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Xiaohui Wang - Publications

Affiliations: 
University of Colorado, Boulder, Boulder, CO, United States 
Area:
opioid, pain, TLRs, neuroinflammation, transmembrane protein
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38 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Gao J, Lin C, Zhang C, Zhang X, Wang Y, Xu H, Zhang T, Li H, Wang H, Wang X. Exploring the Function of (+)-Naltrexone Precursors: Their Activity as TLR4 Antagonists and Potential in Treating Morphine Addiction. Journal of Medicinal Chemistry. PMID 38306598 DOI: 10.1021/acs.jmedchem.3c02316  0.324
2023 Wu S, Zhang C, Wang Y, Li P, Du X, Wang X. Dissecting the species-specific recognition of Neoseptin 3 by TLR4/MD2 molecular dynamics simulations. Physical Chemistry Chemical Physics : Pccp. 25: 13012-13018. PMID 37102696 DOI: 10.1039/d3cp00949a  0.304
2023 Kornilov FD, Shabalkina AV, Lin C, Volynsky PE, Kot EF, Kayushin AL, Lushpa VA, Goncharuk MV, Arseniev AS, Goncharuk SA, Wang X, Mineev KS. The architecture of transmembrane and cytoplasmic juxtamembrane regions of Toll-like receptors. Nature Communications. 14: 1503. PMID 36932058 DOI: 10.1038/s41467-023-37042-6  0.313
2022 Wang X, Lin C, Wu S, Zhang T, Wang Y, Jiang Y, Wang X. Cannabidivarin alleviates neuroinflammation by targeting TLR4 co-receptor MD2 and improves morphine-mediated analgesia. Frontiers in Immunology. 13: 929222. PMID 36032146 DOI: 10.3389/fimmu.2022.929222  0.371
2022 Zhang T, Lin C, Wu S, Jin S, Li X, Peng Y, Wang X. ACT001 Inhibits TLR4 Signaling by Targeting Co-Receptor MD2 and Attenuates Neuropathic Pain. Frontiers in Immunology. 13: 873054. PMID 35757727 DOI: 10.3389/fimmu.2022.873054  0.337
2022 Wu S, Lin C, Zhang T, Zhang B, Jin Y, Wang H, Li H, Wang Y, Wang X. Pentamidine Alleviates Inflammation and Lipopolysaccharide-Induced Sepsis by Inhibiting TLR4 Activation Targeting MD2. Frontiers in Pharmacology. 13: 835081. PMID 35281916 DOI: 10.3389/fphar.2022.835081  0.357
2020 Kot EF, Wang Y, Goncharuk SA, Zhang B, Arseniev AS, Wang X, Mineev KS. Oligomerization analysis as a tool to elucidate the mechanism of EBV latent membrane protein 1 inhibition by pentamidine. Biochimica Et Biophysica Acta. Biomembranes. 183380. PMID 32497549 DOI: 10.1016/J.Bbamem.2020.183380  0.304
2020 Wang Y, Zhang S, Li H, Wang H, Zhang T, Hutchinson MR, Yin H, Wang X. Small-Molecule Modulators of Toll-like Receptors. Accounts of Chemical Research. PMID 32233400 DOI: 10.1021/Acs.Accounts.9B00631  0.7
2020 Zhang X, Wang Y, Wang H, Li H, Zhang T, Peng Y, Wang X. Exploring methamphetamine non-enantioselectively targeting Toll-like receptor 4/myeloid differentiation protein 2 by in silico simulations and wet-lab techniques. Journal of Chemical Information and Modeling. PMID 31935095 DOI: 10.1021/Acs.Jcim.9B01040  0.411
2019 Peng Y, Zhang X, Zhang T, Grace PM, Li H, Wang Y, Li H, Chen H, Watkins LR, Hutchinson MR, Yin H, Wang X. Lovastatin inhibits Toll-like receptor 4 signaling in microglia by targeting its co-receptor myeloid differentiation protein 2 and attenuates neuropathic pain. Brain, Behavior, and Immunity. PMID 31542403 DOI: 10.1016/J.Bbi.2019.09.013  0.618
2019 Wang X, Northcutt AL, Cochran TA, Zhang X, Fabisiak TJ, Haas ME, Amat J, Li H, Rice KC, Maier S, Bachtell RK, Hutchinson MR, Watkins LR. Methamphetamine activates Toll-like receptor 4 to induce central immune signaling within the ventral tegmental area and contributes to extracellular dopamine increase in the nucleus accumbens shell. Acs Chemical Neuroscience. PMID 31282647 DOI: 10.1021/Acschemneuro.9B00225  0.397
