Roger M. Perlmutter - Publications

Affiliations: 
University of Washington, Seattle, Seattle, WA 
Area:
Molecular Biology, Genetics, Cell Biology

79 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2007 Garrett-Engele CM, Tasch MA, Hwang HC, Fero ML, Perlmutter RM, Clurman BE, Roberts JM. A mechanism misregulating p27 in tumors discovered in a functional genomic screen. Plos Genetics. 3: e219. PMID 18069898 DOI: 10.1371/Journal.Pgen.0030219  0.747
2003 Takaki S, Tezuka Y, Sauer K, Kubo C, Kwon SM, Armstead E, Nakao K, Katsuki M, Perlmutter RM, Takatsu K. Impaired lymphopoiesis and altered B cell subpopulations in mice overexpressing Lnk adaptor protein. Journal of Immunology (Baltimore, Md. : 1950). 170: 703-10. PMID 12517931 DOI: 10.4049/Jimmunol.170.2.703  0.334
2001 Sauer K, Liou J, Singh SB, Yablonski D, Weiss A, Perlmutter RM. Hematopoietic progenitor kinase 1 associates physically and functionally with the adaptor proteins B cell linker protein and SLP-76 in lymphocytes. The Journal of Biological Chemistry. 276: 45207-16. PMID 11487585 DOI: 10.1074/Jbc.M106811200  0.407
2001 Doerfler P, Shearman MS, Perlmutter RM. Presenilin-dependent γ-secretase activity modulates thymocyte development Proceedings of the National Academy of Sciences of the United States of America. 98: 9312-9317. PMID 11470902 DOI: 10.1073/Pnas.161102498  0.353
2001 Yamada A, Takaki S, Hayashi F, Georgopoulos K, Perlmutter RM, Takatsu K. Identification and characterization of a transcriptional regulator for the lck proximal promoter Journal of Biological Chemistry. 276: 18082-18089. PMID 11278409 DOI: 10.1074/Jbc.M008387200  0.494
2001 Sohn SJ, Forbush KA, Pan XC, Perlmutter RM. Activated p56lck directs maturation of both CD4 and CD8 single-positive thymocytes. Journal of Immunology (Baltimore, Md. : 1950). 166: 2209-17. PMID 11160274 DOI: 10.4049/jimmunol.166.4.2209  0.344
2000 Takaki S, Sauer K, Iritani BM, Chien S, Ebihara Y, Tsuji Ki, Takatsu K, Perlmutter RM. Control of B cell production by the adaptor protein Lnk: Definition of a conserved family of signal-modulating proteins Immunity. 13: 599-609. PMID 11114373 DOI: 10.1016/S1074-7613(00)00060-1  0.423
2000 Farrar MA, Tian J, Perlmutter RM. Membrane localization of Raf assists engagement of downstream effectors Journal of Biological Chemistry. 275: 31318-31324. PMID 10913130 DOI: 10.1074/Jbc.M003399200  0.337
1999 Seavitt JR, White LS, Murphy KM, Loh DY, Perlmutter RM, Thomas ML. Expression of the p56(lck) Y505F mutation in CD45-deficient mice rescues thymocyte development Molecular and Cellular Biology. 19: 4200-4208. PMID 10330160  0.306
1999 Page ST, Bogatzki LY, Hamerman JA, Malissen M, Perlmutter RM, Pullen AM. Differential effects of manipulating signaling in early T cell development in intestinal intraepithelial lymphocytes and thymocytes International Immunology. 11: 169-177. PMID 10069415 DOI: 10.1093/Intimm/11.2.169  0.322
1999 Yamashita M, Kimura M, Kubo M, Shimizu C, Tada T, Perlmutter RM, Nakayama T. T cell antigen receptor-mediated activation of the Ras/mitogen-activated protein kinase pathway controls interleukin 4 receptor function and type-2 helper T cell differentiation Proceedings of the National Academy of Sciences of the United States of America. 96: 1024-1029. PMID 9927687 DOI: 10.1073/Pnas.96.3.1024  0.424
