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Lieping Chen - Publications

Affiliations: 
Johns Hopkins University, Baltimore, MD 
Area:
Immunology, Cell Biology
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353 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Kim TK, Han X, Hu Q, Vandsemb EN, Fielder CM, Hong J, Kim KW, Mason EF, Plowman RS, Wang J, Wang Q, Zhang JP, Badri T, Sanmamed MF, Zheng L, ... ... Chen L, et al. PD-1H/VISTA mediates immune evasion in acute myeloid leukemia. The Journal of Clinical Investigation. PMID 38060328 DOI: 10.1172/JCI164325  0.317
2023 Vesely MD, Kidacki M, Gaule P, Gupta S, Nyein Chan NN, Han X, Yeung JT, Chen L. Immune inhibitory molecule PD-1H (VISTA) colocalizes with CD11b myeloid cells in melanoma and is associated with poor outcomes. The Journal of Investigative Dermatology. PMID 37562584 DOI: 10.1016/j.jid.2023.07.008  0.366
2023 Wang Q, He J, Flies DB, Luo L, Chen L. Author Correction: Programmed death one homolog maintains the pool size of regulatory T cells by promoting their differentiation and stability. Scientific Reports. 13: 11603. PMID 37463928 DOI: 10.1038/s41598-023-37791-w  0.641
2022 Zheng L, Han X, Yao S, Zhu Y, Klement J, Wu S, Ji L, Zhu G, Cheng X, Tobiasova Z, Yu W, Huang B, Vesely MD, Wang J, Zhang J, ... ... Chen L, et al. The CD8α-PILRα interaction maintains CD8 T cell quiescence. Science (New York, N.Y.). 376: 996-1001. PMID 35617401 DOI: 10.1126/science.aaz8658  0.379
2021 Hu L, Chen L, Xiao Z, Zheng X, Chen Y, Xian N, Cho C, Luo L, Huang G, Chen L. Ablation of T cell-associated PD-1H enhances functionality and promotes adoptive immunotherapy. Jci Insight. PMID 34905507 DOI: 10.1172/jci.insight.148247  0.411
2021 Sun Y, Chen W, Torphy RJ, Yao S, Zhu G, Lin R, Lugano R, Miller EN, Fujiwara Y, Bian L, Zheng L, Anand S, Gao F, Zhang W, Ferrara SE, ... ... Chen L, et al. Blockade of the CD93 pathway normalizes tumor vasculature to facilitate drug delivery and immunotherapy. Science Translational Medicine. 13. PMID 34321321 DOI: 10.1126/scitranslmed.abc8922  0.689
2021 Sanmamed MF, Nie X, Desai SS, Villaroel-Espindola F, Badri T, Zhao D, Kim AW, Ji L, Zhang T, Quinlan E, Cheng X, Han X, Vesely MD, Nassar AF, Sun J, ... ... Chen L, et al. A burned-out CD8+ T-cell subset expands in the tumor microenvironment and curbs cancer immunotherapy. Cancer Discovery. PMID 33658301 DOI: 10.1158/2159-8290.CD-20-0962  0.378
2021 Li Y, Cong Y, Jia M, He Q, Zhong H, Zhao Y, Li H, Yan M, You J, Liu J, Chen L, Hang H, Wang S. Targeting IL-21 to tumor-reactive T cells enhances memory T cell responses and anti-PD-1 antibody therapy. Nature Communications. 12: 951. PMID 33574265 DOI: 10.1038/s41467-021-21241-0  0.362
2021 Yeung J, Yaghoobi V, Aung TN, Vesely MD, Zhang T, Gaule P, Gunel M, Rimm DL, Chen L. Spatially Resolved and Quantitative Analysis of the Immunological Landscape in Human Meningiomas. Journal of Neuropathology and Experimental Neurology. PMID 33393633 DOI: 10.1093/jnen/nlaa152  0.348
2020 Vesely MD, Chen L. Normalization Cancer Immunotherapy for Melanoma. The Journal of Investigative Dermatology. PMID 32092349 DOI: 10.1016/J.Jid.2020.02.005  0.339
2020 Huang B, Luo L, Wang J, He B, Feng R, Xian N, Zhang Q, Chen L, Huang G. B7-H3 specific T cells with chimeric antigen receptor and decoy PD-1 receptors eradicate established solid human tumors in mouse models. Oncoimmunology. 9: 1684127. PMID 32002297 DOI: 10.1080/2162402X.2019.1684127  0.442
2020 Slater BT, Han X, Chen L, Xiong Y. Structural insight into T cell coinhibition by PD-1H (VISTA). Proceedings of the National Academy of Sciences of the United States of America. PMID 31919279 DOI: 10.2210/Pdb6U6V/Pdb  0.436
2020 Ding A, Villarroel-Espindola F, Ducler A, Henick BS, Desai S, Gianino N, Zugazagoitia J, Rimm DL, Robert A, Cruzalegui F, Ferré P, Herbst R, Sanmamed M, Chen L, Schalper KA. Abstract 5525: VISTA/PSGL1 axis as a dominant immunomodulatory pathway in human non-small cell lung cancer Immunology. 80: 5525-5525. DOI: 10.1158/1538-7445.Am2020-5525  0.393
2019 Han X, Vesely MD, Yang W, Sanmamed MF, Badri T, Alawa J, López-Giráldez F, Gaule P, Lee SW, Zhang JP, Nie X, Nassar A, Boto A, Flies DB, Zheng L, ... ... Chen L, et al. PD-1H (VISTA)-mediated suppression of autoimmunity in systemic and cutaneous lupus erythematosus. Science Translational Medicine. 11. PMID 31826980 DOI: 10.1126/Scitranslmed.Aax1159  0.72
2019 Chen Y, Wang J, Wang X, Li X, Song J, Fang J, Liu X, Liu T, Wang D, Li Q, Wen S, Ma D, Xia J, Luo L, Zheng SG, ... ... Chen L, et al. Pik3ip1 Is a Negative Immune Regulator that Inhibits Antitumor T cell Immunity. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 31350312 DOI: 10.1158/1078-0432.Ccr-18-4134  0.506
2019 Hu Q, Ye Y, Chan LC, Li Y, Liang K, Lin A, Egranov SD, Zhang Y, Xia W, Gong J, Pan Y, Chatterjee SS, Yao J, Evans KW, Nguyen TK, ... ... Chen L, et al. Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression. Nature Immunology. PMID 31160797 DOI: 10.1038/S41590-019-0400-7  0.403
2019 Zheng X, Xiao ZX, Hu L, Fang X, Luo L, Chen L. Dendritic cell-associated B7-H3 suppresses the production of autoantibodies and renal inflammation in a mouse model of systemic lupus erythematosus. Cell Death & Disease. 10: 393. PMID 31113935 DOI: 10.1038/S41419-019-1623-0  0.438
2019 Datar IJ, Sanmamed MF, Wang J, Henick BS, Choi J, Badri T, Dong W, Mani N, Toki MI, Mejías L, Lozano MD, Perez-Gracia JL, Velcheti V, Hellmann MD, Gainor JF, ... ... Chen L, et al. Expression analysis and significance of PD-1, LAG-3 and TIM-3 in human non-small cell lung cancer using spatially-resolved and multiparametric single-cell analysis. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 31053602 DOI: 10.1158/1078-0432.Ccr-18-4142  0.364
2019 Wang J, Sun J, Liu LN, Flies DB, Nie X, Toki M, Zhang J, Song C, Zarr M, Zhou X, Han X, Archer KA, O'Neill T, Herbst RS, Boto AN, ... ... Chen L, et al. Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy. Nature Medicine. PMID 30833750 DOI: 10.1038/S41591-019-0374-X  0.765
2019 Doroshow DB, Sanmamed MF, Hastings K, Politi K, Rimm DL, Chen L, Melero I, Schalper KA, Herbst RS. Immunotherapy in Non-Small Cell Lung Cancer: Facts and Hopes. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 30824587 DOI: 10.1158/1078-0432.Ccr-18-1538  0.357
2019 David P, Megger DA, Kaiser T, Werner T, Liu J, Chen L, Sitek B, Dittmer U, Zelinskyy G. The PD-1/PD-L1 Pathway Affects the Expansion and Function of Cytotoxic CD8 T Cells During an Acute Retroviral Infection. Frontiers in Immunology. 10: 54. PMID 30804928 DOI: 10.3389/Fimmu.2019.00054  0.417
2019 Lee JW, Zhang Y, Eoh KJ, Sharma R, Sanmamed MF, Wu J, Choi J, Park HS, Iwasaki A, Kaftan E, Chen L, Papadimitrakopoulou V, Herbst RS, Koo JS. The Combination of MEK inhibitor with Immunomodulatory Antibodies Targeting PD-1 and PD-L1 Results in Prolonged Survival in Kras/p53-Driven Lung Cancer. Journal of Thoracic Oncology : Official Publication of the International Association For the Study of Lung Cancer. PMID 30771521 DOI: 10.1016/J.Jtho.2019.02.004  0.385
2019 Tian Y, Sun Y, Gao F, Koenig MR, Sunderland A, Fujiwara Y, Torphy RJ, Chen L, Edil BH, Schulick RD, Zhu Y. CD28H expression identifies resident memory CD8 + T cells with less cytotoxicity in human peripheral tissues and cancers. Oncoimmunology. 8: e1538440. PMID 30713797 DOI: 10.1080/2162402X.2018.1538440  0.483
2019 Toki M, Zugazagoitia J, Altan M, Liu L, Mani N, Liu Y, Syrigos K, Chen L, Langermann S, Herbst R, Rimm D. Abstract 3151: Quantitative measurement of Siglec-15 expression in non-small cell lung cancer and its association with PD-L1, B7-H4 and tumor infiltrating lymphocytes Cancer Research. 79: 3151-3151. DOI: 10.1158/1538-7445.Am2019-3151  0.459
2019 Lam W, Yang X, Jiang Z, han X, Guan F, Hu R, Xu C, Cai W, Cheng W, Liu S, Cai Y, Rattray N, Johnson C, Chen L, Cheng Y. Abstract 2252: YIV-906 (PHY906) enhanced the anti-tumor activity of immune checkpoint blockade therapy (Anti-PD1) against liver cancer by changing the tumor micro-environment associated with M1 macrophages infiltration Cancer Research. 79: 2252-2252. DOI: 10.1158/1538-7445.Am2019-2252  0.383
2019 Vesely M, Gaule P, Chen L. 843 Immune checkpoint molecule PD-1H/VISTA expression correlates with melanoma survival Journal of Investigative Dermatology. 139: S145. DOI: 10.1016/J.Jid.2019.03.919  0.372
2018 Wang J, Sanmamed MF, Datar I, Su TT, Ji L, Sun J, Chen L, Chen Y, Zhu G, Yin W, Zheng L, Zhou T, Badri T, Yao S, Zhu S, ... ... Chen L, et al. Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of LAG-3. Cell. PMID 30580966 DOI: 10.1016/J.Cell.2018.11.010  0.466
2018 Yu W, Chen L, Guo S, Luo L, Chen L. B7-H1 agonists could prevent disseminated inflammation by desensitizing cell susceptibility to cytotoxic T-cells. Oncoimmunology. 7: e1504156. PMID 30574431 DOI: 10.1080/2162402X.2018.1504156  0.528
2018 Chen Y, Ma D, Wang X, Fang J, Liu X, Song J, Li X, Ren X, Li Q, Li Q, Wen S, Luo L, Xia J, Cui J, Zeng G, ... Chen L, et al. Calnexin impairs the antitumor immunity of CD4+ and CD8+ T cells. Cancer Immunology Research. PMID 30401678 DOI: 10.1158/2326-6066.Cir-18-0124  0.519
2018 Sanmamed MF, Chen L. A Paradigm Shift in Cancer Immunotherapy: From Enhancement to Normalization. Cell. 175: 313-326. PMID 30290139 DOI: 10.1016/J.Cell.2018.09.035  0.405
2018 Gettinger SN, Choi J, Mani N, Sanmamed MF, Datar I, Sowell R, Du VY, Kaftan E, Goldberg S, Dong W, Zelterman D, Politi K, Kavathas P, Kaech S, Yu X, ... ... Chen L, et al. A dormant TIL phenotype defines non-small cell lung carcinomas sensitive to immune checkpoint blockers. Nature Communications. 9: 3196. PMID 30097571 DOI: 10.1038/S41467-018-05032-8  0.492
2018 Podojil JR, Chiang MY, Ifergan I, Copeland R, Liu LN, Maloveste S, Langermann S, Liebenson D, Balabanov R, Chi H, Chen L, Vignali DAA, Miller SD. B7-H4 Modulates Regulatory CD4 T Cell Induction and Function via Ligation of a Semaphorin 3a/Plexin A4/Neuropilin-1 Complex. Journal of Immunology (Baltimore, Md. : 1950). PMID 29898965 DOI: 10.4049/Jimmunol.1700811  0.54
2018 Kim TK, Herbst RS, Chen L. Defining and Understanding Adaptive Resistance in Cancer Immunotherapy. Trends in Immunology. PMID 29802087 DOI: 10.1016/J.It.2018.05.001  0.374
2018 Zhang J, Song K, Wang J, Li Y, Liu S, Dai C, Chen L, Wang S, Qin Z. S100A4 blockage alleviates agonistic anti-CD137 antibody-induced liver pathology without disruption of antitumor immunity. Oncoimmunology. 7: e1296996. PMID 29632708 DOI: 10.1080/2162402X.2017.1296996  0.421
2018 Chen L, Azuma T, Yu W, Zheng X, Luo L, Chen L. B7-H1 maintains the polyclonal T cell response by protecting dendritic cells from cytotoxic T lymphocyte destruction. Proceedings of the National Academy of Sciences of the United States of America. PMID 29507197 DOI: 10.1073/Pnas.1722043115  0.489
2018 Lu N, Li Y, Zhang Z, Xing J, Sun Y, Yao S, Chen L. Human Semaphorin-4A drives Th2 responses by binding to receptor ILT-4. Nature Communications. 9: 742. PMID 29467366 DOI: 10.1038/S41467-018-03128-9  0.413
2018 Xiao Q, Wu J, Wang WJ, Chen S, Zheng Y, Yu X, Meeth K, Sahraei M, Bothwell ALM, Chen L, Bosenberg M, Chen J, Sexl V, Sun L, Li L, et al. DKK2 imparts tumor immunity evasion through β-catenin-independent suppression of cytotoxic immune-cell activation. Nature Medicine. PMID 29431745 DOI: 10.1038/Nm.4496  0.455
2018 Henick BS, Datar I, Villarroel-Espindola F, Sanmamed MF, Yu J, Tuktamyshov R, Li AC, Toki M, Syrigos KN, Rimm DL, Chen L, Herbst RS, Schalper KA. Multiplexed analysis of myeloid cell (MC) markers to characterize the innate immune composition and clinical features of human non-small cell lung carcinomas (NSCLC). Journal of Clinical Oncology. 36: 12002-12002. DOI: 10.1200/Jco.2018.36.15_Suppl.12002  0.341
2018 Lam W, Yang X, Jiang Z, Han X, Guan F, Cheng W, Liu S, Chen L, Cheng Y. Abstract 2724: YIV906 (PHY906) enhanced the antitumor activity of immune checkpoint blockade therapy: Anti-PD1 against liver cancer Cancer Research. 78: 2724-2724. DOI: 10.1158/1538-7445.Am2018-2724  0.375
2018 Morgado M, Datar I, Wang J, Sanmamed MF, McEachern K, Jenkins D, Chen L, Carvajal-Hausdorf D, Rimm DL, Herbst RS, Schalper KA. Abstract 1681: Simultaneous measurement and significance of PD-1, LAG-3 and TIM-3 expression in human solid tumors Cancer Research. 78: 1681-1681. DOI: 10.1158/1538-7445.Am2018-1681  0.437
