Erol Fikrig - Publications

Affiliations: 
Yale University, New Haven, CT 
Area:
Molecular Biology, Microbiology Biology, Immunology

207 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Hwang J, Jurado KA, Fikrig E. Genetics of War and Truce between Mosquitos and Emerging Viruses. Cell Host & Microbe. 19: 583-7. PMID 27173926 DOI: 10.1016/j.chom.2016.04.009  0.88
2015 Wang P, Zhu S, Yang L, Cui S, Pan W, Jackson R, Zheng Y, Rongvaux A, Sun Q, Yang G, Gao S, Lin R, You F, Flavell R, Fikrig E. Nlrp6 regulates intestinal antiviral innate immunity. Science (New York, N.Y.). PMID 26494172 DOI: 10.1126/science.aab3145  0.88
2015 Walker WE, Kurscheid S, Joshi S, Lopez CA, Goh G, Choi M, Barakat L, Francis J, Fisher A, Kozal M, Zapata H, Shaw A, Lifton R, Sutton RE, Fikrig E. Increased Levels of Macrophage Inflammatory Proteins Result in Resistance to R5-Tropic HIV-1 in a Subset of Elite Controllers. Journal of Virology. 89: 5502-14. PMID 25740989 DOI: 10.1128/JVI.00118-15  0.88
2015 Heisig M, Mattessich S, Rembisz A, Acar A, Shapiro M, Booth CJ, Neelakanta G, Fikrig E. Frostbite protection in mice expressing an antifreeze glycoprotein. Plos One. 10: e0116562. PMID 25714402 DOI: 10.1371/journal.pone.0116562  0.88
2015 Qian F, Goel G, Meng H, Wang X, You F, Devine L, Raddassi K, Garcia MN, Murray KO, Bolen CR, Gaujoux R, Shen-Orr SS, Hafler D, Fikrig E, Xavier R, et al. Systems immunology reveals markers of susceptibility to West Nile virus infection. Clinical and Vaccine Immunology : Cvi. 22: 6-16. PMID 25355795 DOI: 10.1128/CVI.00508-14  0.88
2015 Narasimhan S, Fikrig E. Tick microbiome: The force within Trends in Parasitology. 31: 315-323. DOI: 10.1016/j.pt.2015.03.010  0.88
2014 Heisig M, Abraham NM, Liu L, Neelakanta G, Mattessich S, Sultana H, Shang Z, Ansari JM, Killiam C, Walker W, Cooley L, Flavell RA, Agaisse H, Fikrig E. Antivirulence properties of an antifreeze protein. Cell Reports. 9: 417-24. PMID 25373896 DOI: 10.1016/j.celrep.2014.09.034  0.88
2014 Li MW, Wang J, Zhao YO, Fikrig E. Innexin AGAP001476 is critical for mediating anti-Plasmodium responses in Anopheles mosquitoes. The Journal of Biological Chemistry. 289: 24885-97. PMID 25035430 DOI: 10.1074/jbc.M114.554519  0.88
2014 Krause PJ, Narasimhan S, Wormser GP, Barbour AG, Platonov AE, Brancato J, Lepore T, Dardick K, Mamula M, Rollend L, Steeves TK, Diuk-Wasser M, Usmani-Brown S, Williamson P, Sarksyan DS, ... Fikrig E, et al. Borrelia miyamotoi sensu lato seroreactivity and seroprevalence in the northeastern United States. Emerging Infectious Diseases. 20: 1183-90. PMID 24960072 DOI: 10.3201/eid2007.131587  0.88
2014 Seidman D, Ojogun N, Walker NJ, Mastronunzio J, Kahlon A, Hebert KS, Karandashova S, Miller DP, Tegels BK, Marconi RT, Fikrig E, Borjesson DL, Carlyon JA. Anaplasma phagocytophilum surface protein AipA mediates invasion of mammalian host cells. Cellular Microbiology. 16: 1133-45. PMID 24612118 DOI: 10.1111/cmi.12286  0.88
2014 Qian F, Thakar J, Yuan X, Nolan M, Murray KO, Lee WT, Wong SJ, Meng H, Fikrig E, Kleinstein SH, Montgomery RR. Immune markers associated with host susceptibility to infection with West Nile virus. Viral Immunology. 27: 39-47. PMID 24605787 DOI: 10.1089/vim.2013.0074  0.88
2014 Narasimhan S, Rajeevan N, Liu L, Zhao YO, Heisig J, Pan J, Eppler-Epstein R, Deponte K, Fish D, Fikrig E. Gut microbiota of the tick vector Ixodes scapularis modulate colonization of the Lyme disease spirochete. Cell Host & Microbe. 15: 58-71. PMID 24439898 DOI: 10.1016/j.chom.2013.12.001  0.88
2014 Conway MJ, Watson AM, Colpitts TM, Dragovic SM, Li Z, Wang P, Feitosa F, Shepherd DT, Ryman KD, Klimstra WB, Anderson JF, Fikrig E. Mosquito saliva serine protease enhances dissemination of dengue virus into the mammalian host. Journal of Virology. 88: 164-75. PMID 24131723 DOI: 10.1128/JVI.02235-13  0.88
2013 You F, Wang P, Yang L, Yang G, Zhao YO, Qian F, Walker W, Sutton R, Montgomery R, Lin R, Iwasaki A, Fikrig E. ELF4 is critical for induction of type I interferon and the host antiviral response. Nature Immunology. 14: 1237-46. PMID 24185615 DOI: 10.1038/ni.2756  0.88
2013 Bobenchik AM, Witola WH, Augagneur Y, Nic Lochlainn L, Garg A, Pachikara N, Choi JY, Zhao YO, Usmani-Brown S, Lee A, Adjalley SH, Samanta S, Fidock DA, Voelker DR, Fikrig E, et al. Plasmodium falciparum phosphoethanolamine methyltransferase is essential for malaria transmission. Proceedings of the National Academy of Sciences of the United States of America. 110: 18262-7. PMID 24145416 DOI: 10.1073/pnas.1313965110  0.88
2013 Hovius JW, de Wever B, Sohne M, Brouwer MC, Coumou J, Wagemakers A, Oei A, Knol H, Narasimhan S, Hodiamont CJ, Jahfari S, Pals ST, Horlings HM, Fikrig E, Sprong H, et al. A case of meningoencephalitis by the relapsing fever spirochaete Borrelia miyamotoi in Europe. Lancet. 382: 658. PMID 23953389 DOI: 10.1016/S0140-6736(13)61644-X  0.88
2013 Silver AC, Dunne DW, Zeiss CJ, Bockenstedt LK, Radolf JD, Salazar JC, Fikrig E. MyD88 deficiency markedly worsens tissue inflammation and bacterial clearance in mice infected with Treponema pallidum, the agent of syphilis. Plos One. 8: e71388. PMID 23940747 DOI: 10.1371/journal.pone.0071388  0.88
2013 Qian F, Chung L, Zheng W, Bruno V, Alexander RP, Wang Z, Wang X, Kurscheid S, Zhao H, Fikrig E, Gerstein M, Snyder M, Montgomery RR. Identification of genes critical for resistance to infection by West Nile virus using RNA-Seq analysis. Viruses. 5: 1664-81. PMID 23881275 DOI: 10.3390/v5071664  0.88
2013 Narasimhan S, Perez O, Mootien S, DePonte K, Koski RA, Fikrig E, Ledizet M. Characterization of Ixophilin, a thrombin inhibitor from the gut of Ixodes scapularis. Plos One. 8: e68012. PMID 23874485 DOI: 10.1371/journal.pone.0068012  0.88
2013 Schuijt TJ, Bakhtiari K, Daffre S, Deponte K, Wielders SJ, Marquart JA, Hovius JW, van der Poll T, Fikrig E, Bunce MW, Camire RM, Nicolaes GA, Meijers JC, van 't Veer C. Factor Xa activation of factor V is of paramount importance in initiating the coagulation system: lessons from a tick salivary protein. Circulation. 128: 254-66. PMID 23817575 DOI: 10.1161/CIRCULATIONAHA.113.003191  0.88
2013 Wang J, Zhang Y, Zhao YO, Li MW, Zhang L, Dragovic S, Abraham NM, Fikrig E. Anopheles gambiae circumsporozoite protein-binding protein facilitates plasmodium infection of mosquito salivary glands. The Journal of Infectious Diseases. 208: 1161-9. PMID 23801601 DOI: 10.1093/infdis/jit284  0.88
2013 Yang X, Hegde S, Shroder DY, Smith AA, Promnares K, Neelakanta G, Anderson JF, Fikrig E, Pal U. The lipoprotein La7 contributes to Borrelia burgdorferi persistence in ticks and their transmission to naïve hosts. Microbes and Infection / Institut Pasteur. 15: 729-37. PMID 23774694 DOI: 10.1016/j.micinf.2013.06.001  0.88
2013 Magnarelli LA, Williams SC, Norris SJ, Fikrig E. Serum antibodies to Borrelia burgdorferi, Anaplasma phagocytophilum, and Babesia microti in recaptured white-footed mice. Journal of Wildlife Diseases. 49: 294-302. PMID 23568904 DOI: 10.7589/2012-06-172  0.88
