Sylvain Meloche - Publications

Université de Montréal, Montréal, Canada 
Microbiology Biology, Pharmacy

45 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Soulez M, Saba-El-Leil MK, Turgeon B, Mathien S, Coulombe P, Klinger S, Rousseau J, Lévesque K, Meloche S. Reevaluation of the Role of ERK3 in Perinatal Survival and Post-Natal Growth Using New Genetically-Engineered Mouse Models. Molecular and Cellular Biology. PMID 30642949 DOI: 10.1128/MCB.00527-18  0.4
2017 Pyakurel A, Balmer D, Saba-El-Leil MK, Kizilyaprak C, Daraspe J, Humbel BM, Voisin L, Le YZ, von Lintig J, Meloche S, Roduit R. Loss of ERK1/2 in the retinal pigment epithelium leads to RPE65 decrease and retinal degeneration. Molecular and Cellular Biology. PMID 29038159 DOI: 10.1128/MCB.00295-17  0.4
2017 Mathien S, Déléris P, Soulez M, Voisin L, Meloche S. The Deubiquitinating Enzyme USP20 Regulates ERK3 Stability and Biological Activity. Molecular and Cellular Biology. PMID 28167606 DOI: 10.1128/MCB.00432-16  0.4
2016 Duhamel S, Girondel C, Dorn JF, Tanguay PL, Voisin L, Smits R, Maddox PS, Meloche S. Deregulated ERK1/2 MAP kinase signaling promotes aneuploidy by a Fbxw7β-Aurora A pathway. Cell Cycle (Georgetown, Tex.). 0. PMID 27152455 DOI: 10.1080/15384101.2016.1183851  0.48
2015 Grote D, Moison C, Duhamel S, Chagraoui J, Girard S, Yang J, Mayotte N, Coulombe Y, Masson JY, Brown GW, Meloche S, Sauvageau G. E4F1 is a master regulator of CHK1-mediated functions. Cell Reports. 11: 210-9. PMID 25843717 DOI: 10.1016/j.celrep.2015.03.019  0.4
2014 Bordeleau ME, Aucagne R, Chagraoui J, Girard S, Mayotte N, Bonneil E, Thibault P, Pabst C, Bergeron A, Barabé F, Hébert J, Sauvageau M, Boutonnet C, Meloche S, Sauvageau G. UBAP2L is a novel BMI1-interacting protein essential for hematopoietic stem cell activity. Blood. 124: 2362-9. PMID 25185265 DOI: 10.1182/blood-2014-01-548651  0.4
2014 Redwan IN, Dyrager C, Solano C, Fernández de Trocóniz G, Voisin L, Bliman D, Meloche S, Grøtli M. Towards the development of chromone-based MEK1/2 modulators. European Journal of Medicinal Chemistry. 85: 127-38. PMID 25078316 DOI: 10.1016/j.ejmech.2014.07.018  0.4
2013 Courcelles M, Frémin C, Voisin L, Lemieux S, Meloche S, Thibault P. Phosphoproteome dynamics reveal novel ERK1/2 MAP kinase substrates with broad spectrum of functions. Molecular Systems Biology. 9: 669. PMID 23712012 DOI: 10.1038/msb.2013.25  0.4
2012 van Zuylen WJ, Doyon P, Clément JF, Khan KA, D'Ambrosio LM, Dô F, St-Amant-Verret M, Wissanji T, Emery G, Gingras AC, Meloche S, Servant MJ. Proteomic profiling of the TRAF3 interactome network reveals a new role for the ER-to-Golgi transport compartments in innate immunity. Plos Pathogens. 8: e1002747. PMID 22792062 DOI: 10.1371/journal.ppat.1002747  0.44
2012 Duhamel S, Hébert J, Gaboury L, Bouchard A, Simon R, Sauter G, Basik M, Meloche S. Sef downregulation by Ras causes MEK1/2 to become aberrantly nuclear localized leading to polyploidy and neoplastic transformation. Cancer Research. 72: 626-35. PMID 22298595 DOI: 10.1158/0008-5472.CAN-11-2126  0.4
