Michael J. Holtzman - Publications

Affiliations: 
Washington University, Saint Louis, St. Louis, MO 
Area:
Cell Biology, Microbiology Biology, Molecular Biology, Public Health

196 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Zhang Y, Mao D, Keeler SP, Wang X, Wu K, Gerovac BJ, Shornick LL, Agapov EV, Holtzman MJ. Respiratory Enterovirus (Like Parainfluenza Virus) Can Cause Chronic Lung Disease If Protection by Airway Epithelial STAT1 Is Lost. Journal of Immunology (Baltimore, Md. : 1950). PMID 30804041 DOI: 10.4049/jimmunol.1801491  0.56
2018 Keeler SP, Gerovac BJ, Wu K, Wang X, Chartock JR, Byers DE, Romero AG, Holtzman MJ. Epithelial-Immune Cell Interactions for Drug Discovery in Chronic Obstructive Pulmonary Disease. Annals of the American Thoracic Society. 15: S260-S265. PMID 30759005 DOI: 10.1513/AnnalsATS.201808-531MG  0.36
2018 Keeler SP, Agapov EV, Hinojosa ME, Letvin AN, Wu K, Holtzman MJ. Influenza A Virus Infection Causes Chronic Lung Disease Linked to Sites of Active Viral RNA Remnants. Journal of Immunology (Baltimore, Md. : 1950). PMID 30209189 DOI: 10.4049/jimmunol.1800671  0.36
2018 Myung J, Schmal C, Hong S, Tsukizawa Y, Rose P, Zhang Y, Holtzman MJ, De Schutter E, Herzel H, Bordyugov G, Takumi T. The choroid plexus is an important circadian clock component. Nature Communications. 9: 1062. PMID 29540683 DOI: 10.1038/s41467-018-03507-2  0.56
2017 Siller SS, Sharma H, Li S, Yang J, Zhang Y, Holtzman MJ, Winuthayanon W, Colognato H, Holdener BC, Li FQ, Takemaru KI. Conditional knockout mice for the distal appendage protein CEP164 reveal its essential roles in airway multiciliated cell differentiation. Plos Genetics. 13: e1007128. PMID 29244804 DOI: 10.1371/journal.pgen.1007128  0.56
2017 Byers DE, Wu K, Dang-Vu G, Jin X, Agapov E, Zhang X, Battaile JT, Schechtman K, Yusen R, Pierce RA, Holtzman MJ. Triggering Receptor Expressed on Myeloid Cells-2 (TREM-2) expression tracks with M2-like macrophage activity and disease severity in COPD. Chest. PMID 29017955 DOI: 10.1016/j.chest.2017.09.044  0.36
2017 Benedetto R, Ousingsawat J, Wanitchakool P, Zhang Y, Holtzman MJ, Amaral M, Rock JR, Schreiber R, Kunzelmann K. Epithelial Chloride Transport by CFTR Requires TMEM16A. Scientific Reports. 7: 12397. PMID 28963502 DOI: 10.1038/s41598-017-10910-0  0.56
2017 Chatterjee S, Luthra P, Esaulova E, Agapov E, Yen BC, Borek DM, Edwards MR, Mittal A, Jordan DS, Ramanan P, Moore ML, Pappu RV, Holtzman MJ, Artyomov MN, Basler CF, et al. Structural basis for human respiratory syncytial virus NS1-mediated modulation of host responses. Nature Microbiology. 2: 17101. PMID 28665409 DOI: 10.1038/nmicrobiol.2017.101  0.32
2017 Li S, O'Neill SR, Zhang Y, Holtzman MJ, Takemaru KI, Korach KS, Winuthayanon W. Estrogen receptor α is required for oviductal transport of embryos. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 28082352 DOI: 10.1096/fj.201601128R  0.56
2017 Liu Y, Gunsten SP, Sultan DH, Luehmann HP, Zhao Y, Blackwell TS, Bollermann-Nowlis Z, Pan JH, Byers DE, Atkinson JJ, Kreisel D, Holtzman MJ, Gropler RJ, Combadiere C, Brody SL. PET-based Imaging of Chemokine Receptor 2 in Experimental and Disease-related Lung Inflammation. Radiology. 161409. PMID 28045644 DOI: 10.1148/radiol.2016161409  0.32
2016 Vindedal GF, Thoren AE, Jensen V, Klungland A, Zhang Y, Holtzman MJ, Ottersen OP, Nagelhus EA. Removal of aquaporin-4 from glial and ependymal membranes causes brain water accumulation. Molecular and Cellular Neurosciences. PMID 27751903 DOI: 10.1016/j.mcn.2016.10.004  0.56
2016 Olias P, Etheridge RD, Zhang Y, Holtzman MJ, Sibley LD. Toxoplasma Effector Recruits the Mi-2/NuRD Complex to Repress STAT1 Transcription and Block IFN-γ-Dependent Gene Expression. Cell Host & Microbe. 20: 72-82. PMID 27414498 DOI: 10.1016/j.chom.2016.06.006  0.56
2016 Lu Q, Yokoyama CC, Williams JW, Baldridge MT, Jin X, DesRochers B, Bricker T, Wilen CB, Bagaitkar J, Loginicheva E, Sergushichev A, Kreamalmeyer D, Keller BC, Zhao Y, Kambal A, ... ... Holtzman MJ, et al. Homeostatic Control of Innate Lung Inflammation by Vici Syndrome Gene Epg5 and Additional Autophagy Genes Promotes Influenza Pathogenesis. Cell Host & Microbe. 19: 102-113. PMID 26764600 DOI: 10.1016/j.chom.2015.12.011  0.56
2015 Zhang Y, Mao D, Roswit WT, Jin X, Patel AC, Patel DA, Agapov E, Wang Z, Tidwell RM, Atkinson JJ, Huang G, McCarthy R, Yu J, Yun NE, Paessler S, ... ... Holtzman MJ, et al. PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection. Nature Immunology. PMID 26479788 DOI: 10.1038/ni.3279  0.56
2015 Chen J, Zhao J, Chen L, Dong N, Ying Z, Cai Z, Ji D, Zhang Y, Dong L, Li Y, Jiang L, Holtzman MJ, Chen C. STAT1 modification improves therapeutic effects of interferons on lung cancer cells. Journal of Translational Medicine. 13: 293. PMID 26351076 DOI: 10.1186/s12967-015-0656-0  0.56
2015 Huang PH, Ren L, Nama N, Li S, Li P, Yao X, Cuento RA, Wei CH, Chen Y, Xie Y, Nawaz AA, Alevy YG, Holtzman MJ, McCoy JP, Levine SJ, et al. An acoustofluidic sputum liquefier. Lab On a Chip. 15: 3125-31. PMID 26082346 DOI: 10.1039/c5lc00539f  0.56
2015 Dickinson JD, Alevy Y, Malvin NP, Patel KK, Gunsten SP, Holtzman MJ, Stappenbeck TS, Brody SL. IL13 activates autophagy to regulate secretion in airway epithelial cells. Autophagy. 0. PMID 26062017 DOI: 10.1080/15548627.2015.1056967  0.56
2015 Wu K, Byers DE, Jin X, Agapov E, Alexander-Brett J, Patel AC, Cella M, Gilfilan S, Colonna M, Kober DL, Brett TJ, Holtzman MJ. TREM-2 promotes macrophage survival and lung disease after respiratory viral infection. The Journal of Experimental Medicine. 212: 681-97. PMID 25897174 DOI: 10.1084/jem.20141732  0.56
2015 Yurtsever Z, Scheaffer SM, Romero AG, Holtzman MJ, Brett TJ. The crystal structure of phosphorylated MAPK13 reveals common structural features and differences in p38 MAPK family activation. Acta Crystallographica. Section D, Biological Crystallography. 71: 790-9. PMID 25849390 DOI: 10.1107/S1399004715001212  0.56
2015 Lun MP, Johnson MB, Broadbelt KG, Watanabe M, Kang YJ, Chau KF, Springel MW, Malesz A, Sousa AM, Pletikos M, Adelita T, Calicchio ML, Zhang Y, Holtzman MJ, Lidov HG, et al. Spatially heterogeneous choroid plexus transcriptomes encode positional identity and contribute to regional CSF production. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 4903-16. PMID 25810521 DOI: 10.1523/JNEUROSCI.3081-14.2015  0.56
