12: 3112-3114. PMID 20515072 DOI: 10.1021/Ol101215X |
0.348 |
|
| 2010 |
Talukdar A, Morgunova E, Duan J, Meining W, Foloppe N, Nilsson L, Bacher A, Illarionov B, Fischer M, Ladenstein R, Cushman M. Virtual screening, selection and development of a benzindolone structural scaffold for inhibition of lumazine synthase. Bioorganic & Medicinal Chemistry. 18: 3518-34. PMID 20430628 DOI: 10.1016/J.Bmc.2010.03.072 |
0.403 |
|
| 2010 |
Song Y, Shao Z, Dexheimer TS, Scher ES, Pommier Y, Cushman M. Structure-based design, synthesis, and biological studies of new anticancer norindenoisoquinoline topoisomerase I inhibitors. Journal of Medicinal Chemistry. 53: 1979-89. PMID 20155916 DOI: 10.1021/Jm901649X |
0.444 |
|
| 2010 |
Kim RR, Illarionov B, Joshi M, Cushman M, Lee CY, Eisenreich W, Fischer M, Bacher A. Mechanistic insights on riboflavin synthase inspired by selective binding of the 6,7-dimethyl-8-ribityllumazine exomethylene anion Journal of the American Chemical Society. 132: 2983-2990. PMID 20143812 DOI: 10.1021/Ja908395R |
0.311 |
|
| 2010 |
Park E, Kondratyuk T, Morrell A, Kiselev E, Cushman M, Pezzuto J. Abstract B91: Induction of RXR transcriptional activity and consequent upregulation of p21 by 3‐amino‐6‐(3‐aminopropyl)‐5,6‐dihydro‐5, 11‐dioxo‐11H‐indeno[1,2‐c]isoquinoline dihydrochloride in MCF‐7 breast cancer cells Cancer Prevention Research. 3. DOI: 10.1158/1940-6207.Prev-09-B91 |
0.344 |
|
| 2010 |
Marler LE, Cushman M, Sun B, Mesecar AD, Jermihov K, Breemen RBv, Pezzuto JM. Abstract A68: Aromatase inhibition and chemopreventive potential of novel resveratrol derivatives Cancer Prevention Research. 3. DOI: 10.1158/1940-6207.Prev-09-A68 |
0.432 |
|
| 2009 |
Cinelli MA, Cordero B, Dexheimer TS, Pommier Y, Cushman M. Synthesis and biological evaluation of 14-(aminoalkyl-aminomethyl)aromathecins as topoisomerase I inhibitors: investigating the hypothesis of shared structure-activity relationships. Bioorganic & Medicinal Chemistry. 17: 7145-55. PMID 19783447 DOI: 10.1016/J.Bmc.2009.08.066 |
0.772 |
|
| 2009 |
Cullen MD, Ho WC, Bauman JD, Das K, Arnold E, Hartman TL, Watson KM, Buckheit RW, Pannecouque C, De Clercq E, Cushman M. Crystallographic study of a novel subnanomolar inhibitor provides insight on the binding interactions of alkenyldiarylmethanes with human immunodeficiency virus-1 reverse transcriptase. Journal of Medicinal Chemistry. 52: 6467-73. PMID 19775161 DOI: 10.1021/Jm901167T |
0.385 |
|
| 2009 |
Talukdar A, Breen M, Bacher A, Illarionov B, Fischer M, Georg G, Ye QZ, Cushman M. Discovery and development of a small molecule library with lumazine synthase inhibitory activity Journal of Organic Chemistry. 74: 5123-5134. PMID 19552377 DOI: 10.1021/Jo900238Q |
0.366 |
|
| 2009 |
Zhao Y, Bacher A, Illarionov B, Fischer M, Georg G, Ye QZ, Fanwick PE, Franzblau SG, Wan B, Cushman M. Discovery and development of the covalent hydrates of trifluoromethylated pyrazoles as riboflavin synthase inhibitors with antibiotic activity against Mycobacterium tuberculosis Journal of Organic Chemistry. 74: 5297-5303. PMID 19545132 DOI: 10.1021/Jo900768C |
0.378 |
|
| 2009 |
Pommier Y, Cushman M. The indenoisoquinoline noncamptothecin topoisomerase I inhibitors: update and perspectives Molecular Cancer Therapeutics. 8: 1008-1014. PMID 19383846 DOI: 10.1158/1535-7163.Mct-08-0706 |
0.364 |
|
| 2009 |
Maiti A, Reddy PV, Sturdy M, Marler L, Pegan SD, Mesecar AD, Pezzuto JM, Cushman M. Synthesis of casimiroin and optimization of its quinone reductase 2 and aromatase inhibitory activities. Journal of Medicinal Chemistry. 52: 1873-84. PMID 19265439 DOI: 10.1021/Jm801335Z |
0.34 |
|
| 2009 |
Deng BL, Zhao Y, Hartman TL, Watson K, Buckheit RW, Pannecouque C, De Clercq E, Cushman M. Synthesis of alkenyldiarylmethanes (ADAMs) containing benzo[d]isoxazole and oxazolidin-2-one rings, a new series of potent non-nucleoside HIV-1 reverse transcriptase inhibitors. European Journal of Medicinal Chemistry. 44: 1210-4. PMID 18952324 DOI: 10.1016/J.Ejmech.2008.09.013 |
0.381 |
|
| 2009 |
Bakshi RP, Sang D, Morrell A, Cushman M, Shapiro TA. Activity of indenoisoquinolines against African trypanosomes. Antimicrobial Agents and Chemotherapy. 53: 123-8. PMID 18824603 DOI: 10.1128/Aac.00650-07 |
0.394 |
|
| 2009 |
Fang Z, Agoston GE, Ladouceur G, Treston AM, Wang L, Cushman M. Structure elucidation by synthesis of four metabolites of the antitumor drug ENMD-1198 detected in human plasma samples Tetrahedron. 65: 10535-10543. DOI: 10.1016/J.Tet.2009.10.046 |
0.347 |
|
| 2008 |
Yu TY, O'Connor RD, Sivertsen AC, Chiauzzi C, Poliks B, Fischer M, Bacher A, Haase I, Cushman M, Schaefer J. (15)N{(31)P} REDOR NMR studies of the binding of phosphonate reaction intermediate analogues to Saccharomyces cerevisiae lumazine synthase. Biochemistry. 47: 13942-51. PMID 19117095 DOI: 10.1021/Bi8015789 |
0.305 |
|
| 2008 |
Cinelli MA, Morrell A, Dexheimer TS, Scher ES, Pommier Y, Cushman M. Design, synthesis, and biological evaluation of 14-substituted aromathecins as topoisomerase I inhibitors. Journal of Medicinal Chemistry. 51: 4609-19. PMID 18630891 DOI: 10.1021/Jm800259E |
0.78 |
|
| 2008 |
Li Z, Khaliq M, Zhou Z, Post CB, Kuhn RJ, Cushman M. Design, synthesis, and biological evaluation of antiviral agents targeting flavivirus envelope proteins. Journal of Medicinal Chemistry. 51: 4660-71. PMID 18610998 DOI: 10.1021/Jm800412D |
0.384 |
|
| 2008 |
Fang Z, Song Y, Sarkar T, Hamel E, Fogler WE, Agoston GE, Fanwick PE, Cushman M. Stereoselective synthesis of 3,3-diarylacrylonitriles as tubulin polymerization inhibitors. The Journal of Organic Chemistry. 73: 4241-4. PMID 18447388 DOI: 10.1021/Jo800428B |
0.372 |
|
| 2008 |
Zhang Y, Illarionov B, Morgunova E, Jin G, Bacher A, Fischer M, Ladenstein R, Cushman M. A new series of N-[2,4-dioxo-6-D-ribitylamino-1,2,3,4-tetrahydropyrimidin- 5-yl]oxalamic acid derivatives as inhibitors of lumazine synthase and riboflavin synthase: Design, synthesis, biochemical evaluation, crystallography, and mechanistic implications Journal of Organic Chemistry. 73: 2715-2724. PMID 18331058 DOI: 10.1021/Jo702631A |
0.416 |
|
| 2008 |
Cullen MD, Cheung YF, Houslay MD, Hartman TL, Watson KM, Buckheit RW, Pannecouque C, De Clercq E, Cushman M. Investigation of the alkenyldiarylmethane non-nucleoside reverse transcriptase inhibitors as potential cAMP phosphodiesterase-4B2 inhibitors. Bioorganic & Medicinal Chemistry Letters. 18: 1530-3. PMID 18222088 DOI: 10.1016/J.Bmcl.2007.12.015 |
0.35 |
|
| 2008 |
Cullen MD, Sarkar T, Hamel E, Hartman TL, Watson KM, Buckheit RW, Pannecouque C, De Clercq E, Cushman M. Inhibition of tubulin polymerization by select alkenyldiarylmethanes. Bioorganic & Medicinal Chemistry Letters. 18: 469-73. PMID 18083556 DOI: 10.1016/J.Bmcl.2007.11.114 |
0.404 |
|
| 2007 |
Edsall AB, Agoston GE, Treston AM, Plum SM, McClanahan RH, Lu TS, Song W, Cushman M. Synthesis and in vivo antitumor evaluation of 2-methoxyestradiol 3-phosphate, 17-phosphate, and 3,17-diphosphate. Journal of Medicinal Chemistry. 50: 6700-5. PMID 18052315 DOI: 10.1021/Jm070639E |
