| Year |
Citation |
Score |
| 2023 |
Taleb A, Willeit P, Amir S, Perkmann T, Kozma MO, Watzenböck ML, Binder CJ, Witztum JL, Tsimikas S. High Immunoglobulin-M Levels to Oxidation-Specific Epitopes Are Associated with Lower Risk of Acute Myocardial Infarction. Journal of Lipid Research. 100391. PMID 37211249 DOI: 10.1016/j.jlr.2023.100391 |
0.511 |
|
| 2022 |
Srikakulapu P, Pattarabanjird T, Upadhye A, Bontha SV, Osinski V, Marshall MA, Garmey J, Deroissart J, Prohaska TA, Witztum JL, Binder CJ, Holodick NE, Rothstein TL, McNamara CA. B-1b Cells Have Unique Functional Traits Compared to B-1a Cells at Homeostasis and in Aged Hyperlipidemic Mice With Atherosclerosis. Frontiers in Immunology. 13: 909475. PMID 35935999 DOI: 10.3389/fimmu.2022.909475 |
0.436 |
|
| 2020 |
Gonen A, Yang X, Yeang C, Alekseeva E, Koschinsky M, Witztum JL, Boffa MB, Tsimikas S. Generation and characterization of LPA-KIV9, a murine monoclonal antibody binding a single site on apolipoprotein(a). Journal of Lipid Research. PMID 32641432 DOI: 10.1194/Jlr.Ra120000830 |
0.343 |
|
| 2020 |
Biswas TK, VanderLaan PA, Que X, Gonen A, Krishack P, Binder CJ, Witztum JL, Getz GS, Reardon CA. CD1d Selectively Down Regulates the Expression of the Oxidized Phospholipid-Specific E06 IgM Natural Antibody in Mice. Antibodies (Basel, Switzerland). 9. PMID 32635160 DOI: 10.3390/Antib9030030 |
0.6 |
|
| 2020 |
Seidman JS, Troutman TD, Sakai M, Gola A, Spann NJ, Bennett H, Bruni CM, Ouyang Z, Li RZ, Sun X, Vu BT, Pasillas MP, Ego KM, Gosselin D, Link VM, ... ... Witztum JL, et al. Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis. Immunity. PMID 32362324 DOI: 10.1016/J.Immuni.2020.04.001 |
0.32 |
|
| 2020 |
Schnitzler J, Hoogeveen RM, Ali L, Prange KH, Waissi F, Van Weeghel MV, Bachmann JC, Versloot M, Borrelli MJ, Yeang C, de Kleijn D, Houtkooper RH, Koschinsky M, de Winther MP, Groen AK, ... Witztum JL, et al. Atherogenic Lipoprotein(A) Increases Vascular Glycolysis, Thereby Facilitating Inflammation and Leukocyte Extravasation. Circulation Research. PMID 32160811 DOI: 10.1161/Circresaha.119.316206 |
0.347 |
|
| 2020 |
Palmieri M, Teenamol J, Gomez-acevedo H, Witztum JL, Manolagas SC, Ambrogini E. SUN-346 A Natural Antibody Against Oxidized Phospholipids Attenuates Age-Related Bone Loss and Prevents Age-Related Glucose Intolerance in Mice Journal of the Endocrine Society. 4. DOI: 10.1210/Jendso/Bvaa046.640 |
0.327 |
|
| 2019 |
Sun X, Seidman JS, Zhao P, Troutman TD, Spann NJ, Que X, Zhou F, Liao Z, Pasillas M, Yang X, Magida JA, Kisseleva T, Brenner DA, Downes M, Evans RM, ... ... Witztum JL, et al. Neutralization of Oxidized Phospholipids Ameliorates Non-alcoholic Steatohepatitis. Cell Metabolism. PMID 31761566 DOI: 10.1016/J.Cmet.2019.10.014 |
0.37 |
|
| 2019 |
Boffa MB, Marar TT, Yeang C, Viney NJ, Xia S, Witztum JL, Koschinsky ML, Tsimikas SL. Potent reduction of plasma lipoprotein(a) with an antisense oligonucleotide in human subjects does not affect ex vivo fibrinolysis. Journal of Lipid Research. PMID 31551368 DOI: 10.1194/Jlr.P094763 |
0.318 |
|
| 2019 |
Upadhye A, Srikakulapu P, Gonen A, Hendrikx S, Perry HM, Nguyen AT, McSkimming C, Marshall M, Garmey J, Taylor A, Bender TP, Tsimikas S, Holodick NE, Rothstein TL, Witztum JL, et al. Diversification and CXCR4-Dependent Establishment of the Bone Marrow B-1a Cell Pool Governs Atheroprotective IgM Production Linked To Human Coronary Atherosclerosis. Circulation Research. PMID 31549940 DOI: 10.1161/Circresaha.119.315786 |
0.332 |
|
| 2019 |
Tsimikas S, Gordts PLSM, Nora C, Yeang C, Witztum JL. Statin therapy increases lipoprotein(a) levels. European Heart Journal. PMID 31111151 DOI: 10.1093/Eurheartj/Ehz310 |
0.324 |
|
| 2019 |
Ramms B, Patel S, Nora C, Pessentheiner AR, Chang MW, Green CR, Golden GJ, Secrest P, Krauss RM, Metallo CM, Benner C, Alexander VJ, Witztum JL, Tsimikas S, Esko JD, et al. ApoC-III ASO Promotes Tissue LPL Activity in Absence of ApoE-Mediated TRL Clearance. Journal of Lipid Research. PMID 31092690 DOI: 10.1194/Jlr.M093740 |
0.358 |
|
| 2019 |
Zheng KH, Tsimikas S, Pawade T, Kroon J, Jenkins WSA, Doris MK, White AC, Timmers NKLM, Hjortnaes J, Rogers MA, Aikawa E, Arsenault BJ, Witztum JL, Newby DE, Koschinsky ML, et al. Lipoprotein(a) and Oxidized Phospholipids Promote Valve Calcification in Patients With Aortic Stenosis. Journal of the American College of Cardiology. 73: 2150-2162. PMID 31047003 DOI: 10.1016/J.Jacc.2019.01.070 |
0.381 |
|
| 2019 |
Posod A, Pechlaner R, Yin X, Burnap SA, Kiechl SJ, Willeit J, Witztum JL, Mayr M, Kiechl S, Kiechl-Kohlendorfer U. Apolipoprotein Profiles in Very Preterm and Term-Born Preschool Children. Journal of the American Heart Association. 8: e011199. PMID 30968745 DOI: 10.1161/Jaha.118.011199 |
0.305 |
|
| 2018 |
Gonen A, Choi SH, Miu P, Agatisa-Boyle C, Acks D, Taylor AM, McNamara CA, Tsimikas S, Witztum JL, Miller YI. A monoclonal antibody to assess oxidized cholesteryl esters associated with apoAI and apoB-100 lipoproteins in human plasma. Journal of Lipid Research. PMID 30563909 DOI: 10.1194/Jlr.D090852 |
0.449 |
|
| 2018 |
Riopel M, Vassallo M, Ehinger E, Pattison J, Bowden K, Winkels H, Wilson M, de Jong R, Patel S, Balakrishna D, Bilakovics J, Fanjul A, Plonowski A, Larson CJ, Ley K, ... ... Witztum JL, et al. CX3CL1-Fc treatment prevents atherosclerosis in Ldlr KO mice. Molecular Metabolism. PMID 30553772 DOI: 10.1016/J.Molmet.2018.11.011 |
0.331 |
|
| 2018 |
van Capelleveen JC, Lee SR, Verbeek R, Kastelein JJP, Wareham NJ, Stroes ESG, Hovingh GK, Khaw KT, Boekholdt SM, Witztum JL, Tsimikas S. Relationship of lipoprotein-associated apolipoprotein C-III with lipid variables and coronary artery disease risk: The EPIC-Norfolk prospective population study. Journal of Clinical Lipidology. PMID 30249512 DOI: 10.1016/J.Jacl.2018.08.010 |
0.313 |
|
| 2018 |
Tsimikas S, Fazio S, Viney NJ, Xia S, Witztum JL, Marcovina SM. Relationship of lipoprotein(a) molar concentrations and mass according to lipoprotein(a) thresholds and apolipoprotein(a) isoform size. Journal of Clinical Lipidology. PMID 30100157 DOI: 10.1016/J.Jacl.2018.07.003 |
0.312 |
|
| 2018 |
Que X, Hung MY, Yeang C, Gonen A, Prohaska TA, Sun X, Diehl C, Määttä A, Gaddis DE, Bowden K, Pattison J, MacDonald JG, Ylä-Herttuala S, Mellon PL, Hedrick CC, ... ... Witztum JL, et al. Publisher Correction: Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice. Nature. PMID 30013121 DOI: 10.1038/S41586-018-0313-X |
0.509 |
|
| 2018 |
Que X, Hung MY, Yeang C, Gonen A, Prohaska TA, Sun X, Diehl C, Määttä A, Gaddis DE, Bowden K, Pattison J, MacDonald JG, Ylä-Herttuala S, Mellon PL, Hedrick CC, ... ... Witztum JL, et al. Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice. Nature. PMID 29875409 DOI: 10.1038/S41586-018-0198-8 |
0.6 |
|
| 2018 |
Ambrogini E, Que X, Wang S, Yamaguchi F, Weinstein RS, Tsimikas S, Manolagas SC, Witztum JL, Jilka RL. Oxidation-specific epitopes restrain bone formation. Nature Communications. 9: 2193. PMID 29875355 DOI: 10.1038/S41467-018-04047-5 |
0.319 |
|
| 2018 |
Yeang C, Hasanally D, Que X, Hung MY, Stemankovic A, Chan D, Chaudhary R, Margulets V, Edel AL, Hoshijima M, Gu Y, Bradford W, Dalton N, Miu P, Cheung DYC, ... ... Witztum JL, et al. Reduction of Myocardial Ischemia-Reperfusion Injury by Inactivating Oxidized Phospholipids. Cardiovascular Research. PMID 29850765 DOI: 10.1093/Cvr/Cvy136 |
0.34 |
|
| 2018 |
Viney NJ, Yeang C, Yang X, Xia S, Witztum JL, Tsimikas S. Relationship between "LDL-C", estimated true LDL-C, apolipoprotein B-100, and PCSK9 levels following lipoprotein(a) lowering with an antisense oligonucleotide. Journal of Clinical Lipidology. PMID 29574075 DOI: 10.1016/J.Jacl.2018.02.014 |
0.342 |
|
| 2018 |
Senders ML, Que X, Cho YS, Yeang C, Groenen H, Fay F, Calcagno C, Meerwaldt AE, Green S, Miu P, Lobatto ME, Reiner T, Fayad ZA, Witztum JL, Mulder WJM, et al. PET/MR Imaging of Malondialdehyde-Acetaldehyde Epitopes With a Human Antibody Detects Clinically Relevant Atherothrombosis. Journal of the American College of Cardiology. 71: 321-335. PMID 29348025 DOI: 10.1016/J.Jacc.2017.11.036 |
0.338 |
|
| 2018 |
Tsimikas S, Fazio S, Ferdinand KC, Ginsberg HN, Koschinsky ML, Marcovina SM, Moriarty PM, Rader DJ, Remaley AT, Reyes-Soffer G, Santos RD, Thanassoulis G, Witztum JL, Danthi S, Olive M, et al. NHLBI Working Group Recommendations to Reduce Lipoprotein(a)-Mediated Risk of Cardiovascular Disease and Aortic Stenosis. Journal of the American College of Cardiology. 71: 177-192. PMID 29325642 DOI: 10.1016/J.Jacc.2017.11.014 |
0.306 |
|
| 2018 |
Alexander VJ, Digenio A, Xia S, Hurh E, Hughes S, Geary RS, Witztum JL, Tsimikas S. INHIBITION OF APOLIPOPROTEIN C-III WITH GALNAC CONJUGATED ANTISENSE DRUG POTENTLY LOWERS FASTING SERUM APOLIPOPROTEIN C-III AND TRIGLYCERIDE LEVELS IN HEALTHY VOLUNTEERS WITH ELEVATED TRIGLYCERIDES Journal of the American College of Cardiology. 71: A1724. DOI: 10.1016/S0735-1097(18)32265-4 |
0.344 |
|
| 2017 |
Naka KK, Bechlioullis A, Marini A, Sionis D, Vakalis K, Triantis G, Wilkins L, Rogus J, Kornman KS, Witztum JL, Doucette-Stamm L, Michalis LK, Tsimikas S. Interleukin-1 genotypes modulate the long-term effect of lipoprotein(a) on cardiovascular events: The Ioannina Study. Journal of Clinical Lipidology. PMID 29310992 DOI: 10.1016/J.Jacl.2017.12.004 |
0.306 |
|
| 2017 |
Marcovina SM, Viney NJ, Hughes SG, Xia S, Witztum JL, Tsimikas S. Temporal variability in lipoprotein(a) levels in patients enrolled in the placebo arms of IONIS-APO(a)Rx and IONIS-APO(a)-LRx antisense oligonucleotide clinical trials. Journal of Clinical Lipidology. PMID 29174389 DOI: 10.1016/J.Jacl.2017.10.024 |
0.315 |
|
| 2017 |
Kamstrup PR, Hung MY, Witztum JL, Tsimikas S, Nordestgaard BG. Oxidized Phospholipids and Risk of Calcific Aortic Valve Disease: The Copenhagen General Population Study. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 28572160 DOI: 10.1161/Atvbaha.116.308761 |
0.363 |
|
| 2017 |
Graham MJ, Lee RG, Brandt TA, Tai LJ, Fu W, Peralta R, Yu R, Hurh E, Paz E, McEvoy BW, Baker BF, Pham NC, Digenio A, Hughes SG, Geary RS, ... Witztum JL, et al. Cardiovascular and Metabolic Effects of ANGPTL3 Antisense Oligonucleotides. The New England Journal of Medicine. PMID 28538111 DOI: 10.1056/Nejmoa1701329 |
0.376 |
|
| 2017 |
Prasad A, Clopton P, Ayers C, Khera A, de Lemos JA, Witztum JL, Tsimikas S. Relationship of Autoantibodies to MDA-LDL and ApoB-Immune Complexes to Sex, Ethnicity, Subclinical Atherosclerosis, and Cardiovascular Events. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 28473443 DOI: 10.1161/Atvbaha.117.309101 |
0.406 |
|
| 2017 |
van Capelleveen JC, Bernelot Moens SJ, Yang X, Kastelein JJP, Wareham NJ, Zwinderman AH, Stroes ESG, Witztum JL, Hovingh GK, Khaw KT, Boekholdt SM, Tsimikas S. Apolipoprotein CIII Levels and Incident Coronary Artery Disease Risk: The EPIC-Norfolk Prospective Population Study. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 28473441 DOI: 10.1161/Atvbaha.117.309007 |
0.334 |
|
| 2017 |
Capoulade R, Chan KL, Mathieu P, Bossé Y, Dumesnil JG, Tam JW, Teo KK, Yang X, Witztum JL, Arsenault BJ, Després JP, Pibarot P, Tsimikas S. Autoantibodies and immune complexes to oxidation-specific epitopes and progression of aortic stenosis: Results from the ASTRONOMER trial. Atherosclerosis. 260: 1-7. PMID 28319871 DOI: 10.1016/J.Atherosclerosis.2017.03.013 |
0.421 |
|
| 2017 |
Pechlaner R, Tsimikas S, Yin X, Willeit P, Baig F, Santer P, Oberhollenzer F, Egger G, Witztum JL, Alexander VJ, Willeit J, Kiechl S, Mayr M. Very-Low-Density Lipoprotein-Associated Apolipoproteins Predict Cardiovascular Events and Are Lowered by Inhibition of APOC-III. Journal of the American College of Cardiology. 69: 789-800. PMID 28209220 DOI: 10.1016/J.Jacc.2016.11.065 |
0.353 |
|
| 2017 |
Naka K, Bechlioulis A, Douchette-Stamm L, Wilkins L, Marini A, Bougiakli M, Giannitsi S, Rogus J, Kornman K, Witztum J, Tsimikas S, Michalis L. P1761Diabetic status influences the effect of pro-inflammatory interleukin-1 genotypes on lipoprotein(a) mediated risk of coronary artery disease and cardiovascular events European Heart Journal. 38. DOI: 10.1093/Eurheartj/Ehx502.P1761 |
0.317 |
|
| 2017 |
Tsimikas S, Prasad A, Clopton P, Ayers C, Khera A, de Lemos J, Witztum J. RELATIONSHIP OF BIOMARKERS OF OXIDIZED LIPOPROTEINS TO ETHNICITY, SUBCLINICAL ATHEROSCLEROSIS AND CARDIOVASCULAR EVENTS OVER A 10.5 YEAR FOLLOW-UP IN THE DALLAS HEART STUDY Journal of the American College of Cardiology. 69: 64. DOI: 10.1016/S0735-1097(17)33453-8 |
0.414 |
|
| 2017 |
Yin X, Pechlaner R, Tsimikas S, Baig F, Haudebourg E, Witztum JL, Willeit J, Kiechl S, Mayr M. Very low-density lipoprotein associated apolipoproteins predict cardiovascular events and are lowered by inhibition of apoC-III Atherosclerosis Supplements. 28. DOI: 10.1016/J.Atherosclerosissup.2017.08.002 |
0.343 |
|
| 2016 |
Ito A, Hong C, Oka K, Salazar JV, Diehl C, Witztum JL, Diaz M, Castrillo A, Bensinger SJ, Chan L, Tontonoz P. Cholesterol Accumulation in CD11c(+) Immune Cells Is a Causal and Targetable Factor in Autoimmune Disease. Immunity. 45: 1311-1326. PMID 28002731 DOI: 10.1016/J.Immuni.2016.11.008 |
0.424 |
|
| 2016 |
Viney NJ, van Capelleveen JC, Geary RS, Xia S, Tami JA, Yu RZ, Marcovina SM, Hughes SG, Graham MJ, Crooke RM, Crooke ST, Witztum JL, Stroes ES, Tsimikas S. Antisense oligonucleotides targeting apolipoprotein(a) in people with raised lipoprotein(a): two randomised, double-blind, placebo-controlled, dose-ranging trials. Lancet (London, England). PMID 27665230 DOI: 10.1016/S0140-6736(16)31009-1 |
0.31 |
|
| 2016 |
Duell PB, Santos RD, Kirwan BA, Witztum JL, Tsimikas S, Kastelein JJ. Long-term mipomersen treatment is associated with a reduction in cardiovascular events in patients with familial hypercholesterolemia. Journal of Clinical Lipidology. 10: 1011-21. PMID 27578134 DOI: 10.1016/J.Jacl.2016.04.013 |
0.32 |
|
| 2016 |
van der Valk FM, Bekkering S, Kroon J, Yeang C, Van den Bossche J, van Buul JD, Ravandi A, Nederveen AJ, Verberne HJ, Scipione C, Nieuwdorp M, Joosten LA, Netea MG, Koschinsky ML, Witztum JL, et al. Oxidized Phospholipids on Lipoprotein(a) Elicit Arterial Wall Inflammation and an Inflammatory Monocyte Response in Humans. Circulation. PMID 27496857 DOI: 10.1161/Circulationaha.116.020838 |
0.406 |
|
| 2016 |
