Ramesh A. Shivdasani - Publications

Affiliations: 
Harvard University, Cambridge, MA, United States 
Area:
Cell Biology, Human Development

146 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Singh PNP, Gu W, Madha S, Lynch AW, Cejas P, He R, Bhattacharya S, Gomez MM, Oser MG, Brown M, Long HW, Meyer CA, Zhou Q, Shivdasani RA. Transcription factor dynamics, oscillation, and functions in human enteroendocrine cell differentiation. Biorxiv : the Preprint Server For Biology. PMID 38260422 DOI: 10.1101/2024.01.09.574746  0.33
2023 Kalra G, Lenz D, Abdul-Aziz D, Hanna C, Basu M, Herb BR, Colantuoni C, Milon B, Saxena M, Shetty AC, Hertzano R, Shivdasani RA, Ament SA, Edge ASB. Cochlear organoids reveal transcriptional programs of postnatal hair cell differentiation from supporting cells. Cell Reports. 42: 113421. PMID 37952154 DOI: 10.1016/j.celrep.2023.113421  0.311
2023 Kraiczy J, McCarthy N, Malagola E, Tie G, Madha S, Boffelli D, Wagner DE, Wang TC, Shivdasani RA. Graded BMP signaling within intestinal crypt architecture directs self-organization of the Wnt-secreting stem cell niche. Cell Stem Cell. 30: 433-449.e8. PMID 37028407 DOI: 10.1016/j.stem.2023.03.004  0.303
2021 Gu W, Wang H, Huang X, Kraiczy J, Singh PNP, Ng C, Dagdeviren S, Houghton S, Pellon-Cardenas O, Lan Y, Nie Y, Zhang J, Banerjee KK, Onufer EJ, Warner BW, ... ... Shivdasani RA, et al. SATB2 preserves colon stem cell identity and mediates ileum-colon conversion via enhancer remodeling. Cell Stem Cell. PMID 34582804 DOI: 10.1016/j.stem.2021.09.004  0.301
2020 McCarthy N, Kraiczy J, Shivdasani RA. Cellular and molecular architecture of the intestinal stem cell niche. Nature Cell Biology. 22: 1033-1041. PMID 32884148 DOI: 10.1038/S41556-020-0567-Z  0.418
2020 Verzi MP, Shivdasani RA. Epigenetic regulation of intestinal stem cell differentiation. American Journal of Physiology. Gastrointestinal and Liver Physiology. PMID 32628072 DOI: 10.1152/Ajpgi.00084.2020  0.443
2020 Rao-Bhatia A, Zhu M, Yin WC, Coquenlorge S, Zhang X, Woo J, Sun Y, Dean CH, Liu A, Hui CC, Shivdasani RA, McNeill H, Hopyan S, Kim TH. Hedgehog-Activated Fat4 and PCP Pathways Mediate Mesenchymal Cell Clustering and Villus Formation in Gut Development. Developmental Cell. 52: 647-658.e6. PMID 32155439 DOI: 10.1016/J.Devcel.2020.02.003  0.717
2020 Murata K, Jadhav U, Madha S, van Es J, Dean J, Cavazza A, Wucherpfennig K, Michor F, Clevers H, Shivdasani RA. Ascl2-Dependent Cell Dedifferentiation Drives Regeneration of Ablated Intestinal Stem Cells. Cell Stem Cell. PMID 32084390 DOI: 10.1016/J.Stem.2019.12.011  0.428
2020 McCarthy N, Manieri E, Storm EE, Saadatpour A, Luoma AM, Kapoor VN, Madha S, Gaynor LT, Cox C, Keerthivasan S, Wucherpfennig K, Yuan GC, de Sauvage FJ, Turley SJ, Shivdasani RA. Distinct Mesenchymal Cell Populations Generate the Essential Intestinal BMP Signaling Gradient. Cell Stem Cell. PMID 32084389 DOI: 10.1016/J.Stem.2020.01.008  0.4
2020 Jadhav U, Manieri E, Nalapareddy K, Madha S, Chakrabarti S, Wucherpfennig K, Barefoot M, Shivdasani RA. Replicational Dilution of H3K27me3 in Mammalian Cells and the Role of Poised Promoters. Molecular Cell. PMID 32027840 DOI: 10.1016/J.Molcel.2020.01.017  0.418
2019 Kim CK, Saxena M, Maharjan K, Song JJ, Shroyer KR, Bialkowska AB, Shivdasani RA, Yang VW. Krüppel-like factor 5 regulates stemness, lineage specification, and regeneration of intestinal epithelial stem cells. Cellular and Molecular Gastroenterology and Hepatology. PMID 31778829 DOI: 10.1016/J.Jcmgh.2019.11.009  0.453
2019 Cejas P, Drier Y, Dreijerink KMA, Brosens LAA, Deshpande V, Epstein CB, Conemans EB, Morsink FHM, Graham MK, Valk GD, Vriens MR, Castillo CF, Ferrone CR, Adar T, Bowden M, ... ... Shivdasani RA, et al. Enhancer signatures stratify and predict outcomes of non-functional pancreatic neuroendocrine tumors. Nature Medicine. PMID 31263286 DOI: 10.1038/S41591-019-0493-4  0.342
2019 Jadhav U, Cavazza A, Banerjee KK, Xie H, O'Neill NK, Saenz-Vash V, Herbert Z, Madha S, Orkin SH, Zhai H, Shivdasani RA. Extensive Recovery of Embryonic Enhancer and Gene Memory Stored in Hypomethylated Enhancer DNA. Molecular Cell. PMID 30905509 DOI: 10.1016/J.Molcel.2019.02.024  0.33
2019 Jadhav U, Shivdasani RA. Dissecting Cell Lineages: From Microscope to Kaleidoscope. Cell. 176: 949-951. PMID 30794779 DOI: 10.1016/J.Cell.2019.01.054  0.37
2019 Kumar N, Tsai YH, Chen L, Zhou A, Banerjee KK, Saxena M, Huang S, Toke NH, Xing J, Shivdasani RA, Spence JR, Verzi MP. The lineage-specific transcription factor CDX2 navigates dynamic chromatin to control distinct stages of intestine development. Development (Cambridge, England). PMID 30745430 DOI: 10.1242/Dev.172189  0.407
2018 Witwicki RM, Ekram MB, Qiu X, Janiszewska M, Shu S, Kwon M, Trinh A, Frias E, Ramadan N, Hoffman G, Yu K, Xie Y, McAllister G, McDonald R, Golji J, ... ... Shivdasani RA, et al. TRPS1 Is a Lineage-Specific Transcriptional Dependency in Breast Cancer. Cell Reports. 25: 1255-1267.e5. PMID 30380416 DOI: 10.1016/J.Celrep.2018.10.023  0.344