2017 Villarroel-Espindola F, Yu X, Datar I, Mani N, Sanmamed MF, Velcheti V, Syrigos KN, Toki MI, Zhao H, Chen L, Herbst RS, Schalper KA. Spatially resolved and quantitative analysis of VISTA/PD-1H as a novel immunotherapy target in human non-small cell lung cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 29203588 DOI: 10.1158/1078-0432.Ccr-17-2542  0.351
2017 Jacquelot N, Roberti MP, Enot DP, Rusakiewicz S, Ternès N, Jegou S, Woods DM, Sodré AL, Hansen M, Meirow Y, Sade-Feldman M, Burra A, Kwek SS, Flament C, Messaoudene M, ... ... Chen L, et al. Predictors of responses to immune checkpoint blockade in advanced melanoma. Nature Communications. 8: 592. PMID 28928380 DOI: 10.1038/S41467-017-00608-2  0.443
2017 Drabczyk-Pluta M, Werner T, Hoffmann D, Leng Q, Chen L, Dittmer U, Zelinskyy G. Granulocytic myeloid-derived suppressor cells suppress virus-specific CD8(+) T cell responses during acute Friend retrovirus infection. Retrovirology. 14: 42. PMID 28835242 DOI: 10.1186/S12977-017-0364-3  0.458
2017 Wang Q, He J, Flies DB, Luo L, Chen L. Programmed death one homolog maintains the pool size of regulatory T cells by promoting their differentiation and stability. Scientific Reports. 7: 6086. PMID 28729608 DOI: 10.1038/S41598-017-06410-W  0.745
2017 Nie X, Chen W, Zhu Y, Huang B, Yu W, Wu Z, Guo S, Zhu Y, Luo L, Wang S, Chen L. B7-DC (PD-L2) costimulation of CD4(+) T-helper 1 response via RGMb. Cellular & Molecular Immunology. PMID 28479601 DOI: 10.1038/Cmi.2017.17  0.486
2017 Liu H, Li X, Hu L, Zhu M, He B, Luo L, Chen L. A crucial role of the PD-1H coinhibitory receptor in suppressing experimental asthma. Cellular & Molecular Immunology. PMID 28479600 DOI: 10.1038/Cmi.2017.16  0.42
2017 Kluger HM, Zito CR, Turcu G, Baine M, Zhang H, Adeniran A, Sznol M, Rimm DL, Kluger Y, Chen L, Cohen JV, Jilaveanu LB. PD-L1 Studies Across Tumor Types, its Differential Expression and Predictive Value in Patients Treated with Immune Checkpoint Inhibitors. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 28223273 DOI: 10.1158/1078-0432.Ccr-16-3146  0.363
2017 Lam W, jiang Z, han X, Liu S, Chen L, Cheng Y. Abstract 5584: PHY906(YIV-906), an adjuvant based on a 1800-year-old Chinese medicine, enhanced the anti-tumor activity of Immune checkpoint blockade therapy: anti-PDL1, anti-PD1, anti-PD1/CTLA4 against melanoma Cancer Research. 77: 5584-5584. DOI: 10.1158/1538-7445.Am2017-5584  0.366
2017 Hirano T, Honda T, Tamada K, Chen L, Kabashima K. 317 PD-L1 on radio-resistant cells regulates effector CD8+ T-cell activation during the elicitation phase of contact hypersensitivity Journal of Investigative Dermatology. 137. DOI: 10.1016/J.Jid.2017.07.512  0.433
2017 Hirano T, Honda T, Tamada K, Chen L, Kabashima K. 030 Regulatory mechanisms of PD-1/PD-L1 pathway on CD8+ T cell activation in murine contact hypersensitivity Journal of Investigative Dermatology. 137. DOI: 10.1016/J.Jid.2017.02.043  0.406
2017 Hirano T, Honda T, Tamada K, Chen L, Kabashima K. Essential role of PD-1/PD-L1 pathway to regulate CD8+ T-cell activation in murine contact hypersensitivity Journal of Dermatological Science. 86. DOI: 10.1016/J.Jdermsci.2017.02.188  0.407
2016 Zhang Y, Chen L. Classification of Advanced Human Cancers Based on Tumor Immunity in the MicroEnvironment (TIME) for Cancer Immunotherapy. Jama Oncology. PMID 27490017 DOI: 10.1001/Jamaoncol.2016.2450  0.32
2016 Schalper KA, Carvajal-Hausdorf D, McLaughlin J, Altan M, Velcheti V, Gaule P, Sanmamed MF, Chen L, Herbst RS, Rimm DL. Differential expression and significance of PD-L1, IDO-1 and B7-H4 in human lung cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 27440266 DOI: 10.1158/1078-0432.Ccr-16-0150  0.374
2016 Zhu Y, Yao S, Augustine MM, Xu H, Wang J, Sun J, Broadwater M, Ruff W, Luo L, Zhu G, Tamada K, Chen L. Neuron-specific SALM5 limits inflammation in the CNS via its interaction with HVEM. Science Advances. 2: e1500637. PMID 27152329 DOI: 10.1126/Sciadv.1500637  0.322
2016 Zou W, Wolchok JD, Chen L. PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations. Science Translational Medicine. 8: 328rv4. PMID 26936508 DOI: 10.1126/Scitranslmed.Aad7118  0.366
2016 Sun H, Luo L, Lal B, Ma X, Chen L, Hann CL, Fulton AM, Leahy DJ, Laterra J, Li M. A monoclonal antibody against KCNK9 K(+) channel extracellular domain inhibits tumour growth and metastasis. Nature Communications. 7: 10339. PMID 26842342 DOI: 10.1038/Ncomms10339  0.353
2016 Jacquelot N, Roberti MP, Enot DP, Rusakiewicz S, Semeraro M, Jégou S, Flores C, Chen L, Kwon BS, Borg C, Weide B, Aubin F, Dalle S, Kohrt H, Ayyoub M, et al. Immunophenotyping of stage III melanoma reveals parameters associated with patient prognosis. The Journal of Investigative Dermatology. PMID 26829031 DOI: 10.1016/J.Jid.2015.12.042  0.406
2015 Akhmetzyanova I, Drabczyk M, Neff CP, Gibbert K, Dietze KK, Werner T, Liu J, Chen L, Lang KS, Palmer BE, Dittmer U, Zelinskyy G. Correction: PD-L1 Expression on Retrovirus-Infected Cells Mediates Immune Escape from CD8+ T Cell Killing. Plos Pathogens. 11: e1005364. PMID 26684741 DOI: 10.1371/Journal.Ppat.1005364  0.428
2015 Park HJ, Park JS, Jeong YH, Son J, Ban YH, Lee BH, Chen L, Chang J, Chung DH, Choi I, Ha SJ. Correction: PD-1 Upregulated on Regulatory T Cells during Chronic Virus Infection Enhances the Suppression of CD8+ T Cell Immune Response via the Interaction with PD-L1 Expressed on CD8+ T Cells. Journal of Immunology (Baltimore, Md. : 1950). 195: 5841-2. PMID 26637664 DOI: 10.4049/jimmunol.1502256  0.379
2015 Akhmetzyanova I, Drabczyk M, Neff CP, Gibbert K, Dietze KK, Werner T, Liu J, Chen L, Lang KS, Palmer BE, Dittmer U, Zelinskyy G. PD-L1 Expression on Retrovirus-Infected Cells Mediates Immune Escape from CD8+ T Cell Killing. Plos Pathogens. 11: e1005224. PMID 26484769 DOI: 10.1371/Journal.Ppat.1005224  0.419
2015 Chen L, Han X. Anti-PD-1/PD-L1 therapy of human cancer: past, present, and future. The Journal of Clinical Investigation. 125: 3384-91. PMID 26325035 DOI: 10.1172/Jci80011  0.367
2015 Baine MK, Turcu G, Zito CR, Adeniran AJ, Camp RL, Chen L, Kluger HM, Jilaveanu LB. Characterization of tumor infiltrating lymphocytes in paired primary and metastatic renal cell carcinoma specimens. Oncotarget. 6: 24990-5002. PMID 26317902 DOI: 10.18632/Oncotarget.4572  0.431
2015 Apetoh L, Smyth MJ, Drake CG, Abastado JP, Apte RN, Ayyoub M, Blay JY, Bonneville M, Butterfield LH, Caignard A, Castelli C, Cavallo F, Celis E, Chen L, Colombo MP, et al. Consensus nomenclature for CD8(+) T cell phenotypes in cancer. Oncoimmunology. 4: e998538. PMID 26137416 DOI: 10.1080/2162402X.2014.998538  0.472
2015 Luo L, Zhu G, Xu H, Yao S, Zhou G, Zhu Y, Tamada K, Huang L, Flies AD, Broadwater M, Ruff W, van Deursen JM, Melero I, Zhu Z, Chen L. B7-H3 Promotes Pathogenesis of Autoimmune Disease and Inflammation by Regulating the Activity of Different T Cell Subsets. Plos One. 10: e0130126. PMID 26065426 DOI: 10.1371/Journal.Pone.0130126  0.466
2015 Weigelin B, Bolaños E, Teijeira A, Martinez-Forero I, Labiano S, Azpilikueta A, Morales-Kastresana A, Quetglas JI, Wagena E, Sánchez-Paulete AR, Chen L, Friedl P, Melero I. Focusing and sustaining the antitumor CTL effector killer response by agonist anti-CD137 mAb. Proceedings of the National Academy of Sciences of the United States of America. 112: 7551-6. PMID 26034288 DOI: 10.1073/pnas.1506357112  0.49
2015 Park HJ, Park JS, Jeong YH, Son J, Ban YH, Lee BH, Chen L, Chang J, Chung DH, Choi I, Ha SJ. PD-1 Upregulated on Regulatory T Cells during Chronic Virus Infection Enhances the Suppression of CD8+ T Cell Immune Response via the Interaction with PD-L1 Expressed on CD8+ T Cells. Journal of Immunology (Baltimore, Md. : 1950). 194: 5801-11. PMID 25934860 DOI: 10.4049/Jimmunol.1401936  0.476
2015 Flies DB, Higuchi T, Chen L. Mechanistic Assessment of PD-1H Coinhibitory Receptor-Induced T Cell Tolerance to Allogeneic Antigens. Journal of Immunology (Baltimore, Md. : 1950). 194: 5294-304. PMID 25917101 DOI: 10.4049/Jimmunol.1402648  0.746
2015 Kluger HM, Zito CR, Barr ML, Baine MK, Chiang VL, Sznol M, Rimm DL, Chen L, Jilaveanu LB. Characterization of PD-L1 Expression and Associated T-cell Infiltrates in Metastatic Melanoma Samples from Variable Anatomic Sites. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 25788491 DOI: 10.1158/1078-0432.Ccr-14-3073  0.406
2015 McKay JT, Egan RP, Yammani RD, Chen L, Shin T, Yagita H, Haas KM. PD-1 suppresses protective immunity to Streptococcus pneumoniae through a B cell-intrinsic mechanism. Journal of Immunology (Baltimore, Md. : 1950). 194: 2289-99. PMID 25624454 DOI: 10.4049/Jimmunol.1401673  0.411
2015 Deng R, Cassady K, Li X, Yao S, Zhang M, Racine J, Lin J, Chen L, Zeng D. B7H1/CD80 interaction augments PD-1-dependent T cell apoptosis and ameliorates graft-versus-host disease. Journal of Immunology (Baltimore, Md. : 1950). 194: 560-74. PMID 25488990 DOI: 10.4049/Jimmunol.1402157  0.465
2015 Tongu M, Harashima N, Tamada K, Chen L, Harada M. Intermittent chemotherapy can retain the therapeutic potential of anti-CD137 antibody during the late tumor-bearing state. Cancer Science. 106: 9-17. PMID 25363339 DOI: 10.1111/Cas.12568  0.425
2015 Owonikoko TK, Kowalski J, Kim S, Dwivedi B, Chen Z, Behera M, Mayfield W, Hermann RC, Chen L, Khuri FR, Ramalingam SS, Sica G. PD-L1, PD-1, and CTLA-4 as prognostic biomarkers in resected non-small cell lung cancer. Journal of Clinical Oncology. 33: 7551-7551. DOI: 10.1200/Jco.2015.33.15_Suppl.7551  0.316
2015 Schalper KA, Carvajal-Hausdorf D, McLaughlin J, Velcheti V, Chen L, Sanmamed M, Herbst RS, Rimm DL. Clinical significance of PD-L1 protein expression on tumor-associated macrophages in lung cancer Journal For Immunotherapy of Cancer. 3: 415. DOI: 10.1186/2051-1426-3-S2-P415  0.372
2015 Chen L, Goswami S, Yi X, Byers L, Diao L, Roybal J, Ungewiss C, Peng D, Wang J, Wistuba I, Chen L, Ullrich S, Heymach J, Kurie J, Qin X, et al. Abstract B67: A big role in tumor immune microenvironment of a small non-coding RNA: microRNA-200 Cancer Immunology Research. 3. DOI: 10.1158/2326-6074.Tumimm14-B67  0.443
2015 Sun H, Luo L, Lal B, Ma X, Chen L, Fulton A, Leahy D, Laterra J, Li M. ATPS-82PROBING THE TUMORIGENIC PROPERTIES OF TWO PORE POTASSIUM CHANNELS USING INHIBITORY KCNK9 mAbs Neuro-Oncology. 17: v36.3-v36. DOI: 10.1093/Neuonc/Nov204.82  0.37
2014 Byers JT, Paniccia A, Kaplan J, Koenig M, Kahn N, Wilson L, Chen L, Schulick RD, Edil BH, Zhu Y. Expression of the Novel Costimulatory Molecule B7-H5 in Pancreatic Cancer. Annals of Surgical Oncology. PMID 25519928 DOI: 10.1245/S10434-014-4293-2  0.359
2014 Chen L, Gibbons DL, Goswami S, Cortez MA, Ahn YH, Byers LA, Zhang X, Yi X, Dwyer D, Lin W, Diao L, Wang J, Roybal JD, Patel M, Ungewiss C, ... ... Chen L, et al. Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression. Nature Communications. 5: 5241. PMID 25348003 DOI: 10.1038/Ncomms6241  0.396
2014 Wang J, Chen L. Myeloid cells' evasion of melanoma immunity. The Journal of Investigative Dermatology. 134: 2675-7. PMID 25318429 DOI: 10.1038/Jid.2014.251  0.462
2014 Yao S, Chen L. PD-1 as an immune modulatory receptor. Cancer Journal (Sudbury, Mass.). 20: 262-4. PMID 25098286 DOI: 10.1097/Ppo.0000000000000060  0.459
2014 Sanmamed MF, Chen L. Inducible expression of B7-H1 (PD-L1) and its selective role in tumor site immune modulation. Cancer Journal (Sudbury, Mass.). 20: 256-61. PMID 25098285 DOI: 10.1097/Ppo.0000000000000061  0.476
2014 Chen L. From the guest editor: Tumor site immune modulation therapy. Cancer Journal (Sudbury, Mass.). 20: 254-5. PMID 25098284 DOI: 10.1097/Ppo.0000000000000062  0.313
2014 Fujiwara H, Maeda Y, Kobayashi K, Nishimori H, Matsuoka K, Fujii N, Kondo E, Tanaka T, Chen L, Azuma M, Yagita H, Tanimoto M. Programmed death-1 pathway in host tissues ameliorates Th17/Th1-mediated experimental chronic graft-versus-host disease. Journal of Immunology (Baltimore, Md. : 1950). 193: 2565-73. PMID 25080485 DOI: 10.4049/Jimmunol.1400954  0.395
2014 Kohrt HE, Colevas AD, Houot R, Weiskopf K, Goldstein MJ, Lund P, Mueller A, Sagiv-Barfi I, Marabelle A, Lira R, Troutner E, Richards L, Rajapaska A, Hebb J, Chester C, ... ... Chen L, et al. Targeting CD137 enhances the efficacy of cetuximab. The Journal of Clinical Investigation. 124: 2668-82. PMID 24837434 DOI: 10.1172/Jci73014  0.452
2014 Flies DB, Han X, Higuchi T, Zheng L, Sun J, Ye JJ, Chen L. Coinhibitory receptor PD-1H preferentially suppresses CD4⁺ T cell-mediated immunity. The Journal of Clinical Investigation. 124: 1966-75. PMID 24743150 DOI: 10.1172/Jci74589  0.762
