Christian L. Lorson - Publications

University of Missouri - Columbia, Columbia, MO, United States 
Microbiology Biology, Neuroscience Biology, Molecular Biology, Genetics

60 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Shababi M, Smith CE, Kacher M, Alrawi Z, Villalón E, Davis D, Bryda EC, Lorson CL. Development of a novel severe mouse model of spinal muscular atrophy with respiratory distress type 1: FVB-nmd. Biochemical and Biophysical Research Communications. PMID 31604525 DOI: 10.1016/J.Bbrc.2019.10.032  0.64
2019 Kaifer KA, Villalón E, O'Brien BS, Sison SL, Smith CE, Simon ME, Marquez J, O'Day S, Hopkins AE, Neff R, Rindt H, Ebert AD, Lorson CL. AAV9-Mediated Delivery of miR-23a Reduces Disease Severity in Smn2B-/SMA Model Mice. Human Molecular Genetics. PMID 31211843 DOI: 10.1093/Hmg/Ddz142  0.36
2018 Shababi M, Villalón E, Kaifer KA, DeMarco V, Lorson CL. A Direct Comparison of IV and ICV Delivery Methods for Gene Replacement Therapy in a Mouse Model of SMARD1. Molecular Therapy. Methods & Clinical Development. 10: 348-360. PMID 30202772 DOI: 10.1016/J.Omtm.2018.08.005  0.64
2017 Villalón E, Shababi M, Kline R, Lorson ZC, Florea KM, Lorson CL. Selective vulnerability in neuronal populations in nmd/SMARD1 mice. Human Molecular Genetics. PMID 29272405 DOI: 10.1093/hmg/ddx434  0.64
2017 Rindt H, Tom CM, Lorson CL, Mattis VB. Optimization of trans-Splicing for Huntington's Disease RNA Therapy. Frontiers in Neuroscience. 11: 544. PMID 29066943 DOI: 10.3389/Fnins.2017.00544  0.76
2016 Shababi M, Feng Z, Villalon E, Sibigtroth CM, Osman EY, Miller MR, Williams-Simon PA, Lombardi A, Sass TH, Atkinson AK, Garcia ML, Ko CP, Lorson CL. Rescue of a Mouse Model of Spinal Muscular Atrophy with Respiratory Distress type 1 (SMARD1) by AAV9-IGHMBP2 is Dose Dependent. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 26860981 DOI: 10.1038/Mt.2016.33  0.64
2015 Rindt H, Feng Z, Mazzasette C, Glascock JJ, Valdivia D, Pyles N, Crawford TO, Swoboda KJ, Patitucci TN, Ebert AD, Sumner CJ, Ko CP, Lorson CL. Astrocytes influence the severity of spinal muscular atrophy. Human Molecular Genetics. 24: 4094-102. PMID 25911676 DOI: 10.1093/Hmg/Ddv148  0.36
2015 Seng CO, Magee C, Young PJ, Lorson CL, Allen JP. The SMN structure reveals its crucial role in snRNP assembly. Human Molecular Genetics. 24: 2138-46. PMID 25561692 DOI: 10.1093/Hmg/Ddu734  0.36
2014 Osman EY, Miller MR, Robbins KL, Lombardi AM, Atkinson AK, Brehm AJ, Lorson CL. Morpholino antisense oligonucleotides targeting intronic repressor Element1 improve phenotype in SMA mouse models. Human Molecular Genetics. 23: 4832-45. PMID 24781211 DOI: 10.1093/Hmg/Ddu198  0.36
2014 Robbins KL, Glascock JJ, Osman EY, Miller MR, Lorson CL. Defining the therapeutic window in a severe animal model of spinal muscular atrophy. Human Molecular Genetics. 23: 4559-68. PMID 24722206 DOI: 10.1093/Hmg/Ddu169  0.36
2014 Shababi M, Lorson CL, Rudnik-Schöneborn SS. Spinal muscular atrophy: a motor neuron disorder or a multi-organ disease? Journal of Anatomy. 224: 15-28. PMID 23876144 DOI: 10.1111/Joa.12083  0.64
2013 Cherry JJ, Osman EY, Evans MC, Choi S, Xing X, Cuny GD, Glicksman MA, Lorson CL, Androphy EJ. Enhancement of SMN protein levels in a mouse model of spinal muscular atrophy using novel drug-like compounds. Embo Molecular Medicine. 5: 1035-50. PMID 23740718 DOI: 10.1002/Emmm.201202305  0.36
