| Year |
Citation |
Score |
| 2023 |
Pal P, Alley JR, Townsend CA. Examining Heterodimerization by Aryl C-N Coupling in Dynemicin Biosynthesis. Acs Chemical Biology. PMID 36696117 DOI: 10.1021/acschembio.2c00709 |
0.808 |
|
| 2022 |
Li F, Lin Z, Torres JP, Hill EA, Li D, Townsend CA, Schmidt EW. Sea Urchin Polyketide Synthase SpPks1 Produces the Naphthalene Precursor to Echinoderm Pigments. Journal of the American Chemical Society. 144: 9363-9371. PMID 35588530 DOI: 10.1021/jacs.2c01416 |
0.721 |
|
| 2020 |
Townsend CA, Cohen DR. C-N Coupled Metabolites Yield Insights into Dynemicin A Biosynthesis. Chembiochem : a European Journal of Chemical Biology. PMID 32198800 DOI: 10.1002/Cbic.202000177 |
0.368 |
|
| 2019 |
Sinner EK, Lichstrahl MS, Li R, Marous DR, Townsend CA. Methylations in complex carbapenem biosynthesis are catalyzed by a single cobalamin-dependent radical S-adenosylmethionine enzyme. Chemical Communications (Cambridge, England). PMID 31774078 DOI: 10.1039/C9Cc07197K |
0.387 |
|
| 2019 |
Patel KD, d'Andrea FB, Gaudelli NM, Buller AR, Townsend CA, Gulick AM. Structure of a bound peptide phosphonate reveals the mechanism of nocardicin bifunctional thioesterase epimerase-hydrolase half-reactions. Nature Communications. 10: 3868. PMID 31455765 DOI: 10.1038/S41467-019-11740-6 |
0.724 |
|
| 2019 |
d'Andrea FB, Townsend CA. Late-Stage Conversion of Diphenylphosphonate to Fluorophosphonate Probes for the Investigation of Serine Hydrolases. Cell Chemical Biology. PMID 30982751 DOI: 10.1016/J.Chembiol.2019.02.020 |
0.431 |
|
| 2018 |
Storm PA, Pal P, Huitt-Roehl CR, Townsend CA. Exploring fungal polyketide C-methylation through combinatorial domain swaps. Acs Chemical Biology. PMID 30350943 DOI: 10.1021/Acschembio.8B00429 |
0.341 |
|
| 2018 |
Herbst DA, Townsend CA, Maier T. The architectures of iterative type I PKS and FAS. Natural Product Reports. PMID 30137093 DOI: 10.1039/C8Np00039E |
0.41 |
|
| 2018 |
Long D, Townsend CA. Mechanism of integrated β-lactam formation by a non-ribosomal peptide synthetase during antibiotic synthesis. Biochemistry. PMID 29701951 DOI: 10.1021/Acs.Biochem.8B00411 |
0.399 |
|
| 2018 |
Saraiva RG, Huitt-Roehl CR, Tripathi A, Cheng YQ, Bosch J, Townsend CA, Dimopoulos G. Chromobacterium spp. mediate their anti-Plasmodium activity through secretion of the histone deacetylase inhibitor romidepsin. Scientific Reports. 8: 6176. PMID 29670144 DOI: 10.1038/S41598-018-24296-0 |
0.306 |
|
| 2018 |
Herbst DA, Huitt-Roehl CR, Jakob RP, Kravetz JM, Storm PA, Alley JR, Townsend CA, Maier T. The structural organization of substrate loading in iterative polyketide synthases. Nature Chemical Biology. PMID 29610486 DOI: 10.1038/s41589-018-0026-3 |
0.774 |
|
| 2018 |
Cohen DR, Townsend CA. Characterization of an Anthracene Intermediate in Dynemicin Biosynthesis. Angewandte Chemie (International Ed. in English). PMID 29512267 DOI: 10.1002/Anie.201802036 |
0.383 |
|
| 2018 |
Cohen DR, Townsend CA. A dual role for a polyketide synthase in dynemicin enediyne and anthraquinone biosynthesis. Nature Chemistry. 10: 231-236. PMID 29359752 DOI: 10.1038/Nchem.2876 |
0.321 |
|
| 2018 |
Cohen DR, Townsend CA. Rücktitelbild: Characterization of an Anthracene Intermediate in Dynemicin Biosynthesis (Angew. Chem. 20/2018) Angewandte Chemie. 130: 6062-6062. DOI: 10.1002/Ange.201803006 |
0.374 |
|
| 2017 |
Storm PA, Townsend CA. In trans hydrolysis of carrier protein-bound acyl intermediates by CitA during citrinin biosynthesis. Chemical Communications (Cambridge, England). PMID 29189834 DOI: 10.1039/C7Cc07079A |
0.374 |
|
| 2017 |
Oliver RA, Li R, Townsend CA. Monobactam formation in sulfazecin by a nonribosomal peptide synthetase thioesterase. Nature Chemical Biology. PMID 29155429 DOI: 10.1038/Nchembio.2526 |
0.311 |
|
| 2017 |
Mattoo R, Lloyd EP, Kaushik A, Kumar P, Brunelle JL, Townsend CA, Lamichhane G. LdtMav2, a nonclassical transpeptidase and susceptibility of Mycobacterium avium to carbapenems. Future Microbiology. PMID 28555497 DOI: 10.2217/Fmb-2016-0208 |
0.366 |
|
| 2017 |
Bianchet MA, Pan YH, Basta LAB, Saavedra H, Lloyd EP, Kumar P, Mattoo R, Townsend CA, Lamichhane G. Structural insight into the inactivation of Mycobacterium tuberculosis non-classical transpeptidase LdtMt2 by biapenem and tebipenem. Bmc Biochemistry. 18: 8. PMID 28545389 DOI: 10.1186/S12858-017-0082-4 |
0.427 |
|
| 2017 |
Barajas JF, Shakya G, Moreno G, Rivera H, Jackson DR, Topper CL, Vagstad AL, La Clair JJ, Townsend CA, Burkart MD, Tsai SC. Polyketide mimetics yield structural and mechanistic insights into product template domain function in nonreducing polyketide synthases. Proceedings of the National Academy of Sciences of the United States of America. PMID 28484029 DOI: 10.1073/Pnas.1609001114 |
0.748 |
|
| 2017 |
Storm PA, Herbst DA, Maier T, Townsend CA. Functional and Structural Analysis of Programmed C-Methylation in the Biosynthesis of the Fungal Polyketide Citrinin. Cell Chemical Biology. PMID 28238725 DOI: 10.1016/J.Chembiol.2017.01.008 |
0.383 |
|
| 2016 |
Outlaw VK, Zhou J, Bragg AE, Townsend CA. Unusual Blue-Shifted Acid-Responsive Photoluminescence Behavior in 6-Amino-8-cyanobenzo[1,2-b]indolizines. Rsc Advances. 6: 61249-61253. PMID 28580137 DOI: 10.1039/C6Ra10605F |
0.301 |
|
| 2016 |
Li R, Oliver RA, Townsend CA. Identification and Characterization of the Sulfazecin Monobactam Biosynthetic Gene Cluster. Cell Chemical Biology. PMID 28017601 DOI: 10.1016/J.Chembiol.2016.11.010 |
0.36 |
|
| 2016 |
Kumar P, Kaushik A, Lloyd EP, Li SG, Mattoo R, Ammerman NC, Bell DT, Perryman AL, Zandi TA, Ekins S, Ginell SL, Townsend CA, Freundlich JS, Lamichhane G. Non-classical transpeptidases yield insight into new antibacterials. Nature Chemical Biology. PMID 27820797 DOI: 10.1038/Nchembio.2237 |
0.444 |
|
| 2016 |
Townsend CA. Convergent biosynthetic pathways to β-lactam antibiotics. Current Opinion in Chemical Biology. 35: 97-108. PMID 27693891 DOI: 10.1016/J.Cbpa.2016.09.013 |
0.401 |
|
| 2016 |