2013 Wang P, Yang L, Cheng G, Yang G, Xu Z, You F, Sun Q, Lin R, Fikrig E, Sutton RE. UBXN1 interferes with Rig-I-like receptor-mediated antiviral immune response by targeting MAVS. Cell Reports. 3: 1057-70. PMID 23545497 DOI: 10.1016/j.celrep.2013.02.027  0.88
2013 Krause PJ, Narasimhan S, Wormser GP, Rollend L, Fikrig E, Lepore T, Barbour A, Fish D. Human Borrelia miyamotoi infection in the United States. The New England Journal of Medicine. 368: 291-3. PMID 23323920 DOI: 10.1056/NEJMc1215469  0.88
2013 Qian F, Bolen CR, Jing C, Wang X, Zheng W, Zhao H, Fikrig E, Bruce RD, Kleinstein SH, Montgomery RR. Impaired toll-like receptor 3-mediated immune responses from macrophages of patients chronically infected with hepatitis C virus. Clinical and Vaccine Immunology : Cvi. 20: 146-55. PMID 23220997 DOI: 10.1128/CVI.00530-12  0.88
2013 Ullmann AJ, Dolan MC, Sackal CA, Fikrig E, Piesman J, Zeidner NS. Immunization with adenoviral-vectored tick salivary gland proteins (SALPs) in a murine model of Lyme borreliosis Ticks and Tick-Borne Diseases. 4: 160-163. PMID 23141105 DOI: 10.1016/j.ttbdis.2012.08.006  0.88
2013 Kahlon A, Ojogun N, Ragland SA, Seidman D, Troese MJ, Ottens AK, Mastronunzio JE, Truchan HK, Walker NJ, Borjesson DL, Fikrig E, Carlyon JA. Anaplasma phagocytophilum Asp14 is an invasin that interacts with mammalian host cells via its C terminus to facilitate infection Infection and Immunity. 81: 65-79. PMID 23071137 DOI: 10.1128/IAI.00932-12  0.88
2012 Colpitts TM, Conway MJ, Montgomery RR, Fikrig E. West Nile Virus: biology, transmission, and human infection. Clinical Microbiology Reviews. 25: 635-48. PMID 23034323 DOI: 10.1128/CMR.00045-12  0.88
2012 Arjona A, Silver AC, Walker WE, Fikrig E. Immunity's fourth dimension: approaching the circadian-immune connection. Trends in Immunology. 33: 607-12. PMID 23000010 DOI: 10.1016/j.it.2012.08.007  0.88
2012 Wang P, Bai F, Zenewicz LA, Dai J, Gate D, Cheng G, Yang L, Qian F, Yuan X, Montgomery RR, Flavell RA, Town T, Fikrig E. IL-22 signaling contributes to West Nile encephalitis pathogenesis. Plos One. 7: e44153. PMID 22952908 DOI: 10.1371/journal.pone.0044153  0.88
2012 Ojogun N, Kahlon A, Ragland SA, Troese MJ, Mastronunzio JE, Walker NJ, Viebrock L, Thomas RJ, Borjesson DL, Fikrig E, Carlyon JA. Anaplasma phagocytophilum outer membrane protein A interacts with sialylated glycoproteins to promote infection of mammalian host cells. Infection and Immunity. 80: 3748-60. PMID 22907813 DOI: 10.1128/IAI.00654-12  0.88
2012 Sultana H, Neelakanta G, Foellmer HG, Montgomery RR, Anderson JF, Koski RA, Medzhitov RM, Fikrig E. Semaphorin 7A contributes to West Nile virus pathogenesis through TGF-β1/Smad6 signaling. Journal of Immunology (Baltimore, Md. : 1950). 189: 3150-8. PMID 22896629 DOI: 10.4049/jimmunol.1201140  0.88
2012 Liu L, Dai J, Zhao YO, Narasimhan S, Yang Y, Zhang L, Fikrig E. Ixodes scapularis JAK-STAT pathway regulates tick antimicrobial peptides, thereby controlling the agent of human granulocytic anaplasmosis. The Journal of Infectious Diseases. 206: 1233-41. PMID 22859824 DOI: 10.1093/infdis/jis484  0.88
2012 Zhao YO, Kurscheid S, Zhang Y, Liu L, Zhang L, Loeliger K, Fikrig E. Enhanced survival of Plasmodium-infected mosquitoes during starvation. Plos One. 7: e40556. PMID 22808193 DOI: 10.1371/journal.pone.0040556  0.88
2012 Sukumaran B, Ogura Y, Pedra JH, Kobayashi KS, Flavell RA, Fikrig E. Receptor interacting protein-2 contributes to host defense against Anaplasma phagocytophilum infection. Fems Immunology and Medical Microbiology. 66: 211-9. PMID 22747758 DOI: 10.1111/j.1574-695X.2012.01001.x  0.88
2012 Ouyang Z, Narasimhan S, Neelakanta G, Kumar M, Pal U, Fikrig E, Norgard MV. Activation of the RpoN-RpoS regulatory pathway during the enzootic life cycle of Borrelia burgdorferi. Bmc Microbiology. 12: 44. PMID 22443136 DOI: 10.1186/1471-2180-12-44  0.88
2012 da Silva Voorham JM, Rodenhuis-Zybert IA, Ayala Nuñez NV, Colpitts TM, van der Ende-Metselaar H, Fikrig E, Diamond MS, Wilschut J, Smit JM. Antibodies against the envelope glycoprotein promote infectivity of immature dengue virus serotype 2. Plos One. 7: e29957. PMID 22431958 DOI: 10.1371/journal.pone.0029957  0.88
2012 Neelakanta G, Hudson AM, Sultana H, Cooley L, Fikrig E. Expression of Ixodes scapularis antifreeze glycoprotein enhances cold tolerance in Drosophila melanogaster. Plos One. 7: e33447. PMID 22428051 DOI: 10.1371/journal.pone.0033447  0.88
2012 Mastronunzio JE, Kurscheid S, Fikrig E. Postgenomic analyses reveal development of infectious Anaplasma phagocytophilum during transmission from ticks to mice. Journal of Bacteriology. 194: 2238-47. PMID 22389475 DOI: 10.1128/JB.06791-11  0.88
2012 Silver AC, Arjona A, Walker WE, Fikrig E. The circadian clock controls toll-like receptor 9-mediated innate and adaptive immunity. Immunity. 36: 251-61. PMID 22342842 DOI: 10.1016/j.immuni.2011.12.017  0.88
2012 Magnarelli LA, Norris SJ, Fikrig E. Serum antibodies to whole-cell and recombinant antigens of Borrelia burgdorferi in cottontail rabbits. Journal of Wildlife Diseases. 48: 12-20. PMID 22247369 DOI: 10.7589/0090-3558-48.1.12  0.88
2012 Anderson JF, Main AJ, Cheng G, Ferrandino FJ, Fikrig E. Horizontal and vertical transmission of West Nile virus genotype NY99 by Culex salinarius and genotypes NY99 and WN02 by Culex tarsalis. The American Journal of Tropical Medicine and Hygiene. 86: 134-9. PMID 22232464 DOI: 10.4269/ajtmh.2012.11-0473  0.88
2012 Qian F, Wang X, Zhang L, Chen S, Piecychna M, Allore H, Bockenstedt L, Malawista S, Bucala R, Shaw AC, Fikrig E, Montgomery RR. Age-associated elevation in TLR5 leads to increased inflammatory responses in the elderly. Aging Cell. 11: 104-10. PMID 22023165 DOI: 10.1111/j.1474-9726.2011.00759.x  0.88
2012 Silver AC, Arjona A, Hughes ME, Nitabach MN, Fikrig E. Circadian expression of clock genes in mouse macrophages, dendritic cells, and B cells. Brain, Behavior, and Immunity. 26: 407-13. PMID 22019350 DOI: 10.1016/j.bbi.2011.10.001  0.88
2012 Biswas S, Chang H, Sarkis PTN, Fikrig E, Zhu Q, Marasco WA. Humoral immune responses in humanized BLT mice immunized with West Nile virus and HIV-1 envelope proteins are largely mediated via human CD5 + B cells Immunology. 136: 361-361. DOI: 10.1111/j.1365-2567.2012.03586.x  0.88
2011 Biswas S, Chang H, Sarkis PT, Fikrig E, Zhu Q, Marasco WA. Humoral immune responses in humanized BLT mice immunized with West Nile virus and HIV-1 envelope proteins are largely mediated via human CD5+ B cells. Immunology. 134: 419-33. PMID 22044090 DOI: 10.1111/j.1365-2567.2011.03501.x  0.88
2011 Liu L, Narasimhan S, Dai J, Zhang L, Cheng G, Fikrig E. Ixodes scapularis salivary gland protein P11 facilitates migration of Anaplasma phagocytophilum from the tick gut to salivary glands. Embo Reports. 12: 1196-203. PMID 21921936 DOI: 10.1038/embor.2011.177  0.88
2011 Colpitts TM, Barthel S, Wang P, Fikrig E. Dengue virus capsid protein binds core histones and inhibits nucleosome formation in human liver cells. Plos One. 6: e24365. PMID 21909430 DOI: 10.1371/journal.pone.0024365  0.88
