Wen-Hwa Lee - Publications

Biomedical Sciences - Ph.D. University of California, Irvine, Irvine, CA 
Molecular Biology, Biochemistry, Microbiology Biology, Genetics

53 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Hsu JL, Chou JW, Chen TF, Hsu JT, Su FY, Lan JL, Wu PC, Hu CM, Lee EY, Lee WH. Glutathione peroxidase 8 negatively regulates caspase-4/11 to protect against colitis. Embo Molecular Medicine. e9386. PMID 31782617 DOI: 10.15252/emmm.201809386  0.48
2019 Hsieh YL, Su FY, Tsai LK, Huang CC, Ko YL, Su LW, Chen KY, Shih HM, Hu CM, Lee WH. NPGPx-Mediated Adaptation to Oxidative Stress Protects Motor Neurons from Degeneration in Aging by Directly Modulating O-GlcNAcase. Cell Reports. 29: 2134-2143.e7. PMID 31747588 DOI: 10.1016/j.celrep.2019.10.053  0.48
2019 Hu CM, Tien SC, Hsieh PK, Jeng YM, Chang MC, Chang YT, Chen YJ, Chen YJ, Lee EYP, Lee WH. High Glucose Triggers Nucleotide Imbalance through O-GlcNAcylation of Key Enzymes and Induces KRAS Mutation in Pancreatic Cells. Cell Metabolism. PMID 30853214 DOI: 10.1016/j.cmet.2019.02.005  0.48
2018 Chen YL, Hu CM, Hsu JT, Chang CC, Huang TY, Chiang PH, Chen WY, Chang YT, Chang MC, Tien YW, Lee EY, Jeng YM, Lee WH. Cellular 5-hydroxylmethylcytosine content determines tumorigenic potential and prognosis of pancreatic ductal adenocarcinoma. American Journal of Cancer Research. 8: 2548-2563. PMID 30662811  0.48
2018 Peng HY, Chang MC, Hu CM, Yang HI, Lee WH, Chang YT. Thrombospondin-2 is a Highly Specific Diagnostic Marker and is Associated with Prognosis in Pancreatic Cancer. Annals of Surgical Oncology. PMID 30569296 DOI: 10.1245/s10434-018-07109-6  0.48
2017 Huang SC, Wei PC, Hwang-Verslues WW, Kuo WH, Jeng YM, Hu CM, Shew JY, Huang CS, Chang KJ, Lee EY, Lee WH. TGF-β1 secreted by Tregs in lymph nodes promotes breast cancer malignancy via up-regulation of IL-17RB. Embo Molecular Medicine. PMID 28993429 DOI: 10.15252/emmm.201606914  0.48
2017 Huang CK, Chang PH, Kuo WH, Chen CL, Jeng YM, Chang KJ, Shew JY, Hu CM, Lee WH. Adipocytes promote malignant growth of breast tumours with monocarboxylate transporter 2 expression via β-hydroxybutyrate. Nature Communications. 8: 14706. PMID 28281525 DOI: 10.1038/ncomms14706  0.48
2015 Zhu J, Chen H, Guo XE, Qiu XL, Hu CM, Chamberlin AR, Lee WH. Synthesis, molecular modeling, and biological evaluation of novel RAD51 inhibitors. European Journal of Medicinal Chemistry. 96: 196-208. PMID 25874343 DOI: 10.1016/j.ejmech.2015.04.021  0.68
2015 Hu CM, Zhu J, Guo XE, Chen W, Qiu XL, Ngo B, Chien R, Wang YV, Tsai CY, Wu G, Kim Y, Lopez R, Chamberlin AR, Lee EY, Lee WH. Novel small molecules disrupting Hec1/Nek2 interaction ablate tumor progression by triggering Nek2 degradation through a death-trap mechanism. Oncogene. 34: 1220-30. PMID 24662830 DOI: 10.1038/onc.2014.67  0.68
2014 Wang DD, Guo XE, Modrek AS, Chen CF, Chen PL, Lee WH. Helicase SUV3, polynucleotide phosphorylase, and mitochondrial polyadenylation polymerase form a transient complex to modulate mitochondrial mRNA polyadenylated tail lengths in response to energetic changes. The Journal of Biological Chemistry. 289: 16727-35. PMID 24770417 DOI: 10.1074/jbc.M113.536540  0.68
