Elizabeth M. Nolan - Publications

Affiliations: 
Chemistry Massachusetts Institute of Technology, Cambridge, MA, United States 
Area:
metalloproteins
Website:
http://web.mit.edu/chemistry/www/faculty/nolan.html

78 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Rosen T, Hadley RC, Bozzi AT, Ocampo D, Shearer JM, Nolan EM. Zinc sequestration by human calprotectin facilitates manganese binding to the bacterial solute-binding proteins PsaA and MntC. Metallomics : Integrated Biometal Science. PMID 35090019 DOI: 10.1093/mtomcs/mfac001  0.308
2020 Zhang Y, Edmonds KA, Raines DJ, Murphy BA, Wu H, Guo C, Nolan EM, VanNieuwenhze MS, Duhme-Klair AK, Giedroc DP. The Pneumococcal Iron Uptake Protein a (PiuA) Specifically Recognizes Tetradentate Febis- and Mono-Catechol Complexes. Journal of Molecular Biology. PMID 32795535 DOI: 10.1016/J.Jmb.2020.08.005  0.311
2020 Rosen T, Nolan EM. Metal Sequestration and Antimicrobial Activity of Human Calprotectin Are pH-Dependent. Biochemistry. PMID 32491853 DOI: 10.1021/Acs.Biochem.0C00359  0.372
2019 Bozzi A, Nolan EM. Avian MRP126 Restricts Microbial Growth through Ca(II)-dependent Zn(II) Sequestration. Biochemistry. PMID 31886651 DOI: 10.1021/Acs.Biochem.9B01012  0.415
2019 Zygiel EM, Nolan EM. Exploring Iron Withholding by the Innate Immune Protein Human Calprotectin. Accounts of Chemical Research. PMID 31381301 DOI: 10.1021/Acs.Accounts.9B00250  0.373
2019 Hadley RC, Gagnon DM, Ozarowski A, Britt RD, Nolan EM. Murine Calprotectin Coordinates Mn(II) at a Hexahistidine Site with Ca(II)-Dependent Affinity. Inorganic Chemistry. PMID 31145609 DOI: 10.1021/Acs.Inorgchem.9B00763  0.4
2019 Gagnon DM, Hadley RC, Ozarowski A, Nolan EM, Britt RD. High‒Field EPR Spectroscopic Characterization of Mn(II) Bound to the Bacterial Solute-Binding Proteins MntC and PsaA. The Journal of Physical Chemistry. B. PMID 31117618 DOI: 10.1021/Acs.Jpcb.9B03633  0.369
2019 Hadley RC, Nolan EM. Preparation and Iron Redox Speciation Study of the Fe(II)-Binding Antimicrobial Protein Calprotectin. Methods in Molecular Biology (Clifton, N.J.). 1929: 397-415. PMID 30710287 DOI: 10.1007/978-1-4939-9030-6_25  0.366
2019 Cunden LS, Nolan EM. Preparation of the Oxidized and Reduced Forms of Psoriasin (S100A7). Methods in Molecular Biology (Clifton, N.J.). 1929: 379-395. PMID 30710286 DOI: 10.1007/978-1-4939-9030-6_24  0.365
2019 Zygiel EM, Nelson CE, Brewer LK, Oglesby-Sherrouse AG, Nolan EM. The human innate immune protein calprotectin induces iron starvation responses in . The Journal of Biological Chemistry. PMID 30622135 DOI: 10.1074/Jbc.Ra118.006819  0.35
2018 Richardson CER, Nolan EM, Shoulders MD, Lippard SJ. A sensitive, non-radioactive assay for Zn(II) uptake into metazoan cells. Biochemistry. PMID 30381945 DOI: 10.1021/Acs.Biochem.8B01043  0.494
2018 Stephan JR, Yu F, Costello RM, Bleier BS, Nolan EM. Oxidative Post-Translational Modifications Accelerate Proteolytic Degradation of Calprotectin. Journal of the American Chemical Society. PMID 30380834 DOI: 10.1021/Jacs.8B06354  0.348
2018 Lee HJ, Savelieff MG, Kang J, Brophy MB, Nakashige TG, Lee SJC, Nolan EM, Lim MH. Calprotectin influences the aggregation of metal-free and metal-bound amyloid-β by direct interaction. Metallomics : Integrated Biometal Science. PMID 30046785 DOI: 10.1039/C8Mt00091C  0.498
