Alexander Y. Rudensky - Publications

University of Washington, Seattle, Seattle, WA 
Immunology, Microbiology Biology, Virology Biology

150 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Xu K, Yin N, Peng M, Stamatiades EG, Shyu A, Li P, Zhang X, Do MH, Wang Z, Capistrano KJ, Chou C, Levine AG, Rudensky AY, Li MO. Glycolysis fuels phosphoinositide 3-kinase signaling to bolster T cell immunity. Science (New York, N.Y.). 371: 405-410. PMID 33479154 DOI: 10.1126/science.abb2683  0.4
2021 Hemmers S, Schizas M, Rudensky AY. T reg cell-intrinsic requirements for ST2 signaling in health and neuroinflammation. The Journal of Experimental Medicine. 218. PMID 33095261 DOI: 10.1084/jem.20201234  0.32
2020 Campbell C, Marchildon F, Michaels AJ, Takemoto N, van der Veeken J, Schizas M, Pritykin Y, Leslie CS, Intlekofer AM, Cohen P, Rudensky AY. FXR mediates T cell-intrinsic responses to reduced feeding during infection. Proceedings of the National Academy of Sciences of the United States of America. PMID 33318189 DOI: 10.1073/pnas.2020619117  0.32
2020 Zeis P, Lian M, Fan X, Herman JS, Hernandez DC, Gentek R, Elias S, Symowski C, Knöpper K, Peltokangas N, Friedrich C, Doucet-Ladeveze R, Kabat AM, Locksley RM, Voehringer D, ... ... Rudensky AY, et al. In Situ Maturation and Tissue Adaptation of Type 2 Innate Lymphoid Cell Progenitors. Immunity. PMID 33002412 DOI: 10.1016/j.immuni.2020.09.002  0.4
2020 Campbell C, McKenney PT, Konstantinovsky D, Isaeva OI, Schizas M, Verter J, Mai C, Jin WB, Guo CJ, Violante S, Ramos RJ, Cross JR, Kadaveru K, Hambor J, Rudensky AY. Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells. Nature. 581: 475-479. PMID 32461639 DOI: 10.1038/s41586-020-2193-0  0.32
2019 Hemmers S, Schizas M, Azizi E, Dikiy S, Zhong Y, Feng Y, Altan-Bonnet G, Rudensky AY. IL-2 production by self-reactive CD4 thymocytes scales regulatory T cell generation in the thymus. The Journal of Experimental Medicine. PMID 31434685 DOI: 10.1084/jem.20190993  0.4
2019 Yen WF, Sharma R, Cols M, Lau CM, Chaudhry A, Chowdhury P, Yewdell WT, Vaidyanathan B, Sun A, Coffre M, Pucella JN, Chen CC, Jasin M, Sun JC, Rudensky AY, et al. Distinct Requirements of CHD4 during B Cell Development and Antibody Response. Cell Reports. 27: 1472-1486.e5. PMID 31042474 DOI: 10.1016/j.celrep.2019.04.011  0.36
2018 Fan X, Moltedo B, Mendoza A, Davydov AN, Faire MB, Mazutis L, Sharma R, Pe'er D, Chudakov DM, Rudensky AY. CD49b defines functionally mature Treg cells that survey skin and vascular tissues. The Journal of Experimental Medicine. PMID 30355617 DOI: 10.1084/jem.20181442  0.4
2018 Mann M, Mehta A, Zhao JL, Lee K, Marinov GK, Garcia-Flores Y, Lu LF, Rudensky AY, Baltimore D. Author Correction: An NF-κB-microRNA regulatory network tunes macrophage inflammatory responses. Nature Communications. 9: 3338. PMID 30115909 DOI: 10.1038/s41467-018-05720-5  0.4
2018 Cho S, Lee HM, Yu IS, Choi YS, Huang HY, Hashemifar SS, Lin LL, Chen MC, Afanasiev ND, Khan AA, Lin SW, Rudensky AY, Crotty S, Lu LF. Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b. Nature Communications. 9: 2757. PMID 30013024 DOI: 10.1038/s41467-018-05196-3  0.4
2018 Campbell C, Dikiy S, Bhattarai SK, Chinen T, Matheis F, Calafiore M, Hoyos B, Hanash A, Mucida D, Bucci V, Rudensky AY. Extrathymically Generated Regulatory T Cells Establish a Niche for Intestinal Border-Dwelling Bacteria and Affect Physiologic Metabolite Balance. Immunity. PMID 29858010 DOI: 10.1016/j.immuni.2018.04.013  0.4
2018 Li K, Vorkas CK, Chaudhry A, Bell DL, Willis RA, Rudensky A, Altman JD, Glickman MS, Aubé J. Synthesis, stabilization, and characterization of the MR1 ligand precursor 5-amino-6-D-ribitylaminouracil (5-A-RU). Plos One. 13: e0191837. PMID 29401462 DOI: 10.1371/journal.pone.0191837  0.36
2017 Green JA, Arpaia N, Schizas M, Dobrin A, Rudensky AY. A nonimmune function of T cells in promoting lung tumor progression. The Journal of Experimental Medicine. PMID 29038367 DOI: 10.1084/jem.20170356  1
2017 Levine AG, Mendoza A, Hemmers S, Moltedo B, Niec RE, Schizas M, Hoyos BE, Putintseva EV, Chaudhry A, Dikiy S, Fujisawa S, Chudakov DM, Treuting PM, Rudensky AY. Corrigendum: Stability and function of regulatory T cells expressing the transcription factor T-bet. Nature. PMID 28953866 DOI: 10.1038/nature24013  0.4
2017 Yen WF, Chaudhry A, Vaidyanathan B, Yewdell WT, Pucella JN, Sharma R, Liang Y, Li K, Rudensky AY, Chaudhuri J. BRCT-domain protein BRIT1 influences class switch recombination. Proceedings of the National Academy of Sciences of the United States of America. PMID 28724724 DOI: 10.1073/pnas.1708211114  0.56