Gordts PL, Nock R, Son NH, Ramms B, Lew I, Gonzales JC, Thacker BE, Basu D, Lee RG, Mullick AE, Graham MJ, Goldberg IJ, Crooke RM, Witztum JL, Esko JD. ApoC-III inhibits clearance of triglyceride-rich lipoproteins through LDL family receptors. The Journal of Clinical Investigation. PMID 27400128 DOI: 10.1172/Jci86610 |
0.382 |
|
| 2016 |
Binder CJ, Papac-Milicevic N, Witztum JL. Innate sensing of oxidation-specific epitopes in health and disease. Nature Reviews. Immunology. PMID 27346802 DOI: 10.1038/Nri.2016.63 |
0.594 |
|
| 2016 |
Nsaibia MJ, Mahmut A, Boulanger MC, Arsenault BJ, Bouchareb R, Simard S, Witztum JL, Clavel MA, Pibarot P, Bossé Y, Tsimikas S, Mathieu P. Autotaxin interacts with lipoprotein(a) and oxidized phospholipids in predicting the risk of calcific aortic valve stenosis in patients with coronary artery disease. Journal of Internal Medicine. PMID 27237700 DOI: 10.1111/Joim.12519 |
0.374 |
|
| 2016 |
Yeang C, Hung MY, Byun YS, Clopton P, Yang X, Witztum JL, Tsimikas S. Effect of therapeutic interventions on oxidized phospholipids on apolipoprotein B100 and lipoprotein(a). Journal of Clinical Lipidology. 10: 594-603. PMID 27206947 DOI: 10.1016/J.Jacl.2016.01.005 |
0.421 |
|
| 2016 |
Gruber S, Hendrikx T, Tsiantoulas D, Ozsvar-Kozma M, Göderle L, Mallat Z, Witztum JL, Shiri-Sverdlov R, Nitschke L, Binder CJ. Sialic Acid-Binding Immunoglobulin-like Lectin G Promotes Atherosclerosis and Liver Inflammation by Suppressing the Protective Functions of B-1 Cells. Cell Reports. 14: 2348-61. PMID 26947073 DOI: 10.1016/J.Celrep.2016.02.027 |
0.568 |
|
| 2016 |
Yang X, Lee SR, Choi YS, Alexander VJ, Digenio A, Yang Q, Miller YI, Witztum JL, Tsimikas S. Reduction in lipoprotein-associated apoC-III levels following volanesorsen therapy: Phase 2 randomized trial results. Journal of Lipid Research. PMID 26848137 DOI: 10.1194/Jlr.M066399 |
0.349 |
|
| 2016 |
Verbeek R, Boekholdt SM, Stoekenbroek RM, Hovingh GK, Witztum JL, Wareham NJ, Sandhu MS, Khaw KT, Tsimikas S. Population and Assay Thresholds for the Predictive Value of Lipoprotein(a) for Coronary Artery Disease: The EPIC-Norfolk Prospective Population Study. Journal of Lipid Research. PMID 26828068 DOI: 10.1194/Jlr.P066258 |
0.308 |
|
| 2016 |
Foks AC, Engelbertsen D, Kuperwaser F, Alberts-Grill N, Gonen A, Witztum JL, Lederer J, Jarolim P, DeKruyff RH, Freeman GJ, Lichtman AH. Blockade of Tim-1 and Tim-4 Enhances Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 26821944 DOI: 10.1161/Atvbaha.115.306860 |
0.359 |
|
| 2016 |
Yeang C, Miu P, Green S, Yang X, Hung MY, Witztum J, Tsimikas S. DEFINING THE MECHANISM OF LP(A) LOWERING BY ALIROCUMAB IN TRANSGENIC MOUSE MODELS Journal of the American College of Cardiology. 67: 2259. DOI: 10.1016/S0735-1097(16)32260-4 |
0.332 |
|
| 2016 |
Gruber S, Hendrikx T, Tsiantoulas D, Ozsvar-Kozma M, Göderle L, Mallat Z, Witztum JL, Shiri-Sverdlov R, Nitschke L, Binder CJ. Sialic Acid-Binding Immunoglobulin-like Lectin G Promotes Atherosclerosis and Liver Inflammation by Suppressing the Protective Functions of B-1 Cells Cell Reports. 14: 2348-2361. DOI: 10.1016/j.celrep.2016.02.027 |
0.515 |
|
| 2016 |
Yeang C, Miu P, Green S, Yang X, Hung M, Witztum J, Tsimikas S. Defining the mechanism of lipoprotein(a) [Lp(a)] lowering by alirocumab in transgenic mouse models Atherosclerosis. 252: e124. DOI: 10.1016/J.Atherosclerosis.2016.07.650 |
0.314 |
|
| 2016 |
Yeang C, Hung M, Pattison J, Bowden K, Dalton N, Peterson K, Witztum J, Tsimikas S, Que X. Expression of E06, a natural monoclonal antibody targeted to oxidized phospholipids (OXPL), attenuates the progression of aortic sclerosis in aged hyperlipidemic mice Atherosclerosis. 252: e229. DOI: 10.1016/J.Atherosclerosis.2016.07.212 |
0.35 |
|
| 2015 |
Capoulade R, Chan KL, Yeang C, Mathieu P, Bossé Y, Dumesnil JG, Tam JW, Teo KK, Mahmut A, Yang X, Witztum JL, Arsenault BJ, Després JP, Pibarot P, Tsimikas S. Oxidized Phospholipids, Lipoprotein(a), and Progression of Calcific Aortic Valve Stenosis. Journal of the American College of Cardiology. 66: 1236-46. PMID 26361154 DOI: 10.1016/J.Jacc.2015.07.020 |
0.382 |
|
| 2015 |
Witztum JL. CEP Is an Important and Ubiquitous Oxidation Specific Epitope Recognized by Innate Pattern Recognition Receptors. Circulation Research. 117: 305-8. PMID 26227873 DOI: 10.1161/Circresaha.115.306928 |
0.432 |
|
| 2015 |
Gaudet D, Alexander VJ, Baker BF, Brisson D, Tremblay K, Singleton W, Geary RS, Hughes SG, Viney NJ, Graham MJ, Crooke RM, Witztum JL, Brunzell JD, Kastelein JJ. Antisense Inhibition of Apolipoprotein C-III in Patients with Hypertriglyceridemia. The New England Journal of Medicine. 373: 438-47. PMID 26222559 DOI: 10.1056/Nejmoa1400283 |
0.313 |
|
| 2015 |
Tsimikas S, Viney NJ, Hughes SG, Singleton W, Graham MJ, Baker BF, Burkey JL, Yang Q, Marcovina SM, Geary RS, Crooke RM, Witztum JL. Antisense therapy targeting apolipoprotein(a): a randomised, double-blind, placebo-controlled phase 1 study. Lancet (London, England). 386: 1472-83. PMID 26210642 DOI: 10.1016/S0140-6736(15)61252-1 |
0.32 |
|
| 2015 |
Glass CK, Witztum JL. Daniel Steinberg, 1922-2015. Proceedings of the National Academy of Sciences of the United States of America. 112: 9791-2. PMID 26209653 DOI: 10.1073/Pnas.1512413112 |
0.384 |
|
| 2015 |
Liu C, Gates KP, Fang L, Amar MJ, Schneider DA, Geng H, Huang W, Kim J, Pattison J, Zhang J, Witztum JL, Remaley AT, Dong PD, Miller YI. Apoc2 loss-of-function zebrafish mutant as a genetic model of hyperlipidemia. Disease Models & Mechanisms. 8: 989-98. PMID 26044956 DOI: 10.1242/Dmm.019836 |
0.328 |
|
| 2015 |
Rao F, Schork AJ, Maihofer AX, Nievergelt CM, Marcovina SM, Miller ER, Witztum JL, O'Connor DT, Tsimikas S. Heritability of Biomarkers of Oxidized Lipoproteins: Twin Pair Study. Arteriosclerosis, Thrombosis, and Vascular Biology. 35: 1704-11. PMID 25953646 DOI: 10.1161/Atvbaha.115.305306 |
0.385 |
|
| 2015 |
Choi SH, Gonen A, Diehl CJ, Kim J, Almazan F, Witztum JL, Miller YI. SYK regulates macrophage MHC-II expression via activation of autophagy in response to oxidized LDL. Autophagy. 11: 785-95. PMID 25946330 DOI: 10.1080/15548627.2015.1037061 |
0.393 |
|
| 2015 |
Yeang C, Witztum JL, Tsimikas S. 'LDL-C' = LDL-C + Lp(a)-C: implications of achieved ultra-low LDL-C levels in the proprotein convertase subtilisin/kexin type 9 era of potent LDL-C lowering. Current Opinion in Lipidology. 26: 169-78. PMID 25943842 DOI: 10.1097/Mol.0000000000000171 |
0.318 |
|
| 2015 |
Byun YS, Lee JH, Arsenault BJ, Yang X, Bao W, DeMicco D, Laskey R, Witztum JL, Tsimikas S. Relationship of oxidized phospholipids on apolipoprotein B-100 to cardiovascular outcomes in patients treated with intensive versus moderate atorvastatin therapy: the TNT trial. Journal of the American College of Cardiology. 65: 1286-95. PMID 25835440 DOI: 10.1016/J.Jacc.2015.01.050 |
0.363 |
|
| 2015 |
Santos RD, Raal FJ, Catapano AL, Witztum JL, Steinhagen-Thiessen E, Tsimikas S. Mipomersen, an antisense oligonucleotide to apolipoprotein B-100, reduces lipoprotein(a) in various populations with hypercholesterolemia: results of 4 phase III trials. Arteriosclerosis, Thrombosis, and Vascular Biology. 35: 689-99. PMID 25614280 DOI: 10.1161/Atvbaha.114.304549 |
0.342 |
|
| 2015 |
Fernandez JA, Deguchi H, Banka CL, Witztum JL, Griffin JH. Re-evaluation of the anticoagulant properties of high-density lipoprotein-brief report. Arteriosclerosis, Thrombosis, and Vascular Biology. 35: 570-2. PMID 25550205 DOI: 10.1161/Atvbaha.114.304938 |
0.363 |
|
| 2015 |
Tsiantoulas D, Perkmann T, Afonyushkin T, Mangold A, Prohaska TA, Papac-Milicevic N, Millischer V, Bartel C, Hörkkö S, Boulanger CM, Tsimikas S, Fischer MB, Witztum JL, Lang IM, Binder CJ. Circulating microparticles carry oxidation-specific epitopes and are recognized by natural IgM antibodies. Journal of Lipid Research. 56: 440-8. PMID 25525116 DOI: 10.1194/Jlr.P054569 |
0.587 |
|
| 2015 |
Yeang C, Clopton P, Yang X, Witztum J. NIACIN REDUCES OXIDIZED PHOSPHOLIPIDS ON APOLIPOPROTEIN-B-100 (OXPL/APOB) CONTAINING LIPOPROTEINS Journal of the American College of Cardiology. 65: A1376. DOI: 10.1016/S0735-1097(15)61376-6 |
0.443 |
|
| 2015 |
Byun YS, Yang X, Weihang B, DeMicco D, Laskey R, Witztum J, Tsimikas S. ELEVATED LEVELS OF OXIDIZED PHOSPHOLIPIDS ON APOLIPOPROTEIN B-100 PREDICT RECURRENT CEREBROVASCULAR EVENTS: A STROKE PREVENTION BY AGGRESSIVE REDUCTION IN CHOLESTEROL LEVELS (SPARCL) SUBSTUDY Journal of the American College of Cardiology. 65: A1374. DOI: 10.1016/S0735-1097(15)61374-2 |
0.344 |
|
| 2015 |
Brandt T, Lee R, Digenio A, Graham M, Crooke R, Hughes S, Singleton W, Witztum J, Tsimikas S. ISIS-ANGPTL3RX, an antisense inhibitor to angiopoietin-like 3, reduces plasma lipid levels in mouse models and in healthy human volunteers Atherosclerosis. 241: e30-e31. DOI: 10.1016/J.Atherosclerosis.2015.04.115 |
0.313 |
|
| 2014 |
Gaudet D, Brisson D, Tremblay K, Alexander VJ, Singleton W, Hughes SG, Geary RS, Baker BF, Graham MJ, Crooke RM, Witztum JL. Targeting APOC3 in the familial chylomicronemia syndrome. The New England Journal of Medicine. 371: 2200-6. PMID 25470695 DOI: 10.1056/Nejmoa1400284 |
0.318 |
|
| 2014 |
Gordts PL, Foley EM, Lawrence R, Sinha R, Lameda-Diaz C, Deng L, Nock R, Glass CK, Erbilgin A, Lusis AJ, Witztum JL, Esko JD. Reducing macrophage proteoglycan sulfation increases atherosclerosis and obesity through enhanced type I interferon signaling. Cell Metabolism. 20: 813-26. PMID 25440058 DOI: 10.1016/J.Cmet.2014.09.016 |
0.326 |
|
| 2014 |
Baldan A, Gonen A, Choung C, Que X, Marquart TJ, Hernandez I, Bjorkhem I, Ford DA, Witztum JL, Tarling EJ. ABCG1 is required for pulmonary B-1 B cell and natural antibody homeostasis. Journal of Immunology (Baltimore, Md. : 1950). 193: 5637-48. PMID 25339664 DOI: 10.4049/Jimmunol.1400606 |
0.453 |
|
| 2014 |
Briley-Saebo K, Yeang C, Witztum JL, Tsimikas S. Imaging of oxidation-specific epitopes with targeted nanoparticles to detect high-risk atherosclerotic lesions: progress and future directions. Journal of Cardiovascular Translational Research. 7: 719-36. PMID 25297940 DOI: 10.1007/S12265-014-9590-4 |
0.365 |
|
| 2014 |
Willeit P, Kiechl S, Kronenberg F, Witztum JL, Santer P, Mayr M, Xu Q, Mayr A, Willeit J, Tsimikas S. Discrimination and net reclassification of cardiovascular risk with lipoprotein(a): prospective 15-year outcomes in the Bruneck Study. Journal of the American College of Cardiology. 64: 851-60. PMID 25169167 DOI: 10.1016/J.Jacc.2014.03.061 |
0.302 |
|
| 2014 |
Gonen A, Hansen LF, Turner WW, Montano EN, Que X, Rafia A, Chou MY, Wiesner P, Tsiantoulas D, Corr M, VanNieuwenhze MS, Tsimikas S, Binder CJ, Witztum JL, Hartvigsen K. Atheroprotective immunization with malondialdehyde-modified LDL is hapten specific and dependent on advanced MDA adducts: implications for development of an atheroprotective vaccine. Journal of Lipid Research. 55: 2137-55. PMID 25143462 DOI: 10.1194/Jlr.M053256 |
0.576 |
|
| 2014 |
Tsiantoulas D, Diehl CJ, Witztum JL, Binder CJ. B cells and humoral immunity in atherosclerosis. Circulation Research. 114: 1743-56. PMID 24855199 DOI: 10.1161/Circresaha.113.301145 |
0.545 |
|
| 2014 |
Wang M, Subramanian M, Abramowicz S, Murphy AJ, Gonen A, Witztum J, Welch C, Tabas I, Westerterp M, Tall AR. Interleukin-3/granulocyte macrophage colony-stimulating factor receptor promotes stem cell expansion, monocytosis, and atheroma macrophage burden in mice with hematopoietic ApoE deficiency. Arteriosclerosis, Thrombosis, and Vascular Biology. 34: 976-84. PMID 24651678 DOI: 10.1161/Atvbaha.113.303097 |
0.348 |
|
| 2014 |
Ravandi A, Leibundgut G, Hung MY, Patel M, Hutchins PM, Murphy RC, Prasad A, Mahmud E, Miller YI, Dennis EA, Witztum JL, Tsimikas S. Release and capture of bioactive oxidized phospholipids and oxidized cholesteryl esters during percutaneous coronary and peripheral arterial interventions in humans. Journal of the American College of Cardiology. 63: 1961-71. PMID 24613321 DOI: 10.1016/J.Jacc.2014.01.055 |
0.34 |
|
| 2014 |
Tsimikas S, Duff GW, Berger PB, Rogus J, Huttner K, Clopton P, Brilakis E, Kornman KS, Witztum JL. Pro-inflammatory interleukin-1 genotypes potentiate the risk of coronary artery disease and cardiovascular events mediated by oxidized phospholipids and lipoprotein(a). Journal of the American College of Cardiology. 63: 1724-34. PMID 24530664 DOI: 10.1016/J.Jacc.2013.12.030 |
0.368 |
|
| 2014 |
Hilgendorf I, Theurl I, Gerhardt LM, Robbins CS, Weber GF, Gonen A, Iwamoto Y, Degousee N, Holderried TA, Winter C, Zirlik A, Lin HY, Sukhova GK, Butany J, Rubin BB, ... Witztum JL, et al. Innate response activator B cells aggravate atherosclerosis by stimulating T helper-1 adaptive immunity. Circulation. 129: 1677-87. PMID 24488984 DOI: 10.1161/Circulationaha.113.006381 |
0.392 |
|
| 2014 |
Hung MY, Witztum JL, Tsimikas S. New therapeutic targets for calcific aortic valve stenosis: the lipoprotein(a)-lipoprotein-associated phospholipase A2-oxidized phospholipid axis. Journal of the American College of Cardiology. 63: 478-80. PMID 24161316 DOI: 10.1016/J.Jacc.2013.08.1639 |
0.316 |
|
| 2014 |
Witztum JL, Lichtman AH. The influence of innate and adaptive immune responses on atherosclerosis. Annual Review of Pathology. 9: 73-102. PMID 23937439 DOI: 10.1146/Annurev-Pathol-020712-163936 |
0.367 |
|
| 2014 |
Dijk RAV, Kolodgie F, Ravandi A, Leibundgut G, Hu PP, Prasad A, Mahmud E, Dennis E, Curtiss LK, Witztum JL, Wasserman BA, Otsuka F, Virmani R, Tsimikas S. Erratum: Differential expression of oxidation-specifi c epitopes and apolipoprotein(a) in progressing and ruptured human coronary and carotid atherosclerotic lesions (J. Lipid Res. (2012) 53 (2773-2790) Journal of Lipid Research. 55. DOI: 10.1194/Jlr.P030890Err |
0.384 |
|
| 2013 |
Tse K, Gonen A, Sidney J, Ouyang H, Witztum JL, Sette A, Tse H, Ley K. Atheroprotective Vaccination with MHC-II Restricted Peptides from ApoB-100. Frontiers in Immunology. 4: 493. PMID 24416033 DOI: 10.3389/Fimmu.2013.00493 |
0.339 |
|
| 2013 |
Choi SH, Yin H, Ravandi A, Armando A, Dumlao D, Kim J, Almazan F, Taylor AM, McNamara CA, Tsimikas S, Dennis EA, Witztum JL, Miller YI. Polyoxygenated cholesterol ester hydroperoxide activates TLR4 and SYK dependent signaling in macrophages. Plos One. 8: e83145. PMID 24376657 DOI: 10.1371/Journal.Pone.0083145 |
0.445 |
|
| 2013 |
Perry HM, Oldham SN, Fahl SP, Que X, Gonen A, Harmon DB, Tsimikas S, Witztum JL, Bender TP, McNamara CA. Helix-loop-helix factor inhibitor of differentiation 3 regulates interleukin-5 expression and B-1a B cell proliferation. Arteriosclerosis, Thrombosis, and Vascular Biology. 33: 2771-9. PMID 24115031 DOI: 10.1161/Atvbaha.113.302571 |