0.764 |
|
| 2007 |
Antony S, Agama KK, Miao ZH, Takagi K, Wright MH, Robles AI, Varticovski L, Nagarajan M, Morrell A, Cushman M, Pommier Y. Novel indenoisoquinolines NSC 725776 and NSC 724998 produce persistent topoisomerase I cleavage complexes and overcome multidrug resistance. Cancer Research. 67: 10397-405. PMID 17974983 DOI: 10.1158/0008-5472.Can-07-0938 |
0.381 |
|
| 2007 |
Cullen MD, Deng BL, Hartman TL, Watson KM, Buckheit RW, Pannecouque C, Clercq ED, Cushman M. Synthesis and biological evaluation of alkenyldiarylmethane HIV-1 non-nucleoside reverse transcriptase inhibitors that possess increased hydrolytic stability. Journal of Medicinal Chemistry. 50: 4854-67. PMID 17803290 DOI: 10.1021/Jm070382K |
0.419 |
|
| 2007 |
Zhang Y, Jin G, Illarionov B, Bacher A, Fischer M, Cushman M. A new series of 3-alkyl phosphate derivatives of 4,5,6,7-tetrahydro-1-D- ribityl-1H-pyrazolo[3,4-d]pyrimidinedione as inhibitors of lumazine synthase: Design, synthesis, and evaluation Journal of Organic Chemistry. 72: 7176-7184. PMID 17705537 DOI: 10.1021/Jo070982R |
0.437 |
|
| 2007 |
Talukdar A, Illarionov B, Bacher A, Fischer M, Cushman M. Synthesis and enzyme inhibitory activity of the S-nucleoside analogue of the ribitylaminopyrimidine substrate of lumazine synthase and product of riboflavin synthase Journal of Organic Chemistry. 72: 7167-7175. PMID 17696548 DOI: 10.1021/Jo0709495 |
0.417 |
|
| 2007 |
Morrell A, Placzek M, Parmley S, Antony S, Dexheimer TS, Pommier Y, Cushman M. Nitrated indenoisoquinolines as topoisomerase I inhibitors: a systematic study and optimization. Journal of Medicinal Chemistry. 50: 4419-30. PMID 17696418 DOI: 10.1021/Jm070361Q |
0.41 |
|
| 2007 |
Morrell A, Placzek M, Parmley S, Grella B, Antony S, Pommier Y, Cushman M. Optimization of the indenone ring of indenoisoquinoline topoisomerase I inhibitors. Journal of Medicinal Chemistry. 50: 4388-404. PMID 17676830 DOI: 10.1021/Jm070307+ |
0.401 |
|
| 2007 |
Sakamoto T, Cullen MD, Hartman TL, Watson KM, Buckheit RW, Pannecouque C, De Clercq E, Cushman M. Synthesis and anti-HIV activity of new metabolically stable alkenyldiarylmethane non-nucleoside reverse transcriptase inhibitors incorporating N-methoxy imidoyl halide and 1,2,4-oxadiazole systems. Journal of Medicinal Chemistry. 50: 3314-21. PMID 17579385 DOI: 10.1021/Jm070236E |
0.363 |
|
| 2007 |
Maiti A, Cuendet M, Croy VL, Endringer DC, Pezzuto JM, Cushman M. Synthesis and biological evaluation of (+/-)-abyssinone II and its analogues as aromatase inhibitors for chemoprevention of breast cancer. Journal of Medicinal Chemistry. 50: 2799-806. PMID 17511439 DOI: 10.1021/Jm070109I |
0.399 |
|
| 2007 |
Morgunova E, Saller S, Haase I, Cushman M, Bacher A, Fischer M, Ladenstein R. Lumazine synthase from Candida albicans as an anti-fungal target enzyme: Structural and biochemical basis for drug design Journal of Biological Chemistry. 282: 17231-17241. PMID 17446177 DOI: 10.1074/Jbc.M701724200 |
0.352 |
|
| 2007 |
Morrell A, Placzek MS, Steffen JD, Antony S, Agama K, Pommier Y, Cushman M. Investigation of the lactam side chain length necessary for optimal indenoisoquinoline topoisomerase I inhibition and cytotoxicity in human cancer cell cultures. Journal of Medicinal Chemistry. 50: 2040-8. PMID 17402722 DOI: 10.1021/Jm0613119 |
0.385 |
|
| 2007 |
Kaiser J, Illarionov B, Rohdich F, Eisenreich W, Saller S, den Brulle JV, Cushman M, Bacher A, Fischer M. A high-throughput screening platform for inhibitors of the riboflavin biosynthesis pathway Analytical Biochemistry. 365: 52-61. PMID 17400171 DOI: 10.1016/J.Ab.2007.02.033 |
0.348 |
|
| 2007 |
Kim HY, Kuhn RJ, Patkar C, Warrier R, Cushman M. Synthesis of dioxane-based antiviral agents and evaluation of their biological activities as inhibitors of Sindbis virus replication. Bioorganic & Medicinal Chemistry. 15: 2667-79. PMID 17287124 DOI: 10.1016/J.Bmc.2007.01.040 |
0.381 |
|
| 2007 |
Maiti A, Cuendet M, Kondratyuk T, Croy VL, Pezzuto JM, Cushman M. Synthesis and cancer chemopreventive activity of zapotin, a natural product from Casimiroa edulis. Journal of Medicinal Chemistry. 50: 350-5. PMID 17228877 DOI: 10.1021/Jm060915+ |
0.386 |
|
| 2006 |
Morrell A, Antony S, Kohlhagen G, Pommier Y, Cushman M. A systematic study of nitrated indenoisoquinolines reveals a potent topoisomerase I inhibitor. Journal of Medicinal Chemistry. 49: 7740-53. PMID 17181156 DOI: 10.1021/Jm060974N |
0.438 |
|
| 2006 |
Nagarajan M, Morrell A, Ioanoviciu A, Antony S, Kohlhagen G, Agama K, Hollingshead M, Pommier Y, Cushman M. Synthesis and evaluation of indenoisoquinoline topoisomerase I inhibitors substituted with nitrogen heterocycles. Journal of Medicinal Chemistry. 49: 6283-9. PMID 17034134 DOI: 10.1021/Jm060564Z |
0.824 |
|
| 2006 |
Morgunova E, Illarionov B, Sambaiah T, Haase I, Bacher A, Cushman M, Fischer M, Ladenstein R. Structural and thermodynamic insights into the binding mode of five novel inhibitors of lumazine synthase from Mycobacterium tuberculosis Febs Journal. 273: 4790-4804. PMID 16984393 DOI: 10.1111/J.1742-4658.2006.05481.X |
0.382 |
|
| 2006 |
Deng BL, Hartman TL, Buckheit RW, Pannecouque C, De Clercq E, Cushman M. Replacement of the metabolically labile methyl esters in the alkenyldiarylmethane series of non-nucleoside reverse transcriptase inhibitors with isoxazolone, isoxazole, oxazolone, or cyano substituents. Journal of Medicinal Chemistry. 49: 5316-23. PMID 16913721 DOI: 10.1021/Jm060449O |
0.415 |
|
| 2006 |
Nagarajan M, Morrell A, Antony S, Kohlhagen G, Agama K, Pommier Y, Ragazzon PA, Garbett NC, Chaires JB, Hollingshead M, Cushman M. Synthesis and biological evaluation of bisindenoisoquinolines as topoisomerase I inhibitors Journal of Medicinal Chemistry. 49: 5129-5140. PMID 16913702 DOI: 10.1021/Jm060046O |
0.491 |
|
| 2006 |
Hamel E, Day BW, Miller JH, Jung MK, Northcote PT, Ghosh AK, Curran DP, Cushman M, Nicolaou KC, Paterson I, Sorensen EJ. Synergistic effects of peloruside A and laulimalide with taxoid site drugs, but not with each other, on tubulin assembly. Molecular Pharmacology. 70: 1555-64. PMID 16887932 DOI: 10.1124/Mol.106.027847 |
0.341 |
|
| 2006 |
Antony S, Agama KK, Miao ZH, Hollingshead M, Holbeck SL, Wright MH, Varticovski L, Nagarajan M, Morrell A, Cushman M, Pommier Y. Bisindenoisoquinoline bis-1,3-{(5,6-dihydro-5,11-diketo-11H-indeno[1,2-c]isoquinoline)-6-propylamino}propane bis(trifluoroacetate) (NSC 727357), a DNA intercalator and topoisomerase inhibitor with antitumor activity. Molecular Pharmacology. 70: 1109-20. PMID 16798938 DOI: 10.1124/Mol.106.024372 |
0.428 |
|
| 2006 |
Anadu NO, Davisson VJ, Cushman M. Synthesis and anticancer activity of brefeldin A ester derivatives. Journal of Medicinal Chemistry. 49: 3897-905. PMID 16789745 DOI: 10.1021/Jm0602817 |
0.442 |
|
| 2006 |