2014 Taube JM, Klein A, Brahmer JR, Xu H, Pan X, Kim JH, Chen L, Pardoll DM, Topalian SL, Anders RA. Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 20: 5064-74. PMID 24714771 DOI: 10.1158/1078-0432.Ccr-13-3271  0.348
2014 Chow BJ, Dorbala S, Di Carli MF, Merhige ME, Williams BA, Veledar E, Min JK, Pencina MJ, Yam Y, Chen L, Anand SP, Ruddy TD, Berman DS, Shaw LJ, Beanlands RS. Prognostic value of PET myocardial perfusion imaging in obese patients. Jacc. Cardiovascular Imaging. 7: 278-87. PMID 24560212 DOI: 10.1016/J.Jcmg.2013.12.008  0.558
2014 Scandiuzzi L, Ghosh K, Hofmeyer KA, Abadi YM, Lázár-Molnár E, Lin EY, Liu Q, Jeon H, Almo SC, Chen L, Nathenson SG, Zang X. Tissue-expressed B7-H1 critically controls intestinal inflammation. Cell Reports. 6: 625-32. PMID 24529703 DOI: 10.1016/J.Celrep.2014.01.020  0.465
2014 Velcheti V, Schalper KA, Carvajal DE, Anagnostou VK, Syrigos KN, Sznol M, Herbst RS, Gettinger SN, Chen L, Rimm DL. Programmed death ligand-1 expression in non-small cell lung cancer. Laboratory Investigation; a Journal of Technical Methods and Pathology. 94: 107-16. PMID 24217091 DOI: 10.1038/Labinvest.2013.130  0.356
2014 Zhu Y, Chen L. CD137 as a biomarker for tumor-reactive T cells: finding gold in the desert. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 20: 3-5. PMID 24166912 DOI: 10.1158/1078-0432.Ccr-13-2573  0.5
2014 Wang X, Marr AK, Breitkopf T, Leung G, Hao J, Wang E, Kwong N, Akhoundsadegh N, Chen L, Mui A, Carr N, Warnock GL, Shapiro J, McElwee KJ. Hair follicle mesenchyme-associated PD-L1 regulates T-cell activation induced apoptosis: A potential mechanism of immune privilege Journal of Investigative Dermatology. 134: 736-745. PMID 24005055 DOI: 10.1038/Jid.2013.368  0.397
2014 Jilaveanu LB, Shuch B, Zito CR, Parisi F, Barr M, Kluger Y, Chen L, Kluger HM. PD-L1 expression in clear cell renal cell carcinoma: An analysis of nephrectomy and sites of metastases Journal of Cancer. 5: 166-172. DOI: 10.7150/Jca.8167  0.366
2014 Martínez Gómez JM, Chen L, Schwarz H, Karrasch T. Correction: CD137 facilitates the resolution of acute DSS-induced colonic inflammation in mice (PLoS ONE) Plos One. 9. DOI: 10.1371/Annotation/83Fd162D-B115-4Af3-B6E7-Dc23Ae3F9A76  0.326
2014 Gibbons DL, Chen L, Goswami S, Cortez MA, Ahn Y, Byers LA, Lin W, Diao L, Wang J, Roybal J, Ungewiss C, Antonia SJ, Mediaville-Varela M, Suraokar MB, Welsh J, ... Chen L, et al. Regulation of tumor cell PD-L1 expression by microRNA-200 and control of lung cancer metastasis. Journal of Clinical Oncology. 32: 8063-8063. DOI: 10.1200/Jco.2014.32.15_Suppl.8063  0.391
2014 Deng R, Cassady K, Li X, Yao S, Zhang M, Racine J, Lin J, Chen L, Zeng D. B7H1/B7.1 Interaction Alleviate Acute Gvhd in a PD-1 Dependent Manner Blood. 124: 2423-2423. DOI: 10.1182/Blood.V124.21.2423.2423  0.468
2014 Tan Y, Han X, Wu X, Xing Q, Chen L, Wang S. Anti-TOSO antibody treatment promotes T cell activation-induced cell death （AICD） in vitro and in vivo Chinese Science Bulletin. 59: 1374-1385. DOI: 10.1007/S11434-014-0132-X  0.438
2013 Li Z, Chen L, Rubinstein MP. Cancer immunotherapy: are we there yet? Experimental Hematology & Oncology. 2: 33. PMID 24326015 DOI: 10.1186/2162-3619-2-33  0.377
2013 Martínez Gómez JM, Chen L, Schwarz H, Karrasch T. CD137 facilitates the resolution of acute DSS-induced colonic inflammation in mice. Plos One. 8: e73277. PMID 24023849 DOI: 10.1371/Journal.Pone.0073277  0.384
2013 Zhu Y, Yao S, Iliopoulou BP, Han X, Augustine MM, Xu H, Phennicie RT, Flies SJ, Broadwater M, Ruff W, Taube JM, Zheng L, Luo L, Zhu G, Chen J, ... Chen L, et al. B7-H5 costimulates human T cells via CD28H. Nature Communications. 4: 2043. PMID 23784006 DOI: 10.1038/Ncomms3043  0.551
2013 Podojil JR, Liu LN, Marshall SA, Chiang MY, Goings GE, Chen L, Langermann S, Miller SD. B7-H4Ig inhibits mouse and human T-cell function and treats EAE via IL-10/Treg-dependent mechanisms. Journal of Autoimmunity. 44: 71-81. PMID 23683881 DOI: 10.1016/J.Jaut.2013.04.001  0.462
2013 Lee IF, Wang X, Hao J, Akhoundsadegh N, Chen L, Liu L, Langermann S, Ou D, Warnock GL. B7-H4.Ig inhibits the development of type 1 diabetes by regulating Th17 cells in NOD mice. Cellular Immunology. 282: 1-8. PMID 23623902 DOI: 10.1016/J.Cellimm.2013.03.005  0.427
2013 Jensen KD, Hu K, Whitmarsh RJ, Hassan MA, Julien L, Lu D, Chen L, Hunter CA, Saeij JP. Toxoplasma gondii rhoptry 16 kinase promotes host resistance to oral infection and intestinal inflammation only in the context of the dense granule protein GRA15. Infection and Immunity. 81: 2156-67. PMID 23545295 DOI: 10.1128/Iai.01185-12  0.327
2013 Tang Q, Jiang D, Alonso S, Pant A, Martínez Gómez JM, Kemeny DM, Chen L, Schwarz H. CD137 ligand signaling enhances myelopoiesis during infections. European Journal of Immunology. 43: 1555-67. PMID 23519951 DOI: 10.1002/Eji.201243071  0.399
2013 Chen L, Flies DB. Molecular mechanisms of T cell co-stimulation and co-inhibition. Nature Reviews. Immunology. 13: 227-42. PMID 23470321 DOI: 10.1038/Nri3405  0.703
2013 Sznol M, Chen L. Antagonist antibodies to PD-1 and B7-H1 (PD-L1) in the treatment of advanced human cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 1021-34. PMID 23460533 DOI: 10.1158/1078-0432.Ccr-12-2063  0.476
2013 Yao S, Chen L. Adaptive resistance: a tumor strategy to evade immune attack. European Journal of Immunology. 43: 576-9. PMID 23381914 DOI: 10.1002/Eji.201243275  0.516
2013 Yao S, Zhu Y, Chen L. Advances in targeting cell surface signalling molecules for immune modulation. Nature Reviews. Drug Discovery. 12: 130-46. PMID 23370250 DOI: 10.1038/Nrd3877  0.407
2013 Bigelow E, Bever KM, Xu H, Yager A, Wu A, Taube J, Chen L, Jaffee EM, Anders RA, Zheng L. Immunohistochemical staining of B7-H1 (PD-L1) on paraffin-embedded slides of pancreatic adenocarcinoma tissue. Journal of Visualized Experiments : Jove. PMID 23328703 DOI: 10.3791/4059  0.486
2013 Lyford-Pike S, Peng S, Young GD, Taube JM, Westra WH, Akpeng B, Bruno TC, Richmon JD, Wang H, Bishop JA, Chen L, Drake CG, Topalian SL, Pardoll DM, Pai SI. Evidence for a role of the PD-1:PD-L1 pathway in immune resistance of HPV-associated head and neck squamous cell carcinoma. Cancer Research. 73: 1733-41. PMID 23288508 DOI: 10.1158/0008-5472.Can-12-2384  0.367
2013 Wang X, Hao J, Metzger DL, Mui A, Lee IF, Akhoundsadegh N, Ao Z, Chen L, Ou D, Verchere CB, Warnock GL. Endogenous expression of B7-H4 improves long-term murine islet allograft survival. Transplantation. 95: 94-9. PMID 23192157 DOI: 10.1097/Tp.0B013E318277229D  0.449
2013 Lipson EJ, Sharfman WH, Drake CG, Wollner I, Taube JM, Anders RA, Xu H, Yao S, Pons A, Chen L, Pardoll DM, Brahmer JR, Topalian SL. Durable cancer regression off-treatment and effective reinduction therapy with an anti-PD-1 antibody. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 462-8. PMID 23169436 DOI: 10.1158/1078-0432.Ccr-12-2625  0.333
2013 Tamura H, Ishibashi M, Yamashita T, Tanosaki S, Okuyama N, Kondo A, Hyodo H, Shinya E, Takahashi H, Dong H, Tamada K, Chen L, Dan K, Ogata K. Marrow stromal cells induce B7-H1 expression on myeloma cells, generating aggressive characteristics in multiple myeloma. Leukemia. 27: 464-72. PMID 22828443 DOI: 10.1038/Leu.2012.213  0.48
2013 Infante JR, Powderly JD, Burris HA, Kittaneh M, Grice JH, Smothers JF, Brett S, Fleming ME, May R, Marshall S, Devenport M, Pillemer S, Pardoll DM, Chen L, Langermann S, et al. Clinical and pharmacodynamic (PD) results of a phase I trial with AMP-224 (B7-DC Fc) that binds to the PD-1 receptor. Journal of Clinical Oncology. 31: 3044-3044. DOI: 10.1200/Jco.2013.31.15_Suppl.3044  0.49
2013 Kohrt HE, Houot R, Weiskopf K, Goldstein M, Lund P, Lira RR, Troutner E, Richards L, Rajapaksa A, Ostashko A, Weng W, Chen L, Czerwinski D, Colevas AD, Sunwoo J, et al. Targeting CD137 to enhance the antitumor efficacy of cetuximab by stimulation of innate and adaptive immunity. Journal of Clinical Oncology. 31: 3015-3015. DOI: 10.1200/Jco.2013.31.15_Suppl.3015  0.465
2013 Velcheti V, Schalper K, Carvajal D, Chen L, Sznol M, Gettinger SN, Herbst RS, Rimm D. Clinical significance of programmed death ligand-1 expression in non-small cell lung cancer (NSCLC). Journal of Clinical Oncology. 31: 11075-11075. DOI: 10.1200/Jco.2013.31.15_Suppl.11075  0.359
2013 Fujiwara H, Maeda Y, Kobayashi K, Nishimori H, Matsuoka K, Azuma M, Yagita H, Chen L, Tanimoto M. Host Tissue PD-1 Pathway Contribute To Murine Chronic Graft-Versus-Host Disease Via Th1+Th17+ Cells Blood. 122: 3244-3244. DOI: 10.1182/Blood.V122.21.3244.3244  0.416
2013 LoRusso PM, Powderly J, Burris HA, Kittaneh M, Grice J, Smothers JF, Brett S, Fleming M, May RJ, Marshall S, Devenport M, Pillemer S, Pardoll DM, Chen L, Langermann S, et al. Abstract LB-193: Phase I study of safety, tolerability, pharmacokinetics, and pharmacodynamics of AMP-224 (B7-DC Fc fusion protein) in a regimen containing cyclophosphamide (CTX) in patients with advanced solid tumors. Cancer Research. 73. DOI: 10.1158/1538-7445.Am2013-Lb-193  0.413
2013 Chen L, Flies DB. Erratum: Molecular mechanisms of T cell co-stimulation and co-inhibition Nature Reviews Immunology. 13: 542-542. DOI: 10.1038/Nri3484  0.722
2012 Tewalt EF, Cohen JN, Rouhani SJ, Guidi CJ, Qiao H, Fahl SP, Conaway MR, Bender TP, Tung KS, Vella AT, Adler AJ, Chen L, Engelhard VH. Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells. Blood. 120: 4772-82. PMID 22993390 DOI: 10.1182/Blood-2012-04-427013  0.495
2012 Tzeng HT, Tsai HF, Liao HJ, Lin YJ, Chen L, Chen PJ, Hsu PN. PD-1 blockage reverses immune dysfunction and hepatitis B viral persistence in a mouse animal model. Plos One. 7: e39179. PMID 22761734 DOI: 10.1371/Journal.Pone.0039179  0.434
2012 Topalian SL, Hodi FS, Brahmer JR, Gettinger SN, Smith DC, McDermott DF, Powderly JD, Carvajal RD, Sosman JA, Atkins MB, Leming PD, Spigel DR, Antonia SJ, Horn L, Drake CG, ... ... Chen L, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer New England Journal of Medicine. 366: 2443-2454. PMID 22658127 DOI: 10.1056/Nejmoa1200690  0.392
2012 Voight BF, Peloso GM, Orho-Melander M, Frikke-Schmidt R, Barbalic M, Jensen MK, Hindy G, Hólm H, Ding EL, Johnson T, Schunkert H, Samani NJ, Clarke R, Hopewell JC, Thompson JF, ... ... Chen L, et al. Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet. 380: 572-80. PMID 22607825 DOI: 10.1016/S0140-6736(12)60312-2  0.562
2012 Taube JM, Anders RA, Young GD, Xu H, Sharma R, McMiller TL, Chen S, Klein AP, Pardoll DM, Topalian SL, Chen L. Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape. Science Translational Medicine. 4: 127ra37. PMID 22461641 DOI: 10.1126/Scitranslmed.3003689  0.478
2012 Terme M, Ullrich E, Aymeric L, Meinhardt K, Coudert JD, Desbois M, Ghiringhelli F, Viaud S, Ryffel B, Yagita H, Chen L, Mécheri S, Kaplanski G, Prévost-Blondel A, Kato M, et al. Cancer-induced immunosuppression: IL-18-elicited immunoablative NK cells. Cancer Research. 72: 2757-67. PMID 22427351 DOI: 10.1158/0008-5472.Can-11-3379  0.433
2012 Wilcox RA, Ansell SM, Lim MS, Zou W, Chen L. The B7 homologues and their receptors in hematologic malignancies. European Journal of Haematology. 88: 465-75. PMID 22372959 DOI: 10.1111/J.1600-0609.2012.01766.X  0.408
2012 Kohrt HE, Houot R, Weiskopf K, Goldstein MJ, Scheeren F, Czerwinski D, Colevas AD, Weng WK, Clarke MF, Carlson RW, Stockdale FE, Mollick JA, Chen L, Levy R. Stimulation of natural killer cells with a CD137-specific antibody enhances trastuzumab efficacy in xenotransplant models of breast cancer. The Journal of Clinical Investigation. 122: 1066-75. PMID 22326955 DOI: 10.1172/Jci61226  0.386
2012 Davies RW, Wells GA, Stewart AF, Erdmann J, Shah SH, Ferguson JF, Hall AS, Anand SS, Burnett MS, Epstein SE, Dandona S, Chen L, Nahrstaedt J, Loley C, König IR, et al. A genome-wide association study for coronary artery disease identifies a novel susceptibility locus in the major histocompatibility complex. Circulation. Cardiovascular Genetics. 5: 217-25. PMID 22319020 DOI: 10.1161/Circgenetics.111.961243  0.576
2012 Wang X, Hao J, Metzger DL, Ao Z, Chen L, Ou D, Verchere CB, Mui A, Warnock GL. B7-H4 Treatment of T Cells Inhibits ERK, JNK, p38, and AKT Activation. Plos One. 7: e28232. PMID 22238573 DOI: 10.1371/Journal.Pone.0028232  0.461
2012 Luan Y, Ju J, Luo L, Zhang Z, Wang J, Zhu D-, Cheng L, Zhang S-, Chen L, Wang F-, Wang S. Potential role of soluble B7-H3 in liver immunopathogenesis during chronic HBV infection. Journal of Viral Hepatitis. 19: 23-31. PMID 22187944 DOI: 10.1111/J.1365-2893.2010.01421.X  0.416
