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Astra Dinculescu, Ph.D. - Publications

Affiliations: 
2002 University of Florida, Gainesville, Gainesville, FL, United States 
Area:
Molecular Biology
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38 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Xu L, Ruddick WN, Bolch SN, Klingeborn M, Dyka FM, Kulkarni MM, Simpson CP, Beltran WA, Rickman CB, Smith WC, Dinculescu A. Distinct phenotypic consequences of pathogenic C1QTNF5 mutants associated with late-onset retinal degeneration. The American Journal of Pathology. PMID 36328299 DOI: 10.1016/j.ajpath.2022.10.004  0.438
2022 Nelson TS, Simpson C, Dyka FM, Dinculescu A, Smith WC. A modified arrestin1 increases lactate production in the retina and slows retinal degeneration. Human Gene Therapy. PMID 35081746 DOI: 10.1089/hum.2021.272  0.455
2021 Dinculescu A, Link BA, Saperstein DA. Retinal Gene Therapy for Usher Syndrome: Current Developments, Challenges, and Perspectives. International Ophthalmology Clinics. 61: 109-124. PMID 34584048 DOI: 10.1097/IIO.0000000000000378  0.332
2019 Simpson CP, Bolch SN, Zhu P, Weidert F, Dinculescu A, Lobanova ES. Systemic Delivery of Genes to Retina Using Adeno-Associated Viruses. Advances in Experimental Medicine and Biology. 1185: 109-112. PMID 31884597 DOI: 10.1007/978-3-030-27378-1_18  0.52
2019 Xu L, Bolch SN, Santiago CP, Dyka FM, Akil O, Lobanova ES, Wang Y, Martemyanov KA, Hauswirth WW, Smith WC, Handa JT, Blackshaw S, Ash JD, Dinculescu A. Clarin-1 expression in adult mouse and human retina highlights a role of Müller glia in Usher syndrome. The Journal of Pathology. PMID 31625146 DOI: 10.1002/Path.5360  0.494
2018 Chekuri A, Sahu B, Chavali VRM, Voronchikhina M, Hermida AS, Suk JJ, Alapati AN, Bartsch DU, Ayala-Ramirez R, Zenteno JC, Dinculescu A, Jablonski MM, Borooah S, Ayyagari R. The long-term effects of gene therapy in a novel mouse model of human MFRP-associated retinopathy. Human Gene Therapy. PMID 30499344 DOI: 10.1089/Hum.2018.192  0.537
2018 Deng WT, Kolandaivelu S, Dinculescu A, Li J, Zhu P, Chiodo VA, Ramamurthy V, Hauswirth WW. Cone Phosphodiesterase-6γ' Subunit Augments Cone PDE6 Holoenzyme Assembly and Stability in a Mouse Model Lacking Both Rod and Cone PDE6 Catalytic Subunits. Frontiers in Molecular Neuroscience. 11: 233. PMID 30038560 DOI: 10.3389/Fnmol.2018.00233  0.486
2018 Dinculescu A, Dyka FM, Min SH, Stupay RM, Hooper MJ, Smith WC, Hauswirth WW. Co-Expression of Wild-Type and Mutant S163R C1QTNF5 in Retinal Pigment Epithelium. Advances in Experimental Medicine and Biology. 1074: 61-66. PMID 29721928 DOI: 10.1007/978-3-319-75402-4_8  0.496
2017 Geng R, Omar A, Gopal SR, Chen DH, Stepanyan R, Basch ML, Dinculescu A, Furness DN, Saperstein D, Hauswirth W, Lustig LR, Alagramam KN. Modeling and Preventing Progressive Hearing Loss in Usher Syndrome III. Scientific Reports. 7: 13480. PMID 29044151 DOI: 10.1038/S41598-017-13620-9  0.385