2017 Levine AG, Medoza A, Hemmers S, Moltedo B, Niec RE, Schizas M, Hoyos BE, Putintseva EV, Chaudhry A, Dikiy S, Fujisawa S, Chudakov DM, Treuting PM, Rudensky AY. Stability and function of regulatory T cells expressing the transcription factor T-bet. Nature. 546: 421-425. PMID 28607488 DOI: 10.1038/nature22360  0.4
2017 Levine AG, Hemmers S, Baptista AP, Schizas M, Faire MB, Moltedo B, Konopacki C, Schmidt-Supprian M, Germain RN, Treuting PM, Rudensky AY. Suppression of lethal autoimmunity by regulatory T cells with a single TCR specificity. The Journal of Experimental Medicine. PMID 28130403 DOI: 10.1084/jem.20161318  0.4
2017 Fontenot JD, Gavin MA, Rudensky AY. Pillars Article: Foxp3 Programs the Development and Function of CD4+CD25+ Regulatory T Cells. Nat. Immunol. 2003. 4: 330-336. Journal of Immunology (Baltimore, Md. : 1950). 198: 986-992. PMID 28115587  0.88
2016 Vaidyanathan B, Chaudhry A, Yewdell WT, Angeletti D, Yen WF, Wheatley AK, Bradfield CA, McDermott AB, Yewdell JW, Rudensky AY, Chaudhuri J. The aryl hydrocarbon receptor controls cell-fate decisions in B cells. The Journal of Experimental Medicine. PMID 28011866 DOI: 10.1084/jem.20160789  0.36
2016 Chinen T, Kannan AK, Levine AG, Fan X, Klein U, Zheng Y, Gasteiger G, Feng Y, Fontenot JD, Rudensky AY. An essential role for the IL-2 receptor in Treg cell function. Nature Immunology. PMID 27595233 DOI: 10.1038/ni.3540  0.4
2016 Fan X, Rudensky AY. Hallmarks of Tissue-Resident Lymphocytes. Cell. 164: 1198-211. PMID 26967286 DOI: 10.1016/j.cell.2016.02.048  1
2016 Cho S, Wu CJ, Yasuda T, Cruz LO, Khan AA, Lin LL, Nguyen DT, Miller M, Lee HM, Kuo ML, Broide DH, Rajewsky K, Rudensky AY, Lu LF. miR-23∼27∼24 clusters control effector T cell differentiation and function. The Journal of Experimental Medicine. PMID 26834155 DOI: 10.1083/jcb.2124OIA22  1
2015 Feng Y, van der Veeken J, Shugay M, Putintseva EV, Osmanbeyoglu HU, Dikiy S, Hoyos BE, Moltedo B, Hemmers S, Treuting P, Leslie CS, Chudakov DM, Rudensky AY. A mechanism for expansion of regulatory T-cell repertoire and its role in self-tolerance. Nature. PMID 26605529 DOI: 10.1038/nature16141  1
2015 Liu Z, Gerner MY, Van Panhuys N, Levine AG, Rudensky AY, Germain RN. Immune homeostasis enforced by co-localized effector and regulatory T cells. Nature. PMID 26605524 DOI: 10.1038/nature16169  1
2015 Arvey A, van der Veeken J, Plitas G, Rich SS, Concannon P, Rudensky AY. Genetic and epigenetic variation in the lineage specification of regulatory T cells. Elife. 4. PMID 26510014 DOI: 10.7554/eLife.07571  1
2015 Gasteiger G, Fan X, Dikiy S, Lee SY, Rudensky AY. Tissue residency of innate lymphoid cells in lymphoid and non-lymphoid organs. Science (New York, N.Y.). PMID 26472762 DOI: 10.1126/science.aac9593  0.4
2015 Paterson AM, Lovitch SB, Sage PT, Juneja VR, Lee Y, Trombley JD, Arancibia-Cárcamo CV, Sobel RA, Rudensky AY, Kuchroo VK, Freeman GJ, Sharpe AH. Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity. The Journal of Experimental Medicine. 212: 1603-21. PMID 26371185 DOI: 10.1084/jem.20141030  1
2015 Arpaia N, Green JA, Moltedo B, Arvey A, Hemmers S, Yuan S, Treuting PM, Rudensky AY. A Distinct Function of Regulatory T Cells in Tissue Protection. Cell. 162: 1078-89. PMID 26317471 DOI: 10.1016/j.cell.2015.08.021  1
2015 Lu LF, Gasteiger G, Yu IS, Chaudhry A, Hsin JP, Lu Y, Bos PD, Lin LL, Zawislak CL, Cho S, Sun JC, Leslie CS, Lin SW, Rudensky AY. A Single miRNA-mRNA Interaction Affects the Immune Response in a Context- and Cell-Type-Specific Manner. Immunity. 43: 52-64. PMID 26163372 DOI: 10.1016/j.immuni.2015.04.022  1
2015 Feng Y, Rudensky AY. DNA methylation secures CD4(+) and CD8(+) T cell lineage borders. Nature Immunology. 16: 681-3. PMID 26086134 DOI: 10.1038/ni.3207  0.4
2014 Vierstra J, Rynes E, Sandstrom R, Zhang M, Canfield T, Hansen RS, Stehling-Sun S, Sabo PJ, Byron R, Humbert R, Thurman RE, Johnson AK, Vong S, Lee K, Bates D, ... ... Rudensky A, et al. Mouse regulatory DNA landscapes reveal global principles of cis-regulatory evolution. Science (New York, N.Y.). 346: 1007-12. PMID 25411453 DOI: 10.1126/science.1246426  1
2014 Levine AG, Arvey A, Jin W, Rudensky AY. Continuous requirement for the TCR in regulatory T cell function. Nature Immunology. 15: 1070-8. PMID 25263123 DOI: 10.1038/ni.3004  1
2014 Gasteiger G, Rudensky AY. Interactions between innate and adaptive lymphocytes. Nature Reviews. Immunology. 14: 631-9. PMID 25132095 DOI: 10.1038/nri3726  0.4
2014 Feng Y, Arvey A, Chinen T, van der Veeken J, Gasteiger G, Rudensky AY. Control of the inheritance of regulatory T cell identity by a cis element in the Foxp3 locus. Cell. 158: 749-63. PMID 25126783 DOI: 10.1016/j.cell.2014.07.031  1