2018 Banerjee KK, Saxena M, Kumar N, Chen L, Cavazza A, Toke NH, O'Neill NK, Madha S, Jadhav U, Verzi MP, Shivdasani RA. Enhancer, transcriptional, and cell fate plasticity precedes intestinal determination during endoderm development. Genes & Development. PMID 30366903 DOI: 10.1101/Gad.318832.118  0.413
2018 Shivdasani RA. Limited gut cell repertoire for multiple hormones. Nature Cell Biology. 20: 865-867. PMID 30038256 DOI: 10.1038/S41556-018-0153-9  0.306
2018 Saxena M, San Roman AK, O'Neill NK, Sulahian R, Jadhav U, Shivdasani RA. Transcription factor-dependent 'anti-repressive' mammalian enhancers exclude H3K27me3 from extended genomic domains. Genes & Development. PMID 29321178 DOI: 10.1101/Gad.308536.117  0.417
2017 Jadhav U, Saxena M, O'Neill NK, Saadatpour A, Yuan GC, Herbert Z, Murata K, Shivdasani RA. Dynamic Reorganization of Chromatin Accessibility Signatures during Dedifferentiation of Secretory Precursors into Lgr5+ Intestinal Stem Cells. Cell Stem Cell. PMID 28648363 DOI: 10.1016/J.Stem.2017.05.001  0.403
2017 Yuan GC, Cai L, Elowitz M, Enver T, Fan G, Guo G, Irizarry R, Kharchenko P, Kim J, Orkin S, Quackenbush J, Saadatpour A, Schroeder T, Shivdasani R, Tirosh I. Challenges and emerging directions in single-cell analysis. Genome Biology. 18: 84. PMID 28482897 DOI: 10.1186/S13059-017-1218-Y  0.325
2017 Mathur R, Alver BH, Roman AKS, Wilson BG, Wang X, Agoston AT, Park P, Shivdasani R, Roberts CW. Abstract LB-286: ARID1A loss impairs enhancer-mediated gene regulation and drives colon cancer in mice Cancer Research. 77. DOI: 10.1158/1538-7445.Am2017-Lb-286  0.405
2016 Mathur R, Alver BH, San Roman AK, Wilson BG, Wang X, Agoston AT, Park PJ, Shivdasani RA, Roberts CW. ARID1A loss impairs enhancer-mediated gene regulation and drives colon cancer in mice. Nature Genetics. PMID 27941798 DOI: 10.1038/Ng.3744  0.409
2016 Cejas P, Cavazza A, Yandava C, Moreno V, Horst D, Moreno-Rubio J, Burgos E, Mendiola M, Taing L, Goel A, Feliu J, Shivdasani RA. Transcriptional regulator CNOT3 defines an aggressive colorectal cancer subtype. Cancer Research. PMID 27899379 DOI: 10.1158/0008-5472.Can-16-1346  0.432
2016 Kim TH, Saadatpour A, Guo G, Saxena M, Cavazza A, Desai N, Jadhav U, Jiang L, Rivera MN, Orkin SH, Yuan GC, Shivdasani RA. Single-Cell Transcript Profiles Reveal Multilineage Priming in Early Progenitors Derived from Lgr5(+) Intestinal Stem Cells. Cell Reports. PMID 27524622 DOI: 10.1016/J.Celrep.2016.07.056  0.439
2016 Sarkar A, Huebner AJ, Sulahian R, Anselmo A, Xu X, Flattery K, Desai N, Sebastian C, Yram MA, Arnold K, Rivera M, Mostoslavsky R, Bronson R, Bass AJ, Sadreyev R, ... Shivdasani RA, et al. Sox2 Suppresses Gastric Tumorigenesis in Mice. Cell Reports. PMID 27498859 DOI: 10.1016/J.Celrep.2016.07.034  0.432
2016 Zang C, Luyten A, Chen J, Liu XS, Shivdasani RA. NF-E2, FLI1 and RUNX1 collaborate at areas of dynamic chromatin to activate transcription in mature mouse megakaryocytes. Scientific Reports. 6: 30255. PMID 27457419 DOI: 10.1038/Srep30255  0.378
2016 Bertaux-Skeirik N, Centeno J, Feng R, Schumacher MA, Shivdasani RA, Zavros Y. Co-culture of Gastric Organoids and Immortalized Stomach Mesenchymal Cells. Methods in Molecular Biology (Clifton, N.J.). 1422: 23-31. PMID 27246019 DOI: 10.1007/978-1-4939-3603-8_3  0.319
2016 Jadhav U, Nalapareddy K, Saxena M, O'Neill NK, Pinello L, Yuan GC, Orkin SH, Shivdasani RA. Acquired Tissue-Specific Promoter Bivalency Is a Basis for PRC2 Necessity in Adult Cells. Cell. PMID 27212235 DOI: 10.1016/J.Cell.2016.04.031  0.401
2016 Ariyachet C, Tovaglieri A, Xiang G, Lu J, Shah MS, Richmond CA, Verbeke C, Melton DA, Stanger BZ, Mooney D, Shivdasani RA, Mahony S, Xia Q, Breault DT, Zhou Q. Reprogrammed Stomach Tissue as a Renewable Source of Functional β Cells for Blood Glucose Regulation. Cell Stem Cell. PMID 26908146 DOI: 10.1016/J.Stem.2016.01.003  0.355
2016 Kim TH, Shivdasani RA. Stomach development, stem cells and disease. Development (Cambridge, England). 143: 554-65. PMID 26884394 DOI: 10.1242/Dev.124891  0.414
2015 Sulahian R, Chen J, Arany Z, Jadhav U, Peng S, Rustgi AK, Bass AJ, Srivastava A, Hornick JL, Shivdasani RA. SOX15 governs transcription in human stratified epithelia and a subset of esophageal adenocarcinomas. Cellular and Molecular Gastroenterology and Hepatology. 1: 598-609.e6. PMID 26516633 DOI: 10.1016/J.Jcmgh.2015.07.009  0.407
2015 San Roman AK, Tovaglieri A, Breault DT, Shivdasani RA. Distinct Processes and Transcriptional Targets Underlie CDX2 Requirements in Intestinal Stem Cells and Differentiated Villus Cells. Stem Cell Reports. 5: 673-81. PMID 26489894 DOI: 10.1016/J.Stemcr.2015.09.006  0.469