1998 Alberola-lla J, Levin SD, Barton G, Forbush K, Zon LI, Perlmutter RM. Analysis of the pole of MKK-4/Sek-1 in T cell development and apoptosis International Immunology. 10: 1077-1082. PMID 9723693 DOI: 10.1093/Intimm/10.8.1077  0.489
1998 Page ST, Bogatzki LY, Hamerman JA, Sweenie CH, Hogarth PJ, Malissen M, Perlmutter RM, Pullen AM. Intestinal intraepithelial lymphocytes include precursors committed to the T cell receptor αβ lineage Proceedings of the National Academy of Sciences of the United States of America. 95: 9459-9464. PMID 9689102 DOI: 10.1073/Pnas.95.16.9459  0.446
1997 Iritani BM, Forbush KA, Farrar MA, Perlmutter RM. Control of B cell development by Ras-mediated activation of Raf Embo Journal. 16: 7019-7031. PMID 9384581 DOI: 10.1093/Emboj/16.23.7019  0.359
1997 Fehling HJ, Iritani BM, Krotkova A, Forbush KA, Laplace C, Perlmutter RM, von Boehmer H. Restoration of thymopoiesis in pT alpha-/- mice by anti-CD3epsilon antibody treatment or with transgenes encoding activated Lck or tailless pT alpha. Immunity. 6: 703-14. PMID 9208843 DOI: 10.1016/S1074-7613(00)80446-X  0.363
1997 Takaki S, Watts JD, Forbush KA, Nguyen NT, Hayashi J, Alberola-Ila J, Aebersold R, Perlmutter RM. Characterization of Lnk. An adaptor protein expressed in lymphocytes. The Journal of Biological Chemistry. 272: 14562-70. PMID 9169414 DOI: 10.1074/jbc.272.23.14562  0.447
1997 Alberola-Ila J, Takaki S, Kerner JD, Perlmutter RM. Differential signaling by lymphocyte antigen receptors. Annual Review of Immunology. 15: 125-54. PMID 9143684 DOI: 10.1146/Annurev.Immunol.15.1.125  0.325
1997 Hashimoto K, Sohn SJ, Levin SD, Tada T, Perlmutter RM, Nakayama T. Requirement for p56lck tyrosine kinase activation in T cell receptor-mediated thymic selection. The Journal of Experimental Medicine. 184: 931-43. PMID 9064353 DOI: 10.1084/JEM.184.3.931  0.387
1997 Page ST, Van Oers NSC, Perlmutter RM, Weiss A, Pullen AM. Differential contribution of Lck and Fyn protein tyrosine kinases to intraepithelial lymphocyte development European Journal of Immunology. 27: 554-562. PMID 9045930 DOI: 10.1002/Eji.1830270229  0.455
1997 Chen X, Martin F, Forbush KA, Perlmutter RM, Kearney JF. Evidence for selection of a population of multi-reactive B cells into the splenic marginal zone International Immunology. 9: 27-41. PMID 9043945 DOI: 10.1093/Intimm/9.1.27  0.354
1996 Groves T, Smiley P, Cooke MP, Forbush K, Perlmutter RM, Guidos CJ. Fyn can partially substitute for Lck in T lymphocyte development Immunity. 5: 417-428. PMID 8934569 DOI: 10.1016/S1074-7613(00)80498-7  0.467
1996 Farrar MA, Alberola-Ila J, Perlmutter RM. Activation of the Raf-1 kinase cascade by coumermycin-induced dimerization Nature. 383: 178-181. PMID 8774884 DOI: 10.1038/383178A0  0.377
1996 Alberola-Ila J, Hogquist KA, Swan KA, Bevan MJ, Perlmutter RM. Positive and negative selection invoke distinct signaling pathways Journal of Experimental Medicine. 184: 9-18. PMID 8691153 DOI: 10.1084/Jem.184.1.9  0.332
1996 Fero ML, Rivkin M, Tasch M, Porter P, Carow CE, Firpo E, Polyak K, Tsai LH, Broudy V, Perlmutter RM, Kaushansky K, Roberts JM. A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice. Cell. 85: 733-44. PMID 8646781 DOI: 10.1016/S0092-8674(00)81239-8  0.753
