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Adrian T. Keatinge-Clay - Publications

Affiliations: 
Chemistry & Biochemistry University of Texas at Austin, Austin, Texas, U.S.A. 
Area:
Natural Product Biochemistry
Website:
http://www.cm.utexas.edu/adrian_keatinge-clay
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56 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Dickinson MS, Miyazawa T, McCool RS, Keatinge-Clay AT. Priming enzymes from the pikromycin synthase reveal how assembly-line ketosynthases catalyze carbon-carbon chemistry. Structure (London, England : 1993). PMID 35738283 DOI: 10.1016/j.str.2022.05.021  0.739
2021 Hirsch M, Fitzgerald BJ, Keatinge-Clay AT. How -Acyltransferase Assembly-Line Ketosynthases Gatekeep for Processed Polyketide Intermediates. Acs Chemical Biology. 16: 2515-2526. PMID 34590822 DOI: 10.1021/acschembio.1c00598  0.359
2020 Miyazawa T, Hirsch M, Zhang Z, Keatinge-Clay AT. An in vitro platform for engineering and harnessing modular polyketide synthases. Nature Communications. 11: 80. PMID 31900404 DOI: 10.1038/S41467-019-13811-0  0.381
2019 Zhang Z, Cepeda AJ, Robles ML, Hirsch M, Kumru K, Zhou JA, Keatinge-Clay AT. General chemoenzymatic route to two-stereocenter triketides employing assembly line ketoreductases. Chemical Communications (Cambridge, England). PMID 31799975 DOI: 10.1039/C9Cc07966A  0.356
2019 Meinke JL, Simon AJ, Wagner DT, Morrow BR, You S, Ellington AD, Keatinge-Clay AT. Employing 25-Residue Docking Motifs from Modular Polyketide Synthases as Orthogonal Protein Connectors. Acs Synthetic Biology. PMID 31469555 DOI: 10.1021/Acssynbio.9B00047  0.332
2019 Valencia LE, Zhang Z, Cepeda AJ, Keatinge-Clay AT. Seven-enzyme in vitro cascade to (3R)-3-hydroxybutyryl-CoA. Organic & Biomolecular Chemistry. PMID 30652175 DOI: 10.1039/C8Ob02858C  0.371
2018 Meinke JL, Mehaffey MR, Wagner DT, Sun N, Zhang Z, Brodbelt JS, Keatinge-Clay AT. Structural and Functional Studies of a gem-Dimethylating Methyltransferase from a trans-Acyltransferase Assembly Line. Acs Chemical Biology. PMID 30371052 DOI: 10.1021/Acschembio.8B00733  0.448
2018 Liu C, Yuan M, Xu X, Wang L, Keatinge-Clay AT, Deng Z, Lin S, Zheng J. Substrate-bound Structures of a Ketoreductase from Amphotericin Modular Polyketide Synthase. Journal of Structural Biology. PMID 29626512 DOI: 10.1016/J.Jsb.2018.04.001  0.449
2018 Vander Wood DA, Keatinge-Clay AT. The Modules of trans-Acyltransferase Assembly Lines Redefined with a Central Acyl Carrier Protein. Proteins. PMID 29524261 DOI: 10.1002/Prot.25493  0.395
2018 Wagner DT, Zhang Z, Meoded RA, Cepeda AJ, Piel J, Keatinge-Clay AT. Structural and Functional Studies of a Pyran Synthase Domain from a trans-Acyltransferase Assembly Line. Acs Chemical Biology. PMID 29481043 DOI: 10.1021/Acschembio.8B00049  0.456
2017 Wagner DT, Zeng J, Bailey CB, Gay DC, Yuan F, Manion HR, Keatinge-Clay AT. Structural and Functional Trends in Dehydrating Bimodules from trans-Acyltransferase Polyketide Synthases. Structure (London, England : 1993). PMID 28625788 DOI: 10.1016/J.Str.2017.05.011  0.733
2017 Keatinge-Clay AT. The Uncommon Enzymology of Cis-Acyltransferase Assembly Lines. Chemical Reviews. PMID 28394118 DOI: 10.1021/Acs.Chemrev.6B00683  0.33
2016 Zeng J, Wagner DT, Zhang Z, Moretto L, Addison JD, Keatinge-Clay AT. Portability and structure of the four-helix bundle docking domains of trans-acyltransferase modular polyketide synthases. Acs Chemical Biology. PMID 27362945 DOI: 10.1021/Acschembio.6B00345  0.384