Morrell A, Jayaraman M, Nagarajan M, Fox BM, Meckley MR, Ioanoviciu A, Pommier Y, Antony S, Hollingshead M, Cushman M. Evaluation of indenoisoquinoline topoisomerase I inhibitors using a hollow fiber assay. Bioorganic & Medicinal Chemistry Letters. 16: 4395-9. PMID 16750365 DOI: 10.1016/J.Bmcl.2006.05.048 |
0.78 |
|
| 2006 |
Kim HY, Talukdar aA, Cushman M. Regioselective Synthesis of N-β-Hydroxyethylaziridines by the Ring Opening Reaction of Epoxides with Aziridine Generated In Situ Organic Letters. 8: 1085-1087. PMID 16524274 DOI: 10.1021/Ol0529703 |
0.323 |
|
| 2006 |
Marchand C, Antony S, Kohn KW, Cushman M, Ioanoviciu A, Staker BL, Burgin AB, Stewart L, Pommier Y. A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex. Molecular Cancer Therapeutics. 5: 287-95. PMID 16505102 DOI: 10.1158/1535-7163.Mct-05-0456 |
0.777 |
|
| 2006 |
Xiao X, Antony S, Pommier Y, Cushman M. Total synthesis and biological evaluation of 22-hydroxyacuminatine Journal of Medicinal Chemistry. 49: 1408-1412. PMID 16480276 DOI: 10.1021/Jm051116E |
0.375 |
|
| 2006 |
Morrell A, Antony S, Kohlhagen G, Pommier Y, Cushman M. Synthesis of benz[d]indeno[1,2-b]pyran-5,11-diones: Versatile intermediates for the design and synthesis of topoisomerase I inhibitors Bioorganic and Medicinal Chemistry Letters. 16: 1846-1849. PMID 16442283 DOI: 10.1016/J.Bmcl.2006.01.008 |
0.392 |
|
| 2006 |
Deng BL, Cullen MD, Zhou Z, Hartman TL, Buckheit RW, Pannecouque C, De Clercq E, Fanwick PE, Cushman M. Synthesis and anti-HIV activity of new alkenyldiarylmethane (ADAM) non-nucleoside reverse transcriptase inhibitors (NNRTIs) incorporating benzoxazolone and benzisoxazole rings. Bioorganic & Medicinal Chemistry. 14: 2366-74. PMID 16321539 DOI: 10.1016/J.Bmc.2005.11.014 |
0.406 |
|
| 2006 |
Ramsperger A, Augustin M, Schott AK, Gerhardt S, Krojer T, Eisenreich W, Illarionov B, Cushman M, Bacher A, Huber R, Fischer M. Crystal structure of an archaeal pentameric riboflavin synthase in complex with a substrate analog inhibitor: Stereochemical implications Journal of Biological Chemistry. 281: 1224-1232. PMID 16272154 DOI: 10.1074/Jbc.M509440200 |
0.341 |
|
| 2005 |
Cushman M, Jin G, Illarionov B, Fischer M, Ladenstein R, Bacher A. Design, Synthesis, and Biochemical Evaluation of 1,5,6,7-Tetrahydro-6,7-dioxo-9-d-Ribitylaminolumazines Bearing Alkyl Phosphate Substituents as Inhibitors of Lumazine Synthase and Riboflavin Synthase. Journal of Organic Chemistry. 70: 8162-8170. PMID 16277343 DOI: 10.1021/Jo051332V |
0.436 |
|
| 2005 |
Xiao X, Cushman M. Effect of E-Ring Modifications in Camptothecin on Topoisomerase I Inhibition: A Quantum Mechanics Treatment Journal of Organic Chemistry. 70: 9584-9587. PMID 16268636 DOI: 10.1021/Jo0513360 |
0.345 |
|
| 2005 |
Deng BL, Hartman TL, Buckheit RW, Pannecouque C, De Clercq E, Fanwick PE, Cushman M. Synthesis, anti-HIV activity, and metabolic stability of new alkenyldiarylmethane HIV-1 non-nucleoside reverse transcriptase inhibitors. Journal of Medicinal Chemistry. 48: 6140-55. PMID 16162014 DOI: 10.1021/Jm050452S |
0.34 |
|
| 2005 |
Xiao X, Cushman M. A Facile method to transform trans-4-carboxy-3,4-dihydro-3-phenyl- 1(2H)-isoquinolones to indeno[1,2-c]isoquinolines. Journal of Organic Chemistry. 70: 6496-6498. PMID 16050715 DOI: 10.1021/Jo050831T |
0.316 |
|
| 2005 |
Ioanoviciu A, Antony S, Pommier Y, Staker BL, Stewart L, Cushman M. Synthesis and mechanism of action studies of a series of norindenoisoquinoline topoisomerase I poisons reveal an inhibitor with a flipped orientation in the ternary DNA-enzyme-inhibitor complex as determined by X-ray crystallographic analysis. Journal of Medicinal Chemistry. 48: 4803-14. PMID 16033260 DOI: 10.1021/Jm050076B |
0.809 |
|
| 2005 |
Xiao X, Cushman M. An Ab Initio Quantum Mechanics Calculation that Correlates with Ligand Orientation and DNA Cleavage Site Selectivity in Camptothecin-DNA-Topoisomerase I Ternary Cleavage Complexes Journal of the American Chemical Society. 127: 9960-9961. PMID 16011334 DOI: 10.1021/Ja042485N |
0.306 |
|
| 2005 |
Kim HY, Patkar C, Warrier R, Kuhn R, Cushman M. Design, synthesis, and evaluation of dioxane-based antiviral agents targeted against the Sindbis virus capsid protein. Bioorganic & Medicinal Chemistry Letters. 15: 3207-11. PMID 15927464 DOI: 10.1016/J.Bmcl.2005.05.013 |
0.34 |
|
| 2005 |
Xiao X, Miao ZH, Antony S, Pommier Y, Cushman M. Dihydroindenoisoquinolines function as prodrugs of indenoisoquinolines Bioorganic and Medicinal Chemistry Letters. 15: 2795-2798. PMID 15911256 DOI: 10.1016/J.Bmcl.2005.03.101 |
0.406 |
|
| 2005 |
Xiao X, Antony S, Pommier Y, Cushman M. On the binding of indeno[1,2-c]isoquinolines in the DNA-topoisomerase I cleavage complex Journal of Medicinal Chemistry. 48: 3231-3238. PMID 15857129 DOI: 10.1021/Jm050017Y |
0.322 |
|
| 2005 |
Staker BL, Feese MD, Cushman M, Pommier Y, Zembower D, Stewart L, Burgin AB. Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex. Journal of Medicinal Chemistry. 48: 2336-45. PMID 15801827 DOI: 10.1021/Jm049146P |
0.335 |
|
| 2005 |
Morgunova E, Meining W, Illarionov B, Haase I, Jin G, Bacher A, Cushman M, Fischer M, Ladenstein R. Crystal Structure of Lumazine Synthase from Mycobacterium Tuberculosis as a Target for Rational Drug Design: Binding Mode of a New Class of Purinetrione Inhibitors(,) Biochemistry. 44: 2746-2758. PMID 15723519 DOI: 10.1021/Bi047848A |
0.366 |
|
| 2005 |
Chen J, Illarionov B, Bacher A, Fischer M, Haase I, Georg G, Ye QZ, Ma Z, Cushman M. A high-throughput screen utilizing the fluorescence of riboflavin for identification of lumazine synthase inhibitors Analytical Biochemistry. 338: 124-130. PMID 15707942 DOI: 10.1016/J.Ab.2004.11.033 |
0.487 |
|
| 2005 |
Antony S, Kohlhagen G, Agama K, Jayaraman M, Cao S, Durrani FA, Rustum YM, Cushman M, Pommier Y. Cellular topoisomerase I inhibition and antiproliferative activity by MJ-III-65 (NSC 706744), an indenoisoquinoline topoisomerase I poison. Molecular Pharmacology. 67: 523-30. PMID 15531731 DOI: 10.1124/Mol.104.003889 |
0.363 |
|
| 2004 |
Nagarajan M, Morrell A, Fort BC, Meckley MR, Antony S, Kohlhagen G, Pommier Y, Cushman M. Synthesis and anticancer activity of simplified indenoisoquinoline topoisomerase I inhibitors lacking substituents on the aromatic rings Journal of Medicinal Chemistry. 47: 5651-5661. PMID 15509164 DOI: 10.1021/Jm040025Z |
0.481 |
|
| 2004 |
Xiao X, Antony S, Kohlhagen G, Pommier Y, Cushman M. Novel autoxidative cleavage reaction of 9-fluoredenes discovered during synthesis of a potential DNA-threading indenoisoquinoline Journal of Organic Chemistry. 69: 7495-7501. PMID 15497974 DOI: 10.1021/Jo048808F |
0.435 |
|
| 2004 |
Chen J, Sambaiah T, Illarionov B, Fischer M, Bacher aA, Cushman M. Design, synthesis, and evaluation of acyclic C-nucleoside and N-methylated derivatives of the ribitylaminopyrimidine substrate of lumazine synthase as potential enzyme inhibitors and mechanistic probes. Journal of Organic Chemistry. 69: 6996-7003. PMID 15471444 DOI: 10.1021/Jo048975F |
0.534 |
|
| 2004 |
