Year |
Citation |
Score |
2023 |
Kwan EX, Alvino GM, Lynch KL, Levan PF, Amemiya HM, Wang XS, Johnson SA, Sanchez JC, Miller MA, Croy M, Lee SB, Naushab M, Bedalov A, Cuperus JT, Brewer BJ, et al. Ribosomal DNA replication time coordinates completion of genome replication and anaphase in yeast. Cell Reports. 42: 112161. PMID 36842087 DOI: 10.1016/j.celrep.2023.112161 |
0.676 |
|
2020 |
Chowdhury S, Sripathy S, Webster A, Park A, Lao U, Hsu JH, Loe T, Bedalov A, Simon JA. Discovery of Selective SIRT2 Inhibitors as Therapeutic Agents in B-Cell Lymphoma and Other Malignancies. Molecules (Basel, Switzerland). 25. PMID 31973227 DOI: 10.3390/Molecules25030455 |
0.317 |
|
2019 |
Dembitz V, Tomic B, Kodvanj I, Simon JA, Bedalov A, Visnjic D. The ribonucleoside AICAr induces differentiation of myeloid leukemia by activating the ATR/Chk1 kinase via pyrimidine depletion. The Journal of Biological Chemistry. PMID 31431503 DOI: 10.1074/Jbc.Ra119.009396 |
0.352 |
|
2019 |
Foss EJ, Gatbonton-Schwager T, Thiesen AH, Taylor E, Soriano R, Lao U, MacAlpine DM, Bedalov A. Sir2 suppresses transcription-mediated displacement of Mcm2-7 replicative helicases at the ribosomal DNA repeats. Plos Genetics. 15: e1008138. PMID 31083663 DOI: 10.1371/Journal.Pgen.1008138 |
0.361 |
|
2018 |
Foss EJ, Lao U, Bedalov A. G2-seq: A High Throughput Sequencing-based Technique for Identifying Late Replicating Regions of the Genome. Journal of Visualized Experiments : Jove. PMID 29630039 DOI: 10.3791/56286 |
0.382 |
|
2018 |
Leko V, Sripathy S, Adrianse RL, Loe T, Park A, Lao U, Foss EJ, Bartolomei MS, Bedalov A. Pooled shRNA Screen for Reactivation of MeCP2 on the Inactive X Chromosome. Journal of Visualized Experiments : Jove. PMID 29553562 DOI: 10.3791/56398 |
0.347 |
|
2017 |
Sripathy S, Leko V, Adrianse RL, Loe T, Foss EJ, Dalrymple E, Lao U, Gatbonton-Schwager T, Carter KT, Payer B, Paddison PJ, Grady WM, Lee JT, Bartolomei MS, Bedalov A. Screen for reactivation of MeCP2 on the inactive X chromosome identifies the BMP/TGF-β superfamily as a regulator of XIST expression. Proceedings of the National Academy of Sciences of the United States of America. PMID 28143937 DOI: 10.1073/Pnas.1621356114 |
0.34 |
|
2017 |
Foss EJ, Lao U, Dalrymple E, Adrianse RL, Loe T, Bedalov A. SIR2 suppresses replication gaps and genome instability by balancing replication between repetitive and unique sequences. Proceedings of the National Academy of Sciences of the United States of America. PMID 28049846 DOI: 10.1073/Pnas.1614781114 |
0.414 |
|
2016 |
Lessing D, Dial TO, Wei C, Payer B, Carrette LL, Kesner B, Szanto A, Jadhav A, Maloney DJ, Simeonov A, Theriault J, Hasaka T, Bedalov A, Bartolomei MS, Lee JT. A high-throughput small molecule screen identifies synergism between DNA methylation and Aurora kinase pathways for X reactivation. Proceedings of the National Academy of Sciences of the United States of America. 113: 14366-14371. PMID 28182563 DOI: 10.1073/Pnas.1617597113 |
0.336 |
|
2016 |
Bedalov A, Chowdhury S, Simon JA. Biology, Chemistry, and Pharmacology of Sirtuins. Methods in Enzymology. 574: 183-211. PMID 27423863 DOI: 10.1016/Bs.Mie.2016.03.011 |
0.391 |
|
2014 |