2017 Mowat FM, Occelli LM, Bartoe JT, Gervais KJ, Bruewer AR, Querubin J, Dinculescu A, Boye SL, Hauswirth WW, Petersen-Jones SM. Gene Therapy in a Large Animal Model of PDE6A-Retinitis Pigmentosa. Frontiers in Neuroscience. 11: 342. PMID 28676737 DOI: 10.3389/Fnins.2017.00342  0.587
2016 Dinculescu A, Stupay RM, Deng WT, Dyka FM, Min SH, Boye SL, Chiodo VA, Abrahan CE, Zhu P, Li Q, Strettoi E, Novelli E, Nagel-Wolfrum K, Wolfrum U, Smith WC, et al. AAV-Mediated Clarin-1 Expression in the Mouse Retina: Implications for USH3A Gene Therapy. Plos One. 11: e0148874. PMID 26881841 DOI: 10.1371/Journal.Pone.0148874  0.576
2015 Dinculescu A, Min SH, Dyka FM, Deng WT, Stupay RM, Chiodo V, Smith WC, Hauswirth WW. Pathological Effects of Mutant C1QTNF5 (S163R) Expression in Murine Retinal Pigment Epithelium. Investigative Ophthalmology & Visual Science. 56: 6971-80. PMID 26513502 DOI: 10.1167/Iovs.15-17166  0.524
2015 Deng WT, Dyka FM, Dinculescu A, Li J, Zhu P, Chiodo V, Boye SL, Conlon TJ, Erger KE, Cossette T, Hauswirth WW. Stability and Safety of an AAV Vector for Treating RPGR-ORF15 X-linked Retinitis Pigmentosa. Human Gene Therapy. PMID 26076799 DOI: 10.1089/hum.2015.035  0.368
2014 Dinculescu A, Min SH, Deng WT, Li Q, Hauswirth WW. Gene therapy in the rd6 mouse model of retinal degeneration. Advances in Experimental Medicine and Biology. 801: 711-8. PMID 24664762 DOI: 10.1007/978-1-4614-3209-8_89  0.601
2014 Mowat FM, Gornik KR, Dinculescu A, Boye SL, Hauswirth WW, Petersen-Jones SM, Bartoe JT. Tyrosine capsid-mutant AAV vectors for gene delivery to the canine retina from a subretinal or intravitreal approach. Gene Therapy. 21: 96-105. PMID 24225638 DOI: 10.1038/Gt.2013.64  0.566
2013 Han J, Dinculescu A, Dai X, Du W, Smith WC, Pang J. Review: the history and role of naturally occurring mouse models with Pde6b mutations. Molecular Vision. 19: 2579-89. PMID 24367157  0.471
2013 Deng WT, Sakurai K, Kolandaivelu S, Kolesnikov AV, Dinculescu A, Li J, Zhu P, Liu X, Pang J, Chiodo VA, Boye SL, Chang B, Ramamurthy V, Kefalov VJ, Hauswirth WW. Cone phosphodiesterase-6α' restores rod function and confers distinct physiological properties in the rod phosphodiesterase-6β-deficient rd10 mouse. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 11745-53. PMID 23864662 DOI: 10.1523/Jneurosci.1536-13.2013  0.512
2012 Deng WT, Dinculescu A, Li Q, Boye SL, Li J, Gorbatyuk MS, Pang J, Chiodo VA, Matthes MT, Yasumura D, Liu L, Alkuraya FS, Zhang K, Vollrath D, LaVail MM, et al. Tyrosine-mutant AAV8 delivery of human MERTK provides long-term retinal preservation in RCS rats. Investigative Ophthalmology & Visual Science. 53: 1895-904. PMID 22408006 DOI: 10.1167/Iovs.11-8831  0.572
2012 Pang JJ, Lei L, Dai X, Shi W, Liu X, Dinculescu A, McDowell JH. AAV-mediated gene therapy in mouse models of recessive retinal degeneration. Current Molecular Medicine. 12: 316-30. PMID 22300136 DOI: 10.2174/156652412799218877  0.565
