| Year |
Citation |
Score |
| 2023 |
Kovaleva VA, Pattinson DJ, Barton C, Chapin SR, Minervina AA, Richards KA, Sant AJ, Thomas PG, Pogorelyy MV, Meyer HV. copepodTCR: Identification of Antigen-Specific T Cell Receptors with combinatorial peptide pooling. Biorxiv : the Preprint Server For Biology. PMID 38077028 DOI: 10.1101/2023.11.28.569052 |
0.5 |
|
| 2023 |
Henson TR, Richards KA, Gandhapudi SK, Woodward JG, Sant AJ. R-DOTAP Cationic Lipid Nanoparticles Outperform Squalene-Based Adjuvant Systems in Elicitation of CD4 T Cells after Recombinant Influenza Hemagglutinin Vaccination. Viruses. 15. PMID 36851752 DOI: 10.3390/v15020538 |
0.454 |
|
| 2022 |
Nelson SA, Richards KA, Glover MA, Chaves FA, Crank MC, Graham BS, Kanekiyo M, Sant AJ. CD4 T cell epitope abundance in ferritin core potentiates responses to hemagglutinin nanoparticle vaccines. Npj Vaccines. 7: 124. PMID 36289232 DOI: 10.1038/s41541-022-00547-0 |
0.462 |
|
| 2022 |
Sant AJ, Stern LJ. Editorial overview: The life and times of peptide-MHC. Current Opinion in Immunology. 78: 102244. PMID 36182763 DOI: 10.1016/j.coi.2022.102244 |
0.345 |
|
| 2022 |
Rattan A, White CL, Nelson S, Eismann M, Padilla-Quirarte H, Glover MA, Dileepan T, Marathe BM, Govorkova EA, Webby RJ, Richards KA, Sant AJ. Development of a Mouse Model to Explore CD4 T Cell Specificity, Phenotype, and Recruitment to the Lung after Influenza B Infection. Pathogens (Basel, Switzerland). 11. PMID 35215193 DOI: 10.3390/pathogens11020251 |
0.52 |
|
| 2022 |
Moritzky SA, Richards KA, Glover MA, Krammer F, Chaves FA, Topham DJ, Branche A, Nayak JL, Sant AJ. The negative effect of pre-existing immunity on influenza vaccine responses transcends the impact of vaccine formulation type and vaccination history. The Journal of Infectious Diseases. PMID 35199825 DOI: 10.1093/infdis/jiac068 |
0.406 |
|
| 2022 |
Richards KA, Lavery C, Keller GLJ, Miller J, Baker BM, Sant AJ. A previously unappreciated polymorphism in the beta chain of I-A expressed in autoimmunity-prone SJL mice: Combined impact on antibody, CD4 T cell recognition and MHC class II dimer structural stability. Molecular Immunology. 143: 17-26. PMID 34995990 DOI: 10.1016/j.molimm.2021.12.022 |
0.526 |
|
| 2021 |
Mudd PA, Minervina AA, Pogorelyy MV, Turner JS, Kim W, Kalaidina E, Petersen J, Schmitz AJ, Lei T, Haile A, Kirk AM, Mettelman RC, Crawford JC, Nguyen THO, Rowntree LC, ... ... Sant AJ, et al. SARS-CoV-2 mRNA vaccination elicits a robust and persistent T follicular helper cell response in humans. Cell. PMID 35026152 DOI: 10.1016/j.cell.2021.12.026 |
0.433 |
|
| 2021 |
Nelson SA, Dileepan T, Rasley A, Jenkins MK, Fischer NO, Sant AJ. Intranasal nanoparticle vaccination elicits a persistent, polyfunctional CD4 T cell response in the murine lung specific for a highly conserved influenza antigen that are sufficient to mediate protection from influenza virus challenge. Journal of Virology. JVI0084121. PMID 34076479 DOI: 10.1128/JVI.00841-21 |
0.439 |
|
| 2021 |
Richards KA, Glover M, Crawford JC, Thomas P, White C, Sant AJ. Circulating CD4 T cells elicited by endemic coronaviruses display vast disparities in abundance and functional potential linked to both antigen specificity and age. The Journal of Infectious Diseases. PMID 33556959 DOI: 10.1093/infdis/jiab076 |
0.483 |
|
| 2020 |
Richards KA, Moritzky S, Shannon I, Fitzgerald T, Yang H, Branche A, Topham DJ, Treanor JJ, Nayak J, Sant AJ. Recombinant HA-based vaccine outperforms split and subunit vaccines in elicitation of influenza-specific CD4 T cells and CD4 T cell-dependent antibody responses in humans. Npj Vaccines. 5: 77. PMID 34433828 DOI: 10.1038/s41541-020-00227-x |
0.436 |
|
| 2020 |