2012 Li X, Deng R, He W, Liu C, Wang M, Young J, Meng Z, Du C, Huang W, Chen L, Chen Y, Martin P, Forman S, Zeng D. Loss of B7-H1 expression by recipient parenchymal cells leads to expansion of infiltrating donor CD8+ T cells and persistence of graft-versus-host disease. Journal of Immunology (Baltimore, Md. : 1950). 188: 724-34. PMID 22156590 DOI: 10.4049/Jimmunol.1102630  0.496
2012 Wang X, Hao J, Metzger DL, Mui A, Ao Z, Verchere CB, Chen L, Ou D, Warnock GL. B7-H4 induces donor-specific tolerance in mouse islet allografts. Cell Transplantation. 21: 99-111. PMID 21929869 DOI: 10.3727/096368911X582750  0.431
2012 Park JJ, Anand S, Zhao Y, Matsumura Y, Sakoda Y, Kuramasu A, Strome SE, Chen L, Tamada K. Expression of anti-HVEM single-chain antibody on tumor cells induces tumor-specific immunity with long-term memory. Cancer Immunology, Immunotherapy : Cii. 61: 203-14. PMID 21877247 DOI: 10.1007/S00262-011-1101-8  0.722
2012 Lyford-Pike S, Peng S, Taube JM, Westra WH, Akpeng B, Wang H, Drake CG, Chen L, Topalian SL, Pardoll DM, Pai SI. PD-1:PD-L1(B7-H1) pathway in adaptive resistance: A novel mechanism for tumor immune escape in human papillomavirus-related head and neck cancers. Journal of Clinical Oncology. 30: 5506-5506. DOI: 10.1200/Jco.2012.30.15_Suppl.5506  0.407
2012 Kohrt HE, Houot R, Weiskopf K, Goldstein M, Lund P, Scheeren F, Czerwinski D, Colevas AD, Weng W, Clarke MF, Carlson RW, Sunwoo J, Tedder T, Chen L, Levy R. Effect of stimulation of natural killer cells with an anti-CD137 mAb on the efficacy of trastuzumab, cetuximab, and rituximab. Journal of Clinical Oncology. 30: 2514-2514. DOI: 10.1200/Jco.2012.30.15_Suppl.2514  0.459
2012 Kohrt H, Houot R, Weiskopf K, Goldstein M, Lund P, Czerwinski D, Sunwoo J, Tedder T, Chen L, Levy R. Abstract LB-138: Stimulation of natural killer cells with an anti-CD137 antibody enhances the efficacy trastuzumab, cetuximab, and rituximab in HER2-expressing breast cancer, EGFR+ head and neck cancer, and CD20+ lymphoma Cancer Research. 72. DOI: 10.1158/1538-7445.Am2012-Lb-138  0.442
2011 Flies DB, Sandler BJ, Sznol M, Chen L. Blockade of the B7-H1/PD-1 pathway for cancer immunotherapy. The Yale Journal of Biology and Medicine. 84: 409-21. PMID 22180678  0.704
2011 Sakoda Y, Anand S, Zhao Y, Park JJ, Liu Y, Kuramasu A, van Rooijen N, Chen L, Strome SE, Hancock WW, Chen L, Tamada K. Herpesvirus entry mediator regulates hypoxia-inducible factor-1α and erythropoiesis in mice. The Journal of Clinical Investigation. 121: 4810-9. PMID 22080867 DOI: 10.1172/Jci57332  0.647
2011 Wang X, Hao J, Metzger DL, Ao Z, Meloche M, Verchere CB, Chen L, Ou D, Mui A, Warnock GL. B7-H4 Pathway in Islet Transplantation and β-Cell Replacement Therapies. Journal of Transplantation. 2011: 418902. PMID 22028949 DOI: 10.1155/2011/418902  0.444
2011 Wang X, Hao J, Metzger DL, Mui A, Ao Z, Akhoundsadegh N, Langermann S, Liu L, Chen L, Ou D, Verchere CB, Warnock GL. Early treatment of NOD mice with B7-H4 reduces the incidence of autoimmune diabetes. Diabetes. 60: 3246-55. PMID 21984581 DOI: 10.2337/Db11-0375  0.451
2011 Zheng J, Umikawa M, Zhang S, Huynh H, Silvany R, Chen BP, Chen L, Zhang CC. Ex vivo expanded hematopoietic stem cells overcome the MHC barrier in allogeneic transplantation. Cell Stem Cell. 9: 119-30. PMID 21816363 DOI: 10.1016/J.Stem.2011.06.003  0.342
2011 Flies DB, Wang S, Xu H, Chen L. Cutting edge: A monoclonal antibody specific for the programmed death-1 homolog prevents graft-versus-host disease in mouse models. Journal of Immunology (Baltimore, Md. : 1950). 187: 1537-41. PMID 21768399 DOI: 10.4049/Jimmunol.1100660  0.733
2011 Han X, Ye P, Luo L, Zheng L, Liu Y, Chen L, Wang S. The development and functions of CD4(+) T cells expressing a transgenic TCR specific for an MHC-I-restricted tumor antigenic epitope. Cellular & Molecular Immunology. 8: 333-40. PMID 21643003 DOI: 10.1038/Cmi.2011.14  0.483
2011 Yao S, Zhu Y, Zhu G, Augustine M, Zheng L, Goode DJ, Broadwater M, Ruff W, Flies S, Xu H, Flies D, Luo L, Wang S, Chen L. B7-h2 is a costimulatory ligand for CD28 in human. Immunity. 34: 729-40. PMID 21530327 DOI: 10.1016/J.Immuni.2011.03.014  0.821
2011 Zhu Y, Yao S, Chen L. Cell surface signaling molecules in the control of immune responses: a tide model. Immunity. 34: 466-78. PMID 21511182 DOI: 10.1016/J.Immuni.2011.04.008  0.363
2011 Hams E, McCarron MJ, Amu S, Yagita H, Azuma M, Chen L, Fallon PG. Blockade of B7-H1 (programmed death ligand 1) enhances humoral immunity by positively regulating the generation of T follicular helper cells. Journal of Immunology (Baltimore, Md. : 1950). 186: 5648-55. PMID 21490158 DOI: 10.4049/Jimmunol.1003161  0.492
2011 Mouri Y, Yano M, Shinzawa M, Shimo Y, Hirota F, Nishikawa Y, Nii T, Kiyonari H, Abe T, Uehara H, Izumi K, Tamada K, Chen L, Penninger JM, Inoue J, et al. Lymphotoxin signal promotes thymic organogenesis by eliciting RANK expression in the embryonic thymic stroma. Journal of Immunology (Baltimore, Md. : 1950). 186: 5047-57. PMID 21441458 DOI: 10.4049/Jimmunol.1003533  0.329
2011 Schunkert H, König IR, Kathiresan S, Reilly MP, Assimes TL, Holm H, Preuss M, Stewart AF, Barbalic M, Gieger C, Absher D, Aherrahrou Z, Allayee H, Altshuler D, Anand SS, ... ... Chen L, et al. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nature Genetics. 43: 333-8. PMID 21378990 DOI: 10.1038/Ng.784  0.575
2011 Yi T, Li X, Yao S, Wang L, Chen Y, Zhao D, Johnston HF, Young JS, Liu H, Todorov I, Forman SJ, Chen L, Zeng D. Host APCs augment in vivo expansion of donor natural regulatory T cells via B7H1/B7.1 in allogeneic recipients. Journal of Immunology (Baltimore, Md. : 1950). 186: 2739-49. PMID 21263067 DOI: 10.4049/Jimmunol.1002939  0.47
2011 Kohrt HE, Houot R, Goldstein MJ, Weiskopf K, Alizadeh AA, Brody J, Müller A, Pachynski R, Czerwinski D, Coutre S, Chao MP, Chen L, Tedder TF, Levy R. CD137 stimulation enhances the antilymphoma activity of anti-CD20 antibodies. Blood. 117: 2423-32. PMID 21193697 DOI: 10.1182/Blood-2010-08-301945  0.461
2011 Wang S, Chen L. Immunobiology of cancer therapies targeting CD137 and B7-H1/PD-1 cosignal pathways. Current Topics in Microbiology and Immunology. 344: 245-67. PMID 20582531 DOI: 10.1007/82_2010_81  0.497
2011 Tamura H, Ishibashi M, Yamashita T, Kondo A, Okuyama N, Hyodo H, Hamada Y, Dan K, Chen L, Ogata K. B7-H1 Molecules on Myeloma Cells Induce Aggressive Cell Behavior Blood. 118: 474-474. DOI: 10.1182/Blood.V118.21.474.474  0.462
2011 Li X, He W, Deng R, Liu C, Wang M, Young J, Chen L, Chen Y, Martin PJ, Forman S, Zeng D. Tissue Parenchymal Cell Expression of B7-H1 Inhibits Infiltrating T Cell Expansion and Prevents Persistence of Graft-Versus-Host Disease Blood. 118: 2974-2974. DOI: 10.1182/Blood.V118.21.2974.2974  0.519
2010 Hamel KM, Cao Y, Wang Y, Rodeghero R, Kobezda T, Chen L, Finnegan A. B7-H1 expression on non-B and non-T cells promotes distinct effects on T- and B-cell responses in autoimmune arthritis. European Journal of Immunology. 40: 3117-27. PMID 21061440 DOI: 10.1002/Eji.201040690  0.565
2010 Wang J, Zhao W, Cheng L, Guo M, Li D, Li X, Tan Y, Ma S, Li S, Yang Y, Chen L, Wang S. CD137-mediated pathogenesis from chronic hepatitis to hepatocellular carcinoma in hepatitis B virus-transgenic mice. Journal of Immunology (Baltimore, Md. : 1950). 185: 7654-62. PMID 21059892 DOI: 10.4049/Jimmunol.1000927  0.363
2010 Nguyen LT, Ciric B, Van Keulen VP, Rodriguez M, Pease LR, Tamada K, Flies DB, Chen L. Retraction: Immunotherapeutic potential of B7-DC (PD-L2) cross-linking antibody in conferring antitumor immunity. Cancer Research. 70: 9528. PMID 21045150 DOI: 10.1158/0008-5472.Can-10-3461  0.698
2010 Lin PY, Sun L, Thibodeaux SR, Ludwig SM, Vadlamudi RK, Hurez VJ, Bahar R, Kious MJ, Livi CB, Wall SR, Chen L, Zhang B, Shin T, Curiel TJ. B7-H1-dependent sex-related differences in tumor immunity and immunotherapy responses. Journal of Immunology (Baltimore, Md. : 1950). 185: 2747-53. PMID 20686128 DOI: 10.4049/Jimmunol.1000496  0.483
2010 Wang S, Chen L. Structural immunology of costimualtory and coinhibitory molecules. Science China. Life Sciences. 53: 183-9. PMID 20596825 DOI: 10.1007/S11427-010-0043-2  0.396
2010 Fukaya T, Takagi H, Sato Y, Sato K, Eizumi K, Taya H, Shin T, Chen L, Dong C, Azuma M, Yagita H, Malissen B, Sato K. Crucial roles of B7-H1 and B7-DC expressed on mesenteric lymph node dendritic cells in the generation of antigen-specific CD4+Foxp3+ regulatory T cells in the establishment of oral tolerance. Blood. 116: 2266-76. PMID 20574047 DOI: 10.1182/Blood-2009-10-250472  0.501
2010 Brahmer JR, Drake CG, Wollner I, Powderly JD, Picus J, Sharfman WH, Stankevich E, Pons A, Salay TM, McMiller TL, Gilson MM, Wang C, Selby M, Taube JM, Anders R, ... Chen L, et al. Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: Safety, clinical activity, pharmacodynamics, and immunologic correlates Journal of Clinical Oncology. 28: 3167-3175. PMID 20516446 DOI: 10.1200/Jco.2009.26.7609  0.385
2010 Rajasalu T, Brosi H, Schuster C, Spyrantis A, Boehm BO, Chen L, Reimann J, Schirmbeck R. Deficiency in B7-H1 (PD-L1)/PD-1 coinhibition triggers pancreatic β-cell destruction by insulin-specific, murine CD8 T-cells Diabetes. 59: 1966-1973. PMID 20484136 DOI: 10.2337/Db09-1135  0.519
2010 Nguyen LT, Ciric B, Ure DR, Zhou B, Tamada K, Tseng SY, Shin T, Chen L, Dong H, Kyle RA, Rodriguez M, Pease LR. Retraction: Naturally occurring human IgM antibody that binds B7-DC and potentiates T cell stimulation by dendritic cells. Journal of Immunology (Baltimore, Md. : 1950). 184: 6552. PMID 20483792 DOI: 10.4049/Jimmunol.1090031  0.423
2010 Kondo A, Yamashita T, Tamura H, Zhao W, Tsuji T, Shimizu M, Shinya E, Takahashi H, Tamada K, Chen L, Dan K, Ogata K. Interferon-gamma and tumor necrosis factor-alpha induce an immunoinhibitory molecule, B7-H1, via nuclear factor-kappaB activation in blasts in myelodysplastic syndromes. Blood. 116: 1124-31. PMID 20472834 DOI: 10.1182/Blood-2009-12-255125  0.482
2010 Park JJ, Omiya R, Matsumura Y, Sakoda Y, Kuramasu A, Augustine MM, Yao S, Tsushima F, Narazaki H, Anand S, Liu Y, Strome SE, Chen L, Tamada K. B7-H1/CD80 interaction is required for the induction and maintenance of peripheral T-cell tolerance. Blood. 116: 1291-8. PMID 20472828 DOI: 10.1182/Blood-2010-01-265975  0.765
2010 Good-Jacobson KL, Szumilas CG, Chen L, Sharpe AH, Tomayko MM, Shlomchik MJ. PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells. Nature Immunology. 11: 535-42. PMID 20453843 DOI: 10.1038/Ni.1877  0.403
2010 Nguyen LT, Radhakrishnan S, Ciric B, Tamada K, Shin T, Pardoll DM, Chen L, Rodriguez M, Pease LR. Cross-linking the B7 family molecule B7-DC directly activates immune functions of dendritic cells (The Journal of Experimental Medicine (November 18, 2002) 196, 10 (1393-1398)) Journal of Experimental Medicine. 207: 901. PMID 20368577 DOI: 10.1084/Jem.2002146632610R  0.397
2010 Dubrot J, Milheiro F, Alfaro C, Palazón A, Martinez-Forero I, Perez-Gracia JL, Morales-Kastresana A, Romero-Trevejo JL, Ochoa MC, Hervás-Stubbs S, Prieto J, Jure-Kunkel M, Chen L, Melero I. Treatment with anti-CD137 mAbs causes intense accumulations of liver T cells without selective antitumor immunotherapeutic effects in this organ. Cancer Immunology, Immunotherapy : Cii. 59: 1223-33. PMID 20336294 DOI: 10.1007/S00262-010-0846-9  0.43
2010 Narazaki H, Zhu Y, Luo L, Zhu G, Chen L. CD137 agonist antibody prevents cancer recurrence: contribution of CD137 on both hematopoietic and nonhematopoietic cells. Blood. 115: 1941-8. PMID 20068221 DOI: 10.1182/Blood-2008-12-192591  0.438
2010 Ishiwata K, Watanabe N, Guo M, Tomihara K, Brumlik MJ, Yagita H, Pardoll D, Chen L, Shin T. Costimulator B7-DC attenuates strong Th2 responses induced by Nippostrongylus brasiliensis. Journal of Immunology (Baltimore, Md. : 1950). 184: 2086-94. PMID 20065112 DOI: 10.4049/Jimmunol.0804051  0.412
2010 Kohrt HE, Houot R, Goldstein M, Weiskopf K, Chen L, Tedder T, Levy R. CD137 stimulation of natural killer cells to enhance the antilymphoma activity of rituximab. Journal of Clinical Oncology. 28: 8068-8068. DOI: 10.1200/Jco.2010.28.15_Suppl.8068  0.383
2010 Kohrt HE, Houot R, Goldstein MJ, Weiskopf K, Chao M, Chen L, Tedder T, Levy R. Immunomodulation of NK Cells through 4-1BB (CD137) to Improve the Anti-Lymphoma Activity of Rituximab: Antibody-Based Anti-Lymphoma Synergy Blood. 116: 422-422. DOI: 10.1182/Blood.V116.21.422.422  0.444