Edsall AB, Mohanakrishnan AK, Yang D, Fanwick PE, Hamel E, Hanson AD, Agoston GE, Cushman M. Effects of altering the electronics of 2-methoxyestradiol on cell proliferation, on cytotoxicity in human cancer cell cultures, and on tubulin polymerization. Journal of Medicinal Chemistry. 47: 5126-39. PMID 15456256 DOI: 10.1021/Jm049647A |
0.778 |
|
| 2004 |
Xiao X, Antony S, Kohlhagen G, Pommier Y, Cushman M. Design, synthesis, and biological evaluation of cytotoxic 11-aminoalkenylindenoisoquinoline and 11-diaminoalkenylindenoisoquinoline topoisomerase I inhibitors Bioorganic and Medicinal Chemistry. 12: 5147-5160. PMID 15351398 DOI: 10.1016/J.Bmc.2004.07.027 |
0.451 |
|
| 2004 |
Morrell A, Antony S, Kohlhagen G, Pommier Y, Cushman M. Synthesis of nitrated indenoisoquinolines as topoisomerase I inhibitors Bioorganic and Medicinal Chemistry Letters. 14: 3659-3663. PMID 15203138 DOI: 10.1016/J.Bmcl.2004.05.022 |
0.44 |
|
| 2004 |
Silvestri MA, Nagarajan M, Clercq ED, Pannecouque C, Cushman M. Design, synthesis, anti-HIV activities, and metabolic stabilities of alkenyldiarylmethane (ADAM) non-nucleoside reverse transcriptase inhibitors. Journal of Medicinal Chemistry. 47: 3149-3162. PMID 15163195 DOI: 10.1021/Jm049916X |
0.375 |
|
| 2004 |
Cushman M, Sambaiah T, Jin G, Illarionov B, Fischer M, Bacher A. Design, Synthesis, and Evaluation of 9-d-Ribitylamino-1,3,7,9-tetrahydro-2,6,8-purinetriones Bearing Alkyl Phosphate and α,α-Difluorophosphonate Substituents as Inhibitors of Riboflavin Synthase and Lumazine Synthase Journal of Organic Chemistry. 69: 601-612. PMID 14750781 DOI: 10.1021/Jo030278K |
0.411 |
|
| 2004 |
Xiao X, Fanwick PE, Cushman M. Synthesis, Crystal Structure, and Conversion of the Polycyclic Tris‐Anhydrotetramer of O‐Aminobenzaldehyde to Cu(TAAB)2+ Synthetic Communications. 34: 3901-3907. DOI: 10.1081/Scc-200034780 |
0.32 |
|
| 2003 |
Nagarajan M, Xiao X, Antony S, Kohlhagen G, Pommier Y, Cushman M. Design, Synthesis, and Biological Evaluation of Indenoisoquinoline Topoisomerase I Inhibitors Featuring Polyamine Side Chains on the Lactam Nitrogen Journal of Medicinal Chemistry. 46: 5712-5724. PMID 14667224 DOI: 10.1021/Jm030313F |
0.479 |
|
| 2003 |
Fox BM, Xiao X, Antony S, Kohlhagen G, Pommier Y, Staker BL, Stewart L, Cushman M. Design, synthesis, and biological evaluation of cytotoxic 11-alkenylindenoisoquinoline topoisomerase I inhibitors and indenoisoquinoline-camptothecin hybrids. Journal of Medicinal Chemistry. 46: 3275-82. PMID 12852757 DOI: 10.1021/Jm0300476 |
0.461 |
|
| 2003 |
Mu F, Hamel E, Lee DJ, Pryor DE, Cushman M. Synthesis, anticancer activity, and inhibition of tubulin polymerization by conformationally restricted analogues of lavendustin A. Journal of Medicinal Chemistry. 46: 1670-82. PMID 12699385 DOI: 10.1021/Jm020292+ |
0.455 |
|
| 2003 |
Fischer M, Haase I, Kis K, Meining W, Ladenstein R, Cushman M, Schramek N, Huber R, Bacher A. Enzyme catalysis via control of activation entropy: site-directed mutagenesis of 6,7-dimethyl-8-ribityllumazine synthase. Journal of Molecular Biology. 326: 783-793. PMID 12581640 DOI: 10.1016/S0022-2836(02)01473-0 |
0.321 |
|
| 2003 |
Udata C, Patel J, Pal D, Hejchman E, Cushman M, Mitra AK. Enhanced transport of a novel anti-HIV agent--cosalane and its congeners across human intestinal epithelial (Caco-2) cell monolayers. International Journal of Pharmaceutics. 250: 157-68. PMID 12480282 DOI: 10.1016/S0378-5173(02)00523-9 |
0.371 |
|
| 2003 |
Cushman M, Yang D, Mihalic JT, Chen J, Gerhardt S, Huber R, Fischer M, Kis K, Bacher A. Incorporation of an amide into 5-phosphonoalkyl-6-D-ribitylaminopyrimidinedione lumazine synthase inhibitors results in an unexpected reversal of selectivity for riboflavin synthase vs lumazine synthase. The Journal of Organic Chemistry. 67: 6871-7. PMID 12353976 DOI: 10.1021/Jo020144R |
0.565 |
|
| 2002 |
Mu F, Lee DJ, Pryor DE, Hamel E, Cushman M. Synthesis and investigation of conformationally restricted analogues of lavendustin A as cytotoxic inhibitors of tubulin polymerization. Journal of Medicinal Chemistry. 45: 4774-85. PMID 12361405 DOI: 10.1021/Jm0202270 |
0.457 |
|
| 2002 |
Cushman M, Mohanakrishnan AK, Hollingshead M, Hamel E. The effect of exchanging various substituents at the 2-position of 2-methoxyestradiol on cytotoxicity in human cancer cell cultures and inhibition of tubulin polymerization. Journal of Medicinal Chemistry. 45: 4748-4754. PMID 12361402 DOI: 10.1021/Jm020218R |
0.462 |
|
| 2002 |
Cushman M, Yang D, Gerhardt S, Huber R, Fischer M, Kis K, Bacher A. Design, synthesis, and evaluation of 6-carboxyalkyl and 6-phosphonoxyalkyl derivatives of 7-oxo-8-ribitylaminolumazines as inhibitors of riboflavin synthase and lumazine synthase. The Journal of Organic Chemistry. 67: 5807-16. PMID 12153285 DOI: 10.1021/Jo0201631 |
0.413 |
|
| 2002 |
Gerhardt S, Haase I, Steinbacher S, Kaiser JT, Cushman M, Bacher A, Huber R, Fischer M. The structural basis of riboflavin binding to Schizosaccharomyces pombe 6,7-dimethyl-8-ribityllumazine synthase. Journal of Molecular Biology. 318: 1317-29. PMID 12083520 DOI: 10.1016/S0022-2836(02)00116-X |
0.32 |
|
| 2002 |
Xu G, Kannan A, Hartman TL, Wargo H, Watson K, Turpin JA, Buckheit RW, Johnson AA, Pommier Y, Cushman M. Synthesis of substituted diarylmethylenepiperidines (DAMPs), a novel class of anti-HIV agents. Bioorganic & Medicinal Chemistry. 10: 2807-16. PMID 12057671 DOI: 10.1016/S0968-0896(02)00095-0 |
0.347 |
|
| 2002 |
Hughes RA, Harris T, Altmann E, McAllister D, Vlahos R, Robertson A, Cushman M, Wang Z, Stewart AG. 2-Methoxyestradiol and analogs as novel antiproliferative agents: analysis of three-dimensional quantitative structure-activity relationships for DNA synthesis inhibition and estrogen receptor binding. Molecular Pharmacology. 61: 1053-69. PMID 11961123 DOI: 10.1124/Mol.61.5.1053 |
0.424 |
|
| 2002 |
Kuchimanchi KR, Gandhi MD, Sheta RR, Johnston TP, Santhosh KC, Cushman M, Mitra AK. Intestinal absorption and biodistribution of cosalane and its amino acid conjugates: novel anti-HIV agents. International Journal of Pharmaceutics. 231: 197-211. PMID 11755272 DOI: 10.1016/S0378-5173(01)00884-5 |
0.331 |
|
| 2002 |
Jayaraman M, Fox BM, Hollingshead M, Kohlhagen G, Pommier Y, Cushman M. Synthesis of new dihydroindeno[1,2-c]isoquinoline and indenoisoquinolinium chloride topoisomerase I inhibitors having high in vivo anticancer activity in the hollow fiber animal model. Journal of Medicinal Chemistry. 45: 242-249. PMID 11754595 DOI: 10.1021/Jm000498F |
0.429 |
|
| 2002 |
Xu G, Hartman TL, Wargo H, Turpin JA, Buckheit RW, Cushman M. Synthesis of alkenyldiarylmethane (ADAM) non-nucleoside HIV-1 reverse transcriptase inhibitors with non-identical aromatic rings. Bioorganic & Medicinal Chemistry. 10: 283-90. PMID 11741777 DOI: 10.1016/S0968-0896(01)00282-6 |
0.385 |
|
| 2001 |
Cushman M, Yang D, Kis K, Bacher A. Design, synthesis, and evaluation of 9-D-ribityl-1,3,7-trihydro-2,6,8-purinetrione, a potent inhibitor of riboflavin synthase and lumazine synthase. Journal of Organic Chemistry. 66: 8320-8327. PMID 11735509 DOI: 10.1021/Jo010706R |