Richards KA, Moritzky S, Shannon I, Fitzgerald T, Yang H, Branche A, Topham DJ, Treanor JJ, Nayak J, Sant AJ. Recombinant HA-based vaccine outperforms split and subunit vaccines in elicitation of influenza-specific CD4 T cells and CD4 T cell-dependent antibody responses in humans. Npj Vaccines. 5: 77. PMID 32884842 DOI: 10.1038/s41541-020-00227-x |
0.436 |
|
| 2019 |
Topham DJ, DeDiego ML, Nogales A, Sangster MY, Sant A. Immunity to Influenza Infection in Humans. Cold Spring Harbor Perspectives in Medicine. PMID 31871226 DOI: 10.1101/Cshperspect.A038729 |
0.342 |
|
| 2019 |
Knowlden ZAG, Richards KA, Moritzky SA, Sant AJ. Peptide Epitope Hot Spots of CD4 T Cell Recognition Within Influenza Hemagglutinin During the Primary Response to Infection. Pathogens (Basel, Switzerland). 8. PMID 31694141 DOI: 10.3390/Pathogens8040220 |
0.66 |
|
| 2019 |
Richards KA, Shannon I, Treanor JJ, Yang H, Nayak JL, Sant AJ. Evidence that blunted CD4 T cells responses underlie deficient protective antibody responses to influenza vaccines in repeatedly vaccinated human subjects. The Journal of Infectious Diseases. PMID 31504634 DOI: 10.1093/Infdis/Jiz433 |
0.502 |
|
| 2019 |
Henry C, Palm AE, Utset HA, Huang M, Ho IY, Zheng NY, Fitzgerald T, Neu KE, Chen YQ, Krammer F, Treanor JJ, Sant AJ, Topham DJ, Wilson PC. Monoclonal antibody responses after recombinant HA vaccine versus subunit inactivated influenza virus vaccine: a comparative study. Journal of Virology. PMID 31434733 DOI: 10.1128/Jvi.01150-19 |
0.369 |
|
| 2019 |
DiPiazza AT, Fan S, Rattan A, DeDiego ML, Chaves F, Neumann G, Kawaoka Y, Sant AJ. A Novel Vaccine Strategy to Overcome Poor Immunogenicity of Avian Influenza Vaccines through Mobilization of Memory CD4 T Cells Established by Seasonal Influenza. Journal of Immunology (Baltimore, Md. : 1950). PMID 31399519 DOI: 10.4049/Jimmunol.1900819 |
0.521 |
|
| 2019 |
Khurana S, Hahn M, Coyle EM, King LR, Lin TL, Treanor J, Sant A, Golding H. Repeat vaccination reduces antibody affinity maturation across different influenza vaccine platforms in humans. Nature Communications. 10: 3338. PMID 31350391 DOI: 10.1038/S41467-019-11296-5 |
0.328 |
|
| 2019 |
Rattan A, Richards KA, Knowlden ZAG, Sant AJ. Protein vaccination directs the CD4+ T cell response towards shared protective epitopes that can be recalled after influenza infection. Journal of Virology. PMID 31341045 DOI: 10.1128/Jvi.00947-19 |
0.536 |
|
| 2019 |
Nelson SA, Sant AJ. Imprinting and Editing of the Human CD4 T Cell Response to Influenza Virus. Frontiers in Immunology. 10: 932. PMID 31134060 DOI: 10.3389/Fimmu.2019.00932 |
0.537 |
|
| 2019 |
Sant AJ. The way forward: Potentiating protective immunity to novel and pandemic influenza through engagement of memory CD4 T cells. The Journal of Infectious Diseases. PMID 30715376 DOI: 10.1093/Infdis/Jiy666 |
0.55 |
|
| 2018 |
DiPiazza AT, Richards KA, Liu WC, Albrecht RA, Sant AJ. Analyses of Cellular Immune Responses in Ferrets Following Influenza Virus Infection. Methods in Molecular Biology (Clifton, N.J.). 1836: 513-530. PMID 30151589 DOI: 10.1007/978-1-4939-8678-1_24 |
0.557 |
|
| 2018 |
Sant AJ, DiPiazza AT, Nayak JL, Rattan A, Richards KA. CD4 T cells in protection from influenza virus: Viral antigen specificity and functional potential. Immunological Reviews. 284: 91-105. PMID 29944766 DOI: 10.1111/Imr.12662 |
0.607 |
|
| 2018 |
Richards KA, Treanor JJ, Nayak JL, Sant AJ. Overarching Immunodominance Patterns and Substantial Diversity in Specificity and Functionality in the Circulating Human Influenza A and B CD4 T Cell Repertoire. The Journal of Infectious Diseases. PMID 29762692 DOI: 10.1093/Infdis/Jiy288 |
0.543 |
|
| 2018 |
Richards KA, DiPiazza AT, Rattan A, Knowlden ZAG, Yang H, Sant AJ. Diverse Epitope Specificity, Immunodominance Hierarchy, and Functional Avidity of Effector CD4 T Cells Established During Priming Is Maintained in Lung After Influenza A Virus Infection. Frontiers in Immunology. 9: 655. PMID 29681900 DOI: 10.3389/Fimmu.2018.00655 |