2011 Courcelles M, Lemieux S, Voisin L, Meloche S, Thibault P. ProteoConnections: a bioinformatics platform to facilitate proteome and phosphoproteome analyses. Proteomics. 11: 2654-71. PMID 21630457 DOI: 10.1002/pmic.201000776  0.4
2011 Déléris P, Trost M, Topisirovic I, Tanguay PL, Borden KL, Thibault P, Meloche S. Activation loop phosphorylation of ERK3/ERK4 by group I p21-activated kinases (PAKs) defines a novel PAK-ERK3/4-MAPK-activated protein kinase 5 signaling pathway. The Journal of Biological Chemistry. 286: 6470-8. PMID 21177870 DOI: 10.1074/jbc.M110.181529  0.48
2010 Voisin L, Saba-El-Leil MK, Julien C, Frémin C, Meloche S. Genetic demonstration of a redundant role of extracellular signal-regulated kinase 1 (ERK1) and ERK2 mitogen-activated protein kinases in promoting fibroblast proliferation. Molecular and Cellular Biology. 30: 2918-32. PMID 20368360 DOI: 10.1128/MCB.00131-10  0.4
2010 Tanguay PL, Rodier G, Meloche S. C-terminal domain phosphorylation of ERK3 controlled by Cdk1 and Cdc14 regulates its stability in mitosis. The Biochemical Journal. 428: 103-11. PMID 20236090 DOI: 10.1042/BJ20091604  0.48
2010 Boutonnet C, Tanguay PL, Julien C, Rodier G, Coulombe P, Meloche S. Phosphorylation of Ser72 does not regulate the ubiquitin ligase activity and subcellular localization of Skp2. Cell Cycle (Georgetown, Tex.). 9: 975-9. PMID 20160482 DOI: 10.4161/cc.9.5.10915  0.48
2009 Coulombe P, Rodier G, Meloche S. [Cdc14B/Skp2/p27 : a novel cancer axis of evil?]. MéDecine Sciences : M/S. 25: 673-5. PMID 19765377 DOI: 10.1051/medsci/2009258-9673  0.48
2009 White M, Ross H, Levesque S, Whittom L, Pelletier GB, Racine N, Meloche S, Voisin L. Effects of angiotensin-converting enzyme inhibitor versus valsartan on cellular signaling events in heart transplant. The Annals of Pharmacotherapy. 43: 831-9. PMID 19417110 DOI: 10.1345/aph.1L602  0.4
2009 Granados DP, Tanguay PL, Hardy MP, Caron E, de Verteuil D, Meloche S, Perreault C. ER stress affects processing of MHC class I-associated peptides. Bmc Immunology. 10: 10. PMID 19220912 DOI: 10.1186/1471-2172-10-10  0.48
2008 Clément JF, Meloche S, Servant MJ. The IKK-related kinases: from innate immunity to oncogenesis. Cell Research. 18: 889-99. PMID 19160540 DOI: 10.1038/cr.2008.273  0.44
2008 Voisin L, Julien C, Duhamel S, Gopalbhai K, Claveau I, Saba-El-Leil MK, Rodrigue-Gervais IG, Gaboury L, Lamarre D, Basik M, Meloche S. Activation of MEK1 or MEK2 isoform is sufficient to fully transform intestinal epithelial cells and induce the formation of metastatic tumors. Bmc Cancer. 8: 337. PMID 19014680 DOI: 10.1186/1471-2407-8-337  1
2008 Déléris P, Rousseau J, Coulombe P, Rodier G, Tanguay PL, Meloche S. Activation loop phosphorylation of the atypical MAP kinases ERK3 and ERK4 is required for binding, activation and cytoplasmic relocalization of MK5. Journal of Cellular Physiology. 217: 778-88. PMID 18720373 DOI: 10.1002/jcp.21560  0.48
2008 Clément JF, Bibeau-Poirier A, Gravel SP, Grandvaux N, Bonneil E, Thibault P, Meloche S, Servant MJ. Phosphorylation of IRF-3 on Ser 339 generates a hyperactive form of IRF-3 through regulation of dimerization and CBP association. Journal of Virology. 82: 3984-96. PMID 18272581 DOI: 10.1128/JVI.02526-07  0.44