0.358 |
|
| 2013 |
Montano EN, Boullier A, Almazan F, Binder CJ, Witztum JL, Hartvigsen K. Development and application of a nonradioactive binding assay of oxidized low-density lipoprotein to macrophage scavenger receptors Journal of Lipid Research. 54: 3206-3214. PMID 23997238 DOI: 10.1194/Jlr.D040923 |
0.559 |
|
| 2013 |
Douglas RM, Bowden K, Pattison J, Peterson AB, Juliano J, Dalton ND, Gu Y, Alvarez E, Imamura T, Peterson KL, Witztum JL, Haddad GG, Li AC. Intermittent hypoxia and hypercapnia induce pulmonary artery atherosclerosis and ventricular dysfunction in low density lipoprotein receptor deficient mice. Journal of Applied Physiology (Bethesda, Md. : 1985). 115: 1694-704. PMID 23990245 DOI: 10.1152/Japplphysiol.00442.2013 |
0.329 |
|
| 2013 |
Que X, Widhopf GF, Amir S, Hartvigsen K, Hansen LF, Woelkers D, Tsimikas S, Binder CJ, Kipps TJ, Witztum JL. IGHV1-69-Encoded Antibodies Expressed in Chronic Lymphocytic Leukemia React with Malondialdehyde-Acetaldehyde Adduct, an Immunodominant Oxidation-Specific Epitope Plos One. 8. PMID 23840319 DOI: 10.1371/Journal.Pone.0065203 |
0.553 |
|
| 2013 |
Leibundgut G, Scipione C, Yin H, Schneider M, Boffa MB, Green S, Yang X, Dennis E, Witztum JL, Koschinsky ML, Tsimikas S. Determinants of binding of oxidized phospholipids on apolipoprotein (a) and lipoprotein (a). Journal of Lipid Research. 54: 2815-30. PMID 23828779 DOI: 10.1194/Jlr.M040733 |
0.367 |
|
| 2013 |
Wiesner P, Tafelmeier M, Chittka D, Choi SH, Zhang L, Byun YS, Almazan F, Yang X, Iqbal N, Chowdhury P, Maisel A, Witztum JL, Handel TM, Tsimikas S, Miller YI. MCP-1 binds to oxidized LDL and is carried by lipoprotein(a) in human plasma. Journal of Lipid Research. 54: 1877-83. PMID 23667177 DOI: 10.1194/Jlr.M036343 |
0.401 |
|
| 2013 |
Bertoia ML, Pai JK, Lee JH, Taleb A, Joosten MM, Mittleman MA, Yang X, Witztum JL, Rimm EB, Tsimikas S, Mukamal KJ. Oxidation-specific biomarkers and risk of peripheral artery disease. Journal of the American College of Cardiology. 61: 2169-79. PMID 23541965 DOI: 10.1016/J.Jacc.2013.02.047 |
0.387 |
|
| 2013 |
Leibundgut G, Witztum JL, Tsimikas S. Oxidation-specific epitopes and immunological responses: Translational biotheranostic implications for atherosclerosis. Current Opinion in Pharmacology. 13: 168-79. PMID 23541680 DOI: 10.1016/J.Coph.2013.02.005 |
0.409 |
|
| 2013 |
Lichtman AH, Binder CJ, Tsimikas S, Witztum JL. Adaptive immunity in atherogenesis: new insights and therapeutic approaches. The Journal of Clinical Investigation. 123: 27-36. PMID 23281407 DOI: 10.1172/Jci63108 |
0.557 |
|
| 2013 |
Yoshida H, Shoda T, Yanai H, Ikewaki K, Kurata H, Ito K, Furutani N, Tada N, Witztum JL, Tsimikas S. Effects of pitavastatin and atorvastatin on lipoprotein oxidation biomarkers in patients with dyslipidemia. Atherosclerosis. 226: 161-4. PMID 23174369 DOI: 10.1016/J.Atherosclerosis.2012.10.069 |
0.412 |
|
| 2013 |
Leibundgut G, Scipione C, Yin H, Schneider M, Boffa MB, Green S, Dennis EA, Witztum JL, Koschinsky ML, Tsimikas S. OXIDIZED PHOSPHOLIPIDS ON APOLIPOPROTEIN(A) ARE ONLY PRESENT ON HUMAN LP(A): IMPLICATIONS FOR UNDERSTANDING LP(A) ATHEROGENICS Journal of the American College of Cardiology. 61: E2037. DOI: 10.1016/S0735-1097(13)62037-9 |
0.347 |
|
| 2012 |
Tsimikas S, Willeit P, Willeit J, Santer P, Mayr M, Xu Q, Mayr A, Witztum JL, Kiechl S. Oxidation-specific biomarkers, prospective 15-year cardiovascular and stroke outcomes, and net reclassification of cardiovascular events Journal of the American College of Cardiology. 60: 2218-2229. PMID 23122790 DOI: 10.1016/J.Jacc.2012.08.979 |
0.336 |
|
| 2012 |
Holleboom AG, Daniil G, Fu X, Zhang R, Hovingh GK, Schimmel AW, Kastelein JJ, Stroes ES, Witztum JL, Hutten BA, Tsimikas S, Hazen SL, Chroni A, Kuivenhoven JA. Lipid oxidation in carriers of lecithin:cholesterol acyltransferase gene mutations. Arteriosclerosis, Thrombosis, and Vascular Biology. 32: 3066-75. PMID 23023370 DOI: 10.1161/Atvbaha.112.255711 |
0.404 |
|
| 2012 |
van Dijk RA, Kolodgie F, Ravandi A, Leibundgut G, Hu PP, Prasad A, Mahmud E, Dennis E, Curtiss LK, Witztum JL, Wasserman BA, Otsuka F, Virmani R, Tsimikas S. Differential expression of oxidation-specific epitopes and apolipoprotein(a) in progressing and ruptured human coronary and carotid atherosclerotic lesions. Journal of Lipid Research. 53: 2773-90. PMID 22969153 DOI: 10.1194/Jlr.P030890 |
0.385 |
|
| 2012 |
Thimmulappa RK, Gang X, Kim JH, Sussan TE, Witztum JL, Biswal S. Oxidized phospholipids impair pulmonary antibacterial defenses: evidence in mice exposed to cigarette smoke. Biochemical and Biophysical Research Communications. 426: 253-9. PMID 22935414 DOI: 10.1016/J.Bbrc.2012.08.076 |
0.353 |
|
| 2012 |
Turner WW, Hartvigsen K, Boullier A, Montano EN, Witztum JL, VanNieuwenhze MS. Design and synthesis of a stable oxidized phospholipid mimic with specific binding recognition for macrophage scavenger receptors. Journal of Medicinal Chemistry. 55: 8178-82. PMID 22934615 DOI: 10.1021/Jm300685S |
0.354 |
|
| 2012 |
Purushothaman KR, Purushothaman M, Levy AP, Lento PA, Evrard S, Kovacic JC, Briley-Saebo KC, Tsimikas S, Witztum JL, Krishnan P, Kini A, Fayad ZA, Fuster V, Sharma SK, Moreno PR. Increased expression of oxidation-specific epitopes and apoptosis are associated with haptoglobin genotype: possible implications for plaque progression in human atherosclerosis. Journal of the American College of Cardiology. 60: 112-9. PMID 22766337 DOI: 10.1016/J.Jacc.2012.04.011 |
0.364 |
|
| 2012 |
Visser ME, Witztum JL, Stroes ES, Kastelein JJ. Antisense oligonucleotides for the treatment of dyslipidaemia. European Heart Journal. 33: 1451-8. PMID 22634577 DOI: 10.1093/Eurheartj/Ehs084 |
0.352 |
|
| 2012 |
Arai K, Orsoni A, Mallat Z, Tedgui A, Witztum JL, Bruckert E, Tselepis AD, Chapman MJ, Tsimikas S. Acute impact of apheresis on oxidized phospholipids in patients with familial hypercholesterolemia. Journal of Lipid Research. 53: 1670-8. PMID 22628616 DOI: 10.1194/Jlr.P027235 |
0.381 |
|
| 2012 |
Amir S, Hartvigsen K, Gonen A, Leibundgut G, Que X, Jensen-Jarolim E, Wagner O, Tsimikas S, Witztum JL, Binder CJ. Peptide mimotopes of malondialdehyde epitopes for clinical applications in cardiovascular disease Journal of Lipid Research. 53: 1316-1326. PMID 22508944 DOI: 10.1194/Jlr.M025445 |
0.573 |
|
| 2012 |
Leibundgut G, Arai K, Orsoni A, Yin H, Scipione C, Miller ER, Koschinsky ML, Chapman MJ, Witztum JL, Tsimikas S. Oxidized phospholipids are present on plasminogen, affect fibrinolysis, and increase following acute myocardial infarction. Journal of the American College of Cardiology. 59: 1426-37. PMID 22497821 DOI: 10.1016/J.Jacc.2011.12.033 |
0.383 |
|
| 2012 |
Barish GD, Yu RT, Karunasiri MS, Becerra D, Kim J, Tseng TW, Tai LJ, Leblanc M, Diehl C, Cerchietti L, Miller YI, Witztum JL, Melnick AM, Dent AL, Tangirala RK, et al. The Bcl6-SMRT/NCoR cistrome represses inflammation to attenuate atherosclerosis. Cell Metabolism. 15: 554-62. PMID 22465074 DOI: 10.1016/J.Cmet.2012.02.012 |
0.31 |
|
| 2012 |
Doran AC, Lipinski MJ, Oldham SN, Garmey JC, Campbell KA, Skaflen MD, Cutchins A, Lee DJ, Glover DK, Kelly KA, Galkina EV, Ley K, Witztum JL, Tsimikas S, Bender TP, et al. B-cell aortic homing and atheroprotection depend on Id3. Circulation Research. 110: e1-12. PMID 22034493 DOI: 10.1161/Circresaha.111.256438 |
0.313 |
|
| 2012 |
Ravandi A, Leibundgut G, Hu P, Prasad A, Kolski B, Khadivi B, Patel M, Mahmud E, Miller Y, Dennis E, Witztum J, Tsimikas S. TCT-555 Release of Bioactive Lipids During Percutaneous Coronary, and Peripheral Arterial Interventions in Humans: Lipidomic analysis of Distal Embolic Protection Devices Journal of the American College of Cardiology. 60: B161. DOI: 10.1016/J.Jacc.2012.08.589 |
0.395 |
|
| 2011 |
Fang L, Green SR, Baek JS, Lee SH, Ellett F, Deer E, Lieschke GJ, Witztum JL, Tsimikas S, Miller YI. In vivo visualization and attenuation of oxidized lipid accumulation in hypercholesterolemic zebrafish. The Journal of Clinical Investigation. 121: 4861-9. PMID 22105168 DOI: 10.1172/Jci57755 |
0.435 |
|
| 2011 |
Binder CJ, Witztum JL. Is atherosclerosis an allergic disease? Circulation Research. 109: 1103-4. PMID 22034478 DOI: 10.1161/Res.0B013E31823A8C44 |
0.558 |
|
| 2011 |
Taleb A, Witztum JL, Tsimikas S. Oxidized phospholipids on apoB-100-containing lipoproteins: a biomarker predicting cardiovascular disease and cardiovascular events. Biomarkers in Medicine. 5: 673-94. PMID 22003918 DOI: 10.2217/Bmm.11.60 |
0.455 |
|
| 2011 |
Tsimikas S, Miyanohara A, Hartvigsen K, Merki E, Shaw PX, Chou MY, Pattison J, Torzewski M, Sollors J, Friedmann T, Lai NC, Hammond HK, Getz GS, Reardon CA, Li AC, ... ... Witztum JL, et al. Human oxidation-specific antibodies reduce foam cell formation and atherosclerosis progression. Journal of the American College of Cardiology. 58: 1715-27. PMID 21982317 DOI: 10.1016/J.Jacc.2011.07.017 |
0.422 |
|
| 2011 |
Weismann D, Hartvigsen K, Lauer N, Bennett KL, Scholl HP, Charbel Issa P, Cano M, Brandstätter H, Tsimikas S, Skerka C, Superti-Furga G, Handa JT, Zipfel PF, Witztum JL, Binder CJ. Complement factor H binds malondialdehyde epitopes and protects from oxidative stress. Nature. 478: 76-81. PMID 21979047 DOI: 10.1038/Nature10449 |
0.583 |
|
| 2011 |
Ravandi A, Boekholdt SM, Mallat Z, Talmud PJ, Kastelein JJ, Wareham NJ, Miller ER, Benessiano J, Tedgui A, Witztum JL, Khaw KT, Tsimikas S. Relationship of IgG and IgM autoantibodies and immune complexes to oxidized LDL with markers of oxidation and inflammation and cardiovascular events: results from the EPIC-Norfolk Study. Journal of Lipid Research. 52: 1829-36. PMID 21821825 DOI: 10.1194/Jlr.M015776 |
0.399 |
|
| 2011 |
McMahon M, Skaggs BJ, Sahakian L, Grossman J, FitzGerald J, Ragavendra N, Charles-Schoeman C, Chernishof M, Gorn A, Witztum JL, Wong WK, Weisman M, Wallace DJ, La Cava A, Hahn BH. High plasma leptin levels confer increased risk of atherosclerosis in women with systemic lupus erythematosus, and are associated with inflammatory oxidised lipids. Annals of the Rheumatic Diseases. 70: 1619-24. PMID 21670088 DOI: 10.1136/Ard.2010.142737 |
0.308 |
|
| 2011 |
Haider L, Fischer MT, Frischer JM, Bauer J, Höftberger R, Botond G, Esterbauer H, Binder CJ, Witztum JL, Lassmann H. Oxidative damage in multiple sclerosis lesions. Brain : a Journal of Neurology. 134: 1914-24. PMID 21653539 DOI: 10.1093/Brain/Awr128 |
0.564 |
|
| 2011 |
von Vietinghoff S, Koltsova EK, Mestas J, Diehl CJ, Witztum JL, Ley K. Mycophenolate mofetil decreases atherosclerotic lesion size by depression of aortic T-lymphocyte and interleukin-17-mediated macrophage accumulation. Journal of the American College of Cardiology. 57: 2194-204. PMID 21596236 DOI: 10.1016/J.Jacc.2010.12.030 |
0.329 |
|
| 2011 |
Merki E, Graham M, Taleb A, Leibundgut G, Yang X, Miller ER, Fu W, Mullick AE, Lee R, Willeit P, Crooke RM, Witztum JL, Tsimikas S. Antisense oligonucleotide lowers plasma levels of apolipoprotein (a) and lipoprotein (a) in transgenic mice. Journal of the American College of Cardiology. 57: 1611-21. PMID 21474042 DOI: 10.1016/J.Jacc.2010.10.052 |
0.325 |
|
| 2011 |
Miller YI, Choi SH, Wiesner P, Fang L, Harkewicz R, Hartvigsen K, Boullier A, Gonen A, Diehl CJ, Que X, Montano E, Shaw PX, Tsimikas S, Binder CJ, Witztum JL. Oxidation-specific epitopes are danger-associated molecular patterns recognized by pattern recognition receptors of innate immunity. Circulation Research. 108: 235-48. PMID 21252151 DOI: 10.1161/Circresaha.110.223875 |
0.607 |
|
| 2011 |
Mendez-Fernandez YV, Stevenson BG, Diehl CJ, Braun NA, Wade NS, Covarrubias R, van Leuven S, Witztum JL, Major AS. The inhibitory FcγRIIb modulates the inflammatory response and influences atherosclerosis in male apoE(-/-) mice. Atherosclerosis. 214: 73-80. PMID 21084088 DOI: 10.1016/J.Atherosclerosis.2010.10.018 |
0.381 |
|
| 2011 |
Wool GD, Cabana VG, Lukens J, Shaw PX, Binder CJ, Witztum JL, Reardon CA, Getz GS. 4F Peptide reduces nascent atherosclerosis and induces natural antibody production in apolipoprotein E-null mice. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 290-300. PMID 20876212 DOI: 10.1096/Fj.10-165670 |
0.539 |
|
| 2011 |
Leibundgut G, Arai K, Orsoni A, Miller ER, Koschinsky ML, Chapman JM, Witztum JL. PLASMINOGEN, OXIDIZED PHOSPHOLIPIDS AND ATHEROTHROMBOSIS Journal of the American College of Cardiology. 57: E1559. DOI: 10.1016/S0735-1097(11)61559-3 |
0.364 |
|
| 2010 |
Bishop JR, Passos-Bueno MR, Fong L, Stanford KI, Gonzales JC, Yeh E, Young SG, Bensadoun A, Witztum JL, Esko JD, Moulton KS. Deletion of the basement membrane heparan sulfate proteoglycan type XVIII collagen causes hypertriglyceridemia in mice and humans. Plos One. 5: e13919. PMID 21085708 DOI: 10.1371/Journal.Pone.0013919 |
0.326 |
|
| 2010 |
Steinberg D, Witztum JL. Oxidized low-density lipoprotein and atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology. 30: 2311-6. PMID 21084697 DOI: 10.1161/Atvbaha.108.179697 |
0.436 |
|
| 2010 |
Seimon TA, Nadolski MJ, Liao X, Magallon J, Nguyen M, Feric NT, Koschinsky ML, Harkewicz R, Witztum JL, Tsimikas S, Golenbock D, Moore KJ, Tabas I. Atherogenic lipids and lipoproteins trigger CD36-TLR2-dependent apoptosis in macrophages undergoing endoplasmic reticulum stress. Cell Metabolism. 12: 467-82. PMID 21035758 DOI: 10.1016/J.Cmet.2010.09.010 |
0.361 |
|
| 2010 |
Tsimikas S, Mallat Z, Talmud PJ, Kastelein JJ, Wareham NJ, Sandhu MS, Miller ER, Benessiano J, Tedgui A, Witztum JL, Khaw KT, Boekholdt SM. Oxidation-specific biomarkers, lipoprotein(a), and risk of fatal and nonfatal coronary events. Journal of the American College of Cardiology. 56: 946-55. PMID 20828647 DOI: 10.1016/J.Jacc.2010.04.048 |
0.347 |
|
| 2010 |
Faghihnia N, Tsimikas S, Miller ER, Witztum JL, Krauss RM. Changes in lipoprotein(a), oxidized phospholipids, and LDL subclasses with a low-fat high-carbohydrate diet. Journal of Lipid Research. 51: 3324-30. PMID 20713651 DOI: 10.1194/Jlr.M005769 |
0.357 |
|
| 2010 |
Fang L, Harkewicz R, Hartvigsen K, Wiesner P, Choi SH, Almazan F, Pattison J, Deer E, Sayaphupha T, Dennis EA, Witztum JL, Tsimikas S, Miller YI. Oxidized cholesteryl esters and phospholipids in zebrafish larvae fed a high cholesterol diet: macrophage binding and activation. The Journal of Biological Chemistry. 285: 32343-51. PMID 20710028 DOI: 10.1074/Jbc.M110.137257 |
0.477 |