2018 Neumann W, Nolan EM. Evaluation of a reducible disulfide linker for siderophore-mediated delivery of antibiotics. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. PMID 29968176 DOI: 10.1007/S00775-018-1588-Y  0.339
2018 Zygiel EM, Nolan EM. Transition Metal Sequestration by the Host-Defense Protein Calprotectin. Annual Review of Biochemistry. 87: 621-643. PMID 29925260 DOI: 10.1146/Annurev-Biochem-062917-012312  0.328
2018 Nakashige TG, Bowman SEJ, Zygiel EM, Drennan CL, Nolan EM. Biophysical Examination of the Calcium-Modulated Nickel-Binding Properties of Human Calprotectin Reveals Conformational Change in the EF-Hand Domains and His3Asp Site. Biochemistry. PMID 29890074 DOI: 10.1021/Acs.Biochem.8B00415  0.388
2018 Hadley RC, Gu Y, Nolan EM. Initial Biochemical and Functional Evaluation of Murine Calprotectin Reveals Ca(II)-Dependence and Its Ability to Chelate Multiple Nutrient Transition Metal Ions. Biochemistry. PMID 29659256 DOI: 10.1021/Acs.Biochem.8B00309  0.384
2018 Neumann W, Sassone-Corsi M, Raffatellu M, Nolan EM. Esterase-Catalyzed Siderophore Hydrolysis Activates an Enterobactin-Ciprofloxacin Conjugate and Confers Targeted Antibacterial Activity. Journal of the American Chemical Society. PMID 29578687 DOI: 10.1021/Jacs.8B01042  0.326
2018 Cunden LS, Nolan EM. Bioinorganic Explorations of Zn(II) Sequestration by Human S100 Host-Defense Proteins. Biochemistry. PMID 29381858 DOI: 10.1021/Acs.Biochem.7B01305  0.405
2018 Richardson CER, Cunden LS, Butty VL, Nolan EM, Lippard SJ, Shoulders MD. A Method for Selective Depletion of Zn(II) Ions from Complex Biological Media and Evaluation of Cellular Consequences of Zn(II) Deficiency. Journal of the American Chemical Society. PMID 29334734 DOI: 10.1021/Jacs.7B12897  0.493
2017 Hadley RC, Gagnon DM, Brophy MB, Gu Y, Nakashige TG, Britt RD, Nolan EM. Biochemical and Spectroscopic Observation of Mn(II) Sequestration from Bacterial Mn(II) Transport Machinery by Calprotectin. Journal of the American Chemical Society. PMID 29211955 DOI: 10.1021/Jacs.7B11207  0.399
2017 Cunden LS, Brophy MB, Rodriguez GE, Flaxman HA, Nolan EM. Biochemical and Functional Evaluation of the Intramolecular Disulfide Bonds in the Zinc-Chelating Antimicrobial Protein Human S100A7 (Psoriasin). Biochemistry. PMID 28976190 DOI: 10.1021/Acs.Biochem.7B00781  0.424
2017 Johnstone TC, Nolan EM. Determination of the Molecular Structures of Ferric Enterobactin and Ferric Enantioenterobactin using Racemic Crystallography. Journal of the American Chemical Society. PMID 28956921 DOI: 10.1021/Jacs.7B09375  0.315
2017 Nakashige TG, Zygiel EM, Drennan CL, Nolan EM. Nickel Sequestration by the Host-Defense Protein Human Calprotectin. Journal of the American Chemical Society. PMID 28573847 DOI: 10.1021/Jacs.7B01212  0.407
2017 Nakashige TG, Nolan EM. Human calprotectin affects the redox speciation of iron. Metallomics : Integrated Biometal Science. PMID 28561859 DOI: 10.1039/C7Mt00044H  0.326
2017 Neumann W, Hadley RC, Nolan EM. Transition metals at the host-pathogen interface: how Neisseria exploit human metalloproteins for acquiring iron and zinc. Essays in Biochemistry. 61: 211-223. PMID 28487398 DOI: 10.1042/Ebc20160084  0.347
