Richard Bucala - Publications

Affiliations: 
Yale University, New Haven, CT 
Area:
Microbiology Biology, Parasitology Biology

115 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Tilstam PV, Pantouris G, Corman M, Andreoli M, Mahboubi K, Davis G, Du X, Leng L, Lolis E, Bucala R. A selective small-molecule inhibitor of macrophage migration inhibitory factor-2 (MIF-2), a MIF cytokine superfamily member, inhibits MIF-2 biological activity. The Journal of Biological Chemistry. PMID 31578280 DOI: 10.1074/jbc.RA119.009860  0.44
2019 Huang H, Chen D, Pu J, Yuan A, Fu Q, Li J, Leng L, Bucala R, Ye S, Lu L. The small molecule macrophage migration inhibitory factor antagonist MIF098, inhibits pulmonary hypertension associated with murine SLE. International Immunopharmacology. 76: 105874. PMID 31499270 DOI: 10.1016/j.intimp.2019.105874  0.44
2019 Ma Y, Su KN, Pfau D, Rao VS, Wu X, Hu X, Leng L, Du X, Piecychna M, Bedi K, Campbell SG, Eichmann A, Testani JM, Margulies KB, Bucala R, et al. Cardiomyocyte d-dopachrome tautomerase protects against heart failure. Jci Insight. 4. PMID 31484822 DOI: 10.1172/jci.insight.128900  0.44
2019 Smith CA, Tyrell DJ, Kulkarni UA, Wood S, Leng L, Zemans RL, Bucala R, Goldstein DR. Macrophage migration inhibitory factor enhances influenza-associated mortality in mice. Jci Insight. 4. PMID 31292300 DOI: 10.1172/jci.insight.128034  0.44
2019 Ma F, Kouzoukas DE, Meyer-Siegler KL, Hunt DE, Leng L, Bucala R, Vera PL. MIF mediates bladder pain, not inflammation, in cyclophosphamide cystitis. Cytokine: X. 1. PMID 31289792 DOI: 10.1016/j.cytox.2019.100003  0.44
2019 Poulsen KL, McMullen MR, Huang E, Kibler CD, Sheehan M, Leng L, Bucala R, Nagy LE. Novel Role of Macrophage Migration Inhibitory Factor in Upstream Control of the Unfolded Protein Response after Ethanol Feeding in Mice. Alcoholism, Clinical and Experimental Research. PMID 31009094 DOI: 10.1111/acer.14065  0.44
2019 Kim HK, Garcia AB, Siu E, Tilstam P, Das R, Roberts S, Leng L, Bucala R. Macrophage migration inhibitory factor regulates innate γδ T-cell responses via IL-17 expression. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201802433R. PMID 30817226 DOI: 10.1096/fj.201802433R  0.44
2019 Zheng J, Guo R, Tang Y, Fu Q, Chen J, Wu L, Leng L, Bucala R, Song Y, Lu L. miR-152 Attenuates the Severity of Lupus Nephritis Through the Downregulation of Macrophage Migration Inhibitory Factor (MIF)-Induced Expression of COL1A1. Frontiers in Immunology. 10: 158. PMID 30787934 DOI: 10.3389/fimmu.2019.00158  0.44
2019 Ma F, Meyer-Siegler KL, Leng L, Bucala R, Vera PL. Spinal macrophage migration inhibitory factor and high mobility group box 1 mediate persistent bladder pain. Neuroscience Letters. PMID 30708129 DOI: 10.1016/j.neulet.2019.01.046  0.44
2018 Zhang C, Ramsey C, Berical A, Yu L, Leng L, McGinnis K, Song YS, Michael H, McCormack M, Allore H, Morris A, Crothers K, Bucala R, Lee PJ, Sauler M. A Functional Macrophage Migration Inhibitory Factor (MIF) Promoter Polymorphism is Associated with Reduced Diffusing Capacity. American Journal of Physiology. Lung Cellular and Molecular Physiology. PMID 30520689 DOI: 10.1152/ajplung.00439.2018  0.44
2018 Bezdek S, Leng L, Busch H, Mousavi S, Rades D, Dahlke M, Zillikens D, Bucala R, Sadik CD. (MIF) Drives Murine Psoriasiform Dermatitis. Frontiers in Immunology. 9: 2262. PMID 30333830 DOI: 10.3389/fimmu.2018.02262  0.44
2018 Cui D, Peng Y, Zhang C, Li Z, Su Y, Qi Y, Xing M, Li J, Kim GE, Su KN, Xu J, Wang M, Ding W, Piecychna M, Leng L, ... ... Bucala R, et al. Macrophage migration inhibitory factor mediates metabolic dysfunction induced by atypical antipsychotic therapy. The Journal of Clinical Investigation. PMID 30295645 DOI: 10.1172/JCI93090  0.44
2018 Pellowe AS, Sauler M, Hou Y, Merola J, Liu R, Calderon B, Lauridsen HM, Harris MR, Leng L, Zhang Y, Tilstam PV, Pober JS, Bucala R, Lee PJ, Gonzalez AL. Endothelial cell-secreted MIF reduces pericyte contractility and enhances neutrophil extravasation. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201800480R. PMID 30252532 DOI: 10.1096/fj.201800480R  0.44
2018 Ma F, Hunt DE, Leng L, Bucala R, Meyer-Siegler KL, Vera PL. Protease activated-receptor 4 activation as a model of persistent bladder pain: Essential role of macrophage migration inhibitory factor and high mobility group box 1. International Journal of Urology : Official Journal of the Japanese Urological Association. PMID 30112848 DOI: 10.1111/iju.13778  0.44
2018 Shin MS, Kang Y, Wahl ER, Park HJ, Lazova R, Leng L, Mamula M, Krishnaswamy S, Bucala R, Kang I. Macrophage migration inhibitory factor regulates U1-snRNP immune complex mediated activation of the NLRP3 inflammasome. Arthritis & Rheumatology (Hoboken, N.J.). PMID 30009530 DOI: 10.1002/art.40672  0.44
