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Eric S. Huseby, Ph.D. - Publications

Affiliations: 
2000 University of Washington, Seattle, Seattle, WA 
Area:
Immunology
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52 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Yin R, Melton S, Huseby ES, Kardar M, Chakraborty AK. How persistent infection overcomes peripheral tolerance mechanisms to cause T cell-mediated autoimmune disease. Proceedings of the National Academy of Sciences of the United States of America. 121: e2318599121. PMID 38446856 DOI: 10.1073/pnas.2318599121  0.571
2023 Stadinski BD, Cleveland SB, Brehm MA, Greiner DL, Huseby PG, Huseby ES. I-A β56/57 polymorphisms regulate non-cognate negative selection to CD4 T cell orchestrators of type 1 diabetes. Nature Immunology. PMID 36807641 DOI: 10.1038/s41590-023-01441-0  0.742
2022 Huseby ES, Teixeiro E. The perception and response of T cells to a changing environment are based on the law of initial value. Science Signaling. 15: eabj9842. PMID 35639856 DOI: 10.1126/scisignal.abj9842  0.543
2020 Cleveland SB, Huseby ES. Resolving the Instructions for αβ T Cell Development. Immunity. 53: 1126-1128. PMID 33326761 DOI: 10.1016/j.immuni.2020.11.014  0.755
2020 Spidale NA, Malhotra N, Frascoli M, Sylvia K, Miu B, Freeman C, Stadinski BD, Huseby E, Kang J. Neonatal-derived IL-17 producing dermal γδ T cells are required to prevent spontaneous atopic dermatitis. Elife. 9. PMID 32065580 DOI: 10.7554/Elife.51188  0.441
2020 Spidale NA, Malhotra N, Frascoli M, Sylvia K, Miu B, Freeman C, Stadinski BD, Huseby E, Kang J. Author response: Neonatal-derived IL-17 producing dermal γδ T cells are required to prevent spontaneous atopic dermatitis Elife. DOI: 10.7554/Elife.51188.Sa2  0.468
2019 Stadinski BD, Blevins SJ, Spidale NA, Duke BR, Huseby PG, Stern LJ, Huseby ES. A temporal thymic selection switch and ligand binding kinetics constrain neonatal Foxp3 T cell development. Nature Immunology. PMID 31209405 DOI: 10.1038/s41590-019-0414-1  0.555
2019 Stadinski BD, Blevins SJ, Spidale NA, Duke BR, Huseby PG, Stern LJ, Huseby ES. A temporal thymic selection switch and ligand binding kinetics constrain neonatal Foxp3+Tregcell development. Nature Immunology. 20: 1046-1058. DOI: 10.2210/Pdb6Mno/Pdb  0.598
2018 Rowe JH, Delmonte OM, Keles S, Stadinski BD, Dobbs AK, Henderson LA, Yamazaki Y, Allende LM, Bonilla FA, Gonzalez-Granado LI, Celikbilek Celik S, Guner SN, Kapakli H, Yee C, Pai SY, ... Huseby ES, et al. Patients with mutations reveal a role for human CD3γ in T diversity and suppressive function. Blood. PMID 29653965 DOI: 10.1182/Blood-2018-02-835561  0.675
2017 Blevins S, Huseby ES. Killer T cells with a beta-flavi(r) for dengue. Nature Immunology. 18: 1186-1188. PMID 29044243 DOI: 10.1038/Ni.3833  0.635
2017 Rowe JH, Stadinski BD, Henderson LA, de Bruin LO, Delmonte O, Lee YN, Teresa de la Morena M, Goyal RK, Hayward A, Chiung-Hui H, Kanariou M, King A, Kuijpers TW, Soh JY, Neven B, ... ... Huseby ES, et al. Abnormalities of T cell receptor repertoire in CD4(+) regulatory and conventional T cells in patients with RAG mutations: implications for autoimmunity. The Journal of Allergy and Clinical Immunology. PMID 28864286 DOI: 10.1016/J.Jaci.2017.08.001  0.665
2016 Wyss L, Stadinski BD, King CG, Schallenberg S, McCarthy NI, Lee JY, Kretschmer K, Terracciano LM, Anderson G, Surh CD, Huseby ES, Palmer E. Affinity for self antigen selects Treg cells with distinct functional properties. Nature Immunology. PMID 27478940 DOI: 10.1038/Ni.3522  0.662