Barajas JF, Finzel K, Valentic TR, Shakya G, Gamarra N, Martinez D, Meier JL, Vagstad AL, Newman AG, Townsend CA, Burkart MD, Tsai SC. Structural and Biochemical Analysis of Protein-Protein Interactions Between the Acyl-Carrier Protein and Product Template Domain. Angewandte Chemie (International Ed. in English). PMID 27653519 DOI: 10.1002/Anie.201605401 |
0.738 |
|
| 2016 |
Newman AG, Townsend CA. Molecular Characterization of the Cercosporin Biosynthetic Pathway in the Fungal Plant Pathogen Cercospora nicotianae. Journal of the American Chemical Society. PMID 26938470 DOI: 10.1021/Jacs.6B00633 |
0.369 |
|
| 2015 |
Brammer Basta LA, Ghosh A, Pan Y, Jean J, Lloyd EP, Townsend CA, Lamichhane G, Bianchet MA. Loss of a functionally and structurally distinct L,D-transpeptidase, LdtMt5, compromises cell wall integrity in Mycobacterium tuberculosis. The Journal of Biological Chemistry. PMID 26304120 DOI: 10.1074/Jbc.M115.660753 |
0.33 |
|
| 2015 |
Conradt D, Schätzle MA, Haas J, Townsend CA, Müller M. New Insights into the Conversion of Versicolorin A in the Biosynthesis of Aflatoxin B1. Journal of the American Chemical Society. 137: 10867-9. PMID 26266881 DOI: 10.1021/Jacs.5B06770 |
0.366 |
|
| 2015 |
Marous DR, Lloyd EP, Buller AR, Moshos KA, Grove TL, Blaszczyk AJ, Booker SJ, Townsend CA. Consecutive radical S-adenosylmethionine methylations form the ethyl side chain in thienamycin biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 112: 10354-8. PMID 26240322 DOI: 10.1073/Pnas.1508615112 |
0.8 |
|
| 2015 |
Huitt-Roehl CR, Hill EA, Adams MM, Vagstad AL, Li JW, Townsend CA. Starter Unit Flexibility for Engineered Product Synthesis by the Nonreducing Polyketide Synthase PksA. Acs Chemical Biology. 10: 1443-9. PMID 25714897 DOI: 10.1021/Acschembio.5B00005 |
0.819 |
|
| 2015 |
Gaudelli NM, Long DH, Townsend CA. β-Lactam formation by a non-ribosomal peptide synthetase during antibiotic biosynthesis. Nature. 520: 383-7. PMID 25624104 DOI: 10.1038/Nature14100 |
0.358 |
|
| 2014 |
Townsend CA. Aflatoxin and deconstruction of type I, iterative polyketide synthase function. Natural Product Reports. 31: 1260-5. PMID 25079257 DOI: 10.1039/C4Np00092G |
0.363 |
|
| 2014 |
Outlaw VK, Wydysh EA, Vadlamudi A, Medghalchi SM, Townsend CA. Design, Synthesis, and Evaluation of 4- and 5-Substituted o-(Octanesulfonamido)benzoic Acids as Inhibitors of Glycerol-3-Phosphate Acyltransferase. Medchemcomm. 5: 826-830. PMID 25068033 DOI: 10.1039/C4Md00126E |
0.804 |
|
| 2014 |
Buller AR, Freeman MF, Schildbach JF, Townsend CA. Exploring the role of conformational heterogeneity in cis-autoproteolytic activation of ThnT. Biochemistry. 53: 4273-81. PMID 24933323 DOI: 10.1021/Bi500385D |
0.785 |
|
| 2014 |
Newman AG, Vagstad AL, Storm PA, Townsend CA. Systematic domain swaps of iterative, nonreducing polyketide synthases provide a mechanistic understanding and rationale for catalytic reprogramming. Journal of the American Chemical Society. 136: 7348-62. PMID 24815013 DOI: 10.1021/Ja5007299 |
0.757 |
|
| 2014 |
Gaudelli NM, Townsend CA. Epimerization and substrate gating by a TE domain in β-lactam antibiotic biosynthesis. Nature Chemical Biology. 10: 251-8. PMID 24531841 DOI: 10.1038/Nchembio.1456 |
0.354 |
|
| 2014 |
Li R, Lloyd EP, Moshos KA, Townsend CA. Identification and characterization of the carbapenem MM 4550 and its gene cluster in Streptomyces argenteolus ATCC 11009. Chembiochem : a European Journal of Chemical Biology. 15: 320-31. PMID 24420617 DOI: 10.1002/Cbic.201300319 |
0.781 |
|
| 2013 |
Townsend CA. Enzymology: Modular biosynthesis branches out. Nature. 502: 44-5. PMID 24048474 DOI: 10.1038/Nature12562 |
0.415 |
|
| 2013 |
Belecki K, Townsend CA. Biochemical determination of enzyme-bound metabolites: preferential accumulation of a programmed octaketide on the enediyne polyketide synthase CalE8. Journal of the American Chemical Society. 135: 14339-48. PMID 24041368 DOI: 10.1021/Ja406697T |
0.385 |
|
| 2013 |
Bruegger J, Haushalter RW, Haushalter B, Vagstad AL, Vagstad A, Shakya G, Mih N, Townsend CA, Burkart MD, Tsai SC. Probing the selectivity and protein·protein interactions of a nonreducing fungal polyketide synthase using mechanism-based crosslinkers. Chemistry & Biology. 20: 1135-46. PMID 23993461 DOI: 10.1016/J.Chembiol.2013.07.012 |
0.714 |
|
| 2013 |
Gaudelli NM, Townsend CA. Stereocontrolled syntheses of peptide thioesters containing modified seryl residues as probes of antibiotic biosynthesis. The Journal of Organic Chemistry. 78: 6412-26. PMID 23758494 DOI: 10.1021/Jo4007893 |
0.321 |
|
| 2013 |
Phelan RM, Townsend CA. Mechanistic insights into the bifunctional non-heme iron oxygenase carbapenem synthase by active site saturation mutagenesis. Journal of the American Chemical Society. 135: 7496-502. PMID 23611403 DOI: 10.1021/Ja311078S |
0.784 |
|
| 2013 |
Buller AR, Townsend CA. Intrinsic evolutionary constraints on protease structure, enzyme acylation, and the identity of the catalytic triad. Proceedings of the National Academy of Sciences of the United States of America. 110: E653-61. PMID 23382230 DOI: 10.1073/Pnas.1221050110 |
0.744 |
|
| 2013 |
Davidsen JM, Bartley DM, Townsend CA. Non-ribosomal propeptide precursor in nocardicin A biosynthesis predicted from adenylation domain specificity dependent on the MbtH family protein NocI. Journal of the American Chemical Society. 135: 1749-59. PMID 23330869 DOI: 10.1021/Ja307710D |
0.763 |
|
| 2013 |
Vagstad AL, Newman AG, Storm PA, Belecki K, Crawford JM, Townsend CA. Combinatorial domain swaps provide insights into the rules of fungal polyketide synthase programming and the rational synthesis of non-native aromatic products. Angewandte Chemie (International Ed. in English). 52: 1718-21. PMID 23283670 DOI: 10.1002/Anie.201208550 |
0.81 |
|
| 2013 |
Labonte JW, Townsend CA. Active site comparisons and catalytic mechanisms of the hot dog superfamily. Chemical Reviews. 113: 2182-204. PMID 23205964 DOI: 10.1021/Cr300169A |
0.746 |
|
| 2012 |
Labonte JW, Kudo F, Freeman MF, Raber ML, Townsend CA. Engineering the synthetic potential of β-lactam synthetase and the importance of catalytic loop dynamics. Medchemcomm. 3: 960-966. PMID 23616913 DOI: 10.1039/C2Md00305H |
