Richard M. Locksley - Publications

Biomedical Sciences University of California, San Francisco, San Francisco, CA 
Immunology, Microbiology Biology, Cell Biology

222 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 O'Keefe RN, Carli ALE, Baloyan D, Chisanga D, Shi W, Afshar-Sterle S, Eissmann MF, Poh AR, Pal B, Seillet C, Locksley RM, Ernst M, Buchert M. A tuft cell - ILC2 signaling circuit provides therapeutic targets to inhibit gastric metaplasia and tumor development. Nature Communications. 14: 6872. PMID 37898600 DOI: 10.1038/s41467-023-42215-4  0.351
2023 Sbierski-Kind J, Cautivo KM, Wagner JC, Dahlgren MW, Nilsson J, Krasilnikov M, Mroz NM, Lizama CO, Gan AL, Matatia PR, Taruselli MT, Chang AA, Caryotakis S, O'Leary CE, Kotas M, ... ... Locksley RM, et al. Group 2 innate lymphoid cells constrain type 3/17 lymphocytes in shared stromal niches to restrict liver fibrosis. Biorxiv : the Preprint Server For Biology. PMID 37163060 DOI: 10.1101/2023.04.26.537913  0.422
2023 Molofsky AB, Locksley RM. The ins and outs of innate and adaptive type 2 immunity. Immunity. 56: 704-722. PMID 37044061 DOI: 10.1016/j.immuni.2023.03.014  0.32
2022 Ricardo-Gonzalez RR, Kotas ME, O'Leary CE, Singh K, Damsky W, Liao C, Arouge E, Tenvooren I, Marquez DM, Schroeder AW, Cohen JN, Fassett MS, Lee J, Daniel SG, Bittinger K, ... ... Locksley RM, et al. Innate type 2 immunity controls hair follicle commensalism by Demodex mites. Immunity. PMID 36044899 DOI: 10.1016/j.immuni.2022.08.001  0.432
2022 Kotas ME, Moore CM, Gurrola Ii JG, Pletcher SD, Goldberg AN, Alvarez R, Yamato S, Bratcher PE, Shaughnessy CA, Zeitlin PL, Zhang IH, Li Y, Montgomery MT, Lee K, Cope EK, ... Locksley RM, et al. IL-13-programmed airway tuft cells produce PGE2, which promotes CFTR-dependent mucociliary function. Jci Insight. PMID 35608904 DOI: 10.1172/jci.insight.159832  0.437
2022 O'Leary CE, Sbierski-Kind J, Kotas ME, Wagner JC, Liang HE, Schroeder AW, de Tenorio JC, von Moltke J, Ricardo-Gonzalez RR, Eckalbar WL, Molofsky AB, Schneider C, Locksley RM. Bile acid-sensitive tuft cells regulate biliary neutrophil influx. Science Immunology. 7: eabj1080. PMID 35245089 DOI: 10.1126/sciimmunol.abj1080  0.717
2022 Cautivo KM, Matatia PR, Lizama CO, Mroz NM, Dahlgren MW, Yu X, Sbierski-Kind J, Taruselli MT, Brooks JF, Wade-Vallance A, Caryotakis SE, Chang AA, Liang HE, Zikherman J, Locksley RM, et al. Interferon gamma constrains type 2 lymphocyte niche boundaries during mixed inflammation. Immunity. 55: 254-271.e7. PMID 35139352 DOI: 10.1016/j.immuni.2021.12.014  0.358
2021 Kotas ME, Mroz NM, Koga S, Liang HE, Schroeder AW, Ricardo-Gonzalez RR, Schneider C, Locksley RM. CISH constrains the tuft-ILC2 circuit to set epithelial and immune tone. Mucosal Immunology. PMID 34290377 DOI: 10.1038/s41385-021-00430-6  0.377
2021 Kotas ME, Dion J, Van Dyken S, Ricardo-Gonzalez RR, Danel CJ, Taillé C, Mouthon L, Locksley RM, Terrier B. A role for IL-33-activated ILC2s in eosinophilic vasculitis. Jci Insight. PMID 33974563 DOI: 10.1172/jci.insight.143366  0.394
2021 Kastenschmidt JM, Coulis G, Farahat PK, Pham P, Rios R, Cristal TT, Mannaa AH, Ayer RE, Yahia R, Deshpande AA, Hughes BS, Savage AK, Giesige CR, Harper SQ, Locksley RM, et al. A stromal progenitor and ILC2 niche promotes muscle eosinophilia and fibrosis-associated gene expression. Cell Reports. 35: 108997. PMID 33852849 DOI: 10.1016/j.celrep.2021.108997  0.32
2021 O'Leary CE, Feng X, Cortez VS, Locksley RM, Schneider C. Interrogating the Small Intestine Tuft Cell-ILC2 Circuit Using In Vivo Manipulations. Current Protocols. 1: e77. PMID 33740294 DOI: 10.1002/cpz1.77  0.342
2021 Bielecki P, Riesenfeld SJ, Hütter JC, Torlai Triglia E, Kowalczyk MS, Ricardo-Gonzalez RR, Lian M, Amezcua Vesely MC, Kroehling L, Xu H, Slyper M, Muus C, Ludwig LS, Christian E, Tao L, ... ... Locksley RM, et al. Skin-resident innate lymphoid cells converge on a pathogenic effector state. Nature. PMID 33536623 DOI: 10.1038/s41586-021-03188-w  0.382
2020 Ricardo-Gonzalez RR, Schneider C, Liao C, Lee J, Liang HE, Locksley RM. Tissue-specific pathways extrude activated ILC2s to disseminate type 2 immunity. The Journal of Experimental Medicine. 217. PMID 32031571 DOI: 10.1084/Jem.20191172  0.363
2019 Molofsky AB, Locksley RM. Tissue immunity broadcasts near and far. Nature Reviews. Immunology. PMID 31748703 DOI: 10.1038/S41577-019-0250-4  0.365
2019 Howe M, Bauer J, Schulze A, Kropp S, Locksley RM, Alferink J, Weighardt H, Scheu S. Production of IFNβ by Conventional Dendritic Cells after Stimulation with Viral Compounds and IFNβ-Independent IFNAR1-Signaling Pathways are Associated with Aggravation of Polymicrobial Sepsis. International Journal of Molecular Sciences. 20. PMID 31500303 DOI: 10.3390/Ijms20184410  0.509
2019 Ricardo-Gonzalez RR, Locksley RM. ILC2s chew the fat. The Journal of Experimental Medicine. PMID 31405894 DOI: 10.1084/Jem.20191098  0.394
2019 Schneider C, Lee J, Koga S, Ricardo-Gonzalez RR, Nussbaum JC, Smith LK, Villeda SA, Liang HE, Locksley RM. Tissue-Resident Group 2 Innate Lymphoid Cells Differentiate by Layered Ontogeny and In Situ Perinatal Priming. Immunity. PMID 31128962 DOI: 10.1016/J.Immuni.2019.04.019  0.358
2019 Schneider C, O'Leary CE, Locksley RM. Regulation of immune responses by tuft cells. Nature Reviews. Immunology. PMID 31114038 DOI: 10.1038/S41577-019-0176-X  0.463
2018 O'Leary CE, Schneider C, Locksley RM. Tuft Cells-Systemically Dispersed Sensory Epithelia Integrating Immune and Neural Circuitry. Annual Review of Immunology. PMID 30379593 DOI: 10.1146/Annurev-Immunol-042718-041505  0.472
2018 Ricardo-Gonzalez RR, Van Dyken SJ, Schneider C, Lee J, Nussbaum JC, Liang HE, Vaka D, Eckalbar WL, Molofsky AB, Erle DJ, Locksley RM. Tissue signals imprint ILC2 identity with anticipatory function. Nature Immunology. PMID 30201992 DOI: 10.1038/S41590-018-0201-4  0.506
2018 Vivier E, Artis D, Colonna M, Diefenbach A, Di Santo JP, Eberl G, Koyasu S, Locksley RM, McKenzie ANJ, Mebius RE, Powrie F, Spits H. Innate Lymphoid Cells: 10 Years On. Cell. 174: 1054-1066. PMID 30142344 DOI: 10.1016/J.Cell.2018.07.017  0.424
2018 Miller CN, Proekt I, von Moltke J, Wells KL, Rajpurkar AR, Wang H, Rattay K, Khan IS, Metzger TC, Pollack JL, Fries AC, Lwin WW, Wigton EJ, Parent AV, Kyewski B, ... ... Locksley RM, et al. Thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development. Nature. PMID 30022164 DOI: 10.1038/S41586-018-0345-2  0.796
2018 Nadjsombati MS, McGinty JW, Lyons-Cohen MR, Jaffe JB, DiPeso L, Schneider C, Miller CN, Pollack JL, Nagana Gowda GA, Fontana MF, Erle DJ, Anderson MS, Locksley RM, Raftery D, von Moltke J. Detection of Succinate by Intestinal Tuft Cells Triggers a Type 2 Innate Immune Circuit. Immunity. 49: 33-41.e7. PMID 30021144 DOI: 10.1016/J.Immuni.2018.06.016  0.744
2018 Nusse YM, Savage AK, Marangoni P, Rosendahl-Huber AKM, Landman TA, de Sauvage FJ, Locksley RM, Klein OD. Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche. Nature. PMID 29950724 DOI: 10.1038/S41586-018-0257-1  0.397
2018 Kotas ME, Locksley RM. Why Innate Lymphoid Cells? Immunity. 48: 1081-1090. PMID 29924974 DOI: 10.1016/J.Immuni.2018.06.002  0.467