2011 Colpitts TM, Cox J, Vanlandingham DL, Feitosa FM, Cheng G, Kurscheid S, Wang P, Krishnan MN, Higgs S, Fikrig E. Alterations in the Aedes aegypti transcriptome during infection with West Nile, dengue and yellow fever viruses. Plos Pathogens. 7: e1002189. PMID 21909258 DOI: 10.1371/journal.ppat.1002189  0.88
2011 Schuijt TJ, Coumou J, Narasimhan S, Dai J, Deponte K, Wouters D, Brouwer M, Oei A, Roelofs JJ, van Dam AP, van der Poll T, Van't Veer C, Hovius JW, Fikrig E. A tick mannose-binding lectin inhibitor interferes with the vertebrate complement cascade to enhance transmission of the lyme disease agent. Cell Host & Microbe. 10: 136-46. PMID 21843870 DOI: 10.1016/j.chom.2011.06.010  0.88
2011 Cheng G, Liu L, Wang P, Zhang Y, Zhao YO, Colpitts TM, Feitosa F, Anderson JF, Fikrig E. An in vivo transfection approach elucidates a role for Aedes aegypti thioester-containing proteins in flaviviral infection. Plos One. 6: e22786. PMID 21818390 DOI: 10.1371/journal.pone.0022786  0.88
2011 Arjona A, Wang P, Montgomery RR, Fikrig E. Innate immune control of West Nile virus infection. Cellular Microbiology. 13: 1648-58. PMID 21790942 DOI: 10.1111/j.1462-5822.2011.01649.x  0.88
2011 van Burgel ND, Balmus NCM, Fikrig E, van Dam AP. Infectivity of Borrelia burgdorferi sensu lato is unaltered in C3-deficient mice Ticks and Tick-Borne Diseases. 2: 20-26. PMID 21771533 DOI: 10.1016/j.ttbdis.2010.10.003  0.88
2011 Colpitts TM, Cox J, Nguyen A, Feitosa F, Krishnan MN, Fikrig E. Use of a tandem affinity purification assay to detect interactions between West Nile and dengue viral proteins and proteins of the mosquito vector. Virology. 417: 179-87. PMID 21700306 DOI: 10.1016/j.virol.2011.06.002  0.88
2011 Colpitts TM, Rodenhuis-Zybert I, Moesker B, Wang P, Fikrig E, Smit JM. prM-antibody renders immature West Nile virus infectious in vivo. The Journal of General Virology. 92: 2281-5. PMID 21697345 DOI: 10.1099/vir.0.031427-0  0.88
2011 Zhang L, Zhang Y, Adusumilli S, Liu L, Narasimhan S, Dai J, Zhao YO, Fikrig E. Molecular interactions that enable movement of the Lyme disease agent from the tick gut into the hemolymph. Plos Pathogens. 7: e1002079. PMID 21695244 DOI: 10.1371/journal.ppat.1002079  0.88
2011 Qian F, Wang X, Zhang L, Lin A, Zhao H, Fikrig E, Montgomery RR. Impaired interferon signaling in dendritic cells from older donors infected in vitro with West Nile virus. The Journal of Infectious Diseases. 203: 1415-24. PMID 21398396 DOI: 10.1093/infdis/jir048  0.88
2011 Schuijt TJ, Narasimhan S, Daffre S, DePonte K, Hovius JW, Van't Veer C, van der Poll T, Bakhtiari K, Meijers JC, Boder ET, van Dam AP, Fikrig E. Identification and characterization of Ixodes scapularis antigens that elicit tick immunity using yeast surface display. Plos One. 6: e15926. PMID 21246036 DOI: 10.1371/journal.pone.0015926  0.88
2011 Sukumaran B, Mastronunzio JE, Narasimhan S, Fankhauser S, Uchil PD, Levy R, Graham M, Colpitts TM, Lesser CF, Fikrig E. Anaplasma phagocytophilum AptA modulates Erk1/2 signalling. Cellular Microbiology. 13: 47-61. PMID 20716207 DOI: 10.1111/j.1462-5822.2010.01516.x  0.88
2011 Schuijt TJ, Hovius JW, van der Poll T, van Dam AP, Fikrig E. Lyme borreliosis vaccination: The facts, the challenge, the future Trends in Parasitology. 27: 40-47. PMID 20594913 DOI: 10.1016/j.pt.2010.06.006  0.88
2011 Sultana H, Neelakanta G, Kantor FS, Malawista SE, Fish D, Montgomery RR, Fikrig E. Correction: Anaplasma phagocytophilum induces actin phosphorylation to selectively regulate gene transcription in Ixodes scapularis ticks Journal of Experimental Medicine. 208: 1737. DOI: 10.1084/jem.201002762088c  0.88
2010 Dai J, Narasimhan S, Zhang L, Liu L, Wang P, Fikrig E. Tick histamine release factor is critical for Ixodes scapularis engorgement and transmission of the lyme disease agent. Plos Pathogens. 6: e1001205. PMID 21124826 DOI: 10.1371/journal.ppat.1001205  0.88
2010 Bai F, Kong KF, Dai J, Qian F, Zhang L, Brown CR, Fikrig E, Montgomery RR. A paradoxical role for neutrophils in the pathogenesis of West Nile virus. The Journal of Infectious Diseases. 202: 1804-12. PMID 21050124 DOI: 10.1086/657416  0.88
2010 Wang P, Arjona A, Zhang Y, Sultana H, Dai J, Yang L, LeBlanc PM, Doiron K, Saleh M, Fikrig E. Caspase-12 controls West Nile virus infection via the viral RNA receptor RIG-I. Nature Immunology. 11: 912-9. PMID 20818395 DOI: 10.1038/ni.1933  0.88
2010 Cheng G, Cox J, Wang P, Krishnan MN, Dai J, Qian F, Anderson JF, Fikrig E. A C-type lectin collaborates with a CD45 phosphatase homolog to facilitate West Nile virus infection of mosquitoes. Cell. 142: 714-25. PMID 20797779 DOI: 10.1016/j.cell.2010.07.038  0.88
2010 Neelakanta G, Sultana H, Fish D, Anderson JF, Fikrig E. Anaplasma phagocytophilum induces Ixodes scapularis ticks to express an antifreeze glycoprotein gene that enhances their survival in the cold. The Journal of Clinical Investigation. 120: 3179-90. PMID 20739755 DOI: 10.1172/JCI42868  0.88
2010 Magnarelli LA, Williams SC, Fikrig E. Seasonal prevalence of serum antibodies to whole cell and recombinant antigens of Borrelia burgdorferi and Anaplasma phagocytophilum in white-tailed deer in Connecticut. Journal of Wildlife Diseases. 46: 781-90. PMID 20688684 DOI: 10.7589/0090-3558-46.3.781  0.88
2010 Demento SL, Bonafé N, Cui W, Kaech SM, Caplan MJ, Fikrig E, Ledizet M, Fahmy TM. TLR9-targeted biodegradable nanoparticles as immunization vectors protect against West Nile encephalitis. Journal of Immunology (Baltimore, Md. : 1950). 185: 2989-97. PMID 20660705 DOI: 10.4049/jimmunol.1000768  0.88
2010 Sultana H, Neelakanta G, Kantor FS, Malawista SE, Fish D, Montgomery RR, Fikrig E. Anaplasma phagocytophilum induces actin phosphorylation to selectively regulate gene transcription in Ixodes scapularis ticks. The Journal of Experimental Medicine. 207: 1727-43. PMID 20660616 DOI: 10.1084/jem.20100276  0.88
2010 Dunne DW, Shaw A, Bockenstedt LK, Allore HG, Chen S, Malawista SE, Leng L, Mizue Y, Piecychna M, Zhang L, Towle V, Bucala R, Montgomery RR, Fikrig E. Increased TLR4 expression and downstream cytokine production in immunosuppressed adults compared to non-immunosuppressed adults. Plos One. 5: e11343. PMID 20596538 DOI: 10.1371/journal.pone.0011343  0.88
2010 Pedra JH, Narasimhan S, Rendić D, DePonte K, Bell-Sakyi L, Wilson IB, Fikrig E. Fucosylation enhances colonization of ticks by Anaplasma phagocytophilum. Cellular Microbiology. 12: 1222-34. PMID 20331643 DOI: 10.1111/j.1462-5822.2010.01464.x  0.88
2010 Panda A, Qian F, Mohanty S, van Duin D, Newman FK, Zhang L, Chen S, Towle V, Belshe RB, Fikrig E, Allore HG, Montgomery RR, Shaw AC. Age-associated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response. Journal of Immunology (Baltimore, Md. : 1950). 184: 2518-27. PMID 20100933 DOI: 10.4049/jimmunol.0901022  0.88
2010 Adusumilli S, Booth CJ, Anguita J, Fikrig E. Passage through Ixodes scapularis ticks enhances the virulence of a weakly pathogenic isolate of Borrelia burgdorferi. Infection and Immunity. 78: 138-44. PMID 19822652 DOI: 10.1128/IAI.00470-09  0.88
2009 Brass AL, Huang IC, Benita Y, John SP, Krishnan MN, Feeley EM, Ryan BJ, Weyer JL, van der Weyden L, Fikrig E, Adams DJ, Xavier RJ, Farzan M, Elledge SJ. The IFITM Proteins Mediate Cellular Resistance to Influenza A H1N1 Virus, West Nile Virus, and Dengue Virus Cell. 139: 1243-1254. PMID 20064371 DOI: 10.1016/j.cell.2009.12.017  0.88