2017 Baker TM, Nakashige TG, Nolan EM, Neidig ML. Magnetic circular dichroism studies of iron(ii) binding to human calprotectin. Chemical Science. 8: 1369-1377. PMID 28451278 DOI: 10.1039/C6Sc03487J  0.377
2017 Chairatana P, Nolan EM. Human α-Defensin 6: A Small Peptide That Self-Assembles and Protects the Host by Entangling Microbes. Accounts of Chemical Research. PMID 28296382 DOI: 10.1021/Acs.Accounts.6B00653  0.339
2016 Chairatana P, Chiang IL, Nolan EM. Human α-defensin 6 self-assembly prevents adhesion and suppresses virulence traits of Candida albicans. Biochemistry. PMID 28026958 DOI: 10.1021/Acs.Biochem.6B01111  0.331
2016 Neumann W, Gulati A, Nolan EM. Metal homeostasis in infectious disease: recent advances in bacterial metallophores and the human metal-withholding response. Current Opinion in Chemical Biology. 37: 10-18. PMID 27992799 DOI: 10.1016/J.Cbpa.2016.09.012  0.336
2016 Shabab M, Arnold MF, Penterman J, Wommack AJ, Bocker HT, Price PA, Griffitts JS, Nolan EM, Walker GC. Disulfide cross-linking influences symbiotic activities of nodule peptide NCR247. Proceedings of the National Academy of Sciences of the United States of America. PMID 27551097 DOI: 10.1073/Pnas.1610724113  0.382
2016 Nakashige TG, Stephan JR, Cunden LS, Brophy MB, Wommack AJ, Keegan BC, Shearer JM, Nolan EM. The Hexahistidine Motif of Host-Defense Protein Human Calprotectin Contributes to Zinc Withholding and Its Functional Versatility. Journal of the American Chemical Society. PMID 27541598 DOI: 10.1021/Jacs.6B06845  0.436
2016 González LJ, Bahr G, Nakashige TG, Nolan EM, Bonomo RA, Vila AJ. Membrane anchoring stabilizes and favors secretion of New Delhi metallo-β-lactamase. Nature Chemical Biology. PMID 27182662 DOI: 10.1038/Nchembio.2083  0.321
2016 Chairatana P, Chu H, Castillo PA, Shen B, Bevins CL, Nolan EM. Proteolysis Triggers Self-Assembly and Unmasks Innate Immune Function of a Human α-Defensin Peptide. Chemical Science (Royal Society of Chemistry : 2010). 7: 1738-1752. PMID 27076903 DOI: 10.1039/C5Sc04194E  0.333
2016 Stephan JR, Nolan EM. Calcium-induced Tetramerization and Zinc Chelation Shield Human Calprotectin from Degradation by Host and Bacterial Extracellular Proteases. Chemical Science (Royal Society of Chemistry : 2010). 7: 1962-1975. PMID 26925211 DOI: 10.1039/C5Sc03287C  0.412
2016 Cunden LS, Gaillard A, Nolan EM. Calcium Ions Tune the Zinc-Sequestering Properties and Antimicrobial Activity of Human S100A12. Chemical Science (Royal Society of Chemistry : 2010). 7: 1338-1348. PMID 26913170 DOI: 10.1039/C5Sc03655K  0.414
2015 Chairatana P, Zheng T, Nolan EM. Targeting virulence: salmochelin modification tunes the antibacterial activity spectrum of β-lactams for pathogen-selective killing of Escherichia coli. Chemical Science. 6: 4458-4471. PMID 28717471 DOI: 10.1039/C5Sc00962F  0.343
2015 Nakashige TG, Zhang B, Krebs C, Nolan EM. Human calprotectin is an iron-sequestering host-defense protein. Nature Chemical Biology. 11: 765-71. PMID 26302479 DOI: 10.1038/Nchembio.1891  0.352
2015 Madsen JL, Johnstone TC, Nolan EM. Chemical Synthesis of Staphyloferrin B Affords Insight into the Molecular Structure, Iron Chelation, and Biological Activity of a Polycarboxylate Siderophore Deployed by the Human Pathogen Staphylococcus aureus. Journal of the American Chemical Society. PMID 26030732 DOI: 10.1021/Jacs.5B04557  0.316