|
| 2010 |
Sun J, Hartvigsen K, Chou MY, Zhang Y, Sukhova GK, Zhang J, Lopez-Ilasaca M, Diehl CJ, Yakov N, Harats D, George J, Witztum JL, Libby P, Ploegh H, Shi GP. Deficiency of antigen-presenting cell invariant chain reduces atherosclerosis in mice. Circulation. 122: 808-20. PMID 20697023 DOI: 10.1161/Circulationaha.109.891887 |
0.319 |
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| 2010 |
Wiesner P, Choi SH, Almazan F, Benner C, Huang W, Diehl CJ, Gonen A, Butler S, Witztum JL, Glass CK, Miller YI. Low doses of lipopolysaccharide and minimally oxidized low-density lipoprotein cooperatively activate macrophages via nuclear factor kappa B and activator protein-1: possible mechanism for acceleration of atherosclerosis by subclinical endotoxemia. Circulation Research. 107: 56-65. PMID 20489162 DOI: 10.1161/Circresaha.110.218420 |
0.431 |
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| 2010 |
Yvan-Charvet L, Pagler TA, Seimon TA, Thorp E, Welch CL, Witztum JL, Tabas I, Tall AR. ABCA1 and ABCG1 protect against oxidative stress-induced macrophage apoptosis during efferocytosis. Circulation Research. 106: 1861-9. PMID 20431058 DOI: 10.1161/Circresaha.110.217281 |
0.417 |
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| 2010 |
Shao B, Pennathur S, Pagani I, Oda MN, Witztum JL, Oram JF, Heinecke JW. Modifying apolipoprotein A-I by malondialdehyde, but not by an array of other reactive carbonyls, blocks cholesterol efflux by the ABCA1 pathway. The Journal of Biological Chemistry. 285: 18473-84. PMID 20378541 DOI: 10.1074/Jbc.M110.118182 |
0.424 |
|
| 2010 |
Cardilo-Reis L, Witztum JL, Binder CJ. When monocytes come (too) close to our hearts. Journal of the American College of Cardiology. 55: 1639-41. PMID 20378084 DOI: 10.1016/J.Jacc.2009.11.068 |
0.483 |
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| 2010 |
Arai K, Luke MM, Koschinsky ML, Miller ER, Pullinger CR, Witztum JL, Kane JP, Tsimikas S. The I4399M variant of apolipoprotein(a) is associated with increased oxidized phospholipids on apolipoprotein B-100 particles. Atherosclerosis. 209: 498-503. PMID 19880117 DOI: 10.1016/J.Atherosclerosis.2009.09.077 |
0.324 |
|
| 2010 |
Kelly JA, Griffin ME, Fava RA, Wood SG, Bessette KA, Miller ER, Huber SA, Binder CJ, Witztum JL, Morganelli PM. Inhibition of arterial lesion progression in CD16-deficient mice: evidence for altered immunity and the role of IL-10. Cardiovascular Research. 85: 224-31. PMID 19720605 DOI: 10.1093/Cvr/Cvp300 |
0.55 |
|
| 2009 |
Pham T, Gregg CJ, Karp F, Chow R, Padler-Karavani V, Cao H, Chen X, Witztum JL, Varki NM, Varki A. Evidence for a novel human-specific xeno-auto-antibody response against vascular endothelium. Blood. 114: 5225-35. PMID 19828701 DOI: 10.1182/Blood-2009-05-220400 |
0.314 |
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| 2009 |
Stanford KI, Bishop JR, Foley EM, Gonzales JC, Niesman IR, Witztum JL, Esko JD. Syndecan-1 is the primary heparan sulfate proteoglycan mediating hepatic clearance of triglyceride-rich lipoproteins in mice. The Journal of Clinical Investigation. 119: 3236-45. PMID 19805913 DOI: 10.1172/Jci38251 |
0.361 |
|
| 2009 |
Steinberg D, Witztum JL. Inhibition of PCSK9: a powerful weapon for achieving ideal LDL cholesterol levels. Proceedings of the National Academy of Sciences of the United States of America. 106: 9546-7. PMID 19506257 DOI: 10.1073/Pnas.0904560106 |
0.358 |
|
| 2009 |
Fraley AE, Schwartz GG, Olsson AG, Kinlay S, Szarek M, Rifai N, Libby P, Ganz P, Witztum JL, Tsimikas S. Relationship of oxidized phospholipids and biomarkers of oxidized low-density lipoprotein with cardiovascular risk factors, inflammatory biomarkers, and effect of statin therapy in patients with acute coronary syndromes: Results from the MIRACL (Myocardial Ischemia Reduction With Aggressive Cholesterol Lowering) trial. Journal of the American College of Cardiology. 53: 2186-96. PMID 19497447 DOI: 10.1016/J.Jacc.2009.02.041 |
0.401 |
|
| 2009 |
Choi SH, Harkewicz R, Lee JH, Boullier A, Almazan F, Li AC, Witztum JL, Bae YS, Miller YI. Lipoprotein accumulation in macrophages via toll-like receptor-4-dependent fluid phase uptake Circulation Research. 104: 1355-1363. PMID 19461045 DOI: 10.1161/Circresaha.108.192880 |
0.397 |
|
| 2009 |
Gautier EL, Huby T, Saint-Charles F, Ouzilleau B, Pirault J, Deswaerte V, Ginhoux F, Miller ER, Witztum JL, Chapman MJ, Lesnik P. Conventional dendritic cells at the crossroads between immunity and cholesterol homeostasis in atherosclerosis. Circulation. 119: 2367-75. PMID 19380622 DOI: 10.1161/Circulationaha.108.807537 |
0.319 |
|
| 2009 |
Chou MY, Fogelstrand L, Hartvigsen K, Hansen LF, Woelkers D, Shaw PX, Choi J, Perkmann T, Bäckhed F, Miller YI, Hörkkö S, Corr M, Witztum JL, Binder CJ. Oxidation-specific epitopes are dominant targets of innate natural antibodies in mice and humans Journal of Clinical Investigation. 119: 1335-1349. PMID 19363291 DOI: 10.1172/Jci36800 |
0.628 |
|
| 2009 |
Dennis EA, Witztum JL. Fifty years of research on lipids. Journal of Lipid Research. 50: S1. PMID 19346336 DOI: 10.1194/Jlr.Suppeditorial-50/4-Jlr |
0.326 |
|
| 2009 |
Tsimikas S, Clopton P, Brilakis ES, Marcovina SM, Khera A, Miller ER, de Lemos JA, Witztum JL. Relationship of oxidized phospholipids on apolipoprotein B-100 particles to race/ethnicity, apolipoprotein(a) isoform size, and cardiovascular risk factors: results from the Dallas Heart Study. Circulation. 119: 1711-9. PMID 19307470 DOI: 10.1161/Circulationaha.108.836940 |
0.33 |
|
| 2009 |
Stoletov K, Fang L, Choi SH, Hartvigsen K, Hansen LF, Hall C, Pattison J, Juliano J, Miller ER, Almazan F, Crosier P, Witztum JL, Klemke RL, Miller YI. Vascular lipid accumulation, lipoprotein oxidation, and macrophage lipid uptake in hypercholesterolemic zebrafish. Circulation Research. 104: 952-60. PMID 19265037 DOI: 10.1161/Circresaha.108.189803 |
0.386 |
|
| 2009 |
Hartvigsen K, Chou MY, Hansen LF, Shaw PX, Tsimikas S, Binder CJ, Witztum JL. The role of innate immunity in atherogenesis Journal of Lipid Research. 50. PMID 19106070 DOI: 10.1194/Jlr.R800100-Jlr200 |
0.592 |
|
| 2009 |
Bae YS, Lee JH, Choi SH, Kim S, Almazan F, Witztum JL, Miller YI. Macrophages generate reactive oxygen species in response to minimally oxidized low-density lipoprotein: toll-like receptor 4- and spleen tyrosine kinase-dependent activation of NADPH oxidase 2. Circulation Research. 104: 210-8, 21p following. PMID 19096031 DOI: 10.1161/Circresaha.108.181040 |
0.382 |
|
| 2009 |
Tsimikas S, Willeit J, Knoflach M, Mayr M, Egger G, Notdurfter M, Witztum JL, Wiedermann CJ, Xu Q, Kiechl S. Lipoprotein-associated phospholipase A2 activity, ferritin levels, metabolic syndrome, and 10-year cardiovascular and non-cardiovascular mortality: results from the Bruneck study. European Heart Journal. 30: 107-15. PMID 19019993 DOI: 10.1093/Eurheartj/Ehn502 |
0.308 |
|
| 2008 |
Steinberg D, Glass CK, Witztum JL. Evidence mandating earlier and more aggressive treatment of hypercholesterolemia. Circulation. 118: 672-7. PMID 18678783 DOI: 10.1161/Circulationaha.107.753152 |
0.327 |
|
| 2008 |
Merki E, Graham MJ, Mullick AE, Miller ER, Crooke RM, Pitas RE, Witztum JL, Tsimikas S. Antisense oligonucleotide directed to human apolipoprotein B-100 reduces lipoprotein(a) levels and oxidized phospholipids on human apolipoprotein B-100 particles in lipoprotein(a) transgenic mice. Circulation. 118: 743-53. PMID 18663084 DOI: 10.1161/Circulationaha.108.786822 |
0.421 |
|
| 2008 |
Cruz D, Watson AD, Miller CS, Montoya D, Ochoa MT, Sieling PA, Gutierrez MA, Navab M, Reddy ST, Witztum JL, Fogelman AM, Rea TH, Eisenberg D, Berliner J, Modlin RL. Host-derived oxidized phospholipids and HDL regulate innate immunity in human leprosy. The Journal of Clinical Investigation. 118: 2917-28. PMID 18636118 DOI: 10.1172/Jci34189 |
0.376 |
|
| 2008 |
Tsimikas S, Witztum JL. The role of oxidized phospholipids in mediating lipoprotein(a) atherogenicity. Current Opinion in Lipidology. 19: 369-77. PMID 18607184 DOI: 10.1097/Mol.0B013E328308B622 |
0.424 |
|
| 2008 |
Bergmark C, Dewan A, Orsoni A, Merki E, Miller ER, Shin MJ, Binder CJ, Hörkkö S, Krauss RM, Chapman MJ, Witztum JL, Tsimikas S. A novel function of lipoprotein [a] as a preferential carrier of oxidized phospholipids in human plasma. Journal of Lipid Research. 49: 2230-9. PMID 18594118 DOI: 10.1194/Jlr.M800174-Jlr200 |
0.587 |
|
| 2008 |
Choi SH, Chae A, Miller E, Messig M, Ntanios F, DeMaria AN, Nissen SE, Witztum JL, Tsimikas S. Relationship between biomarkers of oxidized low-density lipoprotein, statin therapy, quantitative coronary angiography, and atheroma: volume observations from the REVERSAL (Reversal of Atherosclerosis with Aggressive Lipid Lowering) study. Journal of the American College of Cardiology. 52: 24-32. PMID 18582631 DOI: 10.1016/J.Jacc.2008.02.066 |
0.403 |
|
| 2008 |
Briley-Saebo KC, Shaw PX, Mulder WJ, Choi SH, Vucic E, Aguinaldo JG, Witztum JL, Fuster V, Tsimikas S, Fayad ZA. Targeted molecular probes for imaging atherosclerotic lesions with magnetic resonance using antibodies that recognize oxidation-specific epitopes. Circulation. 117: 3206-15. PMID 18541740 DOI: 10.1161/Circulationaha.107.757120 |
0.411 |
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| 2008 |
Ky B, Burke A, Tsimikas S, Wolfe ML, Tadesse MG, Szapary PO, Witztum JL, FitzGerald GA, Rader DJ. The influence of pravastatin and atorvastatin on markers of oxidative stress in hypercholesterolemic humans. Journal of the American College of Cardiology. 51: 1653-62. PMID 18436117 DOI: 10.1016/J.Jacc.2008.01.026 |
0.434 |
|
| 2008 |
Chou MY, Hartvigsen K, Hansen LF, Fogelstrand L, Shaw PX, Boullier A, Binder CJ, Witztum JL. Oxidation-specific epitopes are important targets of innate immunity Journal of Internal Medicine. 263: 479-488. PMID 18410591 DOI: 10.1111/J.1365-2796.2008.01968.X |
0.612 |
|
| 2008 |
Brunzell JD, Davidson M, Furberg CD, Goldberg RB, Howard BV, Stein JH, Witztum JL. Lipoprotein management in patients with cardiometabolic risk: consensus statement from the American Diabetes Association and the American College of Cardiology Foundation. Diabetes Care. 31: 811-22. PMID 18375431 DOI: 10.2337/Dc08-9018 |
0.351 |
|
| 2008 |
Binder CJ, Chou MY, Fogelstrand L, Hartvigsen K, Shaw PX, Boullier A, Witztum JL. Natural antibodies in murine atherosclerosis Current Drug Targets. 9: 190-195. PMID 18336236 DOI: 10.2174/138945008783755520 |
0.533 |
|
| 2008 |
Harkewicz R, Hartvigsen K, Almazan F, Dennis EA, Witztum JL, Miller YI. Cholesteryl ester hydroperoxides are biologically active components of minimally oxidized low density lipoprotein. The Journal of Biological Chemistry. 283: 10241-51. PMID 18263582 DOI: 10.1074/Jbc.M709006200 |
0.46 |
|
| 2007 |
Binder CJ, Hartvigsen K, Witztum JL. Promise of Immune Modulation to Inhibit Atherogenesis**Editorials published in the Journal of the American College of Cardiology reflect the views of the authors and do not necessarily represent the views of JACC or the American College of Cardiology Journal of the American College of Cardiology. 50: 547-550. PMID 17678739 DOI: 10.1016/J.Jacc.2007.04.054 |
0.537 |
|
| 2007 |
Kiechl S, Willeit J, Mayr M, Viehweider B, Oberhollenzer M, Kronenberg F, Wiedermann CJ, Oberthaler S, Xu Q, Witztum JL, Tsimikas S. Oxidized phospholipids, lipoprotein(a), lipoprotein-associated phospholipase A2 activity, and 10-year cardiovascular outcomes: prospective results from the Bruneck study. Arteriosclerosis, Thrombosis, and Vascular Biology. 27: 1788-95. PMID 17541022 DOI: 10.1161/Atvbaha.107.145805 |
0.356 |
|
| 2007 |
Bro S, Binder CJ, Witztum JL, Olgaard K, Nielsen LB. Inhibition of the renin-angiotensin system abolishes the proatherogenic effect of uremia in apolipoprotein E-deficient mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 27: 1080-6. PMID 17347482 DOI: 10.1161/Atvbaha.107.139634 |
0.507 |
|
| 2007 |
Feng X, Li H, Rumbin AA, Wang X, La Cava A, Brechtelsbauer K, Castellani LW, Witztum JL, Lusis AJ, Tsao BP. ApoE-/-Fas-/- C57BL/6 mice: a novel murine model simultaneously exhibits lupus nephritis, atherosclerosis, and osteopenia. Journal of Lipid Research. 48: 794-805. PMID 17259598 DOI: 10.1194/Jlr.M600512-Jlr200 |
0.358 |
|
| 2007 |
Hartvigsen K, Binder CJ, Hansen LF, Rafia A, Juliano J, Hörkkö S, Steinberg D, Palinski W, Witztum JL, Li AC. A diet-induced hypercholesterolemic murine model to study atherogenesis without obesity and metabolic syndrome Arteriosclerosis, Thrombosis, and Vascular Biology. 27: 878-885. PMID 17255537 DOI: 10.1161/01.Atv.0000258790.35810.02 |
0.561 |
|
| 2007 |
MacArthur JM, Bishop JR, Stanford KI, Wang L, Bensadoun A, Witztum JL, Esko JD. Liver heparan sulfate proteoglycans mediate clearance of triglyceride-rich lipoproteins independently of LDL receptor family members. The Journal of Clinical Investigation. 117: 153-64. PMID 17200715 DOI: 10.1172/Jci29154 |
0.375 |
|
| 2007 |
Tsimikas S, Aikawa M, Miller FJ, Miller ER, Torzewski M, Lentz SR, Bergmark C, Heistad DD, Libby P, Witztum JL. Increased plasma oxidized phospholipid:apolipoprotein B-100 ratio with concomitant depletion of oxidized phospholipids from atherosclerotic lesions after dietary lipid-lowering: a potential biomarker of early atherosclerosis regression. Arteriosclerosis, Thrombosis, and Vascular Biology. 27: 175-81. PMID 17082490 DOI: 10.1161/01.Atv.0000251501.86410.03 |
0.434 |
|
| 2007 |
Holleboom A, Hovingh G, Hutten B, Miller E, Zwinderman A, Groen A, Kastelein J, Witztum J, Kuivenhoven J, Tsimikas S. WO12-OR-6 LECITHIN:CHOLESTEROL ACYLTRANSFERASE AND PROTECTION AGAINST OXIDATIVE MODIFICATION OF LDL IN CARRIERS OF LCAT GENE MUTATIONS Atherosclerosis Supplements. 8: 13. DOI: 10.1016/S1567-5688(07)70994-7 |
0.382 |
|
| 2006 |
Tsimikas S, Brilakis ES, Lennon RJ, Miller ER, Witztum JL, McConnell JP, Kornman KS, Berger PB. Relationship of IgG and IgM autoantibodies to oxidized low density lipoprotein with coronary artery disease and cardiovascular events. Journal of Lipid Research. 48: 425-33. PMID 17093289 DOI: 10.1194/Jlr.M600361-Jlr200 |
0.405 |
|
| 2006 |
Gotsman I, Grabie N, Gupta R, Dacosta R, MacConmara M, Lederer J, Sukhova G, Witztum JL, Sharpe AH, Lichtman AH. Impaired regulatory T-cell response and enhanced atherosclerosis in the absence of inducible costimulatory molecule. Circulation. 114: 2047-55. PMID 17060381 DOI: 10.1161/Circulationaha.106.633263 |
0.312 |
|
| 2006 |
