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Polina V. Shcherbakova - Publications

Affiliations: 
Cancer Research University of Nebraska Medical Center, Omaha, NE, United States 
Area:
Biochemistry, Genetics
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40 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Ostroverkhova D, Tyryshkin K, Beach AK, Moore EA, Masoudi-Sobhanzadeh Y, Barbari SR, Rogozin IB, Shaitan KV, Panchenko AR, Shcherbakova PV. DNA polymerase ε and δ variants drive mutagenesis in polypurine tracts in human tumors. Cell Reports. 43: 113655. PMID 38219146 DOI: 10.1016/j.celrep.2023.113655  0.388
2022 Barbari SR, Beach AK, Markgren JG, Parkash V, Moore EA, Johansson E, Shcherbakova PV. Enhanced polymerase activity permits efficient synthesis by cancer-associated DNA polymerase ϵ variants at low dNTP levels. Nucleic Acids Research. PMID 35822874 DOI: 10.1093/nar/gkac602  0.61
2021 Stepchenkova EI, Zhuk AS, Cui J, Tarakhovskaya ER, Barbari SR, Shcherbakova PV, Polev DE, Fedorov R, Poliakov E, Rogozin IB, Lada AG, Pavlov YI. Compensation for the absence of the catalytically active half of DNA polymerase ε in yeast by positively selected mutations in CDC28. Genetics. PMID 33844024 DOI: 10.1093/genetics/iyab060  0.608
2020 Bulock CR, Xing X, Shcherbakova PV. Mismatch repair and DNA polymerase δ proofreading prevent catastrophic accumulation of leading strand errors in cells expressing a cancer-associated DNA polymerase ϵ variant. Nucleic Acids Research. PMID 32756902 DOI: 10.1093/Nar/Gkaa633  0.724
2020 Lee M, Eng G, Barbari SR, Deshpande V, Shcherbakova PV, Gala MK. Homologous Recombination Repair Truncations Predict Hypermutation in Microsatellite Stable Colorectal and Endometrial Tumors. Clinical and Translational Gastroenterology. 11: e00149. PMID 32352724 DOI: 10.14309/Ctg.0000000000000149  0.393
2020 Bulock CR, Xing X, Shcherbakova PV. DNA polymerase δ proofreads errors made by DNA polymerase ε. Proceedings of the National Academy of Sciences of the United States of America. PMID 32123096 DOI: 10.1073/Pnas.1917624117  0.645
2019 Parkash V, Kulkarni Y, Ter Beek J, Shcherbakova PV, Kamerlin SCL, Johansson E. Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase ε. Nature Communications. 10: 373. PMID 30670696 DOI: 10.1038/S41467-018-08114-9  0.627
2019 Xing X, Kane DP, Bulock CR, Moore EA, Sharma S, Chabes A, Shcherbakova PV. A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme. Nature Communications. 10: 374. PMID 30670691 DOI: 10.1038/S41467-018-08145-2  0.696
2018 Barbari SR, Kane DP, Moore EA, Shcherbakova PV. Functional Analysis of Cancer-Associated DNA Polymerase ε Variants in Saccharomyces cerevisiae. G3 (Bethesda, Md.). PMID 29352080 DOI: 10.1534/G3.118.200042  0.674
2017 Barbari SR, Shcherbakova PV. Replicative DNA polymerase defects in human cancers: Consequences, mechanisms, and implications for therapy. Dna Repair. PMID 28687338 DOI: 10.1016/J.Dnarep.2017.06.003  0.743
2017 Mertz TM, Baranovskiy AG, Wang J, Tahirov TH, Shcherbakova PV. Nucleotide selectivity defect and mutator phenotype conferred by a colon cancer-associated DNA polymerase δ mutation in human cells. Oncogene. 36: 4427-4433. PMID 28368425 DOI: 10.1038/onc.2017.22  0.469
2017 Kochenova OV, Bezalel-Buch R, Tran P, Makarova AV, Chabes A, Burgers PM, Shcherbakova PV. Yeast DNA polymerase ζ maintains consistent activity and mutagenicity across a wide range of physiological dNTP concentrations. Nucleic Acids Research. 45: 1200-1218. PMID 28180291 DOI: 10.1093/Nar/Gkw1149  0.677
