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Edward B. Brown, Ph.D. - Publications

Affiliations: 
Biomedical Engineering University of Rochester, Rochester, NY 
Website:
http://www.urmc.rochester.edu/labs/Brown-Lab/
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64 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Desa DE, Wu W, Brown RM, Brown EB, Hill RL, Turner BM, Brown EB. Second-Harmonic Generation Imaging Reveals Changes in Breast Tumor Collagen Induced by Neoadjuvant Chemotherapy. Cancers. 14. PMID 35205605 DOI: 10.3390/cancers14040857  0.312
2019 Desa DE, Bhanote M, Hill RL, Majeski JB, Buscaglia B, D'Aguiar M, Strawderman R, Hicks DG, Turner BM, Brown EB. Second-harmonic generation directionality is associated with neoadjuvant chemotherapy response in breast cancer core needle biopsies. Journal of Biomedical Optics. 24: 1-9. PMID 31456385 DOI: 10.1117/1.Jbo.24.8.086503  0.324
2019 Desa D, Turner B, Buscaglia B, Hill R, Strawderman R, Hicks D, Brown E. Abstract P6-09-12: Using multiphoton laser scanning microscopy to assess neoadjuvant therapy outcome in core needle biopsies: A novel methodology Cancer Research. 79. DOI: 10.1158/1538-7445.Sabcs18-P6-09-12  0.374
2016 Choe R, Ramirez G, Proctor AR, Han S, Durduran T, Brown EB. Diffuse correlation spectroscopy and tomography for longitudinal monitoring of blood flow changes induced by chemotherapy in breast cancer xenografts Cancer. DOI: 10.1364/Cancer.2016.Ctu4A.4  0.35
2016 Dawes R, Byun D, Brown E, Madden K. Abstract # 1825 Beta-adrenergic receptor signaling constrains mammary tumor progression and modulates tumor-associated exosomes Brain, Behavior, and Immunity. 57: e33. DOI: 10.1016/J.Bbi.2016.07.110  0.391
2015 Burke K, Smid M, Dawes RP, Timmermans MA, Salzman P, van Deurzen CH, Beer DG, Foekens JA, Brown E. Using second harmonic generation to predict patient outcome in solid tumors. Bmc Cancer. 15: 929. PMID 26603532 DOI: 10.1186/S12885-015-1911-8  0.369
2015 Burke KA, Dawes RP, Cheema MK, Van Hove A, Benoit DS, Perry SW, Brown E. Second-harmonic generation scattering directionality predicts tumor cell motility in collagen gels. Journal of Biomedical Optics. 20: 051024. PMID 25625899 DOI: 10.1117/1.Jbo.20.5.051024  0.37
2015 Haynes-Gimore N, Banach M, Brown E, Dawes R, Edholm ES, Kim M, Robert J. Semi-solid tumor model in Xenopus laevis/gilli cloned tadpoles for intravital study of neovascularization, immune cells and melanophore infiltration. Developmental Biology. PMID 25601449 DOI: 10.1016/J.Ydbio.2015.01.003  0.386
2015 Sullivan KD, Majewska AK, Brown EB. Single- and two-photon fluorescence recovery after photobleaching. Cold Spring Harbor Protocols. 2015: pdb.top083519. PMID 25561627 DOI: 10.1101/Pdb.Top083519  0.673
2015 Dawes R, Byun D, Brown E, Madden K. Psychosocial stress suppresses tumor progression in a murine model of spontaneous, metastatic breast cancer Brain, Behavior, and Immunity. 49: e28. DOI: 10.1016/J.Bbi.2015.06.112  0.358
2014 Choe R, Jung KW, Kim HJ, Proctor AR, Byun DK, Farzam P, Madden KS, Durduran T, Brown EB. Quantification of early hemodynamic changes induced by cyclophosphamide on breast cancer xenografts using diffuse optics Ieee Transactions On Biomedical Engineering. DOI: 10.1364/Biomed.2014.Bs3A.10  0.326