2008 Rodier G, Coulombe P, Tanguay PL, Boutonnet C, Meloche S. Phosphorylation of Skp2 regulated by CDK2 and Cdc14B protects it from degradation by APC(Cdh1) in G1 phase. The Embo Journal. 27: 679-91. PMID 18239684 DOI: 10.1038/emboj.2008.6  0.48
2007 Coulombe P, Meloche S. Atypical mitogen-activated protein kinases: structure, regulation and functions. Biochimica Et Biophysica Acta. 1773: 1376-87. PMID 17161475 DOI: 10.1016/j.bbamcr.2006.11.001  0.4
2006 Bibeau-Poirier A, Gravel SP, Clément JF, Rolland S, Rodier G, Coulombe P, Hiscott J, Grandvaux N, Meloche S, Servant MJ. Involvement of the IkappaB kinase (IKK)-related kinases tank-binding kinase 1/IKKi and cullin-based ubiquitin ligases in IFN regulatory factor-3 degradation. Journal of Immunology (Baltimore, Md. : 1950). 177: 5059-67. PMID 17015689  0.48
2006 Chagraoui J, Niessen SL, Lessard J, Girard S, Coulombe P, Sauvageau M, Meloche S, Sauvageau G. E4F1: a novel candidate factor for mediating BMI1 function in primitive hematopoietic cells. Genes & Development. 20: 2110-20. PMID 16882984 DOI: 10.1101/gad.1453406  0.4
2005 Pelletier S, Julien C, Popoff MR, Lamarche-Vane N, Meloche S. Cyclic AMP induces morphological changes of vascular smooth muscle cells by inhibiting a Rac-dependent signaling pathway. Journal of Cellular Physiology. 204: 412-22. PMID 15706595 DOI: 10.1002/jcp.20308  0.44
2005 Rodier G, Makris C, Coulombe P, Scime A, Nakayama K, Nakayama KI, Meloche S. p107 inhibits G1 to S phase progression by down-regulating expression of the F-box protein Skp2. The Journal of Cell Biology. 168: 55-66. PMID 15631990 DOI: 10.1083/jcb.200404146  0.48
2004 Coulombe P, Rodier G, Bonneil E, Thibault P, Meloche S. N-Terminal ubiquitination of extracellular signal-regulated kinase 3 and p21 directs their degradation by the proteasome. Molecular and Cellular Biology. 24: 6140-50. PMID 15226418 DOI: 10.1128/MCB.24.14.6140-6150.2004  0.48
2004 Lips DJ, Bueno OF, Wilkins BJ, Purcell NH, Kaiser RA, Lorenz JN, Voisin L, Saba-El-Leil MK, Meloche S, Pouysségur J, Pagès G, De Windt LJ, Doevendans PA, Molkentin JD. MEK1-ERK2 signaling pathway protects myocardium from ischemic injury in vivo. Circulation. 109: 1938-41. PMID 15096454 DOI: 10.1161/01.CIR.0000127126.73759.23  0.4
2004 Meloche S, Vella FD, Voisin L, Ang SL, Saba-El-Leil M. Erk2 signaling and early embryo stem cell self-renewal. Cell Cycle (Georgetown, Tex.). 3: 241-3. PMID 14726711  0.4
2003 Saba-El-Leil MK, Vella FD, Vernay B, Voisin L, Chen L, Labrecque N, Ang SL, Meloche S. An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development. Embo Reports. 4: 964-8. PMID 14502223 DOI: 10.1038/sj.embor.embor939  0.4
2003 Julien C, Coulombe P, Meloche S. Nuclear export of ERK3 by a CRM1-dependent mechanism regulates its inhibitory action on cell cycle progression. The Journal of Biological Chemistry. 278: 42615-24. PMID 12915405 DOI: 10.1074/jbc.M302724200  0.4