Tuominen A, Miller YI, Hansen LF, Kesäniemi YA, Witztum JL, Hörkkö S. A natural antibody to oxidized cardiolipin binds to oxidized low-density lipoprotein, apoptotic cells, and atherosclerotic lesions. Arteriosclerosis, Thrombosis, and Vascular Biology. 26: 2096-102. PMID 16794225 DOI: 10.1161/01.Atv.0000233333.07991.4A |
0.424 |
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| 2006 |
Mayr M, Kiechl S, Tsimikas S, Miller E, Sheldon J, Willeit J, Witztum JL, Xu Q. Oxidized low-density lipoprotein autoantibodies, chronic infections, and carotid atherosclerosis in a population-based study. Journal of the American College of Cardiology. 47: 2436-43. PMID 16781371 DOI: 10.1016/J.Jacc.2006.03.024 |
0.393 |
|
| 2006 |
Tsimikas S, Kiechl S, Willeit J, Mayr M, Miller ER, Kronenberg F, Xu Q, Bergmark C, Weger S, Oberhollenzer F, Witztum JL. Oxidized phospholipids predict the presence and progression of carotid and femoral atherosclerosis and symptomatic cardiovascular disease: five-year prospective results from the Bruneck study. Journal of the American College of Cardiology. 47: 2219-28. PMID 16750687 DOI: 10.1016/J.Jacc.2006.03.001 |
0.406 |
|
| 2006 |
Rodenburg J, Vissers MN, Wiegman A, Miller ER, Ridker PM, Witztum JL, Kastelein JJ, Tsimikas S. Oxidized low-density lipoprotein in children with familial hypercholesterolemia and unaffected siblings: effect of pravastatin. Journal of the American College of Cardiology. 47: 1803-10. PMID 16682304 DOI: 10.1016/J.Jacc.2005.12.047 |
0.334 |
|
| 2006 |
Boullier A, Li Y, Quehenberger O, Palinski W, Tabas I, Witztum JL, Miller YI. Minimally oxidized LDL offsets the apoptotic effects of extensively oxidized LDL and free cholesterol in macrophages. Arteriosclerosis, Thrombosis, and Vascular Biology. 26: 1169-76. PMID 16484596 DOI: 10.1161/01.Atv.0000210279.97308.9A |
0.435 |
|
| 2006 |
Wilson PW, Ben-Yehuda O, McNamara J, Massaro J, Witztum J, Reaven PD. Autoantibodies to oxidized LDL and cardiovascular risk: the Framingham Offspring Study. Atherosclerosis. 189: 364-8. PMID 16476434 DOI: 10.1016/J.Atherosclerosis.2005.12.013 |
0.39 |
|
| 2006 |
Binder C, Chang M, Boullier A, Chou M, Shaw P, Hartvigsen K, Hansen L, Woelkers D, Miller Y, Hörkkö S, Witztum J. Th-W46:1 Oxidation of LDL leads its recognition by multiple arcs of innate immunity Atherosclerosis Supplements. 7: 459. DOI: 10.1016/S1567-5688(06)81846-5 |
0.569 |
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| 2006 |
Mayr M, Kiechl S, Tsimikas S, Willeit J, Witztum JL, Xu Q. Oxidized LDL autoantibodies, chronic infections and carotid atherosclerosis Vascular Pharmacology. 45: e4. DOI: 10.1016/J.Vph.2006.08.062 |
0.365 |
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| 2005 |
Segev A, Strauss BH, Witztum JL, Lau HK, Tsimikas S. Relationship of a comprehensive panel of plasma oxidized low-density lipoprotein markers to angiographic restenosis in patients undergoing percutaneous coronary intervention for stable angina. American Heart Journal. 150: 1007-14. PMID 16290986 DOI: 10.1016/J.Ahj.2004.12.008 |
0.386 |
|
| 2005 |
Witztum JL. You are right too! The Journal of Clinical Investigation. 115: 2072-5. PMID 16075051 DOI: 10.1172/Jci26130 |
0.345 |
|
| 2005 |
Tsimikas S, Brilakis ES, Miller ER, McConnell JP, Lennon RJ, Kornman KS, Witztum JL, Berger PB. Oxidized phospholipids, Lp(a) lipoprotein, and coronary artery disease. The New England Journal of Medicine. 353: 46-57. PMID 16000355 DOI: 10.1056/Nejmoa043175 |
0.43 |
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| 2005 |
Arakawa H, Qian JY, Baatar D, Karasawa K, Asada Y, Sasaguri Y, Miller ER, Witztum JL, Ueno H. Local expression of platelet-activating factor-acetylhydrolase reduces accumulation of oxidized lipoproteins and inhibits inflammation, shear stress-induced thrombosis, and neointima formation in balloon-injured carotid arteries in nonhyperlipidemic rabbits Circulation. 111: 3302-3309. PMID 15956136 DOI: 10.1161/Circulationaha.104.476242 |
0.32 |
|
| 2005 |
Binder CJ, Shaw PX, Chang MK, Boullier A, Hartvigsen K, Hörkkö S, Miller YI, Woelkers DA, Corr M, Witztum JL. The role of natural antibodies in atherogenesis. Journal of Lipid Research. 46: 1353-63. PMID 15897601 DOI: 10.1194/Jlr.R500005-Jlr200 |
0.573 |
|
| 2005 |
Fahy E, Subramaniam S, Brown HA, Glass CK, Merrill AH, Murphy RC, Raetz CR, Russell DW, Seyama Y, Shaw W, Shimizu T, Spener F, van Meer G, VanNieuwenhze MS, White SH, ... Witztum JL, et al. A comprehensive classification system for lipids. Journal of Lipid Research. 46: 839-61. PMID 15722563 DOI: 10.1194/Jlr.E400004-Jlr200 |
0.326 |
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| 2005 |
Miller YI, Viriyakosol S, Worrall DS, Boullier A, Butler S, Witztum JL. Toll-like receptor 4-dependent and -independent cytokine secretion induced by minimally oxidized low-density lipoprotein in macrophages. Arteriosclerosis, Thrombosis, and Vascular Biology. 25: 1213-9. PMID 15718493 DOI: 10.1161/01.Atv.0000159891.73193.31 |
0.448 |
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| 2005 |
Buono C, Binder CJ, Stavrakis G, Witztum JL, Glimcher LH, Lichtman AH. T-bet deficiency reduces atherosclerosis and alters plaque antigen-specific immune responses. Proceedings of the National Academy of Sciences of the United States of America. 102: 1596-601. PMID 15665085 DOI: 10.1073/Pnas.0409015102 |
0.55 |
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| 2005 |
Schneider M, Witztum JL, Young SG, Ludwig EH, Miller ER, Tsimikas S, Curtiss LK, Marcovina SM, Taylor JM, Lawn RM, Innerarity TL, Pitas RE. High-level lipoprotein [a] expression in transgenic mice: evidence for oxidized phospholipids in lipoprotein [a] but not in low density lipoproteins. Journal of Lipid Research. 46: 769-78. PMID 15654123 DOI: 10.1194/Jlr.M400467-Jlr200 |
0.401 |
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| 2005 |
Frostegård J, Svenungsson E, Wu R, Gunnarsson I, Lundberg IE, Klareskog L, Hörkkö S, Witztum JL. Lipid peroxidation is enhanced in patients with systemic lupus erythematosus and is associated with arterial and renal disease manifestations. Arthritis and Rheumatism. 52: 192-200. PMID 15641060 DOI: 10.1002/Art.20780 |
0.367 |
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| 2004 |
Chang MK, Binder CJ, Miller YI, Subbanagounder G, Silverman GJ, Berliner JA, Witztum JL. Apoptotic cells with oxidation-specific epitopes are immunogenic and proinflammatory. The Journal of Experimental Medicine. 200: 1359-70. PMID 15583011 DOI: 10.1084/Jem.20031763 |
0.62 |
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| 2004 |
Li AC, Binder CJ, Gutierrez A, Brown KK, Plotkin CR, Pattison JW, Valledor AF, Davis RA, Willson TM, Witztum JL, Palinski W, Glass CK. Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARalpha, beta/delta, and gamma. The Journal of Clinical Investigation. 114: 1564-76. PMID 15578089 DOI: 10.1172/Jci18730 |
0.579 |
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| 2004 |
Torzewski M, Shaw PX, Han KR, Shortal B, Lackner KJ, Witztum JL, Palinski W, Tsimikas S. Reduced in vivo aortic uptake of radiolabeled oxidation-specific antibodies reflects changes in plaque composition consistent with plaque stabilization. Arteriosclerosis, Thrombosis, and Vascular Biology. 24: 2307-12. PMID 15528482 DOI: 10.1161/01.Atv.0000149378.98458.Fe |
0.374 |
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| 2004 |
Huo Y, Zhao L, Hyman MC, Shashkin P, Harry BL, Burcin T, Forlow SB, Stark MA, Smith DF, Clarke S, Srinivasan S, Hedrick CC, Praticò D, Witztum JL, Nadler JL, et al. Critical role of macrophage 12/15-lipoxygenase for atherosclerosis in apolipoprotein E-deficient mice. Circulation. 110: 2024-31. PMID 15451785 DOI: 10.1161/01.Cir.0000143628.37680.F6 |
0.353 |
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| 2004 |
Schneider M, Vergès B, Klein A, Miller ER, Deckert V, Desrumaux C, Masson D, Gambert P, Brun JM, Fruchart-Najib J, Blache D, Witztum JL, Lagrost L. Alterations in plasma vitamin E distribution in type 2 diabetic patients with elevated plasma phospholipid transfer protein activity. Diabetes. 53: 2633-9. PMID 15448094 DOI: 10.2337/Diabetes.53.10.2633 |
0.316 |
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| 2004 |
Tsimikas S, Witztum JL, Miller ER, Sasiela WJ, Szarek M, Olsson AG, Schwartz GG. High-dose atorvastatin reduces total plasma levels of oxidized phospholipids and immune complexes present on apolipoprotein B-100 in patients with acute coronary syndromes in the MIRACL trial. Circulation. 110: 1406-12. PMID 15353498 DOI: 10.1161/01.Cir.0000141728.23033.B5 |
0.406 |
|
| 2004 |
Choudhury RP, Rong JX, Trogan E, Elmalem VI, Dansky HM, Breslow JL, Witztum JL, Fallon JT, Fisher EA. High-density lipoproteins retard the progression of atherosclerosis and favorably remodel lesions without suppressing indices of inflammation or oxidation. Arteriosclerosis, Thrombosis, and Vascular Biology. 24: 1904-9. PMID 15319266 DOI: 10.1161/01.Atv.0000142808.34602.25 |
0.436 |
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| 2004 |
Kris-Etherton PM, Lichtenstein AH, Howard BV, Steinberg D, Witztum JL. Antioxidant vitamin supplements and cardiovascular disease Circulation. 110: 637-641. PMID 15289389 DOI: 10.1161/01.Cir.0000137822.39831.F1 |
0.321 |
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| 2004 |
Binder CJ, Hartvigsen K, Chang MK, Miller M, Broide D, Palinski W, Curtiss LK, Corr M, Witztum JL. IL-5 links adaptive and natural immunity specific for epitopes of oxidized LDL and protects from atherosclerosis. The Journal of Clinical Investigation. 114: 427-37. PMID 15286809 DOI: 10.1172/Jci20479 |
0.596 |
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| 2004 |
Tsimikas S, Lau HK, Han KR, Shortal B, Miller ER, Segev A, Curtiss LK, Witztum JL, Strauss BH. Percutaneous coronary intervention results in acute increases in oxidized phospholipids and lipoprotein(a): short-term and long-term immunologic responses to oxidized low-density lipoprotein. Circulation. 109: 3164-70. PMID 15184281 DOI: 10.1161/01.Cir.0000130844.01174.55 |
0.424 |
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| 2004 |
Reardon CA, Miller ER, Blachowicz L, Lukens J, Binder CJ, Witztum JL, Getz GS. Autoantibodies to OxLDL fail to alter the clearance of injected OxLDL in apolipoprotein E-deficient mice. Journal of Lipid Research. 45: 1347-54. PMID 15102879 DOI: 10.1194/Jlr.M400075-Jlr200 |
0.625 |
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| 2004 |
Rock CL, Flatt SW, Thomson CA, Stefanick ML, Newman VA, Jones L, Natarajan L, Pierce JP, Chang RJ, Witztum JL. Plasma triacylglycerol and HDL cholesterol concentrations confirm self-reported changes in carbohydrate and fat intakes in women in a diet intervention trial. The Journal of Nutrition. 134: 342-7. PMID 14747670 DOI: 10.1093/Jn/134.2.342 |
0.328 |
|
| 2004 |
Silaste ML, Rantala M, Alfthan G, Aro A, Witztum JL, Kesäniemi YA, Hörkkö S. Changes in dietary fat intake alter plasma levels of oxidized low-density lipoprotein and lipoprotein(a). Arteriosclerosis, Thrombosis, and Vascular Biology. 24: 498-503. PMID 14739118 DOI: 10.1161/01.Atv.0000118012.64932.F4 |
0.417 |
|
| 2004 |
Frostegård J, Wu R, Lemne C, Thulin T, Witztum JL, de Faire U. Circulating oxidized low-density lipoprotein is increased in hypertension. Clinical Science (London, England : 1979). 105: 615-20. PMID 12837127 DOI: 10.1042/Cs20030152 |
0.379 |
|
| 2004 |
Tsimikas S, Glass CK, Steinberg D, Witztum JL. Lipoprotein Oxidation, Macrophages, Immunity, and Atherogenesis Molecular Basis of Cardiovascular Disease: a Companion to Braunwald's Heart Disease. 385-413. DOI: 10.1016/B978-0-7216-9428-3.50027-5 |
0.316 |
|
| 2003 |
Edelstein C, Pfaffinger D, Hinman J, Miller E, Lipkind G, Tsimikas S, Bergmark C, Getz GS, Witztum JL, Scanu AM. Lysine-phosphatidylcholine adducts in kringle V impart unique immunological and potential pro-inflammatory properties to human apolipoprotein(a). The Journal of Biological Chemistry. 278: 52841-7. PMID 14557258 DOI: 10.1074/Jbc.M310425200 |
0.35 |
|
| 2003 |
Miller YI, Worrall DS, Funk CD, Feramisco JR, Witztum JL. Actin polymerization in macrophages in response to oxidized LDL and apoptotic cells: role of 12/15-lipoxygenase and phosphoinositide 3-kinase. Molecular Biology of the Cell. 14: 4196-206. PMID 14517329 DOI: 10.1091/Mbc.E03-02-0063 |
0.388 |
|
| 2003 |
Miller YI, Chang MK, Binder CJ, Shaw PX, Witztum JL. Oxidized low density lipoprotein and innate immune receptors. Current Opinion in Lipidology. 14: 437-45. PMID 14501582 DOI: 10.1097/00041433-200310000-00004 |
0.599 |
|
| 2003 |
Engler MM, Engler MB, Malloy MJ, Chiu EY, Schloetter MC, Paul SM, Stuehlinger M, Lin KY, Cooke JP, Morrow JD, Ridker PM, Rifai N, Miller E, Witztum JL, Mietus-Snyder M. Antioxidant vitamins C and E improve endothelial function in children with hyperlipidemia: Endothelial Assessment of Risk from Lipids in Youth (EARLY) Trial. Circulation. 108: 1059-63. PMID 12912807 DOI: 10.1161/01.Cir.0000086345.09861.A0 |
0.335 |
|
| 2003 |
Shaw PX, Goodyear CS, Chang MK, Witztum JL, Silverman GJ. The autoreactivity of anti-phosphorylcholine antibodies for atherosclerosis-associated neo-antigens and apoptotic cells. Journal of Immunology (Baltimore, Md. : 1950). 170: 6151-7. PMID 12794145 DOI: 10.4049/Jimmunol.170.12.6151 |
0.382 |
|
| 2003 |
Binder CJ, Hörkkö S, Dewan A, Chang MK, Kieu EP, Goodyear CS, Shaw PX, Palinski W, Witztum JL, Silverman GJ. Pneumococcal vaccination decreases atherosclerotic lesion formation: molecular mimicry between Streptococcus pneumoniae and oxidized LDL. Nature Medicine. 9: 736-43. PMID 12740573 DOI: 10.1016/S0214-9168(03)78944-X |
0.616 |
|
| 2003 |
Sukhova GK, Zhang Y, Pan JH, Wada Y, Yamamoto T, Naito M, Kodama T, Tsimikas S, Witztum JL, Lu ML, Sakara Y, Chin MT, Libby P, Shi GP. Deficiency of cathepsin S reduces atherosclerosis in LDL receptor-deficient mice. The Journal of Clinical Investigation. 111: 897-906. PMID 12639996 DOI: 10.1172/Jci14915 |
0.361 |
|
| 2003 |
Tsimikas S, Bergmark C, Beyer RW, Patel R, Pattison J, Miller E, Juliano J, Witztum JL. Temporal increases in plasma markers of oxidized low-density lipoprotein strongly reflect the presence of acute coronary syndromes. Journal of the American College of Cardiology. 41: 360-70. PMID 12575961 DOI: 10.1016/S0735-1097(02)02769-9 |
0.37 |
|
| 2003 |