0.365 |
|
| 2001 |
Xu G, Micklatcher M, Silvestri MA, Hartman TL, Burrier J, Osterling MC, Wargo H, Turpin JA, Buckheit RW, Cushman M. The biological effects of structural variation at the meta position of the aromatic rings and at the end of the alkenyl chain in the alkenyldiarylmethane series of non-nucleoside reverse transcriptase inhibitors Journal of Medicinal Chemistry. 44: 4092-4113. PMID 11708913 DOI: 10.1021/Jm010212M |
0.795 |
|
| 2001 |
Fox BM, Vroman JA, Fanwick PE, Cushman M. Preparation and evaluation of sulfide derivatives of the antibiotic brefeldin a as potential prodrug candidates with enhanced aqueous solubilities. Journal of Medicinal Chemistry. 44: 3915-3924. PMID 11689077 DOI: 10.1021/Jm010054Z |
0.369 |
|
| 2001 |
Casimiro-Garcia A, Clercq ED, Pannecouque C, Witvrouw M, Loftus TL, Turpin JA, Buckheit RW, Fanwick PE, Cushman M. Synthesis and anti-HIV activity of cosalane analogues incorporating two dichlorodisalicylmethane pharmacophore fragments. Bioorganic & Medicinal Chemistry. 9: 2827-2841. PMID 11597463 DOI: 10.1016/S0968-0896(01)00152-3 |
0.399 |
|
| 2001 |
Xu G, Loftus TL, Wargo H, Turpin JA, Buckheit RW, Cushman M. Solid-Phase Synthesis of the Alkenyldiarylmethane (ADAM) Series of Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors Journal of Organic Chemistry. 66: 5958-5964. PMID 11529718 DOI: 10.1021/Jo0100291 |
0.417 |
|
| 2001 |
Mu F, Coffing SL, Riese DJ, Geahlen RL, Verdier-Pinard P, Hamel TE, Johnson J, Cushman M. Design, synthesis, and biological evaluation of a series of lavendustin A analogues that inhibit EGFR and Syk tyrosine kinases, as well as tubulin polymerization. Journal of Medicinal Chemistry. 44: 441-52. PMID 11462983 DOI: 10.1021/Jm000387G |
0.411 |
|
| 2001 |
Santhosh KC, Paul GC, Clercq ED, Pannecouque C, Witvrouw M, Loftus TL, Turpin JA, Buckheit RW, Cushman M. Correlation of Anti-HIV Activity with Anion Spacing in a Series of Cosalane Analogues with Extended Polycarboxylate Pharmacophores Journal of Medicinal Chemistry. 44: 703-714. PMID 11262081 DOI: 10.1021/Jm000290U |
0.336 |
|
| 2001 |
Howard OM, Dong HF, Oppenheim JJ, Insaf S, Santhosh KC, Paul G, Cushman M. Inhibition of RANTES/CCR1-mediated chemotaxis by cosalane and related compounds. Bioorganic & Medicinal Chemistry Letters. 11: 59-62. PMID 11140734 DOI: 10.1016/S0960-894X(00)00601-6 |
0.398 |
|
| 2001 |
Kannan A, De Clercq E, Pannecouque C, Witvrouw M, Hartman TL, Turpin JA, Buckheit RW, Cushman M. Synthesis and anti-HIV activity of a bile acid analog of cosalane Tetrahedron. 57: 9385-9391. DOI: 10.1016/S0040-4020(01)00955-3 |
0.347 |
|
| 2000 |
Santhosh KC, Clercq ED, Pannecouque C, Witvrouw M, Loftus TL, Turpin JA, Buckheit RW, Cushman M. Anti-HIV activity of a series of cosalane amino acid conjugates. Bioorganic & Medicinal Chemistry Letters. 10: 2505-2508. PMID 11086716 DOI: 10.1016/S0960-894X(00)00515-1 |
0.316 |
|
| 2000 |
Cushman M, Jayaraman M, Vroman JA, Fukunaga AK, Fox BM, Kohlhagen G, Strumberg D, Pommier Y. Synthesis of new indeno[1,2-c]isoquinolines: cytotoxic non-camptothecin topoisomerase I inhibitors. Journal of Medicinal Chemistry. 43: 3688-3698. PMID 11020283 DOI: 10.1021/Jm000029D |
0.48 |
|
| 2000 |
Paul GC, Clercq ED, Pannecouque C, Witvrouw M, Loftus TL, Turpin JA, Buckheit RW, Cushman M. Identification of optimal anion spacing for anti-HIV activity in a series of cosalane tetracarboxylates Bioorganic & Medicinal Chemistry Letters. 10: 2149-2152. PMID 10999491 DOI: 10.1016/S0960-894X(00)00417-0 |
0.307 |
|
| 2000 |
Casimiro-Garcia A, Clercq ED, Pannecouque C, Witvrouw M, Stup TL, Turpin JA, Buckheit RW, Cushman M. Synthesis and anti-HIV activity of cosalane analogues incorporating nitrogen in the linker chain. Bioorganic & Medicinal Chemistry. 8: 191-200. PMID 10968278 DOI: 10.1016/S0968-0896(99)00269-2 |
0.361 |
|
| 2000 |
Wang Z, Yang D, Mohanakrishnan AK, Fanwick PE, Nampoothiri P, Hamel E, Cushman M. Synthesis of B-ring homologated estradiol analogues that modulate tubulin polymerization and microtubule stability. Journal of Medicinal Chemistry. 43: 2419-2429. PMID 10882369 DOI: 10.1021/Jm0001119 |
0.389 |
|
| 2000 |
Verdier-Pinard P, Wang Z, Mohanakrishnan AK, Cushman M, Hamel E. A Steroid Derivative with Paclitaxel-Like Effects on Tubulin Polymerization Molecular Pharmacology. 57: 568-575. PMID 10692498 DOI: 10.1124/Mol.57.3.568 |
0.436 |
|
| 1999 |
Cushman M, Mavandadi F, Yang D, Kugelbrey K, Kis K, Bacher A. Synthesis and Biochemical Evaluation of Bis(6,7-dimethyl-8-d-ribityllumazines) as Potential Bisubstrate Analogue Inhibitors of Riboflavin Synthase Journal of Organic Chemistry. 64: 4635-4642. PMID 11674533 DOI: 10.1021/Jo9821731 |
0.361 |
|
| 1999 |
Casimiro-Garcia A, Micklatcher M, Turpin JA, Stup TL, Watson K, Buckheit RW, Cushman M. Novel modifications in the alkenyldiarylmethane (ADAM) series of non-nucleoside reverse transcriptase inhibitors. Journal of Medicinal Chemistry. 42: 4861-4874. PMID 10579849 DOI: 10.1021/Jm990343B |
0.789 |
|
| 1999 |
Cushman M, Mihalic JT, Kis K, Bacher A. Design and synthesis of 6-(6-D-ribitylamino-2,4-dihydroxypyrimidin-5-yl)-1-hexylphosphonic acid, a potent inhibitor of lumazine synthase Bioorganic & Medicinal Chemistry Letters. 9: 39-42. PMID 9990453 DOI: 10.1016/S0960-894X(98)00687-8 |
0.415 |
|
| 1999 |
Strumberg D, Pommier Y, Paull K, Jayaraman M, Nagafuji P, Cushman M. Synthesis of Cytotoxic Indenoisoquinoline Topoisomerase I Poisons Journal of Medicinal Chemistry. 42: 446-457. PMID 9986716 DOI: 10.1021/Jm9803323 |
0.375 |
|
| 1999 |
Micklatcher ML, Cushman M. An Improved Method for the Synthesis of 3-Fluorosalicylic Acid with Application to the Synthesis of 3-(Trifluoromethyl)salicylic Acid Synthesis. 1999: 1878-1880. DOI: 10.1055/S-1999-3607 |
0.759 |
|
| 1999 |
Ruell JA, Clercq ED, Pannecouque C, Witvrouw M, Stup TL, Turpin JA, Buckheit RW, Cushman M. Synthesis and Anti-HIV Activity of Cosalane Analogues with Substituted Benzoic Acid Rings Attached to the Pharmacophore through Methylene and Amide Linkers Journal of Organic Chemistry. 64: 5858-5866. DOI: 10.1021/Jo990177F |
0.427 |
|
| 1999 |
Cushman M, Mihalic JT, Kis K, Bacher A. Design, Synthesis, and Biological Evaluation of Homologous Phosphonic Acids and Sulfonic Acids as Inhibitors of Lumazine Synthase Journal of Organic Chemistry. 64: 3838-3845. DOI: 10.1021/Jo9821729 |
0.414 |
|
| 1998 |
Cushman M, Casimiro-Garcia A, Williamson K, Rice WG. Synthesis of a non-nucleoside reverse transcriptase inhibitor in the alkenyldiarylmethane (ADAM) series with optimized potency and therapeutic index Bioorganic & Medicinal Chemistry Letters. 8: 195-198. PMID 9871653 DOI: 10.1016/S0960-894X(97)10214-1 |
0.417 |
|
| 1998 |
Cushman M, Insaf S, Ruell JA, Schaeffer CA, Rice WG. Synthesis of a cosalane analog with an extended polyanionic pharmacophore conferring enhanced potency as an anti-HIV agent. Bioorganic & Medicinal Chemistry Letters. 8: 833-836. PMID 9871550 DOI: 10.1016/S0960-894X(98)00121-8 |
