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Felicia A. Etzkorn, Ph.D. - Publications

Affiliations: 
1993-2000 Chemistry University of Virginia, Charlottesville, VA 
 2000- Chemistry Virginia Polytechnic Institute and State University, Blacksburg, VA, United States 
Area:
protein structure and enzyme inhibitors by designing and synthesizing conformationally constrained mimics of peptides
Website:
http://www.etzkornlab.chem.vt.edu/
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34 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Mayfield JE, Fan S, Wei S, Zhang M, Li B, Ellington AD, Etzkorn FA, Zhang YJ. Chemical Tools To Decipher Regulation of Phosphatases by Proline Isomerization on Eukaryotic RNA Polymerase II. Acs Chemical Biology. PMID 26332362 DOI: 10.1021/Acschembio.5B00296  0.339
2015 Etzkorn FA, Zhao S. Stereospecific phosphorylation by the central mitotic kinase Cdk1-cyclin B. Acs Chemical Biology. 10: 952-6. PMID 25603287 DOI: 10.1021/Cb500815B  0.527
2013 Mercedes-Camacho AY, Mullins AB, Mason MD, Xu GG, Mahoney BJ, Wang X, Peng JW, Etzkorn FA. Kinetic isotope effects support the twisted amide mechanism of Pin1 peptidyl-prolyl isomerase. Biochemistry. 52: 7707-13. PMID 24116866 DOI: 10.1021/Bi400700B  0.351
2013 Nachman RJ, Wang XJ, Etzkorn FA, Kaczmarek K, Zabrocki J, Lopez J, Coast GM. Evaluation of insect CAP2b analogs with either an (E)-alkene, trans- or a (Z)-alkene, cis-Pro isostere identifies the Pro orientation for antidiuretic activity in the stink bug. Peptides. 41: 101-6. PMID 23036324 DOI: 10.1016/J.Peptides.2012.09.026  0.385
2012 Xu GG, Slebodnick C, Etzkorn FA. Cyclohexyl ketone inhibitors of Pin1 dock in a trans-diaxial cyclohexane conformation. Plos One. 7: e44226. PMID 23028504 DOI: 10.1371/Journal.Pone.0044226  0.393
2012 Zhang M, Wang XJ, Chen X, Bowman ME, Luo Y, Noel JP, Ellington AD, Etzkorn FA, Zhang Y. Structural and kinetic analysis of prolyl-isomerization/phosphorylation cross-talk in the CTD code. Acs Chemical Biology. 7: 1462-70. PMID 22670809 DOI: 10.1021/Cb3000887  0.385
2012 Tarrant MK, Rho HS, Xie Z, Jiang YL, Gross C, Culhane JC, Yan G, Qian J, Ichikawa Y, Matsuoka T, Zachara N, Etzkorn FA, Hart GW, Jeong JS, Blackshaw S, et al. Regulation of CK2 by phosphorylation and O-GlcNAcylation revealed by semisynthesis. Nature Chemical Biology. 8: 262-9. PMID 22267120 DOI: 10.1038/Nchembio.771  0.455
2011 Xu GG, Zhang Y, Mercedes-Camacho AY, Etzkorn FA. A reduced-amide inhibitor of Pin1 binds in a conformation resembling a twisted-amide transition state. Biochemistry. 50: 9545-50. PMID 21980916 DOI: 10.1021/Bi201055C  0.399
2011 Namanja AT, Wang XJ, Xu B, Mercedes-Camacho AY, Wilson KA, Etzkorn FA, Peng JW. Stereospecific gating of functional motions in Pin1. Proceedings of the National Academy of Sciences of the United States of America. 108: 12289-94. PMID 21746900 DOI: 10.1073/Pnas.1019382108  0.415