Miller YI, Viriyakosol S, Binder CJ, Feramisco JR, Kirkland TN, Witztum JL. Minimally modified LDL binds to CD14, induces macrophage spreading via TLR4/MD-2, and inhibits phagocytosis of apoptotic cells. The Journal of Biological Chemistry. 278: 1561-8. PMID 12424240 DOI: 10.1074/Jbc.M209634200 |
0.574 |
|
| 2003 |
Binder CJ, Witztum JL. Reply to "Humoral immunity and atherosclerosis" Nature Medicine. 9: 244-245. DOI: 10.1038/Nm0303-244 |
0.523 |
|
| 2003 |
Svenungsson E, Fei G, Gunnarsson I, Lundberg I, Wu R, Witztum J, Frostegard J. 4P-1105 TNF-alpha, dyslipoproteinemia and LDL oxidation are risk factors for CVD in SLE Atherosclerosis Supplements. 4: 317. DOI: 10.1016/S1567-5688(03)91361-4 |
0.314 |
|
| 2003 |
Bergmark C, Tsimikas S, Kuroe K, Miller E, Witztum J. 4P-0970 Phosphorylcholine containing oxidized phospholipids, detected by monoclonal antibody EO6, are transported by Lp(a): A novel function for Ip(a) Atherosclerosis Supplements. 4: 287. DOI: 10.1016/S1567-5688(03)91228-1 |
0.341 |
|
| 2003 |
Tsimikas S, Lau HK, Han K, Miller ER, Juliano J, Witztum JL, Strauss BH. Mechanical disruption of atherosclerotic plaques during percutaneous coronary intervention results in acute plasma increases in oxidized low-density lipoprotein and Lp(a): Implications for understanding vulnerable plaques Journal of the American College of Cardiology. 41: 239. DOI: 10.1016/S0735-1097(03)81697-2 |
0.388 |
|
| 2003 |
Tsimikas S, Torzewski M, Shortal B, Palinski W, Witztum JL. Preferential uptake of radiolabeled oxidation-specific antibodies in lipid-rich versus collagen-rich lesions: Implications for noninvasive imaging of vulnerable plaques Journal of the American College of Cardiology. 41: 445. DOI: 10.1016/S0735-1097(03)81354-2 |
0.376 |
|
| 2002 |
Fang JC, Kinlay S, Behrendt D, Hikita H, Witztum JL, Selwyn AP, Ganz P. Circulating autoantibodies to oxidized LDL correlate with impaired coronary endothelial function after cardiac transplantation. Arteriosclerosis, Thrombosis, and Vascular Biology. 22: 2044-8. PMID 12482832 DOI: 10.1161/01.Atv.0000040854.47020.44 |
0.394 |
|
| 2002 |
Binder CJ, Chang MK, Shaw PX, Miller YI, Hartvigsen K, Dewan A, Witztum JL. Innate and acquired immunity in atherogenesis. Nature Medicine. 8: 1218-26. PMID 12411948 DOI: 10.1038/Nm1102-1218 |
0.529 |
|
| 2002 |
Chang MK, Binder CJ, Torzewski M, Witztum JL. C-reactive protein binds to both oxidized LDL and apoptotic cells through recognition of a common ligand: Phosphorylcholine of oxidized phospholipids. Proceedings of the National Academy of Sciences of the United States of America. 99: 13043-8. PMID 12244213 DOI: 10.1073/Pnas.192399699 |
0.601 |
|
| 2002 |
Aikawa M, Sugiyama S, Hill CC, Voglic SJ, Rabkin E, Fukumoto Y, Schoen FJ, Witztum JL, Libby P. Lipid lowering reduces oxidative stress and endothelial cell activation in rabbit atheroma. Circulation. 106: 1390-6. PMID 12221058 DOI: 10.1161/01.Cir.0000028465.52694.9B |
0.395 |
|
| 2002 |
Jiang XC, Tall AR, Qin S, Lin M, Schneider M, Lalanne F, Deckert V, Desrumaux C, Athias A, Witztum JL, Lagrost L. Phospholipid transfer protein deficiency protects circulating lipoproteins from oxidation due to the enhanced accumulation of vitamin E. The Journal of Biological Chemistry. 277: 31850-6. PMID 12105225 DOI: 10.1074/Jbc.M205077200 |
0.408 |
|
| 2002 |
Steinberg D, Witztum JL. Is the oxidative modification hypothesis relevant to human atherosclerosis? Do the antioxidant trials conducted to date refute the hypothesis? Circulation. 105: 2107-2111. PMID 11980692 DOI: 10.1161/01.Cir.0000014762.06201.06 |
0.343 |
|
| 2002 |
Witztum JL. Splenic immunity and atherosclerosis: a glimpse into a novel paradigm? The Journal of Clinical Investigation. 109: 721-4. PMID 11901180 DOI: 10.1172/Jci15310 |
0.355 |
|
| 2002 |
Huber J, Vales A, Mitulovic G, Blumer M, Schmid R, Witztum JL, Binder BR, Leitinger N. Oxidized membrane vesicles and blebs from apoptotic cells contain biologically active oxidized phospholipids that induce monocyte-endothelial interactions. Arteriosclerosis, Thrombosis, and Vascular Biology. 22: 101-7. PMID 11788468 DOI: 10.1161/Hq0102.101525 |
0.412 |
|
| 2002 |
Subbanagounder G, Wong JW, Lee H, Faull KF, Miller E, Witztum JL, Berliner JA. Epoxyisoprostane and epoxycyclopentenone phospholipids regulate monocyte chemotactic protein-1 and interleukin-8 synthesis. Formation of these oxidized phospholipids in response to interleukin-1beta. The Journal of Biological Chemistry. 277: 7271-81. PMID 11751881 DOI: 10.1074/Jbc.M107602200 |
0.341 |
|
| 2002 |
Friedman P, Horkko S, Steinberg D, Witztum JL, Dennis EA. Correlation of antiphospholipid antibody recognition with the structure of synthetic oxidized phospholipids. Importance of Schiff base formation and aldol condensation. The Journal of Biological Chemistry. 277: 7010-20. PMID 11744722 DOI: 10.1074/Jbc.M108860200 |
0.418 |
|
| 2001 |
Boullier A, Bird DA, Chang MK, Dennis EA, Friedman P, Gillotre-Taylor K, Hörkkö S, Palinski W, Quehenberger O, Shaw P, Steinberg D, Terpstra V, Witztum JL. Scavenger receptors, oxidized LDL, and atherosclerosis. Annals of the New York Academy of Sciences. 947: 214-22; discussion 2. PMID 11795269 DOI: 10.1111/J.1749-6632.2001.Tb03943.X |
0.446 |
|
| 2001 |
Palinski W, D'Armiento FP, Witztum JL, de Nigris F, Casanada F, Condorelli M, Silvestre M, Napoli C. Maternal hypercholesterolemia and treatment during pregnancy influence the long-term progression of atherosclerosis in offspring of rabbits. Circulation Research. 89: 991-6. PMID 11717155 DOI: 10.1161/Hh2301.099646 |
0.316 |
|
| 2001 |
Witztum JL, Steinberg D. The oxidative modification hypothesis of atherosclerosis: Does it hold for humans? Trends in Cardiovascular Medicine. 11: 93-102. PMID 11686009 DOI: 10.1016/S1050-1738(01)00111-6 |
0.414 |
|
| 2001 |
Shaw PX, Hörkkö S, Tsimikas S, Chang MK, Palinski W, Silverman GJ, Chen PP, Witztum JL. Human-derived anti-oxidized LDL autoantibody blocks uptake of oxidized LDL by macrophages and localizes to atherosclerotic lesions in vivo. Arteriosclerosis, Thrombosis, and Vascular Biology. 21: 1333-9. PMID 11498462 DOI: 10.1161/Hq0801.093587 |
0.469 |
|
| 2001 |
Laurila A, Cole SP, Merat S, Obonyo M, Palinski W, Fierer J, Witztum JL. High-fat, high-cholesterol diet increases the incidence of gastritis in LDL receptor-negative mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 21: 991-6. PMID 11397709 DOI: 10.1161/01.Atv.21.6.991 |
0.349 |
|
| 2001 |
Cyrus T, Praticò D, Zhao L, Witztum JL, Rader DJ, Rokach J, FitzGerald GA, Funk CD. Absence of 12/15-lipoxygenase expression decreases lipid peroxidation and atherogenesis in apolipoprotein e-deficient mice. Circulation. 103: 2277-82. PMID 11342477 DOI: 10.1161/01.Cir.103.18.2277 |
0.439 |
|
| 2001 |
Tsimikas S, Witztum JL. Measuring circulating oxidized low-density lipoprotein to evaluate coronary risk. Circulation. 103: 1930-2. PMID 11306518 DOI: 10.1161/01.Cir.103.15.1930 |
0.472 |
|
| 2001 |
Miller YI, Chang MK, Funk CD, Feramisco JR, Witztum JL. 12/15-lipoxygenase translocation enhances site-specific actin polymerization in macrophages phagocytosing apoptotic cells. The Journal of Biological Chemistry. 276: 19431-9. PMID 11278875 DOI: 10.1074/Jbc.M011276200 |
0.324 |
|
| 2001 |
Hörkkö S, Olee T, Mo L, Branch DW, Woods VL, Palinski W, Chen PP, Witztum JL. Anticardiolipin antibodies from patients with the antiphospholipid antibody syndrome recognize epitopes in both beta(2)-glycoprotein 1 and oxidized low-density lipoprotein. Circulation. 103: 941-6. PMID 11181467 DOI: 10.1161/01.Cir.103.7.941 |
0.329 |
|
| 2001 |
Praticò D, Tangirala RK, Hörkkö S, Witztum JL, Palinski W, FitzGerald GA. Circulating autoantibodies to oxidized cardiolipin correlate with isoprostane F(2alpha)-VI levels and the extent of atherosclerosis in ApoE-deficient mice: modulation by vitamin E. Blood. 97: 459-64. PMID 11154223 DOI: 10.1182/Blood.V97.2.459 |
0.398 |
|
| 2001 |
Tsimikas S, Palinski W, Witztum JL. Circulating autoantibodies to oxidized LDL correlate with arterial accumulation and depletion of oxidized LDL in LDL receptor-deficient mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 21: 95-100. PMID 11145939 DOI: 10.1161/01.Atv.21.1.95 |
0.402 |
|
| 2001 |
Frostegard J, Svenungsson E, Jensen-Urstad K, Heimburger M, Klareskog L, Hamsten A, Faire UD, Witztum J. FRI0127 Atherosclerosis and arterial disease in systemic lupus erythematosus Annals of the Rheumatic Diseases. 60. DOI: 10.1136/Annrheumdis-2001.162 |
0.327 |
|
| 2000 |
Napoli C, Witztum JL, Calara F, de Nigris F, Palinski W. Maternal hypercholesterolemia enhances atherogenesis in normocholesterolemic rabbits, which is inhibited by antioxidant or lipid-lowering intervention during pregnancy: an experimental model of atherogenic mechanisms in human fetuses. Circulation Research. 87: 946-52. PMID 11073892 DOI: 10.1161/01.Res.87.10.946 |
0.321 |
|
| 2000 |
Hörkkö S, Binder CJ, Shaw PX, Chang MK, Silverman G, Palinski W, Witztum JL. Immunological responses to oxidized LDL. Free Radical Biology & Medicine. 28: 1771-9. PMID 10946219 DOI: 10.1016/S0891-5849(00)00333-6 |
0.606 |
|
| 2000 |
Hedrick CC, Hassan K, Hough GP, Yoo JH, Simzar S, Quinto CR, Kim SM, Dooley A, Langi S, Hama SY, Navab M, Witztum JL, Fogelman AM. Short-term feeding of atherogenic diet to mice results in reduction of HDL and paraoxonase that may be mediated by an immune mechanism. Arteriosclerosis, Thrombosis, and Vascular Biology. 20: 1946-52. PMID 10938016 DOI: 10.1161/01.Atv.20.8.1946 |
0.368 |
|
| 2000 |
Shaw PX, Hörkkö S, Chang MK, Curtiss LK, Palinski W, Silverman GJ, Witztum JL. Natural antibodies with the T15 idiotype may act in atherosclerosis, apoptotic clearance, and protective immunity. The Journal of Clinical Investigation. 105: 1731-40. PMID 10862788 DOI: 10.1172/Jci8472 |
0.443 |
|
| 2000 |
Palinski W, Witztum JL. Immune responses to oxidative neoepitopes on LDL and phospholipids modulate the development of atherosclerosis. Journal of Internal Medicine. 247: 371-80. PMID 10762454 DOI: 10.1046/J.1365-2796.2000.00656.X |
0.458 |
|
| 2000 |
Shih DM, Xia YR, Wang XP, Miller E, Castellani LW, Subbanagounder G, Cheroutre H, Faull KF, Berliner JA, Witztum JL, Lusis AJ. Combined serum paraoxonase knockout/apolipoprotein E knockout mice exhibit increased lipoprotein oxidation and atherosclerosis Journal of Biological Chemistry. 275: 17527-17535. PMID 10748217 DOI: 10.1074/Jbc.M910376199 |
0.313 |
|
| 2000 |
Boullier A, Gillotte KL, Hörkkö S, Green SR, Friedman P, Dennis EA, Witztum JL, Steinberg D, Quehenberger O. The binding of oxidized low density lipoprotein to mouse CD36 is mediated in part by oxidized phospholipids that are associated with both the lipid and protein moieties of the lipoprotein. The Journal of Biological Chemistry. 275: 9163-9. PMID 10734051 DOI: 10.1074/Jbc.275.13.9163 |
0.38 |
|
| 2000 |
Tsimikas S, Shortal BP, Witztum JL, Palinski W. In vivo uptake of radiolabeled MDA2, an oxidation-specific monoclonal antibody, provides an accurate measure of atherosclerotic lesions rich in oxidized LDL and is highly sensitive to their regression. Arteriosclerosis, Thrombosis, and Vascular Biology. 20: 689-97. PMID 10712392 DOI: 10.1161/01.Atv.20.3.689 |
0.386 |
|
| 2000 |
Gillotte-Taylor K, Boullier A, Kim C, Quehenberger O, Witztum J, Steinberg D. Scavenger receptor type B, class 1 (SR-B1) as a receptor for oxidized low density lipoprotein (OxLDL) Atherosclerosis. 151: 298-299. DOI: 10.1016/S0021-9150(00)81357-X |
0.35 |
|
| 2000 |
Palinski W, Hörkkö S, Shaw P, Tsimikas S, Silverman G, Witztum J. Biological significance of autoantibodies to oxidative neoepitopes Atherosclerosis. 151: 165. DOI: 10.1016/S0021-9150(00)80749-2 |
0.358 |
|
| 2000 |
Tsimikas S, Palinski W, Shaw P, Witztum J. Noninvasive imaging and quantitation of atherosclerosis with radiolabeled oxidation-specific antibodies Atherosclerosis. 151: 4-5. DOI: 10.1016/S0021-9150(00)80019-2 |
0.345 |
|
| 2000 |
Tsimikas S, Witztum JL. The Oxidative Modification Hypothesis of Atherogenesis Trends in Cardiovascular Medicine. 11: 49-74. DOI: 10.1007/978-1-4615-4649-8_4 |
0.413 |
|
| 1999 |
Huang JT, Welch JS, Ricote M, Binder CJ, Willson TM, Kelly C, Witztum JL, Funk CD, Conrad D, Glass CK. Interleukin-4-dependent production of PPAR-gamma ligands in macrophages by 12/15-lipoxygenase. Nature. 400: 378-82. PMID 10432118 DOI: 10.1038/22572 |
0.533 |
|
| 1999 |
Lee C, Sigari F, Segrado T, Hörkkö S, Hama S, Subbaiah PV, Miwa M, Navab M, Witztum JL, Reaven PD. All ApoB-containing lipoproteins induce monocyte chemotaxis and adhesion when minimally modified. Modulation of lipoprotein bioactivity by platelet-activating factor acetylhydrolase. Arteriosclerosis, Thrombosis, and Vascular Biology. 19: 1437-46. PMID 10364074 DOI: 10.1161/01.Atv.19.6.1437 |
0.449 |
|
| 1999 |
Cyrus T, Witztum JL, Rader DJ, Tangirala R, Fazio S, Linton MF, Funk CD. Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E-deficient mice. The Journal of Clinical Investigation. 103: 1597-604. PMID 10359569 DOI: 10.1172/Jci5897 |
0.421 |
|
| 1999 |
Chang MK, Bergmark C, Laurila A, Hörkkö S, Han KH, Friedman P, Dennis EA, Witztum JL. Monoclonal antibodies against oxidized low-density lipoprotein bind to apoptotic cells and inhibit their phagocytosis by elicited macrophages: evidence that oxidation-specific epitopes mediate macrophage recognition. Proceedings of the National Academy of Sciences of the United States of America. 96: 6353-8. PMID 10339591 DOI: 10.1073/Pnas.96.11.6353 |
0.428 |
|
| 1999 |
Bird DA, Gillotte KL, Horkko S, Friedman P, Dennis EA, Witztum JL, Steinberg D. Receptors for oxidized low-density lipoprotein on elicited mouse peritoneal macrophages can recognize both the modified lipid moieties and the modified protein moieties: Implications with respect to macrophage recognition of apoptotic cells Proceedings of the National Academy of Sciences of the United States of America. 96: 6347-6352. PMID 10339590 DOI: 10.1073/Pnas.96.11.6347 |
0.445 |
|
| 1999 |
Tsimikas S, Palinski W, Halpern SE, Yeung DW, Curtiss LK, Witztum JL. Radiolabeled MDA2, an oxidation-specific, monoclonal antibody, identifies native atherosclerotic lesions in vivo. Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology. 6: 41-53. PMID 10070840 DOI: 10.1016/S1071-3581(99)90064-8 |
0.397 |
|
| 1999 |
Wu R, de Faire U, Lemne C, Witztum JL, Frostegård J. Autoantibodies to OxLDL are decreased in individuals with borderline hypertension. Hypertension (Dallas, Tex. : 1979). 33: 53-9. PMID 9931081 DOI: 10.1161/01.Hyp.33.1.53 |