2012 Dinculescu A, Estreicher J, Zenteno JC, Aleman TS, Schwartz SB, Huang WC, Roman AJ, Sumaroka A, Li Q, Deng WT, Min SH, Chiodo VA, Neeley A, Liu X, Shu X, et al. Gene therapy for retinitis pigmentosa caused by MFRP mutations: human phenotype and preliminary proof of concept. Human Gene Therapy. 23: 367-76. PMID 22142163 DOI: 10.1089/Hum.2011.169  0.581
2011 Ryals RC, Boye SL, Dinculescu A, Hauswirth WW, Boye SE. Quantifying transduction efficiencies of unmodified and tyrosine capsid mutant AAV vectors in vitro using two ocular cell lines. Molecular Vision. 17: 1090-102. PMID 21552473  0.38
2011 Pang JJ, Dai X, Boye SE, Barone I, Boye SL, Mao S, Everhart D, Dinculescu A, Liu L, Umino Y, Lei B, Chang B, Barlow R, Strettoi E, Hauswirth WW. Long-term retinal function and structure rescue using capsid mutant AAV8 vector in the rd10 mouse, a model of recessive retinitis pigmentosa. Molecular Therapy : the Journal of the American Society of Gene Therapy. 19: 234-42. PMID 21139570 DOI: 10.1038/Mt.2010.273  0.584
2011 Petrs-Silva H, Dinculescu A, Li Q, Deng WT, Pang JJ, Min SH, Chiodo V, Neeley AW, Govindasamy L, Bennett A, Agbandje-McKenna M, Zhong L, Li B, Jayandharan GR, Srivastava A, et al. Novel properties of tyrosine-mutant AAV2 vectors in the mouse retina. Molecular Therapy : the Journal of the American Society of Gene Therapy. 19: 293-301. PMID 21045809 DOI: 10.1038/Mt.2010.234  0.506
2011 Västinsalo H, Jalkanen R, Dinculescu A, Isosomppi J, Geller S, Flannery JG, Hauswirth WW, Sankila EM. Alternative splice variants of the USH3A gene Clarin 1 (CLRN1). European Journal of Human Genetics : Ejhg. 19: 30-5. PMID 20717163 DOI: 10.1038/Ejhg.2010.140  0.436
2009 Deng WT, Sakurai K, Liu J, Dinculescu A, Li J, Pang J, Min SH, Chiodo VA, Boye SL, Chang B, Kefalov VJ, Hauswirth WW. Functional interchangeability of rod and cone transducin alpha-subunits. Proceedings of the National Academy of Sciences of the United States of America. 106: 17681-6. PMID 19815523 DOI: 10.1073/Pnas.0901382106  0.477
2009 Tian G, Zhou Y, Hajkova D, Miyagi M, Dinculescu A, Hauswirth WW, Palczewski K, Geng R, Alagramam KN, Isosomppi J, Sankila EM, Flannery JG, Imanishi Y. Clarin-1, encoded by the Usher Syndrome III causative gene, forms a membranous microdomain: possible role of clarin-1 in organizing the actin cytoskeleton. The Journal of Biological Chemistry. 284: 18980-93. PMID 19423712 DOI: 10.1074/Jbc.M109.003160  0.344
2009 Petrs-Silva H, Dinculescu A, Li Q, Min SH, Chiodo V, Pang JJ, Zhong L, Zolotukhin S, Srivastava A, Lewin AS, Hauswirth WW. High-efficiency transduction of the mouse retina by tyrosine-mutant AAV serotype vectors. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 463-71. PMID 19066593 DOI: 10.1038/Mt.2008.269  0.525
2008 Li Q, Miller R, Han PY, Pang J, Dinculescu A, Chiodo V, Hauswirth WW. Intraocular route of AAV2 vector administration defines humoral immune response and therapeutic potential Molecular Vision. 14: 1760-1769. PMID 18836574  0.396