2018 Baeza Garcia A, Siu E, Sun T, Exler V, Brito L, Hekele A, Otten G, Augustijn K, Janse CJ, Ulmer JB, Bernhagen J, Fikrig E, Geall A, Bucala R. Neutralization of the Plasmodium-encoded MIF ortholog confers protective immunity against malaria infection. Nature Communications. 9: 2714. PMID 30006528 DOI: 10.1038/s41467-018-05041-7  0.48
2018 Trifone C, Salido J, Ruiz MJ, Leng L, Quiroga MF, Salomón H, Bucala R, Ghiglione Y, Turk G. Interaction Between Macrophage Migration Inhibitory Factor and CD74 in Human Immunodeficiency Virus Type I Infected Primary Monocyte-Derived Macrophages Triggers the Production of Proinflammatory Mediators and Enhances Infection of Unactivated CD4 T Cells. Frontiers in Immunology. 9: 1494. PMID 29997630 DOI: 10.3389/fimmu.2018.01494  0.44
2018 Sreih AG, Ezzedine R, Leng L, Fan J, Yao J, Reid D, Piecychna M, Carette S, Cuthbertson D, Dellaripa P, Hoffman GS, Khalidi NA, Koening CL, Langford CA, Mahr A, ... ... Bucala R, et al. Role of macrophage migration inhibitory factor in granulomatosis with polyangiitis. Arthritis & Rheumatology (Hoboken, N.J.). PMID 29953750 DOI: 10.1002/art.40655  0.44
2018 Jose S, Mukherjee A, Abhyankar MM, Leng L, Bucala R, Sharma D, Madan R. Neutralization of macrophage migration inhibitory factor improves host survival after Clostridium difficile infection. Anaerobe. PMID 29944928 DOI: 10.1016/j.anaerobe.2018.06.014  0.44
2018 Valiño-Rivas L, Cuarental L, Grana O, Bucala R, Leng L, Sanz A, Gomez G, Ortiz A, Sanchez-Niño MD. TWEAK increases CD74 expression and sensitizes to DDT proinflammatory actions in tubular cells. Plos One. 13: e0199391. PMID 29924850 DOI: 10.1371/journal.pone.0199391  0.44
2018 Lipschutz R, Bick J, Nguyen V, Lee M, Leng L, Grigorenko E, Bucala R, Mayes LC, Crowley MJ. Macrophage migration inhibitory factor (MIF) gene is associated with adolescents' cortisol reactivity and anxiety. Psychoneuroendocrinology. 95: 170-178. PMID 29870971 DOI: 10.1016/j.psyneuen.2018.05.033  0.44
2018 Stoppe C, Averdunk L, Goetzenich A, Soppert J, Marlier A, Kraemer S, Vieten J, Coburn M, Kowark A, Kim BS, Marx G, Rex S, Ochi A, Leng L, Moeckel G, ... ... Bucala R, et al. The protective role of macrophage migration inhibitory factor in acute kidney injury after cardiac surgery. Science Translational Medicine. 10. PMID 29769287 DOI: 10.1126/scitranslmed.aan4886  0.44
2018 Pantouris G, Ho J, Shah D, Syed MA, Leng L, Bhandari V, Bucala R, Batista VS, Loria JP, Lolis E. Nanosecond Dynamics Regulate the MIF-Induced Activity of CD74. Angewandte Chemie (International Ed. in English). PMID 29669180 DOI: 10.1002/anie.201803191  0.44
2017 You S, Koh JH, Leng L, Kim WU, Bucala R. The Tumor-like Phenotype of Rheumatoid Synovium: Molecular Profiling and Prospects for Precision Medicine. Arthritis & Rheumatology (Hoboken, N.J.). PMID 29287304 DOI: 10.1002/art.40406  0.44
2017 Ma F, Kouzoukas DE, Meyer-Siegler KL, Hunt DE, Leng L, Bucala R, Vera PL. Macrophage migration inhibitory factor mediates protease-activated receptor 4-induced bladder pain through urothelial high mobility group box 1. Physiological Reports. 5. PMID 29263120 DOI: 10.14814/phy2.13549  0.44
2017 Benedek G, Meza-Romero R, Jordan K, Zhang Y, Nguyen H, Kent G, Li J, Siu E, Frazer J, Piecychna M, Du X, Sreih A, Leng L, Wiedrick J, Caillier SJ, ... ... Bucala R, et al. MIF and D-DT are potential disease severity modifiers in male MS subjects. Proceedings of the National Academy of Sciences of the United States of America. PMID 28923927 DOI: 10.1073/pnas.1712288114  0.44
2017 Djudjaj S, Martin IV, Buhl EM, Nothofer NJ, Leng L, Piecychna M, Floege J, Bernhagen J, Bucala R, Boor P. Macrophage Migration Inhibitory Factor Limits Renal Inflammation and Fibrosis by Counteracting Tubular Cell Cycle Arrest. Journal of the American Society of Nephrology : Jasn. PMID 28801314 DOI: 10.1681/ASN.2017020190  0.44
2017 Tynan A, Mawhinney L, Armstrong ME, O'Reilly C, Kennedy S, Caraher E, Jülicher K, O'Dwyer D, Maher L, Schaffer K, Fabre A, McKone EF, Leng L, Bucala R, Bernhagen J, et al. Macrophage migration inhibitory factor enhances Pseudomonas aeruginosa biofilm formation potentially contributing to cystic fibrosis pathogenesis. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 28768722 DOI: 10.1096/fj.201700463R  0.44
2017 Tilstam PV, Qi D, Leng L, Young L, Bucala R. MIF family cytokines in cardiovascular diseases and prospects for precision-based therapeutics. Expert Opinion On Therapeutic Targets. PMID 28562118 DOI: 10.1080/14728222.2017.1336227  0.44