2014 Penaloza-MacMaster P, Kamphorst AO, Wieland A, Araki K, Iyer SS, West EE, O'Mara L, Yang S, Konieczny BT, Sharpe AH, Freeman GJ, Rudensky AY, Ahmed R. Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection. The Journal of Experimental Medicine. 211: 1905-18. PMID 25113973 DOI: 10.1084/jem.20132577  1
2014 Arvey A, van der Veeken J, Samstein RM, Feng Y, Stamatoyannopoulos JA, Rudensky AY. Inflammation-induced repression of chromatin bound by the transcription factor Foxp3 in regulatory T cells. Nature Immunology. 15: 580-7. PMID 24728351 DOI: 10.1038/ni.2868  1
2014 Ho BC, Yu IS, Lu LF, Rudensky A, Chen HY, Tsai CW, Chang YL, Wu CT, Chang LY, Shih SR, Lin SW, Lee CN, Yang PC, Yu SL. Inhibition of miR-146a prevents enterovirus-induced death by restoring the production of type I interferon. Nature Communications. 5: 3344. PMID 24561744 DOI: 10.1038/ncomms4344  1
2014 Moltedo B, Hemmers S, Rudensky AY. Regulatory T cell ablation causes acute T cell lymphopenia. Plos One. 9: e86762. PMID 24466225 DOI: 10.1371/journal.pone.0086762  1
2014 Arpaia N, Rudensky AY. Microbial metabolites control gut inflammatory responses. Proceedings of the National Academy of Sciences of the United States of America. 111: 2058-9. PMID 24434557 DOI: 10.1073/pnas.1323183111  1
2013 van der Veeken J, Arvey A, Rudensky A. Transcriptional control of regulatory T-cell differentiation. Cold Spring Harbor Symposia On Quantitative Biology. 78: 215-22. PMID 24733379 DOI: 10.1101/sqb.2013.78.020289  1
2013 Arpaia N, Campbell C, Fan X, Dikiy S, van der Veeken J, deRoos P, Liu H, Cross JR, Pfeffer K, Coffer PJ, Rudensky AY. Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation. Nature. 504: 451-5. PMID 24226773 DOI: 10.1038/nature12726  1
2013 Sakaguchi S, Vignali DA, Rudensky AY, Niec RE, Waldmann H. The plasticity and stability of regulatory T cells. Nature Reviews. Immunology. 13: 461-7. PMID 23681097 DOI: 10.1038/nri3464  1
2013 Gasteiger G, Hemmers S, Firth MA, Le Floc'h A, Huse M, Sun JC, Rudensky AY. IL-2-dependent tuning of NK cell sensitivity for target cells is controlled by regulatory T cells. The Journal of Experimental Medicine. 210: 1167-78. PMID 23650441 DOI: 10.1084/jem.20122462  0.4
2013 Gasteiger G, Hemmers S, Bos PD, Sun JC, Rudensky AY. IL-2-dependent adaptive control of NK cell homeostasis. The Journal of Experimental Medicine. 210: 1179-87. PMID 23650439 DOI: 10.1084/jem.20122571  0.4
2013 Zawislak CL, Beaulieu AM, Loeb GB, Karo J, Canner D, Bezman NA, Lanier LL, Rudensky AY, Sun JC. Stage-specific regulation of natural killer cell homeostasis and response against viral infection by microRNA-155. Proceedings of the National Academy of Sciences of the United States of America. 110: 6967-72. PMID 23572582 DOI: 10.1073/pnas.1304410110  1
2013 Chaudhry A, Rudensky AY. Control of inflammation by integration of environmental cues by regulatory T cells. The Journal of Clinical Investigation. 123: 939-44. PMID 23454755 DOI: 10.1172/JCI57175  1
2012 Loeb GB, Khan AA, Canner D, Hiatt JB, Shendure J, Darnell RB, Leslie CS, Rudensky AY. Transcriptome-wide miR-155 binding map reveals widespread noncanonical microRNA targeting. Molecular Cell. 48: 760-70. PMID 23142080 DOI: 10.1016/j.molcel.2012.10.002  1
2012 Ouyang W, Liao W, Luo CT, Yin N, Huse M, Kim MV, Peng M, Chan P, Ma Q, Mo Y, Meijer D, Zhao K, Rudensky AY, Atwal G, Zhang MQ, et al. Novel Foxo1-dependent transcriptional programs control T(reg) cell function. Nature. 491: 554-9. PMID 23135404 DOI: 10.1038/nature11581  1
2012 Samstein RM, Arvey A, Josefowicz SZ, Peng X, Reynolds A, Sandstrom R, Neph S, Sabo P, Kim JM, Liao W, Li MO, Leslie C, Stamatoyannopoulos JA, Rudensky AY. Foxp3 exploits a pre-existent enhancer landscape for regulatory T cell lineage specification. Cell. 151: 153-66. PMID 23021222 DOI: 10.1016/j.cell.2012.06.053  1
2012 Weiss JM, Bilate AM, Gobert M, Ding Y, Curotto de Lafaille MA, Parkhurst CN, Xiong H, Dolpady J, Frey AB, Ruocco MG, Yang Y, Floess S, Huehn J, Oh S, Li MO, ... ... Rudensky AY, et al. Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells. The Journal of Experimental Medicine. 209: 1723-42, S1. PMID 22966001 DOI: 10.1084/jem.20120914  1
2012 Rudra D, deRoos P, Chaudhry A, Niec RE, Arvey A, Samstein RM, Leslie C, Shaffer SA, Goodlett DR, Rudensky AY. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Nature Immunology. 13: 1010-9. PMID 22922362 DOI: 10.1038/ni.2402  1
2012 Samstein RM, Josefowicz SZ, Arvey A, Treuting PM, Rudensky AY. Extrathymic generation of regulatory T cells in placental mammals mitigates maternal-fetal conflict. Cell. 150: 29-38. PMID 22770213 DOI: 10.1016/j.cell.2012.05.031  1
2012 Darce J, Rudra D, Li L, Nishio J, Cipolletta D, Rudensky AY, Mathis D, Benoist C. An N-terminal mutation of the Foxp3 transcription factor alleviates arthritis but exacerbates diabetes. Immunity. 36: 731-41. PMID 22579475 DOI: 10.1016/j.immuni.2012.04.007  1