1995 Anderson SJ, Perlmutter RM. A signaling pathway governing early thymocyte maturation. Immunology Today. 16: 99-105. PMID 7888074 DOI: 10.1016/0167-5699(95)80096-4  0.421
1995 Alberola-Ila J, Forbush KA, Seger R, Krebs EG, Perlmutter RM. Selective requirement for MAP kinase activation in thymocyte differentiation. Nature. 373: 620-3. PMID 7854419 DOI: 10.1038/373620A0  0.625
1995 Gross JA, Appleby MW, Chien S, Nada S, Bartelmez SH, Okada M, Aizawa S, Perlmutter RM. Control of lymphopoiesis by p50csk, a regulatory protein tyrosine kinase. The Journal of Experimental Medicine. 181: 463-73. PMID 7836905 DOI: 10.1084/Jem.181.2.463  0.529
1995 Miyazaki T, Liu ZJ, Kawahara A, Minami Y, Yamada K, Tsujimoto Y, Barsoumian EL, Perlmutter RM, Taniguchi T. Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation Cell. 81: 223-231. PMID 7736574 DOI: 10.1016/0092-8674(95)90332-1  0.388
1995 Kerner JD, Appleby MW, Mohr RN, Chien S, Rawlings DJ, Maliszewski CR, Witte ON, Perlmutter RM. Impaired expansion of mouse B cell progenitors lacking Btk. Immunity. 3: 301-12. PMID 7552995 DOI: 10.1016/1074-7613(95)90115-9  0.337
1995 Dziennis S, Van Etten R, Pahl H, Morris D, Rothstein T, Blosch C, Perlmutter R, Tenen D. The CD11b promoter directs high-level expression of reporter genes in macrophages in transgenic mice [published erratum appears in Blood 1995 Apr 1;85(7):1983] Blood. 85: 319-329. DOI: 10.1182/Blood.V85.2.319.Bloodjournal852319  0.313
1995 Swan K, Alberola-Ila J, Gross J, Appleby M, Forbush K, Thomas J, Perlmutter R. Involvement of p21ras distinguishes positive and negative selection in thymocytes. The Embo Journal. 14: 276-285. DOI: 10.1002/J.1460-2075.1995.Tb07001.X  0.391
1994 Anderson SJ, Levin SD, Perlmutter RM. Involvement of the protein tyrosine kinase p56lck in T cell signaling and thymocyte development. Advances in Immunology. 56: 151-78. PMID 8073946 DOI: 10.1016/S0065-2776(08)60451-4  0.547
1994 Perlmutter RM. Zapping T-cell responses Nature. 370: 249-250. PMID 8035869 DOI: 10.1038/370249A0  0.353
1994 Mombaerts P, Anderson SJ, Perlmutter RM, Mak TW, Tonegawa S. An activated lck transgene promotes thymocyte development in RAG-1 mutant mice. Immunity. 1: 261-7. PMID 7889413 DOI: 10.1016/1074-7613(94)90077-9  0.402
1994 Perlmutter RM, Anderson SJ. Control of lymphopoiesis by non-receptor protein tyrosine kinases. Advances in Experimental Medicine and Biology. 365: 121-30. PMID 7887298 DOI: 10.1007/978-1-4899-0987-9_13  0.388
1994 Shibuya H, Kohu K, Yamada K, Barsoumian EL, Perlmutter RM, Taniguchi T. Functional dissection of p56lck, a protein tyrosine kinase which mediates interleukin-2-induced activation of the c-fos gene. Molecular and Cellular Biology. 14: 5812-5819. DOI: 10.1128/MCB.14.9.5812  0.35
1993 Perlmutter RM. In Vivo Dissection of Lymphocyte Signaling Pathways Clinical Immunology and Immunopathology. 67. PMID 8500281 DOI: 10.1006/Clin.1993.1083  0.457
1993 Perlmutter RM, Levin SD, Appleby MW, Anderson SJ, Alberola-Ila J. Regulation of lymphocyte function by protein phosphorylation. Annual Review of Immunology. 11: 451-99. PMID 8476569 DOI: 10.1146/Annurev.Iy.11.040193.002315  0.482