2018 Schneider C, O'Leary CE, von Moltke J, Liang HE, Ang QY, Turnbaugh PJ, Radhakrishnan S, Pellizzon M, Ma A, Locksley RM. A Metabolite-Triggered Tuft Cell-ILC2 Circuit Drives Small Intestinal Remodeling. Cell. PMID 29887373 DOI: 10.1016/J.Cell.2018.05.014  0.76
2018 Sui P, Wiesner DL, Xu J, Zhang Y, Lee J, Van Dyken S, Lashua A, Yu C, Klein BS, Locksley RM, Deutsch G, Sun X. Pulmonary neuroendocrine cells amplify allergic asthma responses. Science (New York, N.Y.). PMID 29599193 DOI: 10.1126/Science.Aan8546  0.381
2018 Ricardo-Gonzalez R, Van Dyken S, Locksley R. 940 ILC2s and Type 2 immunity influence hair follicle stem cell proliferation and skin homeostasis Journal of Investigative Dermatology. 138: S160. DOI: 10.1016/J.Jid.2018.03.952  0.334
2017 Odegaard JI, Lee MW, Sogawa Y, Bertholet AM, Locksley RM, Weinberg DE, Kirichok Y, Deo RC, Chawla A. Perinatal Licensing of Thermogenesis by IL-33 and ST2. Cell. 171: 1707. PMID 29245014 DOI: 10.1016/j.cell.2017.12.003  0.354
2017 Singh PB, Pua HH, Happ HC, Schneider C, von Moltke J, Locksley RM, Baumjohann D, Ansel KM. MicroRNA regulation of type 2 innate lymphoid cell homeostasis and function in allergic inflammation. The Journal of Experimental Medicine. PMID 29122948 DOI: 10.1084/Jem.20170545  0.751
2017 Savage AK, Liang HE, Locksley RM. The Development of Steady-State Activation Hubs between Adult LTi ILC3s and Primed Macrophages in Small Intestine. Journal of Immunology (Baltimore, Md. : 1950). PMID 28747343 DOI: 10.4049/Jimmunol.1700155  0.559
2017 Lechner AJ, Driver IH, Lee J, Conroy CM, Nagle A, Locksley RM, Rock JR. Recruited Monocytes and Type 2 Immunity Promote Lung Regeneration following Pneumonectomy. Cell Stem Cell. PMID 28506464 DOI: 10.1016/J.Stem.2017.03.024  0.413
2017 Van Dyken SJ, Liang HE, Naikawadi RP, Woodruff PG, Wolters PJ, Erle DJ, Locksley RM. Spontaneous Chitin Accumulation in Airways and Age-Related Fibrotic Lung Disease. Cell. 169: 497-509.e13. PMID 28431248 DOI: 10.1016/J.Cell.2017.03.044  0.35
2016 von Moltke J, O'Leary CE, Barrett NA, Kanaoka Y, Austen KF, Locksley RM. Leukotrienes provide an NFAT-dependent signal that synergizes with IL-33 to activate ILC2s. The Journal of Experimental Medicine. PMID 28011865 DOI: 10.1084/Jem.20161274  0.805
2016 Lee LM, Ji M, Sinha M, Dong MB, Ren X, Wang Y, Lowell CA, Ghosh S, Locksley RM, DeFranco AL. Determinants of Divergent Adaptive Immune Responses after Airway Sensitization with Ligands of Toll-Like Receptor 5 or Toll-Like Receptor 9. Plos One. 11: e0167693. PMID 27977701 DOI: 10.1371/Journal.Pone.0167693  0.58
2016 Van Dyken SJ, Nussbaum JC, Lee J, Molofsky AB, Liang HE, Pollack JL, Gate RE, Haliburton GE, Ye CJ, Marson A, Erle DJ, Locksley RM. A tissue checkpoint regulates type 2 immunity. Nature Immunology. PMID 27749840 DOI: 10.1038/Ni.3582  0.554
2016 Belinson H, Savage AK, Fadrosh D, Kuo YM, Lin D, Valladares R, Nusse Y, Wynshaw-Boris A, Lynch SV, Locksley RM, Klein OD. Dual epithelial and immune cell function of Dvl1 regulates gut microbiota composition and intestinal homeostasis. Jci Insight. 1. PMID 27525310 DOI: 10.1172/Jci.Insight.85395  0.425
2016 Odegaard JI, Lee MW, Sogawa Y, Bertholet AM, Locksley RM, Weinberg DE, Kirichok Y, Deo RC, Chawla A. Perinatal Licensing of Thermogenesis by IL-33 and ST2. Cell. PMID 27453471 DOI: 10.1016/J.Cell.2016.06.040  0.495
2016 Gordon ED, Locksley RM, Fahy JV. Cross-Talk between Epithelial Cells and Type 2 Immune Signaling. The Role of IL-25. American Journal of Respiratory and Critical Care Medicine. 193: 935-6. PMID 27128698 DOI: 10.1164/Rccm.201512-2534Ed  0.511
2016 Mohapatra A, Van Dyken SJ, Schneider C, Nussbaum JC, Liang HE, Locksley RM. Group 2 innate lymphoid cells utilize the IRF4-IL-9 module to coordinate epithelial cell maintenance of lung homeostasis. Mucosal Immunology. 9: 275-86. PMID 26129648 DOI: 10.1038/Mi.2015.59  0.837
2016 Singh PB, Pua HH, Baumjohann D, Schneider C, Moltke Jv, Locksley RM, Ansel KM. A microRNA regulation of type 2 innate lymphoid cells-promotes th2 cytokine production and induces allergic inflammation Cytokine. DOI: 10.1016/J.Cyto.2016.07.020  0.445
2015 von Moltke J, Ji M, Liang HE, Locksley RM. Tuft-cell-derived IL-25 regulates an intestinal ILC2-epithelial response circuit. Nature. PMID 26675736 DOI: 10.1038/Nature16161  0.82
2015 Molofsky AB, Van Gool F, Liang HE, Van Dyken SJ, Nussbaum JC, Lee J, Bluestone JA, Locksley RM. Interleukin-33 and Interferon-γ Counter-Regulate Group 2 Innate Lymphoid Cell Activation during Immune Perturbation. Immunity. 43: 161-74. PMID 26092469 DOI: 10.1016/J.Immuni.2015.05.019  0.558
2015 Molofsky AB, Savage AK, Locksley RM. Interleukin-33 in Tissue Homeostasis, Injury, and Inflammation. Immunity. 42: 1005-19. PMID 26084021 DOI: 10.1016/J.Immuni.2015.06.006  0.595
2015 Schwartz C, Willebrand R, Huber S, Rupec RA, Wu D, Locksley R, Voehringer D. Eosinophil-specific deletion of IκBα in mice reveals a critical role of NF-κB-induced Bcl-xL for inhibition of apoptosis. Blood. 125: 3896-904. PMID 25862560 DOI: 10.1182/Blood-2014-10-607788  0.823
2015 Cheng LE, Sullivan BM, Retana LE, Allen CD, Liang HE, Locksley RM. IgE-activated basophils regulate eosinophil tissue entry by modulating endothelial function. The Journal of Experimental Medicine. 212: 513-24. PMID 25779634 DOI: 10.1084/Jem.20141671  0.476
2015 Reinhardt RL, Liang HE, Bao K, Price AE, Mohrs M, Kelly BL, Locksley RM. A novel model for IFN-γ-mediated autoinflammatory syndromes. Journal of Immunology (Baltimore, Md. : 1950). 194: 2358-68. PMID 25637019 DOI: 10.4049/Jimmunol.1401992  0.417
2015 Lee MW, Odegaard JI, Mukundan L, Qiu Y, Molofsky AB, Nussbaum JC, Yun K, Locksley RM, Chawla A. Activated type 2 innate lymphoid cells regulate beige fat biogenesis. Cell. 160: 74-87. PMID 25543153 DOI: 10.1016/J.Cell.2014.12.011  0.517
2015 Bando JK, Liang HE, Locksley RM. Identification and distribution of developing innate lymphoid cells in the fetal mouse intestine. Nature Immunology. 16: 153-60. PMID 25501629 DOI: 10.1038/Ni.3057  0.356
2015 Cheng LE, Locksley RM. Allergic inflammation--innately homeostatic. Cold Spring Harbor Perspectives in Biology. 7: a016352. PMID 25414367 DOI: 10.1101/Cshperspect.A016352  0.351
2014 von Moltke J, Locksley RM. I-L-C-2 it: type 2 immunity and group 2 innate lymphoid cells in homeostasis. Current Opinion in Immunology. 31: 58-65. PMID 25458996 DOI: 10.1016/J.Coi.2014.09.009  0.768
2014 Van Gool F, Molofsky AB, Morar MM, Rosenzwajg M, Liang HE, Klatzmann D, Locksley RM, Bluestone JA. Interleukin-5-producing group 2 innate lymphoid cells control eosinophilia induced by interleukin-2 therapy. Blood. 124: 3572-6. PMID 25323825 DOI: 10.1182/Blood-2014-07-587493  0.52
2014 Qiu Y, Nguyen KD, Odegaard JI, Cui X, Tian X, Locksley RM, Palmiter RD, Chawla A. Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat. Cell. 157: 1292-308. PMID 24906148 DOI: 10.1016/J.Cell.2014.03.066  0.429
2014 Patnode ML, Bando JK, Krummel MF, Locksley RM, Rosen SD. Leukotriene B4 amplifies eosinophil accumulation in response to nematodes. The Journal of Experimental Medicine. 211: 1281-8. PMID 24889202 DOI: 10.1084/Jem.20132336  0.387