0.549 |
|
| 2018 |
DiPiazza A, Laniewski N, Rattan A, Topham DJ, Miller J, Sant AJ. CD4 T cell epitope specificity and cytokine potential are preserved as cells transition from the lung vasculature to lung tissue following influenza infection. Journal of Virology. PMID 29669836 DOI: 10.1128/Jvi.00377-18 |
0.552 |
|
| 2018 |
Sant AJ, Richards KA, Nayak J. Distinct and complementary roles of CD4 T cells in protective immunity to influenza virus. Current Opinion in Immunology. 53: 13-21. PMID 29621639 DOI: 10.1016/J.Coi.2018.03.019 |
0.597 |
|
| 2017 |
Zost SJ, Parkhouse K, Gumina ME, Kim K, Diaz Perez S, Wilson PC, Treanor JJ, Sant AJ, Cobey S, Hensley SE. Contemporary H3N2 influenza viruses have a glycosylation site that alters binding of antibodies elicited by egg-adapted vaccine strains. Proceedings of the National Academy of Sciences of the United States of America. PMID 29109276 DOI: 10.1073/Pnas.1712377114 |
0.339 |
|
| 2017 |
DiPiazza A, Nogales A, Poulton N, Wilson PC, Martínez-Sobrido L, Sant AJ. Pandemic 2009 H1N1 Influenza Venus reporter virus reveals broad diversity of MHC class II-positive antigen-bearing cells following infection in vivo. Scientific Reports. 7: 10857. PMID 28883436 DOI: 10.1038/S41598-017-11313-X |
0.531 |
|
| 2017 |
Alam S, Chan C, Qiu X, Shannon I, White CL, Sant AJ, Nayak JL. Selective pre-priming of HA-specific CD4 T cells restores immunological reactivity to HA on heterosubtypic influenza infection. Plos One. 12: e0176407. PMID 28493882 DOI: 10.1371/Journal.Pone.0176407 |
0.587 |
|
| 2017 |
Gu XX, Plotkin SA, Edwards KM, Sette A, Mills KHG, Levy O, Sant AJ, Mo A, Alexander W, Lu KT, Taylor CE. Waning Immunity and Microbial Vaccines - Workshop of the National Institute of Allergy and Infectious Diseases. Clinical and Vaccine Immunology : Cvi. PMID 28490424 DOI: 10.1128/Cvi.00034-17 |
0.35 |
|
| 2017 |
DiPiazza A, Richards K, Poulton N, Sant AJ. Avian-derived and human, seasonal-derived hemagglutinin proteins elicit CD4 T cell responses that are comparable in epitope abundance and diversity. Clinical and Vaccine Immunology : Cvi. PMID 28100497 DOI: 10.1128/Cvi.00548-16 |
0.582 |
|
| 2017 |
Brewer MG, DiPiazza A, Acklin J, Feng C, Sant AJ, Dewhurst S. Nanoparticles decorated with viral antigens are more immunogenic at low surface density. Vaccine. PMID 28057386 DOI: 10.1016/J.Vaccine.2016.12.049 |
0.407 |
|
| 2016 |
Tesini BL, Wright TW, Malone JE, Haidaris CG, Harber M, Sant AJ, Nayak JL, Gigliotti F. Immunization with Pca1 protects mice against Pneumocystis pneumonia and generates antibody to Pneumocystis jirovecii. Infection and Immunity. PMID 28031260 DOI: 10.1128/Iai.00850-16 |
0.406 |
|
| 2016 |
DiPiazza A, Richards K, Batarse F, Lockard L, Zeng H, García-Sastre A, Albrecht RA, Sant AJ. Flow Cytometric and Cytokine ELISpot Approaches to Characterize the Cell-mediated Immune Response in Ferrets Following Influenza Virus Infection. Journal of Virology. PMID 27356897 DOI: 10.1128/Jvi.01001-16 |
0.552 |
|
| 2016 |
Knowlden ZA, Sant AJ. CD4 T cell epitope specificity determines follicular versus non-follicular helper differentiation in the polyclonal response to influenza infection or vaccination. Scientific Reports. 6: 28287. PMID 27329272 DOI: 10.1038/Srep28287 |
0.685 |
|
| 2016 |
DiPiazza A, Richards KA, Knowlden ZA, Nayak JL, Sant AJ. The Role of CD4 T Cell Memory in Generating Protective Immunity to Novel and Potentially Pandemic Strains of Influenza. Frontiers in Immunology. 7: 10. PMID 26834750 DOI: 10.3389/Fimmu.2016.00010 |
0.616 |
|
| 2015 |