0.389 |
|
| 1998 |
Argade AB, Devraj R, Vroman JA, Haugwitz RD, Hollingshead M, Cushman M. Design and synthesis of brefeldin A sulfide derivatives as prodrug candidates with enhanced aqueous solubilities. Journal of Medicinal Chemistry. 41: 3337-46. PMID 9719586 DOI: 10.1021/Jm970746G |
0.424 |
|
| 1998 |
Kohlhagen G, Paull KD, Cushman M, Nagafuji P, Pommier Y. Protein-Linked DNA Strand Breaks Induced by NSC 314622, a Novel Noncamptothecin Topoisomerase I Poison Molecular Pharmacology. 54: 50-58. PMID 9658189 DOI: 10.1124/Mol.54.1.50 |
0.334 |
|
| 1998 |
Cushman M, Casimiro-Garcia A, Hejchman E, Ruell JA, Huang M, Schaeffer CA, Williamson K, Rice WG, Buckheit RW. New Alkenyldiarylmethanes with Enhanced Potencies as Anti-HIV Agents Which Act as Non-Nucleoside Reverse Transcriptase Inhibitors Journal of Medicinal Chemistry. 41: 2076-2089. PMID 9622549 DOI: 10.1021/Jm9800595 |
0.364 |
|
| 1998 |
Cushman M, Mavandadi F, Kugelbrey K, Bacher A. Synthesis of 2,6-dioxo-(1H,3H)-9-N-ribitylpurine and 2,6-dioxo-(1H,3H)-8-aza-9-N-ribitylpurine as inhibitors of lumazine synthase and riboflavin synthase. Bioorganic & Medicinal Chemistry. 6: 409-415. PMID 9597185 DOI: 10.1016/S0968-0896(98)00013-3 |
0.312 |
|
| 1998 |
Wang Z, Cushman M. An Optimized Synthesis of 2-Methoxyestradiol, A Naturally Occurring Human Metabolite with Anticancer Activity Synthetic Communications. 28: 4431-4437. DOI: 10.1080/00397919808004478 |
0.378 |
|
| 1997 |
Cushman M, He HM, Katzenellenbogen JA, Varma RK, Hamel E, Lin CM, Ram S, Sachdeva YP. Synthesis of analogs of 2-methoxyestradiol with enhanced inhibitory effects on tubulin polymerization and cancer cell growth. Journal of Medicinal Chemistry. 40: 2323-34. PMID 9240348 DOI: 10.1021/Jm9700833 |
0.468 |
|
| 1997 |
Cushman M, Mavandadi F, Kugelbrey K, Bacher A. Design and Synthesis of (Ribitylamino)uracils Bearing Fluorosulfonyl, Sulfonic Acid, and Carboxylic Acid Functionality as Inhibitors of Lumazine Synthase Journal of Organic Chemistry. 62: 8944-8947. DOI: 10.1021/Jo9712963 |
0.327 |
|
| 1996 |
Golebiewski WM, Keyes RF, Cushman M. Exploration of the effects of linker chain modifications on anti-HIV activities in a series of cosalane analogues. Bioorganic & Medicinal Chemistry. 4: 1637-1648. PMID 8931933 DOI: 10.1016/0968-0896(96)00159-9 |
0.315 |
|
| 1996 |
Devraj R, Barrett JF, Fernandez JA, Katzenellenbogen JA, Cushman M. Design, synthesis, and biological evaluation of ellipticine-estradiol conjugates. Journal of Medicinal Chemistry. 39: 3367-74. PMID 8765520 DOI: 10.1021/Jm9602930 |
0.379 |
|
| 1996 |
Devraj R, Cushman M. A Versatile Solid Phase Synthesis of Lavendustin A and Certain Biologically Active Analogs Journal of Organic Chemistry. 61: 9368-9373. DOI: 10.1021/Jo961719L |
0.384 |
|
| 1995 |
Cushman M, He HM, Katzenellenbogen JA, Lin CM, Hamel E. Synthesis, antitubulin and antimitotic activity, and cytotoxicity of analogs of 2-methoxyestradiol, an endogenous mammalian metabolite of estradiol that inhibits tubulin polymerization by binding to the colchicine binding site. Journal of Medicinal Chemistry. 38: 2041-9. PMID 7783135 DOI: 10.1021/Jm00012A003 |
0.445 |
|
| 1995 |
Hejchman E, Haugwitz RD, Cushman M. Synthesis and cytotoxicity of water-soluble ambrosin prodrug candidates. Journal of Medicinal Chemistry. 38: 3407-3410. PMID 7650694 DOI: 10.1021/Jm00017A025 |
0.364 |
|
| 1995 |
Cushman M, Wang P, Reymen D, Esté J, Witvrouw M, Neyts J, Clercq ED. Anti-HIV and anti-HCMV Activities of New Aurintricarboxylic Acid Analogues Antiviral Chemistry & Chemotherapy. 6: 179-186. DOI: 10.1177/095632029500600307 |
0.353 |
|
| 1995 |
Cushman M, Golebiewski M, Buckheit RW, Graham L, Rice WG. Synthesis And Biological Evaluation Of An Alkenyldiarylmethane (Adam) Which Acts As A Novel Non-Nucleoside Hiv-1 Reverse Transcriptase Inhibitor Bioorganic & Medicinal Chemistry Letters. 5: 2713-2716. DOI: 10.1016/0960-894X(95)00465-6 |
0.327 |
|
| 1994 |
Jurayj J, Haugwitz RD, Varma RK, Paull KD, Barrett JF, Cushman M. Design and synthesis of ellipticinium salts and 1,2-dihydroellipticines with high selectivities against human CNS cancers in Vitro Journal of Medicinal Chemistry. 37: 2190-2197. PMID 8035426 DOI: 10.1021/Jm00040A011 |
0.425 |
|
| 1994 |
Cushman M, Zhu H, Geahlen RL, Kraker AJ. Synthesis and biochemical evaluation of a series of aminoflavones as potential inhibitors of protein-tyrosine kinases p56lck, EGFr, and p60v-src. Journal of Medicinal Chemistry. 37: 3353-62. PMID 7932563 DOI: 10.1021/Jm00046A020 |
0.372 |
|
| 1994 |
Lee E, Cushman M. Synthesis of a phosphotyrosine-containing peptide fragment of the regulatory domain of pp60c-src Journal of Organic Chemistry. 59: 2086-2091. DOI: 10.1021/Jo00087A025 |
0.301 |
|
| 1994 |
He H, Geahlen RL, Cushman M. Synthesis of a series of brominated 1-phenyl-2-pyridylethenes as inhibitors of the protein-tyrosine kinase p56lck Bioorganic & Medicinal Chemistry Letters. 4: 1729-1732. DOI: 10.1016/S0960-894X(00)80370-4 |
0.367 |
|
| 1994 |
He H, Cushman M. A versatile synthesis of 2-methoxyestradiol, an endogenous metabolite of estradiol which inhibits tubulin polymerization by binding to the colchicine binding site Bioorganic & Medicinal Chemistry Letters. 4: 1725-1728. DOI: 10.1016/S0960-894X(00)80369-8 |
0.358 |
|
| 1994 |
Oh Y, Cushman M. Synthesis and anti-HIV activity of poly(cysteic acid) Bioorganic & Medicinal Chemistry Letters. 4: 2245-2248. DOI: 10.1016/S0960-894X(00)80079-7 |
0.356 |
|
| 1994 |
Lee E, Jurayj J, Cushman M. Synthesis of [L-3-Deoxymimosine4]-angiotensin I as an approach to the preparation of selective protein-tyrosine kinase (PTK) inhibitors Tetrahedron. 50: 9873-9882. DOI: 10.1016/S0040-4020(01)89603-4 |
0.311 |
|
| 1993 |
Thakkar K, Geahlen RL, Cushman M. Synthesis and protein-tyrosine kinase inhibitory activity of polyhydroxylated stilbene analogues of piceatannol. Journal of Medicinal Chemistry. 36: 2950-5. PMID 8411012 DOI: 10.1021/Jm00072A015 |
0.422 |
|
| 1993 |
Cushman M, He HM, Lin CM, Hamel E. Synthesis and evaluation of a series of benzylaniline hydrochlorides as potential cytotoxic and antimitotic agents acting by inhibition of tubulin polymerization Journal of Medicinal Chemistry. 36: 2817-2821. PMID 8410995 DOI: 10.1021/Jm00071A012 |
0.464 |
|
| 1993 |
Cushman M, Patel HH, Scheuring J, Bacher A. Fluorine-19 NMR studies of the mechanism of riboflavin synthase. Synthesis of 6-(trifluoromethyl)-8-(D-ribityl)lumazine and derivatives Journal of Organic Chemistry. 58: 4033-4042. DOI: 10.1021/Jo00067A041 |
0.356 |
|
| 1993 |
Golebiewski WM, Bader JP, Cushman M. Design and synthesis of cosalane, a novel anti-HIV agent Bioorganic & Medicinal Chemistry Letters. 3: 1739-1742. DOI: 10.1016/S0960-894X(00)80053-0 |
0.326 |
|
| 1992 |
Cushman M, Nagarathnam D, Geahlen RL. Synthesis and evaluation of hydroxylated flavones and related compounds as potential inhibitors of the protein-tyrosine kinase p56lck. Journal of Natural Products. 54: 1345-52. PMID 1800636 DOI: 10.1021/Np50077A018 |