1993 Perlmutter RM. Molecular dissection of lymphocyte signal transduction pathways. Pediatric Research. 33: S9-13; discussion S1. PMID 8433881 DOI: 10.1203/00006450-199305001-00041  0.535
1993 Anderson SJ, Levin SD, Perlmutter RM. Protein tyrosine kinase p56lck controls allelic exclusion of T-cell receptor beta-chain genes. Nature. 365: 552-4. PMID 8413611 DOI: 10.1038/365552A0  0.406
1993 Levin SD, Abraham KM, Anderson SJ, Forbush KA, Perlmutter RM. The protein tyrosine kinase p56lck regulates thymocyte development independently of its interaction with CD4 and CD8 coreceptors [corrected]. The Journal of Experimental Medicine. 178: 245-55. PMID 8391060 DOI: 10.1084/Jem.178.1.245  0.434
1993 Nakayama T, Wiest DL, Abraham KM, Munitz TI, Perlmutter RM, Singer A. Decreased signaling competence as a result of receptor overexpression: overexpression of CD4 reduces its ability to activate p56lck tyrosine kinase and to regulate T-cell antigen receptor expression in immature CD4+CD8+ thymocytes. Proceedings of the National Academy of Sciences of the United States of America. 90: 10534-8. PMID 7902564 DOI: 10.1073/Pnas.90.22.10534  0.351
1993 Levin SD, Anderson SJ, Forbush KA, Perlmutter RM. A dominant-negative transgene defines a role for p56lck in thymopoiesis. The Embo Journal. 12: 1671-1680. DOI: 10.1002/J.1460-2075.1993.Tb05812.X  0.495
1992 Perlmutter RM. Translational regulation of the lymphocyte-specific protein tyrosine kinase p56lck. Enzyme. 44: 214-24. PMID 2133653 DOI: 10.1159/000468759  0.451
1992 Allen JM, Forbush KA, Perlmutter RM. Functional dissection of the lck proximal promoter. Molecular and Cellular Biology. 12: 2758-68. PMID 1588967 DOI: 10.1128/Mcb.12.6.2758  0.494
1992 Appleby MW, Gross JA, Cooke MP, Levin SD, Qian X, Perlmutter RM. Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn. Cell. 70: 751-63. PMID 1516132 DOI: 10.1016/0092-8674(92)90309-Z  0.473
1992 Van Oers NSC, Garvin AM, Cooke MP, Davis CB, Littman DR, Perlmutter RM, Teh HS. Differential involvement of protein tyrosine kinases p56(lck) and p59(fyn) in T cell development Advances in Experimental Medicine and Biology. 323: 89-100. PMID 1485568 DOI: 10.1007/978-1-4615-3396-2_12  0.366
1992 Anderson SJ, Abraham KM, Nakayama T, Singer A, Perlmutter RM. Inhibition of T-cell receptor beta-chain gene rearrangement by overexpression of the non-receptor protein tyrosine kinase p56lck. The Embo Journal. 11: 4877-4886. DOI: 10.1002/J.1460-2075.1992.Tb05594.X  0.407
1991 Wildin RS, Garvin AM, Pawar S, Lewis DB, Abraham KM, Forbush KA, Ziegler SF, Allen JM, Perlmutter RM. Developmental regulation of lck gene expression in T lymphocytes Journal of Experimental Medicine. 173: 383-393. PMID 1988541 DOI: 10.1084/Jem.173.2.383  0.509
1991 Biondi A, Paganin C, Rossi V, Benvestito S, Perlmutter RM, Mantovani A, Allavena P. Expression of lineage-restricted protein tyrosine kinase genes in human natural killer cells. European Journal of Immunology. 21: 843-846. PMID 1826268 DOI: 10.1002/Eji.1830210348  0.504
1991 Teh HS, Garvin AM, Forbush KA, Carlow DA, Davis CB, Littman DR, Perlmutter RM. Participation of CD4 coreceptor molecules in T-cell repertoire selection Nature. 349: 241-243. PMID 1824796 DOI: 10.1038/349241A0  0.386