2016 Stadinski BD, Shekhar K, Gómez-Touriño I, Jung J, Sasaki K, Sewell AK, Peakman M, Chakraborty AK, Huseby ES. Hydrophobic CDR3 residues promote the development of self-reactive T cells. Nature Immunology. PMID 27348411 DOI: 10.1038/Ni.3491  0.65
2016 Stadinski BD, Obst R, Huseby ES. A 'hotspot' for autoimmune T cells in type 1 diabetes. The Journal of Clinical Investigation. PMID 27183386 DOI: 10.1172/Jci88165  0.644
2015 Huseby ES, Kamimura D, Arima Y, Parello CS, Sasaki K, Murakami M. Role of T cell-glial cell interactions in creating and amplifying central nervous system inflammation and multiple sclerosis disease symptoms. Frontiers in Cellular Neuroscience. 9: 295. PMID 26300731 DOI: 10.3389/Fncel.2015.00295  0.522
2015 Parello CS, Huseby ES. Indoctrinating T cells to attack pathogens through homeschooling. Trends in Immunology. 36: 337-43. PMID 25979654 DOI: 10.1016/J.It.2015.04.004  0.623
2015 Attaf M, Huseby E, Sewell AK. αβ T cell receptors as predictors of health and disease. Cellular & Molecular Immunology. 12: 391-9. PMID 25619506 DOI: 10.1038/Cmi.2014.134  0.555
2014 Stepanek O, Prabhakar AS, Osswald C, King CG, Bulek A, Naeher D, Beaufils-Hugot M, Abanto ML, Galati V, Hausmann B, Lang R, Cole DK, Huseby ES, Sewell AK, Chakraborty AK, et al. Coreceptor scanning by the T cell receptor provides a mechanism for T cell tolerance. Cell. 159: 333-45. PMID 25284152 DOI: 10.1016/J.Cell.2014.08.042  0.648
2014 Keck S, Schmaler M, Ganter S, Wyss L, Oberle S, Huseby ES, Zehn D, King CG. Antigen affinity and antigen dose exert distinct influences on CD4 T-cell differentiation. Proceedings of the National Academy of Sciences of the United States of America. 111: 14852-7. PMID 25267612 DOI: 10.1073/Pnas.1403271111  0.678
2014 Stadinski BD, Huseby ES. Identifying environmental antigens that activate myelin-specific T cells. Trends in Immunology. 35: 231-2. PMID 24820694 DOI: 10.1016/J.It.2014.04.004  0.597
2014 Stadinski BD, Trenh P, Duke B, Huseby PG, Li G, Stern LJ, Huseby ES. Effect of CDR3 sequences and distal V gene residues in regulating TCR-MHC contacts and ligand specificity. Journal of Immunology (Baltimore, Md. : 1950). 192: 6071-82. PMID 24813203 DOI: 10.4049/Jimmunol.1303209  0.515
2014 Sasaki K, Bean A, Shah S, Schutten E, Huseby PG, Peters B, Shen ZT, Vanguri V, Liggitt D, Huseby ES. Relapsing-remitting central nervous system autoimmunity mediated by GFAP-specific CD8 T cells. Journal of Immunology (Baltimore, Md. : 1950). 192: 3029-42. PMID 24591371 DOI: 10.4049/Jimmunol.1302911  0.666
2013 Tubo NJ, Pagán AJ, Taylor JJ, Nelson RW, Linehan JL, Ertelt JM, Huseby ES, Way SS, Jenkins MK. Single naive CD4+ T cells from a diverse repertoire produce different effector cell types during infection. Cell. 153: 785-96. PMID 23663778 DOI: 10.1016/J.Cell.2013.04.007  0.622
2013 Vanguri V, Govern CC, Smith R, Huseby ES. Viral antigen density and confinement time regulate the reactivity pattern of CD4 T-cell responses to vaccinia virus infection. Proceedings of the National Academy of Sciences of the United States of America. 110: 288-93. PMID 23248307 DOI: 10.1073/Pnas.1208328110  0.586
2012 Huseby ES, Huseby PG, Shah S, Smith R, Stadinski BD. Pathogenic CD8 T cells in multiple sclerosis and its experimental models. Frontiers in Immunology. 3: 64. PMID 22566945 DOI: 10.3389/Fimmu.2012.00064  0.669
2012 Hsu CJ, Hsieh WT, Waldman A, Clarke F, Huseby ES, Burkhardt JK, Baumgart T. Ligand mobility modulates immunological synapse formation and T cell activation. Plos One. 7: e32398. PMID 22384241 DOI: 10.1371/Journal.Pone.0032398  0.507