Mahajan SS, Scian M, Sripathy S, Posakony J, Lao U, Loe TK, Leko V, Thalhofer A, Schuler AD, Bedalov A, Simon JA. Development of pyrazolone and isoxazol-5-one cambinol analogues as sirtuin inhibitors. Journal of Medicinal Chemistry. 57: 3283-94. PMID 24697269 DOI: 10.1021/Jm4018064 |
0.347 |
|
2013 |
Tsuchiyama S, Kwan E, Dang W, Bedalov A, Kennedy BK. Sirtuins in yeast: phenotypes and tools. Methods in Molecular Biology (Clifton, N.J.). 1077: 11-37. PMID 24014397 DOI: 10.1007/978-1-62703-637-5_2 |
0.694 |
|
2013 |
Kwan EX, Foss EJ, Tsuchiyama S, Alvino GM, Kruglyak L, Kaeberlein M, Raghuraman MK, Brewer BJ, Kennedy BK, Bedalov A. A natural polymorphism in rDNA replication origins links origin activation with calorie restriction and lifespan. Plos Genetics. 9: e1003329. PMID 23505383 DOI: 10.1371/Journal.Pgen.1003329 |
0.702 |
|
2011 |
Burnett C, Valentini S, Cabreiro F, Goss M, Somogyvári M, Piper MD, Hoddinott M, Sutphin GL, Leko V, McElwee JJ, Vazquez-Manrique RP, Orfila AM, Ackerman D, Au C, Vinti G, ... ... Bedalov A, et al. Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila. Nature. 477: 482-5. PMID 21938067 DOI: 10.1038/Nature10296 |
0.373 |
|
2011 |
Foss EJ, Radulovic D, Shaffer SA, Goodlett DR, Kruglyak L, Bedalov A. Genetic variation shapes protein networks mainly through non-transcriptional mechanisms. Plos Biology. 9: e1001144. PMID 21909241 DOI: 10.1371/Journal.Pbio.1001144 |
0.364 |
|
2011 |
Kwan EX, Foss E, Kruglyak L, Bedalov A. Natural polymorphism in BUL2 links cellular amino acid availability with chronological aging and telomere maintenance in yeast. Plos Genetics. 7: e1002250. PMID 21901113 DOI: 10.1371/Journal.Pgen.1002250 |
0.687 |
|
2011 |
Marshall GM, Liu PY, Gherardi S, Scarlett CJ, Bedalov A, Xu N, Iraci N, Valli E, Ling D, Thomas W, van Bekkum M, Sekyere E, Jankowski K, Trahair T, Mackenzie KL, et al. SIRT1 promotes N-Myc oncogenesis through a positive feedback loop involving the effects of MKP3 and ERK on N-Myc protein stability. Plos Genetics. 7: e1002135. PMID 21698133 DOI: 10.1371/Journal.Pgen.1002135 |
0.301 |
|
2011 |
Marshall GM, Liu PY, Gherardi S, Scarlett CJ, Bedalov A, Xu N, Iraci N, MacKenzie KL, Haber M, Norris MD, Biankin AV, Perini G, Liu T. Abstract 3027: SIRT1 promotes N-Myc oncogenesis stabilizing N-Myc protein Cancer Research. 71: 3027-3027. DOI: 10.1158/1538-7445.Am2011-3027 |
0.301 |
|
2009 |
Newcomb B, Bedalov A. Identification of inhibitors of chromatin modifying enzymes using the yeast phenotypic screens. Methods in Molecular Biology (Clifton, N.J.). 548: 145-60. PMID 19521823 DOI: 10.1007/978-1-59745-540-4_8 |
0.349 |
|
2009 |
Van Gool F, Gallà M, Gueydan C, Kruys V, Prevot PP, Bedalov A, Mostoslavsky R, Alt FW, De Smedt T, Leo O. Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner. Nature Medicine. 15: 206-10. PMID 19151729 DOI: 10.1038/Nm.1906 |
0.315 |
|
2008 |
Arnoldo A, Curak J, Kittanakom S, Chevelev I, Lee VT, Sahebol-Amri M, Koscik B, Ljuma L, Roy PJ, Bedalov A, Giaever G, Nislow C, Merrill AR, Merrill RA, Lory S, et al. Identification of small molecule inhibitors of Pseudomonas aeruginosa exoenzyme S using a yeast phenotypic screen. Plos Genetics. 4: e1000005. PMID 18454192 DOI: 10.1371/Journal.Pgen.1000005 |
0.359 |
|
2007 |