2009 Dai J, Wang P, Adusumilli S, Booth CJ, Narasimhan S, Anguita J, Fikrig E. Antibodies against a tick protein, Salp15, protect mice from the Lyme disease agent. Cell Host & Microbe. 6: 482-92. PMID 19917502 DOI: 10.1016/j.chom.2009.10.006  0.88
2009 Bai F, Town T, Qian F, Wang P, Kamanaka M, Connolly TM, Gate D, Montgomery RR, Flavell RA, Fikrig E. IL-10 signaling blockade controls murine West Nile virus infection. Plos Pathogens. 5: e1000610. PMID 19816558 DOI: 10.1371/journal.ppat.1000610  0.88
2009 Fikrig E, Narasimhan S, Neelakanta G, Pal U, Chen M, Flavell R. Toll-like receptors 1 and 2 heterodimers alter Borrelia burgdorferi gene expression in mice and ticks. The Journal of Infectious Diseases. 200: 1331-40. PMID 19754309 DOI: 10.1086/605950  0.88
2009 Panda A, Arjona A, Sapey E, Bai F, Fikrig E, Montgomery RR, Lord JM, Shaw AC. Human innate immunosenescence: causes and consequences for immunity in old age. Trends in Immunology. 30: 325-33. PMID 19541535 DOI: 10.1016/j.it.2009.05.004  0.88
2009 Sultana H, Foellmer HG, Neelakanta G, Oliphant T, Engle M, Ledizet M, Krishnan MN, Bonafé N, Anthony KG, Marasco WA, Kaplan P, Montgomery RR, Diamond MS, Koski RA, Fikrig E. Fusion loop peptide of the West Nile virus envelope protein is essential for pathogenesis and is recognized by a therapeutic cross-reactive human monoclonal antibody. Journal of Immunology (Baltimore, Md. : 1950). 183: 650-60. PMID 19535627 DOI: 10.4049/jimmunol.0900093  0.88
2009 Hovius JW, Bijlsma MF, van der Windt GJ, Wiersinga WJ, Boukens BJ, Coumou J, Oei A, de Beer R, de Vos AF, van 't Veer C, van Dam AP, Wang P, Fikrig E, Levi MM, Roelofs JJ, et al. The urokinase receptor (uPAR) facilitates clearance of Borrelia burgdorferi. Plos Pathogens. 5: e1000447. PMID 19461880 DOI: 10.1371/journal.ppat.1000447  0.88
2009 Demento SL, Eisenbarth SC, Foellmer HG, Platt C, Caplan MJ, Mark Saltzman W, Mellman I, Ledizet M, Fikrig E, Flavell RA, Fahmy TM. Inflammasome-activating nanoparticles as modular systems for optimizing vaccine efficacy. Vaccine. 27: 3013-21. PMID 19428913 DOI: 10.1016/j.vaccine.2009.03.034  0.88
2009 Guo X, Booth CJ, Paley MA, Wang X, DePonte K, Fikrig E, Narasimhan S, Montgomery RR. Inhibition of neutrophil function by two tick salivary proteins. Infection and Immunity. 77: 2320-9. PMID 19332533 DOI: 10.1128/IAI.01507-08  0.88
2009 Town T, Bai F, Wang T, Kaplan AT, Qian F, Montgomery RR, Anderson JF, Flavell RA, Fikrig E. Toll-like receptor 7 mitigates lethal West Nile encephalitis via interleukin 23-dependent immune cell infiltration and homing. Immunity. 30: 242-53. PMID 19200759 DOI: 10.1016/j.immuni.2008.11.012  0.88
2009 Anthony KG, Bai F, Krishnan MN, Fikrig E, Koski RA. Effective siRNA targeting of the 3' untranslated region of the West Nile virus genome. Antiviral Research. 82: 166-8. PMID 19135091 DOI: 10.1016/j.antiviral.2008.12.007  0.88
2009 Bonafé N, Rininger JA, Chubet RG, Foellmer HG, Fader S, Anderson JF, Bushmich SL, Anthony K, Ledizet M, Fikrig E, Koski RA, Kaplan P. A recombinant West Nile virus envelope protein vaccine candidate produced in Spodoptera frugiperda expresSF+ cells. Vaccine. 27: 213-22. PMID 18996430 DOI: 10.1016/j.vaccine.2008.10.046  0.88
2008 Thomas V, Samanta S, Fikrig E. Anaplasma phagocytophilum increases cathepsin L activity, thereby globally influencing neutrophil function. Infection and Immunity. 76: 4905-12. PMID 18765732 DOI: 10.1128/IAI.00851-08  0.88
2008 Hovius JW, Schuijt TJ, de Groot KA, Roelofs JJ, Oei GA, Marquart JA, de Beer R, van 't Veer C, van der Poll T, Ramamoorthi N, Fikrig E, van Dam AP. Preferential protection of Borrelia burgdorferi sensu stricto by a Salp15 homologue in Ixodes ricinus saliva. The Journal of Infectious Diseases. 198: 1189-97. PMID 18752445 DOI: 10.1086/591917  0.88
2008 Yang X, Izadi H, Coleman AS, Wang P, Ma Y, Fikrig E, Anguita J, Pal U. Borrelia burgdorferi lipoprotein BmpA activates pro-inflammatory responses in human synovial cells through a protein moiety. Microbes and Infection / Institut Pasteur. 10: 1300-8. PMID 18725314 DOI: 10.1016/j.micinf.2008.07.029  0.88
2008 Krishnan MN, Ng A, Sukumaran B, Gilfoy FD, Uchil PD, Sultana H, Brass AL, Adametz R, Tsui M, Qian F, Montgomery RR, Lev S, Mason PW, Koski RA, Elledge SJ, ... ... Fikrig E, et al. RNA interference screen for human genes associated with West Nile virus infection. Nature. 455: 242-5. PMID 18690214 DOI: 10.1038/nature07207  0.88
2008 Wang S, Welte T, McGargill M, Town T, Thompson J, Anderson JF, Flavell RA, Fikrig E, Hedrick SM, Wang T. Drak2 contributes to West Nile virus entry into the brain and lethal encephalitis. Journal of Immunology (Baltimore, Md. : 1950). 181: 2084-91. PMID 18641347  0.88
2008 Wang P, Dai J, Bai F, Kong KF, Wong SJ, Montgomery RR, Madri JA, Fikrig E. Matrix metalloproteinase 9 facilitates West Nile virus entry into the brain. Journal of Virology. 82: 8978-85. PMID 18632868 DOI: 10.1128/JVI.00314-08  0.88
2008 Anderson JF, Main AJ, Delroux K, Fikrig E. Extrinsic incubation periods for horizontal and vertical transmission of West Nile virus by Culex pipiens pipiens (Diptera: Culicidae). Journal of Medical Entomology. 45: 445-51. PMID 18533438 DOI: 10.1603/0022-2585(2008)45[445:EIPFHA]2.0.CO;2  0.88
2008 Kong KF, Delroux K, Wang X, Qian F, Arjona A, Malawista SE, Fikrig E, Montgomery RR. Dysregulation of TLR3 impairs the innate immune response to West Nile virus in the elderly. Journal of Virology. 82: 7613-23. PMID 18508883 DOI: 10.1128/JVI.00618-08  0.88
2008 Schuijt TJ, Hovius JW, van Burgel ND, Ramamoorthi N, Fikrig E, van Dam AP. The tick salivary protein Salp15 inhibits the killing of serum-sensitive Borrelia burgdorferi sensu lato isolates. Infection and Immunity. 76: 2888-94. PMID 18426890 DOI: 10.1128/IAI.00232-08  0.88
2008 Kong KF, Wang X, Anderson JF, Fikrig E, Montgomery RR. West nile virus attenuates activation of primary human macrophages. Viral Immunology. 21: 78-82. PMID 18355125 DOI: 10.1089/vim.2007.0072  0.88
2008 Hovius JW, de Jong MA, den Dunnen J, Litjens M, Fikrig E, van der Poll T, Gringhuis SI, Geijtenbeek TB. Salp15 binding to DC-SIGN inhibits cytokine expression by impairing both nucleosome remodeling and mRNA stabilization. Plos Pathogens. 4: e31. PMID 18282094 DOI: 10.1371/journal.ppat.0040031  0.88
2008 Hovius JW, Levi M, Fikrig E. Salivating for knowledge: potential pharmacological agents in tick saliva. Plos Medicine. 5: e43. PMID 18271624 DOI: 10.1371/journal.pmed.0050043  0.88
2008 Dai J, Wang P, Bai F, Town T, Fikrig E. Icam-1 participates in the entry of west nile virus into the central nervous system. Journal of Virology. 82: 4164-8. PMID 18256150 DOI: 10.1128/JVI.02621-07  0.88
2008 Pal U, Dai J, Li X, Neelakanta G, Luo P, Kumar M, Wang P, Yang X, Anderson JF, Fikrig E. A differential role for BB0365 in the persistence of Borrelia burgdorferi in mice and ticks. The Journal of Infectious Diseases. 197: 148-55. PMID 18171298 DOI: 10.1086/523764  0.88