2017 Ochi A, Chen D, Schulte W, Leng L, Moeckel NG, Piecychna M, Averdunk L, Stoppe C, Bucala R, Moeckel GW. MIF-2/D-DT Enhances Proximal Tubular Cell Regeneration Through SLPI and ATF4-dependent Mechanisms. American Journal of Physiology. Renal Physiology. ajprenal.00683.2016. PMID 28539339 DOI: 10.1152/ajprenal.00683.2016  0.44
2017 Roger T, Schlapbach LJ, Schneider A, Weier M, Wellmann S, Marquis P, Vermijlen D, Sweep FC, Leng L, Bucala R, Calandra T, Giannoni E. Plasma Levels of Macrophage Migration Inhibitory Factor and d-Dopachrome Tautomerase Show a Highly Specific Profile in Early Life. Frontiers in Immunology. 8: 26. PMID 28179905 DOI: 10.3389/fimmu.2017.00026  0.44
2016 Yoo SA, Leng L, Kim BJ, Du X, Tilstam PV, Kim KH, Kong JS, Yoon HJ, Liu A, Wang T, Song Y, Sauler M, Bernhagen J, Ritchlin CT, Lee P, ... ... Bucala R, et al. MIF allele-dependent regulation of the MIF coreceptor CD44 and role in rheumatoid arthritis. Proceedings of the National Academy of Sciences of the United States of America. PMID 27872288 DOI: 10.1073/pnas.1612717113  0.44
2016 Assis DN, Takahashi H, Leng L, Zeniya M, Boyer JL, Bucala R. A Macrophage Migration Inhibitory Factor Polymorphism Is Associated with Autoimmune Hepatitis Severity in US and Japanese Patients. Digestive Diseases and Sciences. PMID 27696094 DOI: 10.1007/s10620-016-4322-z  0.44
2016 Stijlemans B, Brys L, Korf H, Bieniasz-Krzywiec P, Sparkes A, Vansintjan L, Leng L, Vanbekbergen N, Mazzone M, Caljon G, Van Den Abbeele J, Odongo S, De Trez C, Magez S, Van Ginderachter JA, ... ... Bucala R, et al. MIF-Mediated Hemodilution Promotes Pathogenic Anemia in Experimental African Trypanosomosis. Plos Pathogens. 12: e1005862. PMID 27632207 DOI: 10.1371/journal.ppat.1005862  0.44
2016 Kim BS, Tilstam PV, Hwang SS, Simons D, Schulte W, Leng L, Sauler M, Ganse B, Averdunk L, Kopp R, Stoppe C, Bernhagen J, Pallua N, Bucala R. D-dopachrome tautomerase in adipose tissue inflammation and wound repair. Journal of Cellular and Molecular Medicine. PMID 27605340 DOI: 10.1111/jcmm.12936  0.44
2016 Meza-Romero R, Benedek G, Jordan K, Leng L, Pantouris G, Lolis E, Bucala R, Vandenbark AA. Modeling of both shared and distinct interactions between MIF and its homologue D-DT with their common receptor CD74. Cytokine. 88: 62-70. PMID 27573366 DOI: 10.1016/j.cyto.2016.08.024  0.44
2016 Rowe MA, Harper LR, McNulty MA, Lau AG, Carlson CS, Leng L, Bucala RJ, Miller RA, Loeser RF. Deletion of Macrophage Migration Inhibitory Factor Reduces Severity of Osteoarthritis in Aged Mice. Arthritis & Rheumatology (Hoboken, N.J.). PMID 27564840 DOI: 10.1002/art.39844  0.44
2016 Kim BS, Stoppe C, Grieb G, Leng L, Sauler M, Assis D, Simons D, Boecker AH, Schulte W, Piecychna M, Hager S, Bernhagen J, Pallua N, Bucala R. The clinical significance of the MIF homolog d-dopachrome tautomerase (MIF-2) and its circulating receptor (sCD74) in burn. Burns : Journal of the International Society For Burn Injuries. PMID 27209369 DOI: 10.1016/j.burns.2016.02.005  0.44
2016 Przybyl L, Haase N, Golic M, Rugor J, Solano ME, Arck PC, Gauster M, Huppertz B, Emontzpohl C, Stoppe C, Bernhagen J, Leng L, Bucala R, Schulz H, Heuser A, et al. CD74-Downregulation of Placental Macrophage-Trophoblastic Interactions in Preeclampsia. Circulation Research. PMID 27199465 DOI: 10.1161/CIRCRESAHA.116.308304  0.44
2016 Holowka T, Castilho TM, Garcia AB, Sun T, McMahon-Pratt D, Bucala R. Leishmania-encoded orthologs of macrophage migration inhibitory factor regulate host immunity to promote parasite persistence. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 26956417 DOI: 10.1096/fj.201500189R  0.48
2016 Xu X, Pang J, Chen Y, Bucala R, Zhang Y, Ren J. Macrophage Migration Inhibitory Factor (MIF) Deficiency Exacerbates Aging-Induced Cardiac Remodeling and Dysfunction Despite Improved Inflammation: Role of Autophagy Regulation. Scientific Reports. 6: 22488. PMID 26940544 DOI: 10.1038/srep22488  0.44
2016 Galvão I, Dias AC, Tavares LD, Rodrigues IP, Queiroz-Junior CM, Costa VV, Reis AC, Ribeiro RD, Louzada-Junior P, Souza DG, Leng L, Bucala R, Sousa LP, Bozza MT, Teixeira MM, et al. Macrophage migration inhibitory factor drives neutrophil accumulation by facilitating IL-1β production in a murine model of acute gout. Journal of Leukocyte Biology. PMID 26868525 DOI: 10.1189/jlb.3MA0915-418R  0.44
2016 Meza-Romero R, Benedek G, Leng L, Bucala R, Vandenbark AA. Predicted structure of MIF/CD74 and RTL1000/CD74 complexes. Metabolic Brain Disease. 31: 249-55. PMID 26851955 DOI: 10.1007/s11011-016-9798-x  0.44