1991 Lewis DB, Yu CC, Forbush KA, Carpenter J, Sato TA, Grossman A, Liggitt DH, Perlmutter RM. Interleukin 4 expressed in situ selectively alters thymocyte development. The Journal of Experimental Medicine. 173: 89-100. PMID 1824637 DOI: 10.1084/Jem.173.1.89  0.357
1991 Abraham KM, Levin SD, Marth JD, Forbush KA, Perlmutter RM. Delayed thymocyte development induced by augmented expression of p56lck Journal of Experimental Medicine. 173: 1421-1432. PMID 1709675 DOI: 10.1084/Jem.173.6.1421  0.751
1991 Abraham KM, Levin SD, Marth JD, Forbush KA, Perlmutter RM. Thymic tumorigenesis induced by overexpression of p56lck Proceedings of the National Academy of Sciences of the United States of America. 88: 3977-3981. PMID 1708890 DOI: 10.1073/Pnas.88.9.3977  0.753
1991 Chaffin KE, Perlmutter RM. A pertussis toxin-sensitive process controls thymocyte emigration. European Journal of Immunology. 21: 2565-2573. PMID 1655469 DOI: 10.1002/Eji.1830211038  0.426
1990 Hillson JL, Perlmutter RM. Autoantibodies and the Fetal Antibody Repertoire International Reviews of Immunology. 5: 215-229. PMID 2130118 DOI: 10.3109/08830189009056730  0.377
1990 Turner JM, Brodsky MH, Irving BA, Levin SD, Perlmutter RM, Littman DR. Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs. Cell. 60: 755-65. PMID 2107025 DOI: 10.1016/0092-8674(90)90090-2  0.367
1990 Garvin AM, Abraham KM, Forbush KA, Farr AG, Davison BL, Perlmutter RM. Disruption of thymocyte development and lymphomagenesis induced by SV4O T-antigen International Immunology. 2: 173-180. PMID 1965144 DOI: 10.1093/Intimm/2.2.173  0.508
1990 Perlmutter RM, Ziegler SF. Chapter 21 Portooncogene Expression following Lymphocyte Activation Current Topics in Membranes and Transport. 35: 571-586. DOI: 10.1016/S0070-2161(08)60093-3  0.448
1990 Chaffin KE, Beals CR, Wilkie TM, Forbush KA, Simon MI, Perlmutter RM. Dissection of thymocyte signaling pathways by in vivo expression of pertussis toxin ADP-ribosyltransferase. The Embo Journal. 9: 3821-3829. DOI: 10.1002/J.1460-2075.1990.Tb07600.X  0.456
1989 Perlmutter RM. T cell signaling Science. 245: 344-344. PMID 2787933 DOI: 10.1126/Science.2787933  0.358
1989 Ziegler SF, Levin SD, Perlmutter RM. Transformation of NIH 3T3 fibroblasts by an activated form of p59hck. Molecular and Cellular Biology. 9: 2724-7. PMID 2503711 DOI: 10.1128/Mcb.9.6.2724  0.491
1989 Perlmutter RM, Marth JD, Ziegler SF, Garvin AM, Pawar S, Cooke MP, Abraham KM. Specialized protein tyrosine kinase proto-oncogenes in hematopoietic cells Bba - Reviews On Cancer. 948: 245-262. PMID 2465780 DOI: 10.1016/0304-419X(89)90001-2  0.743
1989 Sartor O, Gregory FS, Templeton NS, Pawar S, Perlmutter RM, Rosen N. Selective expression of alternative lck mRNAs in human malignant cell lines. Molecular and Cellular Biology. 9: 2983-2988. DOI: 10.1128/MCB.9.7.2983  0.307
1988 Marth JD, Cooper JA, King CS, Ziegler SF, Tinker DA, Overell RW, Krebs EG, Perlmutter RM. Neoplastic transformation induced by an activated lymphocyte-specific protein tyrosine kinase (pp56lck). Molecular and Cellular Biology. 8: 540-50. PMID 3352600  0.772
1988 Marth JD, Overell RW, Meier KE, Krebs EG, Perlmutter RM. Translational activation of the lck proto-oncogene. Nature. 332: 171-3. PMID 3347254 DOI: 10.1038/332171A0  0.773