2014 Guo XE, Ngo B, Modrek AS, Lee WH. Targeting tumor suppressor networks for cancer therapeutics. Current Drug Targets. 15: 2-16. PMID 24387338  0.68
2013 Ngo B, Hu CM, Guo XE, Ngo B, Wei R, Zhu J, Lee WH. Complementary interhelical interactions between three buried Glu-Lys pairs within three heptad repeats are essential for Hec1-Nuf2 heterodimerization and mitotic progression. The Journal of Biological Chemistry. 288: 34403-13. PMID 24129578 DOI: 10.1074/jbc.M113.490524  0.68
2013 He S, Ni D, Ma B, Lee JH, Zhang T, Ghozalli I, Pirooz SD, Zhao Z, Bharatham N, Li B, Oh S, Lee WH, Takahashi Y, Wang HG, Minassian A, et al. PtdIns(3)P-bound UVRAG coordinates Golgi-ER retrograde and Atg9 transport by differential interactions with the ER tether and the beclin 1 complex. Nature Cell Biology. 15: 1206-19. PMID 24056303 DOI: 10.1038/ncb2848  0.68
2013 Hwang-Verslues WW, Chang PH, Jeng YM, Kuo WH, Chiang PH, Chang YC, Hsieh TH, Su FY, Lin LC, Abbondante S, Yang CY, Hsu HM, Yu JC, Chang KJ, Shew JY, ... ... Lee WH, et al. Loss of corepressor PER2 under hypoxia up-regulates OCT1-mediated EMT gene expression and enhances tumor malignancy. Proceedings of the National Academy of Sciences of the United States of America. 110: 12331-6. PMID 23836662 DOI: 10.1073/pnas.1222684110  0.68
2013 Zhu J, Zhou L, Wu G, Konig H, Lin X, Li G, Qiu XL, Chen CF, Hu CM, Goldblatt E, Bhatia R, Chamberlin AR, Chen PL, Lee WH. A novel small molecule RAD51 inactivator overcomes imatinib-resistance in chronic myeloid leukaemia. Embo Molecular Medicine. 5: 353-65. PMID 23341130 DOI: 10.1002/emmm.201201760  0.68
2013 Wei PC, Wang ZF, Lo WT, Su MI, Shew JY, Chang TC, Lee WH. A cis-element with mixed G-quadruplex structure of NPGPx promoter is essential for nucleolin-mediated transactivation on non-targeting siRNA stress. Nucleic Acids Research. 41: 1533-43. PMID 23241391 DOI: 10.1093/nar/gks1232  0.68
2013 Chen PL, Chen CF, Chen Y, Guo XE, Huang CK, Shew JY, Reddick RL, Wallace DC, Lee WH. Mitochondrial genome instability resulting from SUV3 haploinsufficiency leads to tumorigenesis and shortened lifespan. Oncogene. 32: 1193-201. PMID 22562243 DOI: 10.1038/onc.2012.120  0.68
2012 Wei PC, Hsieh YH, Su MI, Jiang X, Hsu PH, Lo WT, Weng JY, Jeng YM, Wang JM, Chen PL, Chang YC, Lee KF, Tsai MD, Shew JY, Lee WH. Loss of the oxidative stress sensor NPGPx compromises GRP78 chaperone activity and induces systemic disease. Molecular Cell. 48: 747-59. PMID 23123197 DOI: 10.1016/j.molcel.2012.10.007  0.68
2012 Chang PH, Hwang-Verslues WW, Chang YC, Chen CC, Hsiao M, Jeng YM, Chang KJ, Lee EY, Shew JY, Lee WH. Activation of Robo1 signaling of breast cancer cells by Slit2 from stromal fibroblast restrains tumorigenesis via blocking PI3K/Akt/β-catenin pathway. Cancer Research. 72: 4652-61. PMID 22826604 DOI: 10.1158/0008-5472.CAN-12-0877  0.68