2008 Pal U, Wang P, Bao F, Yang X, Samanta S, Schoen R, Wormser GP, Schwartz I, Fikrig E. Borrelia burgdorferi basic membrane proteins A and B participate in the genesis of Lyme arthritis. The Journal of Experimental Medicine. 205: 133-41. PMID 18166585 DOI: 10.1084/jem.20070962  0.88
2008 Pedra JH, Mattner J, Tao J, Kerfoot SM, Davis RJ, Flavell RA, Askenase PW, Yin Z, Fikrig E. c-Jun NH2-terminal kinase 2 inhibits gamma interferon production during Anaplasma phagocytophilum infection. Infection and Immunity. 76: 308-16. PMID 17998313 DOI: 10.1128/IAI.00599-07  0.88
2008 Anguita J, Olson CM, Fikrig E. Immune responses to spirochetes Clinical Immunology. 411-420. DOI: 10.1016/B978-0-323-04404-2.10026-0  0.88
2007 Ledizet M, Kar K, Foellmer HG, Bonafé N, Anthony KG, Gould LH, Bushmich SL, Fikrig E, Koski RA. Antibodies targeting linear determinants of the envelope protein protect mice against West Nile virus. The Journal of Infectious Diseases. 196: 1741-8. PMID 18190253 DOI: 10.1086/523654  0.88
2007 Arjona A, Ledizet M, Anthony K, Bonafé N, Modis Y, Town T, Fikrig E. West Nile virus envelope protein inhibits dsRNA-induced innate immune responses. Journal of Immunology (Baltimore, Md. : 1950). 179: 8403-9. PMID 18056386  0.88
2007 Narasimhan S, Sukumaran B, Bozdogan U, Thomas V, Liang X, DePonte K, Marcantonio N, Koski RA, Anderson JF, Kantor F, Fikrig E. A tick antioxidant facilitates the Lyme disease agent's successful migration from the mammalian host to the arthropod vector. Cell Host & Microbe. 2: 7-18. PMID 18005713 DOI: 10.1016/j.chom.2007.06.001  0.88
2007 Arjona A, Foellmer HG, Town T, Leng L, McDonald C, Wang T, Wong SJ, Montgomery RR, Fikrig E, Bucala R. Abrogation of macrophage migration inhibitory factor decreases West Nile virus lethality by limiting viral neuroinvasion. The Journal of Clinical Investigation. 117: 3059-66. PMID 17909632 DOI: 10.1172/JCI32218  0.88
2007 Hovius JWR, Ramamoorthi N, Van't Veer C, De Groot KA, Nijhof AM, Jongejan F, Van Dam AP, Fikrig E. Identification of Salp15 homologues in Ixodes ricinus ticks Vector-Borne and Zoonotic Diseases. 7: 296-303. PMID 17896872 DOI: 10.1089/vbz.2006.0624  0.88
2007 Pedra JH, Sutterwala FS, Sukumaran B, Ogura Y, Qian F, Montgomery RR, Flavell RA, Fikrig E. ASC/PYCARD and caspase-1 regulate the IL-18/IFN-gamma axis during Anaplasma phagocytophilum infection. Journal of Immunology (Baltimore, Md. : 1950). 179: 4783-91. PMID 17878377 DOI: 10.4049/jimmunol.179.7.4783  0.88
2007 Hovius JWR, van Dam AP, Fikrig E. Tick-host-pathogen interactions in Lyme borreliosis Trends in Parasitology. 23: 434-438. PMID 17656156 DOI: 10.1016/j.pt.2007.07.001  0.88
2007 Tyson K, Elkins C, Patterson H, Fikrig E, De Silva A. Biochemical and functional characterization of Salp20, an Ixodes scapularis tick salivary protein that inhibits the complement pathway Insect Molecular Biology. 16: 469-479. PMID 17651236 DOI: 10.1111/j.1365-2583.2007.00742.x  0.88
2007 Li X, Neelakanta G, Liu X, Beck DS, Kantor FS, Fish D, Anderson JF, Fikrig E. Role of outer surface protein D in the Borrelia burgdorferi life cycle. Infection and Immunity. 75: 4237-44. PMID 17620358 DOI: 10.1128/IAI.00632-07  0.88
2007 Pedra JH, Tao J, Sutterwala FS, Sukumaran B, Berliner N, Bockenstedt LK, Flavell RA, Yin Z, Fikrig E. IL-12/23p40-dependent clearance of Anaplasma phagocytophilum in the murine model of human anaplasmosis. Fems Immunology and Medical Microbiology. 50: 401-10. PMID 17521390 DOI: 10.1111/j.1574-695X.2007.00270.x  0.88
2007 Narasimhan S, Deponte K, Marcantonio N, Liang X, Royce TE, Nelson KF, Booth CJ, Koski B, Anderson JF, Kantor F, Fikrig E. Immunity against Ixodes scapularis salivary proteins expressed within 24 hours of attachment thwarts tick feeding and impairs Borrelia transmission. Plos One. 2: e451. PMID 17505544 DOI: 10.1371/journal.pone.0000451  0.88
2007 McDonald WF, Huleatt JW, Foellmer HG, Hewitt D, Tang J, Desai P, Price A, Jacobs A, Takahashi VN, Huang Y, Nakaar V, Alexopoulou L, Fikrig E, Powell TJ. A West Nile virus recombinant protein vaccine that coactivates innate and adaptive immunity. The Journal of Infectious Diseases. 195: 1607-17. PMID 17471430 DOI: 10.1086/517613  0.88
2007 Neelakanta G, Li X, Pal U, Liu X, Beck DS, DePonte K, Fish D, Kantor FS, Fikrig E. Outer surface protein B is critical for Borrelia burgdorferi adherence and survival within Ixodes ticks. Plos Pathogens. 3: e33. PMID 17352535 DOI: 10.1371/journal.ppat.0030033  0.88
2007 Thomas V, Fikrig E. Anaplasma phagocytophilum specifically induces tyrosine phosphorylation of ROCK1 during infection. Cellular Microbiology. 9: 1730-7. PMID 17346310 DOI: 10.1111/j.1462-5822.2007.00908.x  0.88
2007 Hovius JW, Li X, Ramamoorthi N, van Dam AP, Barthold SW, van der Poll T, Speelman P, Fikrig E. Coinfection with Borrelia burgdorferi sensu stricto and Borrelia garinii alters the course of murine Lyme borreliosis. Fems Immunology and Medical Microbiology. 49: 224-34. PMID 17328756 DOI: 10.1111/j.1574-695X.2006.00177.x  0.88
2007 Krishnan MN, Sukumaran B, Pal U, Agaisse H, Murray JL, Hodge TW, Fikrig E. Rab 5 is required for the cellular entry of dengue and West Nile viruses. Journal of Virology. 81: 4881-5. PMID 17301152 DOI: 10.1128/JVI.02210-06  0.88
2007 van Duin D, Mohanty S, Thomas V, Ginter S, Montgomery RR, Fikrig E, Allore HG, Medzhitov R, Shaw AC. Age-associated defect in human TLR-1/2 function. Journal of Immunology (Baltimore, Md. : 1950). 178: 970-5. PMID 17202359  0.88
2007 Li X, Pal U, Ramamoorthi N, Liu X, Desrosiers DC, Eggers CH, Anderson JF, Radolf JD, Fikrig E. The Lyme disease agent Borrelia burgdorferi requires BB0690, a Dps homologue, to persist within ticks. Molecular Microbiology. 63: 694-710. PMID 17181780 DOI: 10.1111/j.1365-2958.2006.05550.x  0.88
2007 Bai F, Town T, Pradhan D, Cox J, Ashish, Ledizet M, Anderson JF, Flavell RA, Krueger JK, Koski RA, Fikrig E. Antiviral peptides targeting the west nile virus envelope protein. Journal of Virology. 81: 2047-55. PMID 17151121 DOI: 10.1128/JVI.01840-06  0.88
2006 Magnarelli LA, Stafford KC, Ijdo JW, Fikrig E. Antibodies to whole-cell or recombinant antigens of Borrelia burgdorferi, Anaplasma phagocytophilum, and Babesia microti in white-footed mice Journal of Wildlife Diseases. 42: 732-738. PMID 17255439  0.88
2006 Garg R, Juncadella IJ, Ramamoorthi N, Ashish, Ananthanarayanan SK, Thomas V, Rincón M, Krueger JK, Fikrig E, Yengo CM, Anguita J. Cutting edge: CD4 is the receptor for the tick saliva immunosuppressor, Salp15. Journal of Immunology (Baltimore, Md. : 1950). 177: 6579-83. PMID 17082567  0.88
2006 Pedra JH, Narasimhan S, Deponte K, Marcantonio N, Kantor FS, Fikrig E. Disruption of the salivary protein 14 in Ixodes scapularis nymphs and impact on pathogen acquisition. The American Journal of Tropical Medicine and Hygiene. 75: 677-82. PMID 17038693  0.88
2006 Kanai R, Kar K, Anthony K, Gould LH, Ledizet M, Fikrig E, Marasco WA, Koski RA, Modis Y. Crystal structure of west nile virus envelope glycoprotein reveals viral surface epitopes. Journal of Virology. 80: 11000-8. PMID 16943291 DOI: 10.1128/JVI.01735-06  0.88