2014 O'Dea EM, Amarsaikhan N, Li H, Downey J, Steele E, Van Dyken SJ, Locksley RM, Templeton SP. Eosinophils are recruited in response to chitin exposure and enhance Th2-mediated immune pathology in Aspergillus fumigatus infection. Infection and Immunity. 82: 3199-205. PMID 24842927 DOI: 10.1128/Iai.01990-14  0.428
2014 Van Dyken SJ, Mohapatra A, Nussbaum JC, Molofsky AB, Thornton EE, Ziegler SF, McKenzie AN, Krummel MF, Liang HE, Locksley RM. Chitin activates parallel immune modules that direct distinct inflammatory responses via innate lymphoid type 2 and γδ T cells. Immunity. 40: 414-24. PMID 24631157 DOI: 10.1016/J.Immuni.2014.02.003  0.848
2013 Hams E, Locksley RM, McKenzie AN, Fallon PG. Cutting edge: IL-25 elicits innate lymphoid type 2 and type II NKT cells that regulate obesity in mice. Journal of Immunology (Baltimore, Md. : 1950). 191: 5349-53. PMID 24166975 DOI: 10.4049/Jimmunol.1301176  0.469
2013 Nussbaum JC, Van Dyken SJ, von Moltke J, Cheng LE, Mohapatra A, Molofsky AB, Thornton EE, Krummel MF, Chawla A, Liang HE, Locksley RM. Type 2 innate lymphoid cells control eosinophil homeostasis. Nature. 502: 245-8. PMID 24037376 DOI: 10.1038/Nature12526  0.832
2013 Bando JK, Nussbaum JC, Liang HE, Locksley RM. Type 2 innate lymphoid cells constitutively express arginase-I in the naive and inflamed lung. Journal of Leukocyte Biology. 94: 877-84. PMID 23924659 DOI: 10.1189/Jlb.0213084  0.531
2013 Goh YP, Henderson NC, Heredia JE, Red Eagle A, Odegaard JI, Lehwald N, Nguyen KD, Sheppard D, Mukundan L, Locksley RM, Chawla A. Eosinophils secrete IL-4 to facilitate liver regeneration. Proceedings of the National Academy of Sciences of the United States of America. 110: 9914-9. PMID 23716700 DOI: 10.1073/Pnas.1304046110  0.393
2013 Heredia JE, Mukundan L, Chen FM, Mueller AA, Deo RC, Locksley RM, Rando TA, Chawla A. Type 2 innate signals stimulate fibro/adipogenic progenitors to facilitate muscle regeneration. Cell. 153: 376-88. PMID 23582327 DOI: 10.1016/J.Cell.2013.02.053  0.479
2013 Locksley RM. Raggin' on T-bet. Cell Metabolism. 17: 473-4. PMID 23562073 DOI: 10.1016/J.Cmet.2013.03.012  0.344
2013 Molofsky AB, Nussbaum JC, Liang HE, Van Dyken SJ, Cheng LE, Mohapatra A, Chawla A, Locksley RM. Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages. The Journal of Experimental Medicine. 210: 535-49. PMID 23420878 DOI: 10.1084/Jem.20121964  0.828
2013 Spits H, Artis D, Colonna M, Diefenbach A, Di Santo JP, Eberl G, Koyasu S, Locksley RM, McKenzie AN, Mebius RE, Powrie F, Vivier E. Innate lymphoid cells--a proposal for uniform nomenclature. Nature Reviews. Immunology. 13: 145-9. PMID 23348417 DOI: 10.1038/Nri3365  0.385
2013 Oghumu S, Dong R, Varikuti S, Shawler T, Kampfrath T, Terrazas CA, Lezama-Davila C, Ahmer BM, Whitacre CC, Rajagopalan S, Locksley R, Sharpe AH, Satoskar AR. Distinct populations of innate CD8+ T cells revealed in a CXCR3 reporter mouse. Journal of Immunology (Baltimore, Md. : 1950). 190: 2229-40. PMID 23338236 DOI: 10.4049/Jimmunol.1201170  0.521
2013 Van Dyken SJ, Locksley RM. Interleukin-4- and interleukin-13-mediated alternatively activated macrophages: roles in homeostasis and disease. Annual Review of Immunology. 31: 317-43. PMID 23298208 DOI: 10.1146/Annurev-Immunol-032712-095906  0.557
2013 Cheng LE, Hartmann K, Roers A, Krummel MF, Locksley RM. Perivascular mast cells dynamically probe cutaneous blood vessels to capture immunoglobulin E. Immunity. 38: 166-75. PMID 23290520 DOI: 10.1016/J.Immuni.2012.09.022  0.4
2013 Van Dyken SJ, Mohapatra A, Nussbaum JC, Liang H, Locksley RM. 265 Cytokine. 63: 306. DOI: 10.1016/J.Cyto.2013.06.268  0.84
2012 Dickgreber N, Farrand KJ, van Panhuys N, Knight DA, McKee SJ, Chong ML, Miranda-Hernandez S, Baxter AG, Locksley RM, Le Gros G, Hermans IF. Immature murine NKT cells pass through a stage of developmentally programmed innate IL-4 secretion. Journal of Leukocyte Biology. 92: 999-1009. PMID 22941735 DOI: 10.1189/Jlb.0512242  0.563
2012 Price AE, Reinhardt RL, Liang HE, Locksley RM. Marking and quantifying IL-17A-producing cells in vivo. Plos One. 7: e39750. PMID 22768117 DOI: 10.1371/Journal.Pone.0039750  0.541
2012 Thornton EE, Looney MR, Bose O, Sen D, Sheppard D, Locksley R, Huang X, Krummel MF. Spatiotemporally separated antigen uptake by alveolar dendritic cells and airway presentation to T cells in the lung. The Journal of Experimental Medicine. 209: 1183-99. PMID 22585735 DOI: 10.1084/Jem.20112667  0.364
2012 Nussbaum JC, Locksley RM. Infectious (Non)tolerance--frustrated commensalism gone awry? Cold Spring Harbor Perspectives in Biology. 4. PMID 22456498 DOI: 10.1101/Cshperspect.A007328  0.301
2012 Liang HE, Reinhardt RL, Bando JK, Sullivan BM, Ho IC, Locksley RM. Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity. Nature Immunology. 13: 58-66. PMID 22138715 DOI: 10.1038/Ni.2182  0.576
2011 Nguyen KD, Qiu Y, Cui X, Goh YP, Mwangi J, David T, Mukundan L, Brombacher F, Locksley RM, Chawla A. Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis. Nature. 480: 104-8. PMID 22101429 DOI: 10.1038/Nature10653  0.415
2011 Elliott ER, Van Ziffle JA, Scapini P, Sullivan BM, Locksley RM, Lowell CA. Deletion of Syk in neutrophils prevents immune complex arthritis. Journal of Immunology (Baltimore, Md. : 1950). 187: 4319-30. PMID 21918195 DOI: 10.4049/Jimmunol.1100341  0.349
2011 Van Dyken SJ, Garcia D, Porter P, Huang X, Quinlan PJ, Blanc PD, Corry DB, Locksley RM. Fungal chitin from asthma-associated home environments induces eosinophilic lung infiltration. Journal of Immunology (Baltimore, Md. : 1950). 187: 2261-7. PMID 21824866 DOI: 10.4049/Jimmunol.1100972  0.349
2011 Sullivan BM, Liang HE, Bando JK, Wu D, Cheng LE, McKerrow JK, Allen CD, Locksley RM. Genetic analysis of basophil function in vivo. Nature Immunology. 12: 527-35. PMID 21552267 DOI: 10.1038/Ni.2036  0.845
2011 Wu D, Molofsky AB, Liang HE, Ricardo-Gonzalez RR, Jouihan HA, Bando JK, Chawla A, Locksley RM. Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis. Science (New York, N.Y.). 332: 243-7. PMID 21436399 DOI: 10.1126/Science.1201475  0.82
2011 Svensson M, Bell L, Little MC, Deschoolmeester M, Locksley RM, Else KJ. Accumulation of eosinophils in intestine-draining mesenteric lymph nodes occurs after Trichuris muris infection Parasite Immunology. 33: 1-11. PMID 21155838 DOI: 10.1111/J.1365-3024.2010.01246.X  0.468
2011 Duerr CU, Salzman NH, Dupont A, Szabo A, Normark BH, Normark S, Locksley RM, Mellroth P, Hornef MW. Control of intestinal Nod2-mediated peptidoglycan recognition by epithelium-associated lymphocytes. Mucosal Immunology. 4: 325-34. PMID 20980996 DOI: 10.1038/Mi.2010.71  0.438
2010 Ricardo-Gonzalez RR, Red Eagle A, Odegaard JI, Jouihan H, Morel CR, Heredia JE, Mukundan L, Wu D, Locksley RM, Chawla A. IL-4/STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity. Proceedings of the National Academy of Sciences of the United States of America. 107: 22617-22. PMID 21149710 DOI: 10.1073/Pnas.1009152108  0.806