2013 Taylor AS, Glascock JJ, Rose FF, Lutz C, Lorson CL. Restoration of SMN to Emx-1 expressing cortical neurons is not sufficient to provide benefit to a severe mouse model of Spinal Muscular Atrophy. Transgenic Research. 22: 1029-36. PMID 23512182 DOI: 10.1007/S11248-013-9702-Y  0.36
2013 Cobb MS, Rose FF, Rindt H, Glascock JJ, Shababi M, Miller MR, Osman EY, Yen PF, Garcia ML, Martin BR, Wetz MJ, Mazzasette C, Feng Z, Ko CP, Lorson CL. Development and characterization of an SMN2-based intermediate mouse model of Spinal Muscular Atrophy. Human Molecular Genetics. 22: 1843-55. PMID 23390132 DOI: 10.1093/Hmg/Ddt037  0.36
2012 Mattis VB, Tom Chang CW, Lorson CL. Analysis of a read-through promoting compound in a severe mouse model of spinal muscular atrophy. Neuroscience Letters. 525: 72-5. PMID 22819971 DOI: 10.1016/J.Neulet.2012.07.024  0.76
2012 Rindt H, Yen PF, Thebeau CN, Peterson TS, Weisman GA, Lorson CL. Replacement of huntingtin exon 1 by trans-splicing. Cellular and Molecular Life Sciences : Cmls. 69: 4191-204. PMID 22814437 DOI: 10.1007/S00018-012-1083-5  0.36
2012 Shababi M, Habibi J, Ma L, Glascock JJ, Sowers JR, Lorson CL. Partial restoration of cardio-vascular defects in a rescued severe model of spinal muscular atrophy. Journal of Molecular and Cellular Cardiology. 52: 1074-82. PMID 22285962 DOI: 10.1016/J.Yjmcc.2012.01.005  0.64
2012 Glascock JJ, Shababi M, Wetz MJ, Krogman MM, Lorson CL. Direct central nervous system delivery provides enhanced protection following vector mediated gene replacement in a severe model of spinal muscular atrophy. Biochemical and Biophysical Research Communications. 417: 376-81. PMID 22172949 DOI: 10.1016/J.Bbrc.2011.11.121  0.64
2012 Rindt H, Buckley DM, Vale SM, Krogman M, Rose FF, Garcia ML, Lorson CL. Transgenic inactivation of murine myostatin does not decrease the severity of disease in a model of Spinal Muscular Atrophy. Neuromuscular Disorders : Nmd. 22: 277-85. PMID 22079083 DOI: 10.1016/J.Nmd.2011.10.012  0.36
2012 Glascock JJ, Osman EY, Wetz MJ, Krogman MM, Shababi M, Lorson CL. Decreasing disease severity in symptomatic, Smn(-/-);SMN2(+/+), spinal muscular atrophy mice following scAAV9-SMN delivery. Human Gene Therapy. 23: 330-5. PMID 22029744 DOI: 10.1089/Hum.2011.166  0.64
2012 Shababi M, Lorson CL. Optimization of SMN trans-splicing through the analysis of SMN introns. Journal of Molecular Neuroscience : Mn. 46: 459-69. PMID 21826391 DOI: 10.1007/S12031-011-9614-3  0.64
2011 Glascock JJ, Osman EY, Coady TH, Rose FF, Shababi M, Lorson CL. Delivery of therapeutic agents through intracerebroventricular (ICV) and intravenous (IV) injection in mice. Journal of Visualized Experiments : Jove. PMID 21988897 DOI: 10.3791/2968  0.64
2011 Dale JM, Shen H, Barry DM, Garcia VB, Rose FF, Lorson CL, Garcia ML. The spinal muscular atrophy mouse model, SMAΔ7, displays altered axonal transport without global neurofilament alterations. Acta Neuropathologica. 122: 331-41. PMID 21681521 DOI: 10.1007/S00401-011-0848-5  0.36