0.426 |
|
| 1992 |
Cushman M, Nagarathnam D, Gopal D, He HM, Lin CM, Hamel E. Synthesis and evaluation of analogues of (Z)-1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethene as potential cytotoxic and antimitotic agents. Journal of Medicinal Chemistry. 35: 2293-2306. PMID 1613753 DOI: 10.1021/Jm00090A021 |
0.396 |
|
| 1992 |
Cushman M, Sherman P. Inhibition of HIV-1 integration protein by aurintricarboxylic acid monomers, monomer analogs, and polymer fractions. Biochemical and Biophysical Research Communications. 185: 85-90. PMID 1599491 DOI: 10.1016/S0006-291X(05)80958-1 |
0.345 |
|
| 1992 |
Cushman M, Patel HH, Scheuring J, Bacher A. Fluorine-19 NMR studies on the mechanism of riboflavin synthase. Synthesis of 6-(trifluoromethyl)-7-oxo-8-(D-ribityl)lumazine and 6-(trifluoromethyl)-7-methyl-8-(D-ribityl)lumazine Journal of Organic Chemistry. 57: 5630-5643. DOI: 10.1021/Jo00047A015 |
0.307 |
|
| 1992 |
Wang P, Kozlowski J, Cushman M. Isolation and structure elucidation of low molecular weight components of aurintricarboxylic acid (ATA) Journal of Organic Chemistry. 57: 3861-3866. DOI: 10.1021/Jo00040A027 |
0.318 |
|
| 1992 |
Chen J, Carlson DV, Weith HL, O'Brien JA, Goldman ME, Cushman M. Synthesis of an oligonucleotide-intercalator conjugate in which the linker chain is attached via the phenolic hydroxyl group of fagaronine Tetrahedron Letters. 33: 2275-2278. DOI: 10.1016/S0040-4039(00)74188-8 |
0.359 |
|
| 1992 |
Konieczny MT, Cushman M. A novel synthesis of compounds containing a fused pyrrole ring from cyclic ketones and N-BOC-L-phenylalaninal Tetrahedron Letters. 33: 6939-6940. DOI: 10.1016/S0040-4039(00)60900-0 |
0.364 |
|
| 1992 |
Jurayj J, Cushman M. Approaches to the synthesis of endothiopeptides: Synthesis of a thioamide-containing C-terminal bombesin nonapeptide Tetrahedron. 48: 8601-8614. DOI: 10.1016/S0040-4020(01)89436-9 |
0.371 |
|
| 1991 |
Cushman M, Chinnasamy P, Chakraborti AK, Jurayj J, Geahlen RL, Haugwitz RD. Synthesis of [beta-(4-pyridyl-1-oxide)-L-alanine4]-angiotensin I as a potential suicide substrate for protein-tyrosine kinases. International Journal of Peptide and Protein Research. 36: 538-43. PMID 2090646 DOI: 10.1111/J.1399-3011.1990.Tb00993.X |
0.564 |
|
| 1991 |
Cushman M, Nagarathnam D, Burg DL, Geahlen RL. Synthesis and protein-tyrosine kinase inhibitory activities of flavonoid analogues. Journal of Medicinal Chemistry. 34: 798-806. PMID 1995903 DOI: 10.1021/Jm00106A047 |
0.428 |
|
| 1991 |
Cushman M, Nagarathnam D, Gopal D, Chakraborti AK, Lin CM, Hamel E. Synthesis and evaluation of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerization. Journal of Medicinal Chemistry. 34: 2579-88. PMID 1875350 DOI: 10.1021/Jm00112A036 |
0.582 |
|
| 1991 |
Cushman M, Nagarathnam D. Cytotoxicities of some flavonoid analogues. Journal of Natural Products. 54: 1656-1660. PMID 1812215 DOI: 10.1021/Np50078A027 |
0.359 |
|
| 1991 |
Cushman M, Kanamathareddy S, Clercq ED, Schols D, Goldman ME, Bowen JA. Synthesis And Anti-Hiv Activities Of Low Molecular Weight Aurintricarboxylic Acid Fragments And Related Compounds Journal of Medicinal Chemistry. 34: 337-342. PMID 1704066 DOI: 10.1021/Jm00105A053 |
0.334 |
|
| 1991 |
Cushman M, Wang P, Chang SH, Wild C, Clercq ED, Schols D, Goldman ME, Bowen JA. Preparation and anti-HIV activities of aurintricarboxylic acid fractions and analogues: direct correlation of antiviral potency with molecular weight. Journal of Medicinal Chemistry. 34: 329-337. PMID 1704065 DOI: 10.1021/Jm00105A052 |
0.323 |
|
| 1991 |
Cushman M, Patrick DA, Bacher A, Scheuring J. Synthesis of epimeric 6,7-bis(trifluoromethyl)-8-ribityllumazine hydrates. Stereoselective interaction with the light riboflavin synthase of Bacillus subtilis Journal of Organic Chemistry. 56: 4603-4608. DOI: 10.1021/Jo00015A009 |
0.33 |
|
| 1991 |
Cushman M, Oh YI, Copeland TD, Oroszlan S, Snyder SW. Development of methodology for the synthesis of stereochemically pure Phe.psi.[CH2N]Pro linkages in HIV protease inhibitors Journal of Organic Chemistry. 56: 4161-4167. DOI: 10.1021/Jo00013A017 |
0.382 |
|
| 1991 |
Cushman M, Nagarathnam D, Gopal D, Geahlen RL. Synthesis and evaluation of new protein-tyrosine kinase inhibitors. Part 2. Phenylhydrazones. Bioorganic & Medicinal Chemistry Letters. 1: 215-218. DOI: 10.1016/S0960-894X(00)80255-3 |
0.358 |
|
| 1991 |
Cushman M, Nagarathnam D, Gopal D, Geahlen RL. Synthesis and evaluation of new protein-tyrosine kinase inhibitors. Part 1. pyridine-containing stilbenes and amides. Bioorganic & Medicinal Chemistry Letters. 1: 211-214. DOI: 10.1016/S0960-894X(00)80254-1 |
0.405 |
|
| 1991 |
Nagarathnam D, Cushman M. A practical synthesis of flavones from methyl salicylate Tetrahedron. 47: 5071-5076. DOI: 10.1016/S0040-4020(01)87119-2 |
0.303 |
|
| 1990 |
Pidgeon C, Weith HL, Darbishire-Weith D, Cushman M, Byrn SR, Chen JK, Stowell JG, Ray K, Carlson D. Synthesis and liposome encapsulation of antisense oligonucleotide-intercalator conjugates Annals of the New York Academy of Sciences. 616: 593-596. DOI: 10.1111/J.1749-6632.1990.Tb17902.X |
0.326 |
|
| 1990 |
Cushman M, Oh Y, Copeland TD, Snyder SW, Oroszlan S. An Approach to the Synthesis of HIV Protease Inhibitors Annals of the New York Academy of Sciences. 616: 503-507. DOI: 10.1111/J.1749-6632.1990.Tb17876.X |
0.334 |
|
| 1990 |
Cushman M, Jurayj J. A Synthesis of 2-Alkyl and 2-Benzyl Substituted Acrylonitriles from 2-Alkyl and 2-Benzylidene Cyanoacetate Esters under Mild Conditions Synthetic Communications. 20: 1463-1468. DOI: 10.1080/00397919008052862 |
0.332 |
|
| 1990 |
Cushman M, Chinnasamy P, Patrick DA, McKenzie AT, Toma PH. A novel ring expansion observed during the lithium aluminum hydride reduction of 13-nitrooxyberberine Journal of Organic Chemistry. 55: 5995-6000. DOI: 10.1021/Jo00311A018 |
0.327 |
|
| 1990 |
Cushman M, Jurayj J, Moyer JD. Synthesis, Biological Testing, And Stereochemical Assignment Of An End Group Modified Retro-Inverso Bombesin C-Terminal Nonapeptide Journal of Organic Chemistry. 55: 3186-3194. DOI: 10.1021/Jo00297A039 |
0.339 |
|
| 1990 |
Cushman M, Nagarathnam D. A method for the facile synthesis of ring-A hydroxylated flavones Tetrahedron Letters. 31: 6497-6500. DOI: 10.1016/S0040-4039(00)97100-4 |
0.347 |
|
| 1990 |
Cushman M, Kanamathareddy S. Synthesis of the covalent hydrate of the incorrectly assumed structure of aurintricarboxylic acid (ATA) Tetrahedron. 46: 1491-1498. DOI: 10.1016/S0040-4020(01)81957-8 |
0.348 |
|
| 1989 |
Iwasa K, Kamigauchi M, Takao N, Cushman M, Chen JK, Wong WC, McKenzie A. Synthesis and evaluation of hypothetical intermediates in the biosynthetic conversion of protoberberine to benzo[c]phenanthridine alkaloids. Evidence for oxidative carbon-nitrogen bond fission followed by intramolecular recyclization in cell cultures of Corydalis incisa Journal of the American Chemical Society. 111: 7925-7931. DOI: 10.1021/Ja00202A038 |
0.312 |
|
| 1988 |
