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Tom Maniatis, Phd - Publications

Affiliations: 
Biochemistry and Molecular Biophysics Harvard University, Cambridge, MA, United States 
 Columbia University, New York, NY 
Area:
Regulation of RNA Transcription and Splicing, The Role of Neuroinflammation in ALS, Neurobiology of Disease, Synapses and Circuits, Stem Cell Biology, ALS Disease Mechanisms, Genetic Basis of Neurological Diseases
Website:
http://biochemistry.hs.columbia.edu/faculty/maniatis.htm

238 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Flaherty E, Maniatis T. The role of clustered protocadherins in neurodevelopment and neuropsychiatric diseases. Current Opinion in Genetics & Development. 65: 144-150. PMID 32679536 DOI: 10.1016/j.gde.2020.05.041  0.348
2020 Gerbino V, Kaunga E, Ye J, Canzio D, O'Keeffe S, Rudnick ND, Guarnieri P, Lutz CM, Maniatis T. The Loss of TBK1 Kinase Activity in Motor Neurons or in All Cell Types Differentially Impacts ALS Disease Progression in SOD1 Mice. Neuron. PMID 32220666 DOI: 10.1016/J.Neuron.2020.03.005  0.354
2019 Ye J, Cheung J, Gerbino V, Ahlsén G, Zimanyi C, Hirsh D, Maniatis T. Effects of ALS-associated TANK binding kinase 1 mutations on protein-protein interactions and kinase activity. Proceedings of the National Academy of Sciences of the United States of America. PMID 31748271 DOI: 10.1073/pnas.1915732116  0.317
2019 Canzio D, Maniatis T. The generation of a protocadherin cell-surface recognition code for neural circuit assembly. Current Opinion in Neurobiology. 59: 213-220. PMID 31710891 DOI: 10.1016/J.Conb.2019.10.001  0.358
2019 Canzio D, Nwakeze CL, Horta A, Rajkumar SM, Coffey EL, Duffy EE, Duffié R, Monahan K, O'Keeffe S, Simon MD, Lomvardas S, Maniatis T. Antisense lncRNA Transcription Mediates DNA Demethylation to Drive Stochastic Protocadherin α Promoter Choice. Cell. PMID 30955885 DOI: 10.1016/J.Cell.2019.03.008  0.745
2019 Gelfman S, Dugger SA, Araujo Martins Moreno C, Ren Z, Wolock CJ, Shneider N, Phatnani H, Cirulli ET, Lasseigne BN, Harris T, Maniatis T, Rouleau G, Brown RH, Gitler AD, Myers RM, et al. A new approach for rare variation collapsing on functional protein domains implicates specific genic regions in ALS. Genome Research. PMID 30940688 DOI: 10.1101/Gr.243592.118  0.791
2018 Mountoufaris G, Canzio D, Nwakeze CL, Chen WV, Maniatis T. Writing, Reading, and Translating the Clustered Protocadherin Cell Surface Recognition Code for Neural Circuit Assembly. Annual Review of Cell and Developmental Biology. 34: 471-493. PMID 30296392 DOI: 10.1146/Annurev-Cellbio-100616-060701  0.567
2018 Yuan Y, Xie S, Darnell JC, Darnell AJ, Saito Y, Phatnani H, Murphy EA, Zhang C, Maniatis T, Darnell RB. Cell type-specific CLIP reveals that NOVA regulates cytoskeleton interactions in motoneurons. Genome Biology. 19: 117. PMID 30111345 DOI: 10.1186/S13059-018-1493-2  0.689
2017 Rudnick ND, Griffey CJ, Guarnieri P, Gerbino V, Wang X, Piersaint JA, Tapia JC, Rich MM, Maniatis T. Distinct roles for motor neuron autophagy early and late in the SOD1(G93A) mouse model of ALS. Proceedings of the National Academy of Sciences of the United States of America. PMID 28904095 DOI: 10.1073/pnas.1704294114  0.782
2017 Rizvi AH, Camara PG, Kandror EK, Roberts TJ, Schieren I, Maniatis T, Rabadan R. Single-cell topological RNA-seq analysis reveals insights into cellular differentiation and development. Nature Biotechnology. PMID 28459448 DOI: 10.1038/Nbt.3854  0.361
2017 Mountoufaris G, Chen WV, Hirabayashi Y, O'Keeffe S, Chevee M, Nwakeze CL, Polleux F, Maniatis T. Multicluster Pcdh diversity is required for mouse olfactory neural circuit assembly. Science (New York, N.Y.). 356: 411-414. PMID 28450637 DOI: 10.1126/Science.Aai8801  0.554
2017 Chen WV, Nwakeze CL, Denny CA, O'Keeffe S, Rieger MA, Mountoufaris G, Kirner A, Dougherty JD, Hen R, Wu Q, Maniatis T. Pcdhαc2 is required for axonal tiling and assembly of serotonergic circuitries in mice. Science (New York, N.Y.). 356: 406-411. PMID 28450636 DOI: 10.1126/Science.Aal3231  0.641
2016 Goodman KM, Rubinstein R, Thu CA, Mannepalli S, Bahna F, Ahlsén G, Rittenhouse C, Maniatis T, Honig B, Shapiro L. γ-Protocadherin structural diversity and functional implications. Elife. 5. PMID 27782885 DOI: 10.7554/Elife.20930  0.314
2016 Lomvardas S, Maniatis T. Histone and DNA Modifications as Regulators of Neuronal Development and Function. Cold Spring Harbor Perspectives in Biology. 8. PMID 27371659 DOI: 10.1101/cshperspect.a024208  0.326
2016 He J, Zhou R, Wu Z, Carrasco MA, Kurshan PT, Farley JE, Simon DJ, Wang G, Han B, Hao J, Heller E, Freeman MR, Shen K, Maniatis T, Tessier-Lavigne M, et al. Prevalent presence of periodic actin-spectrin-based membrane skeleton in a broad range of neuronal cell types and animal species. Proceedings of the National Academy of Sciences of the United States of America. PMID 27162329 DOI: 10.1073/Pnas.1605707113  0.395
2016 Goodman KM, Rubinstein R, Thu CA, Bahna F, Mannepalli S, Ahlsén G, Rittenhouse C, Maniatis T, Honig B, Shapiro L. Structural Basis of Diverse Homophilic Recognition by Clustered α- and β-Protocadherins. Neuron. PMID 27161523 DOI: 10.1016/J.Neuron.2016.04.004  0.3
2015 Rubinstein R, Thu CA, Goodman KM, Wolcott HN, Bahna F, Mannepalli S, Ahlsen G, Chevee M, Halim A, Clausen H, Maniatis T, Shapiro L, Honig B. Molecular Logic of Neuronal Self-Recognition through Protocadherin Domain Interactions. Cell. 163: 629-42. PMID 26478182 DOI: 10.1016/J.Cell.2015.09.026  0.327
2015 Guo Y, Xu Q, Canzio D, Shou J, Li J, Gorkin DU, Jung I, Wu H, Zhai Y, Tang Y, Lu Y, Wu Y, Jia Z, Li W, Zhang MQ, ... ... Maniatis T, et al. CRISPR Inversion of CTCF Sites Alters Genome Topology and Enhancer/Promoter Function. Cell. 162: 900-10. PMID 26276636 DOI: 10.1016/J.Cell.2015.07.038  0.782
2015 Ye J, Beetz N, O'Keeffe S, Tapia JC, Macpherson L, Chen WV, Bassel-Duby R, Olson EN, Maniatis T. hnRNP U protein is required for normal pre-mRNA splicing and postnatal heart development and function. Proceedings of the National Academy of Sciences of the United States of America. 112: E3020-9. PMID 26039991 DOI: 10.1073/Pnas.1508461112  0.563
2015 Phatnani H, Maniatis T. Astrocytes in Neurodegenerative Disease. Cold Spring Harbor Perspectives in Biology. 7. PMID 25877220 DOI: 10.1101/cshperspect.a020628  0.639
2015 Cirulli ET, Lasseigne BN, Petrovski S, Sapp PC, Dion PA, Leblond CS, Couthouis J, Lu YF, Wang Q, Krueger BJ, Ren Z, Keebler J, Han Y, Levy SE, Boone BE, ... ... Maniatis T, et al. Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways. Science (New York, N.Y.). 347: 1436-41. PMID 25700176 DOI: 10.1126/Science.Aaa3650  0.757
2014 Zhang Y, Chen K, Sloan SA, Bennett ML, Scholze AR, O'Keeffe S, Phatnani HP, Guarnieri P, Caneda C, Ruderisch N, Deng S, Liddelow SA, Zhang C, Daneman R, Maniatis T, et al. An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 11929-47. PMID 25186741 DOI: 10.1523/Jneurosci.1860-14.2014  0.691
2014 Thu CA, Chen WV, Rubinstein R, Chevee M, Wolcott HN, Felsovalyi KO, Tapia JC, Shapiro L, Honig B, Maniatis T. Single-cell identity generated by combinatorial homophilic interactions between α, β, and γ protocadherins. Cell. 158: 1045-59. PMID 25171406 DOI: 10.1016/J.Cell.2014.07.012  0.576