2010 Namanja AT, Wang XJ, Xu B, Mercedes-Camacho AY, Wilson BD, Wilson KA, Etzkorn FA, Peng JW. Toward flexibility-activity relationships by NMR spectroscopy: dynamics of Pin1 ligands. Journal of the American Chemical Society. 132: 5607-9. PMID 20356313 DOI: 10.1021/Ja9096779  0.308
2010 Mercedes-Camacho AY, Etzkorn FA. Enzyme-linked enzyme-binding assay for Pin1 WW domain ligands. Analytical Biochemistry. 402: 77-82. PMID 20230769 DOI: 10.1016/J.Ab.2010.03.018  0.34
2010 Etzkorn FA, Travins JM, Hart SA. ChemInform Abstract: Rare Protein Turns: γ-Turn, Helix-Turn-Helix, and cis-Proline Mimics Cheminform. 31: no-no. DOI: 10.1002/chin.200015250  0.583
2009 Xu GG, Etzkorn FA. Pin1 as an anticancer drug target. Drug News & Perspectives. 22: 399-407. PMID 19890497 DOI: 10.1358/Dnp.2009.22.7.1381751  0.338
2009 Dai N, Etzkorn FA. Cis-trans proline isomerization effects on collagen triple-helix stability are limited. Journal of the American Chemical Society. 131: 13728-32. PMID 19725497 DOI: 10.1021/Ja904177K  0.559
2009 Nachman RJ, Wang XJ, Etzkorn FA, Aziz OB, Davidovitch M, Kaczmarek K, Zabrocki J, Strey A, Pryor N, Altstein M. Evaluation of a PK/PBAN analog with an (E)-alkene, trans-Pro isostere identifies the Pro orientation for activity in four diverse PK/PBAN bioassays. Peptides. 30: 1254-9. PMID 19416747 DOI: 10.1016/J.Peptides.2009.04.017  0.365
2009 Nachman RJ, Kim YJ, Wang XJ, Etzkorn FA, Kaczmarek K, Zabrocki J, Adams ME. Potent activity of a PK/PBAN analog with an (E)-alkene, trans-Pro mimic identifies the Pro orientation and core conformation during interaction with HevPBANR-C receptor. Bioorganic & Medicinal Chemistry. 17: 4216-20. PMID 19356938 DOI: 10.1016/J.Bmc.2009.03.036  0.339
2008 Dai N, Wang XJ, Etzkorn FA. The effect of a trans-locked Gly-Pro alkene isostere on collagen triple helix stability. Journal of the American Chemical Society. 130: 5396-7. PMID 18366169 DOI: 10.1021/Ja711021M  0.528
2007 Zhao S, Etzkorn FA. A phosphorylated prodrug for the inhibition of Pin1. Bioorganic & Medicinal Chemistry Letters. 17: 6615-8. PMID 17935986 DOI: 10.1016/J.Bmcl.2007.09.073  0.475
2006 Wang XJ, Etzkorn FA. Peptidyl-prolyl isomerase inhibitors. Biopolymers. 84: 125-46. PMID 16302169 DOI: 10.1002/Bip.20240  0.363
2004 Wang XJ, Xu B, Mullins AB, Neiler FK, Etzkorn FA. Conformationally locked isostere of phosphoSer-cis-Pro inhibits Pin1 23-fold better than phosphoSer-trans-Pro isostere. Journal of the American Chemical Society. 126: 15533-42. PMID 15563182 DOI: 10.1021/Ja046396M  0.419
2003 Kapustin GV, Fejér G, Gronlund JL, McCafferty DG, Seto E, Etzkorn FA. Phosphorus-based SAHA analogues as histone deacetylase inhibitors. Organic Letters. 5: 3053-6. PMID 12916979 DOI: 10.1021/Ol035056N  0.595
2003 Wang XJ, Hart SA, Xu B, Mason MD, Goodell JR, Etzkorn FA. Serine-cis-proline and serine-trans-proline isosteres: stereoselective synthesis of (Z)- and (E)-alkene mimics by Still-Wittig and Ireland-Claisen rearrangements. The Journal of Organic Chemistry. 68: 2343-9. PMID 12636401 DOI: 10.1021/Jo026663B  0.648