2016 Yao J, Leng L, Sauler M, Fu W, Zheng J, Zhang Y, Du X, Yu X, Lee P, Bucala R. Transcription factor ICBP90 regulates the MIF promoter and immune susceptibility locus. The Journal of Clinical Investigation. PMID 26752645 DOI: 10.1172/JCI81937  0.4
2015 Das R, Loughran K, Murchison C, Qian F, Leng L, Song Y, Montgomery RR, Loeb M, Bucala R. Association between high expression macrophage migration inhibitory factor (MIF) alleles and West Nile virus encephalitis. Cytokine. 78: 51-54. PMID 26638028 DOI: 10.1016/j.cyto.2015.11.021  0.44
2015 Hwang SH, Jung SH, Lee S, Choi S, Yoo SA, Park JH, Hwang D, Shim SC, Sabbagh L, Kim KJ, Park SH, Cho CS, Kim BS, Leng L, Montgomery RR, ... Bucala R, et al. Leukocyte-specific protein 1 regulates T-cell migration in rheumatoid arthritis. Proceedings of the National Academy of Sciences of the United States of America. PMID 26554018 DOI: 10.1073/pnas.1514152112  0.44
2015 Li SQ, Yu Y, Han JZ, Wang D, Liu J, Qian F, Fan GH, Bucala R, Ye RD. Deficiency of macrophage migration inhibitory factor attenuates tau hyperphosphorylation in mouse models of Alzheimer's disease. Journal of Neuroinflammation. 12: 177. PMID 26382037 DOI: 10.1186/s12974-015-0396-3  0.4
2015 Pantouris G, Syed MA, Fan C, Rajasekaran D, Cho TY, Rosenberg EM, Bucala R, Bhandari V, Lolis EJ. An Analysis of MIF Structural Features that Control Functional Activation of CD74. Chemistry & Biology. 22: 1197-205. PMID 26364929 DOI: 10.1016/j.chembiol.2015.08.006  0.44
2015 Bay-Richter C, Janelidze S, Sauro A, Bucala R, Lipton J, Deierborg T, Brundin L. Behavioural and neurobiological consequences of macrophage migration inhibitory factor gene deletion in mice. Journal of Neuroinflammation. 12: 163. PMID 26338025 DOI: 10.1186/s12974-015-0387-4  0.4
2015 Stoppe C, Rex S, Goetzenich A, Kraemer S, Emontzpohl C, Soppert J, Sun Y, Rossaint R, Lue H, Averdunk L, Huang C, Song Y, Pantouris G, Lolis E, Leng L, ... ... Bucala R, et al. Interaction of MIF family proteins in myocardial ischemia/reperfusion damage and their influence on clinical outcome of cardiac surgery patients. Antioxidants & Redox Signaling. PMID 26234719 DOI: 10.1089/ars.2014.6243  0.44
2015 Sauler M, Bucala R, Lee PJ. Role of macrophage migration inhibitory factor in age-related lung disease. American Journal of Physiology. Lung Cellular and Molecular Physiology. 309: L1-10. PMID 25957294 DOI: 10.1152/ajplung.00339.2014  0.4
2015 Weiser JN, Roche AM, Hergott CB, LaRose MI, Connolly T, Jorgensen WL, Leng L, Bucala R, Das R. Macrophage Migration Inhibitory Factor Is Detrimental in Pneumococcal Pneumonia and a Target for Therapeutic Immunomodulation. The Journal of Infectious Diseases. PMID 25943202 DOI: 10.1093/infdis/jiv262  0.44
2015 McDevitt MA, Xie J, Ganapathy-Kanniappan S, Griffith J, Liu A, McDonald C, Thuma P, Gordeuk VR, Metz CN, Mitchell R, Keefer J, David J, Leng L, Bucala R. A critical role for the host mediator macrophage migration inhibitory factor in the pathogenesis of malarial anemia. The Journal of Experimental Medicine. 212: 825. PMID 25941322 DOI: 10.1084/jem.2005239804172015c  0.44
2015 Gu R, Santos LL, Ngo D, Fan H, Singh PP, Fingerle-Rowson G, Bucala R, Xu J, Quinn JM, Morand EF. Macrophage migration inhibitory factor is essential for osteoclastogenic mechanisms in vitro and in vivo mouse model of arthritis. Cytokine. 72: 135-45. PMID 25647268 DOI: 10.1016/j.cyto.2014.11.015  0.4
2015 Sauler M, Zhang Y, Min JN, Leng L, Shan P, Roberts S, Jorgensen WL, Bucala R, Lee PJ. Endothelial CD74 mediates macrophage migration inhibitory factor protection in hyperoxic lung injury. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 29: 1940-9. PMID 25609432 DOI: 10.1096/fj.14-260299  0.44
2015 Wu B, Song Y, Leng L, Bucala R, Lu LJ. Treatment of moderate rheumatoid arthritis with different strategies in a health resource-limited setting: a cost-effectiveness analysis in the era of biosimilars. Clinical and Experimental Rheumatology. 33: 20-6. PMID 25438197  0.44
2015 Barnes MA, McMullen MR, Roychowdhury S, Madhun NZ, Niese K, Olman MA, Stavitsky AB, Bucala R, Nagy LE. Macrophage migration inhibitory factor is required for recruitment of scar-associated macrophages during liver fibrosis. Journal of Leukocyte Biology. 97: 161-9. PMID 25398607 DOI: 10.1189/jlb.3A0614-280R  0.44
2015 Bick J, Nguyen V, Leng L, Piecychna M, Crowley MJ, Bucala R, Mayes LC, Grigorenko EL. Preliminary associations between childhood neglect, MIF, and cortisol: potential pathways to long-term disease risk. Developmental Psychobiology. 57: 131-9. PMID 25380347 DOI: 10.1002/dev.21265  0.4