2014 Nishimura AL, Shum C, Scotter EL, Abdelgany A, Sardone V, Wright J, Lee YB, Chen HJ, Bilican B, Carrasco M, Maniatis T, Chandran S, Rogelj B, Gallo JM, Shaw CE. Allele-specific knockdown of ALS-associated mutant TDP-43 in neural stem cells derived from induced pluripotent stem cells. Plos One. 9: e91269. PMID 24651281 DOI: 10.1371/journal.pone.0091269  0.336
2014 Alami NH, Smith RB, Carrasco MA, Williams LA, Winborn CS, Han SS, Kiskinis E, Winborn B, Freibaum BD, Kanagaraj A, Clare AJ, Badders NM, Bilican B, Chaum E, Chandran S, ... ... Maniatis T, et al. Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations. Neuron. 81: 536-43. PMID 24507191 DOI: 10.1016/J.Neuron.2013.12.018  0.352
2013 Chen WV, Maniatis T. Clustered protocadherins. Development (Cambridge, England). 140: 3297-302. PMID 23900538 DOI: 10.1242/dev.090621  0.498
2013 Bilican B, Serio A, Shaw CE, Maniatis T, Chandran S. Unpicking neurodegeneration in a dish with human pluripotent stem cells: one cell type at a time. Cell Cycle (Georgetown, Tex.). 12: 2339-40. PMID 23856579 DOI: 10.4161/cc.25705  0.356
2013 Chiu IM, Morimoto ET, Goodarzi H, Liao JT, O'Keeffe S, Phatnani HP, Muratet M, Carroll MC, Levy S, Tavazoie S, Myers RM, Maniatis T. A neurodegeneration-specific gene-expression signature of acutely isolated microglia from an amyotrophic lateral sclerosis mouse model. Cell Reports. 4: 385-401. PMID 23850290 DOI: 10.1016/J.Celrep.2013.06.018  0.789
2013 Bilican B, Serio A, Barmada SJ, Nishimura AL, Sullivan GJ, Carrasco M, Phatnani HP, Puddifoot CA, Story D, Fletcher J, Park IH, Friedman BA, Daley GQ, Wyllie DJ, Hardingham GE, ... ... Maniatis T, et al. Comment on "Drug screening for ALS using patient-specific induced pluripotent stem cells". Science Translational Medicine. 5: 188le2. PMID 23740897 DOI: 10.1126/Scitranslmed.3005065  0.659
2013 Larabi A, Devos JM, Ng SL, Nanao MH, Round A, Maniatis T, Panne D. Crystal structure and mechanism of activation of TANK-binding kinase 1. Cell Reports. 3: 734-46. PMID 23453971 DOI: 10.1016/J.Celrep.2013.01.034  0.584
2013 Serio A, Bilican B, Barmada SJ, Ando DM, Zhao C, Siller R, Burr K, Haghi G, Story D, Nishimura AL, Carrasco MA, Phatnani HP, Shum C, Wilmut I, Maniatis T, et al. Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy. Proceedings of the National Academy of Sciences of the United States of America. 110: 4697-702. PMID 23401527 DOI: 10.1073/Pnas.1300398110  0.684
2013 Phatnani HP, Guarnieri P, Friedman BA, Carrasco MA, Muratet M, O'Keeffe S, Nwakeze C, Pauli-Behn F, Newberry KM, Meadows SK, Tapia JC, Myers RM, Maniatis T. Intricate interplay between astrocytes and motor neurons in ALS. Proceedings of the National Academy of Sciences of the United States of America. 110: E756-65. PMID 23388633 DOI: 10.1073/Pnas.1222361110  0.736
2012 Guo Y, Monahan K, Wu H, Gertz J, Varley KE, Li W, Myers RM, Maniatis T, Wu Q. CTCF/cohesin-mediated DNA looping is required for protocadherin α promoter choice. Proceedings of the National Academy of Sciences of the United States of America. 109: 21081-6. PMID 23204437 DOI: 10.1073/Pnas.1219280110  0.805
2012 Yamazaki T, Chen S, Yu Y, Yan B, Haertlein TC, Carrasco MA, Tapia JC, Zhai B, Das R, Lalancette-Hebert M, Sharma A, Chandran S, Sullivan G, Nishimura AL, Shaw CE, ... ... Maniatis T, et al. FUS-SMN protein interactions link the motor neuron diseases ALS and SMA. Cell Reports. 2: 799-806. PMID 23022481 DOI: 10.1016/J.Celrep.2012.08.025  0.514
2012 Li Y, Xiao H, Chiou TT, Jin H, Bonhomme B, Miralles CP, Pinal N, Ali R, Chen WV, Maniatis T, De Blas AL. Molecular and functional interaction between protocadherin-γC5 and GABAA receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 11780-97. PMID 22915120 DOI: 10.1523/Jneurosci.0969-12.2012  0.513
2012 Chen WV, Alvarez FJ, Lefebvre JL, Friedman B, Nwakeze C, Geiman E, Smith C, Thu CA, Tapia JC, Tasic B, Sanes JR, Maniatis T. Functional significance of isoform diversification in the protocadherin gamma gene cluster. Neuron. 75: 402-9. PMID 22884324 DOI: 10.1016/J.Neuron.2012.06.039  0.729
2012 Lefebvre JL, Kostadinov D, Chen WV, Maniatis T, Sanes JR. Protocadherins mediate dendritic self-avoidance in the mammalian nervous system. Nature. 488: 517-21. PMID 22842903 DOI: 10.1038/Nature11305  0.498
2012 Monahan K, Rudnick ND, Kehayova PD, Pauli F, Newberry KM, Myers RM, Maniatis T. Role of CCCTC binding factor (CTCF) and cohesin in the generation of single-cell diversity of protocadherin-α gene expression. Proceedings of the National Academy of Sciences of the United States of America. 109: 9125-30. PMID 22550178 DOI: 10.1073/Pnas.1205074109  0.776
2012 Bilican B, Serio A, Barmada SJ, Nishimura AL, Sullivan GJ, Carrasco M, Phatnani HP, Puddifoot CA, Story D, Fletcher J, Park IH, Friedman BA, Daley GQ, Wyllie DJ, Hardingham GE, ... ... Maniatis T, et al. Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability. Proceedings of the National Academy of Sciences of the United States of America. 109: 5803-8. PMID 22451909 DOI: 10.1073/Pnas.1202922109  0.698
2012 Zhao M, Zhang J, Phatnani H, Scheu S, Maniatis T. Stochastic expression of the interferon-β gene Plos Biology. 10. PMID 22291574 DOI: 10.1371/Journal.Pbio.1001249  0.674
2011 Ng SL, Friedman BA, Schmid S, Gertz J, Myers RM, Tenoever BR, Maniatis T. IκB kinase epsilon (IKK(epsilon)) regulates the balance between type I and type II interferon responses. Proceedings of the National Academy of Sciences of the United States of America. 108: 21170-5. PMID 22171011 DOI: 10.1073/Pnas.1119137109  0.68
2011 Kehayova P, Monahan K, Chen W, Maniatis T. Regulatory elements required for the activation and repression of the protocadherin-á gene cluster Proceedings of the National Academy of Sciences of the United States of America. 108: 17195-17200. PMID 21949399 DOI: 10.1073/Pnas.1114357108  0.787
2011 Friedman BA, Maniatis T. ExpressionPlot: A web-based framework for analysis of RNA-Seq and microarray gene expression data Genome Biology. 12. PMID 21797991 DOI: 10.7490/F1000Research.276.1  0.313
2011 Ye J, Maniatis T. Negative regulation of interferon-β gene expression during acute and persistent virus infections. Plos One. 6: e20681. PMID 21677781 DOI: 10.1371/journal.pone.0020681  0.35
2010 Buchanan SM, Schalm SS, Maniatis T. Proteolytic processing of protocadherin proteins requires endocytosis Proceedings of the National Academy of Sciences of the United States of America. 107: 17774-17779. PMID 20876099 DOI: 10.1073/Pnas.1013105107  0.708
2010 Schalm SS, Ballif BA, Buchanan SM, Phillips GR, Maniatis T. Phosphorylation of protocadherin proteins by the receptor tyrosine kinase Ret Proceedings of the National Academy of Sciences of the United States of America. 107: 13894-13899. PMID 20616001 DOI: 10.1073/Pnas.1007182107  0.705
2009 Chiu IM, Phatnani H, Kuligowski M, Tapia JC, Carrasco MA, Zhang M, Maniatis T, Carroll MC. Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 106: 20960-5. PMID 19933335 DOI: 10.1073/Pnas.0911405106  0.749