2012 Wei PC, Lo WT, Su MI, Shew JY, Lee WH. Non-targeting siRNA induces NPGPx expression to cooperate with exoribonuclease XRN2 for releasing the stress. Nucleic Acids Research. 40: 323-32. PMID 21908404 DOI: 10.1093/nar/gkr714  0.68
2011 Guo XE, Chen CF, Wang DD, Modrek AS, Phan VH, Lee WH, Chen PL. Uncoupling the roles of the SUV3 helicase in maintenance of mitochondrial genome stability and RNA degradation. The Journal of Biological Chemistry. 286: 38783-94. PMID 21911497 DOI: 10.1074/jbc.M111.257956  0.68
2011 Wei R, Ngo B, Wu G, Lee WH. Phosphorylation of the Ndc80 complex protein, HEC1, by Nek2 kinase modulates chromosome alignment and signaling of the spindle assembly checkpoint. Molecular Biology of the Cell. 22: 3584-94. PMID 21832156 DOI: 10.1091/mbc.E11-01-0012  0.68
2011 Tsai CY, Ngo B, Tapadia A, Hsu PH, Wu G, Lee WH. Aurora-A phosphorylates Augmin complex component Hice1 protein at an N-terminal serine/threonine cluster to modulate its microtubule binding activity during spindle assembly. The Journal of Biological Chemistry. 286: 30097-106. PMID 21705324 DOI: 10.1074/jbc.M111.266767  0.68
2011 Furuta S, Jeng YM, Zhou L, Huang L, Kuhn I, Bissell MJ, Lee WH. IL-25 causes apoptosis of IL-25R-expressing breast cancer cells without toxicity to nonmalignant cells. Science Translational Medicine. 3: 78ra31. PMID 21490275 DOI: 10.1126/scitranslmed.3001374  0.68
2009 Hwang-Verslues WW, Kuo WH, Chang PH, Pan CC, Wang HH, Tsai ST, Jeng YM, Shew JY, Kung JT, Chen CH, Lee EY, Chang KJ, Lee WH. Multiple lineages of human breast cancer stem/progenitor cells identified by profiling with stem cell markers. Plos One. 4: e8377. PMID 20027313 DOI: 10.1371/journal.pone.0008377  0.68
2009 Wu G, Wei R, Cheng E, Ngo B, Lee WH. Hec1 contributes to mitotic centrosomal microtubule growth for proper spindle assembly through interaction with Hice1. Molecular Biology of the Cell. 20: 4686-95. PMID 19776357 DOI: 10.1091/mbc.E08-11-1123  0.68
2009 Wang DD, Shu Z, Lieser SA, Chen PL, Lee WH. Human mitochondrial SUV3 and polynucleotide phosphorylase form a 330-kDa heteropentamer to cooperatively degrade double-stranded RNA with a 3'-to-5' directionality. The Journal of Biological Chemistry. 284: 20812-21. PMID 19509288 DOI: 10.1074/jbc.M109.009605  0.68
2009 Qiu XL, Li G, Wu G, Zhu J, Zhou L, Chen PL, Chamberlin AR, Lee WH. Synthesis and biological evaluation of a series of novel inhibitor of Nek2/Hec1 analogues. Journal of Medicinal Chemistry. 52: 1757-67. PMID 19243176 DOI: 10.1021/jm8015969  0.68
2009 Qiu XL, Zhu J, Wu G, Lee WH, Chamberlin AR. Stereoselective synthesis of chiral IBR2 analogues. The Journal of Organic Chemistry. 74: 2018-27. PMID 19191556 DOI: 10.1021/jo802607f  0.48
2008 Hwang-Verslues WW, Chang KJ, Lee EY, Lee WH. Breast cancer stem cells and tumor suppressor genes. Journal of the Formosan Medical Association = Taiwan Yi Zhi. 107: 751-66. PMID 18926942 DOI: 10.1016/S0929-6646(08)60188-6  0.68