2010 Yang Z, Wang ZE, Doulias PT, Wei W, Ischiropoulos H, Locksley RM, Liu L. Lymphocyte development requires S-nitrosoglutathione reductase. Journal of Immunology (Baltimore, Md. : 1950). 185: 6664-9. PMID 20980633 DOI: 10.4049/Jimmunol.1000080  0.379
2010 Cheng LE, Wang ZE, Locksley RM. Murine B cells regulate serum IgE levels in a CD23-dependent manner. Journal of Immunology (Baltimore, Md. : 1950). 185: 5040-7. PMID 20870945 DOI: 10.4049/Jimmunol.1001900  0.391
2010 Price AE, Liang HE, Sullivan BM, Reinhardt RL, Eisley CJ, Erle DJ, Locksley RM. Systemically dispersed innate IL-13-expressing cells in type 2 immunity. Proceedings of the National Academy of Sciences of the United States of America. 107: 11489-94. PMID 20534524 DOI: 10.1073/Pnas.1003988107  0.559
2010 Locksley RM. Asthma and allergic inflammation. Cell. 140: 777-83. PMID 20303868 DOI: 10.1016/J.Cell.2010.03.004  0.337
2009 Barbalat R, Lau L, Locksley RM, Barton GM. Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands. Nature Immunology. 10: 1200-7. PMID 19801985 DOI: 10.1038/Ni.1792  0.333
2009 Mingueneau M, Roncagalli R, Grégoire C, Kissenpfennig A, Miazek A, Archambaud C, Wang Y, Perrin P, Bertosio E, Sansoni A, Richelme S, Locksley RM, Aguado E, Malissen M, Malissen B. Loss of the LAT Adaptor Converts Antigen-Responsive T Cells into Pathogenic Effectors that Function Independently of the T Cell Receptor Immunity. 31: 197-208. PMID 19682930 DOI: 10.1016/J.Immuni.2009.05.013  0.433
2009 Voehringer D, Wu D, Liang HE, Locksley RM. Efficient generation of long-distance conditional alleles using recombineering and a dual selection strategy in replicate plates. Bmc Biotechnology. 9: 69. PMID 19638212 DOI: 10.1186/1472-6750-9-69  0.758
2009 Locksley RM. Nine lives: plasticity among T helper cell subsets. The Journal of Experimental Medicine. 206: 1643-6. PMID 19635860 DOI: 10.1084/Jem.20091442  0.434
2009 Rothfuchs AG, Egen JG, Feng CG, Antonelli LR, Bafica A, Winter N, Locksley RM, Sher A. In situ IL-12/23p40 production during mycobacterial infection is sustained by CD11bhigh dendritic cells localized in tissue sites distinct from those harboring bacilli. Journal of Immunology (Baltimore, Md. : 1950). 182: 6915-25. PMID 19454688 DOI: 10.4049/Jimmunol.0900074  0.449
2009 Kroeger KM, Sullivan BM, Locksley RM. IL-18 and IL-33 elicit Th2 cytokines from basophils via a MyD88- and p38alpha-dependent pathway. Journal of Leukocyte Biology. 86: 769-78. PMID 19451398 DOI: 10.1189/Jlb.0708452  0.49
2009 Reinhardt RL, Liang HE, Locksley RM. Cytokine-secreting follicular T cells shape the antibody repertoire. Nature Immunology. 10: 385-93. PMID 19252490 DOI: 10.1038/Ni.1715  0.469
2009 Sullivan BM, Locksley RM. Basophils: a nonredundant contributor to host immunity. Immunity. 30: 12-20. PMID 19144314 DOI: 10.1016/J.Immuni.2008.12.006  0.395
2009 Locksley RM, Sullivan B, Lee Reinhardt R, Wu D, Van Dyken S, Kang S, Price A, Bando J, Liang H. Tracking cytokine expression in vivo Cytokine. 48: 3. DOI: 10.1016/J.Cyto.2009.07.016  0.784
2008 Scheu S, Dresing P, Locksley RM. Visualization of IFNbeta production by plasmacytoid versus conventional dendritic cells under specific stimulation conditions in vivo. Proceedings of the National Academy of Sciences of the United States of America. 105: 20416-21. PMID 19088190 DOI: 10.1073/Pnas.0808537105  0.416
2008 Kang SJ, Liang HE, Reizis B, Locksley RM. Regulation of hierarchical clustering and activation of innate immune cells by dendritic cells. Immunity. 29: 819-33. PMID 19006696 DOI: 10.1016/J.Immuni.2008.09.017  0.409
2008 Cisse B, Caton ML, Lehner M, Maeda T, Scheu S, Locksley R, Holmberg D, Zweier C, den Hollander NS, Kant SG, Holter W, Rauch A, Zhuang Y, Reizis B. Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development. Cell. 135: 37-48. PMID 18854153 DOI: 10.1016/J.Cell.2008.09.016  0.371
2008 Robinson RT, Khader SA, Locksley RM, Lien E, Smiley ST, Cooper AM. Yersinia pestis evades TLR4-dependent induction of IL-12(p40)2 by dendritic cells and subsequent cell migration. Journal of Immunology (Baltimore, Md. : 1950). 181: 5560-7. PMID 18832714 DOI: 10.4049/Jimmunol.181.8.5560  0.464
2008 Mamchak AA, Sullivan BM, Hou B, Lee LM, Gilden JK, Krummel MF, Locksley RM, DeFranco AL. Normal development and activation but altered cytokine production of Fyn-deficient CD4+ T cells. Journal of Immunology (Baltimore, Md. : 1950). 181: 5374-85. PMID 18832694 DOI: 10.4049/Jimmunol.181.8.5374  0.463
2008 Jensen KD, Su X, Shin S, Li L, Youssef S, Yamasaki S, Steinman L, Saito T, Locksley RM, Davis MM, Baumgarth N, Chien YH. Thymic selection determines gammadelta T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon gamma. Immunity. 29: 90-100. PMID 18585064 DOI: 10.1016/J.Immuni.2008.04.022  0.522
2008 Locksley RM. The Roaring Twenties. Immunity. 28: 437-9. PMID 18400185 DOI: 10.1016/J.Immuni.2008.03.009  0.349
2008 Voehringer D, Liang HE, Locksley RM. Homeostasis and effector function of lymphopenia-induced "memory-like" T cells in constitutively T cell-depleted mice. Journal of Immunology (Baltimore, Md. : 1950). 180: 4742-53. PMID 18354198 DOI: 10.4049/Jimmunol.180.7.4742  0.43
2007 Van Dyken SJ, Locksley RM. Autoimmunity: altered self-N-glycans trigger innate-mediated autoimmunity. Immunology and Cell Biology. 85: 572-4. PMID 17909561 DOI: 10.1038/Sj.Icb.7100122  0.396
2007 Launois P, Pingel S, Himmelrich H, Locksley R, Louis J. Different epitopes of the LACK protein are recognized by V beta 4 V alpha 8 CD4+ T cells in H-2b and H-2d mice susceptible to Leishmania major. Microbes and Infection. 9: 1260-6. PMID 17890126 DOI: 10.1016/J.Micinf.2007.05.017  0.451
2007 Mueller SN, Hosiawa-Meagher KA, Konieczny BT, Sullivan BM, Bachmann MF, Locksley RM, Ahmed R, Matloubian M. Regulation of homeostatic chemokine expression and cell trafficking during immune responses Science. 317: 670-674. PMID 17673664 DOI: 10.1126/Science.1144830  0.451
2007 Nurieva RI, Chuvpilo S, Wieder ED, Elkon KB, Locksley R, Serfling E, Dong C. A costimulation-initiated signaling pathway regulates NFATc1 transcription in T lymphocytes. Journal of Immunology (Baltimore, Md. : 1950). 179: 1096-103. PMID 17617602 DOI: 10.4049/Jimmunol.179.2.1096  0.422
2007 Reese TA, Liang HE, Tager AM, Luster AD, Van Rooijen N, Voehringer D, Locksley RM. Chitin induces accumulation in tissue of innate immune cells associated with allergy. Nature. 447: 92-6. PMID 17450126 DOI: 10.1038/Nature05746  0.573
2007 Voehringer D, Stanley SA, Cox JS, Completo GC, Lowary TL, Locksley RM. Nippostrongylus brasiliensis: identification of intelectin-1 and -2 as Stat6-dependent genes expressed in lung and intestine during infection. Experimental Parasitology. 116: 458-66. PMID 17420014 DOI: 10.1016/J.Exppara.2007.02.015  0.485
2007 Khader SA, Bell GK, Pearl JE, Fountain JJ, Rangel-Moreno J, Cilley GE, Shen F, Eaton SM, Gaffen SL, Swain SL, Locksley RM, Haynes L, Randall TD, Cooper AM. IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge. Nature Immunology. 8: 369-77. PMID 17351619 DOI: 10.1038/Ni1449  0.514