2012 Josefowicz SZ, Niec RE, Kim HY, Treuting P, Chinen T, Zheng Y, Umetsu DT, Rudensky AY. Extrathymically generated regulatory T cells control mucosal TH2 inflammation. Nature. 482: 395-9. PMID 22318520 DOI: 10.1038/nature10772  0.96
2012 Josefowicz SZ, Lu LF, Rudensky AY. Regulatory T cells: mechanisms of differentiation and function. Annual Review of Immunology. 30: 531-64. PMID 22224781 DOI: 10.1146/annurev.immunol.25.022106.141623  0.48
2012 Chinen T, Rudensky AY. The effects of commensal microbiota on immune cell subsets and inflammatory responses. Immunological Reviews. 245: 45-55. PMID 22168413 DOI: 10.1111/j.1600-065X.2011.01083.x  0.4
2011 Rudensky AY, Chervonsky AV. A narrow circle of mutual friends. Immunity. 34: 697-9. PMID 21616440 DOI: 10.1016/j.immuni.2011.05.008  1
2011 Chaudhry A, Samstein RM, Treuting P, Liang Y, Pils MC, Heinrich JM, Jack RS, Wunderlich FT, Brüning JC, Müller W, Rudensky AY. Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation. Immunity. 34: 566-78. PMID 21511185 DOI: 10.1016/j.immuni.2011.03.018  0.56
2011 Huber S, Gagliani N, Esplugues E, O'Connor W, Huber FJ, Chaudhry A, Kamanaka M, Kobayashi Y, Booth CJ, Rudensky AY, Roncarolo MG, Battaglia M, Flavell RA. Th17 cells express interleukin-10 receptor and are controlled by Foxp3⁻ and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner. Immunity. 34: 554-65. PMID 21511184 DOI: 10.1016/j.immuni.2011.01.020  0.36
2011 Sekiya T, Kashiwagi I, Inoue N, Morita R, Hori S, Waldmann H, Rudensky AY, Ichinose H, Metzger D, Chambon P, Yoshimura A. The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4+ T cells. Nature Communications. 2: 269. PMID 21468021 DOI: 10.1038/ncomms1272  1
2010 Rubtsov YP, Niec RE, Josefowicz S, Li L, Darce J, Mathis D, Benoist C, Rudensky AY. Stability of the regulatory T cell lineage in vivo. Science (New York, N.Y.). 329: 1667-71. PMID 20929851 DOI: 10.1126/science.1191996  1
2010 Chinen T, Volchkov PY, Chervonsky AV, Rudensky AY. A critical role for regulatory T cell-mediated control of inflammation in the absence of commensal microbiota. The Journal of Experimental Medicine. 207: 2323-30. PMID 20921284 DOI: 10.1084/jem.20101235  1
2010 Grainger JR, Smith KA, Hewitson JP, McSorley HJ, Harcus Y, Filbey KJ, Finney CA, Greenwood EJ, Knox DP, Wilson MS, Belkaid Y, Rudensky AY, Maizels RM. Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-β pathway. The Journal of Experimental Medicine. 207: 2331-41. PMID 20876311 DOI: 10.1084/jem.20101074  1
2010 Lu LF, Boldin MP, Chaudhry A, Lin LL, Taganov KD, Hanada T, Yoshimura A, Baltimore D, Rudensky AY. Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses. Cell. 142: 914-29. PMID 20850013 DOI: 10.1016/j.cell.2010.08.012  1
2010 Littman DR, Rudensky AY. Th17 and regulatory T cells in mediating and restraining inflammation. Cell. 140: 845-58. PMID 20303875 DOI: 10.1016/j.cell.2010.02.021  1
2010 Suthar MS, Ma DY, Thomas S, Lund JM, Zhang N, Daffis S, Rudensky AY, Bevan MJ, Clark EA, Kaja MK, Diamond MS, Gale M. IPS-1 is essential for the control of West Nile virus infection and immunity. Plos Pathogens. 6: e1000757. PMID 20140199 DOI: 10.1371/journal.ppat.1000757  1
2010 Zheng Y, Josefowicz S, Chaudhry A, Peng XP, Forbush K, Rudensky AY. Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate. Nature. 463: 808-12. PMID 20072126 DOI: 10.1038/nature08750  0.96
2010 Hsing LC, Kirk EA, McMillen TS, Hsiao SH, Caldwell M, Houston B, Rudensky AY, LeBoeuf RC. Roles for cathepsins S, L, and B in insulitis and diabetes in the NOD mouse. Journal of Autoimmunity. 34: 96-104. PMID 19664906 DOI: 10.1016/j.jaut.2009.07.003  1
2009 Lanteri MC, O'Brien KM, Purtha WE, Cameron MJ, Lund JM, Owen RE, Heitman JW, Custer B, Hirschkorn DF, Tobler LH, Kiely N, Prince HE, Ndhlovu LC, Nixon DF, Kamel HT, ... ... Rudensky AY, et al. Tregs control the development of symptomatic West Nile virus infection in humans and mice. The Journal of Clinical Investigation. 119: 3266-77. PMID 19855131 DOI: 10.1172/JCI39387  1
2009 Chaudhry A, Rudra D, Treuting P, Samstein RM, Liang Y, Kas A, Rudensky AY. CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner. Science (New York, N.Y.). 326: 986-91. PMID 19797626 DOI: 10.1126/science.1172702  0.56
2009 Rudra D, Egawa T, Chong MM, Treuting P, Littman DR, Rudensky AY. Runx-CBFbeta complexes control expression of the transcription factor Foxp3 in regulatory T cells. Nature Immunology. 10: 1170-7. PMID 19767756 DOI: 10.1038/ni.1795  1
2009 Josefowicz SZ, Rudensky A. Control of regulatory T cell lineage commitment and maintenance. Immunity. 30: 616-25. PMID 19464984 DOI: 10.1016/j.immuni.2009.04.009  0.48