2015 Kim HJ, Kim CH, Kim MJ, Ryu JH, Seong SY, Kim S, Lim SJ, Holtzman MJ, Yoon JH. Duox2-derived Reactive Oxygen Species Induce Pattern Recognition Receptors' Expression Against Influenza A Virus in Nasal Mucosa. American Journal of Respiratory Cell and Molecular Biology. PMID 25751630 DOI: 10.1165/rcmb.2014-0334OC  0.56
2015 Barrow AD, Palarasah Y, Bugatti M, Holehouse AS, Byers DE, Holtzman MJ, Vermi W, Skjødt K, Crouch E, Colonna M. OSCAR is a receptor for surfactant protein D that activates TNF-α release from human CCR2+ inflammatory monocytes. Journal of Immunology (Baltimore, Md. : 1950). 194: 3317-26. PMID 25716998 DOI: 10.4049/jimmunol.1402289  0.56
2015 Gowdy KM, Martinu T, Nugent JL, Manzo ND, Zhang HL, Kelly FL, Holtzman MJ, Palmer SM. Impaired CD8(+) T cell immunity after allogeneic bone marrow transplantation leads to persistent and severe respiratory viral infection. Transplant Immunology. 32: 51-60. PMID 25446809 DOI: 10.1016/j.trim.2014.10.005  0.56
2015 Morales DJ, Monte K, Sun L, Struckhoff JJ, Agapov E, Holtzman MJ, Stappenbeck TS, Lenschow DJ. Novel mode of ISG15-mediated protection against influenza A virus and Sendai virus in mice. Journal of Virology. 89: 337-49. PMID 25320315 DOI: 10.1128/JVI.02110-14  0.56
2015 Alexander-Brett J, Holtzman MJ. Virus Infection of Airway Epithelial Cells Mucosal Immunology: Fourth Edition. 1: 1013-1021. DOI: 10.1016/B978-0-12-415847-4.00053-7  0.56
2014 Holtzman MJ, Byers DE, Brett JA, Patel AC, Agapov E, Jin X, Wu K. Linking acute infection to chronic lung disease. The role of IL-33-expressing epithelial progenitor cells. Annals of the American Thoracic Society. 11: S287-91. PMID 25525734 DOI: 10.1513/AnnalsATS.201402-056AW  0.56
2014 Holtzman MJ, Byers DE, Alexander-Brett J, Wang X. The role of airway epithelial cells and innate immune cells in chronic respiratory disease. Nature Reviews. Immunology. 14: 686-98. PMID 25234144 DOI: 10.1038/nri3739  0.56
2014 Patel DA, You Y, Huang G, Byers DE, Kim HJ, Agapov E, Moore ML, Peebles RS, Castro M, Sumino K, Shifren A, Brody SL, Holtzman MJ. Interferon response and respiratory virus control are preserved in bronchial epithelial cells in asthma. The Journal of Allergy and Clinical Immunology. 134: 1402-1412.e7. PMID 25216987 DOI: 10.1016/j.jaci.2014.07.013  0.56
2014 Pan JH, Adair-Kirk TL, Patel AC, Huang T, Yozamp NS, Xu J, Reddy EP, Byers DE, Pierce RA, Holtzman MJ, Brody SL. Myb permits multilineage airway epithelial cell differentiation. Stem Cells (Dayton, Ohio). 32: 3245-56. PMID 25103188 DOI: 10.1002/stem.1814  0.56
2014 Ebbinghaus M, Gajda M, Holtzman MJ, Schulz S, Schaible HG. Does chloride channel accessory 3 have a role in arthritis pain? A study on murine antigen-induced arthritis. Neuroscience Letters. 576: 40-4. PMID 24905173 DOI: 10.1016/j.neulet.2014.05.051  0.56
2014 Philippot Q, Deslée G, Adair-Kirk TL, Woods JC, Byers D, Conradi S, Dury S, Perotin JM, Lebargy F, Cassan C, Le Naour R, Holtzman MJ, Pierce RA. Increased iron sequestration in alveolar macrophages in chronic obstructive pulmonary disease. Plos One. 9: e96285. PMID 24789352 DOI: 10.1371/journal.pone.0096285  0.56
2014 Adler KB, Shapiro SD, Holtzman MJ, McDonald JA. The Red journal at 25 years. Looking back and looking ahead. American Journal of Respiratory Cell and Molecular Biology. 50: 839-40. PMID 24783952 DOI: 10.1165/rcmb.2014-0104ED  0.56
2014 Kober DL, Wanhainen KM, Johnson BM, Randolph DT, Holtzman MJ, Brett TJ. Preparation, crystallization, and preliminary crystallographic analysis of wild-type and mutant human TREM-2 ectodomains linked to neurodegenerative and inflammatory diseases. Protein Expression and Purification. 96: 32-8. PMID 24508568 DOI: 10.1016/j.pep.2014.01.015  0.56
2014 Gu X, Karp PH, Brody SL, Pierce RA, Welsh MJ, Holtzman MJ, Ben-Shahar Y. Chemosensory functions for pulmonary neuroendocrine cells. American Journal of Respiratory Cell and Molecular Biology. 50: 637-46. PMID 24134460 DOI: 10.1165/rcmb.2013-0199OC  0.56
2014 Patel DA, Patel AC, Nolan WC, Huang G, Romero AG, Charlton N, Agapov E, Zhang Y, Holtzman MJ. High-throughput screening normalized to biological response: application to antiviral drug discovery. Journal of Biomolecular Screening. 19: 119-30. PMID 23860224 DOI: 10.1177/1087057113496848  0.56
2013 Byers DE, Alexander-Brett J, Patel AC, Agapov E, Dang-Vu G, Jin X, Wu K, You Y, Alevy Y, Girard JP, Stappenbeck TS, Patterson GA, Pierce RA, Brody SL, Holtzman MJ. Long-term IL-33-producing epithelial progenitor cells in chronic obstructive lung disease. The Journal of Clinical Investigation. 123: 3967-82. PMID 23945235 DOI: 10.1172/JCI65570  0.56
2013 Kim HJ, Kim CH, Ryu JH, Kim MJ, Park CY, Lee JM, Holtzman MJ, Yoon JH. Reactive oxygen species induce antiviral innate immune response through IFN-λ regulation in human nasal epithelial cells. American Journal of Respiratory Cell and Molecular Biology. 49: 855-65. PMID 23786562 DOI: 10.1165/rcmb.2013-0003OC  0.56
2013 Li A, Chan B, Felix JC, Xing Y, Li M, Brody SL, Zhang Y, Holtzman MJ, Borok Z, Li C, Minoo P. Correction: Tissue-dependent consequences of Apc inactivation on proliferation and differentiation of ciliated cell progenitors via Wnt and notch signaling (PLoS ONE) Plos One. 8. DOI: 10.1371/annotation/79fc47f5-11a5-4ef3-a80e-e2c5af62c5c1  0.56
2012 Alevy YG, Patel AC, Romero AG, Patel DA, Tucker J, Roswit WT, Miller CA, Heier RF, Byers DE, Brett TJ, Holtzman MJ. IL-13-induced airway mucus production is attenuated by MAPK13 inhibition. The Journal of Clinical Investigation. 122: 4555-68. PMID 23187130 DOI: 10.1172/JCI64896  0.56
2012 Yurtsever Z, Sala-Rabanal M, Randolph DT, Scheaffer SM, Roswit WT, Alevy YG, Patel AC, Heier RF, Romero AG, Nichols CG, Holtzman MJ, Brett TJ. Self-cleavage of human CLCA1 protein by a novel internal metalloprotease domain controls calcium-activated chloride channel activation. The Journal of Biological Chemistry. 287: 42138-49. PMID 23112050 DOI: 10.1074/jbc.M112.410282  0.56
2012 Page C, Goicochea L, Matthews K, Zhang Y, Klover P, Holtzman MJ, Hennighausen L, Frieman M. Induction of alternatively activated macrophages enhances pathogenesis during severe acute respiratory syndrome coronavirus infection. Journal of Virology. 86: 13334-49. PMID 23015710 DOI: 10.1128/JVI.01689-12  0.56
2012 Holtzman MJ. Asthma as a chronic disease of the innate and adaptive immune systems responding to viruses and allergens. The Journal of Clinical Investigation. 122: 2741-8. PMID 22850884 DOI: 10.1172/JCI60325  0.56
2012 Brown SM, Campbell SD, Crafford A, Regina KJ, Holtzman MJ, Kharasch ED. P-glycoprotein is a major determinant of norbuprenorphine brain exposure and antinociception. The Journal of Pharmacology and Experimental Therapeutics. 343: 53-61. PMID 22739506 DOI: 10.1124/jpet.112.193433  0.56