1988 Perlmutter RM, Marth JD, Lewis DB, Peet R, Ziegler SF, Wilson CB. Structure and expression of lck transcripts in human lymphoid cells Journal of Cellular Biochemistry. 38: 117-126. PMID 3265417 DOI: 10.1002/Jcb.240380206  0.693
1988 Louie RR, King CS, MacAuley A, Marth JD, Perlmutter RM, Eckhart W, Cooper JA. p56lck protein-tyrosine kinase is cytoskeletal and does not bind to polyomavirus middle T antigen. Journal of Virology. 62: 4673-9. PMID 3184274  0.699
1988 Ziegler SF, Wilson CB, Perlmutter RM. Augmented expression of a myeloid-specific protein tyrosine kinase gene (hck) after macrophage activation. The Journal of Experimental Medicine. 168: 1801-10. PMID 3141554 DOI: 10.1084/Jem.168.5.1801  0.537
1988 Garvin AM, Pawar S, Marth JD, Perlmutter RM. Structure of the murine lck gene and its rearrangement in a murine lymphoma cell line Molecular and Cellular Biology. 8: 3058-3064. PMID 2850479 DOI: 10.1128/Mcb.8.8.3058  0.742
1987 Ziegler SF, Marth JD, Lewis DB, Perlmutter RM. Novel protein-tyrosine kinase gene (hck) preferentially expressed in cells of hematopoietic origin Molecular and Cellular Biology. 7: 2276-2285. PMID 3453117 DOI: 10.1128/Mcb.7.6.2276  0.779
1987 Beals CR, Wilson CB, Perlmutter RM. A small multigene family encodes Gi signal-transduction proteins. Proceedings of the National Academy of Sciences of the United States of America. 84: 7886-7890. PMID 3120178 DOI: 10.1073/Pnas.84.22.7886  0.406
1987 Marth JD, Lewis DB, Wilson CB, Gearn ME, Krebs EG, Perlmutter RM. Regulation of pp56lck during T-cell activation: functional implications for the src-like protein tyrosine kinases. The Embo Journal. 6: 2727-34. PMID 3119327  0.785
1987 Schroeder HW, Hillson JL, Perlmutter RM. Early restriction of the human antibody repertoire Science. 238: 791-793. PMID 3118465 DOI: 10.1126/Science.3118465  0.402
1986 Marth JD, Disteche C, Pravtcheva D, Ruddle F, Krebs EG, Perlmutter RM. Localization of a lymphocyte-specific protein tyrosine kinase gene (lck) at a site of frequent chromosomal abnormalities in human lymphomas. Proceedings of the National Academy of Sciences of the United States of America. 83: 7400-4. PMID 3463975 DOI: 10.1073/Pnas.83.19.7400  0.761
1985 Perlmutter RM, Kearney JF, Chang SP, Hood LE. Developmentally controlled expression of immunoglobulin VH genes Science. 227: 1597-1601. PMID 3975629 DOI: 10.1126/Science.3975629  0.399
1985 Perlmutter RM, Berson B, Griffin JA, Hood L. Diversity in the germline antibody repertoire. Molecular evolution of the T15 VN gene family. The Journal of Experimental Medicine. 162: 1998-2016. PMID 2999288 DOI: 10.1084/Jem.162.6.1998  0.318
1985 Kofler R, Perlmutter RM, Noonan DJ, Dixon FJ, Theofilopoulos AN. Ig heavy chain variable region gene complex of lupus mice exhibits normal restriction fragment length polymorphism. The Journal of Experimental Medicine. 162: 346-51. PMID 2989410 DOI: 10.1084/Jem.162.1.346  0.379
1985 Marth JD, Peet R, Krebs EG, Perlmutter RM. A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA. Cell. 43: 393-404. PMID 2416464 DOI: 10.1016/0092-8674(85)90169-2  0.804
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