Leddon SA, Richards KA, Treanor JJ, Sant AJ. Abundance and specificity of influenza reactive circulating memory Tfh and non-Tfh CD4 T cells in healthy adults. Immunology. PMID 26094691 DOI: 10.1111/Imm.12491 |
0.634 |
|
| 2015 |
Richards KA, Nayak J, Chaves FA, DiPiazza A, Knowlden ZA, Alam S, Treanor JJ, Sant AJ. Seasonal Influenza Can Poise Hosts for CD4 T-Cell Immunity to H7N9 Avian Influenza. The Journal of Infectious Diseases. 212: 86-94. PMID 25492919 DOI: 10.1093/Infdis/Jiu662 |
0.547 |
|
| 2015 |
Nayak JL, Richards KA, Yang H, Treanor JJ, Sant AJ. Effect of influenza A(H5N1) vaccine prepandemic priming on CD4+ T-cell responses. The Journal of Infectious Diseases. 211: 1408-17. PMID 25378637 DOI: 10.1093/Infdis/Jiu616 |
0.533 |
|
| 2014 |
Alam S, Knowlden ZA, Sangster MY, Sant AJ. CD4 T cell help is limiting and selective during the primary B cell response to influenza virus infection. Journal of Virology. 88: 314-24. PMID 24155379 DOI: 10.1128/Jvi.02077-13 |
0.569 |
|
| 2014 |
Nayak J, Sant A, Alam S. 1061The Role of CD4 T Cell Mediated Immunity in Pandemic Influenza Protection Open Forum Infectious Diseases. 1: S311-S311. DOI: 10.1093/Ofid/Ofu052.769 |
0.555 |
|
| 2013 |
Sant AJ, Chaves FA, Leddon SA, Tung J. The control of the specificity of CD4 T cell responses: thresholds, breakpoints, and ceilings. Frontiers in Immunology. 4: 340. PMID 24167504 DOI: 10.3389/Fimmu.2013.00340 |
0.703 |
|
| 2013 |
Weilhammer DR, Blanchette CD, Fischer NO, Alam S, Loots GG, Corzett M, Thomas C, Lychak C, Dunkle AD, Ruitenberg JJ, Ghanekar SA, Sant AJ, Rasley A. The use of nanolipoprotein particles to enhance the immunostimulatory properties of innate immune agonists against lethal influenza challenge. Biomaterials. 34: 10305-18. PMID 24075406 DOI: 10.1016/J.Biomaterials.2013.09.038 |
0.331 |
|
| 2013 |
Nayak JL, Alam S, Sant AJ. Cutting edge: Heterosubtypic influenza infection antagonizes elicitation of immunological reactivity to hemagglutinin. Journal of Immunology (Baltimore, Md. : 1950). 191: 1001-5. PMID 23794632 DOI: 10.4049/Jimmunol.1203520 |
0.561 |
|
| 2013 |
Tung J, Sant AJ. Orchestration of CD4 T cell epitope preferences after multipeptide immunization. Journal of Immunology (Baltimore, Md. : 1950). 191: 764-72. PMID 23772029 DOI: 10.4049/Jimmunol.1300312 |
0.655 |
|
| 2013 |
Nayak JL, Fitzgerald TF, Richards KA, Yang H, Treanor JJ, Sant AJ. CD4+ T-cell expansion predicts neutralizing antibody responses to monovalent, inactivated 2009 pandemic influenza A(H1N1) virus subtype H1N1 vaccine. The Journal of Infectious Diseases. 207: 297-305. PMID 23148285 DOI: 10.1093/Infdis/Jis684 |
0.504 |
|
| 2012 |
Engels B, Chervin AS, Sant AJ, Kranz DM, Schreiber H. Long-term Persistence of CD4(+) but Rapid Disappearance of CD8(+) T Cells Expressing an MHC Class I-restricted TCR of Nanomolar Affinity. Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 652-660. PMID 28160633 DOI: 10.1038/mt.2011.286 |
0.543 |
|
| 2012 |
Richards KA, Chaves FA, Alam S, Sant AJ. Trivalent inactivated influenza vaccines induce broad immunological reactivity to both internal virion components and influenza surface proteins. Vaccine. 31: 219-25. PMID 23099328 DOI: 10.1016/J.Vaccine.2012.10.039 |
0.612 |
|
| 2012 |
Leddon SA, Sant AJ. The peptide specificity of the endogenous T follicular helper cell repertoire generated after protein immunization. Plos One. 7: e46952. PMID 23077537 DOI: 10.1371/Journal.Pone.0046952 |
0.663 |
|
| 2012 |
Sant AJ, McMichael A. Revealing the role of CD4(+) T cells in viral immunity. The Journal of Experimental Medicine. 209: 1391-5. PMID 22851641 DOI: 10.1084/Jem.20121517 |
0.571 |
|
| 2012 |
Nayak JL, Sant AJ. Loss in CD4 T-cell responses to multiple epitopes in influenza due to expression of one additional MHC class II molecule in the host. Immunology. 136: 425-36. PMID 22747522 DOI: 10.1111/J.1365-2567.2012.03599.X |