2007 Voehringer D, van Rooijen N, Locksley RM. Eosinophils develop in distinct stages and are recruited to peripheral sites by alternatively activated macrophages. Journal of Leukocyte Biology. 81: 1434-44. PMID 17339609 DOI: 10.1189/Jlb.1106686  0.397
2006 Xu X, Zhang D, Zhang H, Wolters PJ, Killeen NP, Sullivan BM, Locksley RM, Lowell CA, Caughey GH. Neutrophil histamine contributes to inflammation in mycoplasma pneumonia. The Journal of Experimental Medicine. 203: 2907-17. PMID 17158962 DOI: 10.1084/Jem.20061232  0.371
2006 Locksley RM. A failure to launch: fuelling cytokine secretion in iNKT cells. Immunity. 25: 393-5. PMID 16979571 DOI: 10.1016/J.Immuni.2006.08.012  0.44
2006 Fife BT, Griffin MD, Abbas AK, Locksley RM, Bluestone JA. Inhibition of T cell activation and autoimmune diabetes using a B cell surface-linked CTLA-4 agonist. The Journal of Clinical Investigation. 116: 2252-61. PMID 16886063 DOI: 10.1172/Jci27856  0.441
2006 Reinhardt RL, Hong S, Kang SJ, Wang ZE, Locksley RM. Visualization of IL-12/23p40 in vivo reveals immunostimulatory dendritic cell migrants that promote Th1 differentiation. Journal of Immunology (Baltimore, Md. : 1950). 177: 1618-27. PMID 16849470 DOI: 10.4049/Jimmunol.177.3.1618  0.48
2006 Voehringer D, Reese TA, Huang X, Shinkai K, Locksley RM. Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system. The Journal of Experimental Medicine. 203: 1435-46. PMID 16702603 DOI: 10.1084/Jem.20052448  0.734
2006 Scheu S, Stetson DB, Reinhardt RL, Leber JH, Mohrs M, Locksley RM. Activation of the integrated stress response during T helper cell differentiation. Nature Immunology. 7: 644-51. PMID 16680145 DOI: 10.1038/Ni1338  0.718
2006 Gumy A, Aseffa A, Rachinel N, Breton M, Otten L, Tacchini-Cottier F, Röcken M, Doyen N, Acha-Orbea H, Locksley RM, MacDonald HR, Launois P, Louis J. LACK-reactive CD4+ T cells require autocrine IL-2 to mediate susceptibility to Leishmania major. European Journal of Immunology. 36: 1465-73. PMID 16637008 DOI: 10.1002/Eji.200535801  0.552
2006 Hayashida T, Oda M, Ohsawa K, Yamaguchi A, Hosozawa T, Locksley RM, Giacca M, Masai H, Miyatake S. Replication initiation from a novel origin identified in the Th2 cytokine cluster locus requires a distant conserved noncoding sequence. Journal of Immunology (Baltimore, Md. : 1950). 176: 5446-54. PMID 16622012 DOI: 10.4049/Jimmunol.176.9.5446  0.53
2006 Reinhardt RL, Kang SJ, Liang HE, Locksley RM. T helper cell effector fates--who, how and where? Current Opinion in Immunology. 18: 271-7. PMID 16617008 DOI: 10.1016/J.Coi.2006.03.003  0.515
2006 Veldhoen M, Hocking RJ, Atkins CJ, Locksley RM, Stockinger B. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity. 24: 179-89. PMID 16473830 DOI: 10.1016/J.Immuni.2006.01.001  0.562
2006 Tang Q, Adams JY, Tooley AJ, Bi M, Fife BT, Serra P, Santamaria P, Locksley RM, Krummel MF, Bluestone JA. Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice. Nature Immunology. 7: 83-92. PMID 16311599 DOI: 10.1038/Ni1289  0.415
2006 Voehringer D, Reese TA, Huang X, Shinkai K, Locksley RM. Correction Journal of Experimental Medicine. 203: 1617-1617. DOI: 10.1084/Jem.20052448051806C  0.485
2005 Im W, Kim H, Yun D, Seo SY, Park SH, Locksley RM, Hong S. Cytokine reporter mouse system for screening novel IL12/23 p40-inducing compounds. Molecules and Cells. 20: 288-96. PMID 16267405  0.413
2005 Mohrs K, Wakil AE, Killeen N, Locksley RM, Mohrs M. A two-step process for cytokine production revealed by IL-4 dual-reporter mice. Immunity. 23: 419-29. PMID 16226507 DOI: 10.1016/J.Immuni.2005.09.006  0.56
2005 Loke P, Zang X, Hsuan L, Waitz R, Locksley RM, Allen JE, Allison JP. Inducible costimulator is required for type 2 antibody isotype switching but not T helper cell type 2 responses in chronic nematode infection. Proceedings of the National Academy of Sciences of the United States of America. 102: 9872-7. PMID 15994233 DOI: 10.1073/Pnas.0503961102  0.491
2005 Ohmura K, Nguyen LT, Locksley RM, Mathis D, Benoist C. Interleukin-4 can be a key positive regulator of inflammatory arthritis. Arthritis and Rheumatism. 52: 1866-75. PMID 15934072 DOI: 10.1002/Art.21104  0.445
2004 Kelly BL, Locksley RM. The Leishmania major LACK antigen with an immunodominant epitope at amino acids 156 to 173 is not required for early Th2 development in BALB/c mice Infection and Immunity. 72: 6924-6931. PMID 15557613 DOI: 10.1128/Iai.72.12.6924-6931.2004  0.477
2004 Voehringer D, Rosen DB, Lanier LL, Locksley RM. CD200 receptor family members represent novel DAP12-associated activating receptors on basophils and mast cells. The Journal of Biological Chemistry. 279: 54117-23. PMID 15471863 DOI: 10.1074/Jbc.M406997200  0.403
2004 Xu M, Wang Z, Locksley RM. Innate immune responses in peptidoglycan recognition protein L-deficient mice. Molecular and Cellular Biology. 24: 7949-57. PMID 15340057 DOI: 10.1128/Mcb.24.18.7949-7957.2004  0.365
2004 Stetson DB, Voehringer D, Grogan JL, Xu M, Reinhardt RL, Scheu S, Kelly BL, Locksley RM. Th2 cells: orchestrating barrier immunity. Advances in Immunology. 83: 163-89. PMID 15135631 DOI: 10.1016/S0065-2776(04)83005-0  0.75
2004 Voehringer D, Shinkai K, Locksley RM. Type 2 immunity reflects orchestrated recruitment of cells committed to IL-4 production. Immunity. 20: 267-77. PMID 15030771 DOI: 10.1016/S1074-7613(04)00026-3  0.742
2003 Grogan JL, Wang ZE, Stanley S, Harmon B, Loots GG, Rubin EM, Locksley RM. Basal chromatin modification at the IL-4 gene in helper T cells. Journal of Immunology (Baltimore, Md. : 1950). 171: 6672-9. PMID 14662870 DOI: 10.4049/Jimmunol.171.12.6672  0.534
2003 Kelly BL, Stetson DB, Locksley RM. Leishmania major LACK Antigen Is Required for Efficient Vertebrate Parasitization Journal of Experimental Medicine. 198: 1689-1698. PMID 14657221 DOI: 10.1084/Jem.20031162  0.674
2003 Stetson DB, Mohrs M, Reinhardt RL, Baron JL, Wang ZE, Gapin L, Kronenberg M, Locksley RM. Constitutive cytokine mRNAs mark natural killer (NK) and NK T cells poised for rapid effector function. The Journal of Experimental Medicine. 198: 1069-76. PMID 14530376 DOI: 10.1084/Jem.20030630  0.759
2003 Matsuda JL, Gapin L, Baron JL, Sidobre S, Stetson DB, Mohrs M, Locksley RM, Kronenberg M. Mouse V alpha 14i natural killer T cells are resistant to cytokine polarization in vivo. Proceedings of the National Academy of Sciences of the United States of America. 100: 8395-400. PMID 12829795 DOI: 10.1073/Pnas.1332805100  0.742
2003 Hadeiba H, Locksley RM. Lung CD25 CD4 regulatory T cells suppress type 2 immune responses but not bronchial hyperreactivity. Journal of Immunology (Baltimore, Md. : 1950). 170: 5502-10. PMID 12759427 DOI: 10.4049/Jimmunol.170.11.5502  0.778
2003 Mohrs M, Lacy DA, Locksley RM. Stat signals release activated naive Th cells from an anergic checkpoint. Journal of Immunology (Baltimore, Md. : 1950). 170: 1870-6. PMID 12574353 DOI: 10.4049/Jimmunol.170.4.1870  0.546
2003 Bour-Jordan H, Grogan JL, Tang Q, Auger JA, Locksley RM, Bluestone JA. CTLA-4 regulates the requirement for cytokine-induced signals in T(H)2 lineage commitment. Nature Immunology. 4: 182-8. PMID 12524538 DOI: 10.1038/Ni884  0.418