2003 Coulombe P, Rodier G, Pelletier S, Pellerin J, Meloche S. Rapid turnover of extracellular signal-regulated kinase 3 by the ubiquitin-proteasome pathway defines a novel paradigm of mitogen-activated protein kinase regulation during cellular differentiation. Molecular and Cellular Biology. 23: 4542-58. PMID 12808096  0.48
2003 Gingras B, Rodier G, Giasson E, Coulombe P, Chassagne C, Meloche S. Expression of angiotensin type II receptor downregulates Cdk4 synthesis and inhibits cell-cycle progression. Oncogene. 22: 2633-42. PMID 12730677 DOI: 10.1038/sj.onc.1206346  0.48
2003 Pelletier S, Duhamel F, Coulombe P, Popoff MR, Meloche S. Rho family GTPases are required for activation of Jak/STAT signaling by G protein-coupled receptors. Molecular and Cellular Biology. 23: 1316-33. PMID 12556491  0.44
2003 Gopalbhai K, Jansen G, Beauregard G, Whiteway M, Dumas F, Wu C, Meloche S. Negative regulation of MAPKK by phosphorylation of a conserved serine residue equivalent to Ser212 of MEK1. The Journal of Biological Chemistry. 278: 8118-25. PMID 12506122 DOI: 10.1074/jbc.M211870200  1
2002 Coulombe P, Meloche S. Dual-tag prokaryotic vectors for enhanced expression of full-length recombinant proteins. Analytical Biochemistry. 310: 219-22. PMID 12423642  0.4
2002 Makris C, Voisin L, Giasson E, Tudan C, Kaplan DR, Meloche S. The Rb-family protein p107 inhibits translation by a PDK1-dependent mechanism. Oncogene. 21: 7891-6. PMID 12420226 DOI: 10.1038/sj.onc.1205964  0.4
2002 Voisin L, Foisy S, Giasson E, Lambert C, Moreau P, Meloche S. EGF receptor transactivation is obligatory for protein synthesis stimulation by G protein-coupled receptors. American Journal of Physiology. Cell Physiology. 283: C446-55. PMID 12107054 DOI: 10.1152/ajpcell.00261.2001  0.4
2001 Rouleau JL, Kapuku G, Pelletier S, Gosselin H, Adam A, Gagnon C, Lambert C, Meloche S. Cardioprotective effects of ramipril and losartan in right ventricular pressure overload in the rabbit: importance of kinins and influence on angiotensin II type 1 receptor signaling pathway. Circulation. 104: 939-44. PMID 11514383  0.44
2000 Meloche S, Pelletier S, Servant MJ. Functional cross-talk between the cyclic AMP and Jak/STAT signaling pathways in vascular smooth muscle cells. Molecular and Cellular Biochemistry. 212: 99-109. PMID 11108141  0.44
2000 Meloche S, Gopalbhai K, Beatty BG, Scherer SW, Pellerin J. Chromosome mapping of the human genes encoding the MAP kinase kinase MEK1 (MAP2K1) to 15q21 and MEK2 (MAP2K2) to 7q32. Cytogenetics and Cell Genetics. 88: 249-52. PMID 10828601  1
1998 Gopalbhai K, Meloche S. Repression of mitogen-activated protein kinases ERK1/ERK2 activity by a protein tyrosine phosphatase in rat fibroblasts transformed by upstream oncoproteins. Journal of Cellular Physiology. 174: 35-47. PMID 9397154 DOI: 10.1002/(SICI)1097-4652(199801)174:1<35::AID-JCP5>3.0.CO;2-H  1
1996 Rajotte D, Sadowski HB, Haman A, Gopalbhai K, Meloche S, Liu L, Krystal G, Hoang T. Contribution of both STAT and SRF/TCF to c-fos promoter activation by granulocyte-macrophage colony-stimulating factor. Blood. 88: 2906-16. PMID 8874187  1
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