| Year |
Citation |
Score |
| 2020 |
Sambasivam V, Rao DN, Chandrasegaran S. Rewriting the Genome of the Model Eukaryote Saccharomyces cerevisiae Resonance. 25: 801-816. DOI: 10.1007/S12045-020-0997-8 |
0.407 |
|
| 2017 |
Chandrasegaran S. Recent advances in the use of ZFN-mediated gene editing for human gene therapy. Cell & Gene Therapy Insights. 3: 33-41. PMID 29270315 DOI: 10.18609/cgti.2017.005 |
0.402 |
|
| 2017 |
Chandrasegaran S, Bullen CK, Carroll D. Genome editing of human embryos: to edit or not to edit, that is the question. The Journal of Clinical Investigation. PMID 28846073 DOI: 10.1172/Jci96962 |
0.377 |
|
| 2017 |
Richardson SM, Mitchell LA, Stracquadanio G, Yang K, Dymond JS, DiCarlo JE, Lee D, Huang CL, Chandrasegaran S, Cai Y, Boeke JD, Bader JS. Design of a synthetic yeast genome. Science (New York, N.Y.). 355: 1040-1044. PMID 28280199 DOI: 10.1126/Science.Aaf4557 |
0.417 |
|
| 2016 |
Lu TK, Chandrasegaran S, Hodak H. The era of synthetic biology and genome engineering: Where no man has gone before. Journal of Molecular Biology. PMID 26827726 DOI: 10.1016/J.Jmb.2016.01.025 |
0.369 |
|
| 2015 |
Chandrasegaran S, Carroll D. Origins of Programmable Nucleases for Genome Engineering. Journal of Molecular Biology. PMID 26506267 DOI: 10.1016/J.Jmb.2015.10.014 |
0.554 |
|
| 2015 |
Annaluru N, Ramalingam S, Chandrasegaran S. Erratum to: Rewriting the blueprint of life by synthetic genomics and genome engineering. Genome Biology. 16: 159. PMID 26251160 DOI: 10.1186/S13059-015-0703-4 |
0.365 |
|
| 2015 |
Annaluru N, Ramalingam S, Chandrasegaran S. Rewriting the blueprint of life by synthetic genomics and genome engineering. Genome Biology. 16: 125. PMID 26076868 DOI: 10.1186/S13059-015-0689-Y |
0.43 |
|
| 2014 |
Ramalingam S, Annaluru N, Kandavelou K, Chandrasegaran S. TALEN-mediated generation and genetic correction of disease-specific human induced pluripotent stem cells. Current Gene Therapy. 14: 461-72. PMID 25245091 DOI: 10.2174/1566523214666140918101725 |
0.351 |
|
| 2014 |
Annaluru N, Muller H, Mitchell LA, Ramalingam S, Stracquadanio G, Richardson SM, Dymond JS, Kuang Z, Scheifele LZ, Cooper EM, Cai Y, Zeller K, Agmon N, Han JS, Hadjithomas M, ... ... Chandrasegaran S, et al. Total synthesis of a functional designer eukaryotic chromosome. Science (New York, N.Y.). 344: 55-8. PMID 24674868 DOI: 10.1126/Science.1249252 |
0.446 |
|
| 2013 |
Ramalingam S, Annaluru N, Chandrasegaran S. A CRISPR way to engineer the human genome. Genome Biology. 14: 107. PMID 23448668 DOI: 10.1186/Gb-2013-14-2-107 |
0.409 |
|
| 2013 |
Ramalingam S, London V, Kandavelou K, Cebotaru L, Guggino W, Civin C, Chandrasegaran S. Generation and genetic engineering of human induced pluripotent stem cells using designed zinc finger nucleases. Stem Cells and Development. 22: 595-610. PMID 22931452 DOI: 10.1089/Scd.2012.0245 |
0.438 |
|
| 2012 |
Muller H, Annaluru N, Schwerzmann JW, Richardson SM, Dymond JS, Cooper EM, Bader JS, Boeke JD, Chandrasegaran S. Assembling large DNA segments in yeast. Methods in Molecular Biology (Clifton, N.J.). 852: 133-50. PMID 22328431 DOI: 10.1007/978-1-61779-564-0_11 |