2016 Wagner DT, Stevens DC, Mehaffey MR, Manion HR, Taylor RE, Brodbelt JS, Keatinge-Clay AT. α-Methylation follows condensation in the gephyronic acid modular polyketide synthase. Chemical Communications (Cambridge, England). PMID 27346052 DOI: 10.1039/C6Cc04418B  0.689
2016 Stevens DC, Wagner DT, Manion HR, Alexander BK, Keatinge-Clay AT. Methyltransferases excised from trans-AT polyketide synthases operate on N-acetylcysteamine-bound substrates. The Journal of Antibiotics. PMID 27301661 DOI: 10.1038/Ja.2016.66  0.551
2016 Keatinge-Clay AT. The Structural Relationship between Iterative and Modular PKSs. Cell Chemical Biology. 23: 540-2. PMID 27203374 DOI: 10.1016/J.Chembiol.2016.05.005  0.31
2016 Xie X, Garg A, Keatinge-Clay AT, Khosla C, Cane DE. The Epimerase and Reductase Activities of Polyketide Synthase Ketoreductase Domains Utilize the Same Conserved Tyrosine and Serine Residues. Biochemistry. PMID 26863427 DOI: 10.1021/Acs.Biochem.6B00024  0.378
2015 Gay DC, Wagner DT, Meinke JL, Zogzas CE, Gay GR, Keatinge-Clay AT. The LINKS motif zippers trans-acyltransferase polyketide synthase assembly lines into a biosynthetic megacomplex. Journal of Structural Biology. PMID 26724270 DOI: 10.1016/J.Jsb.2015.12.011  0.337
2015 Keatinge-Clay AT. Stereocontrol within polyketide assembly lines. Natural Product Reports. PMID 26584443 DOI: 10.1039/C5Np00092K  0.415
2015 Bailey CB, Pasman ME, Keatinge-Clay AT. Substrate structure-activity relationships guide rational engineering of modular polyketide synthase ketoreductases. Chemical Communications (Cambridge, England). PMID 26568113 DOI: 10.1039/C5Cc07315D  0.744
2015 Fage CD, Meinke JL, Keatinge-Clay AT. Coenzyme A-free activity, crystal structure, and rational engineering of a promiscuous β-ketoacyl thiolase from Ralstonia eutropha. Journal of Molecular Catalysis. B, Enzymatic. 121: 113-121. PMID 26494979 DOI: 10.1016/J.Molcatb.2015.08.007  0.46
2015 Mugnai ML, Shi Y, Keatinge-Clay AT, Elber R. Molecular dynamics studies of modular polyketide synthase ketoreductase stereospecificity. Biochemistry. 54: 2346-59. PMID 25835227 DOI: 10.1021/Bi501401G  0.438
2015 Fage CD, Isiorho EA, Liu Y, Wagner DT, Liu HW, Keatinge-Clay AT. The structure of SpnF, a standalone enzyme that catalyzes [4 + 2] cycloaddition. Nature Chemical Biology. 11: 256-8. PMID 25730549 DOI: 10.1038/Nchembio.1768  0.406
2015 Lee J, Monzingo AF, Keatinge-Clay AT, Harshey RM. Structure of Salmonella FlhE, conserved member of a flagellar type III secretion operon. Journal of Molecular Biology. 427: 1254-62. PMID 25545591 DOI: 10.1016/J.Jmb.2014.11.022  0.372
2014 Fage CD, Brown DB, Boll JM, Keatinge-Clay AT, Trent MS. Crystallographic study of the phosphoethanolamine transferase EptC required for polymyxin resistance and motility in Campylobacter jejuni. Acta Crystallographica. Section D, Biological Crystallography. 70: 2730-9. PMID 25286856 DOI: 10.1107/S1399004714017623  0.434
2014 Gay DC, Spear PJ, Keatinge-Clay AT. A double-hotdog with a new trick: structure and mechanism of the trans-acyltransferase polyketide synthase enoyl-isomerase. Acs Chemical Biology. 9: 2374-81. PMID 25089587 DOI: 10.1021/Cb500459B  0.428
2014 Henderson JC, Fage CD, Cannon JR, Brodbelt JS, Keatinge-Clay AT, Trent MS. Antimicrobial peptide resistance of Vibrio cholerae results from an LPS modification pathway related to nonribosomal peptide synthetases. Acs Chemical Biology. 9: 2382-92. PMID 25068415 DOI: 10.1021/Cb500438X  0.33