2002 Shinkai K, Mohrs M, Locksley RM. Helper T cells regulate type-2 innate immunity in vivo. Nature. 420: 825-9. PMID 12490951 DOI: 10.1038/Nature01202  0.738
2002 Stetson DB, Mohrs M, Mallet-Designe V, Teyton L, Locksley RM. Rapid expansion and IL-4 expression by Leishmania-specific naive helper T cells in vivo. Immunity. 17: 191-200. PMID 12196290 DOI: 10.1016/S1074-7613(02)00363-1  0.787
2002 Grogan JL, Locksley RM. T helper cell differentiation: on again, off again. Current Opinion in Immunology. 14: 366-72. PMID 11973136 DOI: 10.1016/S0952-7915(02)00340-0  0.46
2002 Launois P, Gumy A, Himmelrich H, Locksley RM, Röcken M, Louis JA. Rapid IL-4 production by Leishmania homolog of mammalian RACK1-reactive CD4(+) T cells in resistant mice treated once with anti-IL-12 or -IFN-gamma antibodies at the onset of infection with Leishmania major instructs Th2 cell development, resulting in nonhealing lesions. Journal of Immunology (Baltimore, Md. : 1950). 168: 4628-35. PMID 11971011 DOI: 10.4049/Jimmunol.168.9.4628  0.549
2002 Baron JL, Gardiner L, Nishimura S, Shinkai K, Locksley R, Ganem D. Activation of a nonclassical NKT cell subset in a transgenic mouse model of hepatitis B virus infection. Immunity. 16: 583-94. PMID 11970881 DOI: 10.1016/S1074-7613(02)00305-9  0.623
2002 Locksley RM. A Pox on You Cell. 109: 671-672. DOI: 10.1016/S0092-8674(02)00779-1  0.353
2001 Riese RJ, Shi GP, Villadangos J, Stetson D, Driessen C, Lennon-Dumenil AM, Chu CL, Naumov Y, Behar SM, Ploegh H, Locksley R, Chapman HA. Regulation of CD1 function and NK1.1(+) T cell selection and maturation by cathepsin S. Immunity. 15: 909-19. PMID 11754813 DOI: 10.1016/S1074-7613(01)00247-3  0.683
2001 Davies SJ, Grogan JL, Blank RB, Lim KC, Locksley RM, McKerrow JH. Modulation of blood fluke development in the liver by hepatic CD4+ lymphocytes. Science (New York, N.Y.). 294: 1358-61. PMID 11701932 DOI: 10.1126/Science.1064462  0.326
2001 Mohrs M, Blankespoor CM, Wang ZE, Loots GG, Afzal V, Hadeiba H, Shinkai K, Rubin EM, Locksley RM. Deletion of a coordinate regulator of type 2 cytokine expression in mice. Nature Immunology. 2: 842-7. PMID 11526400 DOI: 10.1038/Ni0901-842  0.84
2001 Mohrs M, Shinkai K, Mohrs K, Locksley RM. Analysis of type 2 immunity in vivo with a bicistronic IL-4 reporter. Immunity. 15: 303-11. PMID 11520464 DOI: 10.1016/S1074-7613(01)00186-8  0.72
2001 Maillard I, Launois P, Himmelrich H, Acha-Orbea H, Diggelmann H, Locksley RM, Louis JA. Functional plasticity of the LACK-reactive Vbeta4-Valpha8 CD4(+) T cells normally producing the early IL-4 instructing Th2 cell development and susceptibility to Leishmania major in BALB / c mice. European Journal of Immunology. 31: 1288-96. PMID 11298356 DOI: 10.1002/1521-4141(200104)31:4<1288::Aid-Immu1288>3.0.Co;2-8  0.543
2001 Bottrel RL, Dutra WO, Martins FA, Gontijo B, Carvalho E, Barral-Netto M, Barral A, Almeida RP, Mayrink W, Locksley R, Gollob KJ. Flow cytometric determination of cellular sources and frequencies of key cytokine-producing lymphocytes directed against recombinant LACK and soluble Leishmania antigen in human cutaneous leishmaniasis. Infection and Immunity. 69: 3232-9. PMID 11292745 DOI: 10.1128/Iai.69.5.3232-3239.2001  0.521
2001 Grogan JL, Mohrs M, Harmon B, Lacy DA, Sedat JW, Locksley RM. Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets. Immunity. 14: 205-15. PMID 11290331 DOI: 10.1016/S1074-7613(01)00103-0  0.511
2000 Kelly BL, Locksley RM. Coordinate regulation of the IL-4, IL-13, and IL-5 cytokine cluster in Th2 clones revealed by allelic expression patterns Journal of Immunology. 165: 2982-2986. PMID 10975806 DOI: 10.4049/Jimmunol.165.6.2982  0.529
2000 Gurunathan S, Stobie L, Prussin C, Sacks DL, Glaichenhaus N, Iwasaki A, Fowell DJ, Locksley RM, Chang JT, Wu CY, Seder RA. Requirements for the maintenance of Th1 immunity in vivo following DNA vaccination: a potential immunoregulatory role for CD8+ T cells. Journal of Immunology (Baltimore, Md. : 1950). 165: 915-24. PMID 10878366 DOI: 10.4049/Jimmunol.165.2.915  0.399
2000 Hadeiba H, Corry DB, Locksley RM. Baseline airway hyperreactivity in A/J mice is not mediated by cells of the adaptive immune system. Journal of Immunology (Baltimore, Md. : 1950). 164: 4933-40. PMID 10779804 DOI: 10.4049/Jimmunol.164.9.4933  0.781
2000 Himmelrich H, Launois P, Maillard I, Biedermann T, Tacchini-Cottier F, Locksley RM, Röcken M, Louis JA. In BALB/c mice, IL-4 production during the initial phase of infection with Leishmania major is necessary and sufficient to instruct Th2 cell development resulting in progressive disease. Journal of Immunology (Baltimore, Md. : 1950). 164: 4819-25. PMID 10779790 DOI: 10.4049/Jimmunol.164.9.4819  0.523
2000 Lacy DA, Wang ZE, Symula DJ, McArthur CJ, Rubin EM, Frazer KA, Locksley RM. Faithful expression of the human 5q31 cytokine cluster in transgenic mice. Journal of Immunology (Baltimore, Md. : 1950). 164: 4569-74. PMID 10779759 DOI: 10.4049/Jimmunol.164.9.4569  0.505
2000 Shinkai K, Locksley RM. CD1, tuberculosis, and the evolution of major histocompatibility complex molecules. The Journal of Experimental Medicine. 191: 907-14. PMID 10727453 DOI: 10.1084/Jem.191.6.907  0.542
1999 Fowell DJ, Shinkai K, Liao XC, Beebe AM, Coffman RL, Littman DR, Locksley RM. Impaired NFATc translocation and failure of Th2 development in Itk- deficient CD4+ T cells Immunity. 11: 399-409. PMID 10549622 DOI: 10.1016/S1074-7613(00)80115-6  0.72
1999 Symula DJ, Frazer KA, Ueda Y, Denefle P, Stevens ME, Wang ZE, Locksley R, Rubin EM. Functional screening of an asthma QTL in YAC transgenic mice. Nature Genetics. 23: 241-4. PMID 10508526 DOI: 10.1038/13880  0.424
1999 Fowell DJ, Locksley RM. Leishmania major infection of inbred mice: unmasking genetic determinants of infectious diseases. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 21: 510-8. PMID 10402957 DOI: 10.1002/(Sici)1521-1878(199906)21:6<510::Aid-Bies7>3.0.Co;2-5  0.469
1999 Pingel S, Launois P, Fowell DJ, Turck CW, Southwood S, Sette A, Glaichenhaus N, Louis JA, Locksley RM. Altered ligands reveal limited plasticity in the T cell response to a pathogenic epitope. The Journal of Experimental Medicine. 189: 1111-20. PMID 10190902 DOI: 10.1084/Jem.189.7.1111  0.503
1999 Locksley RM, Pingel S, Lacy D, Wakil AE, Bix M, Fowell DJ. Susceptibility to infectious diseases: Leishmania as a paradigm. The Journal of Infectious Diseases. S305-8. PMID 10081500 DOI: 10.1086/513843  0.388
1999 Bix M, Wang ZE, Thiel B, Schork NJ, Locksley RM. Genetic regulation of commitment to interleukin 4 production by a CD4(+) T cell-intrinsic mechanism. The Journal of Experimental Medicine. 188: 2289-99. PMID 9858515 DOI: 10.1084/Jem.188.12.2289  0.57
1999 Grünig G, Warnock M, Wakil AE, Venkayya R, Brombacher F, Rennick DM, Sheppard D, Mohrs M, Donaldson DD, Locksley RM, Corry DB. Requirement for IL-13 independently of IL-4 in experimental asthma. Science (New York, N.Y.). 282: 2261-3. PMID 9856950 DOI: 10.1126/Science.282.5397.2261  0.497
1998 Locksley RM, Fowell DJ, Shinkai K, Wakil AE, Lacy D, Bix M. Development of CD4+ effector T cells and susceptibility to infectious diseases. Advances in Experimental Medicine and Biology. 452: 45-52. PMID 9889958 DOI: 10.1007/978-1-4615-5355-7_6  0.653
