| Year |
Citation |
Score |
| 2017 |
Gierse RM, Redeem E, Diamanti E, Wrenger C, Groves MR, Hirsch AK. DXS as a target for structure-based drug design. Future Medicinal Chemistry. 9: 1277-1294. PMID 28636418 DOI: 10.4155/Fmc-2016-0239 |
0.395 |
|
| 2017 |
Scheepstra M, Andrei SA, Unver MY, Hirsch AK, Leysen S, Ottmann C, Brunsveld L, Milroy LG. Designed Spiroketal Protein Modulation. Angewandte Chemie (International Ed. in English). PMID 28407400 DOI: 10.1002/Anie.201612504 |
0.372 |
|
| 2017 |
Liu Y, Lehn JM, Hirsch AK. Molecular Biodynamers: Dynamic Covalent Analogues of Biopolymers. Accounts of Chemical Research. PMID 28169527 DOI: 10.1021/Acs.Accounts.6B00594 |
0.468 |
|
| 2017 |
Dockerty P, Edens JG, Tol MB, Morales Angeles D, Domenech A, Liu Y, Hirsch AK, Veening JW, Scheffers DJ, Witte MD. Bicyclic enol cyclocarbamates inhibit penicillin-binding proteins. Organic & Biomolecular Chemistry. PMID 28045164 DOI: 10.1039/C6Ob01664B |
0.392 |
|
| 2016 |
Wieczorek S, Remmler D, Masini T, Kochovski Z, Hirsch AK, Boerner HG. Equipping nanocarriers specifically toward cargo: A competitive study on solubilizing related photosensitizers for photodynamic therapy. Bioconjugate Chemistry. PMID 28002941 DOI: 10.1021/Acs.Bioconjchem.6B00549 |
0.334 |
|
| 2016 |
Mondal M, Unver MY, Pal A, Bakker M, Berrier SP, Hirsch AK. Fragment-Based Drug Design Facilitated by Protein-Templated Click Chemistry: Fragment Linking and -Optimization of Inhibitors of the Aspartic Protease Endothiapepsin. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 27604032 DOI: 10.1002/Chem.201603001 |
0.371 |
|
| 2016 |
Masini T, Birkaya B, van Dijk S, Mondal M, Hekelaar J, Jäger M, Terwisscha van Scheltinga AC, Patel MS, Hirsch AK, Moman E. Furoates and thenoates inhibit pyruvate dehydrogenase kinase 2 allosterically by binding to its pyruvate regulatory site. Journal of Enzyme Inhibition and Medicinal Chemistry. 1-6. PMID 27435185 DOI: 10.1080/14756366.2016.1201812 |
0.354 |
|
| 2016 |
Mondal M, Radeva N, Fanlo-Virgós H, Otto S, Klebe G, Hirsch AK. Fragment Linking and Optimization of Inhibitors of the Aspartic Protease Endothiapepsin: Fragment-Based Drug Design Facilitated by Dynamic Combinatorial Chemistry. Angewandte Chemie (International Ed. in English). PMID 27400756 DOI: 10.1002/Anie.201603074 |
0.382 |
|
| 2015 |
Monjas L, Hirsch AK. Harnessing dynamic combinatorial chemistry in the search for new ligands for protein targets. Future Medicinal Chemistry. PMID 26510895 DOI: 10.4155/Fmc.15.146 |
0.318 |
|
| 2015 |
Masini T, Lacy B, Monjas L, Hawksley D, de Voogd AR, Illarionov B, Iqbal A, Leeper FJ, Fischer M, Kontoyianni M, Hirsch AK. Validation of a homology model of Mycobacterium tuberculosis DXS: rationalization of observed activities of thiamine derivatives as potent inhibitors of two orthologues of DXS. Organic & Biomolecular Chemistry. PMID 26411373 DOI: 10.1039/C5Ob01666E |
0.334 |
|
| 2015 |
Hartman AM, Mondal M, Radeva N, Klebe G, Hirsch AK. Structure-Based Optimization of Inhibitors of the Aspartic Protease Endothiapepsin. International Journal of Molecular Sciences. 16: 19184-94. PMID 26287174 DOI: 10.3390/Ijms160819184 |
0.372 |
|
| 2015 |
Huizing AP, Mondal M, Hirsch AK. Fighting Malaria: Structure-Guided Discovery of Nonpeptidomimetic Plasmepsin Inhibitors. Journal of Medicinal Chemistry. 58: 5151-63. PMID 25719272 DOI: 10.1021/Jm5014133 |
0.391 |
|
| 2015 |
Mondal M, Hirsch AK. Dynamic combinatorial chemistry: a tool to facilitate the identification of inhibitors for protein targets. Chemical Society Reviews. 44: 2455-88. PMID 25706945 DOI: 10.1039/C4Cs00493K |