0.425 |
|
| 2012 |
Annaluru N, Muller H, Ramalingam S, Kandavelou K, London V, Richardson SM, Dymond JS, Cooper EM, Bader JS, Boeke JD, Chandrasegaran S. Assembling DNA fragments by USER fusion. Methods in Molecular Biology (Clifton, N.J.). 852: 77-95. PMID 22328427 DOI: 10.1007/978-1-61779-564-0_7 |
0.42 |
|
| 2011 |
Dymond JS, Richardson SM, Coombes CE, Babatz T, Muller H, Annaluru N, Blake WJ, Schwerzmann JW, Dai J, Lindstrom DL, Boeke AC, Gottschling DE, Chandrasegaran S, Bader JS, Boeke JD. Synthetic chromosome arms function in yeast and generate phenotypic diversity by design. Nature. 477: 471-6. PMID 21918511 DOI: 10.1038/Nature10403 |
0.472 |
|
| 2011 |
Ramalingam S, Kandavelou K, Rajenderan R, Chandrasegaran S. Creating designed zinc-finger nucleases with minimal cytotoxicity. Journal of Molecular Biology. 405: 630-41. PMID 21094162 DOI: 10.1016/J.Jmb.2010.10.043 |
0.532 |
|
| 2010 |
Meister GE, Chandrasegaran S, Ostermeier M. Heterodimeric DNA methyltransferases as a platform for creating designer zinc finger methyltransferases for targeted DNA methylation in cells. Nucleic Acids Research. 38: 1749-59. PMID 20007601 DOI: 10.1093/Nar/Gkp1126 |
0.459 |
|
| 2009 |
Kandavelou K, Ramalingam S, London V, Mani M, Wu J, Alexeev V, Civin CI, Chandrasegaran S. Targeted manipulation of mammalian genomes using designed zinc finger nucleases. Biochemical and Biophysical Research Communications. 388: 56-61. PMID 19635463 DOI: 10.1016/J.Bbrc.2009.07.112 |
0.734 |
|
| 2009 |
Kandavelou K, Chandrasegaran S. Custom-designed molecular scissors for site-specific manipulation of the plant and mammalian genomes. Methods in Molecular Biology (Clifton, N.J.). 544: 617-36. PMID 19488728 DOI: 10.1007/978-1-59745-483-4_40 |
0.589 |
|
| 2009 |
Dymond JS, Scheifele LZ, Richardson S, Lee P, Chandrasegaran S, Bader JS, Boeke JD. Teaching synthetic biology, bioinformatics and engineering to undergraduates: the interdisciplinary Build-a-Genome course. Genetics. 181: 13-21. PMID 19015540 DOI: 10.1534/Genetics.108.096784 |
0.408 |
|
| 2008 |
Meister GE, Chandrasegaran S, Ostermeier M. An engineered split M.HhaI-zinc finger fusion lacks the intended methyltransferase specificity. Biochemical and Biophysical Research Communications. 377: 226-30. PMID 18835252 DOI: 10.1016/J.Bbrc.2008.09.099 |
0.489 |
|
| 2008 |
Wu J, Kandavelou K, Chandrasegaran S. Custom-designed zinc finger nucleases: what is next? Cellular and Molecular Life Sciences : Cmls. 64: 2933-44. PMID 17763826 DOI: 10.1007/s00018-007-7206-8 |
0.526 |
|
| 2006 |
Durai S, Bosley A, Abulencia AB, Chandrasegaran S, Ostermeier M. A bacterial one-hybrid selection system for interrogating zinc finger-DNA interactions. Combinatorial Chemistry & High Throughput Screening. 9: 301-11. PMID 16724921 DOI: 10.2174/138620706776843147 |
0.444 |
|
| 2005 |