2009 Josefowicz SZ, Wilson CB, Rudensky AY. Cutting edge: TCR stimulation is sufficient for induction of Foxp3 expression in the absence of DNA methyltransferase 1. Journal of Immunology (Baltimore, Md. : 1950). 182: 6648-52. PMID 19454658 DOI: 10.4049/jimmunol.0803320  1
2009 Bautista JL, Lio CW, Lathrop SK, Forbush K, Liang Y, Luo J, Rudensky AY, Hsieh CS. Intraclonal competition limits the fate determination of regulatory T cells in the thymus. Nature Immunology. 10: 610-7. PMID 19430476 DOI: 10.1038/ni.1739  1
2009 Weaver CT, Rudensky AY. Editorial overview: lymphocyte development. Current Opinion in Immunology. 21: 119-20. PMID 19361970 DOI: 10.1016/j.coi.2009.03.007  1
2009 Liu K, Victora GD, Schwickert TA, Guermonprez P, Meredith MM, Yao K, Chu FF, Randolph GJ, Rudensky AY, Nussenzweig M. In vivo analysis of dendritic cell development and homeostasis. Science (New York, N.Y.). 324: 392-7. PMID 19286519 DOI: 10.1126/science.1170540  1
2009 Zheng Y, Chaudhry A, Kas A, deRoos P, Kim JM, Chu TT, Corcoran L, Treuting P, Klein U, Rudensky AY. Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses. Nature. 458: 351-6. PMID 19182775 DOI: 10.1038/nature07674  0.96
2009 Lu LF, Thai TH, Calado DP, Chaudhry A, Kubo M, Tanaka K, Loeb GB, Lee H, Yoshimura A, Rajewsky K, Rudensky AY. Foxp3-Dependent MicroRNA155 Confers Competitive Fitness to Regulatory T Cells by Targeting SOCS1 Protein Immunity. 30: 80-91. PMID 19144316 DOI: 10.1016/j.immuni.2008.11.010  1
2008 Chong MM, Rasmussen JP, Rudensky AY, Rundensky AY, Littman DR. The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease. The Journal of Experimental Medicine. 205: 2005-17. PMID 18725527 DOI: 10.1084/jem.20081219  1
2008 Liston A, Lu LF, O'Carroll D, Tarakhovsky A, Rudensky AY. Dicer-dependent microRNA pathway safeguards regulatory T cell function. The Journal of Experimental Medicine. 205: 1993-2004. PMID 18725526 DOI: 10.1083/JCB1825OIA12  1
2008 Liston A, Nutsch KM, Farr AG, Lund JM, Rasmussen JP, Koni PA, Rudensky AY. Differentiation of regulatory Foxp3+ T cells in the thymic cortex. Proceedings of the National Academy of Sciences of the United States of America. 105: 11903-8. PMID 18695219 DOI: 10.1073/pnas.0801506105  1
2008 Rubtsov YP, Rasmussen JP, Chi EY, Fontenot J, Castelli L, Ye X, Treuting P, Siewe L, Roers A, Henderson WR, Muller W, Rudensky AY. Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. Immunity. 28: 546-58. PMID 18387831 DOI: 10.1016/j.immuni.2008.02.017  1
2008 Zhou L, Lopes JE, Chong MM, Ivanov II, Min R, Victora GD, Shen Y, Du J, Rubtsov YP, Rudensky AY, Ziegler SF, Littman DR. TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function. Nature. 453: 236-40. PMID 18368049 DOI: 10.1038/nature06878  1
2008 Chong MMW, Rasmussen JP, Rudensky AY, Littman DR. The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease (Journal of Experimental Medicine (2008) 205, 9 (2005-2017)) Journal of Experimental Medicine. 205: 2449. DOI: 10.1084/jem.20071219090508c  1
2007 Lu LF, Gavin MA, Rasmussen JP, Rudensky AY. G protein-coupled receptor 83 is dispensable for the development and function of regulatory T cells. Molecular and Cellular Biology. 27: 8065-72. PMID 17893329 DOI: 10.1128/MCB.01075-07  1
2007 Scott-Browne JP, Shafiani S, Tucker-Heard G, Ishida-Tsubota K, Fontenot JD, Rudensky AY, Bevan MJ, Urdahl KB. Expansion and function of Foxp3-expressing T regulatory cells during tuberculosis. The Journal of Experimental Medicine. 204: 2159-69. PMID 17709423 DOI: 10.1084/jem.20062105  1
2007 Maynard CL, Harrington LE, Janowski KM, Oliver JR, Zindl CL, Rudensky AY, Weaver CT. Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3- precursor cells in the absence of interleukin 10. Nature Immunology. 8: 931-41. PMID 17694059 DOI: 10.1038/ni1504  1
2007 Sather BD, Treuting P, Perdue N, Miazgowicz M, Fontenot JD, Rudensky AY, Campbell DJ. Altering the distribution of Foxp3(+) regulatory T cells results in tissue-specific inflammatory disease. The Journal of Experimental Medicine. 204: 1335-47. PMID 17548521 DOI: 10.1084/jem.20070081  0.88
2007 Zheng Y, Rudensky AY. Foxp3 in control of the regulatory T cell lineage. Nature Immunology. 8: 457-62. PMID 17440451 DOI: 10.1038/ni1455  0.96
2007 van der Vliet HJ, van der Vliet HJ, Koon HB, Yue SC, Uzunparmak B, Seery V, Gavin MA, Rudensky AY, Atkins MB, Balk SP, Exley MA. Effects of the administration of high-dose interleukin-2 on immunoregulatory cell subsets in patients with advanced melanoma and renal cell cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 13: 2100-8. PMID 17404092 DOI: 10.1158/1078-0432.CCR-06-1662  1