0.371 |
|
| 1999 |
Hörkkö S, Bird DA, Miller E, Itabe H, Leitinger N, Subbanagounder G, Berliner JA, Friedman P, Dennis EA, Curtiss LK, Palinski W, Witztum JL. Monoclonal autoantibodies specific for oxidized phospholipids or oxidized phospholipid-protein adducts inhibit macrophage uptake of oxidized low-density lipoproteins. The Journal of Clinical Investigation. 103: 117-28. PMID 9884341 DOI: 10.1172/Jci4533 |
0.462 |
|
| 1999 |
Witztum JL. To E or not to E--how do we tell? Circulation. 98: 2785-7. PMID 9860775 DOI: 10.1161/01.Cir.98.25.2785 |
0.452 |
|
| 1999 |
Freigang S, Hörkkö S, Miller E, Witztum JL, Palinski W. Immunization of LDL receptor-deficient mice with homologous malondialdehyde-modified and native LDL reduces progression of atherosclerosis by mechanisms other than induction of high titers of antibodies to oxidative neoepitopes. Arteriosclerosis, Thrombosis, and Vascular Biology. 18: 1972-82. PMID 9848892 DOI: 10.1161/01.Atv.18.12.1972 |
0.475 |
|
| 1998 |
Witztum JL, Berliner JA. Oxidized phospholipids and isoprostanes in atherosclerosis Current Opinion in Lipidology. 9: 441-448. PMID 9812198 DOI: 10.1097/00041433-199810000-00008 |
0.426 |
|
| 1998 |
Ricote M, Huang J, Fajas L, Li A, Welch J, Najib J, Witztum JL, Auwerx J, Palinski W, Glass CK. Expression of the peroxisome proliferator-activated receptor gamma (PPARgamma) in human atherosclerosis and regulation in macrophages by colony stimulating factors and oxidized low density lipoprotein. Proceedings of the National Academy of Sciences of the United States of America. 95: 7614-9. PMID 9636198 DOI: 10.1073/Pnas.95.13.7614 |
0.37 |
|
| 1998 |
Calara F, Dimayuga P, Niemann A, Thyberg J, Diczfalusy U, Witztum JL, Palinski W, Shah PK, Cercek B, Nilsson J, Regnström J. An animal model to study local oxidation of LDL and its biological effects in the arterial wall. Arteriosclerosis, Thrombosis, and Vascular Biology. 18: 884-93. PMID 9633927 DOI: 10.1161/01.Atv.18.6.884 |
0.43 |
|
| 1998 |
Sigari F, Lee C, Witztum JL, Reaven PD. Fibroblasts that overexpress 15-lipoxygenase generate bioactive and minimally modified LDL. Arteriosclerosis, Thrombosis, and Vascular Biology. 17: 3639-45. PMID 9437216 DOI: 10.1161/01.Atv.17.12.3639 |
0.458 |
|
| 1998 |
Napoli C, D'Armiento FP, Mancini FP, Postiglione A, Witztum JL, Palumbo G, Palinski W. Fatty streak formation occurs in human fetal aortas and is greatly enhanced by maternal hypercholesterolemia. Intimal accumulation of low density lipoprotein and its oxidation precede monocyte recruitment into early atherosclerotic lesions. The Journal of Clinical Investigation. 100: 2680-90. PMID 9389731 DOI: 10.1172/JCI119813 |
0.326 |
|
| 1997 |
Horie K, Miyata T, Maeda K, Miyata S, Sugiyama S, Sakai H, Van Ypersele De Strihou C, Monnier VM, Witztum JL, Kurokawa K. Immunohistochemical colocalization of glycoxidation products and lipid peroxidation products in diabetic renal glomerular lesions. Implication for glycoxidative stress in the pathogenesis of diabetic nephropathy Journal of Clinical Investigation. 100: 2995-3004. PMID 9399945 DOI: 10.1172/Jci119853 |
0.304 |
|
| 1997 |
Scheidegger KJ, Butler S, Witztum JL. Angiotensin II increases macrophage-mediated modification of low density lipoprotein via a lipoxygenase-dependent pathway. The Journal of Biological Chemistry. 272: 21609-15. PMID 9261183 DOI: 10.1074/Jbc.272.34.21609 |
0.318 |
|
| 1997 |
Witztum JL. Immunological response to oxidized LDL. Atherosclerosis. S9-11. PMID 9253468 DOI: 10.1016/S0021-9150(97)06116-9 |
0.403 |
|
| 1997 |
Witztum JL, Hörkkö S. The role of oxidized LDL in atherogenesis: immunological response and anti-phospholipid antibodies. Annals of the New York Academy of Sciences. 811: 88-96; discussion 96. PMID 9186588 DOI: 10.1111/J.1749-6632.1997.Tb51992.X |
0.404 |
|
| 1997 |
Watson AD, Leitinger N, Navab M, Faull KF, Hörkkö S, Witztum JL, Palinski W, Schwenke D, Salomon RG, Sha W, Subbanagounder G, Fogelman AM, Berliner JA. Structural identification by mass spectrometry of oxidized phospholipids in minimally oxidized low density lipoprotein that induce monocyte/endothelial interactions and evidence for their presence in vivo. The Journal of Biological Chemistry. 272: 13597-607. PMID 9153208 DOI: 10.1074/Jbc.272.21.13597 |
0.447 |
|
| 1996 |
Reaven PD, Witztum JL. Oxidized low density lipoproteins in atherogenesis: role of dietary modification. Annual Review of Nutrition. 16: 51-71. PMID 8839919 DOI: 10.1146/Annurev.Nu.16.070196.000411 |
0.419 |
|
| 1996 |
Hörkkö S, Miller E, Dudl E, Reaven P, Curtiss LK, Zvaifler NJ, Terkeltaub R, Pierangeli SS, Branch DW, Palinski W, Witztum JL. Antiphospholipid antibodies are directed against epitopes of oxidized phospholipids. Recognition of cardiolipin by monoclonal antibodies to epitopes of oxidized low density lipoprotein. The Journal of Clinical Investigation. 98: 815-25. PMID 8698874 DOI: 10.1172/Jci118854 |
0.427 |
|
| 1996 |
Palinski W, Hörkkö S, Miller E, Steinbrecher UP, Powell HC, Curtiss LK, Witztum JL. Cloning of monoclonal autoantibodies to epitopes of oxidized lipoproteins from apolipoprotein E-deficient mice. Demonstration of epitopes of oxidized low density lipoprotein in human plasma. The Journal of Clinical Investigation. 98: 800-14. PMID 8698873 DOI: 10.1172/Jci118853 |
0.463 |
|
| 1995 |
Benz DJ, Mol M, Ezaki M, Mori-Ito N, Zelán I, Miyanohara A, Friedmann T, Parthasarathy S, Steinberg D, Witztum JL. Enhanced levels of lipoperoxides in low density lipoprotein incubated with murine fibroblast expressing high levels of human 15-lipoxygenase. The Journal of Biological Chemistry. 270: 5191-7. PMID 7890629 DOI: 10.1074/Jbc.270.10.5191 |
0.465 |
|
| 1995 |
Palinski W, Miller E, Witztum JL. Immunization of low density lipoprotein (LDL) receptor-deficient rabbits with homologous malondialdehyde-modified LDL reduces atherogenesis. Proceedings of the National Academy of Sciences of the United States of America. 92: 821-5. PMID 7846059 DOI: 10.1073/Pnas.92.3.821 |
0.417 |
|
| 1995 |
Palinski W, Koschinsky T, Butler SW, Miller E, Vlassara H, Cerami A, Witztum JL. Immunological evidence for the presence of advanced glycosylation end products in atherosclerotic lesions of euglycemic rabbits Arteriosclerosis, Thrombosis, and Vascular Biology. 15: 571-582. PMID 7749871 DOI: 10.1161/01.Atv.15.5.571 |
0.384 |
|
| 1995 |
Philis-Tsimikas A, Parthasarathy S, Picard S, Palinski W, Witztum JL. Aminoguanidine has both pro-oxidant and antioxidant activity toward LDL. Arteriosclerosis, Thrombosis, and Vascular Biology. 15: 367-76. PMID 7749847 DOI: 10.1161/01.Atv.15.3.367 |
0.423 |
|
| 1995 |
Stemme S, Faber B, Holm J, Wiklund O, Witztum JL, Hansson GK. T lymphocytes from human atherosclerotic plaques recognize oxidized low density lipoprotein Proceedings of the National Academy of Sciences of the United States of America. 92: 3893-3897. PMID 7732003 DOI: 10.1073/Pnas.92.9.3893 |
0.404 |
|
| 1995 |
Tangirala RK, Casanada F, Miller E, Witztum JL, Steinberg D, Palinski W. Effect of the antioxidant N,N'-diphenyl 1,4-phenylenediamine (DPPD) on atherosclerosis in apoE-deficient mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 15: 1625-30. PMID 7583536 DOI: 10.1161/01.Atv.15.10.1625 |
0.429 |
|
| 1995 |
Palinski W, Tangirala RK, Miller E, Young SG, Witztum JL. Increased autoantibody titers against epitopes of oxidized LDL in LDL receptor-deficient mice with increased atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology. 15: 1569-76. PMID 7583529 DOI: 10.1161/01.ATV.15.10.1569 |
0.334 |
|
| 1995 |
Ramprasad MP, Fischer W, Witztum JL, Sambrano GR, Quehenberger O, Steinberg D. The 94- to 97-kDa mouse macrophage membrane protein that recognizes oxidized low density lipoprotein and phosphatidylserine-rich liposomes is identical to macrosialin, the mouse homologue of human CD68 Proceedings of the National Academy of Sciences of the United States of America. 92: 9580-9584. PMID 7568176 DOI: 10.1073/Pnas.92.21.9580 |
0.344 |
|
| 1995 |
Reaven PD, Witztum JL. The Role of Oxidation of LDL in Atherogenesis The Endocrinologist. 5: 44-54. DOI: 10.1097/00019616-199501000-00007 |
0.42 |
|
| 1995 |
Mol M, Ezaki M, Witztum J, Steinberg D. Stimulation of human monocytes by interleukin-4 (IL-4) increases 15-lipoxygenase activity and inital rate of transfer of lipidhydroperoxides to LDL without an overall increase in extent of LDL oxidation Atherosclerosis. 115: S7. DOI: 10.1016/0021-9150(95)96279-2 |
0.341 |
|
| 1994 |
Witztum JL, Reaven PD, Parthasarathy S. Studies on the ability of dietary supplementation with beta-carotene to protect low-density lipoprotein from oxidative modification. Annals of the New York Academy of Sciences. 691: 200-6. PMID 8129290 DOI: 10.1111/J.1749-6632.1993.Tb26171.X |
0.37 |
|
| 1994 |
Witztum JL. The oxidation hypothesis of atherosclerosis. Lancet (London, England). 344: 793-5. PMID 7916078 DOI: 10.1016/S0140-6736(94)92346-9 |
0.383 |
|
| 1994 |
Palinski W, Ord VA, Plump AS, Breslow JL, Steinberg D, Witztum JL. ApoE-deficient mice are a model of lipoprotein oxidation in atherogenesis. Demonstration of oxidation-specific epitopes in lesions and high titers of autoantibodies to malondialdehyde-lysine in serum Arteriosclerosis, Thrombosis, and Vascular Biology. 14: 605-616. PMID 7511933 DOI: 10.1161/01.Atv.14.4.605 |
0.428 |
|
| 1994 |
Branch DW, Mitchell MD, Miller E, Palinski W, Witztum JL. Pre-eclampsia and serum antibodies to oxidised low-density lipoprotein The Lancet. 343: 645-646. PMID 7509433 DOI: 10.1016/S0140-6736(94)92639-5 |
0.414 |
|
| 1994 |
Yla-Herttuala S, Palinski W, Butler SW, Picard S, Steinberg D, Witztum JL. Rabbit and human atherosclerotic lesions contain IgG that recognizes epitopes of oxidized LDL Arteriosclerosis and Thrombosis. 14: 32-40. PMID 7506053 DOI: 10.1161/01.Atv.14.1.32 |
0.377 |
|
| 1994 |
Mol M, Benz D, Mori-Ito N, Ezaki M, Parthasarthy S, Steinberg D, Witztum J. 15-Lipoxygenase expression in fibroblasts confers an increased ability to oxidatively modify LDL Atherosclerosis. 109: 40-41. DOI: 10.1016/0021-9150(94)93175-5 |
0.394 |
|
| 1993 |
Witztum JL. Susceptibility of low-density lipoprotein to oxidative modification. The American Journal of Medicine. 94: 347-9. PMID 8475927 DOI: 10.1016/0002-9343(93)90143-D |
0.414 |
|
| 1993 |
Reaven PD, Witztum JL. Comparison of supplementation of RRR-alpha-tocopherol and racemic alpha-tocopherol in humans. Effects on lipid levels and lipoprotein susceptibility to oxidation. Arteriosclerosis and Thrombosis : a Journal of Vascular Biology. 13: 601-8. PMID 8466895 DOI: 10.1161/01.Atv.13.4.601 |
0.373 |
|
| 1993 |
Reaven PD, Khouw A, Beltz WF, Parthasarathy S, Witztum JL. Effect of dietary antioxidant combinations in humans. Protection of LDL by vitamin E but not by beta-carotene. Arteriosclerosis and Thrombosis : a Journal of Vascular Biology. 13: 590-600. PMID 8466894 DOI: 10.1161/01.Atv.13.4.590 |
0.339 |
|
| 1993 |
Reaven P, Parthasarathy S, Grasse BJ, Miller E, Steinberg D, Witztum JL. Effects of oleate-rich and linoleate-rich diets on the susceptibility of low density lipoprotein to oxidative modification in mildly hypercholesterolemic subjects Journal of Clinical Investigation. 91: 668-676. PMID 8432867 DOI: 10.1172/Jci116247 |
0.405 |
|
| 1993 |
Witztum JL. Role of oxidised low density lipoprotein in atherogenesis. British Heart Journal. 69: S12-8. PMID 8427759 DOI: 10.1136/Hrt.69.1_Suppl.S12 |
0.376 |
|
| 1993 |
Rosenfeld ME, Butler S, Ord VA, Lipton BA, Dyer CA, Curtiss LK, Palinski W, Witztum JL. Abundant expression of apoprotein E by macrophages in human and rabbit atherosclerotic lesions. Arteriosclerosis and Thrombosis : a Journal of Vascular Biology / American Heart Association. 13: 1382-9. PMID 8364022 DOI: 10.1161/01.Atv.13.9.1382 |
0.343 |
|
| 1992 |
Witztum JL, Steinberg D. Role of oxidized low density lipoprotein in atherogenesis. The Journal of Clinical Investigation. 88: 1785-92. PMID 1752940 DOI: 10.1172/Jci115499 |
0.452 |
|
| 1992 |
Parthasarathy S, Steinberg D, Witztum JL. The role of oxidized low-density lipoproteins in the pathogenesis of atherosclerosis. Annual Review of Medicine. 43: 219-25. PMID 1580586 DOI: 10.1146/Annurev.Me.43.020192.001251 |
0.374 |
|
| 1992 |
Reaven PD, Parthasarathy S, Beltz WF, Witztum JL. Effect of probucol dosage on plasma lipid and lipoprotein levels and on protection of low density lipoprotein against in vitro oxidation in humans. Arteriosclerosis and Thrombosis : a Journal of Vascular Biology. 12: 318-24. PMID 1547191 DOI: 10.1161/01.Atv.12.3.318 |
0.411 |
|
| 1992 |
Picard S, Parthasarathy S, Fruebis J, Witztum JL. Aminoguanidine inhibits oxidative modification of low density lipoprotein protein and the subsequent increase in uptake by macrophage scavenger receptors. Proceedings of the National Academy of Sciences of the United States of America. 89: 6876-80. PMID 1495978 DOI: 10.1073/Pnas.89.15.6876 |
0.439 |
|
| 1992 |
Khoo JC, Miller E, Pio F, Steinberg D, Witztum JL. Monoclonal antibodies against LDL further enhance macrophage uptake of LDL aggregates. Arteriosclerosis and Thrombosis : a Journal of Vascular Biology. 12: 1258-66. PMID 1420085 DOI: 10.1161/01.Atv.12.11.1258 |
0.415 |
|
| 1992 |
Salonen JT, Ylä-Herttuala S, Yamamoto R, Butler S, Korpela H, Salonen R, Nyyssönen K, Palinski W, Witztum JL. Autoantibody against oxidised LDL and progression of carotid atherosclerosis. Lancet (London, England). 339: 883-7. PMID 1348295 DOI: 10.1016/0140-6736(92)90926-T |
0.422 |
|
| 1991 |
Ylä-Herttuala S, Lipton BA, Rosenfeld ME, Särkioja T, Yoshimura T, Leonard EJ, Witztum JL, Steinberg D. Expression of monocyte chemoattractant protein 1 in macrophage-rich areas of human and rabbit atherosclerotic lesions. Proceedings of the National Academy of Sciences of the United States of America. 88: 5252-6. PMID 2052604 DOI: 10.1073/Pnas.88.12.5252 |
0.386 |
|
| 1991 |
Ylä-Herttuala S, Rosenfeld ME, Parthasarathy S, Sigal E, Särkioja T, Witztum JL, Steinberg D. Gene expression in macrophage-rich human atherosclerotic lesions. 15-lipoxygenase and acetyl low density lipoprotein receptor messenger RNA colocalize with oxidation specific lipid-protein adducts. The Journal of Clinical Investigation. 87: 1146-52. PMID 2010531 DOI: 10.1172/Jci115111 |
0.453 |
|
| 1991 |