2011 Lorson MA, Spate LD, Samuel MS, Murphy CN, Lorson CL, Prather RS, Wells KD. Disruption of the Survival Motor Neuron (SMN) gene in pigs using ssDNA. Transgenic Research. 20: 1293-304. PMID 21350916 DOI: 10.1007/S11248-011-9496-8  0.36
2011 Peter CJ, Evans M, Thayanithy V, Taniguchi-Ishigaki N, Bach I, Kolpak A, Bassell GJ, Rossoll W, Lorson CL, Bao ZZ, Androphy EJ. The COPI vesicle complex binds and moves with survival motor neuron within axons. Human Molecular Genetics. 20: 1701-11. PMID 21300694 DOI: 10.1093/Hmg/Ddr046  0.36
2011 Shababi M, Glascock J, Lorson CL. Combination of SMN trans-splicing and a neurotrophic factor increases the life span and body mass in a severe model of spinal muscular atrophy. Human Gene Therapy. 22: 135-44. PMID 20804424 DOI: 10.1089/Hum.2010.114  0.64
2010 Shababi M, Mattis VB, Lorson CL. Therapeutics that directly increase SMN expression to treat spinal muscular atrophy. Drug News & Perspectives. 23: 475-82. PMID 21031163 DOI: 10.1358/Dnp.2010.23.8.1507295  0.76
2010 Shababi M, Habibi J, Yang HT, Vale SM, Sewell WA, Lorson CL. Cardiac defects contribute to the pathology of spinal muscular atrophy models. Human Molecular Genetics. 19: 4059-71. PMID 20696672 DOI: 10.1093/Hmg/Ddq329  0.64
2010 Lorson CL, Rindt H, Shababi M. Spinal muscular atrophy: mechanisms and therapeutic strategies. Human Molecular Genetics. 19: R111-8. PMID 20392710 DOI: 10.1093/Hmg/Ddq147  0.64
2010 Butchbach ME, Rose FF, Rhoades S, Marston J, McCrone JT, Sinnott R, Lorson CL. Effect of diet on the survival and phenotype of a mouse model for spinal muscular atrophy. Biochemical and Biophysical Research Communications. 391: 835-40. PMID 19945425 DOI: 10.1016/J.Bbrc.2009.11.148  0.44
2009 Mattis VB, Fosso MY, Chang CW, Lorson CL. Subcutaneous administration of TC007 reduces disease severity in an animal model of SMA. Bmc Neuroscience. 10: 142. PMID 19948047 DOI: 10.1186/1471-2202-10-142  0.76
2009 Le Roy F, Charton K, Lorson CL, Richard I. RNA-targeting approaches for neuromuscular diseases. Trends in Molecular Medicine. 15: 580-91. PMID 19906562 DOI: 10.1016/J.Molmed.2009.10.005  0.36
2009 Mattis VB, Ebert AD, Fosso MY, Chang CW, Lorson CL. Delivery of a read-through inducing compound, TC007, lessens the severity of a spinal muscular atrophy animal model. Human Molecular Genetics. 18: 3906-13. PMID 19625298 DOI: 10.1093/Hmg/Ddp333  0.36
2009 Ebert AD, Yu J, Rose FF, Mattis VB, Lorson CL, Thomson JA, Svendsen CN. Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature. 457: 277-80. PMID 19098894 DOI: 10.1038/Nature07677  0.36
2009 Rose FF, Mattis VB, Rindt H, Lorson CL. Delivery of recombinant follistatin lessens disease severity in a mouse model of spinal muscular atrophy. Human Molecular Genetics. 18: 997-1005. PMID 19074460 DOI: 10.1093/Hmg/Ddn426  0.76
2008 Coady TH, Baughan TD, Shababi M, Passini MA, Lorson CL. Development of a single vector system that enhances trans-splicing of SMN2 transcripts. Plos One. 3: e3468. PMID 18941511 DOI: 10.1371/Journal.Pone.0003468  0.64
2008 Mattis VB, Butchbach ME, Lorson CL. Detection of human survival motor neuron (SMN) protein in mice containing the SMN2 transgene: applicability to preclinical therapy development for spinal muscular atrophy. Journal of Neuroscience Methods. 175: 36-43. PMID 18771690 DOI: 10.1016/J.Jneumeth.2008.07.024  0.76