2007 Henderson WR, Chi EY, Bollinger JG, Tien YT, Ye X, Castelli L, Rubtsov YP, Singer AG, Chiang GK, Nevalainen T, Rudensky AY, Gelb MH. Importance of group X-secreted phospholipase A2 in allergen-induced airway inflammation and remodeling in a mouse asthma model. The Journal of Experimental Medicine. 204: 865-77. PMID 17403936 DOI: 10.1084/jem.20070029  1
2007 Denning TL, Granger SW, Granger S, Mucida D, Graddy R, Leclercq G, Zhang W, Honey K, Rasmussen JP, Cheroutre H, Rudensky AY, Kronenberg M. Mouse TCRalphabeta+CD8alphaalpha intraepithelial lymphocytes express genes that down-regulate their antigen reactivity and suppress immune responses. Journal of Immunology (Baltimore, Md. : 1950). 178: 4230-9. PMID 17371979 DOI: 10.4049/jimmunol.178.7.4230  1
2007 Liston A, Farr AG, Chen Z, Benoist C, Mathis D, Manley NR, Rudensky AY. Lack of Foxp3 function and expression in the thymic epithelium. The Journal of Experimental Medicine. 204: 475-80. PMID 17353370 DOI: 10.1084/jem.20062465  1
2007 Liston A, Rudensky AY. Thymic development and peripheral homeostasis of regulatory T cells. Current Opinion in Immunology. 19: 176-85. PMID 17306520 DOI: 10.1016/j.coi.2007.02.005  1
2007 Zheng Y, Josefowicz SZ, Kas A, Chu TT, Gavin MA, Rudensky AY. Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells. Nature. 445: 936-40. PMID 17237761 DOI: 10.1038/nature05563  1
2007 Williams LM, Rudensky AY. Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3. Nature Immunology. 8: 277-84. PMID 17220892 DOI: 10.1038/ni1437  1
2007 Gavin MA, Rasmussen JP, Fontenot JD, Vasta V, Manganiello VC, Beavo JA, Rudensky AY. Foxp3-dependent programme of regulatory T-cell differentiation. Nature. 445: 771-5. PMID 17220874 DOI: 10.1038/nature05543  1
2007 Kim JM, Rasmussen JP, Rudensky AY. Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nature Immunology. 8: 191-7. PMID 17136045 DOI: 10.1038/ni1428  1
2006 Kim JM, Rudensky A. The role of the transcription factor Foxp3 in the development of regulatory T cells. Immunological Reviews. 212: 86-98. PMID 16903908 DOI: 10.1111/j.0105-2896.2006.00426.x  0.32
2006 Rudensky AY, Gavin M, Zheng Y. FOXP3 and NFAT: partners in tolerance. Cell. 126: 253-6. PMID 16873058 DOI: 10.1016/j.cell.2006.07.005  1
2006 Gavin MA, Torgerson TR, Houston E, DeRoos P, Ho WY, Stray-Pedersen A, Ocheltree EL, Greenberg PD, Ochs HD, Rudensky AY. Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development. Proceedings of the National Academy of Sciences of the United States of America. 103: 6659-64. PMID 16617117 DOI: 10.1073/pnas.0509484103  1
2006 Rudensky AY, Campbell DJ. In vivo sites and cellular mechanisms of T reg cell-mediated suppression. The Journal of Experimental Medicine. 203: 489-92. PMID 16533888 DOI: 10.1084/jem.20060214  0.4
2006 Hsieh CS, Zheng Y, Liang Y, Fontenot JD, Rudensky AY. An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires. Nature Immunology. 7: 401-10. PMID 16532000 DOI: 10.1038/ni1318  0.96
2006 Rudensky A, Beers C. Lysosomal cysteine proteases and antigen presentation. Ernst Schering Research Foundation Workshop. 81-95. PMID 16329647 DOI: 10.1007/3-540-37673-9_5  0.64
2006 Fontenot JD, Rasmussen JP, Gavin MA, Rudensky AY. Erratum: A function for interleukin 2 in Foxp3-expressing regulatory T cells Nature Immunology. 7: 427-427. DOI: 10.1038/ni0406-427b  0.88
2006 Sather BD, Gyarmati D, Miazgowicz M, Fontenot JD, Rudensky AY, Campbell DJ. Su.135. Regulatory T-Cell Expression of CCR4 is Required to Prevent Cutaneous & Pulmonary Inflammation Clinical Immunology. 119: S206. DOI: 10.1016/j.clim.2006.04.562  0.88
2005 Fontenot JD, Rasmussen JP, Gavin MA, Rudensky AY. A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nature Immunology. 6: 1142-51. PMID 16227984 DOI: 10.1038/ni1263  1
2005 Fontenot JD, Dooley JL, Farr AG, Rudensky AY. Developmental regulation of Foxp3 expression during ontogeny Journal of Experimental Medicine. 202: 901-906. PMID 16203863 DOI: 10.1084/jem.20050784  1
2005 Hsing LC, Rudensky AY. The lysosomal cysteine proteases in MHC class II antigen presentation. Immunological Reviews. 207: 229-41. PMID 16181340 DOI: 10.1111/j.0105-2896.2005.00310.x  1
2005 Quezada SA, Bennett K, Blazar BR, Rudensky AY, Sakaguchi S, Noelle RJ. Analysis of the underlying cellular mechanisms of anti-CD154-induced graft tolerance: the interplay of clonal anergy and immune regulation. Journal of Immunology (Baltimore, Md. : 1950). 175: 771-9. PMID 16002673 DOI: 10.4049/jimmunol.175.2.771  1
2005 Hsieh CS, Rudensky AY. The role of TCR specificity in naturally arising CD25+ CD4+ regulatory T cell biology. Current Topics in Microbiology and Immunology. 293: 25-42. PMID 15981474 DOI: 10.1007/3-540-27702-1_2  0.56
2005 Marie JC, Letterio JJ, Gavin M, Rudensky AY. TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells. The Journal of Experimental Medicine. 201: 1061-7. PMID 15809351 DOI: 10.1084/jem.20042276  1