2015 Jayewickreme CD, Shivdasani RA. Control of stomach smooth muscle development and intestinal rotation by transcription factor BARX1. Developmental Biology. 405: 21-32. PMID 26057579 DOI: 10.1016/J.Ydbio.2015.05.024  0.429
2015 Schumacher MA, Aihara E, Feng R, Engevik A, Shroyer NF, Ottemann KM, Worrell RT, Montrose MH, Shivdasani RA, Zavros Y. The use of murine-derived fundic organoids in studies of gastric physiology. The Journal of Physiology. 593: 1809-27. PMID 25605613 DOI: 10.1113/Jphysiol.2014.283028  0.371
2015 San Roman AK, Aronson BE, Krasinski SD, Shivdasani RA, Verzi MP. Transcription factors GATA4 and HNF4A control distinct aspects of intestinal homeostasis in conjunction with transcription factor CDX2. The Journal of Biological Chemistry. 290: 1850-60. PMID 25488664 DOI: 10.1074/Jbc.M114.620211  0.441
2014 Luyten A, Zang C, Liu XS, Shivdasani RA. Active enhancers are delineated de novo during hematopoiesis, with limited lineage fidelity among specified primary blood cells. Genes & Development. 28: 1827-39. PMID 25128499 DOI: 10.1101/Gad.240101.114  0.433
2014 Morris SA, Cahan P, Li H, Zhao AM, San Roman AK, Shivdasani RA, Collins JJ, Daley GQ. Dissecting engineered cell types and enhancing cell fate conversion via CellNet. Cell. 158: 889-902. PMID 25126792 DOI: 10.1016/J.Cell.2014.07.021  0.381
2014 Feng R, Aihara E, Kenny S, Yang L, Li J, Varro A, Montrose MH, Shroyer NF, Wang TC, Shivdasani RA, Zavros Y. Indian Hedgehog mediates gastrin-induced proliferation in stomach of adult mice. Gastroenterology. 147: 655-666.e9. PMID 24859162 DOI: 10.1053/J.Gastro.2014.05.006  0.376
2014 San Roman AK, Jayewickreme CD, Murtaugh LC, Shivdasani RA. Wnt secretion from epithelial cells and subepithelial myofibroblasts is not required in the mouse intestinal stem cell niche in vivo. Stem Cell Reports. 2: 127-34. PMID 24527386 DOI: 10.1016/J.Stemcr.2013.12.012  0.426
2014 Shivdasani RA. Radiation redux: reserve intestinal stem cells miss the call to duty. Cell Stem Cell. 14: 135-6. PMID 24506878 DOI: 10.1016/J.Stem.2014.01.015  0.339
2014 Kim TH, Li F, Ferreiro-Neira I, Ho LL, Luyten A, Nalapareddy K, Long H, Verzi M, Shivdasani RA. Broadly permissive intestinal chromatin underlies lateral inhibition and cell plasticity. Nature. 506: 511-5. PMID 24413398 DOI: 10.1038/Nature12903  0.458
2014 Sulahian R, Casey F, Shen J, Qian ZR, Shin H, Ogino S, Weir BA, Vazquez F, Liu XS, Hahn WC, Bass AJ, Chan V, Shivdasani RA. An integrative analysis reveals functional targets of GATA6 transcriptional regulation in gastric cancer. Oncogene. 33: 5637-48. PMID 24317510 DOI: 10.1038/Onc.2013.517  0.413
2014 Verzi MP, Shin H, San Roman AK, Liu XS, Shivdasani RA. Erratum for Verzi et al., Intestinal Master Transcription Factor CDX2 Controls Chromatin Access for Partner Transcription Factor Binding Molecular and Cellular Biology. 35: 496-496. DOI: 10.1128/Mcb.01396-14  0.303
2013 Pignon JC, Grisanzio C, Geng Y, Song J, Shivdasani RA, Signoretti S. p63-expressing cells are the stem cells of developing prostate, bladder, and colorectal epithelia. Proceedings of the National Academy of Sciences of the United States of America. 110: 8105-10. PMID 23620512 DOI: 10.1073/Pnas.1221216110  0.413
2013 Ho LL, Sinha A, Verzi M, Bernt KM, Armstrong SA, Shivdasani RA. DOT1L-mediated H3K79 methylation in chromatin is dispensable for Wnt pathway-specific and other intestinal epithelial functions. Molecular and Cellular Biology. 33: 1735-45. PMID 23428873 DOI: 10.1128/Mcb.01463-12  0.414
2013 Lobo GP, Amengual J, Baus D, Shivdasani RA, Taylor D, von Lintig J. Genetics and diet regulate vitamin A production via the homeobox transcription factor ISX. The Journal of Biological Chemistry. 288: 9017-27. PMID 23393141 DOI: 10.1074/Jbc.M112.444240  0.323
2013 Verzi MP, Shin H, San Roman AK, Liu XS, Shivdasani RA. Intestinal master transcription factor CDX2 controls chromatin access for partner transcription factor binding. Molecular and Cellular Biology. 33: 281-92. PMID 23129810 DOI: 10.1128/Mcb.01185-12  0.417
2012 Takada K, Zhu D, Bird GH, Sukhdeo K, Zhao JJ, Mani M, Lemieux M, Carrasco DE, Ryan J, Horst D, Fulciniti M, Munshi NC, Xu W, Kung AL, Shivdasani RA, et al. Targeted disruption of the BCL9/β-catenin complex inhibits oncogenic Wnt signaling. Science Translational Medicine. 4: 148ra117. PMID 22914623 DOI: 10.1126/Scitranslmed.3003808  0.33
2012 Kim TH, Shivdasani RA. Stem cell niches: famished Paneth cells, gluttonous stem cells. Current Biology : Cb. 22: R579-80. PMID 22835795 DOI: 10.1016/J.Cub.2012.06.017  0.37
2012 Dulak AM, Schumacher SE, van Lieshout J, Imamura Y, Fox C, Shim B, Ramos AH, Saksena G, Baca SC, Baselga J, Tabernero J, Barretina J, Enzinger PC, Corso G, Roviello F, ... ... Shivdasani RA, et al. Gastrointestinal adenocarcinomas of the esophagus, stomach, and colon exhibit distinct patterns of genome instability and oncogenesis. Cancer Research. 72: 4383-93. PMID 22751462 DOI: 10.1158/0008-5472.Can-11-3893  0.335