2006 Wang T, Gao Y, Scully E, Davis CT, Anderson JF, Welte T, Ledizet M, Koski R, Madri JA, Barrett A, Yin Z, Craft J, Fikrig E. Gamma delta T cells facilitate adaptive immunity against West Nile virus infection in mice. Journal of Immunology (Baltimore, Md. : 1950). 177: 1825-32. PMID 16849493 DOI: 10.4049/JIMMUNOL.177.3.1825  0.88
2006 Sukumaran B, Narasimhan S, Anderson JF, DePonte K, Marcantonio N, Krishnan MN, Fish D, Telford SR, Kantor FS, Fikrig E. An Ixodes scapularis protein required for survival of Anaplasma phagocytophilum in tick salivary glands. The Journal of Experimental Medicine. 203: 1507-17. PMID 16717118 DOI: 10.1084/jem.20060208  0.88
2006 Li X, Liu X, Beck DS, Kantor FS, Fikrig E. Borrelia burgdorferi lacking BBK32, a fibronectin-binding protein, retains full pathogenicity Infection and Immunity. 74: 3305-3313. PMID 16714558 DOI: 10.1128/IAI.02035-05  0.88
2006 Shrestha B, Wang T, Samuel MA, Whitby K, Craft J, Fikrig E, Diamond MS. Gamma interferon plays a crucial early antiviral role in protection against West Nile virus infection. Journal of Virology. 80: 5338-48. PMID 16699014 DOI: 10.1128/JVI.00274-06  0.88
2006 Fikrig E, Narasimhan S. Borrelia burgdorferi-Traveling incognito? Microbes and Infection. 8: 1390-1399. PMID 16698304 DOI: 10.1016/j.micinf.2005.12.022  0.88
2006 Carlyon JA, Fikrig E. Mechanisms of evasion of neutrophil killing by Anaplasma phagocytophilum. Current Opinion in Hematology. 13: 28-33. PMID 16319684  0.88
2005 Magnarelli LA, Bushmich SL, Ijdo JW, Fikrig E. Seroprevalence of antibodies against Borrelia burgdorferi and Anaplasma phagocytophilum in cats American Journal of Veterinary Research. 66: 1895-1899. PMID 16334946 DOI: 10.2460/ajvr.2005.66.1895  0.88
2005 Sukumaran B, Carlyon JA, Cai JL, Berliner N, Fikrig E. Early transcriptional response of human neutrophils to Anaplasma phagocytophilum infection. Infection and Immunity. 73: 8089-99. PMID 16299303 DOI: 10.1128/IAI.73.12.8089-8099.2005  0.88
2005 Gould LH, Sui J, Foellmer H, Oliphant T, Wang T, Ledizet M, Murakami A, Noonan K, Lambeth C, Kar K, Anderson JF, de Silva AM, Diamond MS, Koski RA, Marasco WA, ... Fikrig E, et al. Protective and therapeutic capacity of human single-chain Fv-Fc fusion proteins against West Nile virus. Journal of Virology. 79: 14606-13. PMID 16282460 DOI: 10.1128/JVI.79.23.14606-14613.2005  0.88
2005 Carlyon JA, Ryan D, Archer K, Fikrig E. Effects of Anaplasma phagocytophilum on host cell ferritin mRNA and protein levels. Infection and Immunity. 73: 7629-36. PMID 16239567 DOI: 10.1128/IAI.73.11.7629-7636.2005  0.88
2005 Xu O, Seemanapalli SV, Lomax L, McShan K, Li X, Fikrig E, Liang FT. Association of linear plasmid 28-1 with an arthritic phenotype of Borrelia burgdorferi Infection and Immunity. 73: 7208-7215. PMID 16239515 DOI: 10.1128/IAI.73.11.7208-7215.2005  0.88
2005 Ramamoorthi N, Narasimhan S, Pal U, Bao F, Yang XF, Fish D, Anguita J, Norgard MV, Kantor FS, Anderson JF, Koski RA, Fikrig E. The Lyme disease agent exploits a tick protein to infect the mammalian host. Nature. 436: 573-7. PMID 16049492 DOI: 10.1038/nature03812  0.88
2005 Pedra JH, Sukumaran B, Carlyon JA, Berliner N, Fikrig E. Modulation of NB4 promyelocytic leukemic cell machinery by Anaplasma phagocytophilum. Genomics. 86: 365-77. PMID 16005178 DOI: 10.1016/j.ygeno.2005.05.008  0.88
2005 Magnarelli L, Fikrig E. Detection of antibodies to Borrelia burgdorferi in naturally infected horses in the USA by enzyme-linked immunosorbent assay using whole-cell and recombinant antigens Research in Veterinary Science. 79: 99-103. PMID 15924926 DOI: 10.1016/j.rvsc.2004.11.009  0.88
2005 Ledizet M, Kar K, Foellmer HG, Wang T, Bushmich SL, Anderson JF, Fikrig E, Koski RA. A recombinant envelope protein vaccine against West Nile virus. Vaccine. 23: 3915-24. PMID 15917113 DOI: 10.1016/j.vaccine.2005.03.006  0.88
2005 Bai F, Wang T, Pal U, Bao F, Gould LH, Fikrig E. Use of RNA interference to prevent lethal murine west nile virus infection. The Journal of Infectious Diseases. 191: 1148-54. PMID 15747251 DOI: 10.1086/428507  0.88
2005 Thomas V, Samanta S, Wu C, Berliner N, Fikrig E. Anaplasma phagocytophilum modulates gp91phox gene expression through altered interferon regulatory factor 1 and PU.1 levels and binding of CCAAT displacement protein Infection and Immunity. 73: 208-218. PMID 15618156 DOI: 10.1128/IAI.73.1.208-218.2005  0.88
2004 Wang T, Town T, Alexopoulou L, Anderson JF, Fikrig E, Flavell RA. Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis. Nature Medicine. 10: 1366-73. PMID 15558055 DOI: 10.1038/nm1140  0.88
2004 Pal U, Li X, Wang T, Montgomery RR, Ramamoorthi N, Desilva AM, Bao F, Yang X, Pypaert M, Pradhan D, Kantor FS, Telford S, Anderson JF, Fikrig E. TROSPA, an Ixodes scapularis receptor for Borrelia burgdorferi. Cell. 119: 457-68. PMID 15537536 DOI: 10.1016/j.cell.2004.10.027  0.88
2004 Wang T, Akkoyunlu M, Banerjee R, Fikrig E. Interferon-γ deficiency reveals that 129Sv mice are inherently more susceptible to Anaplasma phagocytophilum than C57BL/6 mice Fems Immunology and Medical Microbiology. 42: 299-305. PMID 15477043 DOI: 10.1016/j.femsim.2004.06.001  0.88
2004 Liang FT, Yan J, Mbow ML, Sviat SL, Gilmore RD, Mamula M, Fikrig E. Borrelia burgdorferi changes its surface antigenic expression in response to host immune responses. Infection and Immunity. 72: 5759-67. PMID 15385475 DOI: 10.1128/IAI.72.10.5759-5767.2004  0.88
2004 Magnarelli LA, Bushmich SL, Sherman BA, Fikrig E. A comparison of serologic tests for the detection of serum antibodies to whole-cell and recombinant Borrelia burgdorferi antigens in cattle Canadian Veterinary Journal. 45: 667-673. PMID 15368740  0.88
2004 Magnarelli LA, IJdo JW, Ramakrishnan U, Henderson DW, Stafford KC, Fikrig E. Use of recombinant antigens of Borrelia burgdorferi and Anaplasma phagocytophilum in enzyme-linked immunosorbent assays to detect antibodies in white-tailed deer. Journal of Wildlife Diseases. 40: 249-58. PMID 15362824 DOI: 10.7589/0090-3558-40.2.249  0.88
2004 Scorpio DG, Akkoyunlu M, Fikrig E, Dumler JS. CXCR2 blockade influences Anaplasma phagocytophilum propagation but not histopathology in the mouse model of human granulocytic anaplasmosis Clinical and Diagnostic Laboratory Immunology. 11: 963-968. PMID 15358660 DOI: 10.1128/CDLI.11.5.963-968.2004  0.88
2004 Liang FT, Brown EL, Wang T, Iozzo RV, Fikrig E. Protective niche for Borrelia burgdorferi to evade humoral immunity. The American Journal of Pathology. 165: 977-85. PMID 15331421 DOI: 10.1016/S0002-9440(10)63359-7  0.88
2004 Carlyon JA, Abdel-Latif D, Pypaert M, Lacy P, Fikrig E. Anaplasma phagocytophilum utilizes multiple host evasion mechanisms to thwart NADPH oxidase-mediated killing during neutrophil infection. Infection and Immunity. 72: 4772-83. PMID 15271939 DOI: 10.1128/IAI.72.8.4772-4783.2004  0.88
2004 Wang T, Fikrig E. Immunity to West Nile virus Current Opinion in Immunology. 16: 519-523. PMID 15245749 DOI: 10.1016/j.coi.2004.05.008  0.88
2004 Liang FT, Caimano MJ, Radolf JD, Fikrig E. Borrelia burgdorferi outer surface protein (osp) B expression independent of ospA. Microbial Pathogenesis. 37: 35-40. PMID 15194158 DOI: 10.1016/j.micpath.2004.02.007  0.88