Thaminy S, Newcomb B, Kim J, Gatbonton T, Foss E, Simon J, Bedalov A. Hst3 is regulated by Mec1-dependent proteolysis and controls the S phase checkpoint and sister chromatid cohesion by deacetylating histone H3 at lysine 56. The Journal of Biological Chemistry. 282: 37805-14. PMID 17977840 DOI: 10.1074/Jbc.M706384200 |
0.361 |
|
2007 |
Foss EJ, Radulovic D, Shaffer SA, Ruderfer DM, Bedalov A, Goodlett DR, Kruglyak L. Genetic basis of proteome variation in yeast. Nature Genetics. 39: 1369-75. PMID 17952072 DOI: 10.1038/Ng.2007.22 |
0.36 |
|
2006 |
Foss E, Bedalov A. Pharmacogenetics: yeast lead the way. Chemistry & Biology. 13: 236-8. PMID 16638528 DOI: 10.1016/J.Chembiol.2006.03.001 |
0.329 |
|
2006 |
Heltweg B, Gatbonton T, Schuler AD, Posakony J, Li H, Goehle S, Kollipara R, Depinho RA, Gu Y, Simon JA, Bedalov A. Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes. Cancer Research. 66: 4368-77. PMID 16618762 DOI: 10.1158/0008-5472.Can-05-3617 |
0.333 |
|
2006 |
Gatbonton T, Imbesi M, Nelson M, Akey JM, Ruderfer DM, Kruglyak L, Simon JA, Bedalov A. Telomere length as a quantitative trait: genome-wide survey and genetic mapping of telomere length-control genes in yeast. Plos Genetics. 2: e35. PMID 16552446 DOI: 10.1371/Journal.Pgen.0020035 |
0.424 |
|
2006 |
Gatbonton T, Imbesi M, Nelson M, Akey JM, Ruderfer DM, Kruglyak L, Simon JA, Bedalov A. Correction: Telomere Length as a Quantitative Trait: Genome-Wide Survey and Genetic Mapping of Telomere Length-Control Genes in Yeast Plos Genetics. 2: e104. DOI: 10.1371/Journal.Pgen.0020104 |
0.393 |
|
2005 |
Kaeberlein M, McDonagh T, Heltweg B, Hixon J, Westman EA, Caldwell SD, Napper A, Curtis R, DiStefano PS, Fields S, Bedalov A, Kennedy BK. Substrate-specific activation of sirtuins by resveratrol. The Journal of Biological Chemistry. 280: 17038-45. PMID 15684413 DOI: 10.1074/Jbc.M500655200 |
0.356 |
|
2004 |
Posakony J, Hirao M, Bedalov A. Identification and characterization of Sir2 inhibitors through phenotypic assays in yeast. Combinatorial Chemistry & High Throughput Screening. 7: 661-8. PMID 15578928 DOI: 10.2174/1386207043328346 |
0.411 |
|
2004 |
Bedalov A, Simon JA. Neuroscience. NAD to the rescue. Science (New York, N.Y.). 305: 954-5. PMID 15310883 DOI: 10.1126/Science.1102497 |
0.333 |
|
2004 |
Simon JA, Bedalov A. Yeast as a model system for anticancer drug discovery. Nature Reviews. Cancer. 4: 481-92. PMID 15170450 DOI: 10.1038/Nrc1372 |
0.354 |
|
2003 |
Hirao M, Posakony J, Nelson M, Hruby H, Jung M, Simon JA, Bedalov A. Identification of selective inhibitors of NAD+-dependent deacetylases using phenotypic screens in yeast. The Journal of Biological Chemistry. 278: 52773-82. PMID 14534292 DOI: 10.1074/Jbc.M308966200 |
0.363 |
|
2003 |
Bedalov A, Hirao M, Posakony J, Nelson M, Simon JA. NAD+-dependent deacetylase Hst1p controls biosynthesis and cellular NAD+ levels in Saccharomyces cerevisiae. Molecular and Cellular Biology. 23: 7044-54. PMID 12972620 DOI: 10.1128/Mcb.23.19.7044-7054.2003 |
0.353 |
|
2001 |
Bedalov A, Gatbonton T, Irvine WP, Gottschling DE, Simon JA. Identification of a small molecule inhibitor of Sir2p. Proceedings of the National Academy of Sciences of the United States of America. 98: 15113-8. PMID 11752457 DOI: 10.1073/Pnas.261574398 |
0.412 |
|
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