2011 Stadinski BD, Trenh P, Smith RL, Bautista B, Huseby PG, Li G, Stern LJ, Huseby ES. A role for differential variable gene pairing in creating T cell receptors specific for unique major histocompatibility ligands. Immunity. 35: 694-704. PMID 22101158 DOI: 10.1016/J.Immuni.2011.10.012  0.414
2011 Yin L, Huseby E, Scott-Browne J, Rubtsova K, Pinilla C, Crawford F, Marrack P, Dai S, Kappler JW. A single T cell receptor bound to major histocompatibility complex class I and class II glycoproteins reveals switchable TCR conformers. Immunity. 35: 23-33. PMID 21683626 DOI: 10.1016/J.Immuni.2011.04.017  0.429
2010 Wucherpfennig KW, Gagnon E, Call MJ, Huseby ES, Call ME. Structural biology of the T-cell receptor: insights into receptor assembly, ligand recognition, and initiation of signaling. Cold Spring Harbor Perspectives in Biology. 2: a005140. PMID 20452950 DOI: 10.1101/Cshperspect.A005140  0.386
2010 Govern CC, Paczosa MK, Chakraborty AK, Huseby ES. Fast on-rates allow short dwell time ligands to activate T cells. Proceedings of the National Academy of Sciences of the United States of America. 107: 8724-9. PMID 20421471 DOI: 10.1073/Pnas.1000966107  0.554
2008 Kosmrlj A, Jha AK, Huseby ES, Kardar M, Chakraborty AK. How the thymus designs antigen-specific and self-tolerant T cell receptor sequences. Proceedings of the National Academy of Sciences of the United States of America. 105: 16671-6. PMID 18946038 DOI: 10.1073/Pnas.0808081105  0.643
2008 Teague RM, Greenberg PD, Fowler C, Huang MZ, Tan X, Morimoto J, Dossett ML, Huseby ES, Ohlén C. Peripheral CD8+ T cell tolerance to self-proteins is regulated proximally at the T cell receptor. Immunity. 28: 662-74. PMID 18424189 DOI: 10.1016/J.Immuni.2008.03.012  0.653
2008 Dai S, Huseby ES, Rubtsova K, Scott-Browne J, Crawford F, Macdonald WA, Marrack P, Kappler JW. Crossreactive T Cells spotlight the germline rules for alphabeta T cell-receptor interactions with MHC molecules. Immunity. 28: 324-34. PMID 18308592 DOI: 10.1016/J.Immuni.2008.01.008  0.484
2008 Huseby ES, Kappler JW, Marrack P. Thymic selection stifles TCR reactivity with the main chain structure of MHC and forces interactions with the peptide side chains. Molecular Immunology. 45: 599-606. PMID 17920446 DOI: 10.1016/J.Molimm.2006.03.025  0.512
2007 Nishihara M, Ogura H, Ueda N, Tsuruoka M, Kitabayashi C, Tsuji F, Aono H, Ishihara K, Huseby E, Betz UA, Murakami M, Hirano T. IL-6-gp130-STAT3 in T cells directs the development of IL-17+ Th with a minimum effect on that of Treg in the steady state. International Immunology. 19: 695-702. PMID 17493959 DOI: 10.1093/Intimm/Dxm045  0.492
2007 Cabbage SE, Huseby ES, Sather BD, Brabb T, Liggitt D, Goverman J. Regulatory T cells maintain long-term tolerance to myelin basic protein by inducing a novel, dynamic state of T cell tolerance. Journal of Immunology (Baltimore, Md. : 1950). 178: 887-96. PMID 17202350 DOI: 10.4049/Jimmunol.178.2.887  0.722
2006 Huseby ES, Crawford F, White J, Marrack P, Kappler JW. Interface-disrupting amino acids establish specificity between T cell receptors and complexes of major histocompatibility complex and peptide. Nature Immunology. 7: 1191-9. PMID 17041605 DOI: 10.1038/Ni1401  0.362
2006 Crawford F, Jordan KR, Stadinski B, Wang Y, Huseby E, Marrack P, Slansky JE, Kappler JW. Use of baculovirus MHC/peptide display libraries to characterize T-cell receptor ligands. Immunological Reviews. 210: 156-70. PMID 16623770 DOI: 10.1111/J.0105-2896.2006.00365.X  0.399