2001 Hart SA, Trindle CO, Etzkorn FA. Solvent-dependent stereoselectivity in a Still-Wittig rearrangement: an experimental and ab initio study. Organic Letters. 3: 1789-91. PMID 11405712 DOI: 10.1021/Ol015764D  0.584
1999 Hart SA, Etzkorn FA. Cyclophilin Inhibition by a (Z)-Alkene cis-Proline Mimic. The Journal of Organic Chemistry. 64: 2998-2999. PMID 11674392 DOI: 10.1021/Jo990409A  0.612
1998 Hart SA, Sabat M, Etzkorn FA. Enantio- And Regioselective Synthesis of a (Z)-Alkene czs-Proline Mimic Journal of Organic Chemistry. 63: 7580-7581. DOI: 10.1021/Jo981387F  0.581
1997 Travins JM, Etzkorn FA. Design and Enantioselective Synthesis of a Peptidomimetic of the Turn in the Helix-Turn-Helix DNA-Binding Protein Motif. The Journal of Organic Chemistry. 62: 8387-8393. PMID 11671976 DOI: 10.1021/Jo971077H  0.359
1994 Fejzo J, Etzkorn FA, Clubb RT, Shi Y, Walsh CT, Wagner G. The mutant Escherichia coli F112W cyclophilin binds cyclosporin A in nearly identical conformation as human cyclophilin. Biochemistry. 33: 5711-20. PMID 8180197 DOI: 10.1021/Bi00185A007  0.481
1994 Etzkorn FA, Chang ZY, Stolz LA, Walsh CT. Cyclophilin residues that affect noncompetitive inhibition of the protein serine phosphatase activity of calcineurin by the cyclophilin.cyclosporin A complex. Biochemistry. 33: 2380-8. PMID 8117697 DOI: 10.1021/Bi00175A005  0.512
1994 Ke H, Mayrose D, Belshaw PJ, Alberg DG, Schreiber SL, Chang ZY, Etzkorn FA, Ho S, Walsh CT. Crystal structures of cyclophilin A complexed with cyclosporin A and N-methyl-4-[(E)-2-butenyl]-4,4-dimethylthreonine cyclosporin A. Structure (London, England : 1993). 2: 33-44. PMID 8075981 DOI: 10.1016/S0969-2126(00)00006-X  0.675
1994 Etzkorn FA, Guo T, Lipton MA, Goldberg SD, Bartlett PA. Cyclic hexapeptides and chimeric peptides as mimics of tendamistat Journal of the American Chemical Society. 116: 10412-10425. DOI: 10.1021/Ja00102A008  0.607
1993 Benson TE, Marquardt JL, Marquardt AC, Etzkorn FA, Walsh CT. Overexpression, purification, and mechanistic study of UDP-N-acetylenolpyruvylglucosamine reductase. Biochemistry. 32: 2024-30. PMID 8448160 DOI: 10.1021/Bi00059A019  0.437
1993 Etzkorn FA, Stolz LA, Chang Z, Walsh CT. Role of the cyclosporin-A-cyclophilin complex, FK506-FK506-binding protein complex and calcineurin in the inhibition of T-cell signal transduction. Current opinion in structural biology 1993, 3:929-933 Current Opinion in Structural Biology. 3: 929-933. DOI: 10.1016/0959-440X(93)90158-H  0.464
1992 Zydowsky LD, Etzkorn FA, Chang HY, Ferguson SB, Stolz LA, Ho SI, Walsh CT. Active site mutants of human cyclophilin A separate peptidyl-prolyl isomerase activity from cyclosporin A binding and calcineurin inhibition. Protein Science : a Publication of the Protein Society. 1: 1092-9. PMID 1338979 DOI: 10.1002/Pro.5560010903  0.5
1980 Briggs RW, Etzkorn FA, Hinton JF. 205Tl nuclear magnetic resonance study of the thallium complex of lasalocid (X-537A) Journal of Magnetic Resonance (1969). 37: 523-528. DOI: 10.1016/0022-2364(80)90057-8  0.508
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