2014 Mawhinney L, Armstrong ME, O' Reilly C, Bucala R, Leng L, Fingerle-Rowson G, Fayne D, Keane MP, Tynan A, Maher L, Cooke G, Lloyd D, Conroy H, Donnelly SC. Macrophage migration inhibitory factor (MIF) enzymatic activity and lung cancer. Molecular Medicine (Cambridge, Mass.). 20: 729-35. PMID 25826675 DOI: 10.2119/molmed.2014.00136  0.44
2014 Pantouris G, Rajasekaran D, Garcia AB, Ruiz VG, Leng L, Jorgensen WL, Bucala R, Lolis EJ. Crystallographic and receptor binding characterization of Plasmodium falciparum macrophage migration inhibitory factor complexed to two potent inhibitors. Journal of Medicinal Chemistry. 57: 8652-6. PMID 25268646 DOI: 10.1021/jm501168q  0.4
2014 Stijlemans B, Leng L, Brys L, Sparkes A, Vansintjan L, Caljon G, Raes G, Van Den Abbeele J, Van Ginderachter JA, Beschin A, Bucala R, De Baetselier P. MIF contributes to Trypanosoma brucei associated immunopathogenicity development. Plos Pathogens. 10: e1004414. PMID 25255103 DOI: 10.1371/journal.ppat.1004414  0.4
2014 Heinrichs D, Berres ML, Coeuru M, Knauel M, Nellen A, Fischer P, Philippeit C, Bucala R, Trautwein C, Wasmuth HE, Bernhagen J. Protective role of macrophage migration inhibitory factor in nonalcoholic steatohepatitis. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 5136-47. PMID 25122558 DOI: 10.1096/fj.14-256776  0.4
2014 Rajasekaran D, Zierow S, Syed M, Bucala R, Bhandari V, Lolis EJ. Targeting distinct tautomerase sites of D-DT and MIF with a single molecule for inhibition of neutrophil lung recruitment. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 4961-71. PMID 25016026 DOI: 10.1096/fj.14-256636  0.4
2014 Qi D, Atsina K, Qu L, Hu X, Wu X, Xu B, Piecychna M, Leng L, Fingerle-Rowson G, Zhang J, Bucala R, Young LH. The vestigial enzyme D-dopachrome tautomerase protects the heart against ischemic injury. The Journal of Clinical Investigation. 124: 3540-50. PMID 24983315 DOI: 10.1172/JCI73061  0.4
2014 Das R, LaRose MI, Hergott CB, Leng L, Bucala R, Weiser JN. Macrophage migration inhibitory factor promotes clearance of pneumococcal colonization. Journal of Immunology (Baltimore, Md. : 1950). 193: 764-72. PMID 24928996 DOI: 10.4049/jimmunol.1400133  0.4
2014 Wang SL, Wu B, Zhu LA, Leng L, Bucala R, Lu LJ. Construct and criterion validity of the Euro Qol-5D in patients with systemic lupus erythematosus. Plos One. 9: e98883. PMID 24892282 DOI: 10.1371/journal.pone.0098883  0.4
2014 Song Y, Zhu LA, Wang SL, Leng L, Bucala R, Lu LJ. Multi-dimensional health assessment questionnaire in China: reliability, validity and clinical value in patients with rheumatoid arthritis. Plos One. 9: e97952. PMID 24848431 DOI: 10.1371/journal.pone.0097952  0.4
2014 Meza-Romero R, Benedek G, Yu X, Mooney JL, Dahan R, Duvshani N, Bucala R, Offner H, Reiter Y, Burrows GG, Vandenbark AA. HLA-DRα1 constructs block CD74 expression and MIF effects in experimental autoimmune encephalomyelitis. Journal of Immunology (Baltimore, Md. : 1950). 192: 4164-73. PMID 24683185 DOI: 10.4049/jimmunol.1303118  0.4
2014 Qu G, Fetterer R, Leng L, Du X, Zarlenga D, Shen Z, Han W, Bucala R, Tuo W. Ostertagia ostertagi macrophage migration inhibitory factor is present in all developmental stages and may cross-regulate host functions through interaction with the host receptor. International Journal For Parasitology. 44: 355-67. PMID 24583184 DOI: 10.1016/j.ijpara.2014.01.009  0.4
2014 White DA, Su Y, Kanellakis P, Kiriazis H, Morand EF, Bucala R, Dart AM, Gao XM, Du XJ. Differential roles of cardiac and leukocyte derived macrophage migration inhibitory factor in inflammatory responses and cardiac remodelling post myocardial infarction. Journal of Molecular and Cellular Cardiology. 69: 32-42. PMID 24508700 DOI: 10.1016/j.yjmcc.2014.01.015  0.4
2014 Fallica J, Boyer L, Kim B, Serebreni L, Varela L, Hamdan O, Wang L, Simms T, Damarla M, Kolb TM, Bucala R, Mitzner W, Hassoun PM, Damico R. Macrophage migration inhibitory factor is a novel determinant of cigarette smoke-induced lung damage. American Journal of Respiratory Cell and Molecular Biology. 51: 94-103. PMID 24490973 DOI: 10.1165/rcmb.2013-0371OC  0.4
2014 Sauler M, Leng L, Trentalange M, Haslip M, Shan P, Piecychna M, Zhang Y, Andrews N, Mannam P, Allore H, Fried T, Bucala R, Lee PJ. Macrophage migration inhibitory factor deficiency in chronic obstructive pulmonary disease. American Journal of Physiology. Lung Cellular and Molecular Physiology. 306: L487-96. PMID 24441872 DOI: 10.1152/ajplung.00284.2013  0.4
2014 Das R, Subrahmanyan L, Yang IV, van Duin D, Levy R, Piecychna M, Leng L, Montgomery RR, Shaw A, Schwartz DA, Bucala R. Functional polymorphisms in the gene encoding macrophage migration inhibitory factor are associated with Gram-negative bacteremia in older adults. The Journal of Infectious Diseases. 209: 764-8. PMID 24158957 DOI: 10.1093/infdis/jit571  0.4