2012 Patel DA, Patel AC, Nolan WC, Zhang Y, Holtzman MJ. High throughput screening for small molecule enhancers of the interferon signaling pathway to drive next-generation antiviral drug discovery. Plos One. 7: e36594. PMID 22574190 DOI: 10.1371/journal.pone.0036594  0.56
2012 Sumino K, Tucker J, Shahab M, Jaffee KF, Visness CM, Gern JE, Bloomberg GR, Holtzman MJ. Antiviral IFN-γ responses of monocytes at birth predict respiratory tract illness in the first year of life. The Journal of Allergy and Clinical Immunology. 129: 1267-1273.e1. PMID 22460071 DOI: 10.1016/j.jaci.2012.02.033  0.56
2012 Wang W, Nguyen NM, Agapov E, Holtzman MJ, Woods JC. Monitoring in vivo changes in lung microstructure with ³He MRI in Sendai virus-infected mice. Journal of Applied Physiology (Bethesda, Md. : 1985). 112: 1593-9. PMID 22383505 DOI: 10.1152/japplphysiol.01165.2011  0.56
2012 Lobas MA, Helsper L, Vernon CG, Schreiner D, Zhang Y, Holtzman MJ, Thedens DR, Weiner JA. Molecular heterogeneity in the choroid plexus epithelium: the 22-member γ-protocadherin family is differentially expressed, apically localized, and implicated in CSF regulation. Journal of Neurochemistry. 120: 913-27. PMID 22092001 DOI: 10.1111/j.1471-4159.2011.07587.x  0.56
2011 Fu H, Patel AC, Holtzman MJ, Chen DR. A New Electrospray Aerosol Generator with High Particle Transmission Efficiency. Aerosol Science and Technology : the Journal of the American Association For Aerosol Research. 45: 1176-1183. PMID 22829715 DOI: 10.1080/02786826.2011.582899  0.56
2011 Byers DE, Holtzman MJ. Alternatively activated macrophages and airway disease. Chest. 140: 768-74. PMID 21896520 DOI: 10.1378/chest.10-2132  0.56
2011 Holtzman MJ, Patel DA, Zhang Y, Patel AC. Host epithelial-viral interactions as cause and cure for asthma. Current Opinion in Immunology. 23: 487-94. PMID 21703838 DOI: 10.1016/j.coi.2011.05.010  0.56
2011 Jacquet BV, Muthusamy N, Sommerville LJ, Xiao G, Liang H, Zhang Y, Holtzman MJ, Ghashghaei HT. Specification of a Foxj1-dependent lineage in the forebrain is required for embryonic-to-postnatal transition of neurogenesis in the olfactory bulb. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 9368-82. PMID 21697387 DOI: 10.1523/JNEUROSCI.0171-11.2011  0.56
2011 Patel AC, Brody SL, Stappenbeck TS, Holtzman MJ. Tracking cell lineage to rediscover (again) the switch from ciliated to mucous cells. American Journal of Respiratory Cell and Molecular Biology. 44: 261-3. PMID 21364232 DOI: 10.1165/rcmb.2011-0021ED  0.56
2011 Le Cras TD, Acciani TH, Mushaben EM, Kramer EL, Pastura PA, Hardie WD, Korfhagen TR, Sivaprasad U, Ericksen M, Gibson AM, Holtzman MJ, Whitsett JA, Hershey GK. Epithelial EGF receptor signaling mediates airway hyperreactivity and remodeling in a mouse model of chronic asthma. American Journal of Physiology. Lung Cellular and Molecular Physiology. 300: L414-21. PMID 21224214 DOI: 10.1152/ajplung.00346.2010  0.56
2010 Zhang Y, Hinojosa ME, Yoo N, Holtzman MJ. Viral and host strategies to take advantage of the innate immune response. American Journal of Respiratory Cell and Molecular Biology. 43: 507-10. PMID 20971885 DOI: 10.1165/rcmb.2009-0213ED  0.56
2010 Cheung DS, Ehlenbach SJ, Kitchens RT, Riley DA, Thomas LL, Holtzman MJ, Grayson MH. Cutting edge: CD49d+ neutrophils induce FcepsilonRI expression on lung dendritic cells in a mouse model of postviral asthma. Journal of Immunology (Baltimore, Md. : 1950). 185: 4983-7. PMID 20876348 DOI: 10.4049/jimmunol.1002456  0.56
2010 Sumino KC, Walter MJ, Mikols CL, Thompson SA, Gaudreault-Keener M, Arens MQ, Agapov E, Hormozdi D, Gaynor AM, Holtzman MJ, Storch GA. Detection of respiratory viruses and the associated chemokine responses in serious acute respiratory illness. Thorax. 65: 639-44. PMID 20627924 DOI: 10.1136/thx.2009.132480  0.56
2010 Byers DE, Holtzman MJ. Alternatively activated macrophages as cause or effect in airway disease. American Journal of Respiratory Cell and Molecular Biology. 43: 1-4. PMID 20587775 DOI: 10.1165/rcmb.2009-0407ED  0.56
2010 Edelson BT, KC W, Juang R, Kohyama M, Benoit LA, Klekotka PA, Moon C, Albring JC, Ise W, Michael DG, Bhattacharya D, Stappenbeck TS, Holtzman MJ, Sung SS, Murphy TL, et al. Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8alpha+ conventional dendritic cells. The Journal of Experimental Medicine. 207: 823-36. PMID 20351058 DOI: 10.1084/jem.20091627  0.56
2010 Benoit LA, Holtzman MJ. New immune pathways from chronic post-viral lung disease. Annals of the New York Academy of Sciences. 1183: 195-210. PMID 20146716 DOI: 10.1111/j.1749-6632.2009.05136.x  0.56
2010 Gitlin L, Benoit L, Song C, Cella M, Gilfillan S, Holtzman MJ, Colonna M. Melanoma differentiation-associated gene 5 (MDA5) is involved in the innate immune response to Paramyxoviridae infection in vivo. Plos Pathogens. 6: e1000734. PMID 20107606 DOI: 10.1371/journal.ppat.1000734  0.56
2010 Deslee G, Adair-Kirk TL, Betsuyaku T, Woods JC, Moore CH, Gierada DS, Conradi SH, Atkinson JJ, Toennies HM, Battaile JT, Kobayashi DK, Patterson GA, Holtzman MJ, Pierce RA. Cigarette smoke induces nucleic-acid oxidation in lung fibroblasts. American Journal of Respiratory Cell and Molecular Biology. 43: 576-84. PMID 20008282 DOI: 10.1165/rcmb.2009-0221OC  0.56
2009 Tachdjian R, Mathias C, Al Khatib S, Bryce PJ, Kim HS, Blaeser F, O'Connor BD, Rzymkiewicz D, Chen A, Holtzman MJ, Hershey GK, Garn H, Harb H, Renz H, Oettgen HC, et al. Pathogenicity of a disease-associated human IL-4 receptor allele in experimental asthma. The Journal of Experimental Medicine. 206: 2191-204. PMID 19770271 DOI: 10.1084/jem.20091480  0.56
2009 Demehri S, Morimoto M, Holtzman MJ, Kopan R. Skin-derived TSLP triggers progression from epidermal-barrier defects to asthma. Plos Biology. 7: e1000067. PMID 19557146 DOI: 10.1371/journal.pbio.1000067  0.56
2009 Agapov E, Battaile JT, Tidwell R, Hachem R, Patterson GA, Pierce RA, Atkinson JJ, Holtzman MJ. Macrophage chitinase 1 stratifies chronic obstructive lung disease. American Journal of Respiratory Cell and Molecular Biology. 41: 379-84. PMID 19491341 DOI: 10.1165/2009-0122R  0.56
2009 Holtzman MJ, Byers DE, Benoit LA, Battaile JT, You Y, Agapov E, Park C, Grayson MH, Kim EY, Patel AC. Immune pathways for translating viral infection into chronic airway disease. Advances in Immunology. 102: 245-76. PMID 19477323 DOI: 10.1016/S0065-2776(09)01205-X  0.56