2004 Gould LH, Fikrig E. West Nile virus: a growing concern? The Journal of Clinical Investigation. 113: 1102-7. PMID 15085186 DOI: 10.1172/JCI21623  0.88
2004 Fikrig E, Coyle PK, Schutzer SE, Chen M, Deng Z, Flavell RA. Preferential Presence of Decorin-Binding Protein B (BBA25) and BBA50 Antibodies in Cerebrospinal Fluid of Patients with Neurologic Lyme Disease Journal of Clinical Microbiology. 42: 1243-1246. PMID 15004083 DOI: 10.1128/JCM.42.3.1243-1246.2004  0.88
2004 Yang XF, Pal U, Alani SM, Fikrig E, Norgard MV. Essential role for OspA/B in the life cycle of the Lyme disease spirochete. The Journal of Experimental Medicine. 199: 641-8. PMID 14981112 DOI: 10.1084/jem.20031960  0.88
2004 Fikrig E, Pal U, Chen M, Anderson JF, Flavell RA. OspB antibody prevents Borrelia burgdorferi colonization of Ixodes scapularis. Infection and Immunity. 72: 1755-9. PMID 14977984 DOI: 10.1128/IAI.72.3.1755-1759.2004  0.88
2004 Narasimhan S, Montgomery RR, DePonte K, Tschudi C, Marcantonio N, Anderson JF, Sauer JR, Cappello M, Kantor FS, Fikrig E. Disruption of Ixodes scapularis anticoagulation by using RNA interference. Proceedings of the National Academy of Sciences of the United States of America. 101: 1141-6. PMID 14745044 DOI: 10.1073/pnas.0307669100  0.88
2004 Pal U, Yang X, Chen M, Bockenstedt LK, Anderson JF, Flavell RA, Norgard MV, Fikrig E. OspC facilitates Borrelia burgdorferi invasion of Ixodes scapularis salivary glands. The Journal of Clinical Investigation. 113: 220-30. PMID 14722614 DOI: 10.1172/JCI19894  0.88
2004 Wong SJ, Demarest VL, Boyle RH, Wang T, Ledizet M, Kar K, Kramer LD, Fikrig E, Koski RA. Detection of human anti-flavivirus antibodies with a west nile virus recombinant antigen microsphere immunoassay. Journal of Clinical Microbiology. 42: 65-72. PMID 14715733 DOI: 10.1128/JCM.42.1.65-72.2004  0.88
2003 Narasimhan S, Caimano MJ, Liang FT, Santiago F, Laskowski M, Philipp MT, Pachner AR, Radolf JD, Fikrig E, Camaino MJ. Borrelia burgdorferi transcriptome in the central nervous system of non-human primates. Proceedings of the National Academy of Sciences of the United States of America. 100: 15953-8. PMID 14671329 DOI: 10.1073/pnas.2432412100  0.88
2003 Anguita J, Hedrick MN, Fikrig E. Adaptation of Borrelia burgdorferi in the tick and the mammalian host. Fems Microbiology Reviews. 27: 493-504. PMID 14550942 DOI: 10.1016/S0168-6445(03)00036-6  0.88
2003 Carlyon JA, Fikrig E. Invasion and survival strategies of Anaplasma phagocytophilum. Cellular Microbiology. 5: 743-54. PMID 14531890 DOI: 10.1046/j.1462-5822.2003.00323.x  0.88
2003 Wong SJ, Boyle RH, Demarest VL, Woodmansee AN, Kramer LD, Li H, Drebot M, Koski RA, Fikrig E, Martin DA, Shi PY. Immunoassay targeting nonstructural protein 5 to differentiate West Nile virus infection from dengue and St. Louis encephalitis virus infections and from flavivirus vaccination. Journal of Clinical Microbiology. 41: 4217-23. PMID 12958248 DOI: 10.1128/JCM.41.9.4217-4223.2003  0.88
2003 Wang T, Scully E, Yin Z, Kim JH, Wang S, Yan J, Mamula M, Anderson JF, Craft J, Fikrig E. IFN-gamma-producing gamma delta T cells help control murine West Nile virus infection. Journal of Immunology (Baltimore, Md. : 1950). 171: 2524-31. PMID 12928402 DOI: 10.4049/JIMMUNOL.171.5.2524  0.88
2003 Carlyon JA, Akkoyunlu M, Xia L, Yago T, Wang T, Cummings RD, McEver RP, Fikrig E. Murine neutrophils require alpha1,3-fucosylation but not PSGL-1 for productive infection with Anaplasma phagocytophilum. Blood. 102: 3387-95. PMID 12869507 DOI: 10.1182/blood-2003-02-0621  0.88
2003 Yago T, Leppänen A, Carlyon JA, Akkoyunlu M, Karmakar S, Fikrig E, Cummings RD, McEver RP. Structurally distinct requirements for binding of P-selectin glycoprotein ligand-1 and sialyl Lewis x to Anaplasma phagocytophilum and P-selectin. The Journal of Biological Chemistry. 278: 37987-97. PMID 12847092 DOI: 10.1074/jbc.M305778200  0.88
2003 Pal U, Fikrig E. Adaptation of Borrelia burgdorferi in the vector and vertebrate host. Microbes and Infection / Institut Pasteur. 5: 659-66. PMID 12787742 DOI: 10.1016/S1286-4579(03)00097-2  0.88
2003 Schoen RT, Deshefy-Longhi T, Van-Hoecke C, Buscarino C, Fikrig E. An open-label, nonrandomized, single-center, prospective extension, clinical trial of booster dose schedules to assess the safety profile and immunogenicity of recombinant outer-surface protein A (OspA) Lyme disease vaccine Clinical Therapeutics. 25: 210-224. PMID 12637121 DOI: 10.1016/S0149-2918(03)90027-0  0.88
2003 Welte T, Zhang SS, Wang T, Zhang Z, Hesslein DG, Yin Z, Kano A, Iwamoto Y, Li E, Craft JE, Bothwell AL, Fikrig E, Koni PA, Flavell RA, Fu XY. STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity. Proceedings of the National Academy of Sciences of the United States of America. 100: 1879-84. PMID 12571365 DOI: 10.1073/pnas.0237137100  0.88
2002 Thomas V, Fikrig E. The Lyme disease vaccine takes its toll Vector Borne and Zoonotic Diseases (Larchmont, N.Y.). 2: 217-222. PMID 12804162  0.88
2002 Wang T, Magnarelli LA, Anderson JF, Gould LH, Bushmich SL, Wong SJ, Fikrig E. A recombinant envelope protein-based enzyme-linked immunosorbent assay for West Nile virus serodiagnosis. Vector Borne and Zoonotic Diseases (Larchmont, N.Y.). 2: 105-9. PMID 12653304 DOI: 10.1089/153036602321131904  0.88
2002 Carlyon JA, Chan WT, Galán J, Roos D, Fikrig E. Repression of rac2 mRNA expression by Anaplasma phagocytophila is essential to the inhibition of superoxide production and bacterial proliferation. Journal of Immunology (Baltimore, Md. : 1950). 169: 7009-18. PMID 12471136  0.88
2002 Anguita J, Samanta S, Ananthanarayanan SK, Revilla B, Geba GP, Barthold SW, Fikrig E. Cyclooxygenase 2 activity modulates the severity of murine Lyme arthritis. Fems Immunology and Medical Microbiology. 34: 187-91. PMID 12423770 DOI: 10.1016/S0928-8244(02)00376-0  0.88
2002 Narasimhan S, Koski RA, Beaulieu B, Anderson JF, Ramamoorthi N, Kantor F, Cappello M, Fikrig E. A novel family of anticoagulants from the saliva of Ixodes scapularis Insect Molecular Biology. 11: 641-650. PMID 12421422 DOI: 10.1046/j.1365-2583.2002.00375.x  0.88
2002 Ijdo JW, Wu C, Telford SR, Fikrig E. Differential expression of the p44 gene family in the agent of human granulocytic ehrlichiosis Infection and Immunity. 70: 5295-5298. PMID 12183586 DOI: 10.1128/IAI.70.9.5295-5298.2002  0.88
2002 Magnarelli LA, Lawrenz M, Norris SJ, Fikrig E. Comparative reactivity of human sera to recombinant VlsE and other Borrelia burgdorferi antigens in class-specific enzyme-linked immunosorbent assays for Lyme borreliosis. Journal of Medical Microbiology. 51: 649-55. PMID 12171295 DOI: 10.1099/0022-1317-51-8-649  0.88
2002 Wang T, Malawista SE, Pal U, Grey M, Meek J, Akkoyunlu M, Thomas V, Fikrig E. Superoxide anion production during Anaplasma phagocytophila infection. The Journal of Infectious Diseases. 186: 274-80. PMID 12134266 DOI: 10.1086/341451  0.88
