William R. Kem - Publications

Pharmacology University of Florida College of Medicine 

95 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Olincy A, Blakeley-Smith A, Johnson L, Kem WR, Freedman R. Brief Report: Initial Trial of Alpha7-Nicotinic Receptor Stimulation in Two Adult Patients with Autism Spectrum Disorder. Journal of Autism and Developmental Disorders. PMID 27565651 DOI: 10.1007/S10803-016-2890-6  0.76
2016 Green BT, Lee ST, Welch KD, Cook D, Kem WR. Activation and Desensitization of Peripheral Muscle and Neuronal Nicotinic Acetylcholine Receptors by Selected, Naturally-Occurring Pyridine Alkaloids. Toxins. 8. PMID 27384586 DOI: 10.3390/Toxins8070204  0.76
2015 Butala M, Šega D, Tomc B, Podlesek Z, Kem WR, Küpper FC, Turk T. Recombinant expression and predicted structure of parborlysin, a cytolytic protein from the Antarctic heteronemertine Parborlasia corrugatus. Toxicon : Official Journal of the International Society On Toxinology. 108: 32-7. PMID 26435341 DOI: 10.1016/J.Toxicon.2015.09.044  0.76
2015 Leong RL, Xing H, Braekman JC, Kem WR. Non-competitive Inhibition of Nicotinic Acetylcholine Receptors by Ladybird Beetle Alkaloids. Neurochemical Research. 40: 2078-86. PMID 25370792 DOI: 10.1007/s11064-014-1466-0  0.76
2013 Zovko A, Viktorsson K, Lewensohn R, Kološa K, Filipič M, Xing H, Kem WR, Paleari L, Turk T. APS8, a polymeric alkylpyridinium salt blocks α7 nAChR and induces apoptosis in non-small cell lung carcinoma. Marine Drugs. 11: 2574-94. PMID 23880932 DOI: 10.3390/Md11072574  0.76
2013 Isaacson MD, Horenstein NA, Stokes C, Kem WR, Papke RL. Point-to-point ligand-receptor interactions across the subunit interface modulate the induction and stabilization of conformational states of alpha7 nAChR by benzylidene anabaseines. Biochemical Pharmacology. 85: 817-28. PMID 23352650 DOI: 10.1016/J.Bcp.2013.01.010  0.76
2013 Suzuki S, Kawamata J, Matsushita T, Matsumura A, Hisahara S, Takata K, Kitamura Y, Kem W, Shimohama S. 3-[(2,4-Dimethoxy)benzylidene]-anabaseine dihydrochloride protects against 6-hydroxydopamine-induced parkinsonian neurodegeneration through α7 nicotinic acetylcholine receptor stimulation in rats. Journal of Neuroscience Research. 91: 462-71. PMID 23239187 DOI: 10.1002/Jnr.23160  0.76
2013 Kem WR. Worm Peptides Handbook of Biologically Active Peptides. 483-487. DOI: 10.1016/B978-0-12-385095-9.00065-8  0.76
2012 Rouchaud A, Kem WR. Racemic synthesis of 2′-substituted nicotine analogs Journal of Heterocyclic Chemistry. 49: 161-166. DOI: 10.1002/Jhet.841  0.76
2011 Kalappa BI, Feng L, Kem WR, Gusev AG, Uteshev VV. Mechanisms of facilitation of synaptic glutamate release by nicotinic agonists in the nucleus of the solitary tract. American Journal of Physiology. Cell Physiology. 301: C347-61. PMID 21613611 DOI: 10.1152/Ajpcell.00473.2010  0.76
2011 Tregellas JR, Tanabe J, Rojas DC, Shatti S, Olincy A, Johnson L, Martin LF, Soti F, Kem WR, Leonard S, Freedman R. Effects of an alpha 7-nicotinic agonist on default network activity in schizophrenia. Biological Psychiatry. 69: 7-11. PMID 20728875 DOI: 10.1016/J.Biopsych.2010.07.004  0.76
