Michael William Pennington, Ph.D. - Publications

Affiliations: 
Technical Operations AmbioPharm 
Area:
disulfide rich peptides, autoimmune diseases, Kv1.3 channel, ion channel blockers, venomics, peptide synthesis, proteolytic subbstrates and inhibitors
Website:
http://www.ambiopharm.com

57 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Pan Y, Zheng W, Sawyer RH, Pennington MW, Zheng X, Wang X, Wang M, Hu L, O'Connor J, Zhao T, Li Z, Schroeter ER, Wu F, Xu X, Zhou Z, et al. The molecular evolution of feathers with direct evidence from fossils. Proceedings of the National Academy of Sciences of the United States of America. PMID 30692253 DOI: 10.1073/pnas.1815703116  1
2019 Tanner MR, Pennington MW, Chauhan SS, Laragione T, Gulko PS, Beeton C. KCa1.1 and Kv1.3 channels regulate the interactions between fibroblast-like synoviocytes and T lymphocytes during rheumatoid arthritis. Arthritis Research & Therapy. 21: 6. PMID 30612588 DOI: 10.1186/s13075-018-1783-9  1
2018 Rangaraju S, Dammer EB, Raza SA, Rathakrishnan P, Xiao H, Gao T, Duong DM, Pennington MW, Lah JJ, Seyfried NT, Levey AI. Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer's disease. Molecular Neurodegeneration. 13: 24. PMID 29784049 DOI: 10.1186/s13024-018-0254-8  1
2018 Krishnarjuna B, Villegas-Moreno J, Mitchell ML, Csoti A, Peigneur S, Amero C, Pennington MW, Tytgat J, Panyi G, Norton RS. Synthesis, folding, structure and activity of a predicted peptide from the sea anemone Oulactis sp. with an ShKT fold. Toxicon : Official Journal of the International Society On Toxinology. PMID 29772211 DOI: 10.1016/j.toxicon.2018.05.006  1
2018 Tanner MR, Pennington MW, Chamberlain BH, Huq R, Gehrmann EJ, Laragione T, Gulko PS, Beeton C. Targeting KCa1.1 channels with a scorpion venom peptide for the therapy of rat models of rheumatoid arthritis. The Journal of Pharmacology and Experimental Therapeutics. PMID 29453198 DOI: 10.1124/jpet.117.245118  1
2018 Krishnarjuna B, MacRaild CA, Sunanda P, Morales RAV, Peigneur S, Macrander J, Yu HH, Daly M, Raghothama S, Dhawan V, Chauhan S, Tytgat J, Pennington MW, Norton RS. Corrigendum to "Structure, folding and stability of a minimal homologue from Anemonia sulcata of the sea anemone potassium channel blocker ShK" [Peptides 99 (2018) 169-178]. Peptides. PMID 29361315 DOI: 10.1016/j.peptides.2018.01.008  1
2017 Krishnarjuna B, MacRaild CA, Sunanda P, Morales RAV, Peigneur S, Macrander J, Yu HH, Daly M, Raghothama S, Dhawan V, Chauhan S, Tytgat J, Pennington MW, Norton RS. Structure, folding and stability of a minimal homologue from Anemonia sulcata of the sea anemone potassium channel blocker ShK. Peptides. PMID 28993277 DOI: 10.1016/j.peptides.2017.10.001  1
2017 Pennington MW, Czerwinski A, Norton RS. Peptide therapeutics from venom: Current status and potential. Bioorganic & Medicinal Chemistry. PMID 28988749 DOI: 10.1016/j.bmc.2017.09.029  1
2017 Rangaraju S, Raza SA, Pennati A, Deng Q, Dammer EB, Duong D, Pennington MW, Tansey MG, Lah JJ, Betarbet R, Seyfried NT, Levey AI. A systems pharmacology-based approach to identify novel Kv1.3 channel-dependent mechanisms in microglial activation. Journal of Neuroinflammation. 14: 128. PMID 28651603 DOI: 10.1186/s12974-017-0906-6  1
2017 Bergmann R, Kubeil M, Zarschler K, Chhabra S, Tajhya RB, Beeton C, Pennington MW, Bachmann M, Norton RS, Stephan H. Distribution and kinetics of the Kv1.3-blocking peptide HsTX1[R14A] in experimental rats. Scientific Reports. 7: 3756. PMID 28623364 DOI: 10.1038/s41598-017-03998-x  1