2014 Burke KA, Dawes RP, Cheema MK, Perry S, Brown E. Second-harmonic generation reveals a relationship between metastatic potential and collagen fiber structure Progress in Biomedical Optics and Imaging - Proceedings of Spie. 8948. DOI: 10.1117/12.2041027  0.358
2014 Dawes R, Byun D, Brown E, Madden K. 71. A novel combined psychosocial stress paradigm alters tumor VEGF and circulating exosomes in a spontaneous, metastatic model of breast cancer Brain, Behavior, and Immunity. 40: e21. DOI: 10.1016/J.Bbi.2014.06.091  0.389
2014 Madden K, Dawes R, Byun D, Brown E. 20. ß2-Adrenergic agonist treatment inhibits 4T1 breast tumor metastasis to the lung Brain, Behavior, and Immunity. 40: e6. DOI: 10.1016/J.Bbi.2014.06.040  0.373
2013 Szpunar MJ, Burke KA, Dawes RP, Brown EB, Madden KS. The antidepressant desipramine and α2-adrenergic receptor activation promote breast tumor progression in association with altered collagen structure. Cancer Prevention Research (Philadelphia, Pa.). 6: 1262-72. PMID 24309563 DOI: 10.1158/1940-6207.Capr-13-0079  0.755
2013 Perry SW, Schueckler JM, Burke K, Arcuri GL, Brown EB. Stromal matrix metalloprotease-13 knockout alters Collagen I structure at the tumor-host interface and increases lung metastasis of C57BL/6 syngeneic E0771 mammary tumor cells. Bmc Cancer. 13: 411. PMID 24010522 DOI: 10.1186/1471-2407-13-411  0.397
2013 Burke RM, Madden KS, Perry SW, Zettel ML, Brown EB. Tumor-associated macrophages and stromal TNF-α regulate collagen structure in a breast tumor model as visualized by second harmonic generation. Journal of Biomedical Optics. 18: 86003. PMID 23912760 DOI: 10.1117/1.Jbo.18.8.086003  0.65
2013 Madden KS, Zettel ML, Majewska AK, Brown EB. Brain tumor imaging: imaging brain metastasis using a brain-metastasizing breast adenocarcinoma. Cold Spring Harbor Protocols. 2013. PMID 23457349 DOI: 10.1101/Pdb.Prot073676  0.347
2013 Madden KS, Zettel ML, Majewska AK, Brown EB. Brain tumor imaging: live imaging of glioma by two-photon microscopy. Cold Spring Harbor Protocols. 2013. PMID 23457348 DOI: 10.1101/Pdb.Prot073668  0.352
2013 Burke K, Tang P, Brown E. Second harmonic generation reveals matrix alterations during breast tumor progression. Journal of Biomedical Optics. 18: 31106. PMID 23172133 DOI: 10.1117/1.Jbo.18.3.031106  0.388
2013 Madden KS, Szpunar MJ, Brown EB. Early impact of social isolation and breast tumor progression in mice. Brain, Behavior, and Immunity. 30: S135-41. PMID 22610067 DOI: 10.1016/J.Bbi.2012.05.003  0.739
2013 Shapovalov Y, Amico-Ruvio SA, Spielman SC, Lamantia CE, Brown EB, Majewska AK. Abstract B091: Analysis of glial activation in a murine model of brain metastatic breast cancer Molecular Cancer Research. 11. DOI: 10.1158/1557-3125.Advbc-B091  0.356
2013 Dawes RP, Burke KA, Stastka P, Brown EB, Madden KS. Abstract A103: The neurotransmitter norepinephrine and β2-AR activation of MB-231 breast cancer cells alters fibrillar collagen structure Molecular Cancer Research. 11. DOI: 10.1158/1557-3125.Advbc-A103  0.4
2013 Burke KA, Brown E. Abstract 2825: Using SHG to study breast cancer tumor progression. Cancer Research. 73: 2825-2825. DOI: 10.1158/1538-7445.Am2013-2825  0.387