0.79 |
|
| 2012 |
Vagstad AL, Hill EA, Labonte JW, Townsend CA. Characterization of a fungal thioesterase having Claisen cyclase and deacetylase activities in melanin biosynthesis. Chemistry & Biology. 19: 1525-34. PMID 23261597 DOI: 10.1016/j.chembiol.2012.10.002 |
0.814 |
|
| 2012 |
Newman AG, Vagstad AL, Belecki K, Scheerer JR, Townsend CA. Analysis of the cercosporin polyketide synthase CTB1 reveals a new fungal thioesterase function. Chemical Communications (Cambridge, England). 48: 11772-4. PMID 23108075 DOI: 10.1039/C2Cc36010A |
0.742 |
|
| 2012 |
Foulke-Abel J, Townsend CA. Demonstration of starter unit interprotein transfer from a fatty acid synthase to a multidomain, nonreducing polyketide synthase. Chembiochem : a European Journal of Chemical Biology. 13: 1880-4. PMID 22807303 DOI: 10.1002/Cbic.201200267 |
0.395 |
|
| 2012 |
Buller AR, Labonte JW, Freeman MF, Wright NT, Schildbach JF, Townsend CA. Autoproteolytic activation of ThnT results in structural reorganization necessary for substrate binding and catalysis. Journal of Molecular Biology. 422: 508-18. PMID 22706025 DOI: 10.1016/J.Jmb.2012.06.012 |
0.813 |
|
| 2012 |
Vagstad AL, Bumpus SB, Belecki K, Kelleher NL, Townsend CA. Interrogation of global active site occupancy of a fungal iterative polyketide synthase reveals strategies for maintaining biosynthetic fidelity. Journal of the American Chemical Society. 134: 6865-77. PMID 22452347 DOI: 10.1021/Ja3016389 |
0.762 |
|
| 2012 |
Jensen K, Niederkrüger H, Zimmermann K, Vagstad AL, Moldenhauer J, Brendel N, Frank S, Pöplau P, Kohlhaas C, Townsend CA, Oldiges M, Hertweck C, Piel J. Polyketide proofreading by an acyltransferase-like enzyme. Chemistry & Biology. 19: 329-39. PMID 22444588 DOI: 10.1016/J.Chembiol.2012.01.005 |
0.8 |
|
| 2012 |
Phelan RM, DiPardo BJ, Townsend CA. A high-throughput screen for the engineered production of β-lactam antibiotics. Acs Chemical Biology. 7: 835-40. PMID 22428872 DOI: 10.1021/Cb200504G |
0.742 |
|
| 2012 |
Davidsen JM, Townsend CA. In vivo characterization of nonribosomal peptide synthetases NocA and NocB in the biosynthesis of nocardicin A. Chemistry & Biology. 19: 297-306. PMID 22365611 DOI: 10.1016/J.Chembiol.2011.10.020 |
0.746 |
|
| 2012 |
Buller AR, Freeman MF, Wright NT, Schildbach JF, Townsend CA. Insights into cis-autoproteolysis reveal a reactive state formed through conformational rearrangement. Proceedings of the National Academy of Sciences of the United States of America. 109: 2308-13. PMID 22308359 DOI: 10.1073/Pnas.1113633109 |
0.781 |
|
| 2011 |
Bodner MJ, Li R, Phelan RM, Freeman MF, Moshos KA, Lloyd EP, Townsend CA. Definition of the common and divergent steps in carbapenem β-lactam antibiotic biosynthesis. Chembiochem : a European Journal of Chemical Biology. 12: 2159-65. PMID 21913298 DOI: 10.1002/Cbic.201100366 |
0.801 |
|
| 2011 |
Townsend CA. A "diels-alderase" at last. Chembiochem : a European Journal of Chemical Biology. 12: 2267-9. PMID 21796752 DOI: 10.1002/Cbic.201100431 |
0.361 |
|
| 2011 |
Kuhajda FP, Aja S, Tu Y, Han WF, Medghalchi SM, El Meskini R, Landree LE, Peterson JM, Daniels K, Wong K, Wydysh EA, Townsend CA, Ronnett GV. Pharmacological glycerol-3-phosphate acyltransferase inhibition decreases food intake and adiposity and increases insulin sensitivity in diet-induced obesity. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 301: R116-30. PMID 21490364 DOI: 10.1152/Ajpregu.00147.2011 |
0.763 |
|
| 2010 |
Crawford JM, Townsend CA. New insights into the formation of fungal aromatic polyketides. Nature Reviews. Microbiology. 8: 879-89. PMID 21079635 DOI: 10.1038/Nrmicro2465 |
0.615 |
|
| 2010 |
Wydysh EA, Vadlamudi A, Medghalchi SM, Townsend CA. Design, synthesis, and biological evaluation of conformationally constrained glycerol 3-phosphate acyltransferase inhibitors. Bioorganic & Medicinal Chemistry. 18: 6470-9. PMID 20692840 DOI: 10.1016/J.Bmc.2010.06.091 |
0.804 |
|
| 2010 |
Korman TP, Crawford JM, Labonte JW, Newman AG, Wong J, Townsend CA, Tsai SC. Structure and function of an iterative polyketide synthase thioesterase domain catalyzing Claisen cyclization in aflatoxin biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 107: 6246-51. PMID 20332208 DOI: 10.1073/Pnas.0913531107 |
0.805 |
|
| 2010 |
Ehrlich KC, Chang PK, Scharfenstein LL, Cary JW, Crawford JM, Townsend CA. Absence of the aflatoxin biosynthesis gene, norA, allows accumulation of deoxyaflatoxin B1 in Aspergillus flavus cultures. Fems Microbiology Letters. 305: 65-70. PMID 20158523 DOI: 10.1111/J.1574-6968.2010.01914.X |
0.588 |
|
| 2010 |
Bodner MJ, Phelan RM, Freeman MF, Li R, Townsend CA. Non-heme iron oxygenases generate natural structural diversity in carbapenem antibiotics. Journal of the American Chemical Society. 132: 12-3. PMID 20017478 DOI: 10.1021/Ja907320N |
0.801 |
|
| 2009 |
Raber ML, Castillo A, Greer A, Townsend CA. A conserved lysine in beta-lactam synthetase assists ring cyclization: Implications for clavam and carbapenem biosynthesis. Chembiochem : a European Journal of Chemical Biology. 10: 2904-12. PMID 19882698 DOI: 10.1002/Cbic.200900389 |
0.803 |
|
| 2009 |
Crawford JM, Korman TP, Labonte JW, Vagstad AL, Hill EA, Kamari-Bidkorpeh O, Tsai SC, Townsend CA. Structural basis for biosynthetic programming of fungal aromatic polyketide cyclization. Nature. 461: 1139-43. PMID 19847268 DOI: 10.1038/Nature08475 |
0.81 |
|
| 2009 |
Belecki K, Crawford JM, Townsend CA. Production of octaketide polyenes by the calicheamicin polyketide synthase CalE8: implications for the biosynthesis of enediyne core structures. Journal of the American Chemical Society. 131: 12564-6. PMID 19689130 DOI: 10.1021/Ja904391R |
0.65 |
|
| 2009 |
Bodner MJ, Phelan RM, Townsend CA. A catalytic asymmetric route to carbapenems. Organic Letters. 11: 3606-9. PMID 19610642 DOI: 10.1021/Ol901269D |
0.762 |
|
| 2009 |