2005 Fontenot JD, Rudensky AY. A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3. Nature Immunology. 6: 331-7. PMID 15785758 DOI: 10.1038/ni1179  0.88
2005 Fontenot JD, Rasmussen JP, Williams LM, Dooley JL, Farr AG, Rudensky AY. Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity. 22: 329-41. PMID 15780990 DOI: 10.1016/j.immuni.2005.01.016  1
2005 Beers C, Burich A, Kleijmeer MJ, Griffith JM, Wong P, Rudensky AY. Cathepsin S controls MHC class II-mediated antigen presentation by epithelial cells in vivo. Journal of Immunology (Baltimore, Md. : 1950). 174: 1205-12. PMID 15661874 DOI: 10.4049/jimmunol.174.3.1205  1
2004 Hsieh CS, Liang Y, Tyznik AJ, Self SG, Liggitt D, Rudensky AY. Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors. Immunity. 21: 267-77. PMID 15308106 DOI: 10.1016/j.immuni.2004.07.009  1
2004 Fontenot JD, Rudensky AY. Molecular aspects of regulatory T cell development. Seminars in Immunology. 16: 73-80. PMID 15036230 DOI: 10.1016/j.smim.2003.12.002  0.88
2004 Honey K, Forbush K, Jensen PE, Rudensky AY. Effect of decreasing the affinity of the class II-associated invariant chain peptide on the MHC class II peptide repertoire in the presence or absence of H-2M. Journal of Immunology (Baltimore, Md. : 1950). 172: 4142-50. PMID 15034026 DOI: 10.4049/jimmunol.172.7.4142  0.52
2003 Itano AA, McSorley SJ, Reinhardt RL, Ehst BD, Ingulli E, Rudensky AY, Jenkins MK. Distinct dendritic cell populations sequentially present antigen to CD4 T cells and stimulate different aspects of cell-mediated immunity. Immunity. 19: 47-57. PMID 12871638 DOI: 10.1016/S1074-7613(03)00175-4  1
2003 Honey K, Rudensky AY. Lysosomal cysteine proteases regulate antigen presentation. Nature Reviews. Immunology. 3: 472-82. PMID 12776207 DOI: 10.1038/nri1110  0.52
2003 Quezada SA, Fuller B, Jarvinen LZ, Gonzalez M, Blazar BR, Rudensky AY, Strom TB, Noelle RJ. Mechanisms of donor-specific transfusion tolerance: preemptive induction of clonal T-cell exhaustion via indirect presentation. Blood. 102: 1920-6. PMID 12750162 DOI: 10.1182/blood-2003-02-0586  1
2003 Fontenot JD, Gavin MA, Rudensky AY. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nature Immunology. 4: 330-6. PMID 12612578 DOI: 10.1038/ni904  0.88
2003 Beers C, Honey K, Fink S, Forbush K, Rudensky A. Differential regulation of cathepsin S and cathepsin L in interferon gamma-treated macrophages. The Journal of Experimental Medicine. 197: 169-79. PMID 12538657 DOI: 10.1084/jem.20020978  0.64
2002 Gonzalez M, Quezada SA, Blazar BR, Panoskaltsis-Mortari A, Rudensky AY, Noelle RJ. The balance between donor T cell anergy and suppression versus lethal graft-versus-host disease is determined by host conditioning. Journal of Immunology (Baltimore, Md. : 1950). 169: 5581-9. PMID 12421935 DOI: 10.4049/jimmunol.169.10.5581  1
2002 Honey K, Benlagha K, Beers C, Forbush K, Teyton L, Kleijmeer MJ, Rudensky AY, Bendelac A. Thymocyte expression of cathepsin L is essential for NKT cell development. Nature Immunology. 3: 1069-74. PMID 12368909 DOI: 10.1038/ni844  0.64
2002 Honey K, Nakagawa T, Peters C, Rudensky A. Cathepsin L regulates CD4+ T cell selection independently of its effect on invariant chain: a role in the generation of positively selecting peptide ligands. The Journal of Experimental Medicine. 195: 1349-58. PMID 12021314 DOI: 10.1084/jem.20011904  0.52
2002 Barton GM, Beers C, deRoos P, Eastman SR, Gomez ME, Forbush KA, Rudensky AY. Positive selection of self-MHC-reactive T cells by individual peptide-MHC class II complexes. Proceedings of the National Academy of Sciences of the United States of America. 99: 6937-42. PMID 12011451 DOI: 10.1073/pnas.102645699  1
2002 Hsieh CS, deRoos P, Honey K, Beers C, Rudensky AY. A role for cathepsin L and cathepsin S in peptide generation for MHC class II presentation. Journal of Immunology (Baltimore, Md. : 1950). 168: 2618-25. PMID 11884425 DOI: 10.4049/jimmunol.168.6.2618  0.64
2002 Gavin MA, Rudensky AY. Dual TCR T cells: gaining entry into the periphery. Nature Immunology. 3: 109-10. PMID 11812982 DOI: 10.1038/ni0202-109  0.52
2001 Honey K, Rudensky A. The pIV-otal class II transactivator promoter regulates major histocompatibility complex class II expression in the thymus. The Journal of Experimental Medicine. 194: F15-8. PMID 11514611 DOI: 10.1084/jem.194.4.F15  0.52
2001 Mukherjee P, Dani A, Bhatia S, Singh N, Rudensky AY, George A, Bal V, Mayor S, Rath S. Efficient presentation of both cytosolic and endogenous transmembrane protein antigens on MHC class II is dependent on cytoplasmic proteolysis Journal of Immunology. 167: 2632-2641. PMID 11509605 DOI: 10.4049/jimmunol.167.5.2632  1