0.695 |
|
| 2012 |
Chaves FA, Lee AH, Nayak JL, Richards KA, Sant AJ. The utility and limitations of current Web-available algorithms to predict peptides recognized by CD4 T cells in response to pathogen infection. Journal of Immunology (Baltimore, Md. : 1950). 188: 4235-48. PMID 22467652 DOI: 10.4049/Jimmunol.1103640 |
0.574 |
|
| 2012 |
Sundararajan A, Huan L, Richards KA, Marcelin G, Alam S, Joo H, Yang H, Webby RJ, Topham DJ, Sant AJ, Sangster MY. Host differences in influenza-specific CD4 T cell and B cell responses are modulated by viral strain and route of immunization. Plos One. 7: e34377. PMID 22457834 DOI: 10.1371/Journal.Pone.0034377 |
0.576 |
|
| 2012 |
Engels B, Chervin AS, Sant AJ, Kranz DM, Schreiber H. Long-term persistence of CD4(+) but rapid disappearance of CD8(+) T cells expressing an MHC class I-restricted TCR of nanomolar affinity. Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 652-60. PMID 22233579 DOI: 10.1038/Mt.2011.286 |
0.614 |
|
| 2011 |
Alam S, Sant AJ. Infection with seasonal influenza virus elicits CD4 T cells specific for genetically conserved epitopes that can be rapidly mobilized for protective immunity to pandemic H1N1 influenza virus. Journal of Virology. 85: 13310-21. PMID 21976658 DOI: 10.1128/Jvi.05728-11 |
0.521 |
|
| 2011 |
Richards KA, Chaves FA, Sant AJ. The memory phase of the CD4 T-cell response to influenza virus infection maintains its diverse antigen specificity. Immunology. 133: 246-56. PMID 21517839 DOI: 10.1111/J.1365-2567.2011.03435.X |
0.63 |
|
| 2011 |
Nayak JL, Sant AJ. T cell immunology for the clinician. The Pediatric Infectious Disease Journal. 30: 248-50. PMID 21317604 DOI: 10.1097/Inf.0B013E3182074658 |
0.467 |
|
| 2010 |
Richards KA, Topham D, Chaves FA, Sant AJ. Cutting edge: CD4 T cells generated from encounter with seasonal influenza viruses and vaccines have broad protein specificity and can directly recognize naturally generated epitopes derived from the live pandemic H1N1 virus. Journal of Immunology (Baltimore, Md. : 1950). 185: 4998-5002. PMID 20889549 DOI: 10.4049/Jimmunol.1001395 |
0.536 |
|
| 2010 |
Leddon SA, Sant AJ. Generation of MHC class II-peptide ligands for CD4 T-cell allorecognition of MHC class II molecules. Current Opinion in Organ Transplantation. 15: 505-11. PMID 20616724 DOI: 10.1097/Mot.0B013E32833Bfc5C |
0.568 |
|
| 2010 |
Nayak JL, Richards KA, Chaves FA, Sant AJ. Analyses of the specificity of CD4 T cells during the primary immune response to influenza virus reveals dramatic MHC-linked asymmetries in reactivity to individual viral proteins. Viral Immunology. 23: 169-80. PMID 20373997 DOI: 10.1089/Vim.2009.0099 |
0.655 |
|
| 2010 |
Desmet EA, Hollenbaugh JA, Sime PJ, Wright TW, Topham DJ, Sant AJ, Takimoto T, Dewhurst S, Maggirwar SB. Mixed Lineage Kinase 3 deficiency delays viral clearance in the lung and is associated with diminished influenza-induced cytopathic effect in infected cells. Virology. 400: 224-32. PMID 20185156 DOI: 10.1016/J.Virol.2010.02.001 |
0.317 |
|
| 2009 |
Weaver JM, Chaves FA, Sant AJ. Abortive activation of CD4 T cell responses during competitive priming in vivo. Proceedings of the National Academy of Sciences of the United States of America. 106: 8647-52. PMID 19423666 DOI: 10.1073/Pnas.0811584106 |
0.7 |
|
| 2009 |
Richards KA, Chaves FA, Sant AJ. Infection of HLA-DR1 transgenic mice with a human isolate of influenza a virus (H1N1) primes a diverse CD4 T-cell repertoire that includes CD4 T cells with heterosubtypic cross-reactivity to avian (H5N1) influenza virus. Journal of Virology. 83: 6566-77. PMID 19386707 DOI: 10.1128/Jvi.00302-09 |
0.526 |
|
| 2009 |
Weaver JM, Sant AJ. Understanding the focused CD4 T cell response to antigen and pathogenic organisms. Immunologic Research. 45: 123-43. PMID 19198764 DOI: 10.1007/S12026-009-8095-8 |