2014 Garg A, Xie X, Keatinge-Clay A, Khosla C, Cane DE. Elucidation of the cryptic epimerase activity of redox-inactive ketoreductase domains from modular polyketide synthases by tandem equilibrium isotope exchange. Journal of the American Chemical Society. 136: 10190-3. PMID 25004372 DOI: 10.1021/Ja5056998  0.394
2014 Isiorho EA, Jeon BS, Kim NH, Liu HW, Keatinge-Clay AT. Structural studies of the spinosyn forosaminyltransferase, SpnP. Biochemistry. 53: 4292-301. PMID 24945604 DOI: 10.1021/Bi5003629  0.366
2014 Brantley JN, Bailey CB, Cannon JR, Clark KA, Vanden Bout DA, Brodbelt JS, Keatinge-Clay AT, Bielawski CW. Mechanically modulating the photophysical properties of fluorescent protein biocomposites for ratio- and intensiometric sensors. Angewandte Chemie (International Ed. in English). 53: 5088-92. PMID 24715358 DOI: 10.1002/Anie.201306988  0.68
2014 Piasecki SK, Zheng J, Axelrod AJ, Detelich ME, Keatinge-Clay AT. Structural and functional studies of a trans-acyltransferase polyketide assembly line enzyme that catalyzes stereoselective α- and β-ketoreduction. Proteins. 82: 2067-77. PMID 24634061 DOI: 10.1002/Prot.24561  0.46
2014 Gay DC, Gay G, Axelrod AJ, Jenner M, Kohlhaas C, Kampa A, Oldham NJ, Piel J, Keatinge-Clay AT. A close look at a ketosynthase from a trans-acyltransferase modular polyketide synthase. Structure (London, England : 1993). 22: 444-51. PMID 24508341 DOI: 10.1016/J.Str.2013.12.016  0.477
2014 Hughes AJ, Tibby MR, Wagner DT, Brantley JN, Keatinge-Clay AT. Investigating the reactivities of a polyketide synthase module through fluorescent click chemistry. Chemical Communications (Cambridge, England). 50: 5276-8. PMID 24196586 DOI: 10.1039/C3Cc47513A  0.316
2013 Gay D, You YO, Keatinge-Clay A, Cane DE. Structure and stereospecificity of the dehydratase domain from the terminal module of the rifamycin polyketide synthase. Biochemistry. 52: 8916-28. PMID 24274103 DOI: 10.1021/Bi400988T  0.433
2013 Zheng J, Piasecki SK, Keatinge-Clay AT. Structural studies of an A2-type modular polyketide synthase ketoreductase reveal features controlling α-substituent stereochemistry. Acs Chemical Biology. 8: 1964-71. PMID 23755878 DOI: 10.1021/Cb400161G  0.394
2013 Zheng J, Fage CD, Demeler B, Hoffman DW, Keatinge-Clay AT. The missing linker: a dimerization motif located within polyketide synthase modules. Acs Chemical Biology. 8: 1263-70. PMID 23489133 DOI: 10.1021/Cb400047S  0.398
2013 Zheng J, Keatinge-Clay AT. The status of type i polyketide synthase ketoreductases Medchemcomm. 4: 34-40. DOI: 10.1039/C2Md20191G  0.409
2012 Harper AD, Bailey CB, Edwards AD, Detelich JF, Keatinge-Clay AT. Preparative, in vitro biocatalysis of triketide lactone chiral building blocks. Chembiochem : a European Journal of Chemical Biology. 13: 2200-3. PMID 22951936 DOI: 10.1002/cbic.201200378  0.729
2012 Keatinge-Clay AT. The structures of type I polyketide synthases. Natural Product Reports. 29: 1050-73. PMID 22858605 DOI: 10.1039/C2Np20019H  0.419
2012 Zheng J, Gay DC, Demeler B, White MA, Keatinge-Clay AT. Divergence of multimodular polyketide synthases revealed by a didomain structure. Nature Chemical Biology. 8: 615-21. PMID 22634636 DOI: 10.1038/Nchembio.964  0.434
2012 Isiorho EA, Liu HW, Keatinge-Clay AT. Structural studies of the spinosyn rhamnosyltransferase, SpnG. Biochemistry. 51: 1213-22. PMID 22283226 DOI: 10.1021/Bi201860Q  0.369
2012 Piasecki S, Keatinge-Clay AT. Monitoring biocatalytic transformations mediated by polyketide synthase enzymes in cell lysate via fluorine NMR Synlett. 23: 1840-1842. DOI: 10.1055/S-0032-1316554  0.367