2019 Zhang X, Peng Y, Grace PM, Metcalf MD, Kwilasz AJ, Wang Y, Zhang T, Wu S, Selfridge BR, Portoghese PS, Rice KC, Watkins LR, Hutchinson MR, Wang X. Stereochemistry and innate immune recognition: (+)-norbinaltorphimine targets myeloid differentiation protein 2 and inhibits toll-like receptor 4 signaling. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201900173RRR. PMID 31162938 DOI: 10.1096/Fj.201900173Rrr  0.403
2018 Grace PM, Wang X, Strand KA, Baratta MV, Zhang Y, Galer EL, Yin H, Maier SF, Watkins LR. DREADDed microglia in pain: Implications for spinal inflammatory signaling in male rats. Experimental Neurology. PMID 29530713 DOI: 10.1016/J.Expneurol.2018.03.005  0.557
2018 Zhang X, Cui F, Chen H, Zhang T, Yang K, Wang Y, Jiang Z, Rice KC, Watkins LR, Hutchinson MR, Li Y, Peng Y, Wang X. Dissecting the Innate Immune Recognition of Opioid Inactive Isomer (+)-Naltrexone Derived Toll-like Receptor 4 (TLR4) Antagonists. Journal of Chemical Information and Modeling. PMID 29518316 DOI: 10.1021/Acs.Jcim.7B00717  0.417
2017 Wang X. Pharmacological characterization of the opioid inactive isomers (+)-naltrexone and (+)-naloxone as toll-like receptor 4 antagonists Drug and Alcohol Dependence. 171. DOI: 10.1016/J.Drugalcdep.2016.08.580  0.319
2015 Wang X, Zhang Y, Peng Y, Hutchinson MR, Rice KC, Yin H, Watkins LR. Pharmacological characterization of the opioid inactive isomers (+)-naltrexone and (+)-naloxone as Toll-like receptor 4 antagonists. British Journal of Pharmacology. PMID 26603732 DOI: 10.1111/Bph.13394  0.592
2015 Bachtell R, Hutchinson MR, Wang X, Rice KC, Maier SF, Watkins LR. Targeting the Toll of Drug Abuse: The Translational Potential of Toll-Like Receptor 4. Cns & Neurological Disorders Drug Targets. 14: 692-9. PMID 26022268 DOI: 10.2174/1871527314666150529132503  0.368
2015 Selfridge BR, Wang X, Zhang Y, Yin H, Grace PM, Watkins LR, Jacobson AE, Rice KC. Structure-Activity Relationships of (+)-Naltrexone-Inspired Toll-like Receptor 4 (TLR4) Antagonists. Journal of Medicinal Chemistry. 58: 5038-52. PMID 26010811 DOI: 10.1021/Acs.Jmedchem.5B00426  0.61
2015 Wang X, Wang X, Feng Y, Zhu M, Yin H, Guo Q, Meng X. A two-photon fluorescent probe for detecting endogenous hypochlorite in living cells. Dalton Transactions (Cambridge, England : 2003). 44: 6613-9. PMID 25757874 DOI: 10.1039/C5Dt00012B  0.5
2015 Northcutt AL, Hutchinson MR, Wang X, Baratta MV, Hiranita T, Cochran TA, Pomrenze MB, Galer EL, Kopajtic TA, Li CM, Amat J, Larson G, Cooper DC, Huang Y, O'Neill CE, et al. DAT isn't all that: cocaine reward and reinforcement require Toll-like receptor 4 signaling. Molecular Psychiatry. PMID 25644383 DOI: 10.1038/Mp.2014.177  0.5
2015 Smith C, Wang X, Yin H. Caspases come together over LPS. Trends in Immunology. 36: 59-61. PMID 25573609 DOI: 10.1016/J.It.2014.12.007  0.55
2015 Yang H, Chen YZ, Zhang Y, Wang X, Zhao X, Godfroy JI, Liang Q, Zhang M, Zhang T, Yuan Q, Ann Royal M, Driscoll M, Xia NS, Yin H, Xue D. A lysine-rich motif in the phosphatidylserine receptor PSR-1 mediates recognition and removal of apoptotic cells. Nature Communications. 6: 5717. PMID 25564762 DOI: 10.1038/Ncomms6717  0.558
2015 Grace P, Wang X, Urban D, Baratta M, Galer E, Strand K, Zhang Y, Yin H, Roth B, Maier S, Watkins L. Selective manipulation of spinal microglia by chemogenetics: Implications for allodynia and inflammatory signaling Brain, Behavior, and Immunity. 49: e7. DOI: 10.1016/J.Bbi.2015.06.045  0.56
2014 Grace PM, Ramos KM, Rodgers KM, Wang X, Hutchinson MR, Lewis MT, Morgan KN, Kroll JL, Taylor FR, Strand KA, Zhang Y, Berkelhammer D, Huey MG, Greene LI, Cochran TA, et al. Activation of adult rat CNS endothelial cells by opioid-induced toll-like receptor 4 (TLR4) signaling induces proinflammatory, biochemical, morphological, and behavioral sequelae. Neuroscience. 280: 299-317. PMID 25241065 DOI: 10.1016/J.Neuroscience.2014.09.020  0.613