Durai S, Mani M, Kandavelou K, Wu J, Porteus MH, Chandrasegaran S. Zinc finger nucleases: custom-designed molecular scissors for genome engineering of plant and mammalian cells. Nucleic Acids Research. 33: 5978-90. PMID 16251401 DOI: 10.1093/Nar/Gki912 |
0.756 |
|
| 2005 |
Mani M, Kandavelou K, Dy FJ, Durai S, Chandrasegaran S. Design, engineering, and characterization of zinc finger nucleases. Biochemical and Biophysical Research Communications. 335: 447-57. PMID 16084494 DOI: 10.1016/J.Bbrc.2005.07.089 |
0.753 |
|
| 2005 |
Mani M, Smith J, Kandavelou K, Berg JM, Chandrasegaran S. Binding of two zinc finger nuclease monomers to two specific sites is required for effective double-strand DNA cleavage. Biochemical and Biophysical Research Communications. 334: 1191-7. PMID 16043120 DOI: 10.1016/J.Bbrc.2005.07.021 |
0.723 |
|
| 2005 |
Choe W, Chandrasegaran S, Ostermeier M. Protein fragment complementation in M.HhaI DNA methyltransferase. Biochemical and Biophysical Research Communications. 334: 1233-40. PMID 16040000 DOI: 10.1016/J.Bbrc.2005.07.017 |
0.38 |
|
| 2005 |
Kandavelou K, Mani M, Durai S, Chandrasegaran S. "Magic" scissors for genome surgery. Nature Biotechnology. 23: 686-7. PMID 15940239 DOI: 10.1038/Nbt0605-686 |
0.696 |
|
| 2001 |
Ruminy P, Derambure C, Chandrasegaran S, Salier JP. Long-range identification of hepatocyte nuclear factor-3 (FoxA) high and low-affinity binding sites with a chimeric nuclease. Journal of Molecular Biology. 310: 523-35. PMID 11439020 DOI: 10.1006/Jmbi.2001.4788 |
0.393 |
|
| 2001 |
Bibikova M, Carroll D, Segal DJ, Trautman JK, Smith J, Kim YG, Chandrasegaran S. Stimulation of homologous recombination through targeted cleavage by chimeric nucleases. Molecular and Cellular Biology. 21: 289-97. PMID 11113203 DOI: 10.1128/Mcb.21.1.289-297.2001 |
0.41 |
|
| 2000 |
Smith J, Bibikova M, Whitby FG, Reddy AR, Chandrasegaran S, Carroll D. Requirements for double-strand cleavage by chimeric restriction enzymes with zinc finger DNA-recognition domains. Nucleic Acids Research. 28: 3361-9. PMID 10954606 DOI: 10.1093/Nar/28.17.3361 |
0.488 |
|
| 2000 |
Zavala AG, Lancaster T, Groopman JD, Strickland PT, Chandrasegaran S. Phage display of ScFv peptides recognizing the thymidine(6-4)thymidine photoproduct Nucleic Acids Research. 28. PMID 10710441 DOI: 10.1093/Nar/28.7.E24 |
0.382 |
|
| 1999 |
Chandrasegaran S, Smith J. Chimeric restriction enzymes: what is next? Biological Chemistry. 380: 841-8. PMID 10494832 DOI: 10.1515/Bc.1999.103 |
0.537 |
|
| 1999 |
Smith J, Berg JM, Chandrasegaran S. A detailed study of the substrate specificity of a chimeric restriction enzyme. Nucleic Acids Research. 27: 674-81. PMID 9862996 DOI: 10.1093/Nar/27.2.674 |
0.445 |
|
| 1998 |
Kim YG, Smith J, Durgesha M, Chandrasegaran S. Chimeric restriction enzyme: Gal4 fusion to FokI cleavage domain. Biological Chemistry. 379: 489-95. PMID 9628342 DOI: 10.1515/Bchm.1998.379.4-5.489 |
0.452 |
|
| 1997 |
Kim YG, Shi Y, Berg JM, Chandrasegaran S. Site-specific cleavage of DNA-RNA hybrids by zinc finger/FokI cleavage domain fusions. Gene. 203: 43-9. PMID 9426005 DOI: 10.1016/S0378-1119(97)00489-7 |
0.452 |
|
| 1996 |