1998 Fowell DJ, Bix M, Shinkai K, Lacy D, Locksley RM. Disease susceptibility and development of the cytokine repertoire in the murine Leishmania major model. European Cytokine Network. 9: 102-6. PMID 9831197  0.642
1998 Wakil AE, Wang ZE, Ryan JC, Fowell DJ, Locksley RM. Interferon gamma derived from CD4(+) T cells is sufficient to mediate T helper cell type 1 development. The Journal of Experimental Medicine. 188: 1651-6. PMID 9802977 DOI: 10.1084/Jem.188.9.1651  0.542
1998 Bix M, Locksley RM. Independent and epigenetic regulation of the interleukin-4 alleles in CD4+ T cells. Science (New York, N.Y.). 281: 1352-4. PMID 9721100 DOI: 10.1126/Science.281.5381.1352  0.516
1998 Corry DB, Grünig G, Hadeiba H, Kurup VP, Warnock ML, Sheppard D, Rennick DM, Locksley RM. Requirements for allergen-induced airway hyperreactivity in T and B cell-deficient mice. Molecular Medicine (Cambridge, Mass.). 4: 344-55. PMID 9642684  0.775
1998 Corry DB, Grünig G, Hadeiba H, Kurup VP, Warnock ML, Sheppard D, Rennick DM, Locksley RM. Requirements for Allergen-Induced Airway Hyperreactivity in T and B Cell-Deficient Mice Molecular Medicine. 4: 344-355. DOI: 10.1007/Bf03401741  0.819
1997 McSorley SJ, Soldera S, Malherbe L, Carnaud C, Locksley RM, Flavell RA, Glaichenhaus N. Immunological tolerance to a pancreatic antigen as a result of local expression of TNFalpha by islet beta cells. Immunity. 7: 401-9. PMID 9324360 DOI: 10.1016/S1074-7613(00)80361-1  0.451
1997 Hagenbaugh A, Sharma S, Dubinett SM, Wei SH, Aranda R, Cheroutre H, Fowell DJ, Binder S, Tsao B, Locksley RM, Moore KW, Kronenberg M. Altered immune responses in interleukin 10 transgenic mice. The Journal of Experimental Medicine. 185: 2101-10. PMID 9182682 DOI: 10.1084/Jem.185.12.2101  0.583
1997 Fowell DJ, Magram J, Turck CW, Killeen N, Locksley RM. Impaired Th2 subset development in the absence of CD4 Immunity. 6: 559-569. PMID 9175834 DOI: 10.1016/S1074-7613(00)80344-1  0.432
1997 Launois P, Maillard I, Pingel S, Swihart KG, Xénarios I, Acha-Orbea H, Diggelmann H, Locksley RM, MacDonald HR, Louis JA. IL-4 rapidly produced by V beta 4 V alpha 8 CD4+ T cells instructs Th2 development and susceptibility to Leishmania major in BALB/c mice. Immunity. 6: 541-9. PMID 9175832 DOI: 10.1016/S1074-7613(00)80342-8  0.496
1997 Stevenson FT, Turck J, Locksley RM, Lovett DH. The N-terminal propiece of interleukin 1 alpha is a transforming nuclear oncoprotein. Proceedings of the National Academy of Sciences of the United States of America. 94: 508-13. PMID 9012814 DOI: 10.1073/Pnas.94.2.508  0.439
1997 Brown DR, Swier K, Moskowitz NH, Naujokas MF, Locksley RM, Reiner SL. T helper subset differentiation in the absence of invariant chain Journal of Experimental Medicine. 185: 31-41. PMID 8996239 DOI: 10.1084/Jem.185.1.31  0.693
1996 Wakil AE, Wang ZE, Locksley RM. Leishmania major: targeting IL-4 in successful immunomodulation of murine infection. Experimental Parasitology. 84: 214-22. PMID 8932771 DOI: 10.1006/Expr.1996.0107  0.52
1996 Brown DR, Fowell DJ, Corry DB, Wynn TA, Moskowitz NH, Cheever AW, Locksley RM, Reiner SL. β2-Microglobulin-dependent NK1.1+ T cells are not essential for T helper cell 2 immune responses Journal of Experimental Medicine. 184: 1295-1304. PMID 8879201 DOI: 10.1084/Jem.184.4.1295  0.739
1996 Roth I, Corry DB, Locksley RM, Abrams JS, Litton MJ, Fisher SJ. Human placental cytotrophoblasts produce the immunosuppressive cytokine interleukin 10. The Journal of Experimental Medicine. 184: 539-48. PMID 8760807 DOI: 10.1084/Jem.184.2.539  0.51
1996 Locksley RM, Wakil AE, Corry DB, Pingel S, Bix M, Fowell DJ. The development of effector T cell subsets in murine Leishmania major infection. Ciba Foundation Symposium. 195: 110-7; discussion 11. PMID 8724833 DOI: 10.1002/9780470514849.ch8  0.43
1996 Corry DB, Ampel NM, Christian L, Locksley RM, Galgiani JN. Cytokine production by peripheral blood mononuclear cells in human coccidioidomycosis. The Journal of Infectious Diseases. 174: 440-3. PMID 8699085 DOI: 10.1093/Infdis/174.2.440  0.475
1996 Fearon DT, Locksley RM. The instructive role of innate immunity in the acquired immune response Science. 272: 50-54. PMID 8600536 DOI: 10.1126/Science.272.5258.50  0.337
1996 Corry DB, Folkesson HG, Warnock ML, Erle DJ, Matthay MA, Wiener-Kronish JP, Locksley RM. Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity. The Journal of Experimental Medicine. 183: 109-17. PMID 8551213 DOI: 10.1084/Jem.183.1.109  0.542
1995 Mougneau E, Altare F, Wakil AE, Zheng S, Coppola T, Wang ZE, Waldmann R, Locksley RM, Glaichenhaus N. Expression cloning of a protective Leishmania antigen. Science (New York, N.Y.). 268: 563-6. PMID 7725103 DOI: 10.1126/Science.7725103  0.417
1995 Reiner SL, Locksley RM. The regulation of immunity to Leishmania major Annual Review of Immunology. 13: 151-177. PMID 7612219 DOI: 10.1146/Annurev.Iy.13.040195.001055  0.7
1994 Holaday BJ, Pompeu MM, Jeronimo S, Texeira MJ, Sousa Ade A, Vasconcelos AW, Pearson RD, Abrams JS, Locksley RM. Potential role for interleukin-10 in the immunosuppression associated with kala azar. The Journal of Clinical Investigation. 92: 2626-32. PMID 8254019 DOI: 10.1172/Jci116878  0.508
1994 Locksley RM. Th2 cells: help for helminths. The Journal of Experimental Medicine. 179: 1405-7. PMID 8163928 DOI: 10.1084/Jem.179.5.1405  0.401
1994 Reiner SL, Zheng S, Corry DB, Locksley RM. Constructing polycompetitor cDNAs for quantitative PCR. J. Immunol. Methods 165 (1993) 37-46 (PII:0022-1759(93)90104-F) Journal of Immunological Methods. 173: 133. PMID 8034981 DOI: 10.1016/0022-1759(94)90291-7  0.508
1994 Reiner SL, Zheng S, Corry DB, Locksley RM. Constructing polycompetitor cDNAs for quantitative PCR. (J. Immunol. Methods 165 (1993) 37-46; 173 (1994) 133) (PII:0022-1759(94)00210-X) Journal of Immunological Methods. 175: 275. PMID 7930655 DOI: 10.1016/0022-1759(94)90370-0  0.509
1994 Wang ZE, Reiner SL, Zheng S, Dalton DK, Locksley RM. CD4+ effector cells default to the Th2 pathway in interferon γ-deficient mice infected with Leishmania major Journal of Experimental Medicine. 179: 1367-1371. PMID 7908325 DOI: 10.1084/Jem.179.4.1367  0.724
1994 Reiner SL, Zheng S, Wang ZE, Stowring L, Locksley RM. Leishmania promastigotes evade interleukin 12 (IL-12) induction by macrophages and stimulate a broad range of cytokines from CD4+ T cells during initiation of infection Journal of Experimental Medicine. 179: 447-456. PMID 7905017 DOI: 10.1084/Jem.179.2.447  0.72
1994 Wang ZE, Zheng S, Corry DB, Dalton DK, Seder RA, Reiner SL, Locksley RM. Interferon γ-independent effects of interleukin 12 administered during acute or established infection due to Leishmania major Proceedings of the National Academy of Sciences of the United States of America. 91: 12932-12936. PMID 7809149 DOI: 10.1073/Pnas.91.26.12932  0.715
1993 Reiner SL, Wang ZE, Hatam F, Scott P, Locksley RM. TH1 and TH2 cell antigen receptors in experimental leishmaniasis Science. 259: 1457-1463. PMID 8451641 DOI: 10.1126/Science.8451641  0.646