2015 Chileveru HR, Lim SA, Chairatana P, Wommack AJ, Chiang IL, Nolan EM. Visualizing attack of Escherichia coli by the antimicrobial peptide human defensin 5. Biochemistry. 54: 1767-77. PMID 25664683 DOI: 10.1021/Bi501483Q  0.394
2015 Gagnon DM, Brophy MB, Bowman SE, Stich TA, Drennan CL, Britt RD, Nolan EM. Manganese binding properties of human calprotectin under conditions of high and low calcium: X-ray crystallographic and advanced electron paramagnetic resonance spectroscopic analysis. Journal of the American Chemical Society. 137: 3004-16. PMID 25597447 DOI: 10.1021/Ja512204S  0.372
2015 Brophy MB, Nolan EM. Manganese and microbial pathogenesis: sequestration by the Mammalian immune system and utilization by microorganisms. Acs Chemical Biology. 10: 641-51. PMID 25594606 DOI: 10.1021/Cb500792B  0.314
2014 Moser S, Chileveru HR, Tomaras J, Nolan EM. A bacterial mutant library as a tool to study the attack of a defensin peptide. Chembiochem : a European Journal of Chemical Biology. 15: 2684-8. PMID 25430675 DOI: 10.1002/Cbic.201402354  0.337
2014 Wommack AJ, Ziarek JJ, Tomaras J, Chileveru HR, Zhang Y, Wagner G, Nolan EM. Discovery and characterization of a disulfide-locked C(2)-symmetric defensin peptide. Journal of the American Chemical Society. 136: 13494-7. PMID 25181039 DOI: 10.1021/Ja505957W  0.416
2014 Chairatana P, Nolan EM. Molecular basis for self-assembly of a human host-defense peptide that entraps bacterial pathogens. Journal of the American Chemical Society. 136: 13267-76. PMID 25158166 DOI: 10.1021/Ja5057906  0.314
2014 Zheng T, Nolan EM. Enterobactin-mediated delivery of β-lactam antibiotics enhances antibacterial activity against pathogenic Escherichia coli. Journal of the American Chemical Society. 136: 9677-91. PMID 24927110 DOI: 10.1021/Ja503911P  0.317
2013 Brophy MB, Nakashige TG, Gaillard A, Nolan EM. Contributions of the S100A9 C-terminal tail to high-affinity Mn(II) chelation by the host-defense protein human calprotectin. Journal of the American Chemical Society. 135: 17804-17. PMID 24245608 DOI: 10.1021/Ja407147D  0.41
2013 Zhang Y, Cougnon FB, Wanniarachchi YA, Hayden JA, Nolan EM. Reduction of human defensin 5 affords a high-affinity zinc-chelating peptide. Acs Chemical Biology. 8: 1907-11. PMID 23841778 DOI: 10.1021/Cb400340K  0.77
2013 Hayden JA, Brophy MB, Cunden LS, Nolan EM. High-affinity manganese coordination by human calprotectin is calcium-dependent and requires the histidine-rich site formed at the dimer interface. Journal of the American Chemical Society. 135: 775-87. PMID 23276281 DOI: 10.1021/Ja3096416  0.387
2012 Wommack AJ, Robson SA, Wanniarachchi YA, Wan A, Turner CJ, Wagner G, Nolan EM. NMR solution structure and condition-dependent oligomerization of the antimicrobial peptide human defensin 5. Biochemistry. 51: 9624-37. PMID 23163963 DOI: 10.1021/Bi301255U  0.338
2012 Zheng T, Bullock JL, Nolan EM. Siderophore-mediated cargo delivery to the cytoplasm of Escherichia coli and Pseudomonas aeruginosa: syntheses of monofunctionalized enterobactin scaffolds and evaluation of enterobactin-cargo conjugate uptake. Journal of the American Chemical Society. 134: 18388-400. PMID 23098193 DOI: 10.1021/Ja3077268  0.302