2017 Dang B, Chhabra S, Pennington MW, Norton RS, Kent SBH. Reinvestigation of the biological activity of D-allo-ShK protein. The Journal of Biological Chemistry. PMID 28596383 DOI: 10.1074/jbc.M117.793943  1
2017 Chittoor B, Bankala K, Morales RAW, MacRaild CA, Sadek M, Leung EW, Robinson S, Pennington M, Norton RS. The Single Disulfide-Directed β-Hairpin Fold. Dynamics, Stability and Engineering. Biochemistry. PMID 28437072 DOI: 10.1021/acs.biochem.7b00120  1
2017 Tanner MR, Pennington MW, Laragione T, Gulko PS, Beeton C. KCa1.1 channels regulate β1 integrin function and cell adhesion in rheumatoid arthritis fibroblast-like synoviocytes. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 28428266 DOI: 10.1096/fj.201601097R  1
2017 Tanner MR, Tajhya RB, Huq R, Gehrmann EJ, Rodarte KE, Atik MA, Norton RS, Pennington MW, Beeton C. Prolonged immunomodulation in inflammatory arthritis using the selective Kv1.3 channel blocker HsTX1[R14A] and its PEGylated analog. Clinical Immunology (Orlando, Fla.). PMID 28389388 DOI: 10.1016/j.clim.2017.03.014  1
2016 Jin L, Boyd BJ, Larson IC, Pennington MW, Norton RS, Nicolazzo JA. Enabling Noninvasive Systemic Delivery of the Kv1.3-Blocking Peptide HsTX1[R14A] via the Buccal Mucosa. Journal of Pharmaceutical Sciences. PMID 27312508 DOI: 10.1016/j.xphs.2016.05.008  1
2016 Jin L, Zhou QT, Chan HK, Larson IC, Pennington MW, Morales RA, Boyd BJ, Norton RS, Nicolazzo JA. Pulmonary Delivery of the Kv1.3-Blocking Peptide HsTX1[R14A] for the Treatment of Autoimmune Diseases. Journal of Pharmaceutical Sciences. 105: 650-6. PMID 26869426 DOI: 10.1016/j.xphs.2015.10.025  1
2015 Chang SC, Huq R, Chhabra S, Beeton C, Pennington MW, Smith BJ, Norton RS. N-terminally extended analogues of the K(+) channel toxin from Stichodactyla helianthus as potent and selective blockers of the voltage-gated potassium channel Kv1.3. The Febs Journal. 282: 2247-59. PMID 25864722 DOI: 10.1111/febs.13294  1
2015 Pennington MW, Chang SC, Chauhan S, Huq R, Tajhya RB, Chhabra S, Norton RS, Beeton C. Development of highly selective Kv1.3-blocking peptides based on the sea anemone peptide ShK. Marine Drugs. 13: 529-42. PMID 25603346 DOI: 10.3390/md13010529  1
2015 Jin L, Boyd BJ, White PJ, Pennington MW, Norton RS, Nicolazzo JA. Buccal mucosal delivery of a potent peptide leads to therapeutically-relevant plasma concentrations for the treatment of autoimmune diseases. Journal of Controlled Release : Official Journal of the Controlled Release Society. 199: 37-44. PMID 25482338 DOI: 10.1016/j.jconrel.2014.12.001  1
2014 Chhabra S, Chang SC, Nguyen HM, Huq R, Tanner MR, Londono LM, Estrada R, Dhawan V, Chauhan S, Upadhyay SK, Gindin M, Hotez PJ, Valenzuela JG, Mohanty B, Swarbrick JD, ... ... Pennington MW, et al. Kv1.3 channel-blocking immunomodulatory peptides from parasitic worms: implications for autoimmune diseases. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 3952-64. PMID 24891519 DOI: 10.1096/fj.14-251967  1
2014 Rashid MH, Huq R, Tanner MR, Chhabra S, Khoo KK, Estrada R, Dhawan V, Chauhan S, Pennington MW, Beeton C, Kuyucak S, Norton RS. A potent and Kv1.3-selective analogue of the scorpion toxin HsTX1 as a potential therapeutic for autoimmune diseases. Scientific Reports. 4: 4509. PMID 24676092 DOI: 10.1038/srep04509  1
2014 Koshy S, Huq R, Tanner MR, Atik MA, Porter PC, Khan FS, Pennington MW, Hanania NA, Corry DB, Beeton C. Blocking KV1.3 channels inhibits Th2 lymphocyte function and treats a rat model of asthma. The Journal of Biological Chemistry. 289: 12623-32. PMID 24644290 DOI: 10.1074/jbc.M113.517037  1