2009 Deslee G, Woods JC, Moore CM, Liu L, Conradi SH, Milne M, Gierada DS, Pierce J, Patterson A, Lewit RA, Battaile JT, Holtzman MJ, Hogg JC, Pierce RA. Elastin expression in very severe human COPD. The European Respiratory Journal. 34: 324-31. PMID 19357152 DOI: 10.1183/09031936.00123008  0.56
2009 Deslee G, Woods JC, Moore C, Conradi SH, Gierada DS, Atkinson JJ, Battaile JT, Liu L, Patterson GA, Adair-Kirk TL, Holtzman MJ, Pierce RA. Oxidative damage to nucleic acids in severe emphysema. Chest. 135: 965-74. PMID 19118262 DOI: 10.1378/chest.08-2257  0.56
2009 Patel AC, Brett TJ, Holtzman MJ. The role of CLCA proteins in inflammatory airway disease. Annual Review of Physiology. 71: 425-49. PMID 18954282 DOI: 10.1146/annurev.physiol.010908.163253  0.56
2008 Kim EY, Battaile JT, Patel AC, You Y, Agapov E, Grayson MH, Benoit LA, Byers DE, Alevy Y, Tucker J, Swanson S, Tidwell R, Tyner JW, Morton JD, Castro M, ... ... Holtzman MJ, et al. Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease. Nature Medicine. 14: 633-40. PMID 18488036 DOI: 10.1038/nm1770  0.56
2008 Fujisawa T, Ide K, Holtzman MJ, Suda T, Suzuki K, Kuroishi S, Chida K, Nakamura H. Involvement of the p38 MAPK pathway in IL-13-induced mucous cell metaplasia in mouse tracheal epithelial cells. Respirology (Carlton, Vic.). 13: 191-202. PMID 18339016 DOI: 10.1111/j.1440-1843.2008.01237.x  0.56
2008 Akk AM, Simmons PM, Chan HW, Agapov E, Holtzman MJ, Grayson MH, Pham CT. Dipeptidyl peptidase I-dependent neutrophil recruitment modulates the inflammatory response to Sendai virus infection. Journal of Immunology (Baltimore, Md. : 1950). 180: 3535-42. PMID 18292580  0.56
2008 Shornick LP, Wells AG, Zhang Y, Patel AC, Huang G, Takami K, Sosa M, Shukla NA, Agapov E, Holtzman MJ. Airway epithelial versus immune cell Stat1 function for innate defense against respiratory viral infection. Journal of Immunology (Baltimore, Md. : 1950). 180: 3319-28. PMID 18292557  0.56
2007 Grayson MH, Cheung D, Rohlfing MM, Kitchens R, Spiegel DE, Tucker J, Battaile JT, Alevy Y, Yan L, Agapov E, Kim EY, Holtzman MJ. Induction of high-affinity IgE receptor on lung dendritic cells during viral infection leads to mucous cell metaplasia. The Journal of Experimental Medicine. 204: 2759-69. PMID 17954569 DOI: 10.1084/jem.20070360  0.56
2007 Grayson MH, Holtzman MJ. Emerging role of dendritic cells in respiratory viral infection. Journal of Molecular Medicine (Berlin, Germany). 85: 1057-68. PMID 17891367 DOI: 10.1007/s00109-007-0212-3  0.56
2007 Grayson MH, Ramos MS, Rohlfing MM, Kitchens R, Wang HD, Gould A, Agapov E, Holtzman MJ. Controls for lung dendritic cell maturation and migration during respiratory viral infection. Journal of Immunology (Baltimore, Md. : 1950). 179: 1438-48. PMID 17641009  0.56
2007 Stout BA, Melendez K, Seagrave J, Holtzman MJ, Wilson B, Xiang J, Tesfaigzi Y. STAT1 activation causes translocation of Bax to the endoplasmic reticulum during the resolution of airway mucous cell hyperplasia by IFN-gamma. Journal of Immunology (Baltimore, Md. : 1950). 178: 8107-16. PMID 17548649  0.56
2007 Cohen L, E X, Tarsi J, Ramkumar T, Horiuchi TK, Cochran R, DeMartino S, Schechtman KB, Hussain I, Holtzman MJ, Castro M. Epithelial cell proliferation contributes to airway remodeling in severe asthma. American Journal of Respiratory and Critical Care Medicine. 176: 138-45. PMID 17463414 DOI: 10.1164/rccm.200607-1062OC  0.56
2007 Kwon MJ, Yao Y, Walter MJ, Holtzman MJ, Chang CH. Role of PKCdelta in IFN-gamma-inducible CIITA gene expression. Molecular Immunology. 44: 2841-9. PMID 17346795 DOI: 10.1016/j.molimm.2007.01.035  0.56
2007 Zhang Y, Huang G, Shornick LP, Roswit WT, Shipley JM, Brody SL, Holtzman MJ. A transgenic FOXJ1-Cre system for gene inactivation in ciliated epithelial cells. American Journal of Respiratory Cell and Molecular Biology. 36: 515-9. PMID 17255554 DOI: 10.1165/rcmb.2006-0475RC  0.56
2006 Lin W, Kim SS, Yeung E, Kamegaya Y, Blackard JT, Kim KA, Holtzman MJ, Chung RT. Hepatitis C virus core protein blocks interferon signaling by interaction with the STAT1 SH2 domain. Journal of Virology. 80: 9226-35. PMID 16940534 DOI: 10.1128/JVI.00459-06  0.56
2006 Grayson MH, Holtzman MJ. Chemokine complexity: the case for CCL5. American Journal of Respiratory Cell and Molecular Biology. 35: 143-6. PMID 16847105 DOI: 10.1165/rcmb.f318  0.56
2006 Ibricevic A, Pekosz A, Walter MJ, Newby C, Battaile JT, Brown EG, Holtzman MJ, Brody SL. Influenza virus receptor specificity and cell tropism in mouse and human airway epithelial cells. Journal of Virology. 80: 7469-80. PMID 16840327 DOI: 10.1128/JVI.02677-05  0.56
2006 Patel AC, Morton JD, Kim EY, Alevy Y, Swanson S, Tucker J, Huang G, Agapov E, Phillips TE, Fuentes ME, Iglesias A, Aud D, Allard JD, Dabbagh K, Peltz G, ... Holtzman MJ, et al. Genetic segregation of airway disease traits despite redundancy of calcium-activated chloride channel family members. Physiological Genomics. 25: 502-13. PMID 16569774 DOI: 10.1152/physiolgenomics.00321.2005  0.56
2006 Deppong C, Juehne TI, Hurchla M, Friend LD, Shah DD, Rose CM, Bricker TL, Shornick LP, Crouch EC, Murphy TL, Holtzman MJ, Murphy KM, Green JM. Cutting edge: B and T lymphocyte attenuator and programmed death receptor-1 inhibitory receptors are required for termination of acute allergic airway inflammation. Journal of Immunology (Baltimore, Md. : 1950). 176: 3909-13. PMID 16547224  0.56
2006 Holtzman MJ, Battaile JT, Patel AC. Immunogenetic programs for viral induction of mucous cell metaplasia. American Journal of Respiratory Cell and Molecular Biology. 35: 29-39. PMID 16543602 DOI: 10.1165/rcmb.2006-0092SF  0.56
2006 Grayson MH, Holtzman MJ. Chemokine signaling regulates apoptosis as well as immune cell traffic in host defense. Cell Cycle (Georgetown, Tex.). 5: 380-3. PMID 16479157 DOI: 10.4161/cc.5.4.2427  0.56
2006 Tyner JW, Kim EY, Ide K, Pelletier MR, Roswit WT, Morton JD, Battaile JT, Patel AC, Patterson GA, Castro M, Spoor MS, You Y, Brody SL, Holtzman MJ. Blocking airway mucous cell metaplasia by inhibiting EGFR antiapoptosis and IL-13 transdifferentiation signals. The Journal of Clinical Investigation. 116: 309-21. PMID 16453019 DOI: 10.1172/JCI25167  0.56
2006 Agapov E, Sumino KC, Gaudreault-Keener M, Storch GA, Holtzman MJ. Genetic variability of human metapneumovirus infection: evidence of a shift in viral genotype without a change in illness. The Journal of Infectious Diseases. 193: 396-403. PMID 16388487 DOI: 10.1086/499310  0.56