0.707 |
|
| 2008 |
Weaver JM, Lazarski CA, Richards KA, Chaves FA, Jenks SA, Menges PR, Sant AJ. Immunodominance of CD4 T cells to foreign antigens is peptide intrinsic and independent of molecular context: implications for vaccine design. Journal of Immunology (Baltimore, Md. : 1950). 181: 3039-48. PMID 18713974 DOI: 10.4049/Jimmunol.181.5.3039 |
0.766 |
|
| 2008 |
Huang S, Gilfillan S, Kim S, Thompson B, Wang X, Sant AJ, Fremont DH, Lantz O, Hansen TH. MR1 uses an endocytic pathway to activate mucosal-associated invariant T cells. The Journal of Experimental Medicine. 205: 1201-11. PMID 18443227 DOI: 10.1084/Jem.20072579 |
0.538 |
|
| 2008 |
Larkin J, Rankin AL, Picca CC, Riley MP, Jenks SA, Sant AJ, Caton AJ. CD4+CD25+ regulatory T cell repertoire formation shaped by differential presentation of peptides from a self-antigen. Journal of Immunology (Baltimore, Md. : 1950). 180: 2149-57. PMID 18250421 DOI: 10.4049/Jimmunol.180.4.2149 |
0.592 |
|
| 2008 |
Menges PR, Jenks SA, Bikoff EK, Friedmann DR, Knowlden ZA, Sant AJ. An MHC class II restriction bias in CD4 T cell responses toward I-A is altered to I-E in DM-deficient mice. Journal of Immunology (Baltimore, Md. : 1950). 180: 1619-33. PMID 18209058 DOI: 10.4049/Jimmunol.180.3.1619 |
0.771 |
|
| 2008 |
Bandyopadhyay A, Arneson L, Beeson C, Sant AJ. The relative energetic contributions of dominant P1 pocket versus hydrogen bonding interactions to peptide:class II stability: implications for the mechanism of DM function. Molecular Immunology. 45: 1248-57. PMID 17980431 DOI: 10.1016/J.Molimm.2007.09.011 |
0.476 |
|
| 2007 |
Chaves FA, Sant AJ. Measurement of peptide dissociation from MHC class II molecules. Current Protocols in Immunology / Edited by John E. Coligan ... [Et Al.]. Unit 18.14. PMID 18432989 DOI: 10.1002/0471142735.Im1814S77 |
0.519 |
|
| 2007 |
Gardiner A, Richards KA, Sant AJ, Arneson LS. Conformation of MHC class II I-A(g7) is sensitive to the P9 anchor amino acid in bound peptide. International Immunology. 19: 1103-13. PMID 17855434 DOI: 10.1093/Intimm/Dxm081 |
0.49 |
|
| 2007 |
Sant AJ, Chaves FA, Krafcik FR, Lazarski CA, Menges P, Richards K, Weaver JM. Immunodominance in CD4 T-cell responses: implications for immune responses to influenza virus and for vaccine design. Expert Review of Vaccines. 6: 357-68. PMID 17542751 DOI: 10.1586/14760584.6.3.357 |
0.761 |
|
| 2007 |
Richards KA, Chaves FA, Krafcik FR, Topham DJ, Lazarski CA, Sant AJ. Direct ex vivo analyses of HLA-DR1 transgenic mice reveal an exceptionally broad pattern of immunodominance in the primary HLA-DR1-restricted CD4 T-cell response to influenza virus hemagglutinin. Journal of Virology. 81: 7608-19. PMID 17507491 DOI: 10.1128/Jvi.02834-06 |
0.666 |
|
| 2007 |
Huang S, Sant A, Hansen T. MR1, a Class Ib Molecule, Utilizes a MHC Class II Like Pathway to Activate Mucosal Associated Invariant T Cells Journal of Allergy and Clinical Immunology. 119: S90. DOI: 10.1016/J.Jaci.2006.11.381 |
0.385 |
|
| 2006 |
Chaves FA, Richards KA, Torelli A, Wedekind J, Sant AJ. Peptide-binding motifs for the I-Ad MHC class II molecule: Alternate pH-dependent binding behavior Biochemistry. 45: 6426-6433. PMID 16700553 DOI: 10.1021/Bi060194G |
0.584 |
|
| 2006 |
Lazarski CA, Chaves FA, Sant AJ. The impact of DM on MHC class II-restricted antigen presentation can be altered by manipulation of MHC-peptide kinetic stability. The Journal of Experimental Medicine. 203: 1319-28. PMID 16682499 DOI: 10.1084/Jem.20060058 |
0.593 |
|
| 2006 |
Drake JR, Sant AJ. The Mechanics of Class II Processing: Establishment of a Peptide Class II Hierarchy Immunodominance: the Choice of the Immune System. 31-55. DOI: 10.1002/3527608028.ch2 |