Sohka T, Heins RA, Phelan RM, Greisler JM, Townsend CA, Ostermeier M. An externally tunable bacterial band-pass filter. Proceedings of the National Academy of Sciences of the United States of America. 106: 10135-40. PMID 19502423 DOI: 10.1073/Pnas.0901246106 |
0.739 |
|
| 2009 |
Wydysh EA, Medghalchi SM, Vadlamudi A, Townsend CA. Design and synthesis of small molecule glycerol 3-phosphate acyltransferase inhibitors. Journal of Medicinal Chemistry. 52: 3317-27. PMID 19388675 DOI: 10.1021/Jm900251A |
0.801 |
|
| 2009 |
Raber ML, Arnett SO, Townsend CA. A conserved tyrosyl-glutamyl catalytic dyad in evolutionarily linked enzymes: carbapenam synthetase and beta-lactam synthetase. Biochemistry. 48: 4959-71. PMID 19371088 DOI: 10.1021/Bi900432N |
0.782 |
|
| 2009 |
Phelan RM, Ostermeier M, Townsend CA. Design and synthesis of a beta-lactamase activated 5-fluorouracil prodrug. Bioorganic & Medicinal Chemistry Letters. 19: 1261-3. PMID 19167216 DOI: 10.1016/J.Bmcl.2008.12.057 |
0.745 |
|
| 2009 |
Davidsen JM, Townsend CA. Identification and characterization of NocR as a positive transcriptional regulator of the beta-lactam nocardicin A in Nocardia uniformis. Journal of Bacteriology. 191: 1066-77. PMID 19028891 DOI: 10.1128/Jb.01833-07 |
0.762 |
|
| 2009 |
Raber ML, Freeman MF, Townsend CA. Dissection of the stepwise mechanism to beta-lactam formation and elucidation of a rate-determining conformational change in beta-lactam synthetase. The Journal of Biological Chemistry. 284: 207-17. PMID 18955494 DOI: 10.1074/Jbc.M805390200 |
0.795 |
|
| 2008 |
Freeman MF, Moshos KA, Bodner MJ, Li R, Townsend CA. Four enzymes define the incorporation of coenzyme A in thienamycin biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 105: 11128-33. PMID 18678912 DOI: 10.1073/Pnas.0804500105 |
0.818 |
|
| 2008 |
Townsend C. Peering inside the black box to find enzyme-bound intermediates. Nature Chemical Biology. 4: 390-1. PMID 18560428 DOI: 10.1038/Nchembio0708-390 |
0.381 |
|
| 2008 |
Crawford JM, Vagstad AL, Ehrlich KC, Udwary DW, Townsend CA. Acyl-carrier protein-phosphopantetheinyltransferase partnerships in fungal fatty acid synthases. Chembiochem : a European Journal of Chemical Biology. 9: 1559-63. PMID 18551496 DOI: 10.1002/Cbic.200700659 |
0.809 |
|
| 2008 |
Crawford JM, Thomas PM, Scheerer JR, Vagstad AL, Kelleher NL, Townsend CA. Deconstruction of iterative multidomain polyketide synthase function. Science (New York, N.Y.). 320: 243-6. PMID 18403714 DOI: 10.1126/Science.1154711 |
0.792 |
|
| 2008 |
Crawford JM, Vagstad AL, Whitworth KP, Ehrlich KC, Townsend CA. Synthetic strategy of nonreducing iterative polyketide synthases and the origin of the classical "starter-unit effect". Chembiochem : a European Journal of Chemical Biology. 9: 1019-23. PMID 18338425 DOI: 10.1002/Cbic.200700702 |
0.813 |
|
| 2008 |
Crawford JM, Vagstad AL, Ehrlich KC, Townsend CA. Starter unit specificity directs genome mining of polyketide synthase pathways in fungi. Bioorganic Chemistry. 36: 16-22. PMID 18215412 DOI: 10.1016/J.Bioorg.2007.11.002 |
0.796 |
|
| 2007 |
Merski M, Townsend CA. Observation of an acryloyl-thiamin diphosphate adduct in the first step of clavulanic acid biosynthesis. Journal of the American Chemical Society. 129: 15750-1. PMID 18052280 DOI: 10.1021/Ja076704R |
0.795 |
|
| 2007 |
Arnett SO, Gerratana B, Townsend CA. Rate-limiting steps and role of active site Lys443 in the mechanism of carbapenam synthetase. Biochemistry. 46: 9337-45. PMID 17658887 DOI: 10.1021/Bi0618464 |
0.813 |
|
| 2007 |
Zhou W, Han WF, Landree LE, Thupari JN, Pinn ML, Bililign T, Kim EK, Vadlamudi A, Medghalchi SM, El Meskini R, Ronnett GV, Townsend CA, Kuhajda FP. Fatty acid synthase inhibition activates AMP-activated protein kinase in SKOV3 human ovarian cancer cells. Cancer Research. 67: 2964-71. PMID 17409402 DOI: 10.1158/0008-5472.Can-06-3439 |
0.37 |
|
| 2006 |
Crawford JM, Dancy BC, Hill EA, Udwary DW, Townsend CA. Identification of a starter unit acyl-carrier protein transacylase domain in an iterative type I polyketide synthase. Proceedings of the National Academy of Sciences of the United States of America. 103: 16728-33. PMID 17071746 DOI: 10.1073/Pnas.0604112103 |
0.807 |
|
| 2006 |
Townsend CA, Crawford JM, Bililign T. New images evoke FAScinating questions. Chemistry & Biology. 13: 349-51. PMID 16632247 DOI: 10.1016/J.Chembiol.2006.04.001 |
0.572 |
|
| 2006 |
Li R, Townsend CA. Rational strain improvement for enhanced clavulanic acid production by genetic engineering of the glycolytic pathway in Streptomyces clavuligerus. Metabolic Engineering. 8: 240-52. PMID 16530442 DOI: 10.1016/J.Ymben.2006.01.003 |
0.368 |
|
| 2006 |
Müller U, van Assema F, Gunsior M, Orf S, Kremer S, Schipper D, Wagemans A, Townsend CA, Sonke T, Bovenberg R, Wubbolts M. Metabolic engineering of the E. coli L-phenylalanine pathway for the production of D-phenylglycine (D-Phg). Metabolic Engineering. 8: 196-208. PMID 16466681 DOI: 10.1016/J.Ymben.2005.12.001 |
0.739 |
|
| 2006 |
Hughes MA, Silva JC, Geromanos SJ, Townsend CA. Quantitative proteomic analysis of drug-induced changes in mycobacteria. Journal of Proteome Research. 5: 54-63. PMID 16396495 DOI: 10.1021/Pr050248T |
0.578 |
|
| 2005 |
Hughes MA, McFadden JM, Townsend CA. New alpha-methylene-gamma-butyrolactones with antimycobacterial properties. Bioorganic & Medicinal Chemistry Letters. 15: 3857-9. PMID 16002282 DOI: 10.1016/J.Bmcl.2005.05.119 |
0.589 |
|
| 2005 |
Henry KM, Townsend CA. Ordering the reductive and cytochrome P450 oxidative steps in demethylsterigmatocystin formation yields general insights into the biosynthesis of aflatoxin and related fungal metabolites. Journal of the American Chemical Society. 127: 3724-33. PMID 15771506 DOI: 10.1021/Ja0455188 |
0.674 |
|
| 2005 |
Henry KM, Townsend CA. Synthesis and fate of o-carboxybenzophenones in the biosynthesis of aflatoxin. Journal of the American Chemical Society. 127: 3300-9. PMID 15755146 DOI: 10.1021/Ja045520Z |
0.657 |
|
| 2005 |