2005 Tyner JW, Uchida O, Kajiwara N, Kim EY, Patel AC, O'Sullivan MP, Walter MJ, Schwendener RA, Cook DN, Danoff TM, Holtzman MJ. CCL5-CCR5 interaction provides antiapoptotic signals for macrophage survival during viral infection. Nature Medicine. 11: 1180-7. PMID 16208318 DOI: 10.1038/nm1303  0.56
2005 Holtzman MJ, Tyner JW, Kim EY, Lo MS, Patel AC, Shornick LP, Agapov E, Zhang Y. Acute and chronic airway responses to viral infection: implications for asthma and chronic obstructive pulmonary disease. Proceedings of the American Thoracic Society. 2: 132-40. PMID 16113481 DOI: 10.1513/pats.200502-015AW  0.56
2005 Sumino KC, Agapov E, Pierce RA, Trulock EP, Pfeifer JD, Ritter JH, Gaudreault-Keener M, Storch GA, Holtzman MJ. Detection of severe human metapneumovirus infection by real-time polymerase chain reaction and histopathological assessment. The Journal of Infectious Diseases. 192: 1052-60. PMID 16107959 DOI: 10.1086/432728  0.56
2005 Zhang Y, Takami K, Lo MS, Huang G, Yu Q, Roswit WT, Holtzman MJ. Modification of the Stat1 SH2 domain broadly improves interferon efficacy in proportion to p300/CREB-binding protein coactivator recruitment. The Journal of Biological Chemistry. 280: 34306-15. PMID 16107341 DOI: 10.1074/jbc.M503263200  0.56
2005 Holtzman MJ, Kim EY, Lo MS, Tyner JW, Shornick LP, Sumino KC, Zhang Y. Defining and adjusting divergent host responses to viral infection. Immunologic Research. 32: 123-41. PMID 16106064 DOI: 10.1385/IR:32:1-3:123  0.56
2005 Lo MS, Brazas RM, Holtzman MJ. Respiratory syncytial virus nonstructural proteins NS1 and NS2 mediate inhibition of Stat2 expression and alpha/beta interferon responsiveness. Journal of Virology. 79: 9315-9. PMID 15994826 DOI: 10.1128/JVI.79.14.9315-9319.2005  0.56
2005 Walter MJ, Holtzman MJ. A centennial history of research on asthma pathogenesis. American Journal of Respiratory Cell and Molecular Biology. 32: 483-9. PMID 15901618 DOI: 10.1165/rcmb.F300  0.56
2005 Holtzman MJ. Airway responses to respiratory viruses: Chairman's summary Proceedings of the American Thoracic Society. 2: 108-109. DOI: 10.1513/pats.200506-050AW  0.56
2005 Holtzman MJ, Kim EY, Morton JD. Genetic and genomic approaches to complex lung diseases using mouse models Computational Genetics and Genomics: Tools For Understanding Disease. 103-145. DOI: 10.1007/978-1-59259-930-1_6  0.56
2004 Holtzman MJ, Shornick LP, Grayson MH, Kim EY, Tyner JW, Patel AC, Agapov E, Zhang Y. "Hit-and-run" effects of paramyxoviruses as a basis for chronic respiratory disease. The Pediatric Infectious Disease Journal. 23: S235-45. PMID 15577579 DOI: 10.1097/01.inf.0000144674.24802.c1  0.56
2004 Chang YJ, Holtzman MJ, Chen CC. Differential role of Janus family kinases (JAKs) in interferon-gamma-induced lung epithelial ICAM-1 expression: involving protein interactions between JAKs, phospholipase Cgamma, c-Src, and STAT1. Molecular Pharmacology. 65: 589-98. PMID 14978237 DOI: 10.1124/mol.65.3.589  0.56
2004 Castro M, Bloch SR, Jenkerson MV, DeMartino S, Hamilos DL, Cochran RB, Zhang XE, Wang H, Bradley JP, Schechtman KB, Holtzman MJ. Asthma exacerbations after glucocorticoid withdrawal reflects T cell recruitment to the airway. American Journal of Respiratory and Critical Care Medicine. 169: 842-9. PMID 14726420 DOI: 10.1164/rccm.200208-960OC  0.56
2003 Holtzman MJ. Drug development for asthma. American Journal of Respiratory Cell and Molecular Biology. 29: 163-71. PMID 12878583 DOI: 10.1165/rcmb.F276  0.56
2003 O'Sullivan MP, Tyner JW, Holtzman MJ. Apoptosis in the airways: another balancing act in the epithelial program. American Journal of Respiratory Cell and Molecular Biology. 29: 3-7. PMID 12821445 DOI: 10.1165/rcmb.F273  0.56
2003 Holtzman MJ. Transition, sunlight, and the art of journal maintenance. American Journal of Respiratory Cell and Molecular Biology. 29: 1-2. PMID 12821444 DOI: 10.1165/rcmb.F275  0.56
2003 Huang Xl, Pawliczak R, Yao Xl, Cowan MJ, Gladwin MT, Walter MJ, Holtzman MJ, Madara P, Logun C, Shelhamer JH. Interferon-γ induces p11 gene and protein expression in human epithelial cells through interferon-γ-activated sequences in the p11 promoter Journal of Biological Chemistry. 278: 9298-9308. PMID 12645529 DOI: 10.1074/jbc.M212704200  0.56
2003 Holtzman MJ, Agapov E, Kim E, Kim JI, Morton JD. Developing the epithelial, viral, and allergic paradigm for asthma: Giles F. Filley lecture. Chest. 123: 377S-84S. PMID 12628993  0.56
2003 Holtzman MJ. Where are the gaps in asthma research? A counter-perspective. The Journal of Allergy and Clinical Immunology. 111: 244-7. PMID 12589339 DOI: 10.1067/mai.2003.141  0.56
2003 Grayson MH, Hotchkiss RS, Karl IE, Holtzman MJ, Chaplin DD. Intravital microscopy comparing T lymphocyte trafficking to the spleen and the mesenteric lymph node. American Journal of Physiology. Heart and Circulatory Physiology. 284: H2213-26. PMID 12586641 DOI: 10.1152/ajpheart.00999.2002  0.56
2002 Stephens R, Randolph DA, Huang G, Holtzman MJ, Chaplin DD. Antigen-nonspecific recruitment of Th2 cells to the lung as a mechanism for viral infection-induced allergic asthma. Journal of Immunology (Baltimore, Md. : 1950). 169: 5458-67. PMID 12421921  0.56
2002 Walter MJ, Morton JD, Kajiwara N, Agapov E, Holtzman MJ. Viral induction of a chronic asthma phenotype and genetic segregation from the acute response. The Journal of Clinical Investigation. 110: 165-75. PMID 12122108 DOI: 10.1172/JCI14345  0.56
2002 Iregui M, Malen J, Tuteur P, Lynch J, Holtzman MJ, Kollef MH. Determinants of outcome for patients admitted to a long-term ventilator unit. Southern Medical Journal. 95: 310-7. PMID 11902697  0.56
2002 Holtzman MJ, Morton JD, Shornick LP, Tyner JW, O'Sullivan MP, Antao A, Lo M, Castro M, Walter MJ. Immunity, inflammation, and remodeling in the airway epithelial barrier: epithelial-viral-allergic paradigm. Physiological Reviews. 82: 19-46. PMID 11773608 DOI: 10.1152/physrev.00020.2001  0.56
2002 Chang YJ, Holtzman MJ, Chen CC. Interferon-gamma-induced epithelial ICAM-1 expression and monocyte adhesion. Involvement of protein kinase C-dependent c-Src tyrosine kinase activation pathway. The Journal of Biological Chemistry. 277: 7118-26. PMID 11751911 DOI: 10.1074/jbc.M109924200  0.56
2002 Grayson MH, Holtzman MJ. Lessons from allergic rhinitis versus asthma pathogenesis and treatment Immunology and Allergy Clinics of North America. 22: 845-869. DOI: 10.1016/S0889-8561(02)00027-9  0.56
2002 Holtzman MJ. Improving peer review and introducing translational review American Journal of Respiratory Cell and Molecular Biology. 27: 1-2.  0.56
