Year |
Citation |
Score |
2022 |
Strom A, Shah R, Dolot R, Rogers MS, Tong CL, Wang D, Xia Y, Lipscomb JD, Wagner CR. Dynamic Long-Range Interactions Influence Substrate Binding and Catalysis by Human Histidine Triad Nucleotide-Binding Proteins (HINTs), Key Regulators of Multiple Cellular Processes and Activators of Antiviral ProTides. Biochemistry. PMID 36398895 DOI: 10.1021/acs.biochem.2c00506 |
0.673 |
|
2022 |
Wang Y, Wagner CR, Distefano MD. Manipulating Cell Fates with Protein Conjugates. Bioconjugate Chemistry. PMID 35969811 DOI: 10.1021/acs.bioconjchem.2c00226 |
0.315 |
|
2021 |
Strom A, Shah R, Wagner CR. "Switching On" Enzyme Substrate Specificity Analysis with a Fluorescent Competitive Inhibitor. Biochemistry. PMID 33513008 DOI: 10.1021/acs.biochem.0c00954 |
0.655 |
|
2020 |
Kilic O, Matos de Souza MR, Almotlak A, Wang Y, Siegfried J, Distefano MD, Wagner CR. Anti-EGFR Fibronectin Bispecific Chemically Self-Assembling Nanorings (CSANs) Induce Potent T-cell Mediated Anti-Tumor Response and Downregulation of EGFR Signaling and PD-1/PD-L1 Expression. Journal of Medicinal Chemistry. PMID 32852209 DOI: 10.1021/Acs.Jmedchem.0C00489 |
0.339 |
|
2019 |
Shah R, Peterson C, Strom A, Dillenburg M, Finzel BC, Kitto KF, Fairbanks CA, Wilcox GL, Wagner CR. Inhibition of Hint1 Modulates Spinal Nociception and NMDA Evoked Behavior in Mice. Acs Chemical Neuroscience. PMID 31503445 DOI: 10.1021/Acschemneuro.9B00432 |
0.644 |
|
2018 |
Csizmar CM, Petersburg J, Perry TJ, Rozumalski L, Hackel BJ, Wagner CR. Multivalent Ligand Binding to Cell Membrane Antigens: Defining the Interplay of Affinity, Valency, and Expression Density. Journal of the American Chemical Society. PMID 30507196 DOI: 10.1021/Jacs.8B09198 |
0.381 |
|
2018 |
Csizmar CM, Petersburg JR, Wagner CR. Programming Cell-Cell Interactions through Non-genetic Membrane Engineering. Cell Chemical Biology. PMID 29909993 DOI: 10.1016/J.Chembiol.2018.05.009 |
0.321 |
|
2018 |
Petersburg J, Shen J, Csizmar CM, Murphy KA, Spanier J, Gabrielse K, Griffith TS, Fife B, Wagner CR. Eradication of Established Tumors by Chemically Self-Assembled Nanoring (CSAN) Targeted T-cells. Acs Nano. PMID 29792808 DOI: 10.1021/Acsnano.8B01308 |
0.756 |
|
2018 |
Shah RM, Maize KM, West HT, Strom AM, Finzel BC, Wagner CR. Structure and Functional Characterization of Human Histidine Triad Nucleotide Binding Protein 1 Mutations Associated with Inherited Axonal Neuropathy with Neuromyotonia. Journal of Molecular Biology. PMID 29787766 DOI: 10.1016/J.Jmb.2018.05.028 |
0.68 |
|
2018 |
West HT, Csizmar CM, Wagner CR. Tunable Supramolecular Assemblies from Amphiphilic Nucleoside Phosphoramidate Nanofibers by Enzyme Activation. Biomacromolecules. PMID 29689161 DOI: 10.1021/Acs.Biomac.8B00254 |
0.394 |
|
2018 |
Csizmar CM, Petersburg J, Hendricks A, Stern LA, Hackel BJ, Wagner CR. Engineering Reversible Cell-Cell Interactions with Lipid Anchored Prosthetic Receptors. Bioconjugate Chemistry. PMID 29537253 DOI: 10.1021/Acs.Bioconjchem.8B00058 |