2008 Wu G, Qiu XL, Zhou L, Zhu J, Chamberlin R, Lau J, Chen PL, Lee WH. Small molecule targeting the Hec1/Nek2 mitotic pathway suppresses tumor cell growth in culture and in animal. Cancer Research. 68: 8393-9. PMID 18922912 DOI: 10.1158/0008-5472.CAN-08-1915  0.48
2008 Khidr L, Wu G, Davila A, Procaccio V, Wallace D, Lee WH. Role of SUV3 helicase in maintaining mitochondrial homeostasis in human cells. The Journal of Biological Chemistry. 283: 27064-73. PMID 18678873 DOI: 10.1074/jbc.M802991200  0.4
2008 Wu G, Lin YT, Wei R, Chen Y, Shan Z, Lee WH. Hice1, a novel microtubule-associated protein required for maintenance of spindle integrity and chromosomal stability in human cells. Molecular and Cellular Biology. 28: 3652-62. PMID 18362163 DOI: 10.1128/MCB.01923-07  0.48
2007 Jeng YM, Cai-Ng S, Li A, Furuta S, Chew H, Chen PL, Lee EY, Lee WH. Brca1 heterozygous mice have shortened life span and are prone to ovarian tumorigenesis with haploinsufficiency upon ionizing irradiation. Oncogene. 26: 6160-6. PMID 17420720 DOI: 10.1038/sj.onc.1210451  0.36
2006 Wu G, Lee WH. CtIP, a multivalent adaptor connecting transcriptional regulation, checkpoint control and tumor suppression. Cell Cycle (Georgetown, Tex.). 5: 1592-6. PMID 16880746 DOI: 10.4161/cc.5.15.3127  0.4
2006 Furuta S, Wang JM, Wei S, Jeng YM, Jiang X, Gu B, Chen PL, Lee EY, Lee WH. Removal of BRCA1/CtIP/ZBRK1 repressor complex on ANG1 promoter leads to accelerated mammary tumor growth contributed by prominent vasculature. Cancer Cell. 10: 13-24. PMID 16843262 DOI: 10.1016/j.ccr.2006.05.022  0.36
2005 Furuta S, Jiang X, Gu B, Cheng E, Chen PL, Lee WH. Depletion of BRCA1 impairs differentiation but enhances proliferation of mammary epithelial cells. Proceedings of the National Academy of Sciences of the United States of America. 102: 9176-81. PMID 15967981 DOI: 10.1073/pnas.0503793102  0.36
2005 Chen PL, Liu F, Cai S, Lin X, Li A, Chen Y, Gu B, Lee EY, Lee WH. Inactivation of CtIP leads to early embryonic lethality mediated by G1 restraint and to tumorigenesis by haploid insufficiency. Molecular and Cellular Biology. 25: 3535-42. PMID 15831459 DOI: 10.1128/MCB.25.9.3535-3542.2005  0.36
2004 Beischlag TV, Taylor RT, Rose DW, Yoon D, Chen Y, Lee WH, Rosenfeld MG, Hankinson O. Recruitment of thyroid hormone receptor/retinoblastoma-interacting protein 230 by the aryl hydrocarbon receptor nuclear translocator is required for the transcriptional response to both dioxin and hypoxia. The Journal of Biological Chemistry. 279: 54620-8. PMID 15485806 DOI: 10.1074/jbc.M410456200  0.68
2004 Utomo A, Jiang X, Furuta S, Yun J, Levin DS, Wang YC, Desai KV, Green JE, Chen PL, Lee WH. Identification of a novel putative non-selenocysteine containing phospholipid hydroperoxide glutathione peroxidase (NPGPx) essential for alleviating oxidative stress generated from polyunsaturated fatty acids in breast cancer cells. The Journal of Biological Chemistry. 279: 43522-9. PMID 15294905 DOI: 10.1074/jbc.M407141200  0.68