2001 Anderson GJ, Roswit WT, Holtzman MJ, Hogg JC, Van Eeden SF. Effect of mechanical deformation of neutrophils on their CD18/ICAM-1-dependent adhesion Journal of Applied Physiology. 91: 1084-1090. PMID 11509502  0.56
2001 Walter MJ, Kajiwara N, Karanja P, Castro M, Holtzman MJ. Interleukin 12 p40 production by barrier epithelial cells during airway inflammation Journal of Experimental Medicine. 193: 339-351. PMID 11157054 DOI: 10.1084/jem.193.3.339  0.56
2001 Holtzman MJ. Electronics, people, and the art of publication American Journal of Respiratory Cell and Molecular Biology. 25: 1-2.  0.56
2000 Holtzman MJ, Green JM, Jayaraman S, Arch RH. Regulation of T cell apoptosis Apoptosis. 5: 459-471. PMID 11256889 DOI: 10.1023/A:1009657321461  0.56
2000 Shen X, Tian Z, Holtzman MJ, Gao B. Cross-talk between interleukin 1β (IL-1β) and IL-6 signalling pathways: IL-1β selectively inhibits IL-6-activated signal transducer and activator of transcription factor 1 (STAT1) by a proteasome-dependent mechanism Biochemical Journal. 352: 913-919. PMID 11104703 DOI: 10.1042/0264-6021:3520913  0.56
2000 Holtzman MJ. Perennial goals for the millennium American Journal of Respiratory Cell and Molecular Biology. 23: 1-2. PMID 10873145  0.56
2000 Castro M, Chaplin DD, Walter MJ, Holtzman MJ. Could asthma be worsened by stimulating the T-helper type 1 immune response? American Journal of Respiratory Cell and Molecular Biology. 22: 143-146. PMID 10657933  0.56
1999 Koga T, Sardiña E, Tidwell RM, Pelletier M, Look DC, Holtzman MJ. Virus-inducible expression of a host chemokine gene relies on replication-linked mRNA stabilization Proceedings of the National Academy of Sciences of the United States of America. 96: 5680-5685. PMID 10318944 DOI: 10.1073/pnas.96.10.5680  0.56
1999 Sampath D, Castro M, Look DC, Holtzman MJ. Constitutive activation of an epithelial signal transducer and activator of transcription (STAT) pathway in asthma. The Journal of Clinical Investigation. 103: 1353-61. PMID 10225979 DOI: 10.1172/JCI6130  0.56
1999 Jayaraman S, Castro M, O'Sullivan M, Bragdon MJ, Holtzman MJ. Resistance to Fas-mediated T cell apoptosis in asthma Journal of Immunology. 162: 1717-1722. PMID 9973434  0.56
1998 Look DC, Roswit WT, Frick AG, Gris-Alevy Y, Dickhaus DM, Walter MJ, Holtzman MJ. Direct suppression of Stat1 function during adenoviral infection. Immunity. 9: 871-80. PMID 9881977 DOI: 10.1016/S1074-7613(00)80652-4  0.56
1998 Holtzman MJ. Matching scientific with societal interests: charges for the new editor American Journal of Respiratory Cell and Molecular Biology. 19: 1-2. PMID 9651173  0.56
1998 Taguchi M, Sampath D, Koga T, Castro M, Look DC, Nakajima S, Holtzman MJ. Patterns for RANTES secretion and intercellular adhesion molecule 1 expression mediate transepithelial T cell traffic based on analyses in vitro and in vivo. The Journal of Experimental Medicine. 187: 1927-40. PMID 9625753 DOI: 10.1084/jem.187.12.1927  0.56
1998 Holtzman MJ, Look DC, Sampath D, Castro M, Koga T, Walter MJ. Control of epithelial immune-response genes and implications for airway immunity and inflammation. Proceedings of the Association of American Physicians. 110: 1-11. PMID 9460078  0.56
1998 Sardifia E, Tidwell R, Koga T, Holtzman MJ. Regulation of rantes gene expression by a 3′-utr that lacks consensus sites for mrna turnover Faseb Journal. 12.  0.56
1998 Walter MJ, Kajiwara N, Sampath D, Rucker J, Holtzman MJ. Induction of epithelial immune-response genes in a mouse model of viral bronchitis and hyperreactivity Faseb Journal. 12.  0.56
1998 Sampaih DD, Roswit WT, Koga T, Waller MJ, Look PC, Castro M, Holtzman MJ. Autoamplification of stat 1-dependent gene expression Faseb Journal. 12.  0.56
1998 Tsuchida T, Tanaka M, Okunaka T, Nakajima S, Nakajima R, Konaka C, Kato H, Azuma A, Kudoh S, Yamamoto M, Izumi T, Ando M, Abe S, Sugawara I, Takizawa H, ... ... Holtzman MJ, et al. General discussion on present the knowledge concerning small airways Journal of Tokyo Medical University. 56: 438-451.  0.56
1997 Walter MJ, Look DC, Tidwell RM, Roswit WT, Holtzman MJ. Targeted inhibition of interferon-γ-dependent intercellular adhesion molecule-1 (ICAM-1) expression using dominant-negative Stat1 Journal of Biological Chemistry. 272: 28582-28589. PMID 9353323 DOI: 10.1074/jbc.272.45.28582  0.56
1996 Zhang V, O'Sullivan M, Hussain H, Roswit WT, Holtzman MJ. Molecular cloning, functional expression, and selective regulation of ovine prostaglandin H synthase-2. Biochemical and Biophysical Research Communications. 227: 499-506. PMID 8878543 DOI: 10.1006/bbrc.1996.1536  0.56
1996 Holtzman MJ, Sampath D, Castro M, Look DC, Jayaraman S. The one-two of T helper cells: does interferon-gamma knock out the Th2 hypothesis for asthma? American Journal of Respiratory Cell and Molecular Biology. 14: 316-8. PMID 8600934 DOI: 10.1165/ajrcmb.14.4.8600934  0.56
1995 Look DC, Pelletier MB, Tidwell RM, Roswit WT, Holtzman MJ. Stat1 depends on transcriptional synergy with Sp1 Journal of Biological Chemistry. 270: 30264-30267. PMID 8530443 DOI: 10.1074/jbc.270.51.30264  0.56
1995 Holtzman MJ, Brody SL, Look DC. Does gene therapy call for "STAT" immunity and inflammation at the epithelial barrier? American Journal of Respiratory Cell and Molecular Biology. 12: 127-129. PMID 7865211  0.56
1995 Nakajima S, Roswit WT, Look DC, Holtzman MJ. A hierarchy for integrin expression and adhesiveness among T cell subsets that is linked to TCR gene usage and emphasizes Vδ1+ γδ T cell adherence and tissue retention Journal of Immunology. 155: 1117-1131. PMID 7636183  0.56
1994 Hussain H, Shornick LP, Shannon VR, Wilson JD, Funk CD, Pentland AP, Holtzman MJ. Epidermis contains platelet-type 12-lipoxygenase that is overexpressed in germinal layer keratinocytes in psoriasis. The American Journal of Physiology. 266: C243-53. PMID 8304420  0.56
1994 Dean DC, Weintraub SJ, Holtzman MJ. A molecular switch between lung development and cancer: is the tumor suppressor Rb turned on during bronchial epithelial cell differentiation and turned off in small cell lung cancer? American Journal of Respiratory Cell and Molecular Biology. 11: 249-50. PMID 8086162 DOI: 10.1165/ajrcmb.11.3.8086162  0.56
1994 Look DC, Pelletier MR, Holtzman MJ. Selective interaction of a subset of interferon-γ response element-binding proteins with the intercellular adhesion molecule-1 (ICAM-1) gene promoter controls the pattern of expression on epithelial cells Journal of Biological Chemistry. 269: 8952-8958. PMID 7907595  0.56