2014 Assis DN, Leng L, Du X, Zhang CK, Grieb G, Merk M, Garcia AB, McCrann C, Chapiro J, Meinhardt A, Mizue Y, Nikolic-Paterson DJ, Bernhagen J, Kaplan MM, Zhao H, ... ... Bucala R, et al. The role of macrophage migration inhibitory factor in autoimmune liver disease. Hepatology (Baltimore, Md.). 59: 580-91. PMID 23913513 DOI: 10.1002/hep.26664  0.4
2013 Herrero LJ, Sheng KC, Jian P, Taylor A, Her Z, Herring BL, Chow A, Leo YS, Hickey MJ, Morand EF, Ng LF, Bucala R, Mahalingam S. Macrophage migration inhibitory factor receptor CD74 mediates alphavirus-induced arthritis and myositis in murine models of alphavirus infection. Arthritis and Rheumatism. 65: 2724-36. PMID 23896945 DOI: 10.1002/art.38090  0.4
2013 Das R, Koo MS, Kim BH, Jacob ST, Subbian S, Yao J, Leng L, Levy R, Murchison C, Burman WJ, Moore CC, Scheld WM, David JR, Kaplan G, MacMicking JD, ... Bucala R, et al. Macrophage migration inhibitory factor (MIF) is a critical mediator of the innate immune response to Mycobacterium tuberculosis. Proceedings of the National Academy of Sciences of the United States of America. 110: E2997-3006. PMID 23882081 DOI: 10.1073/pnas.1301128110  0.4
2013 Qu G, Fetterer R, Jenkins M, Leng L, Shen Z, Murphy C, Han W, Bucala R, Tuo W. Characterization of Neospora caninum macrophage migration inhibitory factor. Experimental Parasitology. 135: 246-56. PMID 23850997 DOI: 10.1016/j.exppara.2013.07.001  0.44
2013 Fan C, Rajasekaran D, Syed MA, Leng L, Loria JP, Bhandari V, Bucala R, Lolis EJ. MIF intersubunit disulfide mutant antagonist supports activation of CD74 by endogenous MIF trimer at physiologic concentrations. Proceedings of the National Academy of Sciences of the United States of America. 110: 10994-9. PMID 23776208 DOI: 10.1073/pnas.1221817110  0.4
2013 Wang J, Tong C, Yan X, Yeung E, Gandavadi S, Hare AA, Du X, Chen Y, Xiong H, Ma C, Leng L, Young LH, Jorgensen WL, Li J, Bucala R. Limiting cardiac ischemic injury by pharmacological augmentation of macrophage migration inhibitory factor-AMP-activated protein kinase signal transduction. Circulation. 128: 225-36. PMID 23753877 DOI: 10.1161/CIRCULATIONAHA.112.000862  0.4
2013 Metodieva G, Nogueira-de-Souza NC, Greenwood C, Al-Janabi K, Leng L, Bucala R, Metodiev MV. CD74-dependent deregulation of the tumor suppressor scribble in human epithelial and breast cancer cells. Neoplasia (New York, N.Y.). 15: 660-8. PMID 23730214 DOI: 10.1593/neo.13464  0.4
2013 Wang FF, Huang XF, Shen N, Leng L, Bucala R, Chen SL, Lu LJ. A genetic role for macrophage migration inhibitory factor (MIF) in adult-onset Still's disease. Arthritis Research & Therapy. 15: R65. PMID 23721694 DOI: 10.1186/ar4239  0.44
2013 Wang SL, Wu B, Leng L, Bucala R, Lu LJ. Validity of LupusQoL-China for the assessment of health related quality of life in Chinese patients with systemic lupus erythematosus. Plos One. 8: e63795. PMID 23717486 DOI: 10.1371/journal.pone.0063795  0.44
2013 Xu X, Pacheco BD, Leng L, Bucala R, Ren J. Macrophage migration inhibitory factor plays a permissive role in the maintenance of cardiac contractile function under starvation through regulation of autophagy. Cardiovascular Research. 99: 412-21. PMID 23674514 DOI: 10.1093/cvr/cvt116  0.44
2013 Sun H, Choo-Wing R, Sureshbabu A, Fan J, Leng L, Yu S, Jiang D, Noble P, Homer RJ, Bucala R, Bhandari V. A critical regulatory role for macrophage migration inhibitory factor in hyperoxia-induced injury in the developing murine lung. Plos One. 8: e60560. PMID 23637753 DOI: 10.1371/journal.pone.0060560  0.44
2013 Benedek G, Meza-Romero R, Andrew S, Leng L, Burrows GG, Bourdette D, Offner H, Bucala R, Vandenbark AA. Partial MHC class II constructs inhibit MIF/CD74 binding and downstream effects. European Journal of Immunology. 43: 1309-21. PMID 23576302 DOI: 10.1002/eji.201243162  0.4
2013 Mathew B, Jacobson JR, Siegler JH, Moitra J, Blasco M, Xie L, Unzueta C, Zhou T, Evenoski C, Al-Sakka M, Sharma R, Huey B, Bulent A, Smith B, Jayaraman S, ... ... Bucala R, et al. Role of migratory inhibition factor in age-related susceptibility to radiation lung injury via NF-E2-related factor-2 and antioxidant regulation. American Journal of Respiratory Cell and Molecular Biology. 49: 269-78. PMID 23526214 DOI: 10.1165/rcmb.2012-0291OC  0.4
2013 Singh A, Leng L, Fan J, Gajda M, Bräuer R, Fingerle-Rowson G, Bucala R, Illges H. Macrophage-derived, macrophage migration inhibitory factor (MIF) is necessary to induce disease in the K/BxN serum-induced model of arthritis. Rheumatology International. 33: 2301-8. PMID 23503937 DOI: 10.1007/s00296-013-2713-4  0.44