McFadden JM, Medghalchi SM, Thupari JN, Pinn ML, Vadlamudi A, Miller KI, Kuhajda FP, Townsend CA. Application of a flexible synthesis of (5R)-thiolactomycin to develop new inhibitors of type I fatty acid synthase. Journal of Medicinal Chemistry. 48: 946-61. PMID 15715465 DOI: 10.1021/Jm049389H |
0.321 |
|
| 2005 |
Kelly WL, Townsend CA. Mutational analysis of nocK and nocL in the nocardicin a producer Nocardia uniformis. Journal of Bacteriology. 187: 739-46. PMID 15629944 DOI: 10.1128/Jb.187.2.739-746.2005 |
0.727 |
|
| 2005 |
Hughes MA, McFadden JM, Townsend CA. New α-Methylene-γ-butyrolactones with Antimycobacterial Properties. Cheminform. 36. DOI: 10.1002/chin.200550103 |
0.475 |
|
| 2004 |
Gerratana B, Arnett SO, Stapon A, Townsend CA. Carboxymethylproline synthase from Pectobacterium carotorova: a multifaceted member of the crotonase superfamily. Biochemistry. 43: 15936-45. PMID 15595850 DOI: 10.1021/Bi0483662 |
0.802 |
|
| 2004 |
Parrish NM, Ko CG, Hughes MA, Townsend CA, Dick JD. Effect of n-octanesulphonylacetamide (OSA) on ATP and protein expression in Mycobacterium bovis BCG. The Journal of Antimicrobial Chemotherapy. 54: 722-9. PMID 15355939 DOI: 10.1093/Jac/Dkh408 |
0.615 |
|
| 2004 |
Gunsior M, Breazeale SD, Lind AJ, Ravel J, Janc JW, Townsend CA. The biosynthetic gene cluster for a monocyclic beta-lactam antibiotic, nocardicin A. Chemistry & Biology. 11: 927-38. PMID 15271351 DOI: 10.1016/J.Chembiol.2004.04.012 |
0.804 |
|
| 2004 |
Chiou CH, Lee LW, Owens SA, Whallon JH, Klomparens KL, Townsend CA, Linz JE. Distribution and sub-cellular localization of the aflatoxin enzyme versicolorin B synthase in time-fractionated colonies of Aspergillus parasiticus. Archives of Microbiology. 182: 67-79. PMID 15258720 DOI: 10.1007/S00203-004-0700-6 |
0.37 |
|
| 2004 |
Kelly WL, Townsend CA. Mutational analysis and characterization of nocardicin C-9' epimerase. The Journal of Biological Chemistry. 279: 38220-7. PMID 15252031 DOI: 10.1074/Jbc.M405450200 |
0.732 |
|
| 2004 |
Gunsior M, Ravel J, Challis GL, Townsend CA. Engineering p-hydroxyphenylpyruvate dioxygenase to a p-hydroxymandelate synthase and evidence for the proposed benzene oxide intermediate in homogentisate formation. Biochemistry. 43: 663-74. PMID 14730970 DOI: 10.1021/Bi035762W |
0.773 |
|
| 2003 |
Stapon A, Li R, Townsend CA. Synthesis of (3S,5R)-carbapenam-3-carboxylic acid and its role in carbapenem biosynthesis and the stereoinversion problem. Journal of the American Chemical Society. 125: 15746-7. PMID 14677956 DOI: 10.1021/Ja037665W |
0.8 |
|
| 2003 |
Miller MT, Gerratana B, Stapon A, Townsend CA, Rosenzweig AC. Crystal structure of carbapenam synthetase (CarA). The Journal of Biological Chemistry. 278: 40996-1002. PMID 12890666 DOI: 10.1074/Jbc.M307901200 |
0.819 |
|
| 2003 |
Stapon A, Li R, Townsend CA. Carbapenem biosynthesis: confirmation of stereochemical assignments and the role of CarC in the ring stereoinversion process from L-proline. Journal of the American Chemical Society. 125: 8486-93. PMID 12848554 DOI: 10.1021/Ja034248A |
0.81 |
|
| 2003 |
Gerratana B, Stapon A, Townsend CA. Inhibition and alternate substrate studies on the mechanism of carbapenam synthetase from Erwinia carotovora. Biochemistry. 42: 7836-47. PMID 12820893 DOI: 10.1021/Bi034361D |
0.828 |
|
| 2002 |
McFadden JM, Frehywot GL, Townsend CA. A flexible route to (5R)-thiolactomycin, a naturally occurring inhibitor of fatty acid synthesis. Organic Letters. 4: 3859-62. PMID 12599477 DOI: 10.1021/Ol026685K |
0.782 |
|
| 2002 |
Townsend CA. New reactions in clavulanic acid biosynthesis. Current Opinion in Chemical Biology. 6: 583-9. PMID 12413541 DOI: 10.1016/S1367-5931(02)00392-7 |
0.411 |
|
| 2002 |
Miller MT, Bachmann BO, Townsend CA, Rosenzweig AC. The catalytic cycle of beta -lactam synthetase observed by x-ray crystallographic snapshots. Proceedings of the National Academy of Sciences of the United States of America. 99: 14752-7. PMID 12409610 DOI: 10.1073/Pnas.232361199 |
0.641 |
|
| 2002 |
Udwary DW, Merski M, Townsend CA. A method for prediction of the locations of linker regions within large multifunctional proteins, and application to a type I polyketide synthase. Journal of Molecular Biology. 323: 585-98. PMID 12381311 DOI: 10.1016/S0022-2836(02)00972-5 |
0.779 |
|
| 2002 |
Watanabe CM, Townsend CA. Initial characterization of a type I fatty acid synthase and polyketide synthase multienzyme complex NorS in the biosynthesis of aflatoxin B(1). Chemistry & Biology. 9: 981-8. PMID 12323372 DOI: 10.1016/S1074-5521(02)00213-2 |
0.404 |
|
| 2002 |
Kelly WL, Townsend CA. Role of the cytochrome P450 NocL in nocardicin A biosynthesis. Journal of the American Chemical Society. 124: 8186-7. PMID 12105888 DOI: 10.1021/Ja025926G |
0.719 |
|
| 2002 |
Udwary DW, Casillas LK, Townsend CA. Synthesis of 11-hydroxyl O-methylsterigmatocystin and the role of a cytochrome P-450 in the final step of aflatoxin biosynthesis. Journal of the American Chemical Society. 124: 5294-303. PMID 11996570 DOI: 10.1021/Ja012185V |
0.757 |
|
| 2001 |
Hitchman TS, Schmidt EW, Trail F, Rarick MD, Linz JE, Townsend CA. Hexanoate synthase, a specialized type I fatty acid synthase in aflatoxin B1 biosynthesis. Bioorganic Chemistry. 29: 293-307. PMID 16256699 DOI: 10.1006/Bioo.2001.1216 |
0.617 |
|
| 2001 |
Miller MT, Bachmann BO, Townsend CA, Rosenzweig AC. Structure of beta-lactam synthetase reveals how to synthesize antibiotics instead of asparagine. Nature Structural Biology. 8: 684-9. PMID 11473258 DOI: 10.1038/90394 |
0.638 |
|
| 2001 |
Zhou J, Kelly WL, Bachmann BO, Gunsior M, Townsend CA, Solomon EI. Spectroscopic studies of substrate interactions with clavaminate synthase 2, a multifunctional alpha-KG-dependent non-heme iron enzyme: correlation with mechanisms and reactivities. Journal of the American Chemical Society. 123: 7388-98. PMID 11472170 DOI: 10.1021/Ja004025+ |
0.796 |
|
| 2001 |
Parrish NM, Houston T, Jones PB, Townsend C, Dick JD. In vitro activity of a novel antimycobacterial compound, N-octanesulfonylacetamide, and its effects on lipid and mycolic acid synthesis. Antimicrobial Agents and Chemotherapy. 45: 1143-50. PMID 11257028 DOI: 10.1128/Aac.45.4.1143-1150.2001 |