2012 Hughes AJ, Detelich JF, Keatinge-Clay AT. Employing a polyketide synthase module and thioesterase in the semipreparative biocatalysis of diverse triketide pyrones Medchemcomm. 3: 956-959. DOI: 10.1039/C2Md20013A  0.398
2011 Piasecki SK, Taylor CA, Detelich JF, Liu J, Zheng J, Komsoukaniants A, Siegel DR, Keatinge-Clay AT. Employing modular polyketide synthase ketoreductases as biocatalysts in the preparative chemoenzymatic syntheses of diketide chiral building blocks. Chemistry & Biology. 18: 1331-40. PMID 22035802 DOI: 10.1016/J.Chembiol.2011.07.021  0.381
2011 Zheng J, Keatinge-Clay AT. Structural and functional analysis of C2-type ketoreductases from modular polyketide synthases. Journal of Molecular Biology. 410: 105-17. PMID 21570406 DOI: 10.1016/J.Jmb.2011.04.065  0.417
2011 Hughes AJ, Keatinge-Clay A. Enzymatic extender unit generation for in vitro polyketide synthase reactions: structural and functional showcasing of Streptomyces coelicolor MatB. Chemistry & Biology. 18: 165-76. PMID 21338915 DOI: 10.1016/J.Chembiol.2010.12.014  0.499
2010 Valenzano CR, You YO, Garg A, Keatinge-Clay A, Khosla C, Cane DE. Stereospecificity of the dehydratase domain of the erythromycin polyketide synthase. Journal of the American Chemical Society. 132: 14697-9. PMID 20925342 DOI: 10.1021/Ja107344H  0.356
2010 Zheng J, Taylor CA, Piasecki SK, Keatinge-Clay AT. Structural and functional analysis of A-type ketoreductases from the amphotericin modular polyketide synthase. Structure (London, England : 1993). 18: 913-22. PMID 20696392 DOI: 10.1016/J.Str.2010.04.015  0.445
2008 Keatinge-Clay A. Crystal Structure of the Erythromycin Polyketide Synthase Dehydratase Journal of Molecular Biology. 384: 941-953. PMID 18952099 DOI: 10.1016/J.Jmb.2008.09.084  0.446
2008 Castonguay R, Valenzano CR, Chen AY, Keatinge-Clay A, Khosla C, Cane DE. Stereospecificity of ketoreductase domains 1 and 2 of the tylactone modular polyketide synthase. Journal of the American Chemical Society. 130: 11598-9. PMID 18693734 DOI: 10.1021/Ja804453P  0.372
2007 Keatinge-Clay AT. A tylosin ketoreductase reveals how chirality is determined in polyketides. Chemistry & Biology. 14: 898-908. PMID 17719489 DOI: 10.1016/J.Chembiol.2007.07.009  0.381
2006 Keatinge-Clay AT, Stroud RM. The structure of a ketoreductase determines the organization of the beta-carbon processing enzymes of modular polyketide synthases. Structure (London, England : 1993). 14: 737-48. PMID 16564177 DOI: 10.1016/J.Str.2006.01.009  0.576
2004 Keatinge-Clay AT, Maltby DA, Medzihradszky KF, Khosla C, Stroud RM. An antibiotic factory caught in action. Nature Structural & Molecular Biology. 11: 888-93. PMID 15286722 DOI: 10.1038/Nsmb808  0.5
2003 Keatinge-Clay AT, Shelat AA, Savage DF, Tsai SC, Miercke LJ, O'Connell JD, Khosla C, Stroud RM. Catalysis, specificity, and ACP docking site of Streptomyces coelicolor malonyl-CoA:ACP transacylase. Structure (London, England : 1993). 11: 147-54. PMID 12575934 DOI: 10.1016/S0969-2126(03)00004-2  0.679
2002 Pan H, Tsai Sc, Meadows ES, Miercke LJ, Keatinge-Clay AT, O'Connell J, Khosla C, Stroud RM. Crystal structure of the priming beta-ketosynthase from the R1128 polyketide biosynthetic pathway. Structure (London, England : 1993). 10: 1559-68. PMID 12429097 DOI: 10.1016/S0969-2126(02)00889-4  0.55
1998 Jacobsen JR, Keatinge-Clay AT, Cane DE, Khosla C. Precursor-directed biosynthesis of 12-ethyl erythromycin. Bioorganic & Medicinal Chemistry. 6: 1171-7. PMID 9784859 DOI: 10.1016/S0968-0896(98)00081-9  0.386
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