Cushman M, Patel H, McKenzie A. Synthesis of trifluoromethylated pyrazine-containing nitrogen heterocycles from trifluoropyruvaldehyde and ortho-diamines: scope and regiochemistry Journal of Organic Chemistry. 53: 5088-5092. DOI: 10.1021/Jo00256A034 |
0.358 |
|
| 1986 |
Cushman M, Wong WC, Bacher A. Synthesis of 6,7-bis(trifluoromethyl)-8-substituted pteridine-2,4(1H,3H)-dione (lumazine) hydrates from 4,5-diaminouracil hydrochlorides and perfluorobutane-2,3-dione. Stabilization of the transmolecular covalent hydrates of 8-substituted pteridinediones by trifluoromethyl groups Journal of the Chemical Society-Perkin Transactions 1. 1051-1053. DOI: 10.1039/P19860001051 |
0.356 |
|
| 1986 |
Cushman M, Wong WC, Bacher A. Synthesis of bis(trifluoromethylated) pyrazine-containing nitrogen heterocycles from hexafluorobiacetyl and ortho-diamines. Stabilization of the covalent dihydrates of pteridines and pyrido[3,4-b]pyrazines by trifluoromethyl groups Journal of the Chemical Society, Perkin Transactions 1. 1043-1050. DOI: 10.1039/P19860001043 |
0.314 |
|
| 1986 |
Cushman M, Wong WC. Synthesis of a hypothetical intermediate in the biosynthesis of the 13-methylbenzophenanthridine alkaloids corynoline and 14-epicorynoline and the B-secoprotoberberine alkaloid corydalic acid methyl ester Tetrahedron Letters. 27: 2103-2106. DOI: 10.1016/S0040-4039(00)84459-7 |
0.328 |
|
| 1985 |
Cushman M, Mohan P. Synthesis and antitumor activity of structural analogues of the anticancer benzophenanthridine alkaloid fagaronine chloride Journal of Medicinal Chemistry. 28: 1031-1036. PMID 4020826 DOI: 10.1021/Jm00146A010 |
0.448 |
|
| 1985 |
Cushman M, Mohan P. The synthesis of a 4-phenylisoquinoline from a 3-phenylisoquinoline by utilization of a nitrogen analog of the pinacol rearrangement Tetrahedron Letters. 26: 4563-4566. DOI: 10.1016/S0040-4039(00)98752-5 |
0.302 |
|
| 1984 |
Cushman M, Mohan P, Smith ECR. Synthesis and biological activity of structural analogues of the anticancer benzophenanthridine alkaloid nitidine chloride. Journal of Medicinal Chemistry. 27: 544-547. PMID 6708057 DOI: 10.1021/Jm00370A021 |
0.405 |
|
| 1984 |
Cushman M, Abbaspour A. Utilization of magnesium chelates in the synthesis of 3-nitro- and 3-(methoxycarbonyl)-substituted 2-arylchromones Journal of Organic Chemistry. 49: 1280-1282. DOI: 10.1021/Jo00181A030 |
0.368 |
|
| 1984 |
Cushman M, Mohan P, Smith ECR. Synthesis And Biological Activity Of Structural Analogs Of The Anticancer Benzophenanthridine Alkaloid Nitidine Chloride Cheminform. 15. DOI: 10.1002/Chin.198438221 |
0.398 |
|
| 1984 |
Cushman M, Wong WC. Total Synthesis Of (.+-.)-Corydalic Acid Methyl Ester Cheminform. 15. DOI: 10.1002/Chin.198434205 |
0.308 |
|
| 1984 |
Cushman M, Abbaspour A. Utilization Of Magnesium Chelates In The Synthesis Of 3-Nitro- And 3-(Methoxycarbonyl)-Substituted 2-Arylchromones Cheminform. 15. DOI: 10.1002/Chin.198434199 |
0.368 |
|
| 1983 |
Ulrichová J, Walterová D, Preininger V, Slavík J, Lenfeld J, Cushman M, Šimánek V. Inhibition of acetylcholinesterase activity by some isoquinoline alkaloids. Planta Medica. 48: 111-115. PMID 6611748 DOI: 10.1055/S-2007-969901 |
0.365 |
|
| 1983 |
Cushman M, Abbaspour A, Gupta YP. Total synthesis of (.+-.)-14-epicorynoline, (.+-.)-corynoline, and (.+-.)-6-oxocorynoline Journal of the American Chemical Society. 105: 2873-2879. DOI: 10.1021/Ja00347A057 |
0.323 |
|
| 1982 |
Cushman M, Mathew J. Nitration of the Lithium Potassium Dianions of Phenolic Alkyl Aryl Ketones with Propyl Nitrate: Synthesis of 1-Nitroalkyl Hydroxyphenyl Ketones Synthesis. 1982: 397-399. DOI: 10.1055/S-1982-29811 |
0.338 |
|
| 1982 |
Cushman M, Mathew J. Novel Synthesis Of The Tetracyclic Ring System Present In Streptonigrin Cheminform. 13. DOI: 10.1002/Chin.198216349 |
0.35 |
|
| 1981 |
Cushman M, Mathew J. Novel synthesis of the tetracyclic ring system present in streptonigrin Journal of Organic Chemistry. 46: 4921-4923. DOI: 10.1021/Jo00337A019 |
0.35 |
|
| 1980 |
Cushman M, Choong T, Valko JT, Koleck MP. Total synthesis of (.+-.)-chelidonine Journal of Organic Chemistry. 45: 5067-5073. DOI: 10.1021/Jo01313A011 |
0.323 |
|
| 1980 |
Cushman M, Choong T, Valko JT, Koleck MP. A total synthesis of chelidonine Tetrahedron Letters. 21: 3845-3848. DOI: 10.1016/0040-4039(80)80196-1 |
0.307 |
|
| 1979 |
Cushman M, Dekow FW, Jacobsen LB. Conformations, DNA binding parameters, and antileukemic activity of certain cytotoxic protoberberine alkaloids Journal of Medicinal Chemistry. 22: 331-333. PMID 423218 DOI: 10.1021/Jm00189A025 |
0.337 |
|
| 1979 |
Cushman M, Dekow FW. Synthesis of (.+-.)-thalictricavine, berlambine, and (.+-.)-canadine from a common intermediate Journal of Organic Chemistry. 10: 407-409. DOI: 10.1021/Jo01317A020 |
0.331 |
|
| 1979 |
Cushman M, Dekow FW, Jacobsen LB. Conformations, Dna Binding Parameters, And Antileukemic Activity Of Certain Cytotoxic Protoberberine Alkaloids Cheminform. 10. DOI: 10.1002/Chin.197928329 |
0.303 |
|
| 1978 |
Cushman M, Cheng L. Total synthesis of nitidine chloride Journal of Organic Chemistry. 43: 286-288. DOI: 10.1021/Jo00396A024 |
0.329 |
|
| 1978 |
Cushman M, Dekow FW. A Total Synthesis Of Corydaline Tetrahedron. 34: 1435-1439. DOI: 10.1016/0040-4020(78)80162-8 |
0.312 |
|
| 1978 |
Cushman M, Cheng L. Total Synthesis Of Nitidine Chloride Cheminform. 9. DOI: 10.1002/Chin.197822316 |
0.329 |
|
| 1977 |
Anderegg R, Biemann K, Büchi G, Cushman M. Additions and Corrections - Malformin C, a New Metabolite of Aspergilus niger Journal of the American Chemical Society. 99: 5228-5228. DOI: 10.1021/Ja00457A600 |
0.642 |
|
| 1976 |
Anderegg RJ, Biemann K, Büchi G, Cushman M. Malformin C, a new metabolite of Aspergillus niger. Journal of the American Chemical Society. 98: 3365-70. PMID 1262650 DOI: 10.1021/Ja00427A051 |
0.64 |
|
| 1976 |
ANDEREGG RJ, BIEMANN K, BUECHI G, CUSHMAN M. ChemInform Abstract: MALFORMIN C, A NEW METABOLITE OF ASPERGILLUS NIGER Chemischer Informationsdienst. 7: no-no. DOI: 10.1002/Chin.197634317 |
0.493 |
|
| 1974 |
Cushman M, Castagnoli N. Synthesis of pharmacologically active nitrogen analogs of the tetrahydrocannabinols. The Journal of Organic Chemistry. 39: 1546-50. PMID 4833507 DOI: 10.1021/Jo00924A021 |
0.6 |
|
| 1974 |
Cushman M, Castagnoli NJ. Synthesis Of Pharmacologically Active Nitrogen Analogs Of The Tetrahydrocannabinols Cheminform. 5. DOI: 10.1002/Chin.197441434 |
0.395 |
|
| 1973 |
Cushman M, Castagnoli N. A novel approach to the synthesis of nitrogen analogs of the tetrahydrocannabinols. The Journal of Organic Chemistry. 38: 440-8. PMID 4687212 DOI: 10.1021/Jo00943A007 |
0.554 |
|
| 1972 |
Cushman M, Castagnoli N. The condensation of succinic anhydrides with Schiff bases. Scope and mechanism. The Journal of Organic Chemistry. 36: 3404-11. PMID 5132298 DOI: 10.1021/Jo00821A029 |
0.497 |
|
| 1972 |
Cushman M, Castagnoli N. Synthesis of trans-3'-methylnicotine The Journal of Organic Chemistry. 37: 1268-1271. DOI: 10.1021/Jo00973A046 |
0.56 |
|
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