2008 Falvo JV, Lin CH, Tsytsykova AV, Hwang PK, Thanos D, Goldfeld AE, Maniatis T. A dimer-specific function of the transcription factor NFATp Proceedings of the National Academy of Sciences of the United States of America. 105: 19637-19642. PMID 19060202 DOI: 10.1073/Pnas.0810648105  0.6
2008 Makeyev EV, Maniatis T. Multilevel regulation of gene expression by microRNAs Science. 319: 1789-1790. PMID 18369137 DOI: 10.1126/science.1152326  0.334
2007 Makeyev EV, Zhang J, Carrasco MA, Maniatis T. The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing. Molecular Cell. 27: 435-48. PMID 17679093 DOI: 10.1016/j.molcel.2007.07.015  0.305
2007 Panne D, Maniatis T, Harrison SC. An atomic model of the interferon-beta enhanceosome. Cell. 129: 1111-23. PMID 17574024 DOI: 10.1016/J.Cell.2007.05.019  0.391
2007 Panne D, McWhirter SM, Maniatis T, Harrison SC. Interferon regulatory factor 3 is regulated by a dual phosphorylation-dependent switch. The Journal of Biological Chemistry. 282: 22816-22. PMID 17526488 DOI: 10.1074/Jbc.M703019200  0.307
2007 Di Giorgio FP, Carrasco MA, Siao MC, Maniatis T, Eggan K. Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model. Nature Neuroscience. 10: 608-14. PMID 17435754 DOI: 10.1038/Nn1885  0.767
2007 Tenoever BR, Ng SL, Chua MA, McWhirter SM, García-Sastre A, Maniatis T. Multiple functions of the IKK-related kinase IKKepsilon in interferon-mediated antiviral immunity. Science (New York, N.Y.). 315: 1274-8. PMID 17332413 DOI: 10.1126/Science.1136567  0.637
2006 Ribich S, Tasic B, Maniatis T. Identification of long-range regulatory elements in the protocadherin-alpha gene cluster. Proceedings of the National Academy of Sciences of the United States of America. 103: 19719-24. PMID 17172445 DOI: 10.1073/Pnas.0609445104  0.795
2006 Maciag K, Altschuler SJ, Slack MD, Krogan NJ, Emili A, Greenblatt JF, Maniatis T, Wu LF. Systems-level analyses identify extensive coupling among gene expression machines. Molecular Systems Biology. 2: 2006.0003. PMID 16738550 DOI: 10.1038/Msb4100045  0.346
2005 Zhou R, Silverman N, Hong M, Liao DS, Chung Y, Chen ZJ, Maniatis T. The role of ubiquitination in Drosophila innate immunity Journal of Biological Chemistry. 280: 34048-34055. PMID 16081424 DOI: 10.1074/Jbc.M506655200  0.432
2005 Takahara T, Tasic B, Maniatis T, Akanuma H, Yanagisawa S. Delay in synthesis of the 3' splice site promotes trans-splicing of the preceding 5' splice site. Molecular Cell. 18: 245-51. PMID 15837427 DOI: 10.1016/J.Molcel.2005.03.018  0.65
2005 Ibrahim EC, Schaal TD, Hertel KJ, Reed R, Maniatis T. Serine/arginine-rich protein-dependent suppression of exon skipping by exonic splicing enhancers. Proceedings of the National Academy of Sciences of the United States of America. 102: 5002-7. PMID 15753297 DOI: 10.1073/Pnas.0500543102  0.55
2004 Panne D, Maniatis T, Harrison SC. Crystal structure of ATF-2/c-Jun and IRF-3 bound to the interferon-β enhancer Embo Journal. 23: 4384-4393. PMID 15510218 DOI: 10.1038/Sj.Emboj.7600453  0.415
2004 McWhirter SM, Fitzgerald KA, Rosains J, Rowe DC, Golenbock DT, Maniatis T. IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts Proceedings of the National Academy of Sciences of the United States of America. 101: 233-238. PMID 14679297 DOI: 10.1073/Pnas.2237236100  0.434
2003 Silverman N, Zhou R, Erlich RL, Hunter M, Bernstein E, Schneider D, Maniatis T. Immune activation of NF-kappaB and JNK requires Drosophila TAK1. The Journal of Biological Chemistry. 278: 48928-48934. PMID 14519762 DOI: 10.1074/Jbc.M304802200  0.321
2003 Stoven S, Silverman N, Junell A, Hedengren-Olcott M, Erturk D, Engstrom Y, Maniatis T, Hultmark D. Caspase-mediated processing of the Drosophila NF-kappaB factor Relish. Proceedings of the National Academy of Sciences of the United States of America. 100: 5991-6. PMID 12732719 DOI: 10.1073/pnas.1035902100  0.374
2003 Fitzgerald KA, McWhirter SM, Faia KL, Rowe DC, Latz E, Golenbock DT, Coyle AJ, Liao SM, Maniatis T. IKKE and TBKI are essential components of the IRF3 signalling pathway Nature Immunology. 4: 491-496. PMID 12692549 DOI: 10.1038/Ni921  0.308
2002 Tasic B, Nabholz CE, Baldwin KK, Kim Y, Rueckert EH, Ribich SA, Cramer P, Wu Q, Axel R, Maniatis T. Promoter choice determines splice site selection in protocadherin alpha and gamma pre-mRNA splicing. Molecular Cell. 10: 21-33. PMID 12150904 DOI: 10.1016/S1097-2765(02)00578-6  0.794
2002 Maniatis T, Tasic B. Alternative pre-mRNA splicing and proteome expansion in metazoans. Nature. 418: 236-43. PMID 12110900 DOI: 10.1038/418236A  0.632
2002 Maniatis T, Reed R. An extensive network of coupling among gene expression machines. Nature. 416: 499-506. PMID 11932736 DOI: 10.1038/416499A  0.528
2001 Lin CH, Hare BJ, Wagner G, Harrison SC, Maniatis T, Fraenkel E. A small domain of CBP/p300 binds diverse proteins: solution structure and functional studies. Molecular Cell. 8: 581-90. PMID 11583620 DOI: 10.1016/S1097-2765(01)00333-1  0.567
2001 Graveley BR, Hertel KJ, Maniatis T. The role of U2AF35 and U2AF65 in enhancer-dependent splicing. Rna (New York, N.Y.). 7: 806-18. PMID 11421359 DOI: 10.1017/S1355838201010317  0.635
2001 Wu Q, Zhang T, Cheng JF, Kim Y, Grimwood J, Schmutz J, Dickson M, Noonan JP, Zhang MQ, Myers RM, Maniatis T. Comparative DNA sequence analysis of mouse and human protocadherin gene clusters. Genome Research. 11: 389-404. PMID 11230163 DOI: 10.1101/Gr.167301  0.795
2000 Agalioti T, Lomvardas S, Parekh B, Yie J, Maniatis T, Thanos D. Ordered recruitment of chromatin modifying and general transcription factors to the IFN-beta promoter. Cell. 103: 667-78. PMID 11106736 DOI: 10.1016/S0092-8674(00)00169-0  0.371
2000 Silverman N, Zhou R, Stöven S, Pandey N, Hultmark D, Maniatis T. A Drosophila IkappaB kinase complex required for Relish cleavage and antibacterial immunity. Genes & Development. 14: 2461-71. PMID 11018014 DOI: 10.1101/Gad.817800  0.431
2000 Falvo JV, Parekh BS, Lin CH, Fraenkel E, Maniatis T. Assembly of a functional beta interferon enhanceosome is dependent on ATF-2-c-jun heterodimer orientation. Molecular and Cellular Biology. 20: 4814-25. PMID 10848607 DOI: 10.1128/Mcb.20.13.4814-4825.2000  0.589
2000 Wu Q, Maniatis T. Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes. Proceedings of the National Academy of Sciences of the United States of America. 97: 3124-9. PMID 10716726 DOI: 10.1073/Pnas.97.7.3124  0.576
2000 Falvo JV, Uglialoro AM, Brinkman BM, Merika M, Parekh BS, Tsai EY, King HC, Morielli AD, Peralta EG, Maniatis T, Thanos D, Goldfeld AE. Stimulus-specific assembly of enhancer complexes on the tumor necrosis factor alpha gene promoter. Molecular and Cellular Biology. 20: 2239-47. PMID 10688670 DOI: 10.1128/Mcb.20.6.2239-2247.2000  0.318
1999 Wu Q, Maniatis T. A striking organization of a large family of human neural cadherin-like cell adhesion genes. Cell. 97: 779-90. PMID 10380929 DOI: 10.1016/S0092-8674(00)80789-8  0.579
1999 Hertel KJ, Maniatis T. Serine-arginine (SR)-rich splicing factors have an exon-independent function in pre-mRNA splicing. Proceedings of the National Academy of Sciences of the United States of America. 96: 2651-5. PMID 10077565 DOI: 10.1073/Pnas.96.6.2651  0.38
