Michael Krangel - Publications

Immunology Duke University, Durham, NC 
Cell Biology, Microbiology Biology, Molecular Biology

30 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Loguercio S, Barajas-Mora EM, Shih HY, Krangel MS, Feeney AJ. Variable Extent of Lineage-Specificity and Developmental Stage-Specificity of Cohesin and CCCTC-Binding Factor Binding Within the Immunoglobulin and T Cell Receptor Loci. Frontiers in Immunology. 9: 425. PMID 29593713 DOI: 10.3389/fimmu.2018.00425  0.76
2016 Chen L, Zhao L, Alt FW, Krangel MS. An Ectopic CTCF Binding Element Inhibits Tcrd Rearrangement by Limiting Contact between Vδ and Dδ Gene Segments. Journal of Immunology (Baltimore, Md. : 1950). PMID 27613698 DOI: 10.4049/jimmunol.1601124  0.72
2016 Zhao L, Frock RL, Du Z, Hu J, Chen L, Krangel MS, Alt FW. Orientation-specific RAG activity in chromosomal loop domains contributes to Tcrd V(D)J recombination during T cell development. The Journal of Experimental Medicine. PMID 27526713 DOI: 10.1084/jem.20160670  0.72
2016 Chen L, Foreman DP, Sant'Angelo DB, Krangel MS. Yin Yang 1 Promotes Thymocyte Survival by Downregulating p53. Journal of Immunology (Baltimore, Md. : 1950). PMID 26843327 DOI: 10.4049/jimmunol.1501916  0.72
2016 Thornton TM, Delgado P, Chen L, Salas B, Krementsov D, Fernandez M, Vernia S, Davis RJ, Heimann R, Teuscher C, Krangel MS, Ramiro AR, Rincón M. Inactivation of nuclear GSK3β by Ser(389) phosphorylation promotes lymphocyte fitness during DNA double-strand break response. Nature Communications. 7: 10553. PMID 26822034 DOI: 10.1038/ncomms10553  0.72
2016 Rupp LJ, Chen L, Krangel MS, Bassing CH. Molecular Analysis of Mouse T Cell Receptor α and β Gene Rearrangements. Methods in Molecular Biology (Clifton, N.J.). 1323: 179-202. PMID 26294409 DOI: 10.1007/978-1-4939-2809-5_16  0.72
2015 Carico Z, Krangel MS. Chromatin Dynamics and the Development of the TCRα and TCRδ Repertoires. Advances in Immunology. 128: 307-61. PMID 26477370 DOI: 10.1016/bs.ai.2015.07.005  0.72
2015 Chen L, Carico Z, Shih HY, Krangel MS. A discrete chromatin loop in the mouse Tcra-Tcrd locus shapes the TCRδ and TCRα repertoires. Nature Immunology. 16: 1085-93. PMID 26258942 DOI: 10.1038/ni.3232  0.76
2015 Hao B, Naik AK, Watanabe A, Tanaka H, Chen L, Richards HW, Kondo M, Taniuchi I, Kohwi Y, Kohwi-Shigematsu T, Krangel MS. An anti-silencer- and SATB1-dependent chromatin hub regulates Rag1 and Rag2 gene expression during thymocyte development. The Journal of Experimental Medicine. 212: 809-24. PMID 25847946 DOI: 10.1084/jem.20142207  0.4
2015 Boudil A, Matei IR, Shih HY, Bogdanoski G, Yuan JS, Chang SG, Montpellier B, Kowalski PE, Voisin V, Bashir S, Bader GD, Krangel MS, Guidos CJ. IL-7 coordinates proliferation, differentiation and Tcra recombination during thymocyte β-selection. Nature Immunology. 16: 397-405. PMID 25729925 DOI: 10.1038/ni.3122  0.4
2015 Majumder K, Koues OI, Chan EA, Kyle KE, Horowitz JE, Yang-Iott K, Bassing CH, Taniuchi I, Krangel MS, Oltz EM. Lineage-specific compaction of Tcrb requires a chromatin barrier to protect the function of a long-range tethering element. The Journal of Experimental Medicine. 212: 107-20. PMID 25512470 DOI: 10.1084/jem.20141479  0.4
2015 Naik AK, Hawwari A, Krangel MS. Specification of Vδ and Vα usage by Tcra/Tcrd locus V gene segment promoters. Journal of Immunology (Baltimore, Md. : 1950). 194: 790-4. PMID 25472997 DOI: 10.4049/jimmunol.1402423  0.4
2014 Tubbs AT, Dorsett Y, Chan E, Helmink B, Lee BS, Hung P, George R, Bredemeyer AL, Mittal A, Pappu RV, Chowdhury D, Mosammaparast N, Krangel MS, Sleckman BP. KAP-1 promotes resection of broken DNA ends not protected by γ-H2AX and 53BP1 in G₁-phase lymphocytes. Molecular and Cellular Biology. 34: 2811-21. PMID 24842905 DOI: 10.1128/MCB.00441-14  0.4
2013 Chan EA, Teng G, Corbett E, Choudhury KR, Bassing CH, Schatz DG, Krangel MS. Peripheral subnuclear positioning suppresses Tcrb recombination and segregates Tcrb alleles from RAG2. Proceedings of the National Academy of Sciences of the United States of America. 110: E4628-37. PMID 24218622 DOI: 10.1073/pnas.1310846110  0.4