2010 Wang X, Hao J, Metzger D, Mui A, Ao Z, Verchere CB, Chen L, Ou D, Warnock GL. Over-Expression Of B7-H4 In Beta Cells From Transgenic Mice Prolongs Islet Allograft Survival In Transplantation: 3365 Transplantation. 90: 315. DOI: 10.1097/00007890-201007272-00594  0.339
2010 Wang X, Hao J, Metzger D, Mui A, Ao Z, Verchere CB, Chen L, Ou D, Warnock GL. Combination Therapy With B7-H4 and Ctla-4.ig Prolongs Islet Allograft Survival: 2743 Transplantation. 90: 87. DOI: 10.1097/00007890-201007272-00167  0.331
2010 Hamel KM, Cao Y, Wang Y, Rodeghero R, Kobezda T, Chen L, Finnegan A. Cover Picture: Eur. J. Immunol. 11/10 European Journal of Immunology. 40: n/a-n/a. DOI: 10.1002/Eji.201090062  0.445
2009 Omiya R, Tsushima F, Narazaki H, Sakoda Y, Kuramasu A, Kim Y, Xu H, Tamura H, Zhu G, Chen L, Tamada K. Leucocyte-associated immunoglobulin-like receptor-1 is an inhibitory regulator of contact hypersensitivity. Immunology. 128: 543-55. PMID 19930044 DOI: 10.1111/J.1365-2567.2009.03140.X  0.421
2009 Azuma T, Zhu G, Xu H, Rietz AC, Drake CG, Matteson EL, Chen L. Potential role of decoy B7-H4 in the pathogenesis of rheumatoid arthritis: a mouse model informed by clinical data. Plos Medicine. 6: e1000166. PMID 19841745 DOI: 10.1371/Journal.Pmed.1000166  0.416
2009 Wu K, Kryczek I, Chen L, Zou W, Welling TH. Kupffer cell suppression of CD8+ T cells in human hepatocellular carcinoma is mediated by B7-H1/programmed death-1 interactions. Cancer Research. 69: 8067-75. PMID 19826049 DOI: 10.1158/0008-5472.Can-09-0901  0.494
2009 Karim R, Jordanova ES, Piersma SJ, Kenter GG, Chen L, Boer JM, Melief CJ, van der Burg SH. Tumor-expressed B7-H1 and B7-DC in relation to PD-1+ T-cell infiltration and survival of patients with cervical carcinoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 6341-7. PMID 19825956 DOI: 10.1158/1078-0432.Ccr-09-1652  0.47
2009 Houot R, Goldstein MJ, Kohrt HE, Myklebust JH, Alizadeh AA, Lin JT, Irish JM, Torchia JA, Kolstad A, Chen L, Levy R. Therapeutic effect of CD137 immunomodulation in lymphoma and its enhancement by Treg depletion. Blood. 114: 3431-8. PMID 19641184 DOI: 10.1182/Blood-2009-05-223958  0.47
2009 Yi T, Chen Y, Wang L, Du G, Huang D, Zhao D, Johnston H, Young J, Todorov I, Umetsu DT, Chen L, Iwakura Y, Kandeel F, Forman S, Zeng D. Reciprocal differentiation and tissue-specific pathogenesis of Th1, Th2, and Th17 cells in graft-versus-host disease. Blood. 114: 3101-12. PMID 19602708 DOI: 10.1182/Blood-2009-05-219402  0.395
2009 Sun Y, Brown NK, Ruddy MJ, Miller ML, Lee Y, Wang Y, Murphy KM, Pfeffer K, Chen L, Kaye J, Fu YX. B and T lymphocyte attenuator tempers early infection immunity. Journal of Immunology (Baltimore, Md. : 1950). 183: 1946-51. PMID 19587015 DOI: 10.4049/Jimmunol.0801866  0.408
2009 Yi KH, Chen L. Fine tuning the immune response through B7-H3 and B7-H4. Immunological Reviews. 229: 145-51. PMID 19426220 DOI: 10.1111/J.1600-065X.2009.00768.X  0.423
2009 Phares TW, Ramakrishna C, Parra GI, Epstein A, Chen L, Atkinson R, Stohlman SA, Bergmann CC. Target-dependent B7-H1 regulation contributes to clearance of central nervous system infection and dampens morbidity. Journal of Immunology (Baltimore, Md. : 1950). 182: 5430-8. PMID 19380790 DOI: 10.4049/Jimmunol.0803557  0.519
2009 Yao S, Wang S, Zhu Y, Luo L, Zhu G, Flies S, Xu H, Ruff W, Broadwater M, Choi IH, Tamada K, Chen L. PD-1 on dendritic cells impedes innate immunity against bacterial infection. Blood. 113: 5811-8. PMID 19339692 DOI: 10.1182/Blood-2009-02-203141  0.438
2009 Wang X, Hao J, Metzger DL, Mui A, Ao Z, Verchere CB, Chen L, Ou D, Warnock GL. Local expression of B7-H4 by recombinant adenovirus transduction in mouse islets prolongs allograft survival. Transplantation. 87: 482-90. PMID 19307783 DOI: 10.1097/Tp.0B013E318195E5Fa  0.425
2009 Melero I, Martinez-Forero I, Dubrot J, Suarez N, Palazón A, Chen L. Palettes of vaccines and immunostimulatory monoclonal antibodies for combination. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 1507-9. PMID 19240168 DOI: 10.1158/1078-0432.Ccr-08-2931  0.42
2009 Zhu Y, Chen L. Turning the tide of lymphocyte costimulation. Journal of Immunology (Baltimore, Md. : 1950). 182: 2557-8. PMID 19234146 DOI: 10.4049/Jimmunol.0990006  0.42
2009 Talay O, Shen CH, Chen L, Chen J. B7-H1 (PD-L1) on T cells is required for T-cell-mediated conditioning of dendritic cell maturation. Proceedings of the National Academy of Sciences of the United States of America. 106: 2741-6. PMID 19202065 DOI: 10.1073/Pnas.0813367106  0.516
2009 Yamashita T, Tamura H, Satoh C, Shinya E, Takahashi H, Chen L, Kondo A, Tsuji T, Dan K, Ogata K. Functional B7.2 and B7-H2 molecules on myeloma cells are associated with a growth advantage. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 770-7. PMID 19188146 DOI: 10.1158/1078-0432.Ccr-08-0501  0.463
2009 Zhu G, Augustine MM, Azuma T, Luo L, Yao S, Anand S, Rietz AC, Huang J, Xu H, Flies AS, Flies SJ, Tamada K, Colonna M, van Deursen JM, Chen L. B7-H4-deficient mice display augmented neutrophil-mediated innate immunity. Blood. 113: 1759-67. PMID 19109567 DOI: 10.1182/Blood-2008-01-133223  0.726
2009 Crane CA, Panner A, Murray JC, Wilson SP, Xu H, Chen L, Simko JP, Waldman FM, Pieper RO, Parsa AT. PI(3) kinase is associated with a mechanism of immunoresistance in breast and prostate cancer. Oncogene. 28: 306-12. PMID 18850006 DOI: 10.1038/Onc.2008.384  0.392
2009 Houot R, Goldstein MJ, Kohrt HE, Myklebust JH, Alizadeh AA, Lin JT, Irish JM, Torchia JA, Kolstad A, Chen L, Levy R. Therapeutic Potential of Anti-CD137 Antibody in Lymphoma. Blood. 114: 722-722. DOI: 10.1182/Blood.V114.22.722.722  0.462
2009 Kondo A, Tamura H, Yamashita T, Sato C, Wanhong Z, Tsuji T, Shinya E, Takahashi H, Tamada K, Chen L, Dan K, Ogata K. Interferon-γ and Tumor Necrosis Factor-α Induce An Immunoinhibitory Molecule, B7-H1, Via NfκB Activation in Blasts of Myelodysplastic Syndromes. Blood. 114: 2766-2766. DOI: 10.1182/Blood.V114.22.2766.2766  0.522
2008 Hermes G, Ajioka JW, Kelly KA, Mui E, Roberts F, Kasza K, Mayr T, Kirisits MJ, Wollmann R, Ferguson DJ, Roberts CW, Hwang JH, Trendler T, Kennan RP, Suzuki Y, ... ... Chen L, et al. Neurological and behavioral abnormalities, ventricular dilatation, altered cellular functions, inflammation, and neuronal injury in brains of mice due to common, persistent, parasitic infection. Journal of Neuroinflammation. 5: 48. PMID 18947414 DOI: 10.1186/1742-2094-5-48  0.319
2008 Kryczek I, Wei S, Gong W, Shu X, Szeliga W, Vatan L, Chen L, Wang G, Zou W. Cutting edge: IFN-gamma enables APC to promote memory Th17 and abate Th1 cell development. Journal of Immunology (Baltimore, Md. : 1950). 181: 5842-6. PMID 18941172 DOI: 10.4049/Jimmunol.181.9.5842  0.342
2008 Anand S, Fan VY, Zhang J, Zhang L, Ke Y, Dong Z, Chen LC. China's human resources for health: quantity, quality, and distribution. Lancet (London, England). 372: 1774-81. PMID 18930528 DOI: 10.1016/S0140-6736(08)61363-X  0.557
2008 Schreiner B, Bailey SL, Shin T, Chen L, Miller SD. PD-1 ligands expressed on myeloid-derived APC in the CNS regulate T-cell responses in EAE. European Journal of Immunology. 38: 2706-17. PMID 18825752 DOI: 10.1002/Eji.200838137  0.51
2008 Wahl C, Bochtler P, Chen L, Schirmbeck R, Reimann J. B7-H1 on hepatocytes facilitates priming of specific CD8 T cells but limits the specific recall of primed responses. Gastroenterology. 135: 980-8. PMID 18621049 DOI: 10.1053/J.Gastro.2008.05.076  0.529
2008 Wei S, Shreiner AB, Takeshita N, Chen L, Zou W, Chang AE. Tumor-induced immune suppression of in vivo effector T-cell priming is mediated by the B7-H1/PD-1 axis and transforming growth factor beta. Cancer Research. 68: 5432-8. PMID 18593946 DOI: 10.1158/0008-5472.Can-07-6598  0.511
2008 Lin W, Voskens CJ, Zhang X, Schindler DG, Wood A, Burch E, Wei Y, Chen L, Tian G, Tamada K, Wang LX, Schulze DH, Mann D, Strome SE. Fc-dependent expression of CD137 on human NK cells: insights into "agonistic" effects of anti-CD137 monoclonal antibodies. Blood. 112: 699-707. PMID 18519814 DOI: 10.1182/Blood-2007-11-122465  0.411
2008 Zou W, Chen L. Inhibitory B7-family molecules in the tumour microenvironment. Nature Reviews. Immunology. 8: 467-77. PMID 18500231 DOI: 10.1038/Nri2326  0.419
2008 Lafon M, Mégret F, Meuth SG, Simon O, Velandia Romero ML, Lafage M, Chen L, Alexopoulou L, Flavell RA, Prehaud C, Wiendl H. Detrimental contribution of the immuno-inhibitor B7-H1 to rabies virus encephalitis. Journal of Immunology (Baltimore, Md. : 1950). 180: 7506-15. PMID 18490751 DOI: 10.4049/Jimmunol.180.11.7506  0.429
2008 Ortler S, Leder C, Mittelbronn M, Zozulya AL, Knolle PA, Chen L, Kroner A, Wiendl H. B7-H1 restricts neuroantigen-specific T cell responses and confines inflammatory CNS damage: Implications for the lesion pathogenesis of multiple sclerosis European Journal of Immunology. 38: 1734-1744. PMID 18421793 DOI: 10.1002/Eji.200738071  0.507
2008 Olofsson PS, Söderström LA, Wågsäter D, Sheikine Y, Ocaya P, Lang F, Rabu C, Chen L, Rudling M, Aukrust P, Hedin U, Paulsson-Berne G, Sirsjö A, Hansson GK. CD137 is expressed in human atherosclerosis and promotes development of plaque inflammation in hypercholesterolemic mice. Circulation. 117: 1292-301. PMID 18285570 DOI: 10.1161/Circulationaha.107.699173  0.353
2008 Azuma T, Yao S, Zhu G, Flies AS, Flies SJ, Chen L. B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells. Blood. 111: 3635-43. PMID 18223165 DOI: 10.1182/Blood-2007-11-123141  0.493
2008 Jeong HY, Lee YJ, Seo SK, Lee SW, Park SJ, Lee JN, Sohn HS, Yao S, Chen L, Choi I. Blocking of monocyte-associated B7-H1 (CD274) enhances HCV-specific T cell immunity in chronic hepatitis C infection. Journal of Leukocyte Biology. 83: 755-64. PMID 18086898 DOI: 10.1189/Jlb.0307168  0.478
2008 McNamara JO, Kolonias D, Pastor F, Mittler RS, Chen L, Giangrande PH, Sullenger B, Gilboa E. Multivalent 4-1BB binding aptamers costimulate CD8+ T cells and inhibit tumor growth in mice. The Journal of Clinical Investigation. 118: 376-86. PMID 18060045 DOI: 10.1172/Jci33365  0.483
2008 Seo S, Jeong H, Park S, Lee S, Choi I, Chen L, Choi I. Blockade of endogenous B7-H1 suppresses antibacterial protection after primary Listeria monocytogenes infection. Immunology. 123: 90-99. PMID 17971153 DOI: 10.1111/J.1365-2567.2007.02708.X  0.529
2008 Chen Y, Lin C, Li N, Du G, Chen L, Forman S, Zeng D. Radiation-Free Anti-CD3-Conditioning Regimen Maintains Tissue Protection Mechanisms and Prevents GVHD: Role of Tissue Expression of B7H1 Blood. 112: 62-62. DOI: 10.1182/Blood.V112.11.62.62  0.421
2008 Yamashita T, Tamura H, Sato C, Kondo A, Shinya E, Takahashi H, Chen L, Tsuji T, Dan K, Ogata K. Expression and Function of B7.2 and B7-H2 Molecules on Myeloma Cells Blood. 112: 2722-2722. DOI: 10.1182/Blood.V112.11.2722.2722  0.467
2007 Diehl L, Schurich A, Grochtmann R, Hegenbarth S, Chen L, Knolle PA. Tolerogenic maturation of liver sinusoidal endothelial cells promotes B7-homolog 1-dependent CD8+ T cell tolerance. Hepatology. 47: 296-305. PMID 17975811 DOI: 10.1002/Hep.21965  0.482
2007 Pentcheva-Hoang T, Chen L, Pardoll DM, Allison JP. Programmed death-1 concentration at the immunological synapse is determined by ligand affinity and availability. Proceedings of the National Academy of Sciences of the United States of America. 104: 17765-70. PMID 17968013 DOI: 10.1073/Pnas.0708767104  0.488
2007 Kryczek I, Wei S, Zhu G, Myers L, Mottram P, Cheng P, Chen L, Coukos G, Zou W. Relationship between B7-H4, regulatory T cells, and patient outcome in human ovarian carcinoma. Cancer Research. 67: 8900-5. PMID 17875732 DOI: 10.1158/0008-5472.Can-07-1866  0.504
2007 Xu Y, Tamada K, Chen L. LIGHT-related molecular network in the regulation of innate and adaptive immunity. Immunologic Research. 37: 17-32. PMID 17496344 DOI: 10.1007/Bf02686093  0.309
2007 Chen L, Zhang Z, Chen W, Zhang Z, Li Y, Shi M, Zhang J, Chen L, Wang S, Wang FS. B7-H1 up-regulation on myeloid dendritic cells significantly suppresses T cell immune function in patients with chronic hepatitis B. Journal of Immunology (Baltimore, Md. : 1950). 178: 6634-41. PMID 17475895 DOI: 10.4049/Jimmunol.178.10.6634  0.47
2007 Flies DB, Chen L. The new B7s: playing a pivotal role in tumor immunity. Journal of Immunotherapy (Hagerstown, Md. : 1997). 30: 251-60. PMID 17414316 DOI: 10.1097/Cji.0B013E31802E085A  0.723