2001 Dongre AR, Kovats S, deRoos P, McCormack AL, Nakagawa T, Paharkova-Vatchkova V, Eng J, Caldwell H, Yates JR, Rudensky AY. In vivo MHC class II presentation of cytosolic proteins revealed by rapid automated tandem mass spectrometry and functional analyses. European Journal of Immunology. 31: 1485-94. PMID 11465105 DOI: 10.1002/1521-4141(200105)31:5<1485::AID-IMMU1485>3.0.CO;2-A  0.52
2001 Wong P, Barton GM, Forbush KA, Rudensky AY. Dynamic tuning of T cell reactivity by self-peptide-major histocompatibility complex ligands Journal of Experimental Medicine. 193: 1179-1187. PMID 11369789 DOI: 10.1084/jem.193.10.1179  1
2000 Wong P, Goldrath AW, Rudensky AY. Competition for specific intrathymic ligands limits positive selection in a TCR transgenic model of CD4+ T cell development. Journal of Immunology (Baltimore, Md. : 1950). 164: 6252-9. PMID 10843678 DOI: 10.4049/jimmunol.164.12.6252  0.88
1999 Barton GM, Rudensky AY. Evaluating peptide repertoires within the context of thymocyte development Seminars in Immunology. 11: 417-422. PMID 10625595 DOI: 10.1006/smim.1999.0199  1
1999 Barton GM, Rudensky AY. Requirement for diverse, low-abundance peptides in positive selection of T cells Science. 283: 67-70. PMID 9872742 DOI: 10.1126/science.283.5398.67  1
1998 Barton GM, Rudensky AY. An altered invariant chain protein with an antigenic peptide in place of CLIP forms SDS-stable complexes with class II αβ dimers and facilitates highly efficient peptide loading International Immunology. 10: 1159-1165. PMID 9723702 DOI: 10.1093/intimm/10.8.1159  1
1998 Chervonsky AV, Medzhitov RM, Denzin LK, Barlow AK, Rudensky AY, Janeway CA. Subtle conformational changes induced in major histocompatibility complex class II molecules by binding peptides. Proceedings of the National Academy of Sciences of the United States of America. 95: 10094-9. PMID 9707606 DOI: 10.1073/pnas.95.17.10094  1
1998 Farr AG, Rudensky A. Medullary thymic epithelium: a mosaic of epithelial "self"? The Journal of Experimental Medicine. 188: 1-4. PMID 9653078 DOI: 10.1084/jem.188.1.1  0.44
1998 Nakagawa T, Roth W, Wong P, Nelson A, Farr A, Deussing J, Villadangos JA, Ploegh H, Peters C, Rudensky AY. Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus. Science (New York, N.Y.). 280: 450-3. PMID 9545226 DOI: 10.1126/science.280.5362.450  0.88
1998 Liljedahl M, Winqvist O, Surh CD, Wong P, Ngo K, Teyton L, Peterson PA, Brunmark A, Rudensky AY, Fung-Leung WP, Karlsson L. Altered antigen presentation in mice lacking H2-O Immunity. 8: 233-243. PMID 9492004 DOI: 10.1016/S1074-7613(00)80475-6  1
1997 La Flamme AC, Kahn SJ, Rudensky AY, Van Voorhis WC. Trypanosoma cruzi-infected macrophages are defective in major histocompatibility complex class II antigen presentation European Journal of Immunology. 27: 3085-3094. PMID 9464791 DOI: 10.1002/eji.1830271202  1
1997 Kleijmeer MJ, Morkowski S, Griffith JM, Rudensky AY, Geuze HJ. Major histocompatibility complex class II compartments in human and mouse B lymphoblasts represent conventional endocytic compartments. The Journal of Cell Biology. 139: 639-49. PMID 9348281 DOI: 10.1083/jcb.139.3.639  1
1997 Grubin CE, Kovats S, deRoos P, Rudensky AY. Deficient positive selection of CD4 T cells in mice displaying altered repertoires of MHC class II-bound self-peptides. Immunity. 7: 197-208. PMID 9285405 DOI: 10.1016/S1074-7613(00)80523-3  0.52
1997 Kovats S, Whiteley PE, Concannon P, Rudensky AY, Blum JS. Presentation of abundant endogenous class II DR-restricted antigens by DM-negative B cell lines. European Journal of Immunology. 27: 1014-21. PMID 9130658 DOI: 10.1002/eji.1830270431  1
1996 Wong P, Rudensky AY. Phenotype and function of CD4+ T cells in mice lacking invariant chain. Journal of Immunology (Baltimore, Md. : 1950). 156: 2133-42. PMID 8690902  0.88
1996 Smiley ST, Rudensky AY, Glimcher LH, Grusby MJ. Truncation of the class II beta-chain cytoplasmic domain influences the level of class II/invariant chain-derived peptide complexes. Proceedings of the National Academy of Sciences of the United States of America. 93: 241-4. PMID 8552613 DOI: 10.1073/pnas.93.1.241  1
1994 Rudensky AY, Maric M, Eastman S, Shoemaker L, DeRoos PC, Blum JS. Intracellular assembly and transport of endogenous peptide-MHC class II complexes. Immunity. 1: 585-94. PMID 7600287 DOI: 10.1016/1074-7613(94)90048-5  1
1992 Janeway CA, Rudensky AY, Preston-Hurlburt P. Peptides bound to MHC Nature. 357: 120-120. DOI: 10.1038/357120b0  0.56
1991 Rudensky Y, Preston-Hurlburt P, Hong SC, Barlow A, Janeway CA. Sequence analysis of peptides bound to MHC class II molecules. Nature. 353: 622-7. PMID 1656276 DOI: 10.1038/353622a0  0.4
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