2013 Shih HY, Krangel MS. Chromatin architecture, CCCTC-binding factor, and V(D)J recombination: managing long-distance relationships at antigen receptor loci. Journal of Immunology (Baltimore, Md. : 1950). 190: 4915-21. PMID 23645930 DOI: 10.4049/jimmunol.1300218  0.76
2012 Shih HY, Verma-Gaur J, Torkamani A, Feeney AJ, Galjart N, Krangel MS. Tcra gene recombination is supported by a Tcra enhancer- and CTCF-dependent chromatin hub. Proceedings of the National Academy of Sciences of the United States of America. 109: E3493-502. PMID 23169622 DOI: 10.1073/pnas.1214131109  0.4
2011 Kondilis-Mangum HD, Shih HY, Mahowald G, Sleckman BP, Krangel MS. Regulation of TCRβ allelic exclusion by gene segment proximity and accessibility. Journal of Immunology (Baltimore, Md. : 1950). 187: 6374-81. PMID 22079986 DOI: 10.4049/jimmunol.1102611  0.76
2011 Seitan VC, Hao B, Tachibana-Konwalski K, Lavagnolli T, Mira-Bontenbal H, Brown KE, Teng G, Carroll T, Terry A, Horan K, Marks H, Adams DJ, Schatz DG, Aragon L, Fisher AG, ... Krangel MS, et al. A role for cohesin in T-cell-receptor rearrangement and thymocyte differentiation. Nature. 476: 467-71. PMID 21832993 DOI: 10.1038/nature10312  0.4
2011 Hao B, Krangel MS. Long-distance regulation of fetal V(δ) gene segment TRDV4 by the Tcrd enhancer. Journal of Immunology (Baltimore, Md. : 1950). 187: 2484-91. PMID 21784972 DOI: 10.4049/jimmunol.1100468  0.4
2011 Shih HY, Hao B, Krangel MS. Orchestrating T-cell receptor α gene assembly through changes in chromatin structure and organization. Immunologic Research. 49: 192-201. PMID 21128009 DOI: 10.1007/s12026-010-8181-y  0.76
2010 Shih HY, Krangel MS. Distinct contracted conformations of the Tcra/Tcrd locus during Tcra and Tcrd recombination. The Journal of Experimental Medicine. 207: 1835-41. PMID 20696701 DOI: 10.1084/jem.20100772  0.76
2010 Kondilis-Mangum HD, Cobb RM, Osipovich O, Srivatsan S, Oltz EM, Krangel MS. Transcription-dependent mobilization of nucleosomes at accessible TCR gene segments in vivo. Journal of Immunology (Baltimore, Md. : 1950). 184: 6970-7. PMID 20483751 DOI: 10.4049/jimmunol.0903923  0.4
2007 Roberts JL, Lauritsen JP, Cooney M, Parrott RE, Sajaroff EO, Win CM, Keller MD, Carpenter JH, Carabana J, Krangel MS, Sarzotti M, Zhong XP, Wiest DL, Buckley RH. T-B+NK+ severe combined immunodeficiency caused by complete deficiency of the CD3zeta subunit of the T-cell antigen receptor complex. Blood. 109: 3198-206. PMID 17170122 DOI: 10.1182/blood-2006-08-043166  0.4
2006 Jackson AM, Krangel MS. A role for MAPK in feedback inhibition of Tcrb recombination. Journal of Immunology (Baltimore, Md. : 1950). 176: 6824-30. PMID 16709842  1
2006 Jackson AM, Krangel MS. Turning T-cell receptor beta recombination on and off: more questions than answers. Immunological Reviews. 209: 129-41. PMID 16448539 DOI: 10.1111/j.0105-2896.2006.00342.x  1
2005 Jackson AM, Krangel MS. Allele-specific regulation of TCR beta variable gene segment chromatin structure. Journal of Immunology (Baltimore, Md. : 1950). 175: 5186-91. PMID 16210623  1
2005 Jackson A, Kondilis HD, Khor B, Sleckman BP, Krangel MS. Regulation of T cell receptor beta allelic exclusion at a level beyond accessibility. Nature Immunology. 6: 189-97. PMID 15640803 DOI: 10.1038/ni1157  0.44
2004 Osipovich O, Milley R, Meade A, Tachibana M, Shinkai Y, Krangel MS, Oltz EM. Targeted inhibition of V(D)J recombination by a histone methyltransferase. Nature Immunology. 5: 309-16. PMID 14985714 DOI: 10.1038/ni1042  0.4
2002 Sikes ML, Meade A, Tripathi R, Krangel MS, Oltz EM. Regulation of V(D)J recombination: a dominant role for promoter positioning in gene segment accessibility. Proceedings of the National Academy of Sciences of the United States of America. 99: 12309-14. PMID 12196630 DOI: 10.1073/pnas.182166699  0.4
2002 Guo J, Hawwari A, Li H, Sun Z, Mahanta SK, Littman DR, Krangel MS, He YW. Regulation of the TCRα repertoire by the survival window of CD4+CD8+ thymocytes Nature Immunology. 3: 469-476. PMID 11967541 DOI: 10.1038/ni791  0.4
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