2010 Shen H, Kihara T, Hongo H, Wu X, Kem WR, Shimohama S, Akaike A, Niidome T, Sugimoto H. Neuroprotection by donepezil against glutamate excitotoxicity involves stimulation of alpha7 nicotinic receptors and internalization of NMDA receptors. British Journal of Pharmacology. 161: 127-39. PMID 20718745 DOI: 10.1111/J.1476-5381.2010.00894.X  0.76
2010 Stevens KE, Cornejo B, Adams CE, Zheng L, Yonchek J, Hoffman KL, Christians U, Kem WR. Continuous administration of a selective alpha7 nicotinic partial agonist, DMXBA, improves sensory inhibition without causing tachyphylaxis or receptor upregulation in DBA/2 mice. Brain Research. 1352: 140-6. PMID 20599427 DOI: 10.1016/J.Brainres.2010.06.063  0.76
2010 Razpotnik A, Krizaj I, Sribar J, Kordis D, Macek P, Frangez R, Kem WR, Turk T. A new phospholipase A2 isolated from the sea anemone Urticina crassicornis - its primary structure and phylogenetic classification. The Febs Journal. 277: 2641-53. PMID 20553498 DOI: 10.1111/J.1742-464X.2010.07674.X  0.76
2010 Slavov SH, Radzvilovits M, LeFrancois S, Stoyanova-Slavova IB, Soti F, Kem WR, Katritzky AR. A computational study of the binding of 3-(arylidene) anabaseines to two major brain nicotinic acetylcholine receptors and to the acetylcholine binding protein. European Journal of Medicinal Chemistry. 45: 2433-46. PMID 20236734 DOI: 10.1016/J.Ejmech.2010.02.027  0.76
2010 Green BT, Lee ST, Panter KE, Welch KD, Cook D, Pfister JA, Kem WR. Actions of piperidine alkaloid teratogens at fetal nicotinic acetylcholine receptors. Neurotoxicology and Teratology. 32: 383-90. PMID 20116429 DOI: 10.1016/J.Ntt.2010.01.011  0.76
2010 Tregellas JR, Olincy A, Johnson L, Tanabe J, Shatti S, Martin LF, Singel D, Du YP, Soti F, Kem WR, Freedman R. Functional magnetic resonance imaging of effects of a nicotinic agonist in schizophrenia. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 35: 938-42. PMID 19956085 DOI: 10.1038/Npp.2009.196  0.76
2010 Rouchaud A, Kem WR. A convenient racemic synthesis of two isomeric tetrahydropyridyl alkaloids: Isoanatabine and anatabine Journal of Heterocyclic Chemistry. 47: 569-581. DOI: 10.1002/Jhet.359  0.76
2009 López-Hernández GY, Thinschmidt JS, Morain P, Trocme-Thibierge C, Kem WR, Soti F, Papke RL. Positive modulation of alpha7 nAChR responses in rat hippocampal interneurons to full agonists and the alpha7-selective partial agonists, 4OH-GTS-21 and S 24795. Neuropharmacology. 56: 821-30. PMID 19705574 DOI: 10.1016/J.Neuropharm.2009.01.011  0.76
2009 Hibbs RE, Sulzenbacher G, Shi J, Talley TT, Conrod S, Kem WR, Taylor P, Marchot P, Bourne Y. Structural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal alpha7 nicotinic acetylcholine receptor. The Embo Journal. 28: 3040-51. PMID 19696737 DOI: 10.1038/Emboj.2009.227  0.76
2009 Turk T, Kem WR. The phylum Cnidaria and investigations of its toxins and venoms until 1990 Toxicon. 54: 1031-1037. PMID 19576920 DOI: 10.1016/J.Toxicon.2009.06.031  0.76
2009 Razpotnik A, Križaj I, Kem WR, Maček P, Turk T. A new cytolytic protein from the sea anemone Urticina crassicornis that binds to cholesterol- and sphingomyelin-rich membranes Toxicon. 53: 762-769. PMID 19232528 DOI: 10.1016/J.Toxicon.2009.02.007  0.76