2013 Sun H, Choo-Wing R, Fan J, Leng L, Syed MA, Hare AA, Jorgensen WL, Bucala R, Bhandari V. Small molecular modulation of macrophage migration inhibitory factor in the hyperoxia-induced mouse model of bronchopulmonary dysplasia. Respiratory Research. 14: 27. PMID 23448134 DOI: 10.1186/1465-9921-14-27  0.4
2013 Turtzo LC, Li J, Persky R, Benashski S, Weston G, Bucala R, Venna VR, McCullough LD. Deletion of macrophage migration inhibitory factor worsens stroke outcome in female mice. Neurobiology of Disease. 54: 421-31. PMID 23376686 DOI: 10.1016/j.nbd.2013.01.016  0.4
2013 Barnes MA, McMullen MR, Roychowdhury S, Pisano SG, Liu X, Stavitsky AB, Bucala R, Nagy LE. Macrophage migration inhibitory factor contributes to ethanol-induced liver injury by mediating cell injury, steatohepatitis, and steatosis. Hepatology (Baltimore, Md.). 57: 1980-91. PMID 23174952 DOI: 10.1002/hep.26169  0.44
2013 Stoppe C, Werker T, Rossaint R, Dollo F, Lue H, Wonisch W, Menon A, Goetzenich A, Bruells CS, Coburn M, Kopp R, Bucala R, Bernhagen J, Rex S. What is the significance of perioperative release of macrophage migration inhibitory factor in cardiac surgery? Antioxidants & Redox Signaling. 19: 231-9. PMID 23157710 DOI: 10.1089/ars.2012.5015  0.4
2012 Dahlgren MK, Garcia AB, Hare AA, Tirado-Rives J, Leng L, Bucala R, Jorgensen WL. Virtual screening and optimization yield low-nanomolar inhibitors of the tautomerase activity of Plasmodium falciparum macrophage migration inhibitory factor. Journal of Medicinal Chemistry. 55: 10148-59. PMID 23067344 DOI: 10.1021/jm301269s  0.4
2012 Choi S, Kim HR, Leng L, Kang I, Jorgensen WL, Cho CS, Bucala R, Kim WU. Role of macrophage migration inhibitory factor in the regulatory T cell response of tumor-bearing mice. Journal of Immunology (Baltimore, Md. : 1950). 189: 3905-13. PMID 22972922 DOI: 10.4049/jimmunol.1102152  0.4
2012 Russell TM, Herzog EL, Bucala R. Flow cytometric identification of fibrocytes in scleroderma lung disease. Methods in Molecular Biology (Clifton, N.J.). 900: 327-46. PMID 22933077 DOI: 10.1007/978-1-60761-720-4_16  0.4
2012 Bai F, Asojo OA, Cirillo P, Ciustea M, Ledizet M, Aristoff PA, Leng L, Koski RA, Powell TJ, Bucala R, Anthony KG. A novel allosteric inhibitor of macrophage migration inhibitory factor (MIF). The Journal of Biological Chemistry. 287: 30653-63. PMID 22782901 DOI: 10.1074/jbc.M112.385583  0.4
2012 Sun T, Holowka T, Song Y, Zierow S, Leng L, Chen Y, Xiong H, Griffith J, Nouraie M, Thuma PE, Lolis E, Janse CJ, Gordeuk VR, Augustijn K, Bucala R. A Plasmodium-encoded cytokine suppresses T-cell immunity during malaria. Proceedings of the National Academy of Sciences of the United States of America. 109: E2117-26. PMID 22778413 DOI: 10.1073/pnas.1206573109  0.4
2012 Adamali H, Armstrong ME, McLaughlin AM, Cooke G, McKone E, Costello CM, Gallagher CG, Leng L, Baugh JA, Fingerle-Rowson G, Bucala RJ, McLoughlin P, Donnelly SC. Macrophage migration inhibitory factor enzymatic activity, lung inflammation, and cystic fibrosis. American Journal of Respiratory and Critical Care Medicine. 186: 162-9. PMID 22592805 DOI: 10.1164/rccm.201110-1864OC  0.4
2012 Telang S, Clem BF, Klarer AC, Clem AL, Trent JO, Bucala R, Chesney J. Small molecule inhibition of 6-phosphofructo-2-kinase suppresses t cell activation. Journal of Translational Medicine. 10: 95. PMID 22591674 DOI: 10.1186/1479-5876-10-95  0.4
2012 Wang X, Chen T, Leng L, Fan J, Cao K, Duan Z, Zhang X, Shao C, Wu M, Tadmori I, Li T, Liang L, Sun D, Zheng S, Meinhardt A, ... ... Bucala R, et al. MIF produced by bone marrow-derived macrophages contributes to teratoma progression after embryonic stem cell transplantation. Cancer Research. 72: 2867-78. PMID 22461508 DOI: 10.1158/0008-5472.CAN-11-3247  0.44
2012 Mount PF, Gleich K, Tam S, Fraser SA, Choy SW, Dwyer KM, Lu B, Denderen BV, Fingerle-Rowson G, Bucala R, Kemp BE, Power DA. The outcome of renal ischemia-reperfusion injury is unchanged in AMPK-β1 deficient mice. Plos One. 7: e29887. PMID 22253816 DOI: 10.1371/journal.pone.0029887  0.4
2012 Teismann P, Sathe K, Bierhaus A, Leng L, Martin HL, Bucala R, Weigle B, Nawroth PP, Schulz JB. Receptor for advanced glycation endproducts (RAGE) deficiency protects against MPTP toxicity. Neurobiology of Aging. 33: 2478-90. PMID 22227007 DOI: 10.1016/j.neurobiolaging.2011.12.006  0.44