1999 Parekh BS, Maniatis T. Virus infection leads to localized hyperacetylation of histones H3 and H4 at the IFN-beta promoter. Molecular Cell. 3: 125-9. PMID 10024886 DOI: 10.1016/S1097-2765(00)80181-1  0.361
1999 Schaal TD, Maniatis T. Selection and characterization of pre-mRNA splicing enhancers: identification of novel SR protein-specific enhancer sequences. Molecular and Cellular Biology. 19: 1705-19. PMID 10022858 DOI: 10.1128/Mcb.19.3.1705  0.378
1999 Graveley BR, Hertel KJ, Maniatis T. SR proteins are 'locators' of the RNA splicing machinery. Current Biology : Cb. 9: R6-7. PMID 9889128 DOI: 10.1016/S0960-9822(99)80032-3  0.545
1999 Ren B, Chee KJ, Kim TH, Maniatis T. PRDI-BF1/Blimp-1 repression is mediated by corepressors of the Groucho family of proteins. Genes & Development. 13: 125-37. PMID 9887105 DOI: 10.1101/Gad.13.1.125  0.716
1999 Schaal TD, Maniatis T. Multiple distinct splicing enhancers in the protein-coding sequences of a constitutively spliced pre-mRNA. Molecular and Cellular Biology. 19: 261-73. PMID 9858550 DOI: 10.1128/Mcb.19.1.261  0.386
1998 Maniatis T, Falvo JV, Kim TH, Kim TK, Lin CH, Parekh BS, Wathelet MG. Structure and function of the interferon-beta enhanceosome. Cold Spring Harbor Symposia On Quantitative Biology. 63: 609-20. PMID 10384326 DOI: 10.1101/SQB.1998.63.609  0.625
1998 Graveley BR, Hertel KJ, Maniatis T. A systematic analysis of the factors that determine the strength of pre-mRNA splicing enhancers. The Embo Journal. 17: 6747-56. PMID 9822617 DOI: 10.1093/Emboj/17.22.6747  0.622
1998 Kim TK, Kim TH, Maniatis T. Efficient recruitment of TFIIB and CBP-RNA polymerase II holoenzyme by an interferon-beta enhanceosome in vitro. Proceedings of the National Academy of Sciences of the United States of America. 95: 12191-6. PMID 9770462 DOI: 10.1073/pnas.95.21.12191  0.599
1998 Graveley BR, Maniatis T. Arginine/serine-rich domains of SR proteins can function as activators of pre-mRNA splicing. Molecular Cell. 1: 765-71. PMID 9660960 DOI: 10.1016/S1097-2765(00)80076-3  0.604
1998 Wathelet MG, Lin CH, Parekh BS, Ronco LV, Howley PM, Maniatis T. Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo. Molecular Cell. 1: 507-18. PMID 9660935 DOI: 10.1016/S1097-2765(00)80051-9  0.601
1998 Hertel KJ, Maniatis T. The function of multisite splicing enhancers. Molecular Cell. 1: 449-55. PMID 9660929 DOI: 10.1016/S1097-2765(00)80045-3  0.361
1998 Ren B, Maniatis T. Regulation of Drosophila Adh promoter switching by an initiator-targeted repression mechanism. The Embo Journal. 17: 1076-86. PMID 9463385 DOI: 10.1093/Emboj/17.4.1076  0.604
1998 Sears C, Olesen J, Rubin D, Finley D, Maniatis T. NF-kappa B p105 processing via the ubiquitin-proteasome pathway. The Journal of Biological Chemistry. 273: 1409-19. PMID 9430676 DOI: 10.1074/Jbc.273.3.1409  0.739
1997 Kim TK, Maniatis T. The mechanism of transcriptional synergy of an in vitro assembled interferon-beta enhanceosome. Molecular Cell. 1: 119-29. PMID 9659909 DOI: 10.1016/S1097-2765(00)80013-1  0.423
1997 Hertel KJ, Lynch KW, Maniatis T. Common themes in the function of transcription and splicing enhancers. Current Opinion in Cell Biology. 9: 350-7. PMID 9159075 DOI: 10.1016/S0955-0674(97)80007-5  0.605
1997 Yang JH, Sklar P, Axel R, Maniatis T. Purification and characterization of a human RNA adenosine deaminase for glutamate receptor B pre-mRNA editing. Proceedings of the National Academy of Sciences of the United States of America. 94: 4354-9. PMID 9113993 DOI: 10.1073/pnas.94.9.4354  0.563
1997 Powell DM, Amaral MC, Wu JY, Maniatis T, Greene WC. HIV Rev-dependent binding of SF2/ASF to the Rev response element: possible role in Rev-mediated inhibition of HIV RNA splicing. Proceedings of the National Academy of Sciences of the United States of America. 94: 973-8. PMID 9023367 DOI: 10.1073/pnas.94.3.973  0.341
1996 Thanos D, Maniatis T. In vitro assembly of enhancer complexes. Methods in Enzymology. 274: 162-73. PMID 8902803 DOI: 10.1016/S0076-6879(96)74015-6  0.373
1996 Hertel KJ, Lynch KW, Hsiao EC, Liu EH, Maniatis T. Structural and functional conservation of the Drosophila doublesex splicing enhancer repeat elements. Rna (New York, N.Y.). 2: 969-81. PMID 8849774  0.521
1996 Kim TK, Maniatis T. Regulation of interferon-gamma-activated STAT1 by the ubiquitin-proteasome pathway. Science (New York, N.Y.). 273: 1717-9. PMID 8781235 DOI: 10.1126/Science.273.5282.1717  0.332
1996 Lynch KW, Maniatis T. Assembly of specific SR protein complexes on distinct regulatory elements of the Drosophila doublesex splicing enhancer. Genes & Development. 10: 2089-101. PMID 8769651 DOI: 10.1101/Gad.10.16.2089  0.583
1995 Falvo JV, Thanos D, Maniatis T. Reversal of intrinsic DNA bends in the IFN beta gene enhancer by transcription factors and the architectural protein HMG I(Y). Cell. 83: 1101-11. PMID 8548798 DOI: 10.1016/0092-8674(95)90137-X  0.394
1995 Thanos D, Maniatis T. Virus induction of human IFN beta gene expression requires the assembly of an enhanceosome. Cell. 83: 1091-100. PMID 8548797 DOI: 10.1016/0092-8674(95)90136-1  0.421
1995 Hedley ML, Amrein H, Maniatis T. An amino acid sequence motif sufficient for subnuclear localization of an arginine/serine-rich splicing factor. Proceedings of the National Academy of Sciences of the United States of America. 92: 11524-8. PMID 8524796 DOI: 10.1073/pnas.92.25.11524  0.667
1995 Yang JH, Sklar P, Axel R, Maniatis T. Editing of glutamate receptor subunit B pre-mRNA in vitro by site-specific deamination of adenosine. Nature. 374: 77-81. PMID 7870177 DOI: 10.1038/374077a0  0.557
1995 Lynch KW, Maniatis T. Synergistic interactions between two distinct elements of a regulated splicing enhancer. Genes & Development. 9: 284-93. PMID 7867927 DOI: 10.1101/Gad.9.3.284  0.596
1995 Thanos D, Maniatis T. Identification of the rel family members required for virus induction of the human beta interferon gene Molecular and Cellular Biology. 15: 152-164. PMID 7799921 DOI: 10.1128/Mcb.15.1.152  0.385
1995 Lazar G, Schaal T, Maniatis T, Goodman HM. Identification of a plant serine-arginine-rich protein similar to the mammalian splicing factor SF2/ASF. Proceedings of the National Academy of Sciences of the United States of America. 92: 7672-6. PMID 7644475 DOI: 10.1073/Pnas.92.17.7672  0.316
1995 Bruzik JP, Maniatis T. Enhancer-dependent interaction between 5' and 3' splice sites in trans. Proceedings of the National Academy of Sciences of the United States of America. 92: 7056-9. PMID 7624368 DOI: 10.1073/Pnas.92.15.7056  0.357
1995 Collins T, Read MA, Neish AS, Whitley MZ, Thanos D, Maniatis T. Transcriptional regulation of endothelial cell adhesion molecules: NF-kappa B and cytokine-inducible enhancers. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 9: 899-909. PMID 7542214 DOI: 10.1096/Fasebj.9.10.7542214  0.409
1995 Axel R, Maniatis T. Harold Weintraub (1945–1995) Cell. 81: 317-318. DOI: 10.1016/0092-8674(95)90382-8  0.481