2007 Goldberg MV, Maris CH, Hipkiss EL, Flies AS, Zhen L, Tuder RM, Grosso JF, Harris TJ, Getnet D, Whartenby KA, Brockstedt DG, Dubensky TW, Chen L, Pardoll DM, Drake CG. Role of PD-1 and its ligand, B7-H1, in early fate decisions of CD8 T cells. Blood. 110: 186-92. PMID 17392506 DOI: 10.1182/Blood-2006-12-062422  0.507
2007 Niu L, Strahotin S, Hewes B, Zhang B, Zhang Y, Archer D, Spencer T, Dillehay D, Kwon B, Chen L, Vella AT, Mittler RS. Cytokine-mediated disruption of lymphocyte trafficking, hemopoiesis, and induction of lymphopenia, anemia, and thrombocytopenia in anti-CD137-treated mice. Journal of Immunology (Baltimore, Md. : 1950). 178: 4194-213. PMID 17371976 DOI: 10.4049/Jimmunol.178.7.4194  0.477
2007 Tsushima F, Yao S, Shin T, Flies A, Flies S, Xu H, Tamada K, Pardoll DM, Chen L. Interaction between B7-H1 and PD-1 determines initiation and reversal of T-cell anergy. Blood. 110: 180-5. PMID 17289811 DOI: 10.1182/Blood-2006-11-060087  0.489
2007 Zhu Y, Zhu G, Luo L, Flies AS, Chen L. CD137 stimulation delivers an antigen-independent growth signal for T lymphocytes with memory phenotype. Blood. 109: 4882-9. PMID 17244673 DOI: 10.1182/Blood-2006-10-043463  0.447
2007 Piconi S, Trabattoni D, Saresella M, Iemoli E, Schenal M, Fusi A, Borelli M, Chen L, Mascheri A, Clerici M. Effects of Specific Immunotherapy on the B7 Family of Costimulatory Molecules in Allergic Inflammation Journal of Immunology. 178: 1931-1937. PMID 17237444 DOI: 10.4049/Jimmunol.178.3.1931  0.442
2007 Xu Y, Flies AS, Flies DB, Zhu G, Anand S, Flies SJ, Xu H, Anders RA, Hancock WW, Chen L, Tamada K. Selective targeting of the LIGHT-HVEM costimulatory system for the treatment of graft-versus-host disease. Blood. 109: 4097-104. PMID 17179227 DOI: 10.1182/Blood-2006-09-047332  0.794
2006 Ou D, Wang X, Metzger DL, Ao Z, Pozzilli P, James RFL, Chen L, Warnock GL. Suppression of Human T-Cell Responses to β-Cells by Activation of B7-H4 Pathway. Cell Transplantation. 15: 399-410. PMID 28871868 DOI: 10.3727/000000006783981837  0.505
2006 Mohamadzadeh M, Chen L, Olinger GG, Pratt WD, Schmaljohn AL. Filoviruses and the balance of innate, adaptive, and inflammatory responses. Viral Immunology. 19: 602-12. PMID 17201655 DOI: 10.1089/Vim.2006.19.602  0.335
2006 Zhang X, Dong H, Lin W, Voss S, Hinkley L, Westergren M, Tian G, Berry D, Lewellen D, Vile RG, Chen L, Farber DL, Strome SE. Human bone marrow: a reservoir for "enhanced effector memory" CD8+ T cells with potent recall function. Journal of Immunology (Baltimore, Md. : 1950). 177: 6730-7. PMID 17082586 DOI: 10.4049/Jimmunol.177.10.6730  0.445
2006 Ou D, Wang X, Metzger DL, Ao Z, Pozzilli P, James RF, Chen L, Warnock GL. Suppression of human T-cell responses to beta-cells by activation of B7-H4 pathway. Cell Transplantation. 15: 399-410. PMID 16970282  0.403
2006 Flies DB, Chen L. Modulation of immune response by B7 family molecules in tumor microenvironments. Immunological Investigations. 35: 395-418. PMID 16916759 DOI: 10.1080/08820130600755017  0.697
2006 Sun Y, Blink SE, Liu W, Lee Y, Chen B, Solway J, Weinstock J, Chen L, Fu YX. Inhibition of Th2-mediated allergic airway inflammatory disease by CD137 costimulation. Journal of Immunology (Baltimore, Md. : 1950). 177: 814-21. PMID 16818735 DOI: 10.4049/Jimmunol.177.2.814  0.444
2006 Salih HR, Wintterle S, Krusch M, Kroner A, Huang Y, Chen L, Wiendl H. The role of leukemia-derived B7-H1 (PD-L1) in tumor-T-cell interactions in humans. Experimental Hematology. 34: 888-894. PMID 16797416 DOI: 10.1016/J.Exphem.2006.03.006  0.545
2006 Kryczek I, Wei S, Zou L, Zhu G, Mottram P, Xu H, Chen L, Zou W. Cutting edge: induction of B7-H4 on APCs through IL-10: novel suppressive mode for regulatory T cells. Journal of Immunology (Baltimore, Md. : 1950). 177: 40-4. PMID 16785496 DOI: 10.4049/Jimmunol.177.1.40  0.45
2006 Yao S, Chen L. Reviving exhausted T lymphocytes during chronic virus infection by B7-H1 blockade Trends in Molecular Medicine. 12: 244-246. PMID 16650803 DOI: 10.1016/J.Molmed.2006.04.007  0.439
2006 Kryczek I, Zou L, Rodriguez P, Zhu G, Wei S, Mottram P, Brumlik M, Cheng P, Curiel T, Myers L, Lackner A, Alvarez X, Ochoa A, Chen L, Zou W. B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma. The Journal of Experimental Medicine. 203: 871-81. PMID 16606666 DOI: 10.1084/Jem.20050930  0.467
2006 Anand S, Wang P, Yoshimura K, Choi IH, Hilliard A, Chen YH, Wang CR, Schulick R, Flies AS, Flies DB, Zhu G, Xu Y, Pardoll DM, Chen L, Tamada K. Essential role of TNF family molecule LIGHT as a cytokine in the pathogenesis of hepatitis. The Journal of Clinical Investigation. 116: 1045-51. PMID 16557300 DOI: 10.1172/Jci27083  0.784
2006 Tirapu I, Huarte E, Guiducci C, Arina A, Zaratiegui M, Murillo O, Gonzalez A, Berasain C, Berraondo P, Fortes P, Prieto J, Colombo MP, Chen L, Melero I. Low surface expression of B7-1 (CD80) is an immunoescape mechanism of colon carcinoma Cancer Research. 66: 2442-2450. PMID 16489051 DOI: 10.1158/0008-5472.Can-05-1681  0.464
2006 Lee SJ, Jang BC, Lee SW, Yang YI, Suh SI, Park YM, Oh S, Shin JG, Yao S, Chen L, Choi IH. Interferon regulatory factor-1 is prerequisite to the constitutive expression and IFN-gamma-induced upregulation of B7-H1 (CD274). Febs Letters. 580: 755-62. PMID 16413538 DOI: 10.1016/J.Febslet.2005.12.093  0.446
2006 Wang S, Chen L. T lymphocyte co-signaling pathways of the B7-CD28 family. Cellular & Molecular Immunology. 1: 37-42. PMID 16212919  0.354
2006 Tamada K, Chen L. Renewed interest in cancer immunotherapy with the tumor necrosis factor superfamily molecules. Cancer Immunology, Immunotherapy : Cii. 55: 355-62. PMID 16187084 DOI: 10.1007/S00262-005-0081-Y  0.392
2006 Shlomchik WD, Matte-Martone CC, Gilliland DG, Chen L. Mechanisms of GVL Against a Murine Blast Crisis CML. Blood. 108: 191-191. DOI: 10.1182/Blood.V108.11.191.191  0.459
2006 Benedetto AD, Myers AC, McGirt L, Chen L, Brummet M, Schleimer RP, Beck LA. Co-Signalling Molecules (B7 homologs) are Expressed by Human Keratinocytes The Journal of Allergy and Clinical Immunology. 117. DOI: 10.1016/J.Jaci.2005.12.1063  0.313
2005 Jun H, Seo SK, Jeong HY, Seo HM, Zhu G, Chen L, Choi IH. B7-H1 (CD274) inhibits the development of herpetic stromal keratitis (HSK). Febs Letters. 579: 6259-6264. PMID 16253242 DOI: 10.1016/J.Febslet.2005.09.098  0.532
2005 Melero I, Arina A, Chen L. The many sounds of T lymphocyte silence. Immunologic Research. 33: 135-147. PMID 16234580 DOI: 10.1385/Ir:33:2:135  0.459
2005 de Haij S, Woltman AM, Trouw LA, Bakker AC, Kamerling SW, van der Kooij SW, Chen L, Kroczek RA, Daha MR, van Kooten C. Renal tubular epithelial cells modulate T-cell responses via ICOS-L and B7-H1. Kidney International. 68: 2091-102. PMID 16221208 DOI: 10.1111/J.1523-1755.2005.00665.X  0.467
2005 Thompson RH, Gillett MD, Cheville JC, Lohse CM, Dong H, Webster WS, Chen L, Zincke H, Blute ML, Leibovich BC, Kwon ED. Costimulatory molecule B7-H1 in primary and metastatic clear cell renal cell carcinoma. Cancer. 104: 2084-91. PMID 16208700 DOI: 10.1002/cncr.21470  0.323
2005 Tamura H, Dan K, Tamada K, Nakamura K, Shioi Y, Hyodo H, Wang SD, Dong H, Chen L, Ogata K. Expression of functional B7-H2 and B7.2 costimulatory molecules and their prognostic implications in de novo acute myeloid leukemia. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 11: 5708-17. PMID 16115907 DOI: 10.1158/1078-0432.Ccr-04-2672  0.434
2005 Vassallo R, Tamada K, Lau JS, Kroening PR, Chen L. Cigarette smoke extract suppresses human dendritic cell function leading to preferential induction of Th-2 priming. Journal of Immunology (Baltimore, Md. : 1950). 175: 2684-91. PMID 16081845 DOI: 10.4049/Jimmunol.175.4.2684  0.349
2005 Ichikawa M, Chen L. Role of B7-H1 and B7-H4 molecules in down-regulating effector phase of T-cell immunity: novel cancer escaping mechanisms. Frontiers in Bioscience. 10: 2856. PMID 15970540 DOI: 10.2741/1742  0.465
2005 Kim J, Myers AC, Chen L, Pardoll DM, Truong-Tran QA, Lane AP, McDyer JF, Fortuno L, Schleimer RP. Constitutive and inducible expression of b7 family of ligands by human airway epithelial cells. American Journal of Respiratory Cell and Molecular Biology. 33: 280-9. PMID 15961727 DOI: 10.1165/Rcmb.2004-0129Oc  0.465
2005 Shin T, Yoshimura K, Shin T, Crafton EB, Tsuchiya H, Housseau F, Koseki H, Schulick RD, Chen L, Pardoll DM. In vivo costimulatory role of B7-DC in tuning T helper cell 1 and cytotoxic T lymphocyte responses. The Journal of Experimental Medicine. 201: 1531-41. PMID 15897272 DOI: 10.1084/Jem.20050072  0.515
2005 Arribillaga L, Sarobe P, Arina A, Gorraiz M, Borrás-Cuesta F, Ruiz J, Prieto J, Chen L, Melero I, Lasarte JJ. Enhancement of CD4 and CD8 immunity by anti-CD137 (4-1BB) monoclonal antibodies during hepatitis C vaccination with recombinant adenovirus. Vaccine. 23: 3493-3499. PMID 15855007 DOI: 10.1016/J.Vaccine.2005.02.003  0.35
2005 Magnus T, Schreiner B, Korn T, Jack C, Guo H, Antel J, Ifergan I, Chen L, Bischof F, Bar-Or A, Wiendl H. Microglial expression of the B7 family member B7 homolog 1 confers strong immune inhibition: implications for immune responses and autoimmunity in the CNS. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 2537-46. PMID 15758163 DOI: 10.1523/Jneurosci.4794-04.2005  0.525
2005 Hirano F, Kaneko K, Tamura H, Dong H, Wang S, Ichikawa M, Rietz C, Flies DB, Lau JS, Zhu G, Tamada K, Chen L. Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity. Cancer Research. 65: 1089-96. PMID 15705911  0.743
2005 Wang L, Fraser CC, Kikly K, Wells AD, Han R, Coyle AJ, Chen L, Hancock WW. B7-H3 promotes acute and chronic allograft rejection European Journal of Immunology. 35: 428-438. PMID 15682454 DOI: 10.1002/Eji.200425518  0.492
2005 Shao H, Fu Y, Liao T, Peng Y, Chen L, Kaplan HJ, Sun D. Anti-CD137 mAb treatment inhibits experimental autoimmune uveitis by limiting expansion and increasing apoptotic death of uveitogenic T cells. Investigative Ophthalmology & Visual Science. 46: 596-603. PMID 15671287 DOI: 10.1167/Iovs.04-0835  0.474
2005 Krusch M, Wintterle S, Chen L, Kanz L, Wiendl H, Salih HR. The Role of Leukemia Derived B7-H1 in Tumor-T-Cell Interactions in Humans. Blood. 106: 4566-4566. DOI: 10.1182/Blood.V106.11.4566.4566  0.538
2005 Chen L. B7-H1 connection of innate and adaptive immunity against tumor dormancy Blood. 105: 2242-2243. DOI: 10.1182/Blood-2004-12-4845  0.484
2005 Thompson RH, Gillett MD, Cheville JC, Lohse CM, Dong H, Webster WS, Krejci KG, Lobo JR, Sengupta S, Chen L, Zincke H, Blute ML, Strome SE, Leibovich BC, Kwon ED. 618: Costimulatory B7-H1 In Renal Cell Carcinoma Patients: Indicator of Tumor Aggressiveness and Potential Therapeutic Target The Journal of Urology. 173: 169-169. DOI: 10.1016/S0022-5347(18)34858-4  0.368
2004 Mukherjee P, Tinder TL, Basu GD, Pathangey LB, Chen L, Gendler SJ. Therapeutic efficacy of MUC1-specific cytotoxic T lymphocytes and CD137 co-stimulation in a spontaneous breast cancer model. Breast Disease. 20: 53-63. PMID 15687707 DOI: 10.3233/Bd-2004-20107  0.451
2004 Li D, Gál I, Vermes C, Alegre ML, Chong AS, Chen L, Shao Q, Adarichev V, Xu X, Koreny T, Mikecz K, Finnegan A, Glant TT, Zhang J. Cutting edge: Cbl-b: one of the key molecules tuning CD28- and CTLA-4-mediated T cell costimulation. Journal of Immunology (Baltimore, Md. : 1950). 173: 7135-9. PMID 15585834 DOI: 10.4049/Jimmunol.173.12.7135  0.503
2004 Thompson RH, Gillett MD, Cheville JC, Lohse CM, Dong H, Webster WS, Krejci KG, Lobo JR, Sengupta S, Chen L, Zincke H, Blute ML, Strome SE, Leibovich BC, Kwon ED. Costimulatory B7-H1 in renal cell carcinoma patients: Indicator of tumor aggressiveness and potential therapeutic target. Proceedings of the National Academy of Sciences of the United States of America. 101: 17174-9. PMID 15569934 DOI: 10.1073/pnas.0406351101  0.374
2004 Chen L, Evans T, Anand S, Boufford JI, Brown H, Chowdhury M, Cueto M, Dare L, Dussault G, Elzinga G, Fee E, Habte D, Hanvoravongchai P, Jacobs M, Kurowski C, et al. Human resources for health: overcoming the crisis. Lancet (London, England). 364: 1984-90. PMID 15567015 DOI: 10.1016/S0140-6736(04)17482-5  0.567
2004 Luo L, Chapoval AI, Flies DB, Zhu G, Hirano F, Wang S, Lau JS, Dong H, Tamada K, Flies AS, Liu Y, Chen L. B7-H3 enhances tumor immunity in vivo by costimulating rapid clonal expansion of antigen-specific CD8+ cytolytic T cells. Journal of Immunology (Baltimore, Md. : 1950). 173: 5445-50. PMID 15494491 DOI: 10.4049/Jimmunol.173.9.5445  0.776