2012 Brophy MB, Hayden JA, Nolan EM. Calcium ion gradients modulate the zinc affinity and antibacterial activity of human calprotectin. Journal of the American Chemical Society. 134: 18089-100. PMID 23082970 DOI: 10.1021/Ja307974E  0.376
2012 Zheng T, Nolan EM. Siderophore-based detection of Fe(III) and microbial pathogens. Metallomics : Integrated Biometal Science. 4: 866-80. PMID 22854844 DOI: 10.1039/C2Mt20082A  0.347
2011 Wanniarachchi YA, Kaczmarek P, Wan A, Nolan EM. Human defensin 5 disulfide array mutants: disulfide bond deletion attenuates antibacterial activity against Staphylococcus aureus. Biochemistry. 50: 8005-17. PMID 21861459 DOI: 10.1021/Bi201043J  0.366
2009 Strieker M, Nolan EM, Walsh CT, Marahiel MA. Stereospecific synthesis of threo- and erythro-beta-hydroxyglutamic acid during kutzneride biosynthesis. Journal of the American Chemical Society. 131: 13523-30. PMID 19722489 DOI: 10.1021/Ja9054417  0.421
2009 Altmann KH, Buchner J, Kessler H, Diederich F, Kräutler B, Lippard S, Liskamp R, Müller K, Nolan EM, Samori B, Schneider G, Schreiber SL, Schwalbe H, Toniolo C, van Boeckel CA, et al. The state of the art of chemical biology. Chembiochem : a European Journal of Chemical Biology. 10: 16-29. PMID 19115274 DOI: 10.1002/cbic.200800758  0.401
2009 Nolan EM, Walsh CT. How nature morphs peptide scaffolds into antibiotics. Chembiochem : a European Journal of Chemical Biology. 10: 34-53. PMID 19058272 DOI: 10.1002/Cbic.200800438  0.501
2009 Nolan EM, Lippard SJ. Small-molecule fluorescent sensors for investigating zinc metalloneurochemistry. Accounts of Chemical Research. 42: 193-203. PMID 18989940 DOI: 10.1021/Ar8001409  0.516
2008 Tomat E, Nolan EM, Jaworski J, Lippard SJ. Organelle-specific zinc detection using zinpyr-labeled fusion proteins in live cells. Journal of the American Chemical Society. 130: 15776-7. PMID 18973293 DOI: 10.1021/Ja806634E  0.662
2008 Nolan EM, Walsh CT. Investigations of the MceIJ-catalyzed posttranslational modification of the microcin E492 C-terminus: linkage of ribosomal and nonribosomal peptides to form "trojan horse" antibiotics. Biochemistry. 47: 9289-99. PMID 18690711 DOI: 10.1021/Bi800826J  0.548
2008 Nolan EM, Lippard SJ. Tools and tactics for the optical detection of mercuric ion. Chemical Reviews. 108: 3443-80. PMID 18652512 DOI: 10.1021/Cr068000Q  0.367
2008 Walsh CT, Nolan EM. Morphing peptide backbones into heterocycles. Proceedings of the National Academy of Sciences of the United States of America. 105: 5655-6. PMID 18398003 DOI: 10.1073/Pnas.0802300105  0.498
2008 Roush RF, Nolan EM, Löhr F, Walsh CT. Maturation of an Escherichia coli ribosomal peptide antibiotic by ATP-consuming N-P bond formation in microcin C7. Journal of the American Chemical Society. 130: 3603-9. PMID 18290647 DOI: 10.1021/Ja7101949  0.725
2008 Roush RF, Nolan EM, Löhr F, Walsh CT. Maturation of an Escherichia coli ribosomal peptide antibiotic by ATP-consuming N-P bond formation in microcin C7 (Journal of the American Chemical Society (2008) 130, (3603-3609)) Journal of the American Chemical Society. 130: 6055. DOI: 10.1021/ja802086j  0.727
2007 Nolan EM, Fischbach MA, Koglin A, Walsh CT. Biosynthetic tailoring of microcin E492m: post-translational modification affords an antibacterial siderophore-peptide conjugate. Journal of the American Chemical Society. 129: 14336-47. PMID 17973380 DOI: 10.1021/Ja074650F  0.655