2009 Papke RL, Kem WR, Soti F, López-Hernández GY, Horenstein NA. Activation and desensitization of nicotinic alpha7-type acetylcholine receptors by benzylidene anabaseines and nicotine. The Journal of Pharmacology and Experimental Therapeutics. 329: 791-807. PMID 19223664 DOI: 10.1124/Jpet.108.150151  0.76
2009 Kem WR, Rocca J, Garraffo HM, Spande TF, Daly JW, Soti F. Synthesis and spectroscopic comparison of the eight methyl-2,3′-bipyridyls and identification of a hoplonemertine alkaloid as 3-methyl-2,3′-bipyridyl Heterocycles. 79: 1025-1041. DOI: 10.3987/Com-08-S(D)80  0.76
2009 Kem WR, Turk T. Preface Toxicon. 54: 1029. DOI: 10.1016/j.toxicon.2009.06.029  0.76
2008 Rowland NE, Robertson K, Soti F, Kem WR. Nicotine analog inhibition of nicotine self-administration in rats. Psychopharmacology. 199: 605-13. PMID 18536909 DOI: 10.1007/S00213-008-1186-8  0.76
2008 Freedman R, Olincy A, Buchanan RW, Harris JG, Gold JM, Johnson L, Allensworth D, Guzman-Bonilla A, Clement B, Ball MP, Kutnick J, Pender V, Martin LF, Stevens KE, Wagner BD, ... ... Kem WR, et al. Initial phase 2 trial of a nicotinic agonist in schizophrenia. The American Journal of Psychiatry. 165: 1040-7. PMID 18381905 DOI: 10.1176/Appi.Ajp.2008.07071135  0.76
2006 Talley TT, Yalda S, Ho KY, Tor Y, Soti FS, Kem WR, Taylor P. Spectroscopic analysis of benzylidene anabaseine complexes with acetylcholine binding proteins as models for ligand-nicotinic receptor interactions. Biochemistry. 45: 8894-902. PMID 16846232 DOI: 10.1021/Bi060534Y  0.76
2006 Olincy A, Harris JG, Johnson LL, Pender V, Kongs S, Allensworth D, Ellis J, Zerbe GO, Leonard S, Stevens KE, Stevens JO, Martin L, Adler LE, Soti F, Kem WR, et al. Proof-of-concept trial of an alpha7 nicotinic agonist in schizophrenia. Archives of General Psychiatry. 63: 630-8. PMID 16754836 DOI: 10.1001/Archpsyc.63.6.630  0.76
2006 Zhang R, White NA, Soti FS, Kem WR, Machu TK. N-terminal domains in mouse and human 5-hydroxytryptamine3A receptors confer partial agonist and antagonist properties to benzylidene analogs of anabaseine. The Journal of Pharmacology and Experimental Therapeutics. 317: 1276-84. PMID 16551836 DOI: 10.1124/Jpet.106.101485  0.76
2006 Lee ST, Wildeboer K, Panter KE, Kem WR, Gardner DR, Molyneux RJ, Chang CW, Soti F, Pfister JA. Relative toxicities and neuromuscular nicotinic receptor agonistic potencies of anabasine enantiomers and anabaseine. Neurotoxicology and Teratology. 28: 220-8. PMID 16488116 DOI: 10.1016/J.Ntt.2005.12.010  0.76
2006 Kem W, Soti F, Wildeboer K, LeFrancois S, MacDougall K, Wei DQ, Chou KC, Arias HR. The nemertine toxin anabaseine and its derivative DMXBA (GTS-21): Chemical and pharmacological properties Marine Drugs. 4: 255-273. DOI: 10.3390/Md403255  0.76
2006 Kem WR. Worm Venom Peptides Handbook of Biologically Active Peptides. 397-401. DOI: 10.1016/B978-012369442-3/50060-X  0.76
2004 Kem WR, Wildeboer K, LeFrancois S, Raja M, Marszalec W, Braekman JC. Nicotinic receptor inhibition by Tetraponera ant alkaloids. Cellular and Molecular Neurobiology. 24: 535-51. PMID 15233377 DOI: 10.1023/B:Cemn.0000023628.65936.A7  0.76