2012 Greenwood C, Metodieva G, Al-Janabi K, Lausen B, Alldridge L, Leng L, Bucala R, Fernandez N, Metodiev MV. Stat1 and CD74 overexpression is co-dependent and linked to increased invasion and lymph node metastasis in triple-negative breast cancer. Journal of Proteomics. 75: 3031-40. PMID 22178447 DOI: 10.1016/j.jprot.2011.11.033  0.44
2012 Cohen S, Shoshana OY, Zelman-Toister E, Maharshak N, Binsky-Ehrenreich I, Gordin M, Hazan-Halevy I, Herishanu Y, Shvidel L, Haran M, Leng L, Bucala R, Harroch S, Shachar I. The cytokine midkine and its receptor RPTPζ regulate B cell survival in a pathway induced by CD74. Journal of Immunology (Baltimore, Md. : 1950). 188: 259-69. PMID 22140262 DOI: 10.4049/jimmunol.1101468  0.4
2012 Qian F, Wang X, Zhang L, Chen S, Piecychna M, Allore H, Bockenstedt L, Malawista S, Bucala R, Shaw AC, Fikrig E, Montgomery RR. Age-associated elevation in TLR5 leads to increased inflammatory responses in the elderly. Aging Cell. 11: 104-10. PMID 22023165 DOI: 10.1111/j.1474-9726.2011.00759.x  0.4
2011 Sreih A, Ezzeddine R, Leng L, LaChance A, Yu G, Mizue Y, Subrahmanyan L, Pons-Estel BA, Abelson AK, Gunnarsson I, Svenungsson E, Cavett J, Glenn S, Zhang L, Montgomery R, ... ... Bucala R, et al. Dual effect of the macrophage migration inhibitory factor gene on the development and severity of human systemic lupus erythematosus. Arthritis and Rheumatism. 63: 3942-51. PMID 22127710 DOI: 10.1002/art.30624  0.44
2011 Heinrichs D, Knauel M, Offermanns C, Berres ML, Nellen A, Leng L, Schmitz P, Bucala R, Trautwein C, Weber C, Bernhagen J, Wasmuth HE. Macrophage migration inhibitory factor (MIF) exerts antifibrotic effects in experimental liver fibrosis via CD74. Proceedings of the National Academy of Sciences of the United States of America. 108: 17444-9. PMID 21969590 DOI: 10.1073/pnas.1107023108  0.4
2011 Cho Y, Vermeire JJ, Merkel JS, Leng L, Du X, Bucala R, Cappello M, Lolis E. Drug repositioning and pharmacophore identification in the discovery of hookworm MIF inhibitors. Chemistry & Biology. 18: 1089-101. PMID 21944748 DOI: 10.1016/j.chembiol.2011.07.011  0.4
2011 Merk M, Zierow S, Leng L, Das R, Du X, Schulte W, Fan J, Lue H, Chen Y, Xiong H, Chagnon F, Bernhagen J, Lolis E, Mor G, Lesur O, ... Bucala R, et al. The D-dopachrome tautomerase (DDT) gene product is a cytokine and functional homolog of macrophage migration inhibitory factor (MIF). Proceedings of the National Academy of Sciences of the United States of America. 108: E577-85. PMID 21817065 DOI: 10.1073/pnas.1102941108  0.4
2011 Jorgensen WL, Trofimov A, Du X, Hare AA, Leng L, Bucala R. Benzisothiazolones as modulators of macrophage migration inhibitory factor. Bioorganic & Medicinal Chemistry Letters. 21: 4545-9. PMID 21719283 DOI: 10.1016/j.bmcl.2011.05.127  0.4
2011 Peng X, Mathai SK, Murray LA, Russell T, Reilkoff R, Chen Q, Gulati M, Elias JA, Bucala R, Gan Y, Herzog EL. Local apoptosis promotes collagen production by monocyte-derived cells in transforming growth factor β1-induced lung fibrosis. Fibrogenesis & Tissue Repair. 4: 12. PMID 21586112 DOI: 10.1186/1755-1536-4-12  0.4
2011 Das R, Moss JE, Robinson E, Roberts S, Levy R, Mizue Y, Leng L, McDonald C, Tigelaar RE, Herrick CA, Bucala R. Role of macrophage migration inhibitory factor in the Th2 immune response to epicutaneous sensitization. Journal of Clinical Immunology. 31: 666-80. PMID 21559932 DOI: 10.1007/s10875-011-9541-7  0.4
2011 Malu DT, Bélanger B, Desautels F, Kelendji K, Dalko E, Sanchez-Dardon J, Leng L, Bucala R, Satoskar AR, Scorza T. Macrophage migration inhibitory factor: a downregulator of early T cell-dependent IFN-gamma responses in Plasmodium chabaudi adami (556 KA)-infected mice. Journal of Immunology (Baltimore, Md. : 1950). 186: 6271-9. PMID 21518974 DOI: 10.4049/jimmunol.1003355  0.44
2011 Gan Y, Reilkoff R, Peng X, Russell T, Chen Q, Mathai SK, Homer R, Gulati M, Siner J, Elias J, Bucala R, Herzog E. Role of semaphorin 7a signaling in transforming growth factor β1-induced lung fibrosis and scleroderma-related interstitial lung disease. Arthritis and Rheumatism. 63: 2484-94. PMID 21484765 DOI: 10.1002/art.30386  0.4
2011 Fan H, Hall P, Santos LL, Gregory JL, Fingerle-Rowson G, Bucala R, Morand EF, Hickey MJ. Macrophage migration inhibitory factor and CD74 regulate macrophage chemotactic responses via MAPK and Rho GTPase. Journal of Immunology (Baltimore, Md. : 1950). 186: 4915-24. PMID 21411731 DOI: 10.4049/jimmunol.1003713  0.4
2009 Griffith JW, Sun T, McIntosh MT, Bucala R. Pure Hemozoin is inflammatory in vivo and activates the NALP3 inflammasome via release of uric acid. Journal of Immunology (Baltimore, Md. : 1950). 183: 5208-20. PMID 19783673 DOI: 10.4049/jimmunol.0713552  0.48
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