2007 Neidig ML, Brown CD, Light KM, Fujimori DG, Nolan EM, Price JC, Barr EW, Bollinger JM, Krebs C, Walsh CT, Solomon EI. CD and MCD of CytC3 and taurine dioxygenase: role of the facial triad in alpha-KG-dependent oxygenases. Journal of the American Chemical Society. 129: 14224-31. PMID 17967013 DOI: 10.1021/Ja074557R  0.714
2007 Nolan EM, Lippard SJ. Turn-on and ratiometric mercury sensing in water with a red-emitting probe. Journal of the American Chemical Society. 129: 5910-8. PMID 17429971 DOI: 10.1021/Ja068879R  0.498
2006 Nolan EM, Ryu JW, Jaworski J, Feazell RP, Sheng M, Lippard SJ. Zinspy sensors with enhanced dynamic range for imaging neuronal cell zinc uptake and mobilization. Journal of the American Chemical Society. 128: 15517-28. PMID 17132019 DOI: 10.1021/Ja065759A  0.511
2006 Nolan EM, Jaworski J, Racine ME, Sheng M, Lippard SJ. Midrange affinity fluorescent Zn(II) sensors of the Zinpyr family: syntheses, characterization, and biological imaging applications. Inorganic Chemistry. 45: 9748-57. PMID 17112271 DOI: 10.1021/Ic061137E  0.486
2006 Nolan EM, Racine ME, Lippard SJ. Selective Hg(II) detection in aqueous solution with thiol derivatized fluoresceins. Inorganic Chemistry. 45: 2742-9. PMID 16529499 DOI: 10.1021/Ic052083W  0.499
2005 Nolan EM, Jaworski J, Okamoto K, Hayashi Y, Sheng M, Lippard SJ. QZ1 and QZ2: rapid, reversible quinoline-derivatized fluoresceins for sensing biological Zn(II). Journal of the American Chemical Society. 127: 16812-23. PMID 16316228 DOI: 10.1021/Ja052184T  0.512
2005 Nolan EM, Lippard SJ. MS4, a seminaphthofluorescein-based chemosensor for the ratiometric detection of Hg(II) Journal of Materials Chemistry. 15: 2778-2783. DOI: 10.1039/B501615K  0.482
2004 Nolan EM, Lippard SJ. The zinspy family of fluorescent zinc sensors: syntheses and spectroscopic investigations. Inorganic Chemistry. 43: 8310-7. PMID 15606177 DOI: 10.1021/Ic048778Z  0.48
2004 Chang CJ, Nolan EM, Jaworski J, Okamoto K, Hayashi Y, Sheng M, Lippard SJ. ZP8, a neuronal zinc sensor with improved dynamic range; imaging zinc in hippocampal slices with two-photon microscopy. Inorganic Chemistry. 43: 6774-9. PMID 15476377 DOI: 10.1021/Ic049293D  0.549
2004 Chang CJ, Nolan EM, Jaworski J, Burdette SC, Sheng M, Lippard SJ. Bright fluorescent chemosensor platforms for imaging endogenous pools of neuronal zinc. Chemistry & Biology. 11: 203-10. PMID 15123282 DOI: 10.1016/J.Chembiol.2004.01.017  0.541
2004 Nolan EM, Burdette SC, Harvey JH, Hilderbrand SA, Lippard SJ. Synthesis and characterization of zinc sensors based on a monosubstituted fluorescein platform. Inorganic Chemistry. 43: 2624-35. PMID 15074981 DOI: 10.1021/Ic035158+  0.459
2004 Chang CJ, Jaworski J, Nolan EM, Sheng M, Lippard SJ. A tautomeric zinc sensor for ratiometric fluorescence imaging: application to nitric oxide-induced release of intracellular zinc. Proceedings of the National Academy of Sciences of the United States of America. 101: 1129-34. PMID 14734801 DOI: 10.1073/Pnas.0308079100  0.572
2003 Nolan EM, Lippard SJ. A "turn-on" fluorescent sensor for the selective detection of mercuric ion in aqueous media. Journal of the American Chemical Society. 125: 14270-1. PMID 14624563 DOI: 10.1021/Ja037995G  0.486
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