2012 Shivdasani RA. GEFs on the RhoAd to a colossal nucleus. Developmental Cell. 22: 471-2. PMID 22421037 DOI: 10.1016/J.Devcel.2012.02.010  0.324
2012 Kim TH, Escudero S, Shivdasani RA. Intact function of Lgr5 receptor-expressing intestinal stem cells in the absence of Paneth cells. Proceedings of the National Academy of Sciences of the United States of America. 109: 3932-7. PMID 22355124 DOI: 10.1073/Pnas.1113890109  0.414
2012 Horst D, Chen J, Morikawa T, Ogino S, Kirchner T, Shivdasani RA. Differential WNT activity in colorectal cancer confers limited tumorigenic potential and is regulated by MAPK signaling. Cancer Research. 72: 1547-56. PMID 22318865 DOI: 10.1158/0008-5472.Can-11-3222  0.394
2012 Ho Sui SJ, Begley K, Reilly D, Chapman B, McGovern R, Rocca-Sera P, Maguire E, Altschuler GM, Hansen TA, Sompallae R, Krivtsov A, Shivdasani RA, Armstrong SA, Culhane AC, Correll M, et al. The Stem Cell Discovery Engine: an integrated repository and analysis system for cancer stem cell comparisons. Nucleic Acids Research. 40: D984-91. PMID 22121217 DOI: 10.1093/Nar/Gkr1051  0.372
2012 Woo J, Teppei M, Ogino S, Shivdasani RA. Abstract PR2: Stroma-derived matrix metalloproteinase 9 (MMP9) confers resistance to anti-EGFR therapy through cell-extrinsic activation of ERBB2/ERK/JUN pathway Clinical Cancer Research. 18: PR2-PR2. DOI: 10.1158/1078-0432.Mechres-Pr2  0.674
2011 Yonesaka K, Zejnullahu K, Okamoto I, Satoh T, Cappuzzo F, Souglakos J, Ercan D, Rogers A, Roncalli M, Takeda M, Fujisaka Y, Philips J, Shimizu T, Maenishi O, Cho Y, ... ... Shivdasani RA, et al. Activation of ERBB2 signaling causes resistance to the EGFR-directed therapeutic antibody cetuximab. Science Translational Medicine. 3: 99ra86. PMID 21900593 DOI: 10.1126/Scitranslmed.3002442  0.309
2011 San Roman AK, Shivdasani RA. Boundaries, junctions and transitions in the gastrointestinal tract. Experimental Cell Research. 317: 2711-8. PMID 21802415 DOI: 10.1016/J.Yexcr.2011.07.011  0.355
2011 Woo J, Miletich I, Kim BM, Sharpe PT, Shivdasani RA. Barx1-mediated inhibition of Wnt signaling in the mouse thoracic foregut controls tracheo-esophageal septation and epithelial differentiation. Plos One. 6: e22493. PMID 21799872 DOI: 10.1371/Journal.Pone.0022493  0.725
2011 Kim TH, Kim BM, Mao J, Rowan S, Shivdasani RA. Endodermal Hedgehog signals modulate Notch pathway activity in the developing digestive tract mesenchyme. Development (Cambridge, England). 138: 3225-33. PMID 21750033 DOI: 10.1242/Dev.066233  0.41
2011 Zhang J, Roberts TM, Shivdasani RA. Targeting PI3K signaling as a therapeutic approach for colorectal cancer. Gastroenterology. 141: 50-61. PMID 21723986 DOI: 10.1053/J.Gastro.2011.05.010  0.315
2011 Verzi MP, Shin H, Ho LL, Liu XS, Shivdasani RA. Essential and redundant functions of caudal family proteins in activating adult intestinal genes. Molecular and Cellular Biology. 31: 2026-39. PMID 21402776 DOI: 10.1128/Mcb.01250-10  0.438
2011 Kim TH, Shivdasani RA. Notch signaling in stomach epithelial stem cell homeostasis Journal of Experimental Medicine. 208: 677-688. PMID 21402740 DOI: 10.1084/Jem.20101737  0.416
2011 Kim BM, Woo J, Kanellopoulou C, Shivdasani RA. Regulation of mouse stomach development and Barx1 expression by specific microRNAs. Development (Cambridge, England). 138: 1081-6. PMID 21307095 DOI: 10.1242/Dev.056317  0.675
2011 Kim TH, Shivdasani RA. Genetic evidence that intestinal Notch functions vary regionally and operate through a common mechanism of math1 repression Journal of Biological Chemistry. 286: 11427-11433. PMID 21282114 DOI: 10.1074/Jbc.M110.188797  0.472
2011 Mills JC, Shivdasani RA. Gastric epithelial stem cells Gastroenterology. 140: 412-424. PMID 21144849 DOI: 10.1053/J.Gastro.2010.12.001  0.398
2011 Horst D, Shivdasani RA. Abstract 5205: Selectively high Wnt pathway activity in subpopulations of colon cancer cells and its significance for tumor initiation Cancer Research. 71: 5205-5205. DOI: 10.1158/1538-7445.Am2011-5205  0.406
2011 Woo J, Morikawa T, Ogino S, Gilliland DG, Shivdasani RA. Abstract 3106: Intestinal mesenchymal fibroblasts promote early epithelial tumorigenesis through activation of integrin beta4 and receptor tyrosine kinases, bypassing common mutational mechanisms Cellular and Molecular Biology. 71: 3106-3106. DOI: 10.1158/1538-7445.Am2011-3106  0.683
2010 Verzi MP, Shin H, He HH, Sulahian R, Meyer CA, Montgomery RK, Fleet JC, Brown M, Liu XS, Shivdasani RA. Differentiation-specific histone modifications reveal dynamic chromatin interactions and partners for the intestinal transcription factor CDX2. Developmental Cell. 19: 713-26. PMID 21074721 DOI: 10.1016/J.Devcel.2010.10.006  0.463
2010 Verzi MP, Shivdasani RA. Stem cells: The intestinal-crypt casino. Nature. 467: 1055-6. PMID 20981089 DOI: 10.1038/4671055A  0.357