2004 Stokes C, Papke JK, Horenstein NA, Kem WR, McCormack TJ, Papke RL. The structural basis for GTS-21 selectivity between human and rat nicotinic alpha7 receptors. Molecular Pharmacology. 66: 14-24. PMID 15213292 DOI: 10.1124/Mol.66.1.14  0.76
2004 Martin LF, Kem WR, Freedman R. Alpha-7 nicotinic receptor agonists: Potential new candidates for the treatment of schizophrenia Psychopharmacology. 174: 54-64. PMID 15205879 DOI: 10.1007/S00213-003-1750-1  0.76
2004 Kem WR, Mahnir VM, Prokai L, Papke RL, Cao X, LeFrancois S, Wildeboer K, Prokai-Tatrai K, Porter-Papke J, Soti F. Hydroxy metabolites of the Alzheimer's drug candidate 3-[(2,4-dimethoxy)benzylidene]-anabaseine dihydrochloride (GTS-21): their molecular properties, interactions with brain nicotinic receptors, and brain penetration. Molecular Pharmacology. 65: 56-67. PMID 14722237 DOI: 10.1124/Mol.65.1.56  0.76
2003 Kem WR, Soti F, Rittschof D. Inhibition of barnacle larval settlement and crustacean toxicity of some hoplonemertine pyridyl alkaloids. Biomolecular Engineering. 20: 355-61. PMID 12919820 DOI: 10.1016/S1389-0344(03)00049-2  0.76
2003 O'Neill HC, Rieger K, Kem WR, Stevens KE. DMXB, an alpha7 nicotinic agonist, normalizes auditory gating in isolation-reared rats. Psychopharmacology. 169: 332-9. PMID 12759805 DOI: 10.1007/S00213-003-1482-2  0.76
2003 Berne S, Sepcić K, Krizaj I, Kem WR, McClintock JB, Turk T. Isolation and characterisation of a cytolytic protein from mucus secretions of the Antarctic heteronemertine Parborlasia corrugatus. Toxicon : Official Journal of the International Society On Toxinology. 41: 483-91. PMID 12657318 DOI: 10.1016/S0041-0101(02)00386-0  0.76
2003 Arias HR, Kem WR, Trudell JR, Blanton MP. Unique general anesthetic binding sites within distinct conformational states of the nicotinic acetylcholine receptor International Review of Neurobiology. 54: 1-50. DOI: 10.1016/S0074-7742(03)54002-8  0.76
2002 Stevens SM, Kem WR, Prokai L. Investigation of cytolysin variants by peptide mapping: enhanced protein characterization using complementary ionization and mass spectrometric techniques. Rapid Communications in Mass Spectrometry : Rcm. 16: 2094-101. PMID 12415542 DOI: 10.1002/Rcm.837  0.76
2001 Simosky JK, Stevens KE, Kem WR, Freedman R. Intragastric DMXB-A, an alpha7 nicotinic agonist, improves deficient sensory inhibition in DBA/2 mice. Biological Psychiatry. 50: 493-500. PMID 11600102 DOI: 10.1016/S0006-3223(01)01093-9  0.76
2001 Kem WR, Soti F. Amphiporus alkaloid multiplicity implies functional diversity: Initial studies on crustacean pyridyl receptors Hydrobiologia. 456: 221-231. DOI: 10.1023/A:1013063726807  0.76
2000 Adams CE, Stevens KE, Kem WR, Freedman R. Inhibition of nitric oxide synthase prevents alpha 7 nicotinic receptor-mediated restoration of inhibitory auditory gating in rat hippocampus. Brain Research. 877: 235-44. PMID 10986337 DOI: 10.1016/S0006-8993(00)02677-9  0.76