0.349 |
|
| 2015 |
Swier LJ, Monjas L, Guskov A, de Voogd AR, Erkens GB, Slotboom DJ, Hirsch AK. Structure-based design of potent small-molecule binders to the S-component of the ECF transporter for thiamine. Chembiochem : a European Journal of Chemical Biology. 16: 819-26. PMID 25676607 DOI: 10.1002/Cbic.201402673 |
0.325 |
|
| 2015 |
Wieczorek S, Vigne S, Masini T, Ponader D, Hartmann L, Hirsch AK, Börner HG. Combinatorial screening for specific drug solubilizers with switchable release profiles. Macromolecular Bioscience. 15: 82-9. PMID 25557786 DOI: 10.1002/Mabi.201400443 |
0.32 |
|
| 2014 |
Masini T, Hirsch AK. Development of inhibitors of the 2C-methyl-D-erythritol 4-phosphate (MEP) pathway enzymes as potential anti-infective agents. Journal of Medicinal Chemistry. 57: 9740-63. PMID 25210872 DOI: 10.1021/Jm5010978 |
0.345 |
|
| 2014 |
Scheepstra M, Nieto L, Hirsch AK, Fuchs S, Leysen S, Lam CV, in het Panhuis L, van Boeckel CA, Wienk H, Boelens R, Ottmann C, Milroy LG, Brunsveld L. A natural-product switch for a dynamic protein interface. Angewandte Chemie (International Ed. in English). 53: 6443-8. PMID 24821627 DOI: 10.1002/Anie.201403773 |
0.348 |
|
| 2014 |
Mondal M, Radeva N, Köster H, Park A, Potamitis C, Zervou M, Klebe G, Hirsch AK. Structure-based design of inhibitors of the aspartic protease endothiapepsin by exploiting dynamic combinatorial chemistry. Angewandte Chemie (International Ed. in English). 53: 3259-63. PMID 24532096 DOI: 10.1002/Anie.201309682 |
0.393 |
|
| 2014 |
Hirsch AK, Reutenauer P, Le Moignan M, Ulrich S, Boul PJ, Harrowfield JM, Jarowski PD, Lehn JM. Theoretical and structural analysis of long C-C bonds in the adducts of polycyanoethylene and anthracene derivatives and their connection to the reversibility of Diels-Alder reactions. Chemistry (Weinheim An Der Bergstrasse, Germany). 20: 1073-80. PMID 24339005 DOI: 10.1002/Chem.201303276 |
0.394 |
|
| 2013 |
Wieczorek S, Krause E, Hackbarth S, Röder B, Hirsch AK, Börner HG. Exploiting specific interactions toward next-generation polymeric drug transporters. Journal of the American Chemical Society. 135: 1711-4. PMID 23305453 DOI: 10.1021/Ja311895Z |
0.309 |
|
| 2012 |
van der Meer JY, Hirsch AK. The isoprenoid-precursor dependence of Plasmodium spp. Natural Product Reports. 29: 721-8. PMID 22555616 DOI: 10.1039/C2Np20013A |
0.359 |
|
| 2012 |
Hirsch AK, Buhler E, Lehn JM. Biodynamers: self-organization-driven formation of doubly dynamic proteoids. Journal of the American Chemical Society. 134: 4177-83. PMID 22300496 DOI: 10.1021/Ja2099134 |
0.426 |
|
| 2008 |
Crane CM, Hirsch AK, Alphey MS, Sgraja T, Lauw S, Illarionova V, Rohdich F, Eisenreich W, Hunter WN, Bacher A, Diederich F. Synthesis and characterization of cytidine derivatives that inhibit the kinase IspE of the non-mevalonate pathway for isoprenoid biosynthesis. Chemmedchem. 3: 91-101. PMID 18033714 DOI: 10.1002/Cmdc.200700208 |
0.496 |
|
| 2007 |
Hirsch A, Fischer F, Diederich F. Molekulare Erkennung von Phosphaten in der Strukturbiologie Angewandte Chemie. 119: 342-357. DOI: 10.1002/Ange.200603420 |
0.517 |
|
| 2006 |
Sneddon HF, van den Heuvel A, Hirsch AK, Booth RA, Shaw DM, Gaunt MJ, Ley SV. Double conjugate addition of dithiols to propargylic carbonyl systems to generate protected 1,3-dicarbonyl compounds. The Journal of Organic Chemistry. 71: 2715-25. PMID 16555825 DOI: 10.1021/Jo052514S |
0.385 |
|
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