1993 Holaday BJ, Pompeu MMdL, Evans T, Braga DNdM, Texeira MJ, Sousa AdQ, Sadick MD, Vasconcelos AW, Abrams JS, Pearson RD, Locksley RM. Correlates of Leishmania-Specific Immunity in the Clinical Spectrum of Infection with Leishmania chagasi The Journal of Infectious Diseases. 167: 411-417. PMID 8421174 DOI: 10.1093/Infdis/167.2.411  0.399
1993 Reiner SL, Zheng S, Corry DB, Locksley RM. Constructing polycompetitor cDNAs for quantitative PCR Journal of Immunological Methods. 165: 37-46. PMID 8409467 DOI: 10.1016/0022-1759(93)90104-F  0.564
1993 Locksley RM, Reiner SL, Hatam F, Littman DR, Killeen N. Helper T cells without CD4: Control of leishmaniasis in CD4-deficient mice Science. 261: 1448-1451. PMID 8367726 DOI: 10.1126/Science.8367726  0.612
1993 Stevenson FT, Bursten SL, Fanton C, Locksley RM, Lovett DH. The 31-kDa precursor of interleukin 1 alpha is myristoylated on specific lysines within the 16-kDa N-terminal propiece. Proceedings of the National Academy of Sciences of the United States of America. 90: 7245-9. PMID 8346241 DOI: 10.1073/Pnas.90.15.7245  0.419
1993 Reiner SL, Locksley RM. Cytokines in the differentiation of Th1/Th2 CD4+ subsets in leishmaniasis Journal of Cellular Biochemistry. 53: 323-328. PMID 7905485 DOI: 10.1002/Jcb.240530409  0.649
1993 Reiner SL, Locksley RM. The worm and the protozoa: Stereotyped responses or distinct antigens? Parasitology Today. 9: 258-260. DOI: 10.1016/0169-4758(93)90071-M  0.662
1992 Stevenson FT, Torrano F, Locksley RM, Lovett DH. Interleukin 1: the patterns of translation and intracellular distribution support alternative secretory mechanisms. Journal of Cellular Physiology. 152: 223-31. PMID 1639857 DOI: 10.1002/Jcp.1041520202  0.444
1992 Amiri P, Locksley RM, Parslow TG, Sadick M, Rector E, Ritter D, McKerrow JH. Tumour necrosis factor alpha restores granulomas and induces parasite egg-laying in schistosome-infected SCID mice. Nature. 356: 604-7. PMID 1560843 DOI: 10.1038/356604A0  0.346
1992 Stevenson FT, Bursten SL, Locksley RM, Lovett DH. Myristyl acylation of the tumor necrosis factor alpha precursor on specific lysine residues. The Journal of Experimental Medicine. 176: 1053-62. PMID 1402651 DOI: 10.1084/Jem.176.4.1053  0.336
1992 Locksley RM, Louis JA. Immunology of leishmaniasis. Current Opinion in Immunology. 4: 413-8. PMID 1356346 DOI: 10.1016/S0952-7915(06)80032-4  0.463
1992 LOCKSLEY R. Immunology of leishmaniasis Current Biology. 2: 460. DOI: 10.1016/0960-9822(92)90649-U  0.316
1991 Gardner KD, Burnside JS, Elzinga LW, Locksley RM. Cytokines in fluids from polycystic kidneys Kidney International. 39: 718-724. PMID 2051729 DOI: 10.1038/Ki.1991.87  0.435
1991 Sadick MD, Street N, Mosmann TR, Locksley RM. Cytokine regulation of murine leishmaniasis: Interleukin 4 is not sufficient to mediate progressive disease in resistant C57BL/6 mice Infection and Immunity. 59: 4710-4714. PMID 1937832 DOI: 10.1128/Iai.59.12.4710-4714.1991  0.482
1991 Heinzel FP, Sadick MD, Mutha SS, Locksley RM. Production of interferon gamma, interleukin 2, interleukin 4, and interleukin 10 by CD4+ lymphocytes in vivo during healing and progressive murine leishmaniasis. Proceedings of the National Academy of Sciences of the United States of America. 88: 7011-5. PMID 1908085 DOI: 10.1073/Pnas.88.16.7011  0.53
1991 Bernstein MS, Tong-Starksen SE, Locksley RM. Activation of human monocyte--derived macrophages with lipopolysaccharide decreases human immunodeficiency virus replication in vitro at the level of gene expression. The Journal of Clinical Investigation. 88: 540-5. PMID 1907615 DOI: 10.1172/Jci115337  0.323
1991 Locksley RM, Scott P. Helper T-cell subsets in mouse leishmaniasis: induction, expansion and effector function. Immunology Today. 12: A58-61. PMID 1829891 DOI: 10.1016/S0167-5699(05)80017-9  0.442
1991 Locksley RM, Heinzel FP, Holaday BJ, Mutha SS, Reiner SL, Sadick MD. Induction of Th1 and Th2 CD4+ subsets during murine Leishmania major infection Research in Immunology. 142: 28-32. PMID 1829257 DOI: 10.1016/0923-2494(91)90007-6  0.589
1991 Locksley RM, Scott P. Helper T-cell subsets in mouse leishmaniasis: induction, expansion and effector function Parasitology Today. 7: 58-61. DOI: 10.1016/0169-4758(91)90034-L  0.409
1990 Sadick MD, Heinzel FP, Holaday BJ, Pu RT, Dawkins RS, Locksley RM. Cure of murine leishmaniasis with anti-interleukin 4 monoclonal antibody. Evidence for a T cell-dependent, interferon gamma-independent mechanism. The Journal of Experimental Medicine. 171: 115-27. PMID 2104918 DOI: 10.1084/Jem.171.1.115  0.507
1989 Heinzel FP, Sadick MD, Holaday BJ, Coffman RL, Locksley RM. Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets. The Journal of Experimental Medicine. 169: 59-72. PMID 2521244 DOI: 10.1084/Jem.169.1.59  0.503
1988 Locksley RM, Crowe S, Sadick MD, Heinzel FP, Gardner KD, McGrath MS, Mills J. Release of interleukin 1 inhibitory activity (contra-IL-1) by human monocyte-derived macrophages infected with human immunodeficiency virus in vitro and in vivo. The Journal of Clinical Investigation. 82: 2097-105. PMID 3264291 DOI: 10.1172/Jci113831  0.52
1988 Bursten SL, Locksley RM, Ryan JL, Lovett DH. Acylation of monocyte and glomerular mesangial cell proteins. Myristyl acylation of the interleukin 1 precursors Journal of Clinical Investigation. 82: 1479-1488. PMID 3263392 DOI: 10.1172/Jci113755  0.43
1988 Heinzel FP, Sadick MD, Locksley RM. Leishmania major: analysis of lymphocyte and macrophage cellular phenotypes during infection of susceptible and resistant mice. Experimental Parasitology. 65: 258-68. PMID 3127233 DOI: 10.1016/0014-4894(88)90130-0  0.392
1988 Locksley RM, Heinzel FP, Fankhauser JE, Nelson CS, Sadick MD. Cutaneous host defense in leishmaniasis: Interaction of isolated dermal macrophages and epidermal Langerhans cells with the insect-stage promastigote Infection and Immunity. 56: 336-342. PMID 2828237 DOI: 10.1128/Iai.56.2.336-342.1988  0.37
1987 Locksley RM, Heinzel FP, Sadick MD, Holaday BJ, Gardner KD. Murine cutaneous leishmaniasis: susceptibility correlates with differential expansion of helper T-cell subsets. Annales De L'Institut Pasteur. Immunology. 138: 744-9. PMID 2964247 DOI: 10.1016/S0769-2625(87)80030-2  0.479
1984 Sadick MD, Locksley RM, Raff HV. Development of cellular immunity in cutaneous leishmaniasis due to Leishmania tropica. The Journal of Infectious Diseases. 150: 135-8. PMID 6611378 DOI: 10.1093/Infdis/150.1.135  0.408
1984 Locksley RM, Klebanoff SJ. Oxygen-dependent microbicidal systems of phagocytes and host defense against intracellular protozoa. Journal of Cellular Biochemistry. 22: 173-85. PMID 6365936 DOI: 10.1002/Jcb.240220306  0.339
1983 Locksley R, Wilson C, Klebanoff S. Increased respiratory burst in myeloperoxidase-deficient monocytes Blood. 62: 902-909. DOI: 10.1182/Blood.V62.4.902.Bloodjournal624902  0.361
1982 Locksley RM, Wilson CB, Klebanoff SJ. Role for endogenous and acquired peroxidase in the toxoplasmacidal activity of murine and human mononuclear phagocytes. The Journal of Clinical Investigation. 69: 1099-111. PMID 7068848 DOI: 10.1172/Jci110545  0.336
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