2005 Huseby ES, White J, Crawford F, Vass T, Becker D, Pinilla C, Marrack P, Kappler JW. How the T cell repertoire becomes peptide and MHC specific. Cell. 122: 247-60. PMID 16051149 DOI: 10.1016/J.Cell.2005.05.013  0.588
2005 Goverman J, Perchellet A, Huseby ES. The role of CD8(+) T cells in multiple sclerosis and its animal models. Current Drug Targets. Inflammation and Allergy. 4: 239-45. PMID 15853746 DOI: 10.2174/1568010053586264  0.79
2004 Huseby E, Kappler J, Marrack P. TCR-MHC/peptide interactions: kissing-cousins or a shotgun wedding? European Journal of Immunology. 34: 1243-50. PMID 15114657 DOI: 10.1002/Eji.200425000  0.365
2004 Crawford F, Huseby E, White J, Marrack P, Kappler JW. Mimotopes for alloreactive and conventional T cells in a peptide-MHC display library. Plos Biology. 2: E90. PMID 15094798 DOI: 10.1371/Journal.Pbio.0020090  0.389
2003 Huseby ES, Crawford F, White J, Kappler J, Marrack P. Negative selection imparts peptide specificity to the mature T cell repertoire. Proceedings of the National Academy of Sciences of the United States of America. 100: 11565-70. PMID 14504410 DOI: 10.1073/Pnas.1934636100  0.534
2002 Ohlén C, Kalos M, Cheng LE, Shur AC, Hong DJ, Carson BD, Kokot NC, Lerner CG, Sather BD, Huseby ES, Greenberg PD. CD8(+) T cell tolerance to a tumor-associated antigen is maintained at the level of expansion rather than effector function. The Journal of Experimental Medicine. 195: 1407-18. PMID 12045239 DOI: 10.1084/Jem.20011063  0.69
2001 Huseby ES, Liggitt D, Brabb T, Schnabel B, Ohlén C, Goverman J. A pathogenic role for myelin-specific CD8(+) T cells in a model for multiple sclerosis. The Journal of Experimental Medicine. 194: 669-76. PMID 11535634 DOI: 10.1084/Jem.194.5.669  0.809
2001 Huseby ES, Sather B, Huseby PG, Goverman J. Age-dependent T cell tolerance and autoimmunity to myelin basic protein. Immunity. 14: 471-81. PMID 11336692 DOI: 10.1016/S1074-7613(01)00127-3  0.797
2000 Bernhard H, Huseby ES, Hand SL, Lohmann M, Batten WY, Disis ML, Gralow JR, Meyer zum Büschenfelde KH, Ohlén C, Cheever MA. Dendritic cells lose ability to present protein antigen after stimulating antigen-specific T cell responses, despite upregulation of MHC class II expression. Immunobiology. 201: 568-82. PMID 10834314 DOI: 10.1016/S0171-2985(00)80075-3  0.628
2000 Huseby ES, Goverman J. Tolerating the nervous system: a delicate balance. The Journal of Experimental Medicine. 191: 757-60. PMID 10704457 DOI: 10.1084/Jem.191.5.757  0.74
1997 Hand SL, Bernhard H, Huseby ES, Rubin WD, Disis ML, Cheever MA. In vitro priming to tumor-associated proteins. Advances in Experimental Medicine and Biology. 417: 503-9. PMID 9286411 DOI: 10.1007/978-1-4757-9966-8_83  0.401
1997 Goverman J, Brabb T, Huseby ES, Farr AG. TCR signaling regulates thymic organization: lessons from TCR-transgenic mice. Immunology Today. 18: 204-8. PMID 9153949 DOI: 10.1016/S0167-5699(97)01055-4  0.751
1997 Brabb T, Huseby ES, Morgan TM, Sant'Angelo DB, Kirchner J, Farr AG, Goverman J. Thymic stromal organization is regulated by the specificity of T cell receptor/major histocompatibility complex interactions. European Journal of Immunology. 27: 136-46. PMID 9022010 DOI: 10.1002/Eji.1830270121  0.776
1996 Disis M, Bernhard H, Shiota F, Hand S, Gralow J, Huseby E, Gillis S, Cheever M. Granulocyte-macrophage colony-stimulating factor: an effective adjuvant for protein and peptide-based vaccines Blood. 88: 202-210. DOI: 10.1182/Blood.V88.1.202.Bloodjournal881202  0.362
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