2000 Kem WR. The brain alpha7 nicotinic receptor may be an important therapeutic target for the treatment of Alzheimer's disease: studies with DMXBA (GTS-21). Behavioural Brain Research. 113: 169-81. PMID 10942043 DOI: 10.1016/S0166-4328(00)00211-4  0.76
1999 Stevens KE, Kem WR, Freedman R. Selective alpha 7 nicotinic receptor stimulation normalizes chronic cocaine-induced loss of hippocampal sensory inhibition in C3H mice. Biological Psychiatry. 46: 1443-50. PMID 10578459 DOI: 10.1016/S0006-3223(99)00200-0  0.76
1999 Pennington MW, Lanigan MD, Kalman K, Mahnir VM, Rauer H, McVaugh CT, Behm D, Donaldson D, Chandy KG, Kem WR, Norton RS. Role of disulfide bonds in the structure and potassium channel blocking activity of ShK toxin. Biochemistry. 38: 14549-58. PMID 10545177 DOI: 10.1021/Bi991282M  0.76
1999 van Haaren F, Anderson KG, Haworth SC, Kem WR. GTS-21, a mixed nicotinic receptor agonist/antagonist, does not affect the nicotine cue. Pharmacology, Biochemistry, and Behavior. 64: 439-44. PMID 10515327 DOI: 10.1016/S0091-3057(99)00054-4  0.76
1999 Kem WR, Pennington MW, Norton RS. Sea anemone toxins as templates for the design of immunosuppressant drugs Perspectives in Drug Discovery and Design. 15: 111-129. DOI: 10.1023/A:1017071131670  0.76
1998 Kalman K, Pennington MW, Lanigan MD, Nguyen A, Rauer H, Mahnir V, Paschetto K, Kem WR, Grissmer S, Gutman GA, Christian EP, Cahalan MD, Norton RS, Chandy KG. ShK-Dap22, a potent Kv1.3-specific immunosuppressive polypeptide. The Journal of Biological Chemistry. 273: 32697-707. PMID 9830012 DOI: 10.1074/Jbc.273.49.32697  0.76
1998 Stevens KE, Kem WR, Mahnir VM, Freedman R. Selective alpha7-nicotinic agonists normalize inhibition of auditory response in DBA mice. Psychopharmacology. 136: 320-7. PMID 9600576 DOI: 10.1007/S002130050573  0.76
1998 Mahnir V, Lin B, Prokai-Tatrai K, Kem WR. Pharmacokinetics and urinary excretion of DMXBA (GTS-21), a compound enhancing cognition. Biopharmaceutics & Drug Disposition. 19: 147-51. PMID 9569996 DOI: 10.1002/(Sici)1099-081X(199804)19:3<147::Aid-Bdd77>3.0.Co;2-9  0.76
1997 Kem WR. Alzheimer's drug design based upon an invertebrate toxin (anabaseine) which is a potent nicotinic receptor agonist. Invertebrate Neuroscience : In. 3: 251-9. PMID 9783447 DOI: 10.1007/Bf02480382  0.76
1997 Summers KL, Kem WR, Giacobini E. Nicotinic agonist modulation of neurotransmitter levels in the rat frontoparietal cortex. Japanese Journal of Pharmacology. 74: 139-46. PMID 9243321 DOI: 10.1254/Jjp.74.139  0.76
1997 Barnham KJ, Dyke TR, Kem WR, Norton RS. Structure of neurotoxin B-IV from the marine worm Cerebratulus lacteus: a helical hairpin cross-linked by disulphide bonding. Journal of Molecular Biology. 268: 886-902. PMID 9180379 DOI: 10.1006/Jmbi.1997.0980  0.76
1996 Pennington MW, Mahnir VM, Khaytin I, Zaydenberg I, Byrnes ME, Kem WR. An essential binding surface for ShK toxin interaction with rat brain potassium channels. Biochemistry. 35: 16407-11. PMID 8987971 DOI: 10.1021/bi962463g  0.44
1996 Pennington MW, Mahnir VM, Krafte DS, Zaydenberg I, Byrnes ME, Khaytin I, Crowley K, Kem WR. Identification of three separate binding sites on SHK toxin, a potent inhibitor of voltage-dependent potassium channels in human T-lymphocytes and rat brain. Biochemical and Biophysical Research Communications. 219: 696-701. PMID 8645244 DOI: 10.1006/Bbrc.1996.0297  0.76