2004 Schreiner B, Mitsdoerffer M, Kieseier BC, Chen L, Hartung HP, Weller M, Wiendl H. Interferon-β enhances monocyte and dendritic cell expression of B7-H1 (PD-L1), a strong inhibitor of autologous T-cell activation: Relevance for the immune modulatory effect in multiple sclerosis Journal of Neuroimmunology. 155: 172-182. PMID 15342209 DOI: 10.1016/J.Jneuroim.2004.06.013  0.509
2004 Curiel TJ, Coukos G, Zou L, Alvarez X, Cheng P, Mottram P, Evdemon-Hogan M, Conejo-Garcia JR, Zhang L, Burow M, Zhu Y, Wei S, Kryczek I, Daniel B, Gordon A, ... ... Chen L, et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nature Medicine. 10: 942-9. PMID 15322536 DOI: 10.1038/Nm1093  0.491
2004 Radhakrishnan S, Nguyen LT, Ciric B, Flies D, Van Keulen VP, Tamada K, Chen L, Rodriguez M, Pease LR. Immunotherapeutic potential of B7-DC (PD-L2) cross-linking antibody in conferring antitumor immunity. Cancer Research. 64: 4965-72. PMID 15256470 DOI: 10.1158/0008-5472.Can-03-3025  0.741
2004 Wang S, Chen L. Co-signaling molecules of the B7-CD28 family in positive and negative regulation of T lymphocyte responses Microbes and Infection. 6: 759-766. PMID 15207823 DOI: 10.1016/J.Micinf.2004.03.007  0.499
2004 Vassallo R, Chen L. Selective suppression of dendritic cell functions by cigarette smoke extract. Chest. 125: 107S. PMID 15136445 DOI: 10.1378/Chest.125.5_Suppl.107S  0.349
2004 Chen L. Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity. Nature Reviews Immunology. 4: 336-347. PMID 15122199 DOI: 10.1038/Nri1349  0.453
2004 Tirapu I, Arina A, Mazzolini G, Duarte M, Alfaro C, Feijoo E, Qian C, Chen L, Prieto J, Melero I. Improving efficacy of interleukin-12-transfected dendritic cells injected into murine colon cancer with anti-CD137 monoclonal antibodies and alloantigens. International Journal of Cancer. 110: 51-60. PMID 15054868 DOI: 10.1002/Ijc.20093  0.429
2004 Zhang X, Schwartz JC, Guo X, Bhatia S, Cao E, Lorenz M, Cammer M, Chen L, Zhang ZY, Edidin MA, Nathenson SG, Almo SC. Structural and functional analysis of the costimulatory receptor programmed death-1. Immunity. 20: 337-47. PMID 15030777 DOI: 10.1016/S1074-7613(04)00051-2  0.39
2004 Dong H, Zhu G, Tamada K, Flies DB, van Deursen JM, Chen L. B7-H1 determines accumulation and deletion of intrahepatic CD8(+) T lymphocytes. Immunity. 20: 327-36. PMID 15030776 DOI: 10.1016/S1074-7613(04)00050-0  0.74
2004 Subudhi SK, Zhou P, Yerian LM, Chin RK, Lo JC, Anders RA, Sun Y, Chen L, Wang Y, Alegre ML, Fu YX. Local expression of B7-H1 promotes organ-specific autoimmunity and transplant rejection. The Journal of Clinical Investigation. 113: 694-700. PMID 14991067 DOI: 10.1172/Jci19210  0.505
2004 Anand S, Chen L. Control of autoimmune diseases by the B7-CD28 family molecules. Current Pharmaceutical Design. 10: 121-8. PMID 14754392 DOI: 10.2174/1381612043453450  0.699
2004 Rietz C, Chen L. New B7 Family Members with Positive and Negative Costimulatory Function American Journal of Transplantation. 4: 8-14. PMID 14678029 DOI: 10.1046/J.1600-6143.2003.00303.X  0.488
2004 Wintterle S, Schreiner B, Mitsdoerffer M, Schneider D, Chen L, Meyermann R, Weller M, Wiendl H. Expression of the B7-related molecule B7-H1 by glioma cells: a potential mechanism of immune paralysis. Cancer Research. 63: 7462-7. PMID 14612546  0.437
2004 Wilcox RA, Tamada K, Flies DB, Zhu G, Chapoval AI, Blazar BR, Kast WM, Chen L. Ligation of CD137 receptor prevents and reverses established anergy of CD8+ cytolytic T lymphocytes in vivo. Blood. 103: 177-84. PMID 12969968 DOI: 10.1182/Blood-2003-06-2184  0.75
2004 Mukherjee P, Tinder T, Basu GD, Pathangey L, Chen L, Gendler SJ. Therapeutic Efficacy of Muci-Specific Cytotoxic T Lymphocytes and CD137 Co-Stimulation in a Spontaneous Mammary Cancer Model Journal of Immunotherapy. 27: S4. DOI: 10.1097/00002371-200411000-00020  0.41
2004 Kim J, Sanders S, Plitt J, Pardoll D, Chen L, Schleimer R. Modulation of expression of B7 homologs by human rhinovirus and double-stranded RNA in airway epithelial cells in vitro and in vivo The Journal of Allergy and Clinical Immunology. 113. DOI: 10.1016/J.Jaci.2004.01.354  0.411
2003 Morris GP, Chen L, Kong YC. CD137 signaling interferes with activation and function of CD4+CD25+ regulatory T cells in induced tolerance to experimental autoimmune thyroiditis. Cellular Immunology. 226: 20-9. PMID 14746804 DOI: 10.1016/J.Cellimm.2003.11.002  0.423
2003 Tamura H, Ogata K, Dong H, Chen L. Immunology of B7-H1 and its roles in human diseases. International Journal of Hematology. 78: 321-8. PMID 14686489 DOI: 10.1007/Bf02983556  0.483
2003 Lee I, Wang L, Wells AD, Ye Q, Han R, Dorf ME, Kuziel WA, Rollins BJ, Chen L, Hancock WW. Blocking the monocyte chemoattractant protein-1/CCR2 chemokine pathway induces permanent survival of islet allografts through a programmed death-1 ligand-1-dependent mechanism. Journal of Immunology (Baltimore, Md. : 1950). 171: 6929-35. PMID 14662900 DOI: 10.4049/Jimmunol.171.12.6929  0.425
2003 Choi IH, Zhu G, Sica GL, Strome SE, Cheville JC, Lau JS, Zhu Y, Flies DB, Tamada K, Chen L. Genomic organization and expression analysis of B7-H4, an immune inhibitory molecule of the B7 family. Journal of Immunology (Baltimore, Md. : 1950). 171: 4650-4. PMID 14568939 DOI: 10.4049/Jimmunol.171.9.4650  0.726
2003 Strome SE, Dong H, Tamura H, Voss SG, Flies DB, Tamada K, Salomao D, Cheville J, Hirano F, Lin W, Kasperbauer JL, Ballman KV, Chen L. B7-H1 blockade augments adoptive T-cell immunotherapy for squamous cell carcinoma. Cancer Research. 63: 6501-5. PMID 14559843  0.732
2003 Kanai T, Totsuka T, Uraushihara K, Makita S, Nakamura T, Koganei K, Fukushima T, Akiba H, Yagita H, Okumura K, Machida U, Iwai H, Azuma M, Chen L, Watanabe M. Blockade of B7-H1 Suppresses the Development of Chronic Intestinal Inflammation Journal of Immunology. 171: 4156-4163. PMID 14530338 DOI: 10.4049/Jimmunol.171.8.4156  0.519
2003 Wiendl H, Mitsdoerffer M, Schneider D, Chen L, Lochmüller H, Melms A, Weller M. Human muscle cells express a B7-related molecule, B7-H1, with strong negative immune regulatory potential: a novel mechanism of counterbalancing the immune attack in idiopathic inflammatory myopathies The Faseb Journal. 17: 1892-1894. PMID 12923066 DOI: 10.1096/Fj.03-0039Fje  0.527
2003 Youngnak P, Kozono Y, Kozono H, Iwai H, Otsuki N, Jin H, Omura K, Yagita H, Pardoll DM, Chen L, Azuma M. Differential binding properties of B7-H1 and B7-DC to programmed death-1. Biochemical and Biophysical Research Communications. 307: 672-7. PMID 12893276 DOI: 10.1016/S0006-291X(03)01257-9  0.421
2003 Shin T, Kennedy G, Gorski K, Tsuchiya H, Koseki H, Azuma M, Yagita H, Chen L, Powell J, Pardoll D, Housseau F. Cooperative B7-1/2 (CD80/CD86) and B7-DC costimulation of CD4+ T cells independent of the PD-1 receptor. The Journal of Experimental Medicine. 198: 31-8. PMID 12847135 DOI: 10.1084/Jem.20030242  0.489
2003 Sica GL, Choi IH, Zhu G, Tamada K, Wang SD, Tamura H, Chapoval AI, Flies DB, Bajorath J, Chen L. B7-H4, a molecule of the B7 family, negatively regulates T cell immunity. Immunity. 18: 849-61. PMID 12818165 DOI: 10.1016/S1074-7613(03)00152-3  0.759
2003 Flies DB, Chen L. A simple and rapid vortex method for preparing antigen/adjuvant emulsions for immunization. Journal of Immunological Methods. 276: 239-42. PMID 12738377 DOI: 10.1016/S0022-1759(03)00081-4  0.66
2003 Dong H, Chen L. B7-H1 pathway and its role in the evasion of tumor immunity. Journal of Molecular Medicine (Berlin, Germany). 81: 281-7. PMID 12721664 DOI: 10.1007/S00109-003-0430-2  0.536
2003 Wang S, Bajorath J, Flies DB, Dong H, Honjo T, Chen L. Molecular modeling and functional mapping of B7-H1 and B7-DC uncouple costimulatory function from PD-1 interaction. The Journal of Experimental Medicine. 197: 1083-91. PMID 12719480 DOI: 10.1084/Jem.20021752  0.72
2003 Kurosawa S, Myers AC, Chen L, Wang S, Ni J, Plitt JR, Heller NM, Bochner BS, Schleimer RP. Expression of the costimulatory molecule B7-H2 (inducible costimulator ligand) by human airway epithelial cells. American Journal of Respiratory Cell and Molecular Biology. 28: 563-73. PMID 12707012 DOI: 10.1165/Rcmb.2002-0199Oc  0.439
2003 Curiel TJ, Wei S, Dong H, Alvarez X, Cheng P, Mottram P, Krzysiek R, Knutson KL, Daniel B, Zimmermann MC, David O, Burow M, Gordon A, Dhurandhar N, Myers L, ... ... Chen L, et al. Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity. Nature Medicine. 9: 562-7. PMID 12704383 DOI: 10.1038/Nm863  0.522
2003 Petroff MG, Chen L, Phillips TA, Azzola D, Sedlmayr P, Hunt JS. B7 family molecules are favorably positioned at the human maternal-fetal interface. Biology of Reproduction. 68: 1496-504. PMID 12606489 DOI: 10.1095/Biolreprod.102.010058  0.41
2003 Radhakrishnan S, Nguyen LT, Ciric B, Ure DR, Zhou B, Tamada K, Dong H, Tseng SY, Shin T, Pardoll DM, Chen L, Kyle RA, Rodriguez M, Pease LR. Naturally occurring human IgM antibody that binds B7-DC and potentiates T cell stimulation by dendritic cells. Journal of Immunology (Baltimore, Md. : 1950). 170: 1830-8. PMID 12574348  0.309
2003 Dong H, Strome SE, Matteson EL, Moder KG, Flies DB, Zhu G, Tamura H, Driscoll CLW, Chen L. Costimulating aberrant T cell responses by B7-H1 autoantibodies in rheumatoid arthritis Journal of Clinical Investigation. 111: 363-370. PMID 12569162 DOI: 10.1172/Jci16015  0.758
2003 Trabattoni D, Saresella M, Biasin M, Boasso A, Piacentini L, Ferrante P, Dong H, Maserati R, Shearer GM, Chen L, Clerici M. B7-H1 is up-regulated in HIV infection and is a novel surrogate marker of disease progression. Blood. 101: 2514-20. PMID 12468426 DOI: 10.1182/Blood-2002-10-3065  0.426
2003 Plitt JR, Kurasawa S, Chen L, Bochner BS, Schleimer RP. Airway epithelial cells express multiple members of the B7 family The Journal of Allergy and Clinical Immunology. 111. DOI: 10.1016/S0091-6749(03)81016-3  0.337
2002 Nguyen LT, Radhakrishnan S, Ciric B, Tamada K, Shin T, Pardoll DM, Chen L, Rodriguez M, Pease LR. Cross-linking the B7 family molecule B7-DC directly activates immune functions of dendritic cells. The Journal of Experimental Medicine. 196: 1393-8. PMID 12438431 DOI: 10.1084/Jem.20021466  0.407
2002 Sun Y, Chen HM, Subudhi SK, Chen J, Koka R, Chen L, Fu YX. Costimulatory molecule-targeted antibody therapy of a spontaneous autoimmune disease. Nature Medicine. 8: 1405-13. PMID 12426559 DOI: 10.1038/Nm1202-796  0.444
2002 Wilcox RA, Tamada K, Strome SE, Chen L. Signaling through NK cell-associated CD137 promotes both helper function for CD8+ cytolytic T cells and responsiveness to IL-2 but not cytolytic activity. Journal of Immunology (Baltimore, Md. : 1950). 169: 4230-6. PMID 12370353 DOI: 10.4049/Jimmunol.169.8.4230  0.451
2002 Wilcox RA, Flies DB, Wang H, Tamada K, Johnson AJ, Pease LR, Rodriguez M, Guo Y, Chen L. Impaired infiltration of tumor-specific cytolytic T cells in the absence of interferon-gamma despite their normal maturation in lymphoid organs during CD137 monoclonal antibody therapy. Cancer Research. 62: 4413-8. PMID 12154048  0.699
2002 Chapoval AI, Zhu G, Chen L. Immunoglobulin fusion proteins as a tool for evaluation of T-cell costimulatory molecules. Molecular Biotechnology. 21: 259-264. PMID 12102550 DOI: 10.1385/Mb:21:3:259  0.422
2002 Dong H, Strome SE, Salomao DR, Tamura H, Hirano F, Flies DB, Roche PC, Lu J, Zhu G, Tamada K, Lennon VA, Celis E, Chen L. Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nature Medicine. 8: 793-800. PMID 12091876 DOI: 10.1038/Nm730  0.774
2002 May KF, Chen L, Zheng P, Liu Y. Anti-4-1BB monoclonal antibody enhances rejection of large tumor burden by promoting survival but not clonal expansion of tumor-specific CD8+ T cells. Cancer Research. 62: 3459-65. PMID 12067989  0.378
2002 Hsu TL, Chang YC, Chen SJ, Liu YJ, Chiu AW, Chio CC, Chen L, Hsieh SL. Modulation of dendritic cell differentiation and maturation by decoy receptor 3. Journal of Immunology (Baltimore, Md. : 1950). 168: 4846-53. PMID 11994433 DOI: 10.4049/Jimmunol.168.10.4846  0.467
2002 Tamada K, Ni J, Zhu G, Fiscella M, Teng B, van Deursen JM, Chen L. Cutting edge: selective impairment of CD8+ T cell function in mice lacking the TNF superfamily member LIGHT. Journal of Immunology (Baltimore, Md. : 1950). 168: 4832-5. PMID 11994431 DOI: 10.4049/Jimmunol.168.10.4832  0.466
2002 Petroff MG, Chen L, Phillips TA, Hunt JS. B7 family molecules: novel immunomodulators at the maternal-fetal interface. Placenta. 23: S95-101. PMID 11978065 DOI: 10.1053/Plac.2002.0813  0.396