0.362 |
|
2017 |
Shah R, Zhou A, Wagner CR. Switch-on fluorescent/FRET probes to study human histidine triad nucleotide binding protein 1 (hHint1), a novel target for opioid tolerance and neuropathic pain. Organic & Biomolecular Chemistry. 15: 10230-10237. PMID 29177353 DOI: 10.1039/C7Ob02472J |
0.685 |
|
2017 |
Maize KM, Shah R, Strom A, Kumarapperuma SC, Zhou AL, Wagner CR, Finzel BC. A Crystal Structure-Based Guide to the Design of Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) Activated ProTides. Molecular Pharmaceutics. PMID 28968488 DOI: 10.1021/Acs.Molpharmaceut.7B00664 |
0.788 |
|
2017 |
Okon A, Matos de Souza MR, Shah R, Amorim R, da Costa LJ, Wagner CR. Anchimerically Activatable Antiviral ProTides. Acs Medicinal Chemistry Letters. 8: 958-962. PMID 28947944 DOI: 10.1021/Acsmedchemlett.7B00277 |
0.665 |
|
2017 |
Okon A, Han J, Dawadi S, Demosthenous C, Aldrich CC, Gupta M, Wagner CR. Anchimerically Activated ProTides as Inhibitors of Cap-Dependent Translation and Inducers of Chemosensitization in Mantle Cell Lymphoma. Journal of Medicinal Chemistry. PMID 28858511 DOI: 10.1021/Acs.Jmedchem.7B00916 |
0.375 |
|
2017 |
Shah R, Chou TF, Maize KM, Strom A, Finzel BC, Wagner CR. Inhibition by divalent metal ions of human histidine triad nucleotide binding protein1 (hHint1), a regulator of opioid analgesia and neuropathic pain. Biochemical and Biophysical Research Communications. PMID 28739258 DOI: 10.1016/J.Bbrc.2017.07.111 |
0.714 |
|
2017 |
Shah R, Maize KM, Zhou X, Finzel BC, Wagner CR. Caught before Released: Structural Mapping of the Reaction Trajectory for the Sofosbuvir Activating Enzyme, Human Histidine Triad Nucleotide Binding Protein 1 (hHint1). Biochemistry. PMID 28691797 DOI: 10.1021/Acs.Biochem.7B00148 |
0.711 |
|
2017 |
Stern LA, Csizmar CM, Woldring DR, Wagner CR, Hackel BJ. Titratable Avidity Reduction Enhances Affinity Discrimination in Mammalian Cellular Selections of Yeast-Displayed Ligands. Acs Combinatorial Science. PMID 28322543 DOI: 10.1021/Acscombsci.6B00191 |
0.347 |
|
2017 |
Maize KM, Shah R, Strom A, Kumarapperuma S, Wagner CR, Finzel BC. A structure-based guide to building hHint-1 activated nucleotide prodrugs Acta Crystallographica Section a Foundations and Advances. 73: a300-a300. DOI: 10.1107/S0108767317097069 |
0.749 |
|
2016 |
Shah R, Strom A, Zhou A, Maize KM, Finzel BC, Wagner CR. Design, Synthesis, and Characterization of Sulfamide and Sulfamate Nucleotidomimetic Inhibitors of hHint1. Acs Medicinal Chemistry Letters. 7: 780-4. PMID 27563403 DOI: 10.1021/Acsmedchemlett.6B00169 |
0.667 |
|
2016 |
Shah R, Petersburg J, Gangar AC, Fegan A, Wagner CR, Kumarapperuma SC. In vivo Evaluation of Site-specifically PEGylated Chemically Self-assembled Protein Nanostructures. Molecular Pharmaceutics. PMID 26985775 DOI: 10.1021/Acs.Molpharmaceut.6B00110 |
0.772 |
|
2015 |