1996 Dyke TR, Duggan BM, Pennington MW, Byrnes ME, Kem WR, Norton RS. Synthesis and structural characterisation of analogues of the potassium channel blocker charybdotoxin. Biochimica Et Biophysica Acta. 1292: 31-8. PMID 8547346 DOI: 10.1016/0167-4838(95)00182-4  0.76
1996 Bjugstad KB, Mahnir VM, Kem WR, Socci DJ, Arendash GW. Long-term treatment with GTS-21 or nicotine enhances water maze performance in aged rats without affecting the density of nicotinic receptor subtypes in neocortex Drug Development Research. 39: 19-28. DOI: 10.1002/(Sici)1098-2299(19960901)39:1<19::Aid-Ddr3>3.0.Co;2-N  0.76
1995 Pennington MW, Byrnes ME, Zaydenberg I, Khaytin I, de Chastonay J, Krafte DS, Hill R, Mahnir VM, Volberg WA, Gorczyca W. Chemical synthesis and characterization of ShK toxin: a potent potassium channel inhibitor from a sea anemone. International Journal of Peptide and Protein Research. 46: 354-8. PMID 8567178 DOI: 10.1111/J.1399-3011.1995.Tb01068.X  0.76
1995 Arendash GW, Sengstock GJ, Sanberg PR, Kem WR. Improved learning and memory in aged rats with chronic administration of the nicotinic receptor agonist GTS-21. Brain Research. 674: 252-9. PMID 7796104 DOI: 10.1016/0006-8993(94)01449-R  0.76
1994 Kem WR. Structure and membrane actions of a marine worm protein cytolysin, Cerebratulus toxin A-III. Toxicology. 87: 189-203. PMID 8160185 DOI: 10.1016/0300-483X(94)90251-8  0.76
1994 Pennington MW, Zadenberg I, Byrnes ME, Norton RS, Kem WR. Synthesis of the cardiac inotropic polypeptide anthopleurin-A. International Journal of Peptide and Protein Research. 43: 463-70. PMID 8070970 DOI: 10.1111/J.1399-3011.1994.Tb00545.X  0.76
1994 Woodruff-Pak DS, Li YT, Kem WR. A nicotinic agonist (GTS-21), eyeblink classical conditioning, and nicotinic receptor binding in rabbit brain. Brain Research. 645: 309-17. PMID 8062092 DOI: 10.1016/0006-8993(94)91665-9  0.76
1994 Hunter BE, de Fiebre CM, Papke RL, Kem WR, Meyer EM. A novel nicotinic agonist facilitates induction of long-term potentiation in the rat hippocampus. Neuroscience Letters. 168: 130-4. PMID 8028765 DOI: 10.1016/0304-3940(94)90433-2  0.76
1994 Woodruff-Pak DS, Li YT, Kazmi A, Kem WR. Nicotinic cholinergic system involvement in eyeblink classical conditioning in rabbits. Behavioral Neuroscience. 108: 486-93. PMID 7917042 DOI: 10.1037//0735-7044.108.3.486  0.76
1994 Monks SA, Gould AR, Lumley PE, Alewood PF, Kem WR, Goss NH, Norton RS. Limited proteolysis study of structure-function relationships in Sh I, a polypeptide neurotoxin from a sea anemone. Biochimica Et Biophysica Acta. 1207: 93-101. PMID 7913833 DOI: 10.1016/0167-4838(94)90056-6  0.76
1994 Prokai-Tatrai K, Zoltewicz JA, Kem WR. Synthesis and conformational analysis of a bridged anabasine and related compounds. A nuclear magnetic resonance spectroscopy and molecular modeling study Tetrahedron. 50: 9909-9918. DOI: 10.1016/S0040-4020(01)89606-X  0.76