0.358 |
|
| 2005 |
Sant AJ, Chaves FA, Jenks SA, Richards KA, Menges P, Weaver JM, Lazarski CA. The relationship between immunodominance, DM editing, and the kinetic stability of MHC class II:peptide complexes. Immunological Reviews. 207: 261-78. PMID 16181342 DOI: 10.1111/J.0105-2896.2005.00307.X |
0.779 |
|
| 2005 |
Lazarski CA, Chaves FA, Jenks SA, Wu S, Richards KA, Weaver JM, Sant AJ. The kinetic stability of MHC class II:peptide complexes is a key parameter that dictates immunodominance. Immunity. 23: 29-40. PMID 16039577 DOI: 10.1016/J.Immuni.2005.05.009 |
0.667 |
|
| 2005 |
McFarland BJ, Katz JF, Sant AJ, Beeson C. Energetics and cooperativity of the hydrogen bonding and anchor interactions that bind peptides to MHC class II protein. Journal of Molecular Biology. 350: 170-83. PMID 15921691 DOI: 10.1016/J.Jmb.2005.04.069 |
0.454 |
|
| 2005 |
Chaves FA, Hou P, Wu S, Sant AJ. Replacement of the membrane proximal region of I-A(d) MHC class II molecule with I-E-derived sequences promotes production of an active and stable soluble heterodimer without altering peptide-binding specificity. Journal of Immunological Methods. 300: 74-92. PMID 15896797 DOI: 10.1016/J.Jim.2005.02.013 |
0.44 |
|
| 2001 |
Arneson LS, Katz JF, Liu M, Sant AJ. Hydrogen bond integrity between MHC class II molecules and bound peptide determines the intracellular fate of MHC class II molecules Journal of Immunology. 167: 6939-6946. PMID 11739513 DOI: 10.4049/Jimmunol.167.12.6939 |
0.492 |
|
| 2001 |
McFarland BJ, Katz JF, Beeson C, Sant AJ. Energetic asymmetry among hydrogen bonds in MHC class II*peptide complexes. Proceedings of the National Academy of Sciences of the United States of America. 98: 9231-6. PMID 11470892 DOI: 10.1073/Pnas.151131498 |
0.488 |
|
| 2000 |
Nanda NK, Sant AJ. DM determines the cryptic and immunodominant fate of T cell epitopes Journal of Experimental Medicine. 192: 781-788. PMID 10993909 DOI: 10.1084/Jem.192.6.781 |
0.581 |
|
| 2000 |
Arneson LS, Peterson M, Sant AJ. The MHC class II molecule I-A(g7) exists in alternate conformations that are peptide dependent Journal of Immunology. 165: 2059-2067. PMID 10925290 DOI: 10.4049/Jimmunol.165.4.2059 |
0.486 |
|
| 1999 |
Sant AJ, Beeson C, McFarland B, Cao J, Ceman S, Bryant PW, Wu S. Individual hydrogen bonds play a critical role in MHC class II:peptide interactions: Implications for the dynamic aspects of class II trafficking and DM-mediated peptide exchange Immunological Reviews. 172: 239-253. PMID 10631950 DOI: 10.1111/J.1600-065X.1999.Tb01369.X |
0.491 |
|
| 1999 |
McFarland BJ, Sant AJ, Lybrand TP, Beeson C. Ovalbumin(323-339) peptide binds to the major histocompatibility complex class II I-A(d) protein using two functionally distinct registers. Biochemistry. 38: 16663-70. PMID 10600129 DOI: 10.1021/Bi991393L |
0.548 |
|
| 1999 |
Bryant PW, Roos P, Ploegh HL, Sant AJ. Deviant trafficking of I-A(d) mutant molecules is reflected in their peptide binding properties European Journal of Immunology. 29: 2729-2739. PMID 10508247 DOI: 10.1002/(Sici)1521-4141(199909)29:09<2729::Aid-Immu2729>3.0.Co;2-A |
0.472 |
|
| 1998 |
Ceman S, Wu S, Jardetzky TS, Sant AJ. Alteration of a single hydrogen bond between class II molecules and peptide results in rapid degradation of class ii molecules after invariant chain removal Journal of Experimental Medicine. 188: 2139-2149. PMID 9841927 DOI: 10.1084/Jem.188.11.2139 |
0.487 |
|
| 1997 |
Tan LJ, Ceman S, Chervonsky A, Rodriguez-Paris J, Steck TL, Sant AJ. Late events in the intracellular sorting of major histocompatibility complex class II molecules are regulated by the 80-82 segment of the class II beta chain. European Journal of Immunology. 27: 1479-88. PMID 9209501 DOI: 10.1002/Eji.1830270626 |
0.395 |
|
| 1996 |