2010 Horst D, Gu X, Bhasin M, Yang Q, Verzi M, Lin D, Joseph M, Zhang X, Chen W, Li YP, Shivdasani RA, Libermann TA. Requirement of the epithelium-specific Ets transcription factor Spdef for mucous gland cell function in the gastric antrum Journal of Biological Chemistry. 285: 35047-35055. PMID 20801882 DOI: 10.1074/Jbc.M110.164541  0.456
2010 Verzi MP, Hatzis P, Sulahian R, Philips J, Schuijers J, Shin H, Freed E, Lynch JP, Dang DT, Brown M, Clevers H, Liu XS, Shivdasani RA. TCF4 and CDX2, major transcription factors for intestinal function, converge on the same cis-regulatory regions. Proceedings of the National Academy of Sciences of the United States of America. 107: 15157-62. PMID 20696899 DOI: 10.1073/Pnas.1003822107  0.414
2010 Mao J, Kim BM, Rajurkar M, Shivdasani RA, McMahon AP. Hedgehog signaling controls mesenchymal growth in the developing mammalian digestive tract. Development (Cambridge, England). 137: 1721-9. PMID 20430747 DOI: 10.1242/Dev.044586  0.386
2009 Bass AJ, Watanabe H, Mermel CH, Yu S, Perner S, Verhaak RG, Kim SY, Wardwell L, Tamayo P, Gat-Viks I, Ramos AH, Woo MS, Weir BA, Getz G, Beroukhim R, ... ... Shivdasani RA, et al. SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas. Nature Genetics. 41: 1238-42. PMID 19801978 DOI: 10.1038/Ng.465  0.395
2009 Kunert S, Meyer I, Fleischhauer S, Wannack M, Fiedler J, Shivdasani RA, Schulze H. The microtubule modulator RanBP10 plays a critical role in regulation of platelet discoid shape and degranulation. Blood. 114: 5532-40. PMID 19801445 DOI: 10.1182/Blood-2009-04-216804  0.343
2009 Chen Z, Shivdasani RA. Regulation of platelet biogenesis: insights from the May-Hegglin anomaly and other MYH9-related disorders. Journal of Thrombosis and Haemostasis : Jth. 272-6. PMID 19630815 DOI: 10.1111/J.1538-7836.2009.03425.X  0.341
2009 Montgomery RK, Shivdasani RA. Prominin1 (CD133) as an intestinal stem cell marker: promise and nuance. Gastroenterology. 136: 2051-4. PMID 19409288 DOI: 10.1053/J.Gastro.2009.04.021  0.3
2009 Wuelling M, Kaiser FJ, Buelens LA, Braunholz D, Shivdasani RA, Depping R, Vortkamp A. Trps1, a regulator of chondrocyte proliferation and differentiation, interacts with the activator form of Gli3. Developmental Biology. 328: 40-53. PMID 19389374 DOI: 10.1016/J.Ydbio.2009.01.012  0.403
2009 Verzi MP, Stanfel MN, Moses KA, Kim BM, Zhang Y, Schwartz RJ, Shivdasani RA, Zimmer WE. Role of the homeodomain transcription factor Bapx1 in mouse distal stomach development. Gastroenterology. 136: 1701-10. PMID 19208343 DOI: 10.1053/J.Gastro.2009.01.009  0.397
2009 Eeckhoute J, Lupien M, Meyer CA, Verzi MP, Shivdasani RA, Liu XS, Brown M. Cell-type selective chromatin remodeling defines the active subset of FOXA1-bound enhancers. Genome Research. 19: 372-80. PMID 19129543 DOI: 10.1101/Gr.084582.108  0.379
2008 Verzi MP, Shivdasani RA. Wnt signaling in gut organogenesis. Organogenesis. 4: 87-91. PMID 19279719 DOI: 10.4161/Org.4.2.5854  0.363
2008 Kantaputra P, Miletich I, Lüdecke HJ, Suzuki EY, Praphanphoj V, Shivdasani R, Wuelling M, Vortkamp A, Napierala D, Sharpe PT. Tricho-rhino-phalangeal syndrome with supernumerary teeth. Journal of Dental Research. 87: 1027-31. PMID 18946009 DOI: 10.1177/154405910808701102  0.337
2008 Firestein R, Bass AJ, Kim SY, Dunn IF, Silver SJ, Guney I, Freed E, Ligon AH, Vena N, Ogino S, Chheda MG, Tamayo P, Finn S, Shrestha Y, Boehm JS, ... ... Shivdasani RA, et al. CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity. Nature. 455: 547-51. PMID 18794900 DOI: 10.1038/Nature07179  0.343
2008 Hafler BP, Choi MY, Shivdasani RA, Rowitch DH. Expression and function of Nkx6.3 in vertebrate hindbrain Brain Research. 1222: 42-50. PMID 18586225 DOI: 10.1016/J.Brainres.2008.04.072  0.406
2008 Verzi MP, Khan AH, Ito S, Shivdasani RA. Transcription factor foxq1 controls mucin gene expression and granule content in mouse stomach surface mucous cells. Gastroenterology. 135: 591-600. PMID 18558092 DOI: 10.1053/J.Gastro.2008.04.019  0.441
2008 Napierala D, Sam K, Morello R, Zheng Q, Munivez E, Shivdasani RA, Lee B. Uncoupling of chondrocyte differentiation and perichondrial mineralization underlies the skeletal dysplasia in tricho-rhino-phalangeal syndrome. Human Molecular Genetics. 17: 2244-54. PMID 18424451 DOI: 10.1093/Hmg/Ddn125  0.384
2008 Choi MY, Romer AI, Wang Y, Wu MP, Ito S, Leiter AB, Shivdasani RA. Requirement of the tissue-restricted homeodomain transcription factor Nkx6.3 in differentiation of gastrin-producing G cells in the stomach antrum. Molecular and Cellular Biology. 28: 3208-18. PMID 18347062 DOI: 10.1128/Mcb.01737-07  0.435
2008 Schulze H, Dose M, Korpal M, Meyer I, Italiano JE, Shivdasani RA. RanBP10 is a cytoplasmic guanine nucleotide exchange factor that modulates noncentrosomal microtubules. The Journal of Biological Chemistry. 283: 14109-19. PMID 18347012 DOI: 10.1074/Jbc.M709397200  0.334