2002 Wilcox RA, Chapoval AI, Gorski KS, Otsuji M, Shin T, Flies DB, Tamada K, Mittler RS, Tsuchiya H, Pardoll DM, Chen L. Cutting edge: Expression of functional CD137 receptor by dendritic cells. Journal of Immunology (Baltimore, Md. : 1950). 168: 4262-7. PMID 11970964 DOI: 10.4049/Jimmunol.168.9.4262  0.736
2002 Wang S, Zhu G, Tamada K, Chen L, Bajorath J. Ligand binding sites of inducible costimulator and high avidity mutants with improved function. The Journal of Experimental Medicine. 195: 1033-41. PMID 11956294 DOI: 10.1084/Jem.20011607  0.384
2002 Chen L. Antibody gene therapy: Old wine in a new bottle Nature Medicine. 8: 333-334. PMID 11927934 DOI: 10.1038/Nm0402-333  0.387
2002 Strome SE, Voss S, Wilcox R, Wakefield TL, Tamada K, Flies D, Chapoval A, Lu J, Kasperbauer JL, Padley D, Vile R, Gastineau D, Wettstein P, Chen L. Strategies for antigen loading of dendritic cells to enhance the antitumor immune response. Cancer Research. 62: 1884-9. PMID 11912169  0.693
2002 Wilcox RA, Chen L. Immunotherapy of human papillomavirus-associated malignancies and the challenges posed by T-cell tolerance. Frontiers in Bioscience. 7. PMID 11897572 DOI: 10.2741/Wilcox  0.408
2002 Wilcox RA, Flies DB, Zhu G, Johnson AJ, Tamada K, Chapoval AI, Strome SE, Pease LR, Chen L. Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors. The Journal of Clinical Investigation. 109: 651-9. PMID 11877473 DOI: 10.1172/Jci14184  0.723
2002 Strome SE, Martin E, Flies D, Khurana D, Salomao D, Tamada K, Chapoval AI, Kasperbauer JL, Olsen KD, Chen L. Reassessment of CD62L as a marker of pre-effector T cells in the tumor draining lymph nodes of head and neck cancer patients. Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery. 126: 180-7. PMID 11870350 DOI: 10.1067/Mhn.2002.122263  0.705
2002 Tamada K, Tamura H, Flies D, Fu YX, Celis E, Pease LR, Blazar BR, Chen L. Blockade of LIGHT/LTbeta and CD40 signaling induces allospecific T cell anergy, preventing graft-versus-host disease. The Journal of Clinical Investigation. 109: 549-57. PMID 11854328 DOI: 10.1172/JCI13604  0.726
2002 Sun Y, Lin X, Chen HM, Wu Q, Subudhi SK, Chen L, Fu YX. Administration of agonistic anti-4-1BB monoclonal antibody leads to the amelioration of experimental autoimmune encephalomyelitis. Journal of Immunology (Baltimore, Md. : 1950). 168: 1457-65. PMID 11801689 DOI: 10.4049/Jimmunol.168.3.1457  0.478
2002 Sica G, Chen L. Modulation of the Immune Response Through 4-1BB Advances in Experimental Medicine and Biology. 465: 355-362. PMID 10810639 DOI: 10.1007/0-306-46817-4_30  0.308
2002 Tamada K, Tamura H, Flies D, Fu YX, Celis E, Pease LR, Blazar BR, Chen L. Blockade of LIGHT/LTβ and CD40 signaling induces allospecific T cell anergy, preventing graft-versus-host disease Journal of Clinical Investigation. 109: 549-557. DOI: 10.1172/Jci200213604  0.745
2001 Wang J, Lo JC, Foster A, Yu P, Chen HM, Wang Y, Tamada K, Chen L, Fu YX. The regulation of T cell homeostasis and autoimmunity by T cell-derived LIGHT. The Journal of Clinical Investigation. 108: 1771-80. PMID 11748260 DOI: 10.1172/Jci13827  0.448
2001 Wang J, Chun T, Lo JC, Wu Q, Wang Y, Foster A, Roca K, Chen M, Tamada K, Chen L, Wang CR, Fu YX. The critical role of LIGHT, a TNF family member, in T cell development. Journal of Immunology (Baltimore, Md. : 1950). 167: 5099-105. PMID 11673520 DOI: 10.4049/Jimmunol.167.9.5099  0.404
2001 Zhu G, Flies DB, Tamada K, Sun Y, Rodriguez M, Fu YX, Chen L. Progressive depletion of peripheral B lymphocytes in 4-1BB (CD137) ligand/I-Ealpha)-transgenic mice. Journal of Immunology (Baltimore, Md. : 1950). 167: 2671-6. PMID 11509610 DOI: 10.4049/Jimmunol.167.5.2671  0.747
2001 Sica GL, Zhu G, Tamada K, Liu D, Ni J, Chen L. RELT, a new member of the tumor necrosis factor receptor superfamily, is selectively expressed in hematopoietic tissues and activates transcription factor NF-kappaB. Blood. 97: 2702-7. PMID 11313261 DOI: 10.1182/Blood.V97.9.2702  0.403
2001 Tamura H, Dong H, Zhu G, Sica GL, Flies DB, Tamada K, Chen L. B7-H1 costimulation preferentially enhances CD28-independent T-helper cell function. Blood. 97: 1809-16. PMID 11238124 DOI: 10.1182/Blood.V97.6.1809  0.773
2001 Chapoval AI, Ni J, Lau JS, Wilcox RA, Flies DB, Liu D, Dong H, Sica GL, Zhu G, Tamada K, Chen L. B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production. Nature Immunology. 2: 269-74. PMID 11224528 DOI: 10.1038/85339  0.775
2000 Tamada K, Chen L. T lymphocyte costimulatory molecules in host defense and immunologic diseases. Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology. 85: 164-75; quiz 175-7. PMID 11030270 DOI: 10.1016/S1081-1206(10)62462-3  0.433
2000 Strome SE, Martin B, Flies D, Tamada K, Chapoval AI, Sargent DJ, Shu S, Chen L. Enhanced therapeutic potential of adoptive immunotherapy by in vitro CD28/4-1BB costimulation of tumor-reactive T cells against a poorly immunogenic, major histocompatibility complex class I-negative A9P melanoma. Journal of Immunotherapy (Hagerstown, Md. : 1997). 23: 430-7. PMID 10916752 DOI: 10.1097/00002371-200007000-00006  0.749
2000 Chen SH, Pham-Nguyen KB, Martinet O, Huang Y, Yang W, Thung SN, Chen L, Mittler R, Woo SL. Rejection of disseminated metastases of colon carcinoma by synergism of IL-12 gene therapy and 4-1BB costimulation. Molecular Therapy : the Journal of the American Society of Gene Therapy. 2: 39-46. PMID 10899826 DOI: 10.1006/Mthe.2000.0086  0.418
2000 Martinet O, Ermekova V, Qiao JQ, Sauter B, Mandeli J, Chen L, Chen SH. Immunomodulatory gene therapy with interleukin 12 and 4-1BB ligand: Long-term remission of liver metastases in a mouse model Journal of the National Cancer Institute. 92: 931-936. PMID 10841829 DOI: 10.1093/Jnci/92.11.931  0.448
2000 Tamada K, Shimozaki K, Chapoval AI, Zhai Y, Su J, Chen SF, Hsieh SL, Nagata S, Ni J, Chen L. LIGHT, a TNF-like molecule, costimulates T cell proliferation and is required for dendritic cell-mediated allogeneic T cell response. Journal of Immunology (Baltimore, Md. : 1950). 164: 4105-10. PMID 10754304 DOI: 10.4049/Jimmunol.164.8.4105  0.428
2000 Tamada K, Shimozaki K, Chapoval AI, Zhu G, Sica G, Flies D, Boone T, Hsu H, Fu YX, Nagata S, Ni J, Chen L. Modulation of T-cell-mediated immunity in tumor and graft-versus-host disease models through the LIGHT co-stimulatory pathway. Nature Medicine. 6: 283-9. PMID 10700230 DOI: 10.1038/73136  0.741
2000 Wang S, Zhu G, Chapoval AI, Dong H, Tamada K, Ni J, Chen L. Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS Blood. 96: 2808-2813. DOI: 10.1182/Blood.V96.8.2808  0.49
2000 Chapoval AI, Tamada K, Chen L. In vitro growth inhibition of a broad spectrum of tumor cell lines by activated human dendritic cells Blood. 95: 2346-2351. DOI: 10.1182/Blood.V95.7.2346.007K05_2346_2351  0.409
1999 Hu S, Tamada K, Ni J, Vincenz C, Chen L. Characterization of TNFRSF19, a novel member of the tumor necrosis factor receptor superfamily. Genomics. 62: 103-7. PMID 10585776 DOI: 10.1006/Geno.1999.5979  0.389
1999 Dong H, Zhu G, Tamada K, Chen L. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nature Medicine. 5: 1365-9. PMID 10581077 DOI: 10.1038/70932  0.513
1999 Chen L. Mimotopes of cytolytic T lymphocytes in cancer immunotherapy. Current Opinion in Immunology. 11: 219-222. PMID 10322156 DOI: 10.1016/S0952-7915(99)80037-5  0.376
1999 Johnson AJ, Njenga MK, Hansen MJ, Kuhns ST, Chen L, Rodriguez M, Pease LR. Prevalent class I-restricted T-cell response to the Theiler's virus epitope Db:VP2121-130 in the absence of endogenous CD4 help, tumor necrosis factor alpha, gamma interferon, perforin, or costimulation through CD28. Journal of Virology. 73: 3702-8. PMID 10196262 DOI: 10.1128/Jvi.73.5.3702-3708.1999  0.429
1998 Melero I, Johnston JV, Shufford WW, Mittler RS, Chen L. NK1.1 cells express 4-1BB (CDw137) costimulatory molecule and are required for tumor immunity elicited by anti-4-1BB monoclonal antibodies Cellular Immunology. 190: 167-172. PMID 9878117 DOI: 10.1006/Cimm.1998.1396  0.438
1998 Melero I, Bach N, Hellström KE, Aruffo A, Mittler RS, Chen L. Amplification of tumor immunity by gene transfer of the co-stimulatory 4-1BB ligand: Synergy with the CD28 co-stimulatory pathway European Journal of Immunology. 28: 1116-1121. PMID 9541607 DOI: 10.1002/(Sici)1521-4141(199803)28:03<1116::Aid-Immu1116>3.0.Co;2-A  0.532
1998 Chen L. Immunological ignorance of silent antigens as an explanation of tumor evasion Immunology Today. 19: 27-30. PMID 9465485 DOI: 10.1016/S0167-5699(97)01180-8  0.431
1997 Yang G, Hellström KE, Chen L. The role of B7-2 (CD86) in tumour immunity. Expert Opinion On Investigational Drugs. 6: 677-684. PMID 15989635 DOI: 10.1517/13543784.6.6.677  0.5
1997 Wick M, Dubey P, Koeppen H, Siegel CT, Fields PE, Chen L, Bluestone JA, Schreiber H. Antigenic cancer cells grow progressively in immune hosts without evidence for T cell exhaustion or systemic anergy. The Journal of Experimental Medicine. 186: 229-38. PMID 9221752 DOI: 10.1084/Jem.186.2.229  0.484
1997 Melero I, Bach N, Chen L. Costimulation, tolerance and ignorance of cytolytic T lymphocytes in immune responses to tumor antigens Life Sciences. 60: 2035-2041. PMID 9180357 DOI: 10.1016/S0024-3205(96)00686-8  0.488
1997 Melero I, Shuford WW, Newby SA, Aruffo A, Ledbetter JA, Hellström KE, Mittler RS, Chen L. Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors. Nature Medicine. 3: 682-5. PMID 9176498 DOI: 10.1038/Nm0697-682  0.523
1997 Melero I, Singhal MC, McGowan P, Haugen HS, Blake J, Hellstrom KE, Yang G, Clegg CH, Chen L. Immunological ignorance of an E7-encoded cytolytic T-lymphocyte epitope in transgenic mice expressing the E7 and E6 oncogenes of human papillomavirus type 16. Journal of Virology. 71: 3998-4004. PMID 9094677 DOI: 10.1128/Jvi.71.5.3998-4004.1997  0.314
1996 Hellström KE, Chen L, Hellström I. Costimulation of T-cell-mediated tumor immunity Cancer Chemotherapy and Pharmacology. 38. PMID 8765415 DOI: 10.1007/S002800051036  0.46
1996 Blake J, Johnston JV, Hellström KE, Marquardt H, Chen L. Use of combinatorial peptide libraries to construct functional mimics of tumor epitopes recognized by MHC class I-restricted cytolytic T lymphocytes. The Journal of Experimental Medicine. 184: 121-30. PMID 8691125 DOI: 10.1084/Jem.184.1.121  0.372
1996 Johnston JV, Malacko AR, Mizuno MT, McGowan P, Hellström I, Hellström KE, Marquardt H, Chen L. B7-CD28 costimulation unveils the hierarchy of tumor epitopes recognized by major histocompatibility complex class I-restricted CD8+ cytolytic T lymphocytes. The Journal of Experimental Medicine. 183: 791-800. PMID 8642283 DOI: 10.1084/Jem.183.3.791  0.528
1996 Li Y, Hellstrom KE, Newby SA, Chen L. Costimulation by CD48 and B7-1 induces immunity against poorly immunogenic tumors. The Journal of Experimental Medicine. 183: 639-44. PMID 8627175 DOI: 10.1084/Jem.183.2.639  0.498
1995 Hellström KE, Hellström I, Chen L. Can Co‐stimulated Tumor Immunity be Therapeutically Efficacious? Immunological Reviews. 145: 123-145. PMID 7590823 DOI: 10.1111/J.1600-065X.1995.Tb00079.X  0.344
1994 Zhang L, Hellström KE, Chen L. Luciferase activity as a marker of tumor burden and as an indicator of tumor response to antineoplastic therapy in vivo Clinical & Experimental Metastasis. 12: 87-92. PMID 8306531 DOI: 10.1007/Bf01753974  0.35
1994 Chen L, McGowan P, Ashe S, Johnston J, Li Y, Hellström I, Hellström KE. Tumor immunogenicity determines the effect of B7 costimulation on T cell-mediated tumor immunity Journal of Experimental Medicine. 179: 523-532. PMID 7507508 DOI: 10.1084/Jem.179.2.523  0.484
1993 Hellström KE, Hellström I, Linsley P, Chen L. On the Role of Costimulation in Tumor Immunity Annals of the New York Academy of Sciences. 690: 225-230. PMID 7690212 DOI: 10.1111/J.1749-6632.1993.Tb44011.X  0.355
1993 Chen L, Linsley PS, Hellström KE. Costimulation of T cells for tumor immunity Immunology Today. 14: 483-486. PMID 7506034 DOI: 10.1016/0167-5699(93)90262-J  0.498
1992 Chen L, Ashe S, Brady WA, Hellström I, Hellström KE, Ledbetter JA, McGowan P, Linsley PS. Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4 Cell. 71: 1093-1102. PMID 1335364 DOI: 10.1016/S0092-8674(05)80059-5  0.542
1991 Chen LP, Thomas EK, Hu SL, Hellström I, Hellström KE. Human papillomavirus type 16 nucleoprotein E7 is a tumor rejection antigen. Proceedings of the National Academy of Sciences of the United States of America. 88: 110-4. PMID 1846033 DOI: 10.1073/Pnas.88.1.110  0.322
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