Rosenfeld ME, Khoo JC, Miller E, Parthasarathy S, Palinski W, Witztum JL. Macrophage-derived foam cells freshly isolated from rabbit atherosclerotic lesions degrade modified lipoproteins, promote oxidation of low-density lipoproteins, and contain oxidation-specific lipid-protein adducts. The Journal of Clinical Investigation. 87: 90-9. PMID 1985115 DOI: 10.1172/Jci115006 |
0.477 |
|
| 1991 |
Reaven P, Parthasarathy S, Grasse BJ, Miller E, Almazan F, Mattson FH, Khoo JC, Steinberg D, Witztum JL. Feasibility of using an oleate-rich diet to reduce the susceptibility of low-density lipoprotein to oxidative modification in humans. The American Journal of Clinical Nutrition. 54: 701-6. PMID 1897476 DOI: 10.1093/Ajcn/54.4.701 |
0.444 |
|
| 1991 |
Witztum JL. The role of oxidized LDL in atherosclerosis. Advances in Experimental Medicine and Biology. 285: 353-65. PMID 1858567 DOI: 10.1007/978-1-4684-5904-3_43 |
0.413 |
|
| 1991 |
Ylä-Herttuala S, Lipton BA, Rosenfeld ME, Goldberg IJ, Steinberg D, Witztum JL. Macrophages and smooth muscle cells express lipoprotein lipase in human and rabbit atherosclerotic lesions. Proceedings of the National Academy of Sciences of the United States of America. 88: 10143-7. PMID 1719546 DOI: 10.1073/Pnas.88.22.10143 |
0.322 |
|
| 1990 |
Parthasarathy S, Khoo JC, Miller E, Barnett J, Witztum JL, Steinberg D. Low density lipoprotein rich in oleic acid is protected against oxidative modification: implications for dietary prevention of atherosclerosis. Proceedings of the National Academy of Sciences of the United States of America. 87: 3894-8. PMID 2339129 DOI: 10.1073/Pnas.87.10.3894 |
0.411 |
|
| 1990 |
Ylä-Herttuala S, Palinski W, Rosenfeld ME, Steinberg D, Witztum JL. Lipoproteins in normal and atherosclerotic aorta. European Heart Journal. 88-99. PMID 2226537 DOI: 10.1093/Eurheartj/11.Suppl_E.88 |
0.332 |
|
| 1990 |
Ylä-Herttuala S, Rosenfeld ME, Parthasarathy S, Glass CK, Sigal E, Witztum JL, Steinberg D. Colocalization of 15-lipoxygenase mRNA and protein with epitopes of oxidized low density lipoprotein in macrophage-rich areas of atherosclerotic lesions. Proceedings of the National Academy of Sciences of the United States of America. 87: 6959-63. PMID 1698286 DOI: 10.1073/Pnas.87.18.6959 |
0.458 |
|
| 1990 |
Rosenfeld ME, Palinski W, Ylä-Herttuala S, Butler S, Witztum JL. Distribution of oxidation specific lipid-protein adducts and apolipoprotein B in atherosclerotic lesions of varying severity from WHHL rabbits. Arteriosclerosis (Dallas, Tex.). 10: 336-49. PMID 1693069 DOI: 10.1161/01.Atv.10.3.336 |
0.444 |
|
| 1990 |
Palinski W, Ylä-Herttuala S, Rosenfeld ME, Butler SW, Socher SA, Parthasarathy S, Curtiss LK, Witztum JL. Antisera and monoclonal antibodies specific for epitopes generated during oxidative modification of low density lipoprotein. Arteriosclerosis (Dallas, Tex.). 10: 325-35. PMID 1693068 DOI: 10.1161/01.Atv.10.3.325 |
0.456 |
|
| 1989 |
Ylä-Herttuala S, Palinski W, Rosenfeld ME, Parthasarathy S, Carew TE, Butler S, Witztum JL, Steinberg D. Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man. The Journal of Clinical Investigation. 84: 1086-95. PMID 2794046 DOI: 10.1172/Jci114271 |
0.442 |
|
| 1989 |
Witztum JL. Current approaches to drug therapy for the hypercholesterolemic patient. Circulation. 80: 1101-14. PMID 2680156 DOI: 10.1161/01.Cir.80.5.1101 |
0.356 |
|
| 1989 |
Takiyyuddin MA, Cervenka JH, Dinh T, Witztum JL, O'Connor DT. Selective alpha-blockade versus angiotensin-converting enzyme inhibition as initial antihypertensive therapy. Effects on circulating lipoproteins. The American Journal of Medicine. 86: 32-5. PMID 2643863 DOI: 10.1016/0002-9343(89)90126-5 |
0.315 |
|
| 1989 |
Witztum JL, Simmons D, Steinberg D, Beltz WF, Weinreb R, Young SG, Lester P, Kelly N, Juliano J. Intensive combination drug therapy of familial hypercholesterolemia with lovastatin, probucol, and colestipol hydrochloride. Circulation. 79: 16-28. PMID 2642754 DOI: 10.1161/01.Cir.79.1.16 |
0.355 |
|
| 1989 |
Palinski W, Rosenfeld ME, Ylä-Herttuala S, Gurtner GC, Socher SS, Butler SW, Parthasarathy S, Carew TE, Steinberg D, Witztum JL. Low density lipoprotein undergoes oxidative modification in vivo. Proceedings of the National Academy of Sciences of the United States of America. 86: 1372-6. PMID 2465552 DOI: 10.1073/Pnas.86.4.1372 |
0.47 |
|
| 1988 |
Lopes-Virella MF, Klein RL, Lyons TJ, Stevenson HC, Witztum JL. Glycosylation of low-density lipoprotein enhances cholesteryl ester synthesis in human monocyte-derived macrophages. Diabetes. 37: 550-7. PMID 3129328 DOI: 10.2337/Diab.37.5.550 |
0.412 |
|
| 1988 |
Miyanohara A, Sharkey MF, Witztum JL, Steinberg D, Friedmann T. Efficient expression of retroviral vector-transduced human low density lipoprotein (LDL) receptor in LDL receptor-deficient rabbit fibroblasts in vitro. Proceedings of the National Academy of Sciences of the United States of America. 85: 6538-42. PMID 2842777 DOI: 10.1073/Pnas.85.17.6538 |
0.342 |
|
| 1987 |
Steinbrecher UP, Witztum JL, Parthasarathy S, Steinberg D. Decrease in reactive amino groups during oxidation or endothelial cell modification of LDL. Correlation with changes in receptor-mediated catabolism. Arteriosclerosis (Dallas, Tex.). 7: 135-43. PMID 3107534 DOI: 10.1161/01.Atv.7.2.135 |
0.358 |
|
| 1987 |
Curtiss LK, Steinbrecher UP, Witztum JL. Generation of region-specific antibodies to modified proteins Journal of Clinical Laboratory Analysis. 1: 266-271. DOI: 10.1002/Jcla.1860010304 |
0.315 |
|
| 1986 |
Parthasarathy S, Young SG, Witztum JL, Pittman RC, Steinberg D. Probucol inhibits oxidative modification of low density lipoprotein. The Journal of Clinical Investigation. 77: 641-4. PMID 3944273 DOI: 10.1172/Jci112349 |
0.351 |
|
| 1986 |
Levy RA, Ostlund RE, Semenkovich CF, Witztum JL. Diversity in expression of heterozygous familial hypercholesterolemia. Characterization of a unique kindred Journal of Clinical Investigation. 78: 96-101. PMID 3722389 DOI: 10.1172/Jci112579 |
0.406 |
|
| 1986 |
Young SG, Bertics SJ, Curtiss LK, Casal DC, Witztum JL. Monoclonal antibody MB19 detects genetic polymorphism in human apolipoprotein B. Proceedings of the National Academy of Sciences of the United States of America. 83: 1101-5. PMID 2419898 DOI: 10.1073/Pnas.83.4.1101 |
0.352 |
|
| 1985 |
Curtiss LK, Witztum JL. Plasma apolipoproteins AI, AII, B, CI, and E are glucosylated in hyperglycemic diabetic subjects. Diabetes. 34: 452-61. PMID 3921419 DOI: 10.2337/Diab.34.5.452 |
0.312 |
|
| 1985 |
Parthasarathy S, Steinbrecher UP, Barnett J, Witztum JL, Steinberg D. Essential role of phospholipase A2 activity in endothelial cell-induced modification of low density lipoprotein. Proceedings of the National Academy of Sciences of the United States of America. 82: 3000-4. PMID 3857630 DOI: 10.1073/Pnas.82.9.3000 |
0.41 |
|
| 1985 |
Hostetler KY, Pappu AS, Witztum JL. Diethylaminoethoxyhexestrol causes hypertriglyceridemia in guinea pigs Biochimica Et Biophysica Acta (Bba)/Lipids and Lipid Metabolism. 833: 165-169. PMID 2981562 DOI: 10.1016/0005-2760(85)90265-6 |
0.337 |
|
| 1984 |
Ehnholm C, Mahley RW, Chappell DA, Weisgraber KH, Ludwig E, Witztum JL. Role of apolipoprotein E in the lipolytic conversion of beta-very low density lipoproteins to low density lipoproteins in type III hyperlipoproteinemia. Proceedings of the National Academy of Sciences of the United States of America. 81: 5566-70. PMID 6591204 DOI: 10.1073/Pnas.81.17.5566 |
0.327 |
|
| 1984 |
Steinbrecher UP, Parthasarathy S, Leake DS, Witztum JL, Steinberg D. Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids. Proceedings of the National Academy of Sciences of the United States of America. 81: 3883-7. PMID 6587396 DOI: 10.1073/Pnas.81.12.3883 |
0.407 |
|
| 1984 |
Witztum JL, Steinbrecher UP, Kesaniemi YA, Fisher M. Autoantibodies to glucosylated proteins in the plasma of patients with diabetes mellitus. Proceedings of the National Academy of Sciences of the United States of America. 81: 3204-8. PMID 6587346 DOI: 10.1073/Pnas.81.10.3204 |
0.324 |
|
| 1984 |
Steinbrecher UP, Witztum JL. Glucosylation of low-density lipoproteins to an extent comparable to that seen in diabetes slows their catabolism. Diabetes. 33: 130-4. PMID 6420216 DOI: 10.2337/Diab.33.2.130 |
0.363 |
|
| 1983 |
Gordon DJ, Witztum JL, Hunninghake D, Gates S, Glueck CJ. Habitual physical activity and high-density lipoprotein cholesterol in men with primary hypercholesterolemia. The Lipid Research Clinics Coronary Primary Prevention Trial. Circulation. 67: 512-20. PMID 6821893 DOI: 10.1161/01.Cir.67.3.512 |
0.362 |
|
| 1983 |
Curtiss LK, Witztum JL. A novel method for generating region-specific monoclonal antibodies to modified proteins. Application to the identification of human glucosylated low density lipoproteins. The Journal of Clinical Investigation. 72: 1427-38. PMID 6415110 DOI: 10.1172/Jci111099 |
0.377 |
|
| 1983 |
Witztum JL, Steinbrecher UP, Fisher M, Kesaniemi A. Nonenzymatic glucosylation of homologous low density lipoprotein and albumin renders them immunogenic in the guinea pig. Proceedings of the National Academy of Sciences of the United States of America. 80: 2757-61. PMID 6405389 DOI: 10.1073/Pnas.80.9.2757 |
0.39 |
|
| 1983 |
Steinbrecher UP, Witztum JL, Kesaniemi YA, Elam RL. Comparison of glucosylated low density lipoprotein with methylated or cyclohexanedione-treated low density lipoprotein in the measurement of receptor-independent low density lipoprotein catabolism. The Journal of Clinical Investigation. 71: 960-4. PMID 6300195 DOI: 10.1172/Jci110850 |
0.387 |
|
| 1983 |
Kesaniemi YA, Witztum JL, Steinbrecher UP. Receptor-mediated catabolism of low density lipoprotein in man. Quantitation using glucosylated low density lipoprotein. The Journal of Clinical Investigation. 71: 950-9. PMID 6300194 DOI: 10.1172/Jci110849 |
0.382 |
|
| 1982 |
Witztum JL, Mahoney EM, Branks MJ, Fisher M, Elam R, Steinberg D. Nonenzymatic glucosylation of low-density lipoprotein alters its biologic activity. Diabetes. 31: 283-91. PMID 6818075 DOI: 10.2337/Diab.31.4.283 |
0.391 |
|
| 1982 |
Witztum JL, Fisher M, Pietro T, Steinbrecher UP, Elam RL. Nonenzymatic glucosylation of high-density lipoprotein accelerates its catabolism in guinea pigs. Diabetes. 31: 1029-32. PMID 6816643 DOI: 10.2337/Diacare.31.11.1029 |
0.357 |
|
| 1982 |
Ostlund RE, Levy RA, Witztum JL, Schonfeld G. Familial hypercholesterolemia. Evidence for a newly recognized mutation determining increased fibroblast receptor affinity but decreased capacity for low density lipoprotein in two siblings. The Journal of Clinical Investigation. 70: 823-31. PMID 6288770 DOI: 10.1172/Jci110678 |
0.35 |
|
| 1981 |
Ostlund RE, Hajek SV, Levy RA, Witztum JL. Analysis of lipids and endothelial and smooth muscle cells of umbilical cord in familial homozygous hypercholesterolemia. Metabolism: Clinical and Experimental. 30: 285-9. PMID 7207202 DOI: 10.1016/0026-0495(81)90153-0 |
0.352 |
|
| 1980 |
Witztum JL, Dillingham MA, Giese W, Bateman J, Diekman C, Blaufuss EK, Weidman S, Schonfeld G. Normalization on triglycerides in type IV hyperlipoproteinemia fails to correct low levels of high-density-lipoprotein cholesterol. The New England Journal of Medicine. 303: 907-14. PMID 7412822 DOI: 10.1056/Nejm198010163031603 |
0.381 |
|
| 1980 |
Patsch W, Witztum JL, Ostlund R, Schonfeld G. Structure, immunology, and cell reactivity of low density lipoprotein from umbilical vein of a newborn type II homozygote. The Journal of Clinical Investigation. 66: 123-9. PMID 7400306 DOI: 10.1172/Jci109825 |
0.413 |
|
| 1980 |
Falko JM, Schonfeld G, Witztum JL, Kolar JB, Salmon P. Effects of short-term high carbohydrate, fat-free diet on plasma levels of Apo C-II and Apo C-III and on the Apo C subspecies in human plasma lipoproteins. Metabolism: Clinical and Experimental. 29: 654-61. PMID 7382829 DOI: 10.1016/0026-0495(80)90110-9 |
0.338 |
|
| 1980 |
Falko JM, Schonfeld G, Witztum JL, Kolar JB, Weidman SW, Steelman R. Effects of diet on apoprotein E levels and on the apoprotein E subspecies in human plasma lipoproteins. The Journal of Clinical Endocrinology and Metabolism. 50: 521-8. PMID 7358833 DOI: 10.1210/Jcem-50-3-521 |
0.351 |
|
| 1980 |
Schonfeld G, Patsch W, Pfleger B, Witztum JL, Weidman SW. Lipolysis produces changes in the immunoreactivity and cell reactivity of very low density lipoproteins. The Journal of Clinical Investigation. 64: 1288-97. PMID 227930 DOI: 10.1172/Jci109584 |
0.386 |
|
| 1979 |
Schwarz KB, Witztum J, Schonfeld G, Grundy SM, Connor WE. Elevated cholesterol and bile acid synthesis in a young patient with homozygous familial hypercholesterolemia. The Journal of Clinical Investigation. 64: 756-60. PMID 468990 DOI: 10.1172/Jci109520 |
0.342 |
|
| 1979 |
Falko JM, Witztum JL, Schonfeld G, Bateman J. Dietary treatment of type V hyperlipoproteinemia fails to normalize low levels of high-density lipoprotein cholesterol. Annals of Internal Medicine. 91: 750-1. PMID 227301 DOI: 10.7326/0003-4819-91-5-750 |
0.361 |
|
| 1979 |
Falko JM, Schonfeld G, Witztum JL, Kolar J, Weidman SW. Effects of estrogen therapy on apolipoprotein E in type II hyperlipoproteinemia. Metabolism: Clinical and Experimental. 28: 1171-7. PMID 226834 DOI: 10.1016/0026-0495(79)90158-6 |
0.372 |
|
| 1979 |
Witztum JL, Schonfeld G. Lipoproteins in the plasma and hepatic perfusates of the Zucker fatty rat. Diabetes. 28: 509-16. PMID 220125 DOI: 10.2337/Diab.28.5.509 |
0.338 |
|
| 1979 |
Witztum J, Schonfeld G. High density lipoproteins. Diabetes. 28: 326-33. PMID 220124 DOI: 10.2337/Diab.28.4.326 |
0.336 |
|
| 1979 |
Falko JM, Witztum JL, Schonfeld G, Weidman SW, Kolar JB. Type III hyperlipoproteinemia: rise in high-density lipoprotein levels in response to therapy. The American Journal of Medicine. 66: 303-10. PMID 218451 DOI: 10.1016/0002-9343(79)90553-9 |
0.386 |
|
| 1979 |
Witztum JL, Schonfeld G, Weidman SW, Giese WE, Dillingham MA. Bile sequestrant therapy alters the compositions of low-density and high-density lipoproteins. Metabolism: Clinical and Experimental. 28: 221-9. PMID 216884 DOI: 10.1016/0026-0495(79)90067-2 |
0.379 |
|
| 1979 |
Witztum JL, Schonfeld G. Carbohydrate diet-induced changes in very low density lipoprotein composition and structure. Diabetes. 27: 1215-29. PMID 214369 DOI: 10.2337/Diab.27.12.1215 |
0.336 |
|
| 1976 |
Schonfeld G, Weidman SW, Witztum JL, Bowen RM. Alterations in levels and interrelations of plasma apolipoproteins induced by diet. Metabolism: Clinical and Experimental. 25: 261-75. PMID 175240 DOI: 10.1016/0026-0495(76)90084-6 |
0.364 |
|
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