2008 Huang G, Zhang P, Hirai H, Elf S, Yan X, Chen Z, Koschmieder S, Okuno Y, Dayaram T, Growney JD, Shivdasani RA, Gilliland DG, Speck NA, Nimer SD, Tenen DG. PU.1 is a major downstream target of AML1 (RUNX1) in adult mouse hematopoiesis. Nature Genetics. 40: 51-60. PMID 17994017 DOI: 10.1038/Ng.2007.7  0.41
2007 Van Dyck F, Braem CV, Chen Z, Declercq J, Deckers R, Kim BM, Ito S, Wu MK, Cohen DE, Dewerchin M, Derua R, Waelkens E, Fiette L, Roebroek A, Schuit F, ... ... Shivdasani RA, et al. Loss of the PlagL2 Transcription Factor Affects Lacteal Uptake of Chylomicrons Cell Metabolism. 6: 406-413. PMID 17983586 DOI: 10.1016/J.Cmet.2007.09.010  0.311
2007 Junt T, Schulze H, Chen Z, Massberg S, Goerge T, Krueger A, Wagner DD, Graf T, Italiano JE, Shivdasani RA, von Andrian UH. Dynamic visualization of thrombopoiesis within bone marrow. Science (New York, N.Y.). 317: 1767-70. PMID 17885137 DOI: 10.1126/Science.1146304  0.304
2007 Kim BM, Miletich I, Mao J, McMahon AP, Sharpe PA, Shivdasani RA. Independent functions and mechanisms for homeobox gene Barx1 in patterning mouse stomach and spleen. Development (Cambridge, England). 134: 3603-13. PMID 17855428 DOI: 10.1242/Dev.009308  0.447
2007 Kim BM, Mao J, Taketo MM, Shivdasani RA. Phases of canonical Wnt signaling during the development of mouse intestinal epithelium. Gastroenterology. 133: 529-38. PMID 17681174 DOI: 10.1053/J.Gastro.2007.04.072  0.364
2007 Chen Z, Naveiras O, Balduini A, Mammoto A, Conti MA, Adelstein RS, Ingber D, Daley GQ, Shivdasani RA. The May-Hegglin anomaly gene MYH9 is a negative regulator of platelet biogenesis modulated by the Rho-ROCK pathway. Blood. 110: 171-9. PMID 17392504 DOI: 10.1182/Blood-2007-02-071589  0.416
2007 Chen Z, Hu M, Shivdasani RA. Expression analysis of primary mouse megakaryocyte differentiation and its application in identifying stage-specific molecular markers and a novel transcriptional target of NF-E2. Blood. 109: 1451-9. PMID 17047147 DOI: 10.1182/Blood-2006-08-038901  0.422
2006 Choi MY, Romer AI, Hu M, Lepourcelet M, Mechoor A, Yesilaltay A, Krieger M, Gray PA, Shivdasani RA. A dynamic expression survey identifies transcription factors relevant in mouse digestive tract development. Development (Cambridge, England). 133: 4119-29. PMID 16971476 DOI: 10.1242/Dev.02537  0.418
2006 Chen Z, Balduini A, Conti MA, Adelstein RS, Shivdasani RA. Loss of Non-Muscle Myosin Heavy Chain IIA Function Does Not Restrict Megakaryocyte Maturation or Spontaneous Platelet Release and Likely Affects Non-Cell-Autonomous Aspects of Thrombopoiesis. Blood. 108: 701-701. DOI: 10.1182/Blood.V108.11.701.701  0.409
2005 Shivdasani RA, Schulze H. Culture, expansion, and differentiation of murine megakaryocytes. Current Protocols in Immunology / Edited by John E. Coligan ... [Et Al.]. Unit 22F.6. PMID 18432953 DOI: 10.1002/0471142735.Im22F06S67  0.361
2005 Hu M, Shivdasani RA. Overlapping gene expression in fetal mouse intestine development and human colorectal cancer. Cancer Research. 65: 8715-22. PMID 16204040 DOI: 10.1158/0008-5472.Can-05-0700  0.386
2005 Schulze H, Shivdasani RA. Mechanisms of thrombopoiesis. Journal of Thrombosis and Haemostasis : Jth. 3: 1717-24. PMID 16102038 DOI: 10.1111/J.1538-7836.2005.01426.X  0.399
2005 Kim BM, Buchner G, Miletich I, Sharpe PT, Shivdasani RA. The stomach mesenchymal transcription factor Barx1 specifies gastric epithelial identity through inhibition of transient Wnt signaling. Developmental Cell. 8: 611-22. PMID 15809042 DOI: 10.1016/J.Devcel.2005.01.015  0.452
2005 Drori S, Girnun GD, Tou L, Szwaya JD, Mueller E, Xia K, Kia X, Shivdasani RA, Spiegelman BM. Hic-5 regulates an epithelial program mediated by PPARgamma. Genes & Development. 19: 362-75. PMID 15687259 DOI: 10.1101/Gad.1240705  0.454
2005 Lepourcelet M, Tou L, Cai L, Sawada J, Lazar AJ, Glickman JN, Williamson JA, Everett AD, Redston M, Fox EA, Nakatani Y, Shivdasani RA. Insights into developmental mechanisms and cancers in the mammalian intestine derived from serial analysis of gene expression and study of the hepatoma-derived growth factor (HDGF). Development (Cambridge, England). 132: 415-27. PMID 15604097 DOI: 10.1242/Dev.01579  0.447
2005 Schulze H, Dose M, Korpal M, Italiano JE, Shivdasani RA. RanBP10 Is a Cytoplasmic GDP/GTP Exchange Factor That Modulates Microtubule Dynamics in Late Megakaryocytes. Blood. 106: 738-738. DOI: 10.1182/Blood.V106.11.738.738  0.311
2005 Schulze H, Korpal M, Hurov J, Kim S, Zhang J, Cantley LC, Graf T, Shivdasani RA. Phosphatidyl Inositol (4,5)P2 Marks Megakaryocyte Internal Membranes and Is Associated with Megakaryocyte Maturation and Platelet Release. Blood. 106: 732-732. DOI: 10.1182/Blood.V106.11.732.732  0.308
2005 Shivdasani RA. A Fli in the ointment Blood. 105: 9-10. DOI: 10.1182/Blood-2004-10-3862  0.33