2008 Rose FF, Meehan PW, Coady TH, Garcia VB, Garcia ML, Lorson CL. The Wallerian degeneration slow (Wld(s)) gene does not attenuate disease in a mouse model of spinal muscular atrophy. Biochemical and Biophysical Research Communications. 375: 119-23. PMID 18680723 DOI: 10.1016/J.Bbrc.2008.07.130  0.36
2008 Lorson MA, Dickson AM, Shaw DJ, Todd AG, Young EC, Morse R, Wolstencroft C, Lorson CL, Young PJ. Identification and characterisation of a nuclear localisation signal in the SMN associated protein, Gemin4. Biochemical and Biophysical Research Communications. 375: 33-7. PMID 18675250 DOI: 10.1016/J.Bbrc.2008.07.113  0.36
2008 Mattis VB, Bowerman M, Kothary R, Lorson CL. A SMNDelta7 read-through product confers functionality to the SMNDelta7 protein. Neuroscience Letters. 442: 54-8. PMID 18601974 DOI: 10.1016/J.Neulet.2008.06.059  0.36
2008 Sakla MS, Lorson CL. Induction of full-length survival motor neuron by polyphenol botanical compounds. Human Genetics. 122: 635-43. PMID 17962980 DOI: 10.1007/S00439-007-0441-0  0.36
2008 Novoyatleva T, Heinrich B, Tang Y, Benderska N, Butchbach ME, Lorson CL, Lorson MA, Ben-Dov C, Fehlbaum P, Bracco L, Burghes AH, Bollen M, Stamm S. Protein phosphatase 1 binds to the RNA recognition motif of several splicing factors and regulates alternative pre-mRNA processing. Human Molecular Genetics. 17: 52-70. PMID 17913700 DOI: 10.1093/Hmg/Ddm284  0.44
2007 Coady TH, Shababi M, Tullis GE, Lorson CL. Restoration of SMN function: delivery of a trans-splicing RNA re-directs SMN2 pre-mRNA splicing. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 1471-8. PMID 17551501 DOI: 10.1038/Sj.Mt.6300222  0.64
2006 Carrel TL, McWhorter ML, Workman E, Zhang H, Wolstencroft EC, Lorson C, Bassell GJ, Burghes AH, Beattie CE. Survival motor neuron function in motor axons is independent of functions required for small nuclear ribonucleoprotein biogenesis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 11014-22. PMID 17065443 DOI: 10.1523/Jneurosci.1637-06.2006  0.36
2006 Mattis VB, Rai R, Wang J, Chang CW, Coady T, Lorson CL. Novel aminoglycosides increase SMN levels in spinal muscular atrophy fibroblasts. Human Genetics. 120: 589-601. PMID 16951947 DOI: 10.1007/S00439-006-0245-7  0.76
2006 Baughan T, Shababi M, Coady TH, Dickson AM, Tullis GE, Lorson CL. Stimulating full-length SMN2 expression by delivering bifunctional RNAs via a viral vector. Molecular Therapy : the Journal of the American Society of Gene Therapy. 14: 54-62. PMID 16580882 DOI: 10.1016/J.Ymthe.2006.01.012  0.36
2005 Wolstencroft EC, Mattis V, Bajer AA, Young PJ, Lorson CL. A non-sequence-specific requirement for SMN protein activity: the role of aminoglycosides in inducing elevated SMN protein levels. Human Molecular Genetics. 14: 1199-210. PMID 15790598 DOI: 10.1093/Hmg/Ddi131  0.36
2005 Young PJ, Newman A, Jensen KT, Burger LR, Pintel DJ, Lorson CL. Minute virus of mice small non-structural protein NS2 localizes within, but is not required for the formation of, Smn-associated autonomous parvovirus-associated replication bodies. The Journal of General Virology. 86: 1009-14. PMID 15784894 DOI: 10.1099/Vir.0.80564-0  0.36