2012 Perry SW, Burke RM, Brown EB. Two-photon and second harmonic microscopy in clinical and translational cancer research. Annals of Biomedical Engineering. 40: 277-91. PMID 22258888 DOI: 10.1007/S10439-012-0512-9  0.574
2012 Soto JL, Madden KS, Brown EB. Abstract 5298: Abnormal VEGF-induced Ca2+ signaling in purified tumor endothelial cells Cancer Research. 72: 5298-5298. DOI: 10.1158/1538-7445.Am2012-5298  0.306
2012 Madden K, Szpunar M, Burke K, Byun D, Liverpool K, Brown E. 151. Evidence for sympathetic nervous system modulation of mammary tumor pathogenesis via tumor collagen Brain, Behavior, and Immunity. 26: S42. DOI: 10.1016/J.Bbi.2012.07.175  0.754
2011 Sullivan KD, Brown EB. Multiphoton fluorescence recovery after photobleaching in bounded systems. Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics. 83: 051916. PMID 21728580 DOI: 10.1103/Physreve.83.051916  0.68
2011 Madden KS, Szpunar MJ, Brown EB. β-Adrenergic receptors (β-AR) regulate VEGF and IL-6 production by divergent pathways in high β-AR-expressing breast cancer cell lines. Breast Cancer Research and Treatment. 130: 747-58. PMID 21234673 DOI: 10.1007/S10549-011-1348-Y  0.712
2011 Nagarajan MB, Han X, Huber MB, Foster TH, Brown EB, Wismüller A. Quantitative analysis of tumor matrix patterns through statistical and topological texture features Progress in Biomedical Optics and Imaging - Proceedings of Spie. 7965. DOI: 10.1117/12.878619  0.488
2011 Han X, Lapeira J, Burke R, Perry S, Madden K, Brown EB. In vivo imaging of tumors using multiphoton fluorescence and second harmonic generation Optics Infobase Conference Papers. DOI: 10.1101/Pdb.Prot5452  0.692
2011 Madden K, Szpunar M, Bouta E, Brown E. Detection of sympathetic tyrosine hydroxylase-positive (TH+) nerve fibers in orthotopic mammary tumors by multiphoton laser scanning microscopy (MPLSM) Brain, Behavior, and Immunity. 25: S228. DOI: 10.1016/J.Bbi.2011.07.172  0.712
2011 Szpunar M, Madden K, Liverpool K, Brown E. 157. Sympathetic nervous system innervation and function in a beta-adrenergic receptor negative breast cancer model Brain, Behavior, and Immunity. 25: S224. DOI: 10.1016/J.Bbi.2011.07.160  0.716
2011 Han X, Lapeira J, Burke R, Perry S, Madden K, Brown EB. In vivo imaging of tumors using multiphoton fluorescence and second harmonic generation Optics Infobase Conference Papers.  0.661
2010 Kozai TD, Marzullo TC, Hooi F, Langhals NB, Majewska AK, Brown EB, Kipke DR. Reduction of neurovascular damage resulting from microelectrode insertion into the cerebral cortex using in vivo two-photon mapping. Journal of Neural Engineering. 7: 046011. PMID 20644246 DOI: 10.1088/1741-2560/7/4/046011  0.685
2010 Han X, Brown E. Measurement of the ratio of forward-propagating to back-propagating second harmonic signal using a single objective. Optics Express. 18: 10538-50. PMID 20588906 DOI: 10.1364/Oe.18.010538  0.469
2010 Sullivan KD, Brown EB. Measuring diffusion coefficients via two-photon fluorescence recovery after photobleaching. Journal of Visualized Experiments : Jove. PMID 20190730 DOI: 10.3791/1636  0.679