1994 Holtzman MJ, Zhang V, Hussain H, Roswit WT, Wilson JD. Prostaglandin H synthase and lipoxygenase gene families in the epithelial cell barrier. Annals of the New York Academy of Sciences. 744: 58-77. PMID 7825863 DOI: 10.1111/j.1749-6632.1994.tb52724.x  0.56
1994 Nakajima S, Look DC, Roswit WT, Bragdon MJ, Holtzman MJ. Selective differences in vascular endothelial- vs. airway epithelial-T cell adhesion mechanisms American Journal of Physiology - Lung Cellular and Molecular Physiology. 267. PMID 7524353  0.56
1993 Shannon VR, Chanez P, Bousquet J, Holtzman MJ. Histochemical evidence for induction of arachidonate 15-lipoxygenase in airway disease American Review of Respiratory Disease. 147: 1024-1028. PMID 8466102  0.56
1993 Shornick LP, Holtzman MJ. A cryptic, microsomal-type arachidonate 12-lipoxygenase is tonically inactivated by oxidation-reduction conditions in cultured epithelial cells Journal of Biological Chemistry. 268: 371-376. PMID 8416945  0.56
1993 Shannon VR, Stenson WF, Holtzman MJ. Induction of epithelial arachidonate 12-lipoxygenase at active sites of inflammatory bowel disease American Journal of Physiology - Gastrointestinal and Liver Physiology. 264. PMID 7679252  0.56
1992 Holtzman MJ. Arachidonic acid metabolism in airway epithelial cells Annual Review of Physiology. 54: 303-329. PMID 1562177  0.56
1992 Holtzman MJ, Look DC. Cell adhesion molecules as targets for unraveling the genetic regulation of airway inflammation American Journal of Respiratory Cell and Molecular Biology. 7: 246-247. PMID 1520488  0.56
1992 Shannon VR, Ramanadham S, Turk J, Holtzman MJ. Selective expression of an arachidonate 12-lipoxygenase by pancreatic islet β-cells American Journal of Physiology - Endocrinology and Metabolism. 263. PMID 1443114  0.56
1992 Holtzman MJ, Turk J, Shornick LP. Identification of a pharmacologically distinct prostaglandin H synthase in cultured epithelial cells Journal of Biological Chemistry. 267: 21438-21445. PMID 1400457  0.56
1992 Look DC, Rapp SR, Keller BT, Holtzman MJ. Selective induction of intercellular adhesion molecule-1 by interferon-γ in human airway epithelial cells American Journal of Physiology - Lung Cellular and Molecular Physiology. 263. PMID 1353306  0.56
1991 Holtzman MJ, Ferdman B, Bohrer A, Turk J. Synthesis of the 1-O-hexadecyl molecular species of platelet-activating factor by airway epithelial and vascular endothelial cells. Biochemical and Biophysical Research Communications. 177: 357-64. PMID 2043121 DOI: 10.1016/0006-291X(91)91991-K  0.56
1991 Holtzman MJ. Arachidonic acid metabolism: Implications of biological chemistry for lung function and disease American Review of Respiratory Disease. 143: 188-203. PMID 1898844  0.56
1991 Shannon VR, Hansbrough JR, Takahashi Y, Ueda N, Yamamoto S, Holtzman MJ. Biochemical and immunohistochemical evidence for selective expression of novel epithelial lipoxygenases Advances in Prostaglandin, Thromboxane, and Leukotriene Research. 21: 37-40. PMID 1825573  0.56
1991 Shannon VR, Crouch EC, Takahashi Y, Ueda N, Yamamoto S, Holtzman MJ. Related expression of arachidonate 12- and 15-lipoxygenases in animal and human lung tissue American Journal of Physiology - Lung Cellular and Molecular Physiology. 261. PMID 1767860  0.56
1990 Hansbrough JR, Takahashi Y, Ueda N, Yamamoto S, Holtzman MJ. Identification of a novel arachidonate 12-lipoxygenase in bovine tracheal epithelial cells distinct from leukocyte and platelet forms of the enzyme Journal of Biological Chemistry. 265: 1771-1776. PMID 2295656  0.56
1990 Pentland AP, Mahoney M, Jacobs SC, Holtzman MJ. Enhanced prostaglandin synthesis after ultraviolet injury is mediated by endogenous histamine stimulation. A mechanism for irradiation erythema. The Journal of Clinical Investigation. 86: 566-74. PMID 1696589 DOI: 10.1172/JCI114746  0.56
1990 Holtzman MJ. Mechanisms of lipid mediator release in airway epithelial cells Immunology and Allergy Clinics of North America. 10: 309-318.  0.56
1989 Holtzman MJ, Pentland A, Baenziger NL, Hansbrough JR. Heterogeneity of cellular expression of arachidonate 15-lipoxygenase: implications for biological activity. Biochimica Et Biophysica Acta. 1003: 204-8. PMID 2730892 DOI: 10.1016/0005-2760(89)90257-9  0.56
1989 Hansbrough JR, Atlas AB, Turk J, Holtzman MJ. Arachidonate 12-lipoxygenase and cyclooxygenase: PGE isomerase are predominant pathways for oxygenation in bovine tracheal epithelial cells. American Journal of Respiratory Cell and Molecular Biology. 1: 237-44. PMID 2516452 DOI: 10.1165/ajrcmb/1.3.237  0.56
1989 Holtzman MJ, Turk J, Pentland A. A regiospecific monooxygenase with novel stereopreference is the major pathway for arachidonic acid oxygenation in isolated epidermal cells. The Journal of Clinical Investigation. 84: 1446-53. PMID 2509517 DOI: 10.1172/JCI114319  0.56
1989 Rosen GD, Birkenmeier TM, Raz A, Holtzman MJ. Identification of a cyclooxygenase-related gene and its potential role in prostaglandin formation. Biochemical and Biophysical Research Communications. 164: 1358-65. PMID 2480117 DOI: 10.1016/0006-291X(89)91819-6  0.56
1988 Holtzman MJ, Hansbrough JR, Rosen GD, Turk J. Uptake, release and novel species-dependent oxygenation of arachidonic acid in human and animal airway epithelial cells. Biochimica Et Biophysica Acta. 963: 401-13. PMID 2848586 DOI: 10.1016/0005-2760(88)90308-6  0.56
1987 Sigal CE, Valone FH, Holtzman MJ, Goetzl EJ. Preferential human eosinophil chemotactic activity of the platelet-activating factor (PAF) 1-0-hexadecyl-2-acetyl-sn-glyceryl-3-phosphocholine (AGEPC) Journal of Clinical Immunology. 7: 179-184. PMID 3571436 DOI: 10.1007/BF00916012  0.56
1987 Bigby TD, Holtzman MJ. Enhanced 5-lipoxygenase activity in lung macrophages compared to monocytes from normal subjects Journal of Immunology. 138: 1546-1550. PMID 3027181  0.56
1987 Holtzman MJ. Species-specificity of lipoxygenase and cyclooxygenase activities expressed in pulmonary airway epithelial cells Advances in Prostaglandin, Thromboxane, and Leukotriene Research. 17: 177-179. PMID 2959043  0.56
1986 Holtzman MJ, Grunberger D, Hunter JA. Phospholipid fatty acid composition of pulmonary airway epithelial cells: potential substrates for oxygenation. Biochimica Et Biophysica Acta. 877: 459-64. PMID 3089291 DOI: 10.1016/0005-2760(86)90212-2  0.56
1986 Holtzman MJ. Lipoxgenation of arachidonic acid in tracheal epithelial cells Clinical Respiratory Physiology. 22: 38.  0.56