1994 Tjian R, Maniatis T. Transcriptional activation: A complex puzzle with few easy pieces Cell. 77: 5-8. PMID 8156597 DOI: 10.1016/0092-8674(94)90227-5  0.51
1994 Amrein H, Hedley ML, Maniatis T. The role of specific protein-RNA and protein-protein interactions in positive and negative control of pre-mRNA splicing by Transformer 2. Cell. 76: 735-46. PMID 8124712 DOI: 10.1016/0092-8674(94)90512-6  0.678
1994 Lehming N, Thanos D, Brickman JM, Ma J, Maniatis T, Ptashne M. An HMG-like protein that can switch a transcriptional activator to a repressor. Nature. 371: 175-9. PMID 8072548 DOI: 10.1038/371175A0  0.641
1994 Du W, Maniatis T. The high mobility group protein HMG I(Y) can stimulate or inhibit DNA binding of distinct transcription factor ATF-2 isoforms Proceedings of the National Academy of Sciences of the United States of America. 91: 11318-11322. PMID 7972056 DOI: 10.1073/Pnas.91.24.11318  0.377
1993 Du W, Thanos D, Maniatis T. Mechanisms of transcriptional synergism between distinct virus-inducible enhancer elements Cell. 74: 887-898. PMID 8374955 DOI: 10.1016/0092-8674(93)90468-6  0.375
1993 Tian M, Maniatis T. A splicing enhancer complex controls alternative splicing of doublesex pre-mRNA Cell. 74: 105-114. PMID 8334698 DOI: 10.1016/0092-8674(93)90298-5  0.366
1993 Wu JY, Maniatis T. Specific interactions between proteins implicated in splice site selection and regulated alternative splicing. Cell. 75: 1061-70. PMID 8261509 DOI: 10.1016/0092-8674(93)90316-I  0.456
1993 Abel T, Michelson AM, Maniatis T. A Drosophila GATA family member that binds to Adh regulatory sequences is expressed in the developing fat body. Development (Cambridge, England). 119: 623-33. PMID 8187633  0.642
1993 Winick J, Abel T, Leonard MW, Michelson AM, Chardon-Loriaux I, Holmgren RA, Maniatis T, Engel JD. A GATA family transcription factor is expressed along the embryonic dorsoventral axis in Drosophila melanogaster. Development (Cambridge, England). 119: 1055-65. PMID 7916677  0.675
1992 Maniatis T, Weintraub H. Gene expression and differentiation Current Opinion in Genetics and Development. 2: 197-198. PMID 1638112 DOI: 10.1016/S0959-437X(05)80273-4  0.337
1992 Palombella VJ, Maniatis T. Inducible processing of interferon regulatory factor-2 Molecular and Cellular Biology. 12: 3325-3336. PMID 1630448 DOI: 10.1128/Mcb.12.8.3325  0.411
1992 Keller AD, Maniatis T. Only two of the five zinc fingers of the eukaryotic transcriptional repressor PRDI-BF1 are required for sequence-specific DNA binding Molecular and Cellular Biology. 12: 1940-1949. PMID 1569931 DOI: 10.1128/Mcb.12.5.1940  0.375
1992 Tian M, Maniatis T. Positive control of pre-mRNA splicing in vitro Science. 256: 237-240. PMID 1566072 DOI: 10.1126/Science.1566072  0.408
1992 Falb D, Maniatis T. A conserved regulatory unit implicated in tissue-specific gene expression in Drosophila and man Genes and Development. 6: 454-465. PMID 1547943 DOI: 10.1101/Gad.6.3.454  0.382
1992 Du W, Maniatis T. An ATF/CREB binding site protein is required for virus induction of the human interferon β gene Proceedings of the National Academy of Sciences of the United States of America. 89: 2150-2154. PMID 1532252 DOI: 10.1073/Pnas.89.6.2150  0.428
1992 Abel T, Bhatt R, Maniatis T. A Drosophila CREB/ATF transcriptional activator binds to both fat body- and liver-specific regulatory elements. Genes & Development. 6: 466-80. PMID 1532159 DOI: 10.1101/Gad.6.3.466  0.579
1992 Fu XD, Maniatis T. The 35-kDa mammalian splicing factor SC35 mediates specific interactions between U1 and U2 small nuclear ribonucleoprotein particles at the 3' splice site Proceedings of the National Academy of Sciences of the United States of America. 89: 1725-1729. PMID 1531875 DOI: 10.1073/Pnas.89.5.1725  0.508
1992 Falb D, Maniatis T. Drosophila transcriptional repressor protein that binds specifically to negative control elements in fat body enhancers Molecular and Cellular Biology. 12: 4093-4103. PMID 1508206 DOI: 10.1128/Mcb.12.9.4093  0.368
1992 Bruzik JP, Maniatis T. Spliced leader RNAs from lower eukaryotes are trans-spliced in mammalian cells Nature. 360: 692-695. PMID 1465136 DOI: 10.1038/360692a0  0.362
1992 Fu XD, Mayeda A, Maniatis T, Krainer AR. General splicing factors SF2 and SC35 have equivalent activities in vitro, and both affect alternative 5' and 3' splice site selection. Proceedings of the National Academy of Sciences of the United States of America. 89: 11224-8. PMID 1454802 DOI: 10.1073/Pnas.89.23.11224  0.739
1992 Wigler M, Sweet R, Sim GK, Wold B, Pellicer A, Lacy E, Maniatis T, Silverstein S, Axel R. Transformation of mammalian cells with genes from prokaryotes and eukaryotes. 1979. Biotechnology (Reading, Mass.). 24: 444-52. PMID 1422052  0.529
1992 Fu XD, Maniatis T. Isolation of a complementary DNA that encodes the mammalian splicing factor SC35 Science. 256: 535-538. PMID 1373910 DOI: 10.1126/Science.1373910  0.572
1992 Thanos D, Maniatis T. The High Mobility Group protein HMG I(Y) is required for NF-κB-dependent virus induction of the human IFN-β gene Cell. 71: 777-789. PMID 1330326 DOI: 10.1016/0092-8674(92)90554-P  0.389
1992 Maniatis T, Whittemore L, Du W, Fan C, Keller AD, Palombella VJ, Thanos DN. 44 Positive and Negative Control of Human Interferon-β Gene Expression Cold Spring Harbor Monograph Archive. 1193-1220. DOI: 10.1101/087969425.22B.1193  0.381
1991 Goldfeld AE, Doyle C, Maniatis T. Human tumor necrosis factor alpha gene regulation by virus and lipopolysaccharide. Proceedings of the National Academy of Sciences of the United States of America. 87: 9769-73. PMID 2263628 DOI: 10.1073/Pnas.87.24.9769  0.352
1991 Corbin V, Michelson AM, Abmayr SM, Neel V, Alcamo E, Maniatis T, Young MW. A role for the Drosophila neurogenic genes in mesoderm differentiation. Cell. 67: 311-23. PMID 1913825 DOI: 10.1016/0092-8674(91)90183-Y  0.796
1991 Keller AD, Maniatis T. Selection of sequences recognized by a DNA binding protein using a preparative southwestern blot. Nucleic Acids Research. 19: 4675-80. PMID 1891359 DOI: 10.1093/NAR/19.17.4675  0.351
1991 Keller AD, Maniatis T. Identification and characterization of a novel repressor of beta-interferon gene expression. Genes & Development. 5: 868-79. PMID 1851123 DOI: 10.1101/GAD.5.5.868  0.319
1991 Fu XD, Katz RA, Skalka AM, Maniatis T. The role of branchpoint and 3'-exon sequences in the control of balanced splicing of avian retrovirus RNA. Genes & Development. 5: 211-20. PMID 1847346 DOI: 10.1101/Gad.5.2.211  0.522
1991 Spector DL, Fu XD, Maniatis T. Associations between distinct pre-mRNA splicing components and the cell nucleus Embo Journal. 10: 3467-3481. PMID 1833187 DOI: 10.1002/J.1460-2075.1991.Tb04911.X  0.433
1991 Baron MH, Maniatis T. Regulated expression of human alpha- and beta-globin genes in transient heterokaryons. Molecular and Cellular Biology. 11: 1239-47. PMID 1705003 DOI: 10.1128/MCB.11.3.1239  0.426
1991 Hedley ML, Maniatis T. Sex-specific splicing and polyadenylation of dsx pre-mRNA requires a sequence that binds specifically to tra-2 protein in vitro. Cell. 65: 579-86. PMID 1674449 DOI: 10.1016/0092-8674(91)90090-L  0.375