0.329 |
|
| 2000 |
Bachmann BO, Townsend CA. Kinetic mechanism of the beta-lactam synthetase of Streptomyces clavuligerus. Biochemistry. 39: 11187-93. PMID 10985764 DOI: 10.1021/Bi000709I |
0.681 |
|
| 2000 |
Jones PB, Parrish NM, Houston TA, Stapon A, Bansal NP, Dick JD, Townsend CA. A new class of antituberculosis agents. Journal of Medicinal Chemistry. 43: 3304-14. PMID 10966749 DOI: 10.1021/Jm000149L |
0.798 |
|
| 2000 |
Khaleeli N, Busby RW, Townsend CA. Site-directed mutagenesis and biochemical analysis of the endogenous ligands in the ferrous active site of clavaminate synthase. The His-3 variant of the 2-His-1-carboxylate model. Biochemistry. 39: 8666-73. PMID 10913275 DOI: 10.1021/Bi000534C |
0.393 |
|
| 2000 |
Loftus TM, Jaworsky DE, Frehywot GL, Townsend CA, Ronnett GV, Lane MD, Kuhajda FP. Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors. Science (New York, N.Y.). 288: 2379-81. PMID 10875926 DOI: 10.1126/Science.288.5475.2379 |
0.779 |
|
| 2000 |
Li R, Khaleeli N, Townsend CA. Expansion of the clavulanic acid gene cluster: identification and in vivo functional analysis of three new genes required for biosynthesis of clavulanic acid by Streptomyces clavuligerus. Journal of Bacteriology. 182: 4087-95. PMID 10869089 DOI: 10.1128/Jb.182.14.4087-4095.2000 |
0.414 |
|
| 2000 |
Kuhajda FP, Pizer ES, Li JN, Mani NS, Frehywot GL, Townsend CA. Synthesis and antitumor activity of an inhibitor of fatty acid synthase. Proceedings of the National Academy of Sciences of the United States of America. 97: 3450-4. PMID 10716717 DOI: 10.1073/pnas.050582897 |
0.796 |
|
| 2000 |
Challis GL, Ravel J, Townsend CA. Predictive, structure-based model of amino acid recognition by nonribosomal peptide synthetase adenylation domains. Chemistry & Biology. 7: 211-24. PMID 10712928 DOI: 10.1016/S1074-5521(00)00091-0 |
0.393 |
|
| 2000 |
Pizer ES, Thupari J, Han WF, Pinn ML, Chrest FJ, Frehywot GL, Townsend CA, Kuhajda FP. Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts. Cancer Research. 60: 213-8. PMID 10667561 |
0.782 |
|
| 2000 |
Keller NP, Watanabe CM, Kelkar HS, Adams TH, Townsend CA. Requirement of monooxygenase-mediated steps for sterigmatocystin biosynthesis by Aspergillus nidulans. Applied and Environmental Microbiology. 66: 359-62. PMID 10618248 DOI: 10.1128/Aem.66.1.359-362.2000 |
0.362 |
|
| 2000 |
Wu M, Stoermer D, Tullius TD, Townsend CA. Calicheamicin - Homeodomain conjugate as an efficient, sequence-specific DNA cleavage and mapping tool [11] Journal of the American Chemical Society. 122: 12884-12885. DOI: 10.1021/Ja002280O |
0.463 |
|
| 2000 |
Li R, Stapon A, Blanchfield JT, Townsend CA. Three unusual reactions mediate carbapenem and carbapenam biosynthesis [1] Journal of the American Chemical Society. 122: 9296-9297. DOI: 10.1021/Ja001723L |
0.776 |
|
| 1999 |
Iwata-Reuyl D, Basak A, Townsend CA. β-Secondary kinetic isotope effects in the clavaminate synthase- catalyzed oxidative cyclization of proclavaminic acid and in related azetidinone model reactions Journal of the American Chemical Society. 121: 11356-11368. DOI: 10.1021/Ja992649D |
0.388 |
|
| 1999 |
Khaleeli N, Li R, Townsend CA. Origin of the β-lactam carbons in clavulanic acid from an unusual thiamine pyrophosphate-mediated reaction [3] Journal of the American Chemical Society. 121: 9223-9224. DOI: 10.1021/Ja9923134 |
0.309 |
|
| 1999 |
Graybill TL, Casillas EG, Pal K, Townsend CA. Silyl triflate-mediated ring-closure and rearrangement in the synthesis of potential bisfuran-containing intermediates of aflatoxin biosynthesis Journal of the American Chemical Society. 121: X. DOI: 10.1021/Ja990591X |
0.343 |
|
| 1998 |
Reeve AM, Breazeale SD, Townsend CA. Purification, characterization, and cloning of an S-adenosylmethionine-dependent 3-amino-3-carboxypropyltransferase in nocardicin biosynthesis. The Journal of Biological Chemistry. 273: 30695-703. PMID 9804844 DOI: 10.1074/Jbc.273.46.30695 |
0.824 |
|
| 1998 |
Bachmann BO, Li R, Townsend CA. beta-Lactam synthetase: a new biosynthetic enzyme. Proceedings of the National Academy of Sciences of the United States of America. 95: 9082-6. PMID 9689037 DOI: 10.1073/Pnas.95.16.9082 |
0.668 |
|
| 1998 |
Zhou J, Gunsior M, Bachmann BO, Townsend CA, Solomon EI. Substrate binding to the α-ketoglutarate-dependent non-heme iron enzyme clavaminate synthase 2: Coupling mechanism of oxidative decarboxylation and hydroxylation [14] Journal of the American Chemical Society. 120: 13539-13540. DOI: 10.1021/Ja983534X |
0.789 |
|
| 1998 |
Watanabe CMH, Townsend CA. The in vitro conversion of norsolorinic acid to aflatoxin B1. An improved method of cell-free enzyme preparation and stabilization Journal of the American Chemical Society. 120: 6231-6239. DOI: 10.1021/Ja974367O |
0.379 |
|
| 1998 |
Pavel EG, Zhou J, Busby RW, Gunsior M, Townsend CA, Solomon EI. Circular dichroism and magnetic circular dichroism spectroscopic studies of the non-heme ferrous active site in clavaminate synthase and its interaction with α-ketoglutarate cosubstrate Journal of the American Chemical Society. 120: 743-753. DOI: 10.1021/Ja972408A |
0.756 |
|
| 1997 |
Minto RE, Townsend CA. Enzymology and Molecular Biology of Aflatoxin Biosynthesis. Chemical Reviews. 97: 2537-2556. PMID 11851470 DOI: 10.1021/Cr960032Y |
0.682 |
|
| 1997 |
Mani NS, Townsend CA. A Concise Synthesis of (+)-Cerulenin from a Chiral Oxiranyllithium. The Journal of Organic Chemistry. 62: 636-640. PMID 11671457 DOI: 10.1021/Jo9618177 |
0.337 |
|
| 1997 |
Townsend CA. Structural studies of natural product biosynthetic proteins. Chemistry & Biology. 4: 721-30. PMID 9375250 DOI: 10.1016/S1074-5521(97)90310-0 |
0.355 |
|
| 1997 |
Silva JC, Townsend CA. Heterologous expression, isolation, and characterization of versicolorin B synthase from Aspergillus parasiticus. A key enzyme in the aflatoxin B1 biosynthetic pathway. The Journal of Biological Chemistry. 272: 804-13. PMID 8995367 DOI: 10.1074/Jbc.272.2.804 |
0.4 |
|
| 1997 |