1993 Kem WR, Östman C. Evidence for a FMRFamide-like peptide in the heteronemertine Cerebratulus lacteus Leidy Hydrobiologia. 266: 247-254. DOI: 10.1007/978-94-011-2052-4_18  0.76
1992 Pennington MW, Festin SM, Maccecchini ML, Kem WR. Synthesis and characterization of a disulfide bond isomer of omega-conotoxin GVIA. Toxicon : Official Journal of the International Society On Toxinology. 30: 755-64. PMID 1509493 DOI: 10.1016/0041-0101(92)90009-T  0.76
1992 Salgado VL, Kem WR. Actions of three structurally distinct sea anemone toxins on crustacean and insect sodium channels. Toxicon : Official Journal of the International Society On Toxinology. 30: 1365-81. PMID 1336629 DOI: 10.1016/0041-0101(92)90512-4  0.76
1992 Hansen PE, Kem WR, Bieber AL, Norton RS. 1H-NMR study of neurotoxin B-IV from the marine worm Cerebratulus lacteus. Solution properties, sequence-specific resonance assignments, secondary structure and global fold. European Journal of Biochemistry / Febs. 210: 231-40. PMID 1332861 DOI: 10.1111/J.1432-1033.1992.Tb17413.X  0.76
1990 Kovacic P, Kassel MA, Castonguay A, Kem WR, Feinberg BA. Reduction potentials of imine-substituted, biologically active pyridines: possible relation to activity. Free Radical Research Communications. 10: 185-92. PMID 2397922 DOI: 10.3109/10715769009149887  0.76
1990 Kem WR, Tu CK, Williams RW, Toumadje A, Johnson WC. Circular dichroism and laser Raman spectroscopic analysis of the secondary structure of Cerebratulus lacteus toxin B-IV Journal of Protein Chemistry. 9: 433-443. PMID 2275754 DOI: 10.1007/Bf01024619  0.76
1990 Pennington MW, Kem WR, Dunn BM. Synthesis and biological activity of six monosubstituted analogs of a sea anemone polypeptide neurotoxin Peptide Research. 3: 228-232. PMID 2134066  0.76
1990 Pennington MW, Kem WR, Norton RS, Dunn BM. Chemical synthesis of a neurotoxic polypeptide from the sea anemone Stichodactyla helianthus International Journal of Peptide and Protein Research. 36: 335-343. PMID 1981881 DOI: 10.1111/J.1399-3011.1990.Tb01291.X  0.76
1990 Hellberg S, Kem WR. Quantitative structure-activity relationships for sea anemone polypeptide toxins. International Journal of Peptide and Protein Research. 36: 440-4. PMID 1980491 DOI: 10.1111/J.1399-3011.1990.Tb01303.X  0.76
1990 Fogh RH, Kem WR, Norton RS. Solution structure of neurotoxin I from the sea anemone Stichodactyla helianthus. A nuclear magnetic resonance, distance geometry, and restrained molecular dynamics study. The Journal of Biological Chemistry. 265: 13016-28. PMID 1973932 DOI: 10.2210/Pdb2Sh1/Pdb  0.76
1990 Zoltewicz JA, Bloom LB, Kem WR. Hydrolysis of cholinergic anabaseine and N-methylanabaseine: Influence of cosolvents on the position of the ring-chain equilibrium-Compensatory changes Bioorganic Chemistry. 18: 395-412. DOI: 10.1016/0045-2068(90)90023-X  0.76
1989 Doyle JW, Kem WR. Binding of a radiolabeled sea anemone cytolysin to erythrocyte membranes. Biochimica Et Biophysica Acta. 987: 181-6. PMID 2574996 DOI: 10.1016/0005-2736(89)90542-7  0.76
1989 Kem WR, Parten B, Pennington MW, Price DA, Dunn BM. Isolation, characterization, and amino acid sequence of a polypeptide neurotoxin occurring in the sea anemone Stichodactyla helianthus Biochemistry. 28: 3483-3489. PMID 2568126 DOI: 10.1021/Bi00434A050  0.76