2014 Dekan Z, Mobli M, Pennington MW, Fung E, Nemeth E, Alewood PF. Total synthesis of human hepcidin through regioselective disulfide-bond formation by using the safety-catch cysteine protecting group 4,4'-dimethylsulfinylbenzhydryl. Angewandte Chemie (International Ed. in English). 53: 2931-4. PMID 24604812 DOI: 10.1002/anie.201310103  1
2013 Rashid MH, Heinzelmann G, Huq R, Tajhya RB, Chang SC, Chhabra S, Pennington MW, Beeton C, Norton RS, Kuyucak S. A potent and selective peptide blocker of the Kv1.3 channel: prediction from free-energy simulations and experimental confirmation. Plos One. 8: e78712. PMID 24244345 DOI: 10.1371/journal.pone.0078712  1
2013 Koshy S, Wu D, Hu X, Tajhya RB, Huq R, Khan FS, Pennington MW, Wulff H, Yotnda P, Beeton C. Blocking KCa3.1 channels increases tumor cell killing by a subpopulation of human natural killer lymphocytes. Plos One. 8: e76740. PMID 24146918 DOI: 10.1371/journal.pone.0076740  1
2012 Pennington MW, Harunur Rashid M, Tajhya RB, Beeton C, Kuyucak S, Norton RS. A C-terminally amidated analogue of ShK is a potent and selective blocker of the voltage-gated potassium channel Kv1.3. Febs Letters. 586: 3996-4001. PMID 23063513 DOI: 10.1016/j.febslet.2012.09.038  1
2012 Chang SC, Galea CA, Leung EW, Tajhya RB, Beeton C, Pennington MW, Norton RS. Expression and isotopic labelling of the potassium channel blocker ShK toxin as a thioredoxin fusion protein in bacteria. Toxicon : Official Journal of the International Society On Toxinology. 60: 840-50. PMID 22659540 DOI: 10.1016/j.toxicon.2012.05.017  1
2012 Tarcha EJ, Chi V, Muñoz-Elías EJ, Bailey D, Londono LM, Upadhyay SK, Norton K, Banks A, Tjong I, Nguyen H, Hu X, Ruppert GW, Boley SE, Slauter R, Sams J, ... ... Pennington MW, et al. Durable pharmacological responses from the peptide ShK-186, a specific Kv1.3 channel inhibitor that suppresses T cell mediators of autoimmune disease. The Journal of Pharmacology and Experimental Therapeutics. 342: 642-53. PMID 22637724 DOI: 10.1124/jpet.112.191890  1
2012 Chi V, Pennington MW, Norton RS, Tarcha EJ, Londono LM, Sims-Fahey B, Upadhyay SK, Lakey JT, Iadonato S, Wulff H, Beeton C, Chandy KG. Development of a sea anemone toxin as an immunomodulator for therapy of autoimmune diseases. Toxicon : Official Journal of the International Society On Toxinology. 59: 529-46. PMID 21867724 DOI: 10.1016/j.toxicon.2011.07.016  1
2011 Beeton C, Pennington MW, Norton RS. Analogs of the sea anemone potassium channel blocker ShK for the treatment of autoimmune diseases. Inflammation & Allergy Drug Targets. 10: 313-21. PMID 21824083  1
2010 Rangaraju S, Khoo KK, Feng ZP, Crossley G, Nugent D, Khaytin I, Chi V, Pham C, Calabresi P, Pennington MW, Norton RS, Chandy KG. Potassium channel modulation by a toxin domain in matrix metalloprotease 23. The Journal of Biological Chemistry. 285: 9124-36. PMID 19965868 DOI: 10.1074/jbc.M109.071266  1
2009 Rangaraju S, Chi V, Pennington MW, Chandy KG. Kv1.3 potassium channels as a therapeutic target in multiple sclerosis. Expert Opinion On Therapeutic Targets. 13: 909-24. PMID 19538097 DOI: 10.1517/14728220903018957  1
2009 Chauhan SS, Varshney A, Verma B, Pennington MW. Efficient synthesis of protected L-phosphonophenylalanine (Ppa) derivatives suitable for solid phase synthesis. Advances in Experimental Medicine and Biology. 611: 191-2. PMID 19400155 DOI: 10.1007/978-0-387-73657-0_88  1