Shen J, Vallera DA, Wagner CR. Prosthetic Antigen Receptors. Journal of the American Chemical Society. PMID 26230248 DOI: 10.1021/Jacs.5B06166 |
0.338 |
|
2015 |
Garzón J, Herrero-Labrador R, Rodríguez-Muñoz M, Shah R, Vicente-Sánchez A, Wagner CR, Sánchez-Blázquez P. HINT1 protein: a new therapeutic target to enhance opioid antinociception and block mechanical allodynia. Neuropharmacology. 89: 412-23. PMID 25445489 DOI: 10.1016/J.Neuropharm.2014.10.022 |
0.655 |
|
2014 |
Chen EZ, Jacobson BA, Patel MR, Okon AM, Li S, Xiong K, Vaidya AJ, Bitterman PB, Wagner CR, Kratzke RA. Small-molecule inhibition of oncogenic eukaryotic protein translation in mesothelioma cells. Investigational New Drugs. 32: 598-603. PMID 24711125 DOI: 10.1007/S10637-014-0076-7 |
0.351 |
|
2014 |
Gabrielse K, Gangar A, Kumar N, Lee JC, Fegan A, Shen JJ, Li Q, Vallera D, Wagner CR. Reversible re-programing of cell-cell interactions. Angewandte Chemie (International Ed. in English). 53: 5112-6. PMID 24700601 DOI: 10.1002/Anie.201310645 |
0.733 |
|
2014 |
Cao J, He L, Lin G, Hu C, Dong R, Zhang J, Zhu H, Hu Y, Wagner CR, He Q, Yang B. Cap-dependent translation initiation factor, eIF4E, is the target for Ouabain-mediated inhibition of HIF-1α. Biochemical Pharmacology. 89: 20-30. PMID 24345331 DOI: 10.1016/J.Bcp.2013.12.002 |
0.331 |
|
2013 |
Rashidian M, Kumarapperuma SC, Gabrielse K, Fegan A, Wagner CR, Distefano MD. Simultaneous dual protein labeling using a triorthogonal reagent. Journal of the American Chemical Society. 135: 16388-96. PMID 24134212 DOI: 10.1021/Ja403813B |
0.756 |
|
2013 |
Gangar A, Fegan A, Kumarapperuma SC, Huynh P, Benyumov A, Wagner CR. Targeted delivery of antisense oligonucleotides by chemically self-assembled nanostructures. Molecular Pharmaceutics. 10: 3514-8. PMID 23829765 DOI: 10.1021/Mp400164F |
0.775 |
|
2013 |
Maize KM, Wagner CR, Finzel BC. Structural characterization of human histidine triad nucleotide-binding protein 2, a member of the histidine triad superfamily. The Febs Journal. 280: 3389-98. PMID 23659632 DOI: 10.1111/Febs.12330 |
0.395 |
|
2013 |
Zhou X, Chou TF, Aubol BE, Park CJ, Wolfenden R, Adams J, Wagner CR. Kinetic mechanism of human histidine triad nucleotide binding protein 1. Biochemistry. 52: 3588-600. PMID 23614568 DOI: 10.1021/Bi301616C |
0.634 |
|
2013 |
Rashidian M, Mahmoodi MM, Shah R, Dozier JK, Wagner CR, Distefano MD. A highly efficient catalyst for oxime ligation and hydrazone-oxime exchange suitable for bioconjugation. Bioconjugate Chemistry. 24: 333-42. PMID 23425124 DOI: 10.1021/Bc3004167 |
0.689 |
|
2013 |
Li S, Jia Y, Jacobson B, McCauley J, Kratzke R, Bitterman PB, Wagner CR. Treatment of breast and lung cancer cells with a N-7 benzyl guanosine monophosphate tryptamine phosphoramidate pronucleotide (4Ei-1) results in chemosensitization to gemcitabine and induced eIF4E proteasomal degradation. Molecular Pharmaceutics. 10: 523-31. PMID 23289910 DOI: 10.1021/Mp300699D |
0.511 |
|
2012 |