2016 Kochenova OV, Bezalel-Buch R, Tran P, Makarova AV, Chabes A, Burgers PM, Shcherbakova PV. Yeast DNA polymerase ζ maintains consistent activity and mutagenicity across a wide range of physiological dNTP concentrations. Nucleic Acids Research. PMID 27903904 DOI: 10.1093/nar/gkw1149  0.611
2015 Mertz TM, Sharma S, Chabes A, Shcherbakova PV. Colon cancer-associated mutator DNA polymerase δ variant causes expansion of dNTP pools increasing its own infidelity. Proceedings of the National Academy of Sciences of the United States of America. 112: E2467-76. PMID 25827231 DOI: 10.1073/Pnas.1422934112  0.666
2015 Kochenova OV, Daee DL, Mertz TM, Shcherbakova PV. DNA polymerase ζ-dependent lesion bypass in Saccharomyces cerevisiae is accompanied by error-prone copying of long stretches of adjacent DNA. Plos Genetics. 11: e1005110. PMID 25826305 DOI: 10.1371/Journal.Pgen.1005110  0.611
2014 Kane DP, Shcherbakova PV. A common cancer-associated DNA polymerase ε mutation causes an exceptionally strong mutator phenotype, indicating fidelity defects distinct from loss of proofreading. Cancer Research. 74: 1895-901. PMID 24525744 DOI: 10.1158/0008-5472.Can-13-2892  0.607
2014 Northam MR, Moore EA, Mertz TM, Binz SK, Stith CM, Stepchenkova EI, Wendt KL, Burgers PM, Shcherbakova PV. DNA polymerases ζ and Rev1 mediate error-prone bypass of non-B DNA structures. Nucleic Acids Research. 42: 290-306. PMID 24049079 DOI: 10.1093/Nar/Gkt830  0.753
2013 Kadyrova LY, Mertz TM, Zhang Y, Northam MR, Sheng Z, Lobachev KS, Shcherbakova PV, Kadyrov FA. A reversible histone H3 acetylation cooperates with mismatch repair and replicative polymerases in maintaining genome stability. Plos Genetics. 9: e1003899. PMID 24204308 DOI: 10.1371/Journal.Pgen.1003899  0.711
2012 Shah KA, Shishkin AA, Voineagu I, Pavlov YI, Shcherbakova PV, Mirkin SM. Role of DNA polymerases in repeat-mediated genome instability. Cell Reports. 2: 1088-95. PMID 23142667 DOI: 10.1016/J.Celrep.2012.10.006  0.75
2011 Sharma NM, Kochenova OV, Shcherbakova PV. The non-canonical protein binding site at the monomer-monomer interface of yeast proliferating cell nuclear antigen (PCNA) regulates the Rev1-PCNA interaction and Polζ/Rev1-dependent translesion DNA synthesis. The Journal of Biological Chemistry. 286: 33557-66. PMID 21799021 DOI: 10.1074/Jbc.M110.206680  0.64
2011 Kochenova OV, Soshkina JV, Stepchenkova EI, Inge-Vechtomov SG, Shcherbakova PV. Participation of translesion synthesis DNA polymerases in the maintenance of chromosome integrity in yeast Saccharomyces cerevisiae. Biochemistry. Biokhimiia. 76: 49-60. PMID 21568839 DOI: 10.1134/S000629791101007X  0.529
2010 Daee DL, Mertz TM, Shcherbakova PV. A cancer-associated DNA polymerase delta variant modeled in yeast causes a catastrophic increase in genomic instability. Proceedings of the National Academy of Sciences of the United States of America. 107: 157-62. PMID 19966286 DOI: 10.1073/Pnas.0907526106  0.574
2010 Northam MR, Robinson HA, Kochenova OV, Shcherbakova PV. Participation of DNA polymerase zeta in replication of undamaged DNA in Saccharomyces cerevisiae. Genetics. 184: 27-42. PMID 19841096 DOI: 10.1534/Genetics.109.107482  0.756
2010 Pavlov YI, Shcherbakova PV. DNA polymerases at the eukaryotic fork-20 years later. Mutation Research. 685: 45-53. PMID 19682465 DOI: 10.1016/J.Mrfmmm.2009.08.002  0.689
2006 Pavlov YI, Shcherbakova PV, Rogozin IB. Roles of DNA polymerases in replication, repair, and recombination in eukaryotes. International Review of Cytology. 255: 41-132. PMID 17178465 DOI: 10.1016/S0074-7696(06)55002-8  0.745