2008 Li Q, Dinculescu A, Shan Z, Miller R, Pang J, Lewin AS, Raizada MK, Hauswirth WW. Downregulation of p22phox in retinal pigment epithelial cells inhibits choroidal neovascularization in mice Molecular Therapy. 16: 1688-1694. PMID 18665154 DOI: 10.1038/Mt.2008.164  0.506
2008 Pang JJ, Boye SL, Kumar A, Dinculescu A, Deng W, Li J, Li Q, Rani A, Foster TC, Chang B, Hawes NL, Boatright JH, Hauswirth WW. AAV-mediated gene therapy for retinal degeneration in the rd10 mouse containing a recessive PDEbeta mutation. Investigative Ophthalmology & Visual Science. 49: 4278-83. PMID 18586879 DOI: 10.1167/Iovs.07-1622  0.469
2007 Aarnisalo AA, Pietola L, Joensuu J, Isosomppi J, Aarnisalo P, Dinculescu A, Lewin AS, Flannery J, Hauswirth WW, Sankila EM, Jero J. Anti-clarin-1 AAV-delivered ribozyme induced apoptosis in the mouse cochlea Hearing Research. 230: 9-16. PMID 17493778 DOI: 10.1016/J.Heares.2007.03.004  0.404
2006 Smith WC, Peterson JJ, Orisme W, Dinculescu A. Arrestin translocation in rod photoreceptors. Advances in Experimental Medicine and Biology. 572: 455-64. PMID 17249609 DOI: 10.1007/0-387-32442-9_63  0.34
2006 Molday LL, Min SH, Seeliger MW, Wu WW, Dinculescu A, Timmers AM, Janssen A, Tonagel F, Hudl K, Weber BH, Hauswirth WW, Molday RS. Disease mechanisms and gene therapy in a mouse model for X-linked retinoschisis. Advances in Experimental Medicine and Biology. 572: 283-9. PMID 17249585 DOI: 10.1007/0-387-32442-9_39  0.432
2006 Dinculescu A, Glushakova L, Min S, Hauswirth W. Adeno-associated virus-vectored gene therapy for retinal disease American Journal of Ophthalmology. 141: 238. DOI: 10.1016/j.ajo.2005.11.028  0.368
2005 Deng WT, Yan Z, Dinculescu A, Pang J, Teusner JT, Cortez NG, Berns KI, Hauswirth WW. Adeno-associated virus-mediated expression of vascular endothelial growth factor peptides inhibits retinal neovascularization in a mouse model of oxygen-induced retinopathy. Human Gene Therapy. 16: 1247-54. PMID 16259558 DOI: 10.1089/Hum.2005.16.1247  0.42
2005 Min SH, Molday LL, Seeliger MW, Dinculescu A, Timmers AM, Janssen A, Tonagel F, Tanimoto N, Weber BH, Molday RS, Hauswirth WW. Prolonged recovery of retinal structure/function after gene therapy in an Rs1h-deficient mouse model of x-linked juvenile retinoschisis. Molecular Therapy : the Journal of the American Society of Gene Therapy. 12: 644-51. PMID 16027044 DOI: 10.1016/J.Ymthe.2005.06.002  0.508
2005 Dinculescu A, Glushakova L, Min SH, Hauswirth WW. Adeno-associated virus-vectored gene therapy for retinal disease. Human Gene Therapy. 16: 649-63. PMID 15960597 DOI: 10.1016/J.Ajo.2005.11.028  0.581
2002 Dinculescu A, McDowell JH, Amici SA, Dugger DR, Richards N, Hargrave PA, Smith WC. Insertional mutagenesis and immunochemical analysis of visual arrestin interaction with rhodopsin. The Journal of Biological Chemistry. 277: 11703-8. PMID 11809770 DOI: 10.1074/Jbc.M111833200  0.528
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