2004 Masson JF, Barnhart M, Battaglia TM, Morris GE, Nieman RA, Young PJ, Lorson CL, Booksh KS. Monitoring of recombinant survival motor neuron protein using fiber-optic surface plasmon resonance. The Analyst. 129: 855-9. PMID 15343403 DOI: 10.1039/B403885A  0.36
2004 Francis JW, Figueiredo D, vanderSpek JC, Ayala LM, Kim YS, Remington MP, Young PJ, Lorson CL, Ikebe S, Fishman PS, Brown RH. A survival motor neuron:tetanus toxin fragment C fusion protein for the targeted delivery of SMN protein to neurons. Brain Research. 995: 84-96. PMID 14644474 DOI: 10.1016/J.Brainres.2003.09.063  0.36
2003 Monani UR, Pastore MT, Gavrilina TO, Jablonka S, Le TT, Andreassi C, DiCocco JM, Lorson C, Androphy EJ, Sendtner M, Podell M, Burghes AH. A transgene carrying an A2G missense mutation in the SMN gene modulates phenotypic severity in mice with severe (type I) spinal muscular atrophy. The Journal of Cell Biology. 160: 41-52. PMID 12515823 DOI: 10.1083/Jcb.200208079  0.36
2002 Wehner KA, Ayala L, Kim Y, Young PJ, Hosler BA, Lorson CL, Baserga SJ, Francis JW. Survival motor neuron protein in the nucleolus of mammalian neurons. Brain Research. 945: 160-73. PMID 12126878 DOI: 10.1016/S0006-8993(02)02750-6  0.36
2002 Young PJ, Jensen KT, Burger LR, Pintel DJ, Lorson CL. Minute virus of mice small nonstructural protein NS2 interacts and colocalizes with the Smn protein. Journal of Virology. 76: 6364-9. PMID 12021369 DOI: 10.1128/Jvi.76.12.6364-6369.2002  0.36
2002 Young PJ, Jensen KT, Burger LR, Pintel DJ, Lorson CL. Minute virus of mice NS1 interacts with the SMN protein, and they colocalize in novel nuclear bodies induced by parvovirus infection. Journal of Virology. 76: 3892-904. PMID 11907229 DOI: 10.1128/Jvi.76.8.3892-3904.2002  0.36
2002 Young PJ, DiDonato CJ, Hu D, Kothary R, Androphy EJ, Lorson CL. SRp30c-dependent stimulation of survival motor neuron (SMN) exon 7 inclusion is facilitated by a direct interaction with hTra2 beta 1. Human Molecular Genetics. 11: 577-87. PMID 11875052 DOI: 10.1093/Hmg/11.5.577  0.36
2001 DiDonato CJ, Lorson CL, De Repentigny Y, Simard L, Chartrand C, Androphy EJ, Kothary R. Regulation of murine survival motor neuron (Smn) protein levels by modifying Smn exon 7 splicing. Human Molecular Genetics. 10: 2727-36. PMID 11726560 DOI: 10.1093/Hmg/10.23.2727  0.36
1999 Monani UR, Lorson CL, Parsons DW, Prior TW, Androphy EJ, Burghes AHM, McPherson JD. A single nucleotide difference that alters splicing patterns distinguishes the SMA gene SMN1 from the copy gene SMN2 Human Molecular Genetics. 8: 1177-1183. PMID 10369862 DOI: 10.1093/Hmg/8.7.1177  0.36
1998 Lorson C, Pearson J, Burger L, Pintel DJ. An SP1-binding site and TATA element are sufficient to support full transactivation by proximally bound NS1 protein of minute virus of mice Virology. 240: 326-337. PMID 9454706 DOI: 10.1006/Viro.1997.8940  0.36
1997 Lorson C, Pintel DJ. Characterization of the minute virus of mice P38 core promoter elements Journal of Virology. 71: 6568-6575. PMID 9261378 DOI: 10.1128/Jvi.71.9.6568-6575.1997  0.36
1996 Lorson C, Burger LR, Mouw M, Pintel DJ. Efficient transactivation of the minute virus of mice P38 promoter requires upstream binding of NS1 Journal of Virology. 70: 834-842. PMID 8551622 DOI: 10.1128/Jvi.70.2.834-842.1996  0.36
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