Egan LA, Busby RW, Iwata-Reuyl D, Townsend CA. Probable role of clavaminic acid as the terminal intermediate in the common pathway to clavulanic acid and the antipodal clavam metabolites Journal of the American Chemical Society. 119: 2348-2355. DOI: 10.1021/Ja963107O |
0.405 |
|
| 1997 |
Pitlik J, Townsend CA. Solution-phase synthesis of a combinatorial monocyclic β-lactam library: Potential protease inhibitors Bioorganic and Medicinal Chemistry Letters. 7: 3129-3134. DOI: 10.1016/S0960-894X(97)10170-6 |
0.302 |
|
| 1996 |
Busby RW, Townsend CA. A single monomeric iron center in clavaminate synthase catalyzes three nonsuccessive oxidative transformations. Bioorganic & Medicinal Chemistry. 4: 1059-64. PMID 8831977 DOI: 10.1016/0968-0896(96)00088-0 |
0.38 |
|
| 1996 |
Watanabe CM, Wilson D, Linz JE, Townsend CA. Demonstration of the catalytic roles and evidence for the physical association of type I fatty acid synthases and a polyketide synthase in the biosynthesis of aflatoxin B1. Chemistry & Biology. 3: 463-9. PMID 8807876 DOI: 10.1016/S1074-5521(96)90094-0 |
0.404 |
|
| 1996 |
McGuire SM, Silva JC, Casillas EG, Townsend CA. Purification and characterization of versicolorin B synthase from Aspergillus parasiticus. Catalysis of the stereodifferentiating cyclization in aflatoxin biosynthesis essential to DNA interaction. Biochemistry. 35: 11470-86. PMID 8784203 DOI: 10.1021/Bi960924S |
0.429 |
|
| 1996 |
Silva JC, Minto RE, Barry CE, Holland KA, Townsend CA. Isolation and characterization of the versicolorin B synthase gene from Aspergillus parasiticus. Expansion of the aflatoxin b1 biosynthetic gene cluster. The Journal of Biological Chemistry. 271: 13600-8. PMID 8662689 DOI: 10.1074/Jbc.271.23.13600 |
0.746 |
|
| 1996 |
Watanabe CMH, Townsend CA. Incorporation of molecular oxygen in aflatoxin B1 biosynthesis Journal of Organic Chemistry. 61: 1990-1993. DOI: 10.1021/Jo952056V |
0.307 |
|
| 1995 |
Busby RW, Chang MD, Busby RC, Wimp J, Townsend CA. Expression and purification of two isozymes of clavaminate synthase and initial characterization of the iron binding site. General error analysis in polymerase chain reaction amplification. The Journal of Biological Chemistry. 270: 4262-9. PMID 7876185 DOI: 10.1074/Jbc.270.9.4262 |
0.392 |
|
| 1995 |
Wu TK, Busby RW, Houston TA, McIlwaine DB, Egan LA, Townsend CA. Identification, cloning, sequencing, and overexpression of the gene encoding proclavaminate amidino hydrolase and characterization of protein function in clavulanic acid biosynthesis. Journal of Bacteriology. 177: 3714-20. PMID 7601835 DOI: 10.1128/Jb.177.13.3714-3720.1995 |
0.433 |
|
| 1994 |
Brobst SW, Townsend CA. The potential role of fatty acid initiation in the biosynthesis of the fungal aromatic polyketide aflatoxin B1 Canadian Journal of Chemistry. 72: 200-207. DOI: 10.1139/V94-031 |
0.357 |
|
| 1993 |
Townsend CA. Oxidative amino aid processing in beta-lactam antibiotic biosynthesis. Biochemical Society Transactions. 21: 208-13. PMID 8449295 DOI: 10.1042/Bst0210208 |
0.326 |
|
| 1993 |
Iwata-Reuyl D, Basak A, Silverman LS, Engle CA, Townsend CA. Synthesis and reaction of potential alternate substrates and mechanism-based inhibitors of clavaminate synthase. Journal of Natural Products. 56: 1373-96. PMID 8229018 DOI: 10.1021/Np50098A022 |
0.646 |
|
| 1993 |
McGuire SM, Townsend CA. Demonstration of Baeyer-Villiger oxidation and the course of cyclization in bisfuran ring formation during aflatoxin B1 biosynthesis Bioorganic and Medicinal Chemistry Letters. 3: 653-656. DOI: 10.1016/S0960-894X(01)81247-6 |
0.306 |
|
| 1992 |
Marsh EN, Chang MD, Townsend CA. Two isozymes of clavaminate synthase central to clavulanic acid formation: cloning and sequencing of both genes from Streptomyces clavuligerus. Biochemistry. 31: 12648-57. PMID 1472501 DOI: 10.1021/Bi00165A015 |
0.401 |
|
| 1992 |
Iwata-Reuyl D, Townsend CA. Common origin of clavulanic acid and other clavan metabolites in Streptomyces Journal of the American Chemical Society. 114: 2762-2763. DOI: 10.1021/Ja00033A086 |
0.316 |
|
| 1991 |
Salowe SP, Krol WJ, Iwata-Reuyl D, Townsend CA. Elucidation of the order of oxidations and identification of an intermediate in the multistep clavaminate synthase reaction. Biochemistry. 30: 2281-92. PMID 1998687 DOI: 10.1021/Bi00222A034 |
0.375 |
|
| 1991 |
Townsend CA, Basak A. Experiments and speculations on the role of oxidative cyclization chemistry in natural product biosynthesis Tetrahedron. 47: 2591-2602. DOI: 10.1016/S0040-4020(01)81792-0 |
0.476 |
|
| 1990 |
Basak A, Salowe SP, Townsend CA. Stereochemical course of the key ring-forming reactions in clavulanic acid biosynthesis Journal of the American Chemical Society. 112: 1654-1656. DOI: 10.1021/Ja00160A069 |
0.581 |
|
| 1990 |
Basak A, Salowe SP, Townsend CA. Stereochemical course of the key ring-forming reactions in clavulanic acid biosynthesis Journal of the American Chemical Society. 112: 1654-1656. DOI: 10.1021/ja00160a069 |
0.53 |
|
| 1990 |
KROL WJ, BASAK A, SALOWE SP, TOWNSEND CA. ChemInform Abstract: Oxidative Cyclization Chemistry Catalyzed by Clavaminate Synthase. Cheminform. 21. DOI: 10.1002/chin.199002347 |
0.478 |
|
| 1989 |
Krol WJ, Basak A, Salowe SP, Townsend CA. Oxidative cyclization chemistry catalyzed by clavaminate synthase Journal of the American Chemical Society. 111: 7625-7627. DOI: 10.1021/Ja00201A060 |
0.531 |
|
| 1989 |
Krol WJ, Basak A, Salowe SP, Townsend CA. Oxidative cyclization chemistry catalyzed by clavaminate synthase Journal of the American Chemical Society. 111: 7625-7627. DOI: 10.1021/ja00201a060 |
0.475 |
|
| 1989 |
Townsend CA, Isomura Y, Davis SG, Hodge JA. Reaction Models of the Oxidative Rearrangement of Averufin to 1'- Hydroxyversicolorone: The First Step in Dihydrobisfuran Formation in Aflatoxin Biosynthesis Tetrahedron. 45: 2263-2276. DOI: 10.1016/S0040-4020(01)83431-1 |
0.325 |
|
| 1988 |
Townsend CA, Christensen SB, Davis SG. Synthesis of averufin and its role in aflatoxin B1 biosynthesis Journal of the Chemical Society, Perkin Transactions 1. 839-861. DOI: 10.1039/P19880000839 |