1985 Boushey HA, Holtzman MJ. Experimental airway inflammation and hyperreactivity. Searching for cells and mediators American Review of Respiratory Disease. 131: 312-313. PMID 3977169  0.56
1985 Hunter JA, Finkbeiner WE, Nadel JA, Goetzl EJ, Holtzman MJ. Predominant generation of 15-lipoxygenase metabolites of arachidonic acid by epithelial cells from human trachea Proceedings of the National Academy of Sciences of the United States of America. 82: 4633-4637. PMID 3927287 DOI: 10.1073/pnas.82.14.4633  0.56
1985 Fabbri LM, Aizawa H, O'Byrne PM, Bethel RA, Walters EH, Holtzman MJ, Nadel JA. An anti-inflammatory drug (BW755C) inhibits airway hyperresponsiveness induced by ozone in dogs The Journal of Allergy and Clinical Immunology. 76: 162-166. PMID 3926851 DOI: 10.1016/0091-6749(85)90695-5  0.56
1985 Lazarus SC, Gold WM, Goetzl EJ, Holtzman MJ. 15-, 12-, and 5-lipoxygenase products of arachidonic acid differ between two canine mastocytoma cell lines Federation Proceedings. 44.  0.56
1984 Fabbri LM, Aizawa H, Alpert SE, Walters EH, O'Byrne PM, Gold BD, Nadel JA, Holtzman MJ. Airway hyperresponsiveness and changes in cell counts in bronchoalveolar lavage after ozone exposure in dogs American Review of Respiratory Disease. 129: 288-291. PMID 6696327  0.56
1984 O'Byrne PM, Aizawa H, Bethel RA, Chung KF, Nadel JA, Holtzman MJ. Prostaglandin F2α increases responsiveness of pulmonary airways in dogs Prostaglandins. 28: 537-543. PMID 6596652 DOI: 10.1016/0090-6980(84)90242-9  0.56
1984 O'Byrne PM, Walters EH, Aizawa H, Fabbri LM, Holtzman MJ, Nadel JA. Indomethacin inhibits the airway hyperresponsiveness but not the neutrophil influx induced by ozone in dogs American Review of Respiratory Disease. 130: 220-224. PMID 6465676  0.56
1984 O'Byrne PM, Walters EH, Gold BD, Aizawa HA, Fabbri LM, Alpert SE, Nadel JA, Holtzman MJ. Neutrophil depletion inhibits airway hyperresponsiveness induced by ozone exposure American Review of Respiratory Disease. 130: 214-219. PMID 6465675  0.56
1984 Walters EH, O'Byrne PM, Fabbri LM, Graf PD, Holtzman MJ, Nadel JA. Control of neurotransmission by prostaglandins in canine trachealis smooth muscle. Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology. 57: 129-34. PMID 6088448  0.56
1983 Holtzman MJ, Fabbri LM, O'Byrne PM, Gold BD, Aizawa H, Walters EH, Alpert SE, Nadel JA. Importance of airway inflammation for hyperresponsiveness induced by ozone American Review of Respiratory Disease. 127: 686-690. PMID 6859651  0.56
1983 Holtzman MJ, McNamara MP, Sheppard D, Fabbri LM, Hahn HL, Graf PD, Nadel JA. Intravenous versus inhaled atropine for inhibiting bronchoconstrictor responses in dogs. Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology. 54: 134-9. PMID 6826397  0.56
1983 Holtzman MJ, Fabbri LM, Skoogh BE, O'Byrne PM, Walters EH, Aizawa H, Nadel JA. Time course of airway hyperresponsiveness induced by ozone in dogs Journal of Applied Physiology Respiratory Environmental and Exercise Physiology. 55: 1232-1236. PMID 6629955  0.56
1983 Sheppard D, Epstein J, Holtzman MJ, Nadel JA, Boushey HA. Effect of route of atropine delivery on bronchospasm from cold air and methacholine Journal of Applied Physiology Respiratory Environmental and Exercise Physiology. 54: 130-133. PMID 6337982  0.56
1983 Holtzman MJ, Aizawa H, Nadel JA, Goetzl EJ. Selective generation of leukotriene B4 by tracheal epithelial cells from dogs Biochemical and Biophysical Research Communications. 114: 1071-1076. PMID 6311194 DOI: 10.1016/0006-291X(83)90671-X  0.56
1983 Skoogh BE, Nadel JA, Fabbri LM, Sheppard D, Holtzman MJ. Antihistaminic versus anticholinergic effects of atropine on canine trachealis muscle American Review of Respiratory Disease. 128: 603-606. PMID 6137986  0.56
1982 Skoogh BE, Holtzman MJ, Sheller JR, Nadel JA. Barbiturates depress vagal motor pathway to ferret trachea at ganglia Journal of Applied Physiology Respiratory Environmental and Exercise Physiology. 53: 253-257. PMID 7118638  0.56
1982 Holtzman MJ, Hahn HL, Sasaki K, Skoogh BE, Graf PD, Fabbri LM, Nadel JA. Selective effect of general anesthetics on reflex bronchoconstrictor responses in dogs. Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology. 53: 126-33. PMID 7118625  0.56
1982 Sheller JR, Holtzman MJ, Skoogh BE, Nadel JA. Interaction of serotonin with vagal- and ACh-induced bronchoconstriction in canine lungs Journal of Applied Physiology Respiratory Environmental and Exercise Physiology. 52: 964-966. PMID 7085430  0.56
1982 Sheppard D, Epstein J, Holtzman MJ, Nadel JA, Boushey HA. Dose-dependent inhibition of cold air-induced bronchoconstriction by atropine Journal of Applied Physiology Respiratory Environmental and Exercise Physiology. 53: 169-174. PMID 6749773  0.56
1982 Holtzman MJ, McNamara M, Sheppard D. Inhibition of bronchomotor responses to vagal stimulation and acetylcholine inhalation by atropine: Importance of route of administration Federation Proceedings. 41: 6349.  0.56
1981 Holtzman MJ, Nadel JA. Treatment of asthma and bronchoconstriction Rational Drug Therapy. 15. PMID 6819593  0.56
1981 Dimeo MJ, Glenn MG, Holtzman MJ, Sheller JR, Nadel JA, Boushey HA. Threshold concentration of ozone causing an increase in bronchial reactivity in humans and adaptation with repeated exposures American Review of Respiratory Disease. 124: 245-248. PMID 6169298  0.56
1981 Holtzman MJ, Skoogh BE, Hahn H. Effect of general anesthetics on bronchomotor responses Physiologist. 24.  0.56
1981 Sheller JR, Holtzman MJ, Skoogh BE. Effect of serotonin on the airway smooth muscle response to vagal stimulation and to acetylcholine American Review of Respiratory Disease. 123: 198.  0.56
1981 Skoogh BE, Holtzman MJ, Sheller JR, Nadel JA. Differential effect of pentobarbital on the response to parasympathetic ganglion stimulation vs. electrical field stimulation in ferret tracheal rings American Review of Respiratory Disease. 123: 202.  0.56
1980 Boushey HA, Holtzman MJ, Sheller JR, Nadel JA. Bronchial hyperreactivity American Review of Respiratory Disease. 121: 389-413. PMID 6987924  0.56
1980 Holtzman MJ, Sheller JR, Dimeo M, Nadel JA, Boushey HA. Effect of ganglionic blockade on bronchial reactivity in atopic subjects American Review of Respiratory Disease. 122: 17-25. PMID 6105834  0.56
1979 Holtzman MJ, Cunningham JH, Sheller JR, Irsigler GB, Nadel JA, Boushey HA. Effect of ozone on bronchial reactivity in atopic and nonatopic subjects American Review of Respiratory Disease. 120: 1059-1067. PMID 507522  0.56
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