1990 Michelson AM, Abmayr SM, Bate M, Arias AM, Maniatis T. Expression of a MyoD family member prefigures muscle pattern in Drosophila embryos. Genes & Development. 4: 2086-97. PMID 2176634 DOI: 10.1101/Gad.4.12A.2086  0.574
1990 Whittemore LA, Maniatis T. Postinduction repression of the beta-interferon gene is mediated through two positive regulatory domains. Proceedings of the National Academy of Sciences of the United States of America. 87: 7799-803. PMID 2172963 DOI: 10.1073/PNAS.87.20.7799  0.383
1990 Whittemore LA, Maniatis T. Postinduction turnoff of beta-interferon gene expression. Molecular and Cellular Biology. 10: 1329-37. PMID 2157136 DOI: 10.1128/MCB.10.4.1329  0.374
1990 Fu XD, Maniatis T. Factor required for mammalian spliceosome assembly is localized to discrete regions in the nucleus. Nature. 343: 437-41. PMID 2137203 DOI: 10.1038/343437A0  0.467
1990 Amrein H, Maniatis T, Nöthiger R. Alternatively spliced transcripts of the sex-determining gene tra-2 of Drosophila encode functional proteins of different size. The Embo Journal. 9: 3619-29. PMID 2120049 DOI: 10.1002/J.1460-2075.1990.Tb07573.X  0.787
1989 Goto T, Macdonald P, Maniatis T. Early and late periodic patterns of even skipped expression are controlled by distinct regulatory elements that respond to different spatial cues. Cell. 57: 413-22. PMID 2720776 DOI: 10.1016/0092-8674(89)90916-1  0.342
1989 Abel T, Maniatis T. Gene regulation. Action of leucine zippers. Nature. 341: 24-5. PMID 2671752 DOI: 10.1038/341024a0  0.518
1989 Goldfeld AE, Maniatis T. Coordinate viral induction of tumor necrosis factor alpha and interferon beta in human B cells and monocytes. Proceedings of the National Academy of Sciences of the United States of America. 86: 1490-4. PMID 2537976 DOI: 10.1073/Pnas.86.5.1490  0.376
1989 Munro S, Maniatis T. Expression cloning of the murine interferon gamma receptor cDNA. Proceedings of the National Academy of Sciences of the United States of America. 86: 9248-52. PMID 2531896 DOI: 10.1073/pnas.86.23.9248  0.324
1989 Lenardo MJ, Fan CM, Maniatis T, Baltimore D. The involvement of NF-kappa B in beta-interferon gene regulation reveals its role as widely inducible mediator of signal transduction. Cell. 57: 287-94. PMID 2495183 DOI: 10.1016/0092-8674(89)90966-5  0.532
1989 Corbin V, Maniatis T. Role of transcriptional interference in the Drosophila melanogaster Adh promoter switch. Nature. 337: 279-82. PMID 2492088 DOI: 10.1038/337279A0  0.32
1989 Fan CM, Maniatis T. Two different virus-inducible elements are required for human beta-interferon gene regulation. The Embo Journal. 8: 101-110. DOI: 10.1002/j.1460-2075.1989.tb03353.x  0.367
1988 Goodbourn S, Maniatis T. Overlapping positive and negative regulatory domains of the human beta-interferon gene. Proceedings of the National Academy of Sciences of the United States of America. 85: 1447-51. PMID 3422743 DOI: 10.1073/PNAS.85.5.1447  0.437
1988 Keller AD, Maniatis T. Identification of an inducible factor that binds to a positive regulatory element of the human beta-interferon gene. Proceedings of the National Academy of Sciences of the United States of America. 85: 3309-13. PMID 3368441 DOI: 10.1073/PNAS.85.10.3309  0.448
1988 Fischer JA, Maniatis T. Drosophila Adh: A promoter element expands the tissue specificity of an enhancer Cell. 53: 451-461. PMID 3365768 DOI: 10.1016/0092-8674(88)90165-1  0.315
1988 Zinn K, Keller A, Whittemore LA, Maniatis T. 2-Aminopurine selectively inhibits the induction of beta-interferon, c-fos, and c-myc gene expression. Science (New York, N.Y.). 240: 210-3. PMID 3281258 DOI: 10.1126/Science.3281258  0.575
1988 Fischer JA, Giniger E, Maniatis T, Ptashne M. GAL4 activates transcription in Drosophila. Nature. 332: 853-6. PMID 3128741 DOI: 10.1038/332853A0  0.759
1988 Reed R, Maniatis T. The role of the mammalian branchpoint sequence in pre-mRNA splicing. Genes & Development. 2: 1268-76. PMID 3060403 DOI: 10.1101/Gad.2.10.1268  0.465
1988 Abmayr SM, Reed R, Maniatis T. Identification of a functional mammalian spliceosome containing unspliced pre-mRNA. Proceedings of the National Academy of Sciences of the United States of America. 85: 7216-20. PMID 2971971 DOI: 10.1073/Pnas.85.19.7216  0.482
1988 Reed R, Griffith J, Maniatis T. Purification and visualization of native spliceosomes. Cell. 53: 949-61. PMID 2968159 DOI: 10.1016/S0092-8674(88)90489-8  0.449
1987 Myers RM, Maniatis T, Lerman LS. Detection and localization of single base changes by denaturing gradient gel electrophoresis. Methods in Enzymology. 155: 501-27. PMID 3431470 DOI: 10.1016/0076-6879(87)55033-9  0.711
1987 Maniatis T, Goodbourn S, Fischer JA. Regulation of inducible and tissue-specific gene expression Science. 236: 1237-1245. PMID 3296191 DOI: 10.1126/Science.3296191  0.445
1987 Maniatis T, Reed R. The role of small nuclear ribonucleoprotein particles in pre-mRNA splicing. Nature. 325: 673-8. PMID 2950324 DOI: 10.1038/325673A0  0.509
1987 Atweh GF, Wong C, Reed R, Antonarakis SE, Zhu D, Ghosh PK, Maniatis T, Forget BG, Kazazian HH. A new mutation in IVS-1 of the human beta globin gene causing beta thalassemia due to abnormal splicing. Blood. 70: 147-51. PMID 2439149  0.512
1986 Myers RM, Larin Z, Maniatis T. Detection of single base substitutions by ribonuclease cleavage at mismatches in RNA:DNA duplexes. Science (New York, N.Y.). 230: 1242-6. PMID 4071043 DOI: 10.1126/Science.4071043  0.531
1986 Enoch T, Zinn K, Maniatis T. Activation of the human beta-interferon gene requires an interferon-inducible factor. Molecular and Cellular Biology. 6: 801-10. PMID 3773893  0.521
1986 Baron MH, Maniatis T. Rapid reprogramming of globin gene expression in transient heterokaryons. Cell. 46: 591-602. PMID 3731277 DOI: 10.1016/0092-8674(86)90885-8  0.416
1986 Zinn K, Maniatis T. Detection of factors that interact with the human beta-interferon regulatory region in vivo by DNAase I footprinting. Cell. 45: 611-8. PMID 3708689 DOI: 10.1016/0092-8674(86)90293-X  0.586
1986 Goodbourn S, Burstein H, Maniatis T. The human beta-interferon gene enhancer is under negative control. Cell. 45: 601-10. PMID 3708688 DOI: 10.1016/0092-8674(86)90292-8  0.399
1986 Myers RM, Tilly K, Maniatis T. Fine structure genetic analysis of a beta-globin promoter. Science (New York, N.Y.). 232: 613-8. PMID 3457470 DOI: 10.1126/Science.3457470  0.591
1986 Reed R, Maniatis T. A role for exon sequences and splice-site proximity in splice-site selection. Cell. 46: 681-90. PMID 2427200 DOI: 10.1016/0092-8674(86)90343-0  0.518
1985 Myers RM, Fischer SG, Lerman LS, Maniatis T. Nearly all single base substitutions in DNA fragments joined to a GC-clamp can be detected by denaturing gradient gel electrophoresis. Nucleic Acids Research. 13: 3131-45. PMID 4000972 DOI: 10.1093/Nar/13.9.3131  0.722
1985 Goodbourn S, Zinn K, Maniatis T. Human beta-interferon gene expression is regulated by an inducible enhancer element. Cell. 41: 509-20. PMID 3986910 DOI: 10.1016/S0092-8674(85)80024-6  0.597
1985 Myers RM, Lumelsky N, Lerman LS, Maniatis T. Detection of single base substitutions in total genomic DNA. Nature. 313: 495-8. PMID 3969155 DOI: 10.1038/313495a0  0.722