0.316 |
|
| 1988 |
Townsend CA, Krol WJ. The role of molecular oxygen in clavulanic acid biosynthesis: Evidence for a bacterial oxidative deamination Journal of the Chemical Society, Chemical Communications. 1234-1236. DOI: 10.1039/C39880001234 |
0.307 |
|
| 1988 |
Townsend CA, Whittamore PRO, Brobst SW. Hydroxyversicolorone: Synthesis and incorporation of a new intermediate in aflatoxin biosynthesis Journal of the Chemical Society, Chemical Communications. 726-728. DOI: 10.1039/C39880000726 |
0.323 |
|
| 1988 |
Townsend CA, Brobst SW, Ramer SE, Vederas JC. Stereochemical features of enoyl thiol ester reductase in averufin and fatty acid biosynthesis in Aspergillus parasiticus Journal of the American Chemical Society. 110: 318-319. DOI: 10.1021/Ja00209A066 |
0.338 |
|
| 1987 |
Townsend CA, Mao SS. Clavulanic acid biosynthesis: The stereochemical course of β-lactam formation from chiral glycerol Journal of the Chemical Society, Chemical Communications. 86-89. DOI: 10.1039/C39870000086 |
0.307 |
|
| 1986 |
Townsend CA. Progress toward a biosynthetic rationale of the aflatoxin pathway Pure and Applied Chemistry. 58: 227-238. DOI: 10.1351/Pac198658020227 |
0.35 |
|
| 1986 |
Schwab JM, Ho CK, Li WB, Townsend CA, Salituro GM. .beta.-Hydroxydecanoyl thioester dehydrase. Complete characterization of the fate of the "suicide" substrate 3-decynoyl-NAC Journal of the American Chemical Society. 108: 5309-5316. DOI: 10.1021/Ja00277A041 |
0.304 |
|
| 1985 |
Townsend CA. The stereochemical fate of chiral-methyl valines in cephalosporin C biosynthesis. Journal of Natural Products. 48: 708-24. PMID 4078571 DOI: 10.1021/Np50041A002 |
0.349 |
|
| 1985 |
Townsend CA, Ho MF. Biosynthesis of clavulanic acid: Origin of the C3 unit Journal of the American Chemical Society. 107: 1066-1068. DOI: 10.1021/Ja00290A056 |
0.329 |
|
| 1984 |
Townsend CA, Salituro GM. Fate of [15N]-p-hydroxyphenyl)glycine in nocardicin a biosynthesis Journal of the Chemical Society, Chemical Communications. 1631-1632. DOI: 10.1039/C39840001631 |
0.304 |
|
| 1983 |
Townsend CA, Brown AM. Nocardicin A: biosynthetic experiments with amino acid precursors Journal of the American Chemical Society. 105: 913-918. DOI: 10.1021/Ja00342A046 |
0.315 |
|
| 1983 |
Townsend CA, Christensen SB. Stable isotope studies of anthraquinone intermediates in the aflatoxin pathway Tetrahedron. 39: 3575-3582. DOI: 10.1016/S0040-4020(01)88668-3 |
0.348 |
|
| 1982 |
Townsend CA, Brown AM. Nocardicin A biosynthesis: stereochemical course of monocyclic .beta.-lactam formation Journal of the American Chemical Society. 104: 1748-1750. DOI: 10.1021/Ja00370A056 |
0.312 |
|
| 1982 |
Townsend CA, Nguyen LT. Improved asymetric synthesis of (-)-3-aminonocardicinic acid and further observations of the mitsunobu reaction for β-lactam formation in seryl peptides Tetrahedron Letters. 23: 4859-4862. DOI: 10.1016/S0040-4039(00)85732-9 |
0.318 |
|
| 1981 |
Townsend CA, Nguyen LT. Asymmetric, biogenetically modeled synthesis of (-)-3-aminonocardicinic acid Journal of the American Chemical Society. 103: 4582-4583. DOI: 10.1021/Ja00405A050 |
0.32 |
|
| 1976 |
Imfeld M, Townsend CA, Arigoni D. Intact transfer of methyl groups in the biosynthesis of vitamin B 12 Journal of the Chemical Society, Chemical Communications. 541-542. DOI: 10.1039/C39760000541 |
0.573 |
|
| 1976 |
Scott A, Georgopapadakou N, Ho K, Klioze S, Lee E, Lee S, Temme, III. G, Townsend C. Additions and Corrections - Concerning the Intermediacy of Uro'gen III and of a Heptacarboxylic Uro'Gen in Corrinoid Biosynthesis Journal of the American Chemical Society. 98: 2371-2371. DOI: 10.1021/Ja00424A601 |
0.447 |
|
| 1975 |
Townsend CA, Scholl T, Arigoni D. A new synthesis of chiral acetic acid Journal of the Chemical Society, Chemical Communications. 921-922. DOI: 10.1039/C39750000921 |
0.619 |
|
| 1975 |
SCOTT AI, GEORGOPAPADAKOU N, HO KS, KLIOZE S, LEE E, LEE SL, TEMME GHI, TOWNSEND CA, ARMITAGE IM. ChemInform Abstract: CONCERNING THE INTERMEDIACY OF URO′GEN III AND OF A HEPTACARBOXYLIC URO′GEN IN CORRINOID BIOSYNTHESIS Chemischer Informationsdienst. 6: no-no. DOI: 10.1002/Chin.197530441 |
0.44 |
|
| 1974 |
Scott AI, Townsend CA, Okada K, Kajiwara M, Cushley RJ, Whitman PJ. Biosynthesis of corrins. II. Incorporation of 13C-labeled substrates in vitamins B12. Journal of the American Chemical Society. 96: 8069-80. PMID 4464318 |
0.39 |
|
| 1974 |
Scott AI, Townsend CA, Okada K, Kajiwara M. Biosynthesis of corrins. I. Experiments with 14-C porphobilinogen and 14-C uroporphyrinogens. Journal of the American Chemical Society. 96: 8054-69. PMID 4464317 |
0.382 |
|
| 1974 |
Scott A, Lee E, Townsend CA. On corrin biogenesis Bioorganic Chemistry. 3: 229-237. DOI: 10.1016/0045-2068(74)90046-7 |
0.464 |
|
| 1973 |
Scott AI, Townsend CA, Cushley RJ. Stereochemistry of methyl group insertion in corrinoid biosynthesis. Determination of carbon isotope chirality by 13C nuclear magnetic resonance. Journal of the American Chemical Society. 95: 5759-61. PMID 4733816 |
0.374 |
|
| 1973 |
Scott AI, Townsend CA, Okada K, Kajiwara M. Concerning the biosynthesis of vitamin B12. Transactions of the New York Academy of Sciences. 35: 72-9. PMID 4509732 |
0.332 |
|
| 1973 |
SCOTT AI, TOWNSEND CA, CUSHLEY RJ. ChemInform Abstract: CARBON-13 FOURIER TRANSFORM NMR PART 7, STEREOCHEMISTRY OF METHYL GROUP INSERTION IN CORRINOID BIOSYNTHESIS, DETERMINATION OF CARBON ISOTOPE CHIRALITY BY (13)C NUCLEAR MAGNETIC RESONANCE Chemischer Informationsdienst. 4: no-no. DOI: 10.1002/Chin.197344078 |
0.444 |
|
| 1972 |
Scott AI, Townsend CA, Okada K, Kajiwara M, Cushley RJ. Biosynthesis of corrinoids. Uroporphyrinogen 3 as a precrusor of vitamin B 12 . Journal of the American Chemical Society. 94: 8269-71. PMID 5079976 DOI: 10.1021/JA00778A077 |
0.336 |
|
| 1972 |
Scott AI, Townsend CA, Okada K, Kajiwara M, Whitman PJ. Biosynthesis of corrinoids. Concerning ithe origin of the methyl groups in vitamin B 12 . Journal of the American Chemical Society. 94: 8267-9. PMID 5079975 |
0.354 |
|
| Show low-probability matches. |