2002 Anguita J, Ramamoorthi N, Hovius JWR, Das S, Thomas V, Persinski R, Conze D, Askenase PW, Rincón M, Kantor FS, Fikrig E. Salp15, an Ixodes scapularis salivary protein, inhibits CD4+ T cell activation Immunity. 16: 849-859. PMID 12121666 DOI: 10.1016/S1074-7613(02)00325-4  0.88
2002 Liang FT, Kenneth Nelson F, Fikrig E. Molecular adaptation of Borrelia burgdorferi in the murine host Journal of Experimental Medicine. 196: 275-280. PMID 12119353 DOI: 10.1084/jem.20020770  0.88
2002 Alexopoulou L, Thomas V, Schnare M, Lobet Y, Anguita J, Schoen RT, Medzhitov R, Fikrig E, Flavell RA. Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice. Nature Medicine. 8: 878-84. PMID 12091878 DOI: 10.1038/nm732  0.88
2002 Anguita J, Barthold SW, Persinski R, Hedrick MN, Huy CA, Davis RJ, Flavell RA, Fikrig E. Murine Lyme arthritis development mediated by p38 mitogen-activated protein kinase activity. Journal of Immunology (Baltimore, Md. : 1950). 168: 6352-7. PMID 12055252 DOI: 10.4049/jimmunol.168.12.6352  0.88
2002 Liang FT, Nelson FK, Fikrig E. DNA microarray assessment of putative Borrelia burgdorferi lipoprotein genes Infection and Immunity. 70: 3300-3303. PMID 12011030 DOI: 10.1128/IAI.70.6.3300-3303.2002  0.88
2002 Narasimhan S, Santiago F, Koski RA, Brei B, Anderson JF, Fish D, Fikrig E. Examination of the Borrelia burgdorferi transcriptome in Ixodes scapularis during feeding. Journal of Bacteriology. 184: 3122-5. PMID 12003955 DOI: 10.1128/JB.184.11.3122-3125.2002  0.88
2002 Magnarelli LA, Ijdo JW, Sherman BA, Bushmich SL, Levy SA, Fikrig E. Antibodies to granulocytic ehrlichiae in cattle from Connecticut Journal of Medical Microbiology. 51: 326-331. PMID 11926738  0.88
2001 Tsao J, Barbour AG, Luke CJ, Fikrig E, Fish D. OspA immunization decreases transmission of Borrelia burgdorferi spirochetes from infected Peromyscus leucopus mice to larval Ixodes scapularis ticks Vector Borne Zoonotic Dis. 1: 65-74. PMID 12653137  0.88
2001 Wang T, Anderson JF, Magnarelli LA, Bushmich S, Wong S, Koski RA, Fikrig E. West Nile virus envelope protein role in diagnosis and immunity Annals of the New York Academy of Sciences. 951: 325-327. PMID 11797789  0.88
2001 Wang T, Anderson JF, Magnarelli LA, Wong SJ, Koski RA, Fikrig E. Immunization of mice against west nile virus with recombinant envelope protein Journal of Immunology. 167: 5273-5277. PMID 11673542  0.88
2001 Magnarelli LA, Levy SA, Ijdo JW, Wu C, Padula SJ, Fikrig E. Reactivity of dog sera to whole-cell or recombinant antigens of Borrelia burgdorferi by ELISA and immunoblot analysis Journal of Medical Microbiology. 50: 889-895. PMID 11599738  0.88
2001 Das S, Banerjee G, DePonte K, Marcantonio N, Kantor FS, Fikrig E. Salp25D, an Ixodes scapularis antioxidant, is 1 of 14 immunodominant antigens in engorged tick salivary glands Journal of Infectious Diseases. 184: 1056-1064. PMID 11574922 DOI: 10.1086/323351  0.88
2001 Magnarelli L, IJdo J, Wu C, Fikrig E. Recombinant protein-44-based class-specific enzyme-linked immunosorbent assays for serologic diagnosis of human granulocytic ehrlichiosis European Journal of Clinical Microbiology and Infectious Diseases. 20: 482-485. PMID 11561804  0.88
2001 Pal U, Montgomery RR, Lusitani D, Voet P, Weynants V, Malawista SE, Lobet Y, Fikrig E. Inhibition of Borrelia burgdorferi-tick interactions in vivo by outer surface protein A antibody. Journal of Immunology (Baltimore, Md. : 1950). 166: 7398-403. PMID 11390491 DOI: 10.4049/JIMMUNOL.166.12.7398  0.88
2000 Diehl S, Anguita J, Hoffmeyer A, Zapton T, Ihle JN, Fikrig E, Rincón M. Inhibition of Th1 differentiation by IL-6 is mediated by SOCS1. Immunity. 13: 805-15. PMID 11163196 DOI: 10.1016/S1074-7613(00)00078-9  0.88
2000 Das S, Marcantonio N, Deponte K, Telford SR, Anderson JF, Kantor FS, Fikrig E. SALP16, a gene induced in Ixodes scapularis salivary glands during tick feeding American Journal of Tropical Medicine and Hygiene. 62: 99-105. PMID 10761732 DOI: 10.4269/ajtmh.2000.62.99  0.88
2000 IJdo JW, Meek JI, Cartter ML, Magnarelli LA, Wu C, Tenuta SW, Fikrig E, Ryder RW. The emergence of another tickborne infection in the 12-town area around Lyme, Connecticut: human granulocytic ehrlichiosis. The Journal of Infectious Diseases. 181: 1388-93. PMID 10751139 DOI: 10.1086/315389  0.88
2000 Anguita J, Samanta S, Revilla B, Suk K, Das S, Barthold SW, Fikrig E. Borrelia burgdorferi gene expression in vivo and spirochete pathogenicity Infection and Immunity. 68: 1222-1230. PMID 10678930 DOI: 10.1128/IAI.68.3.1222-1230.2000  0.88
1998 Magnarelli LA, Ijdo JW, Dumler JS, Heimer R, Fikrig E. Reactivity of human sera to different strains of granulocytic ehrlichiae in immunodiagnostic assays Journal of Infectious Diseases. 178: 1835-1838. PMID 9815246 DOI: 10.1086/314516  0.88
1998 Nazario S, Das S, De Silva AM, Deponte K, Marcantonio N, Anderson JF, Fish D, Fikrig E, Kantor FS. Prevention of Borrelia burgdorferi transmission in guinea pigs by tick immunity American Journal of Tropical Medicine and Hygiene. 58: 780-785. PMID 9660463 DOI: 10.4269/ajtmh.1998.58.780  0.88
1998 Das S, Deponte K, Marcantonio NL, Ijdo JW, Hodzic E, Katavolos P, Barthold SW, Telford SR, Kantor FS, Fikrig E. Granulocytic ehrlichiosis in tick-immune guinea pigs Infection and Immunity. 66: 1803-1805. PMID 9529119 DOI: 10.1128/iai.66.4.1803-1805.1998  0.88
1997 Das S, Barthold SW, Giles SS, Montgomery RR, Telford SR, Fikrig E. Temporal pattern of Borrelia burgdorferi p21 expression in ticks and the mammalian host Journal of Clinical Investigation. 99: 987-995. PMID 9062357 DOI: 10.1172/JCI119264  0.88
1996 Das S, Shraga D, Cannon C, Lam TT, Feng S, Brunet LR, Telford SR, Barthold SW, Flavell RA, Fikrig E. Characterization of a 30-kDa Borrelia burgdorferi substrate-binding protein homologue Research in Microbiology. 147: 739-751. PMID 9296108 DOI: 10.1016/S0923-2508(97)85121-2  0.88
1996 Feng S, Das S, Barthold SW, Fikrig E. Characterization of two genes, p11 and p5, on the Borrelia burgdorferi 49-kilo base linear plasmid Biochimica Et Biophysica Acta - Gene Structure and Expression. 1307: 270-272. PMID 8688460 DOI: 10.1016/0167-4781(96)00076-0  0.88
1995 Suk K, Das S, Sun W, Jwang B, Barthold SW, Flavell RA, Fikrig E. Borrelia burgdorferi genes selectively expressed in the infected host Proceedings of the National Academy of Sciences of the United States of America. 92: 4269-4273. PMID 7753795 DOI: 10.1073/pnas.92.10.4269  0.88
1995 Schoen RT, Meurice F, Brunet CM, Cretella S, Krause DS, Craft JE, Fikrig E. Safety and immunogenicity of an outer surface protein A vaccine in subjects with previous Lyme disease. The Journal of Infectious Diseases. 172: 1324-9. PMID 7594671 DOI: 10.1093/infdis/172.5.1324  0.88
1994 McMillen MA, Cunningham ME, Schoen R, Fikrig E. Gout in patients with systemic lupus erythematosus. British Journal of Rheumatology. 33: 595-6. PMID 8205413 DOI: 10.1093/rheumatology/33.6.595  0.88
1989 Fikrig E, Worthington MT, Lefkowitz LB. Septic shock and acute respiratory distress syndrome after salpingitis caused by Streptococcus pyogenes group A Southern Medical Journal. 82: 634-635. PMID 2655106 DOI: 10.1097/00007611-198905000-00024  0.88
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