1985 Reed R, Maniatis T. Intron sequences involved in lariat formation during pre-mRNA splicing. Cell. 41: 95-105. PMID 3888410 DOI: 10.1016/0092-8674(85)90064-9  0.541
1985 Charnay P, Mellon P, Maniatis T. Linker scanning mutagenesis of the 5'-flanking region of the mouse beta-major-globin gene: sequence requirements for transcription in erythroid and nonerythroid cells. Molecular and Cellular Biology. 5: 1498-511. PMID 3861935 DOI: 10.1128/Mcb.5.6.1498  0.662
1985 Posakony JW, Fischer JA, Maniatis T. Identification of DNA sequences required for the regulation of Drosophila alcohol dehydrogenase gene expression. Cold Spring Harbor Symposia On Quantitative Biology. 50: 515-20. PMID 3007005 DOI: 10.1101/Sqb.1985.050.01.063  0.65
1985 Fischer JA, Maniatis T. Structure and transcription of the Drosophila mulleri alcohol dehydrogenase genes Nucleic Acids Research. 13: 6899-6917. PMID 2997730 DOI: 10.1093/Nar/13.19.6899  0.358
1985 Krainer AR, Maniatis T. Multiple factors including the small nuclear ribonucleoproteins U1 and U2 are necessary for pre-mRNA splicing in vitro. Cell. 42: 725-36. PMID 2996774 DOI: 10.1016/0092-8674(85)90269-7  0.662
1985 Myers RM, Lerman LS, Maniatis T. A general method for saturation mutagenesis of cloned DNA fragments. Science (New York, N.Y.). 229: 242-7. PMID 2990046 DOI: 10.1126/Science.2990046  0.716
1985 Myers RM, Fischer SG, Maniatis T, Lerman LS. Modification of the melting properties of duplex DNA by attachment of a GC-rich DNA sequence as determined by denaturing gradient gel electrophoresis. Nucleic Acids Research. 13: 3111-29. PMID 2987873 DOI: 10.1093/Nar/13.9.3111  0.725
1985 Treisman R, Maniatis T. Simian virus 40 enhancer increases number of RNA polymerase II molecules on linked DNA. Nature. 315: 73-5. PMID 2986013 DOI: 10.1038/315072A0  0.41
1985 Zuber P, Losick R, Struhl K, Chen W, Hill DE, Hope IA, Oettinger MA, Savakis C, Ashburner M, Posakony JW, Fischer JA, Maniatis T, Wensink PC, Shepherd B, Garabedian MJ, et al. Control of gene expression Cold Spring Harbor Symposia On Quantitative Biology. 50: 483-563. DOI: 10.1016/B978-0-12-455620-1.50012-6  0.321
1984 Krainer AR, Maniatis T, Ruskin B, Green MR. Normal and mutant human beta-globin pre-mRNAs are faithfully and efficiently spliced in vitro. Cell. 36: 993-1005. PMID 6323033 DOI: 10.1016/0092-8674(84)90049-7  0.692
1984 DiMaio D, Corbin V, Sibley E, Maniatis T. High-level expression of a cloned HLA heavy chain gene introduced into mouse cells on a bovine papillomavirus vector. Molecular and Cellular Biology. 4: 340-50. PMID 6321959 DOI: 10.1128/MCB.4.2.340  0.598
1984 Charnay P, Treisman R, Mellon P, Chao M, Axel R, Maniatis T. Differences in human alpha- and beta-globin gene expression in mouse erythroleukemia cells: the role of intragenic sequences. Cell. 38: 251-63. PMID 6205764 DOI: 10.1016/0092-8674(84)90547-6  0.728
1984 Treisman R, Green MR, Maniatis T. cis and trans activation of globin gene transcription in transient assays. Proceedings of the National Academy of Sciences of the United States of America. 80: 7428-32. PMID 6200874 DOI: 10.1073/Pnas.80.24.7428  0.431
1984 Charnay P, Treisman R, Mellon P, Chao M, Axel R, Maniatis T. Human alpha- and beta-globin gene transcription in mouse erythroleukaemia cells. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 307: 261-70. PMID 6151696 DOI: 10.1098/Rstb.1984.0126  0.728
1984 Melton DA, Krieg PA, Rebagliati MR, Maniatis T, Zinn K, Green MR. Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter. Nucleic Acids Research. 12: 7035-56. PMID 6091052 DOI: 10.1093/Nar/12.18.7035  0.524
1984 Ruskin B, Krainer AR, Maniatis T, Green MR. Excision of an intact intron as a novel lariat structure during pre-mRNA splicing in vitro. Cell. 38: 317-31. PMID 6088074 DOI: 10.1016/0092-8674(84)90553-1  0.676
1983 Mellon P, Charnay P, Chao M, Axel R, Maniatis T. Regulated expression of cloned globin genes introduced into mouse erythroleukemia cells. Progress in Clinical and Biological Research. 134: 3-12. PMID 6582520  0.696
1983 Charnay P, Maniatis T. Transcriptional regulation of globin gene expression in the human erythroid cell line K562. Science (New York, N.Y.). 220: 1281-3. PMID 6574602 DOI: 10.1126/Science.6574602  0.608
1983 Chao MV, Mellon P, Charnay P, Maniatis T, Axel R. The regulated expression of beta-globin genes introduced into mouse erythroleukemia cells. Cell. 32: 483-93. PMID 6572107 DOI: 10.1016/0092-8674(83)90468-3  0.74
1983 Green MR, Maniatis T, Melton DA. Human beta-globin pre-mRNA synthesized in vitro is accurately spliced in Xenopus oocyte nuclei. Cell. 32: 681-94. PMID 6550524 DOI: 10.1016/0092-8674(83)90054-5  0.38
1983 Green MR, Treisman R, Maniatis T. Transcriptional activation of cloned human beta-globin genes by viral immediate-early gene products. Cell. 35: 137-48. PMID 6313220 DOI: 10.1016/0092-8674(83)90216-7  0.453
1983 Zinn K, DiMaio D, Maniatis T. Identification of two distinct regulatory regions adjacent to the human beta-interferon gene. Cell. 34: 865-79. PMID 6313211 DOI: 10.1016/0092-8674(83)90544-5  0.723
1983 Goldberg DA, Posakony JW, Maniatis T. Correct developmental expression of a cloned alcohol dehydrogenase gene transduced into the Drosophila germ line. Cell. 34: 59-73. PMID 6309412 DOI: 10.1016/0092-8674(83)90136-8  0.656
1983 Treisman R, Orkin SH, Maniatis T. Specific transcription and RNA splicing defects in five cloned β-thalassaemia genes Nature. 302: 591-596. PMID 6188062 DOI: 10.1038/302591A0  0.408
1983 Chao MV, Mellon P, Charnay P, Maniatis T, Axel R. Introduction and expression of beta-globin genes in murine erythroleukemic cells. Gene Amplification and Analysis. 3: 215-31. PMID 6101028  0.683
1983 Little PF, Treisman R, Bierut L, Seed B, Maniatis T. Plasmid vectors for the rapid isolation and transcriptional analysis of human beta-globin gene alleles. Molecular Biology & Medicine. 1: 473-88. PMID 6094959  0.589
1982 Treisman R, Proudfoot NJ, Shander M, Maniatis T. A single-base change at a splice site in a beta 0-thalassemic gene causes abnormal RNA splicing. Cell. 29: 903-11. PMID 7151176 DOI: 10.1016/0092-8674(82)90452-4  0.605
1982 Zinn K, Mellon P, Ptashne M, Maniatis T. Regulated expression of an extrachromosomal human beta-interferon gene in mouse cells. Proceedings of the National Academy of Sciences of the United States of America. 79: 4897-901. PMID 6956899 DOI: 10.1073/Pnas.79.16.4897  0.693
1982 Proudfoot NJ, Gil A, Maniatis T. The structure of the human zeta-globin gene and a closely linked, nearly identical pseudogene. Cell. 31: 553-63. PMID 6297773 DOI: 10.1016/0092-8674(82)90311-7  0.606
1982 DiMaio D, Treisman R, Maniatis T. Bovine papillomavirus vector that propagates as a plasmid in both mouse and bacterial cells. Proceedings of the National Academy of Sciences of the United States of America. 79: 4030-4. PMID 6287462 DOI: 10.1073/Pnas.79.13.4030  0.629
1981 Shen CK, Maniatis T. Tissue-specific DNA methylation in a cluster of rabbit beta-like globin genes. Proceedings of the National Academy of Sciences of the United States of America. 77: 6634-8. PMID 6935674 DOI: 10.1073/PNAS.77.11.6634  0.385