2004 Schulze H, Shivdasani RA. Molecular mechanisms of megakaryocyte differentiation. Seminars in Thrombosis and Hemostasis. 30: 389-98. PMID 15354260 DOI: 10.1055/S-2004-833474  0.418
2004 Schulze H, Korpal M, Bergmeier W, Italiano JE, Wahl SM, Shivdasani RA. Interactions between the megakaryocyte/platelet-specific beta1 tubulin and the secretory leukocyte protease inhibitor SLPI suggest a role for regulated proteolysis in platelet functions. Blood. 104: 3949-57. PMID 15315966 DOI: 10.1182/Blood-2004-03-1179  0.323
2004 Shivdasani RA. Lonely in Paris: when one gene copy isn't enough. The Journal of Clinical Investigation. 114: 17-9. PMID 15232606 DOI: 10.1172/Jci22292  0.358
2004 Derjuga A, Gourley TS, Holm TM, Heng HH, Shivdasani RA, Ahmed R, Andrews NC, Blank V. Complexity of CNC transcription factors as revealed by gene targeting of the Nrf3 locus. Molecular and Cellular Biology. 24: 3286-94. PMID 15060151 DOI: 10.1128/Mcb.24.8.3286-3294.2004  0.356
2004 Tou L, Liu Q, Shivdasani RA. Regulation of mammalian epithelial differentiation and intestine development by class I histone deacetylases. Molecular and Cellular Biology. 24: 3132-9. PMID 15060137 DOI: 10.1128/Mcb.24.8.3132-3139.2004  0.393
2004 Lepourcelet M, Chen YNP, France DS, Wang H, Crews P, Petersen F, Bruseo C, Wood AW, Shivdasani RA. Small-molecule antagonists of the oncogenic Tcf/β-catenin protein complex Cancer Cell. 5: 91-102. PMID 14749129 DOI: 10.1016/S1535-6108(03)00334-9  0.325
2004 Italiano JE, Shivdasani RA. Megakaryocytes and beyond: the birth of platelets. Journal of Thrombosis and Haemostasis : Jth. 1: 1174-82. PMID 12871316 DOI: 10.1046/J.1538-7836.2003.00290.X  0.366
2003 Tiwari S, Italiano JE, Barral DC, Mules EH, Novak EK, Swank RT, Seabra MC, Shivdasani RA. A role for Rab27b in NF-E2-dependent pathways of platelet formation. Blood. 102: 3970-9. PMID 12907454 DOI: 10.1182/Blood-2003-03-0977  0.37
2002 Malik TH, Von Stechow D, Bronson RT, Shivdasani RA. Deletion of the GATA domain of TRPS1 causes an absence of facial hair and provides new insights into the bone disorder in inherited tricho-rhino-phalangeal syndromes. Molecular and Cellular Biology. 22: 8592-600. PMID 12446778 DOI: 10.1128/Mcb.22.24.8592-8600.2002  0.339
2002 Lepourcelet M, Shivdasani RA. Characterization of a novel mammalian Groucho isoform and its role in transcriptional regulation. The Journal of Biological Chemistry. 277: 47732-40. PMID 12359720 DOI: 10.1074/Jbc.M208154200  0.412
2002 Shivdasani RA. Molecular regulation of vertebrate early endoderm development. Developmental Biology. 249: 191-203. PMID 12221001 DOI: 10.1006/Dbio.2002.0765  0.405
2001 Poy F, Lepourcelet M, Shivdasani RA, Eck MJ. Structure of a human Tcf4-beta-catenin complex. Nature Structural Biology. 8: 1053-7. PMID 11713476 DOI: 10.1038/Nsb720  0.306
2001 Shivdasani RA. Molecular and transcriptional regulation of megakaryocyte differentiation. Stem Cells (Dayton, Ohio). 19: 397-407. PMID 11553848 DOI: 10.1634/Stemcells.19-5-397  0.424
2001 Schwer HD, Lecine P, Tiwari S, Italiano JE, Hartwig JH, Shivdasani RA. A lineage-restricted and divergent beta-tubulin isoform is essential for the biogenesis, structure and function of blood platelets. Current Biology : Cb. 11: 579-86. PMID 11369202 DOI: 10.1016/S0960-9822(01)00153-1  0.316
2001 Malik TH, Shoichet SA, Latham P, Kroll TG, Peters LL, Shivdasani RA. Transcriptional repression and developmental functions of the atypical vertebrate GATA protein TRPS1. The Embo Journal. 20: 1715-25. PMID 11285235 DOI: 10.1093/Emboj/20.7.1715  0.369
2001 Zhang J, Rosenthal A, de Sauvage FJ, Shivdasani RA. Downregulation of Hedgehog signaling is required for organogenesis of the small intestine in Xenopus. Developmental Biology. 229: 188-202. PMID 11133163 DOI: 10.1006/Dbio.2000.9953  0.416
2001 Li YJ, Higgins RR, Pak BJ, Shivdasani RA, Ney PA, Archer M, Ben-David Y. p45(NFE2) is a negative regulator of erythroid proliferation which contributes to the progression of Friend virus-induced erythroleukemias. Molecular and Cellular Biology. 21: 73-80. PMID 11113182 DOI: 10.1128/Mcb.21.1.73-80.2001  0.374
2000 Shivdasani RA. The role of transcription factor NF-E2 in megakaryocyte maturation and platelet production. Stem Cells (Dayton, Ohio). 112-5. PMID 11012210 DOI: 10.1002/Stem.5530140714  0.411
2000 Lecine P, Shivdasani RA. Cellular and molecular biology of megakaryocyte differentiation in the absence of lineage-restricted transcription factors. Stem Cells (Dayton, Ohio). 91-5. PMID 11012181 DOI: 10.1002/Stem.5530160712  0.426
2000 Malik TH, Shivdasani RA. Structure and expression of a novel frizzled gene isolated from the developing mouse gut Biochemical Journal. 349: 829-834. PMID 10903145 DOI: 10.1042/Bj3490829  0.395
2000 Shoichet SA, Malik TH, Rothman JH, Shivdasani RA. Action of the Caenorhabditis elegans GATA factor END-1 in Xenopus suggests that similar mechanisms initiate endoderm development in ecdysozoa and vertebrates. Proceedings of the National Academy of Sciences of the United States of America. 97: 4076-81. PMID 10760276 DOI: 10.1073/Pnas.97.8.4076  0.425