2014 Watkins LR, Wang X, Mustafa S, Hutchinson MR. In vivo veritas: (+)-Naltrexone's actions define translational importance: A letter in response to Skolnick et al. 'Translational potential of naloxone and naltrexone as TLR4 antagonists'. Trends in Pharmacological Sciences. 35: 432-3. PMID 25109571 DOI: 10.1016/J.Tips.2014.07.002  0.313
2013 Wang X, Grace PM, Pham MN, Cheng K, Strand KA, Smith C, Li J, Watkins LR, Yin H. Rifampin inhibits Toll-like receptor 4 signaling by targeting myeloid differentiation protein 2 and attenuates neuropathic pain. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 2713-22. PMID 23568774 DOI: 10.1096/Fj.12-222992  0.688
2013 Li J, Wang X, Zhang F, Yin H. Toll-like receptors as therapeutic targets for autoimmune connective tissue diseases. Pharmacology & Therapeutics. 138: 441-51. PMID 23531543 DOI: 10.1016/J.Pharmthera.2013.03.003  0.613
2013 Wang X, Smith C, Yin H. Targeting Toll-like receptors with small molecule agents. Chemical Society Reviews. 42: 4859-66. PMID 23503527 DOI: 10.1039/C3Cs60039D  0.628
2012 Wang X, Fiorini Z, Smith C, Zhang Y, Li J, Watkins LR, Yin H. Repositioning antimicrobial agent pentamidine as a disruptor of the lateral interactions of transmembrane domain 5 of EBV latent membrane protein 1. Plos One. 7: e47703. PMID 23094078 DOI: 10.1371/Journal.Pone.0047703  0.55
2012 Zhang S, Cheng K, Wang X, Yin H. Selection, synthesis, and anti-inflammatory evaluation of the arylidene malonate derivatives as TLR4 signaling inhibitors. Bioorganic & Medicinal Chemistry. 20: 6073-9. PMID 22985959 DOI: 10.1016/J.Bmc.2012.08.022  0.724
2012 Cheng K, Wang X, Zhang S, Yin H. Discovery of small-molecule inhibitors of the TLR1/TLR2 complex. Angewandte Chemie (International Ed. in English). 51: 12246-9. PMID 22969053 DOI: 10.1002/Anie.201204910  0.737
2012 Hutchinson MR, Northcutt AL, Hiranita T, Wang X, Lewis SS, Thomas J, van Steeg K, Kopajtic TA, Loram LC, Sfregola C, Galer E, Miles NE, Bland ST, Amat J, Rozeske RR, et al. Opioid activation of toll-like receptor 4 contributes to drug reinforcement. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 11187-200. PMID 22895704 DOI: 10.1523/Jneurosci.0684-12.2012  0.591
2012 Wang X, Saludes JP, Zhao TX, Csakai A, Fiorini Z, Chavez SA, Li J, Lee GI, Varga K, Yin H. Targeting the lateral interactions of transmembrane domain 5 of Epstein-Barr virus latent membrane protein 1. Biochimica Et Biophysica Acta. 1818: 2282-9. PMID 22609737 DOI: 10.1016/J.Bbamem.2012.05.013  0.727
2012 Wang X, Loram LC, Ramos K, de Jesus AJ, Thomas J, Cheng K, Reddy A, Somogyi AA, Hutchinson MR, Watkins LR, Yin H. Morphine activates neuroinflammation in a manner parallel to endotoxin. Proceedings of the National Academy of Sciences of the United States of America. 109: 6325-30. PMID 22474354 DOI: 10.1073/Pnas.1200130109  0.727
2012 Lee G, Sammond DW, Joce C, Takeshita R, McQuate SE, Ghosh N, Martin JM, Wang X, Zhao TX, Saludes JP, Csakai A, Fiorini Z, Chavez SA, Li J, Varga K, et al. Investigation of homo-oligomeric interface and binding hotspot of Latent membrane protein-1 (LMP-1) of Epstein-Barr virus (EBV) Rapid Communication in Photoscience. 1: 58-58. DOI: 10.5857/Rcp.2012.1.2.058  0.685
2012 Cheng K, Wang X, Zhang S, Yin H. Inside Back Cover: Discovery of Small‐Molecule Inhibitors of the TLR1/TLR2 Complex (Angew. Chem. Int. Ed. 49/2012) Angewandte Chemie. 51: 12375-12375. DOI: 10.1002/Anie.201208674  0.715
2012 Cheng K, Wang X, Zhang S, Yin H. Innenrücktitelbild: Discovery of Small-Molecule Inhibitors of the TLR1/TLR2 Complex (Angew. Chem. 49/2012) Angewandte Chemie. 124: 12543-12543. DOI: 10.1002/Ange.201208674  0.716
2011 Cheng K, Wang X, Yin H. Small-molecule inhibitors of the TLR3/dsRNA complex. Journal of the American Chemical Society. 133: 3764-7. PMID 21355588 DOI: 10.1021/Ja111312H  0.69
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