1981 Maniatis T, Fritsch EF, Lauer J, Lawn RM. The molecular genetics of human hemoglobins. Annual Review of Genetics. 14: 145-78. PMID 6452087 DOI: 10.1146/ANNUREV.GE.14.120180.001045  0.384
1981 Mellon P, Parker V, Gluzman Y, Maniatis T. Identification of DNA sequences required for transcription of the human α1-globin gene in a new SV40 host-vector system Cell. 27: 279-288. PMID 6277501 DOI: 10.1016/0092-8674(81)90411-6  0.41
1981 Fritsch EF, Shen CK, Lawn RM, Maniatis T. The organization of repetitive sequences in mammalian globin gene clusters. Cold Spring Harbor Symposia On Quantitative Biology. 761-5. PMID 6167396 DOI: 10.1101/SQB.1981.045.01.095  0.322
1980 Lacy E, Maniatis T. The nucleotide sequence of a rabbit beta-globin pseudogene. Cell. 21: 545-53. PMID 7407926 DOI: 10.1016/0092-8674(80)90492-4  0.344
1980 Proudfoot NJ, Maniatis T. The structure of a human alpha-globin pseudogene and its relationship to alpha-globin gene duplication. Cell. 21: 537-44. PMID 7407925 DOI: 10.1016/0092-8674(80)90491-2  0.528
1980 Efstratiadis A, Posakony JW, Maniatis T, Lawn RM, O'Connell C, Spritz RA, DeRiel JK, Forget BG, Weissman SM, Slightom JL, Blechl AE, Smithies O, Baralle FE, Shoulders CC, Proudfoot NJ. The structure and evolution of the human beta-globin gene family. Cell. 21: 653-68. PMID 6985477 DOI: 10.1016/0092-8674(80)90429-8  0.745
1980 Lauer J, Shen CKJ, Maniatis T. The chromosomal arrangement of human α-like globin genes: Sequence homology and α-globin gene deletions Cell. 20: 119-130. PMID 6446404 DOI: 10.1016/0092-8674(80)90240-8  0.364
1980 Lawn RM, Efstratiadis A, O'Connell C, Maniatis T. The nucleotide sequence of the human beta-globin gene. Cell. 21: 647-51. PMID 6254664 DOI: 10.1016/0092-8674(80)90428-6  0.382
1980 Shen CK, Maniatis T. The organization of repetitive sequences in a cluster of rabbit beta-like globin genes. Cell. 19: 379-91. PMID 6244107 DOI: 10.1016/0092-8674(80)90512-7  0.388
1980 Proudfoot NJ, Shander MH, Manley JL, Gefter ML, Maniatis T. Structure and in vitro transcription of human globin genes. Science (New York, N.Y.). 209: 1329-36. PMID 6158093 DOI: 10.1126/Science.6158093  0.619
1980 Fritsch EF, Lawn RM, Maniatis T. Molecular cloning and characterization of the human β-like globin gene cluster Cell. 19: 959-972. PMID 6155216 DOI: 10.1016/0092-8674(80)90087-2  0.367
1979 Sim GK, Kafatos FC, Jones CW, Koehler MD, Efstratiadis A, Maniatis T. Use of a cDNA library for studies on evolution and developmental expression of the chorion multigene families. Cell. 18: 1303-16. PMID 519770 DOI: 10.1016/0092-8674(79)90241-1  0.337
1979 Hardison RC, Butler ET, Lacy E, Maniatis T, Rosenthal N, Efstratiadis A. The structure and transcription of four linked rabbit beta-like globin genes. Cell. 18: 1285-97. PMID 519769 DOI: 10.1016/0092-8674(79)90239-3  0.583
1979 Lacy E, Hardison RC, Quon D, Maniatis T. The linkage arrangement of four rabbit beta-like globin genes. Cell. 18: 1273-83. PMID 519768 DOI: 10.1016/0092-8674(79)90238-1  0.546
1979 Fritsch EF, Lawn RM, Maniatis T. Characterisation of deletions which affect the expression of fetal globin genes in man Nature. 279: 598-603. PMID 450109 DOI: 10.1038/279598a0  0.378
1979 Wold B, Wigler M, Lacy E, Maniatis T, Silverstein S, Axel R. Introduction and expression of a rabbit beta-globin gene in mouse fibroblasts. Proceedings of the National Academy of Sciences of the United States of America. 76: 5684-8. PMID 293672 DOI: 10.1073/pnas.76.11.5684  0.648
1979 Wigler M, Sweet R, Sim GK, Wold B, Pellicer A, Lacy E, Maniatis T, Silverstein S, Axel R. Transformation of mammalian cells with genes from procaryotes and eucaryotes. Cell. 16: 777-85. PMID 222468 DOI: 10.1016/0092-8674(79)90093-X  0.594
1978 Maniatis T, Hardison RC, Lacy E, Lauer J, O'Connell C, Quon D, Sim GK, Efstratiadis A. The isolation of structural genes from libraries of eucaryotic DNA. Cell. 15: 687-701. PMID 719759 DOI: 10.1016/0092-8674(78)90036-3  0.577
1978 Sim GK, Efstratiadis A, Jones CW, Kafatos FC, Koehler M, Kronenberg HM, Maniatis T, Regier JC, Roberts BF, Rosenthal N. Studies on the structure of genes expressed during development. Cold Spring Harbor Symposia On Quantitative Biology. 42: 933-45. PMID 277327 DOI: 10.1101/Sqb.1978.042.01.095  0.324
1978 Lawn RM, Fritsch EF, Parker RC, Blake G, Maniatis T. The isolation and characterization of linked δ- and β-globin genes from a cloned library of human DNA Cell. 15: 1157-1174. DOI: 10.1016/0092-8674(78)90043-0  0.359
1977 Efstratiadis A, Kafatos FC, Maniatis T. The primary structure of rabbit beta-globin mRNA as determined from cloned DNA. Cell. 10: 571-85. PMID 558827 DOI: 10.1016/0092-8674(77)90090-3  0.394
1976 Maniatis T, Ptashne M. A DNA operator-repressor system. Scientific American. 234: 64-6, 71-6. PMID 1251177 DOI: 10.1038/Scientificamerican0176-64  0.511
1976 Maniatis T, Kee SG, Efstratiadis A, Kafatos FC. Amplification and characterization of a beta-globin gene synthesized in vitro. Cell. 8: 163-82. PMID 61066 DOI: 10.1016/0092-8674(76)90001-5  0.378
1976 Efstratiadis A, Kafatos FC, Maxam AM, Maniatis T. Enzymatic in vitro synthesis of globin genes. Cell. 7: 279-88. PMID 60178 DOI: 10.1016/0092-8674(76)90027-1  0.365
1975 Maniatis T, Ptashne M, Backman K, Kield D, Flashman S, Jeffrey A, Maurer R. Recognition sequences of repressor and polymerase in the operators of bacteriophage lambda. Cell. 5: 109-13. PMID 1095210 DOI: 10.1016/0092-8674(75)90018-5  0.577
1975 Maniatis T, Jeffrey A, Kleid DG. Nucleotide sequence of the rightward operator of phage lambda. Proceedings of the National Academy of Sciences of the United States of America. 72: 1184-8. PMID 1055375 DOI: 10.1073/PNAS.72.3.1184  0.307
1975 Efstratiadis A, Maniatis T, Kafatos FC, Jeffrey A, Vournakis JN. Full length and discrete partial reverse transcripts of globin and chorion mRNAs. Cell. 4: 367-78. PMID 47272 DOI: 10.1016/0092-8674(75)90157-9  0.33
1974 Maniatis T, Ptashne M, Barrell BG, Donelson J. Sequence of a repressor-binding site in the DNA of bacteriophage lamda. Nature. 250: 394-7. PMID 4854243 DOI: 10.1038/250394A0  0.585
1974 Maurer R, Maniatis T, Ptashne M. Promoters are in the operators in phage lambda. Nature. 249: 221-3. PMID 4598033 DOI: 10.1038/249221A0  0.562
1974 Maniatis T, Ptashne M, Maurer R. Control elements in the DNA of bacteriophage lambda. Cold Spring Harbor Symposia On Quantitative Biology. 38: 857-68. PMID 4545512 DOI: 10.1101/Sqb.1974.038.01.088  0.52
1974 Maniatis T, Venable JH, Lerman LS. The structure of psi DNA. Journal of Molecular Biology. 84: 37-64. PMID 4208607 DOI: 10.1016/0022-2836(74)90211-3  0.628
1973 Maniatis T, Ptashne M. Structure of the lambda operators. Nature. 246: 133-6. PMID 4586104 DOI: 10.1038/246133A0  0.554
1973 Maniatis T, Ptashne M. Multiple repressor binding at the operators in bacteriophage lambda. Proceedings of the National Academy of Sciences of the United States of America. 70: 1531-5. PMID 4514322 DOI: 10.1073/Pnas.70.5.1531  0.532
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