2010 Han X, Brown E. Epi-detected ratio of forward-propagating to back-propagating second harmonic signal Optics Infobase Conference Papers. DOI: 10.1364/Fio.2010.Ftuf4  0.459
2010 Li J, Sullivan KD, Brown EB, Anthamatten M. Thermally activated diffusion in reversibly associating polymers Soft Matter. 6: 235-238. DOI: 10.1039/B909662K  0.648
2010 Sullivan KD, Brown EB. Measuring Diffusion Coefficients in Confined Systems Via Multi-Photon Fluorescence Recovery after Photobleaching Biophysical Journal. 98: 578a. DOI: 10.1016/J.Bpj.2009.12.3143  0.676
2010 Madden K, Szpunar M, Fitzgerald K, Brown E. Beta-adrenergic receptors, cAMP and proangiogenic factor production by breast cancer cell lines Brain, Behavior, and Immunity. 24: S41-S42. DOI: 10.1016/J.Bbi.2010.07.137  0.715
2010 Szpunar M, Madden K, Liverpool K, Brown E. Evidence for sympathetic nervous system regulation of breast cancer pathogenesis Brain, Behavior, and Immunity. 24: S40. DOI: 10.1016/J.Bbi.2010.07.132  0.709
2009 Chauhan VP, Lanning RM, Diop-Frimpong B, Mok W, Brown EB, Padera TP, Boucher Y, Jain RK. Multiscale measurements distinguish cellular and interstitial hindrances to diffusion in vivo. Biophysical Journal. 97: 330-6. PMID 19580771 DOI: 10.1016/J.Bpj.2009.03.064  0.344
2009 Sullivan KD, Sipprell WH, Brown EB, Brown EB. Improved model of fluorescence recovery expands the application of multiphoton fluorescence recovery after photobleaching in vivo. Biophysical Journal. 96: 5082-94. PMID 19527668 DOI: 10.1016/J.Bpj.2009.04.020  0.684
2009 Szpunar M, Madden K, Brown E. 120. Heterogeneity of β-adrenergic receptor (β-AR) signal transduction and vascular endothelial growth factor (VEGF) production by breast cancer cell lines Brain, Behavior, and Immunity. 23: S58. DOI: 10.1016/J.Bbi.2009.06.125  0.706
2009 Madden K, Szpunar M, Brown E. 82. Beta-adrenergic receptor (beta-AR) signaling differs between the human breast cancer cell line MB-231 and its brain-metastasizing variant MB-231BR Brain, Behavior, and Immunity. 23: S47-S48. DOI: 10.1016/J.Bbi.2009.06.087  0.712
2008 Han X, Burke RM, Zettel ML, Tang P, Brown EB. Second harmonic properties of tumor collagen: determining the structural relationship between reactive stroma and healthy stroma. Optics Express. 16: 1846-59. PMID 18542263 DOI: 10.1364/Oe.16.001846  0.691
2008 Han X, Burke RM, Zettel ML, Tang P, Brown EB. Assessment of Second Harmonic Properties of Tumor Collagen Frontiers in Optics. DOI: 10.1364/Fio.2008.Jsua14  0.69
2008 Han X, Burke RM, Brown EB. Assessment of second harmonic properties of tumor collagen: Determining the structural relationship between reactive stroma and healthy stroma Biomedical Optics, Biomed 2008. BTuF60. DOI: 10.1364/Biomed.2008.Btuf60  0.689
2008 Han X, Burke RM, Brown EB. Assessment of second harmonic properties of tumor collagen: Determining the structural relationship between reactive stroma and healthy stroma Biomedical Optics, Biomed 2008. BTuF60.  0.659
2008 Han X, Burke RM, Brown EB. Assessment of second harmonic properties of tumor collagen: Determining the structural relationship between reactive stroma and healthy stroma Biomedical Optics, Biomed 2008. BTuF60.  0.659