Katz JF, Stebbins C, Appella E, Sant AJ. Invariant chain and DM edit self-peptide presentation by major histocompatibility complex (MHC) class II molecules Journal of Experimental Medicine. 184: 1747-1753. PMID 8920863 DOI: 10.1084/Jem.184.5.1747 |
0.565 |
|
| 1995 |
Ceman S, Sant AJ. The function of invariant chain in class II-restricted antigen presentation Seminars in Immunology. 7: 373-387. PMID 8775463 DOI: 10.1006/Smim.1995.0042 |
0.514 |
|
| 1995 |
Stebbins CC, Loss GE, Elias CG, Chervonsky A, Sant AJ. The requirement for DM in class II-restricted antigen presentation and SDS-stable dimer formation is allele and species dependent Journal of Experimental Medicine. 181: 223-234. PMID 7807005 DOI: 10.1084/Jem.181.1.223 |
0.468 |
|
| 1995 |
Chervonsky A, Sant AJ. In the absence of major histocompatibility complex class II molecules, invariant chain is translocated to late endocytic compartments by autophagy European Journal of Immunology. 25: 911-918. PMID 7737293 DOI: 10.1002/Eji.1830250408 |
0.38 |
|
| 1995 |
Miller* J, Sant† AJ. Introduction: MHC class II-restricted antigen presentation Seminars in Immunology. 7: 343-346. DOI: 10.1006/Smim.1995.0038 |
0.445 |
|
| 1994 |
Sant AJ, Miller J. MHC class II antigen processing: biology of invariant chain Current Opinion in Immunology. 6: 57-63. PMID 8172680 DOI: 10.1016/0952-7915(94)90034-5 |
0.43 |
|
| 1994 |
Chervonsky AV, Gordon L, Sant AJ. A segment of the MHC class II β chain plays a critical role in targeting class II molecules to the endocytic pathway International Immunology. 6: 973-982. PMID 7947465 DOI: 10.1093/Intimm/6.7.973 |
0.403 |
|
| 1994 |
Sant AJ. Endogenous antigen presentation by MHC class II molecules Immunologic Research. 13: 253-267. PMID 7616053 DOI: 10.1007/Bf02935617 |
0.597 |
|
| 1993 |
Loss GE, Elias CG, Fields PE, Ribaudo RK, McKisic M, Sant AJ. Major histocompatibility complex class II-restricted presentation of an internally synthesized antigen displays cell-type variability and segregates from the exogenous class II and endogenous class I presentation pathways. The Journal of Experimental Medicine. 178: 73-85. PMID 8315396 DOI: 10.1084/Jem.178.1.73 |
0.503 |
|
| 1991 |
Sant AJ, Hendrix LR, Coligan JE, Maloy WL, Germain RN. Defective intracellular transport as a common mechanism limiting expression of inappropriately paired class II major histocompatibility complex alpha/beta chains. The Journal of Experimental Medicine. 174: 799-808. PMID 1919435 DOI: 10.1084/Jem.174.4.799 |
0.37 |
|
| 1989 |
Sant AJ, Germain RN. Intracellular competition for component chains determines class II MHC cell surface phenotype. Cell. 57: 797-805. PMID 2497991 DOI: 10.1016/0092-8674(89)90794-0 |
0.308 |
|
| 1986 |
Giacoletto KS, Sant AJ, Bono C, Gorka J, O'Sullivan DM, Quaranta V, Schwartz BD. The human invariant chain is the core protein of the human class II-associated proteoglycan. The Journal of Experimental Medicine. 164: 1422-39. PMID 3464690 DOI: 10.1084/Jem.164.5.1422 |
0.427 |
|
| 1985 |
Sant AJ, Cullen SE, Giacoletto KS, Schwartz BD. Invariant chain is the core protein of the Ia-associated chondroitin sulfate proteoglycan. The Journal of Experimental Medicine. 162: 1916-34. PMID 3864916 DOI: 10.1084/Jem.162.6.1916 |
0.362 |
|
| 1984 |
Sant AJ, Cullen SE, Schwartz BD. Identification of a sulfate-bearing molecule associated with HLA class II antigens. Proceedings of the National Academy of Sciences of the United States of America. 81: 1534-8. PMID 6424118 DOI: 10.1073/Pnas.81.5.1534 |
0.399 |
|
| 1983 |
Sant AJ, Schwartz BD, Cullen SE. Identification of a new component in the murine Ia molecular complex. The Journal of Experimental Medicine. 158: 1979-92. PMID 6580373 DOI: 10.1084/Jem.158.6.1979 |
0.353 |
|
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