1989 Doyle JW, Kem WR, Vilallonga FA. Interfacial activity of an ion channel-generating protein cytolysin from the sea anemone Stichodactyla helianthus. Toxicon : Official Journal of the International Society On Toxinology. 27: 465-71. PMID 2567077 DOI: 10.1016/0041-0101(89)90209-2  0.76
1989 Fogh RH, Mabbutt BC, Kem WR, Norton RS. Sequence-specific 1H NMR assignments and secondary structure in the sea anemone polypeptide Stichodactyla helianthus neurotoxin I. Biochemistry. 28: 1826-34. PMID 2566324 DOI: 10.1021/Bi00430A060  0.76
1989 Norton RS, Cossins AI, Kem WR. 1H NMR study of the solution properties of the polypeptide neurotoxin I from the sea anemone Stichodactyla helianthus. Biochemistry. 28: 1820-6. PMID 2566323 DOI: 10.1021/Bi00430A059  0.76
1988 Kem WR, Dunn BM. Separation and characterization of four different amino acid sequence variants of a sea anemone (Stichodactyla helianthus) protein cytolysin Toxicon. 26: 997-1008. PMID 2907688 DOI: 10.1016/0041-0101(88)90198-5  0.76
1988 Kem WR. Pyridine alkaloid distribution in the hoplonemertines Hydrobiologia. 156: 145-151. DOI: 10.1007/978-94-009-4063-5_17  0.76
1987 Meyer EM, Arendash GW, Judkins JH, Ying L, Wade C, Kem WR. Effects of nucleus basalis lesions on the muscarinic and nicotinic modulation of [3H]acetylcholine release in the rat cerebral cortex Journal of Neurochemistry. 49: 1758-1762. PMID 3681294 DOI: 10.1111/J.1471-4159.1987.Tb02433.X  0.76
1985 Kem WR. Structure and action of nemertine toxins Integrative and Comparative Biology. 25: 99-111. DOI: 10.1093/Icb/25.1.99  0.76
1983 Kuo JF, Raynor RL, Mazzei GJ, Schatzman RC, Turner RS, Kem WR. Cobra polypeptide cytotoxin I and marine worm polypeptide cytotoxin A-IV are potent and selective inhibitors of phospholipid-sensitive Ca2+-dependent protein kinase. Febs Letters. 153: 183-6. PMID 6298006 DOI: 10.1016/0014-5793(83)80144-6  0.76
1980 Blumenthal KM, Kem WR. Structure and action of heteronemertine polypeptide toxins: inactivation of Cerebratulus lacteus toxin B-IV by tyrosine nitration. Archives of Biochemistry and Biophysics. 203: 816-21. PMID 7458356 DOI: 10.1016/0003-9861(80)90243-X  0.76
1978 Posner P, Kem WR. Cardiac effects of toxin A-III from the heteronemertine worm Cerebratulus lacteus (Leidy). Toxicon : Official Journal of the International Society On Toxinology. 16: 343-9. PMID 684765 DOI: 10.1016/0041-0101(78)90154-X  0.76
1976 Kem WR, Scott KN, Duncan JH. Hoplonemertine worms-a new source of pyridine neurotoxins Experientia. 32: 684-686. PMID 181266 DOI: 10.1007/BF01919831  0.76
1971 Kem WR. A study of the occurrence of anabaseine in Paranemertes and other nemertines. Toxicon : Official Journal of the International Society On Toxinology. 9: 23-32. PMID 5539373 DOI: 10.1016/0041-0101(71)90040-7  0.76
1971 Coates RM, Kem WR, Abbott BC. Isolation and structure of a hoplonemertine toxin. Toxicon : Official Journal of the International Society On Toxinology. 9: 15-22. PMID 5539371 DOI: 10.1016/0041-0101(71)90039-0  0.76
Show low-probability matches.