Fegan A, Kumarapperuma SC, Wagner CR. Chemically self-assembled antibody nanostructures as potential drug carriers. Molecular Pharmaceutics. 9: 3218-27. PMID 23013206 DOI: 10.1021/Mp300303K |
0.793 |
|
2012 |
White BR, Carlson JC, Kerns JL, Wagner CR. Protein interface remodeling in a chemically induced protein dimer. Journal of Molecular Recognition : Jmr. 25: 393-403. PMID 22733548 DOI: 10.1002/Jmr.2196 |
0.625 |
|
2012 |
Jia Y, Polunovsky V, Bitterman PB, Wagner CR. Cap-dependent translation initiation factor eIF4E: an emerging anticancer drug target. Medicinal Research Reviews. 32: 786-814. PMID 22495651 DOI: 10.1002/Med.21260 |
0.487 |
|
2012 |
Gangar A, Fegan A, Kumarapperuma SC, Wagner CR. Programmable self-assembly of antibody-oligonucleotide conjugates as small molecule and protein carriers. Journal of the American Chemical Society. 134: 2895-7. PMID 22296405 DOI: 10.1021/Ja210894G |
0.776 |
|
2012 |
Bardaweel SK, Ghosh B, Wagner CR. Synthesis and evaluation of potential inhibitors of human and Escherichia coli histidine triad nucleotide binding proteins. Bioorganic & Medicinal Chemistry Letters. 22: 558-60. PMID 22104145 DOI: 10.1016/J.Bmcl.2011.10.082 |
0.393 |
|
2011 |
Bardaweel S, Ghosh B, Chou TF, Sadowsky MJ, Wagner CR. E. coli histidine triad nucleotide binding protein 1 (ecHinT) is a catalytic regulator of D-alanine dehydrogenase (DadA) activity in vivo. Plos One. 6: e20897. PMID 21754980 DOI: 10.1371/Journal.Pone.0020897 |
0.587 |
|
2011 |
White BR, Li Q, Wagner CR. Chemically induced self-assembly of enzyme nanorings. Methods in Molecular Biology (Clifton, N.J.). 743: 17-26. PMID 21553179 DOI: 10.1007/978-1-61779-132-1_2 |
0.407 |
|
2011 |
Birkus G, Kutty N, Frey CR, Shribata R, Chou T, Wagner C, McDermott M, Cihlar T. Role of cathepsin A and lysosomes in the intracellular activation of novel antipapillomavirus agent GS-9191 Antimicrobial Agents and Chemotherapy. 55: 2166-2173. PMID 21383096 DOI: 10.1128/Aac.01603-10 |
0.6 |
|
2010 |
Li Q, So CR, Fegan A, Cody V, Sarikaya M, Vallera DA, Wagner CR. Chemically self-assembled antibody nanorings (CSANs): design and characterization of an anti-CD3 IgM biomimetic. Journal of the American Chemical Society. 132: 17247-57. PMID 21077608 DOI: 10.1021/Ja107153A |
0.354 |
|
2010 |
Bardaweel S, Pace J, Chou TF, Cody V, Wagner CR. Probing the impact of the echinT C-terminal domain on structure and catalysis. Journal of Molecular Biology. 404: 627-38. PMID 20934431 DOI: 10.1016/J.Jmb.2010.09.066 |
0.569 |
|
2010 |
Fegan A, White B, Carlson JC, Wagner CR. Chemically controlled protein assembly: techniques and applications. Chemical Reviews. 110: 3315-36. PMID 20353181 DOI: 10.1021/Cr8002888 |
0.566 |
|
2010 |
Jia Y, Chiu TL, Amin EA, Polunovsky V, Bitterman PB, Wagner CR. Design, synthesis and evaluation of analogs of initiation factor 4E (eIF4E) cap-binding antagonist Bn7-GMP. European Journal of Medicinal Chemistry. 45: 1304-13. PMID 20060622 DOI: 10.1016/J.Ejmech.2009.11.054 |
0.513 |
|
2009 |