Kim YG, Cha J, Chandrasegaran S. Hybrid restriction enzymes: zinc finger fusions to Fok I cleavage domain. Proceedings of the National Academy of Sciences of the United States of America. 93: 1156-60. PMID 8577732 DOI: 10.1073/Pnas.93.3.1156 |
0.439 |
|
| 1994 |
Cha J, Bishai W, Chandrasegaran S. New vectors for direct cloning of PCR products. Gene. 136: 369-70. PMID 8294034 DOI: 10.1016/0378-1119(93)90498-R |
0.359 |
|
| 1994 |
Kim YG, Chandrasegaran S. Chimeric restriction endonuclease. Proceedings of the National Academy of Sciences of the United States of America. 91: 883-7. PMID 7905633 DOI: 10.1073/Pnas.91.3.883 |
0.485 |
|
| 1993 |
Li L, Chandrasegaran S. Alteration of the cleavage distance of Fok I restriction endonuclease by insertion mutagenesis. Proceedings of the National Academy of Sciences of the United States of America. 90: 2764-8. PMID 8464886 DOI: 10.1073/Pnas.90.7.2764 |
0.44 |
|
| 1993 |
Li L, Wu LP, Clarke R, Chandrasegaran S. C-terminal deletion mutants of the FokI restriction endonuclease. Gene. 133: 79-84. PMID 8224897 DOI: 10.1016/0378-1119(93)90227-T |
0.428 |
|
| 1992 |
Li L, Wu LP, Chandrasegaran S. Functional domains in Fok I restriction endonuclease. Proceedings of the National Academy of Sciences of the United States of America. 89: 4275-9. PMID 1584761 DOI: 10.1073/Pnas.89.10.4275 |
0.441 |
|
| 1992 |
Bassing CH, Kim YG, Li L, Chandrasegaran S. Overproduction, purification and characterization of M·HinfI methyltransferase and its deletion mutant Gene. 113: 83-88. PMID 1563635 DOI: 10.1016/0378-1119(92)90672-C |
0.446 |
|
| 1992 |
Kan TN, Li L, Chandrasegaran S. Cloning, sequencing, overproduction, and purification of M. CviBI (GANTC) methyltransferase from Chlorella virus NC-1A [corrected]. Gene. 121: 1-7. PMID 1427082 DOI: 10.1016/0378-1119(92)90155-I |
0.331 |
|
| 1990 |
Skoglund CM, Smith HO, Chandrasegaran S. Construction of an efficient overproducer clone of HinfI restriction endonuclease using the polymerase chain reaction Gene. 88: 1-5. PMID 2187744 DOI: 10.1016/0378-1119(90)90052-S |
0.388 |
|
| 1990 |
Smith HO, Annau TM, Chandrasegaran S. Finding sequence motifs in groups of functionally related proteins Proceedings of the National Academy of Sciences of the United States of America. 87: 826-830. PMID 1689055 DOI: 10.1073/Pnas.87.2.826 |
0.314 |
|
| 1988 |
Chandrasegaran S, Wu LP, Valda E, Smith HO. Overproduction and purification of the M·HhaII methyltransferase from Haemophilus haemolyticus Gene. 74: 15-21. PMID 3248721 DOI: 10.1016/0378-1119(88)90240-5 |
0.316 |
|
| 1988 |
Chandrasegaran S, Lunnen KD, Smith HO, Wilson GG. Cloning and sequencing the HinfI restriction and modification genes Gene. 70: 387-392. PMID 3063606 DOI: 10.1016/0378-1119(88)90210-7 |
0.385 |
|
| 1982 |
Miller PS, Chandrasegaran S, Dow DL, Pulford SM, Kan LS. Synthesis and template properties of an ethyl phosphotriester modified decadeoxyribonucleotide. Biochemistry. 21: 5468-74. PMID 7171569 DOI: 10.1021/Bi00265A014 |
0.352 |
|
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