2008 Matheu MP, Beeton C, Garcia A, Chi V, Rangaraju S, Safrina O, Monaghan K, Uemura MI, Li D, Pal S, de la Maza LM, Monuki E, Flügel A, Pennington MW, Parker I, et al. Imaging of effector memory T cells during a delayed-type hypersensitivity reaction and suppression by Kv1.3 channel block. Immunity. 29: 602-14. PMID 18835197 DOI: 10.1016/j.immuni.2008.07.015  1
2008 Beeton C, Smith BJ, Sabo JK, Crossley G, Nugent D, Khaytin I, Chi V, Chandy KG, Pennington MW, Norton RS. The D-diastereomer of ShK toxin selectively blocks voltage-gated K+ channels and inhibits T lymphocyte proliferation. The Journal of Biological Chemistry. 283: 988-97. PMID 17984097 DOI: 10.1074/jbc.M706008200  1
2007 Durr JA, Blankenship M, Chauhan SS, Pennington MW. Targeted tyrosine iodination in a multi-tyrosine vasopressin analog. Journal of Peptide Science : An Official Publication of the European Peptide Society. 13: 756-61. PMID 17803258 DOI: 10.1002/psc.890  1
2006 Beeton C, Wulff H, Standifer NE, Azam P, Mullen KM, Pennington MW, Kolski-Andreaco A, Wei E, Grino A, Counts DR, Wang PH, LeeHealey CJ, S Andrews B, Sankaranarayanan A, Homerick D, et al. Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases. Proceedings of the National Academy of Sciences of the United States of America. 103: 17414-9. PMID 17088564 DOI: 10.1073/pnas.0605136103  1
2006 Mullen KM, Rozycka M, Rus H, Hu L, Cudrici C, Zafranskaia E, Pennington MW, Johns DC, Judge SI, Calabresi PA. Potassium channels Kv1.3 and Kv1.5 are expressed on blood-derived dendritic cells in the central nervous system. Annals of Neurology. 60: 118-27. PMID 16729292 DOI: 10.1002/ana.20884  0.01
2005 Beeton C, Pennington MW, Wulff H, Singh S, Nugent D, Crossley G, Khaytin I, Calabresi PA, Chen CY, Gutman GA, Chandy KG. Targeting effector memory T cells with a selective peptide inhibitor of Kv1.3 channels for therapy of autoimmune diseases. Molecular Pharmacology. 67: 1369-81. PMID 15665253 DOI: 10.1124/mol.104.008193  1
2005 Lauth X, Babon JJ, Stannard JA, Singh S, Nizet V, Carlberg JM, Ostland VE, Pennington MW, Norton RS, Westerman ME. Bass hepcidin synthesis, solution structure, antimicrobial activities and synergism, and in vivo hepatic response to bacterial infections. The Journal of Biological Chemistry. 280: 9272-82. PMID 15546886 DOI: 10.1074/jbc.M411154200  1
2004 Norton RS, Pennington MW, Wulff H. Potassium channel blockade by the sea anemone toxin ShK for the treatment of multiple sclerosis and other autoimmune diseases. Current Medicinal Chemistry. 11: 3041-52. PMID 15578998  1
2004 Singh S, Rao SJ, Pennington MW. Efficient asymmetric synthesis of (S)- and (R)-N-Fmoc-S-trityl-alpha-methylcysteine using camphorsultam as a chiral auxiliary. The Journal of Organic Chemistry. 69: 4551-4. PMID 15202920 DOI: 10.1021/jo049622j  1
2004 Brady SF, Singh S, Crouthamel MC, Holloway MK, Coburn CA, Garsky VM, Bogusky M, Pennington MW, Vacca JP, Hazuda D, Lai MT. Rational design and synthesis of selective BACE-1 inhibitors. Bioorganic & Medicinal Chemistry Letters. 14: 601-4. PMID 14741251 DOI: 10.1016/j.bmcl.2003.11.061  1
2003 Kisselev AF, Garcia-Calvo M, Overkleeft HS, Peterson E, Pennington MW, Ploegh HL, Thornberry NA, Goldberg AL. The caspase-like sites of proteasomes, their substrate specificity, new inhibitors and substrates, and allosteric interactions with the trypsin-like sites. The Journal of Biological Chemistry. 278: 35869-77. PMID 12815064 DOI: 10.1074/jbc.M303725200  0.01