2004 Ting NS, Lee WH. The DNA double-strand break response pathway: becoming more BRCAish than ever. Dna Repair. 3: 935-44. PMID 15279779 DOI: 10.1016/j.dnarep.2004.03.026  0.68
2004 Lin SC, Lee KF, Nikitin AY, Hilsenbeck SG, Cardiff RD, Li A, Kang KW, Frank SA, Lee WH, Lee EY. Somatic mutation of p53 leads to estrogen receptor alpha-positive and -negative mouse mammary tumors with high frequency of metastasis. Cancer Research. 64: 3525-32. PMID 15150107 DOI: 10.1158/0008-5472.CAN-03-3524  0.68
2004 Shu Z, Vijayakumar S, Chen CF, Chen PL, Lee WH. Purified human SUV3p exhibits multiple-substrate unwinding activity upon conformational change. Biochemistry. 43: 4781-90. PMID 15096047 DOI: 10.1021/bi0356449  0.36
2003 Lin HR, Ting NS, Qin J, Lee WH. M phase-specific phosphorylation of BRCA2 by Polo-like kinase 1 correlates with the dissociation of the BRCA2-P/CAF complex. The Journal of Biological Chemistry. 278: 35979-87. PMID 12815053 DOI: 10.1074/jbc.M210659200  0.68
2003 Wu G, Jiang X, Lee WH, Chen PL. Assembly of functional ALT-associated promyelocytic leukemia bodies requires Nijmegen Breakage Syndrome 1. Cancer Research. 63: 2589-95. PMID 12750284  0.4
2003 Sharp ZD, Lee WH, Nikitin AY, Flesken-Nikitin A, Ikeno Y, Reddick R, Richardson AG, Nelson JF. Minimal effects of dietary restriction on neuroendocrine carcinogenesis in Rb+/- mice. Carcinogenesis. 24: 179-83. PMID 12584165 DOI: 10.1093/carcin/24.2.179  0.68
2002 Chen Y, Riley DJ, Zheng L, Chen PL, Lee WH. Phosphorylation of the mitotic regulator protein Hec1 by Nek2 kinase is essential for faithful chromosome segregation Journal of Biological Chemistry. 277: 49408-49416. PMID 12386167 DOI: 10.1074/jbc.M207069200  0.68
2002 Nikitin AY, Liu CY, Flesken-Nikitin A, Chen CF, Chen PL, Lee WH. Cell lineage-specific effects associated with multiple deficiencies of tumor susceptibility genes in Msh2(-/-)Rb(+/-) mice. Cancer Research. 62: 5134-8. PMID 12234974  0.36
2002 Yang H, Jeffrey PD, Miller J, Kinnucan E, Sun Y, Thomä NH, Zheng N, Chen PL, Lee WH, Pavletich NP. BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure Science. 297: 1837-1848. PMID 12228710 DOI: 10.1126/science.297.5588.1837  0.68
2002 Zhong Q, Boyer TG, Chen PL, Lee WH. Deficient nonhomologous end-joining activity in cell-free extracts from Brca1-null fibroblasts. Cancer Research. 62: 3966-70. PMID 12124328  0.36
2002 Peng H, Zheng L, Lee WH, Rux JJ, Rauscher FJ. A common DNA-binding site for SZF1 and the BRCA1-associated zinc finger protein, ZBRK1. Cancer Research. 62: 3773-81. PMID 12097288  0.68
2002 Zhong Q, Chen CF, Chen PL, Lee WH. BRCA1 facilitates microhomology-mediated end joining of DNA double strand breaks. The Journal of Biological Chemistry. 277: 28641-7. PMID 12039951 DOI: 10.1074/jbc.M200748200  0.36
2002 Zheng L, Flesken-Nikitin A, Chen PL, Lee WH. Deficiency of Retinoblastoma gene in mouse embryonic stem cells leads to genetic instability. Cancer Research. 62: 2498-502. PMID 11980640  0.36
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