2005 Stroh M, Zimmer JP, Duda DG, Levchenko TS, Cohen KS, Brown EB, Scadden DT, Torchilin VP, Bawendi MG, Fukumura D, Jain RK. Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo. Nature Medicine. 11: 678-82. PMID 15880117 DOI: 10.1038/Nm1247  0.367
2004 Duda DG, Fukumura D, Munn LL, Booth MF, Brown EB, Huang P, Seed B, Jain RK. Differential transplantability of tumor-associated stromal cells. Cancer Research. 64: 5920-4. PMID 15342367 DOI: 10.1158/0008-5472.Can-04-1268  0.334
2004 Brown EB, Boucher Y, Nasser S, Jain RK. Measurement of macromolecular diffusion coefficients in human tumors. Microvascular Research. 67: 231-6. PMID 15121448 DOI: 10.1016/J.Mvr.2004.02.001  0.362
2004 Alexandrakis G, Brown EB, Tong RT, McKee TD, Campbell RB, Boucher Y, Jain RK. Two-photon fluorescence correlation microscopy reveals the two-phase nature of transport in tumors. Nature Medicine. 10: 203-7. PMID 14716306 DOI: 10.1038/Nm981  0.384
2004 Tyrrell JA, Mahadevan V, Tong R, Roysam B, Brown EB, Jain RK. Robust parametric modeling for improved segmentation of complex tumor microvasculature from multiphoton microscopy data Microscopy and Microanalysis. 10: 176-177. DOI: 10.1017/S1431927604885787  0.311
2003 Brown E, McKee T, diTomaso E, Pluen A, Seed B, Boucher Y, Jain RK. Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation. Nature Medicine. 9: 796-800. PMID 12754503 DOI: 10.1038/Nm879  0.393
2003 Abdul-Karim MA, Al-Kofahi O, Brown EB, Jain RK, Al-Kofahi K, Roysam B. Automated in vivo change analysis of tumor vasculature from two-photon confocal image time series Proceedings of Spie - the International Society For Optical Engineering. 4963: 151-159. DOI: 10.1117/12.477991  0.343
2003 Brown E. Tumor Pathophysiology studied with Multiphoton Laser-Scanning Microscopy Microscopy and Microanalysis. 9: 1142-1143. DOI: 10.1017/S1431927603445716  0.334
2002 Ramanujan S, Pluen A, McKee TD, Brown EB, Boucher Y, Jain RK. Diffusion and convection in collagen gels: implications for transport in the tumor interstitium. Biophysical Journal. 83: 1650-60. PMID 12202388 DOI: 10.1016/S0006-3495(02)73933-7  0.367
2002 Padera TP, Kadambi A, di Tomaso E, Carreira CM, Brown EB, Boucher Y, Choi NC, Mathisen D, Wain J, Mark EJ, Munn LL, Jain RK. Lymphatic metastasis in the absence of functional intratumor lymphatics. Science (New York, N.Y.). 296: 1883-6. PMID 11976409 DOI: 10.1126/Science.1071420  0.356
2001 Brown EB, Campbell RB, Tsuzuki Y, Xu L, Carmeliet P, Fukumura D, Jain RK. In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy. Nature Medicine. 7: 864-8. PMID 11433354 DOI: 10.1038/89997  0.367
2001 Pluen A, Boucher Y, Ramanujan S, McKee TD, Gohongi T, di Tomaso E, Brown EB, Izumi Y, Campbell RB, Berk DA, Jain RK. Role of tumor-host interactions in interstitial diffusion of macromolecules: cranial vs. subcutaneous tumors. Proceedings of the National Academy of Sciences of the United States of America. 98: 4628-33. PMID 11274375 DOI: 10.1073/Pnas.081626898  0.393
1999 Brown EB, Wu ES, Zipfel W, Webb WW. Measurement of molecular diffusion in solution by multiphoton fluorescence photobleaching recovery. Biophysical Journal. 77: 2837-49. PMID 10545381 DOI: 10.1016/S0006-3495(99)77115-8  0.305
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