2000 Lecine P, Italiano JE, Kim S, Villeval J, Shivdasani RA. Hematopoietic-specific β1 tubulin participates in a pathway of platelet biogenesis dependent on the transcription factor NF-E2 Blood. 96: 1366-1373. DOI: 10.1182/Blood.V96.4.1366.H8001366_1366_1373  0.369
1999 Lee YJ, Swencki B, Shoichet S, Shivdasani RA. A possible role for the high mobility group box transcription factor Tcf-4 in vertebrate gut epithelial cell differentiation. The Journal of Biological Chemistry. 274: 1566-72. PMID 9880534 DOI: 10.1074/Jbc.274.3.1566  0.437
1999 Levin J, Peng J, Baker GR, Villeval J, Lecine P, Burstein SA, Shivdasani RA. Pathophysiology of Thrombocytopenia and Anemia in Mice Lacking Transcription Factor NF-E2 Blood. 94: 3037-3047. DOI: 10.1182/Blood.V94.9.3037  0.366
1999 Vyas P, Ault K, Jackson CW, Orkin SH, Shivdasani RA. Consequences of GATA-1 Deficiency in Megakaryocytes and Platelets Blood. 93: 2867-2875. DOI: 10.1182/Blood.V93.9.2867.409K24_2867_2875  0.401
1998 Orkin SH, Shivdasani RA, Fujiwara Y, McDevitt MA. Transcription factor GATA-1 in megakaryocyte development Stem Cells (Dayton, Ohio). 16: 79-83. PMID 11012179 DOI: 10.1002/Stem.5530160710  0.431
1998 Lecine P, Blank V, Shivdasani R. Characterization of the hematopoietic transcription factor NF-E2 in primary murine megakaryocytes. The Journal of Biological Chemistry. 273: 7572-8. PMID 9516460 DOI: 10.1074/Jbc.273.13.7572  0.372
1998 Shivdasani RA. Stem cell transcription factors. Hematology/Oncology Clinics of North America. 11: 1199-206. PMID 9443052 DOI: 10.1016/S0889-8588(05)70489-5  0.419
1998 Lecine P, Villeval J, Vyas P, Swencki B, Xu Y, Shivdasani RA. Mice Lacking Transcription Factor NF-E2 Provide In Vivo Validation of the Proplatelet Model of Thrombocytopoiesis and Show a Platelet Production Defect That Is Intrinsic to Megakaryocytes Blood. 92: 1608-1616. DOI: 10.1182/Blood.V92.5.1608.417K27_1608_1616  0.389
1998 Martin F, van Deursen JM, Shivdasani RA, Jackson CW, Troutman AG, Ney PA. Erythroid Maturation and Globin Gene Expression in Mice With Combined Deficiency of NF-E2 and Nrf-2 Blood. 91: 3459-3466. DOI: 10.1182/Blood.V91.9.3459  0.329
1997 Deveaux S, Cohen-Kaminsky S, Shivdasani RA, Andrews NC, Filipe A, Kuzniak I, Orkin SH, Roméo PH, Mignotte V. p45 NF-E2 regulates expression of thromboxane synthase in megakaryocytes. The Embo Journal. 16: 5654-61. PMID 9312024 DOI: 10.1093/Emboj/16.18.5654  0.365
1997 Shivdasani RA, Fujiwara Y, McDevitt MA, Orkin SH. A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development. The Embo Journal. 16: 3965-73. PMID 9233806 DOI: 10.1093/Emboj/16.13.3965  0.461
1997 McDevitt MA, Fujiwara Y, Shivdasani RA, Orkin SH. An upstream, DNase I hypersensitive region of the hematopoietic-expressed transcription factor GATA-1 gene confers developmental specificity in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 94: 7976-81. PMID 9223298 DOI: 10.1073/Pnas.94.15.7976  0.426
1997 McDevitt MA, Shivdasani RA, Fujiwara Y, Yang H, Orkin SH. A "knockdown" mutation created by cis-element gene targeting reveals the dependence of erythroid cell maturation on the level of transcription factor GATA-1. Proceedings of the National Academy of Sciences of the United States of America. 94: 6781-5. PMID 9192642 DOI: 10.1073/Pnas.94.13.6781  0.424
1997 Shivdasani RA, Fielder P, Keller G, Orkin SH, de Sauvage FJ. Regulation of the Serum Concentration of Thrombopoietin in Thrombocytopenic NF-E2 Knockout Mice Blood. 90: 1821-1827. DOI: 10.1182/Blood.V90.5.1821  0.336
1997 Chan F, Robinson J, Brownlie A, Shivdasani RA, Donovan A, Brugnara C, Kim J, Lau B, Witkowska HE, Zon LI. Characterization of Adult α- and β-Globin Genes in the Zebrafish Blood. 89: 688-700. DOI: 10.1182/Blood.V89.2.688  0.325
1995 Shivdasani RA, Rosenblatt MF, Zucker-Franklin D, Jackson CW, Hunt P, Saris CJ, Orkin SH. Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development. Cell. 81: 695-704. PMID 7774011 DOI: 10.1016/0092-8674(95)90531-6  0.361
1995 Shivdasani RA, Orkin SH. Erythropoiesis and globin gene expression in mice lacking the transcription factor NF-E2 Proceedings of the National Academy of Sciences of the United States of America. 92: 8690-8694. PMID 7567998 DOI: 10.1073/Pnas.92.19.8690  0.397
1990 Shivdasani RA, Esch TR, Chen GH, Thomas DW. Monoclonal antibodies define the characteristics and cellular distribution of an Ia-associated protein Hybridoma. 9: 17-30. PMID 2312130 DOI: 10.1089/Hyb.1990.9.17  0.318
1990 Bielinska A, Shivdasani RA, Zhang LQ, Nabel GJ. Regulation of gene expression with double-stranded phosphorothioate oligonucleotides. Science (New York, N.Y.). 250: 997-1000. PMID 2237444 DOI: 10.1126/Science.2237444  0.375
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