2006 Northam MR, Garg P, Baitin DM, Burgers PM, Shcherbakova PV. A novel function of DNA polymerase zeta regulated by PCNA. The Embo Journal. 25: 4316-25. PMID 16957771 DOI: 10.1038/Sj.Emboj.7601320  0.756
2006 Shcherbakova PV, Fijalkowska IJ. Translesion synthesis DNA polymerases and control of genome stability. Frontiers in Bioscience : a Journal and Virtual Library. 11: 2496-517. PMID 16720328  0.655
2006 Shcherbakova PV, Kunkel TA. 20 DNA Polymerases and the Fidelity of DNA Replication Cold Spring Harbor Monograph Archive. 47: 391-409. DOI: 10.1101/087969766.47.391  0.731
2003 Shcherbakova PV, Pavlov YI, Chilkova O, Rogozin IB, Johansson E, Kunkel TA. Unique error signature of the four-subunit yeast DNA polymerase epsilon. The Journal of Biological Chemistry. 278: 43770-80. PMID 12882968 DOI: 10.1074/Jbc.M306893200  0.653
2003 Shcherbakova PV, Bebenek K, Kunkel TA. Functions of eukaryotic DNA polymerases. Science of Aging Knowledge Environment : Sage Ke. 2003: RE3. PMID 12844548 DOI: 10.1126/Sageke.2003.8.Re3  0.742
2003 Hall MC, Shcherbakova PV, Fortune JM, Borchers CH, Dial JM, Tomer KB, Kunkel TA. DNA binding by yeast Mlh1 and Pms1: implications for DNA mismatch repair. Nucleic Acids Research. 31: 2025-34. PMID 12682353 DOI: 10.1093/Nar/Gkg324  0.655
2003 Hoffmann ER, Shcherbakova PV, Kunkel TA, Borts RH. MLH1 mutations differentially affect meiotic functions in Saccharomyces cerevisiae. Genetics. 163: 515-26. PMID 12618391  0.572
2002 Drotschmann K, Hall MC, Shcherbakova PV, Wang H, Erie DA, Brownewell FR, Kool ET, Kunkel TA. DNA binding properties of the yeast Msh2-Msh6 and Mlh1-Pms1 heterodimers. Biological Chemistry. 383: 969-75. PMID 12222686 DOI: 10.1515/Bc.2002.103  0.666
2002 Hall MC, Shcherbakova PV, Kunkel TA. Differential ATP binding and intrinsic ATP hydrolysis by amino-terminal domains of the yeast Mlh1 and Pms1 proteins. The Journal of Biological Chemistry. 277: 3673-9. PMID 11717305 DOI: 10.1074/Jbc.M106120200  0.388
2001 Shcherbakova PV, Hall MC, Lewis MS, Bennett SE, Martin KJ, Bushel PR, Afshari CA, Kunkel TA. Inactivation of DNA mismatch repair by increased expression of yeast MLH1. Molecular and Cellular Biology. 21: 940-51. PMID 11154280 DOI: 10.1128/Mcb.21.3.940-951.2001  0.646
2000 Drotschmann K, Shcherbakova PV, Kunkel TA. Mutator phenotype due to loss of heterozygosity in diploid yeast strains with mutations in MSH2 and MLH1. Toxicology Letters. 239-44. PMID 10720737 DOI: 10.1016/S0378-4274(99)00276-3  0.446
1999 Shcherbakova PV, Kunkel TA. Mutator phenotypes conferred by MLH1 overexpression and by heterozygosity for mlh1 mutations. Molecular and Cellular Biology. 19: 3177-83. PMID 10082584 DOI: 10.1128/Mcb.19.4.3177  0.505
1996 Pavlov YI, Suslov VV, Shcherbakova PV, Kunkel TA, Ono A, Matsuda A, Schaaper RM. Base analog N6-hydroxylaminopurine mutagenesis in Escherichia coli: Genetic control and molecular specificity Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 357: 1-15. PMID 8876675 DOI: 10.1016/0027-5107(96)00060-7  0.584
1996 Shcherbakova PV, Noskov VN, Pshenichnov MR, Pavlov YI. Base analog 6-N-hydroxylaminopurine mutagenesis in the yeast Saccharomyccs cerevisiae is controlled by replicative DNA polymerases Mutation Research - Genetic Toxicology. 369: 33-44. PMID 8700180 DOI: 10.1016/S0165-1218(96)90045-2  0.66
1993 Shcherbakova PV, Pavlov YI. Mutagenic specificity of the base analog 6-N-hydroxylaminopurine in the URA3 gene of the yeast Saccharomyces cerevisiae Mutagenesis. 8: 417-421. PMID 8231822 DOI: 10.1093/Mutage/8.5.417  0.445
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