2002 Lanigan MD, Kalman K, Lefievre Y, Pennington MW, Chandy KG, Norton RS. Mutating a critical lysine in ShK toxin alters its binding configuration in the pore-vestibule region of the voltage-gated potassium channel, Kv1.3. Biochemistry. 41: 11963-71. PMID 12356296  1
1999 Pennington MW, Lanigan MD, Kalman K, Mahnir VM, Rauer H, McVaugh CT, Behm D, Donaldson D, Chandy KG, Kem WR, Norton RS. Role of disulfide bonds in the structure and potassium channel blocking activity of ShK toxin. Biochemistry. 38: 14549-58. PMID 10545177 DOI: 10.1021/bi991282m  1
1999 Dunn BM, Pennington MW, Frase DC, Nash K. Comparison of inhibitor binding to feline and human immunodeficiency virus proteases: structure-based drug design and the resistance problem. Biopolymers. 51: 69-77. PMID 10380354 DOI: 10.1002/(SICI)1097-0282(1999)51:1<69::AID-BIP8>3.0.CO;2-#  1
1998 Kalman K, Pennington MW, Lanigan MD, Nguyen A, Rauer H, Mahnir V, Paschetto K, Kem WR, Grissmer S, Gutman GA, Christian EP, Cahalan MD, Norton RS, Chandy KG. ShK-Dap22, a potent Kv1.3-specific immunosuppressive polypeptide. The Journal of Biological Chemistry. 273: 32697-707. PMID 9830012 DOI: 10.1074/jbc.273.49.32697  1
1996 Pennington MW, Mahnir VM, Khaytin I, Zaydenberg I, Byrnes ME, Kem WR. An essential binding surface for ShK toxin interaction with rat brain potassium channels. Biochemistry. 35: 16407-11. PMID 8987971 DOI: 10.1021/bi962463g  1
1996 Pennington MW, Mahnir VM, Krafte DS, Zaydenberg I, Byrnes ME, Khaytin I, Crowley K, Kem WR. Identification of three separate binding sites on SHK toxin, a potent inhibitor of voltage-dependent potassium channels in human T-lymphocytes and rat brain. Biochemical and Biophysical Research Communications. 219: 696-701. PMID 8645244 DOI: 10.1006/bbrc.1996.0297  1
1996 Dyke TR, Duggan BM, Pennington MW, Byrnes ME, Kem WR, Norton RS. Synthesis and structural characterisation of analogues of the potassium channel blocker charybdotoxin. Biochimica Et Biophysica Acta. 1292: 31-8. PMID 8547346 DOI: 10.1016/0167-4838(95)00182-4  1
1995 Holskin BP, Bukhtiyarova M, Dunn BM, Baur P, De Chastonay J, Pennington MW. A continuous fluorescence-based assay of human cytomegalovirus protease using a peptide substrate Analytical Biochemistry. 227: 148-155. PMID 7668375 DOI: 10.1006/abio.1995.1264  1
1994 Pennington MW, Zadenberg I, Byrnes ME, Norton RS, Kem WR. Synthesis of the cardiac inotropic polypeptide anthopleurin-A. International Journal of Peptide and Protein Research. 43: 463-70. PMID 8070970  1
1992 Pennington MW, Festin SM, Maccecchini ML, Kem WR. Synthesis and characterization of a disulfide bond isomer of omega-conotoxin GVIA. Toxicon : Official Journal of the International Society On Toxinology. 30: 755-64. PMID 1509493 DOI: 10.1016/0041-0101(92)90009-T  1
1990 Pennington MW, Kem WR, Dunn BM. Synthesis and biological activity of six monosubstituted analogs of a sea anemone polypeptide neurotoxin Peptide Research. 3: 228-232. PMID 2134066  1
1990 Pennington MW, Kem WR, Norton RS, Dunn BM. Chemical synthesis of a neurotoxic polypeptide from the sea anemone Stichodactyla helianthus International Journal of Peptide and Protein Research. 36: 335-343. PMID 1981881  1
1989 Kem WR, Parten B, Pennington MW, Price DA, Dunn BM. Isolation, characterization, and amino acid sequence of a polypeptide neurotoxin occurring in the sea anemone Stichodactyla helianthus Biochemistry. 28: 3483-3489. PMID 2568126  1
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