Zhou X, Zhang N, Liu L, Walters KJ, Hanna PE, Wagner CR. Probing the catalytic potential of the hamster arylamine N-acetyltransferase 2 catalytic triad by site-directed mutagenesis of the proximal conserved residue, Tyr190. The Febs Journal. 276: 6928-41. PMID 19860825 DOI: 10.1111/J.1742-4658.2009.07389.X |
0.448 |
|
2009 |
Liu L, Wagner CR, Hanna PE. Isoform-selective inactivation of human arylamine N-acetyltransferases by reactive metabolites of carcinogenic arylamines. Chemical Research in Toxicology. 22: 1962-74. PMID 19842618 DOI: 10.1021/Tx9002676 |
0.324 |
|
2009 |
Cheng J, Zhou X, Chou TF, Ghosh B, Liu B, Wagner CR. Identification of the amino acid-AZT-phosphoramidase by affinity T7 phage display selection. Bioorganic & Medicinal Chemistry Letters. 19: 6379-81. PMID 19825512 DOI: 10.1016/J.Bmcl.2009.09.067 |
0.607 |
|
2009 |
Ghosh B, Benyumov AO, Ghosh P, Jia Y, Avdulov S, Dahlberg PS, Peterson M, Smith K, Polunovsky VA, Bitterman PB, Wagner CR. Nontoxic chemical interdiction of the epithelial-to-mesenchymal transition by targeting cap-dependent translation. Acs Chemical Biology. 4: 367-77. PMID 19351181 DOI: 10.1021/Cb9000475 |
0.483 |
|
2008 |
Chou TF, So C, White BR, Carlson JC, Sarikaya M, Wagner CR. Enzyme nanorings. Acs Nano. 2: 2519-25. PMID 19206287 DOI: 10.1021/nn800577h |
0.677 |
|
2008 |
Li Q, Hapka D, Chen H, Vallera DA, Wagner CR. Self-assembly of antibodies by chemical induction. Angewandte Chemie (International Ed. in English). 47: 10179-82. PMID 19025747 DOI: 10.1002/Anie.200803507 |
0.31 |
|
2008 |
Liu L, Wagner CR, Hanna PE. Human arylamine N-acetyltransferase 1: in vitro and intracellular inactivation by nitrosoarene metabolites of toxic and carcinogenic arylamines. Chemical Research in Toxicology. 21: 2005-16. PMID 18759501 DOI: 10.1021/Tx800215H |
0.344 |
|
2008 |
Ghosh P, Cheng J, Chou TF, Jia Y, Avdulov S, Bitterman PB, Polunovsky VA, Wagner CR. Expression, purification and characterization of recombinant mouse translation initiation factor eIF4E as a dihydrofolate reductase (DHFR) fusion protein. Protein Expression and Purification. 60: 132-9. PMID 18479935 DOI: 10.1016/J.Pep.2008.03.024 |
0.664 |
|
2007 |
Chou TF, Sham YY, Wagner CR. Impact of the C-terminal loop of histidine triad nucleotide binding protein1 (Hint1) on substrate specificity. Biochemistry. 46: 13074-9. PMID 17939685 DOI: 10.1021/Bi701244H |
0.568 |
|
2007 |
Chou TF, Cheng J, Tikh IB, Wagner CR. Evidence that human histidine triad nucleotide binding protein 3 (Hint3) is a distinct branch of the histidine triad (HIT) superfamily. Journal of Molecular Biology. 373: 978-89. PMID 17870088 DOI: 10.1016/J.Jmb.2007.08.023 |
0.614 |
|
2007 |
Liu L, Von Vett A, Zhang N, Walters KJ, Wagner CR, Hanna PE. Arylamine N-acetyltransferases: characterization of the substrate specificities and molecular interactions of environmental arylamines with human NAT1 and NAT2. Chemical Research in Toxicology. 20: 1300-8. PMID 17672512 DOI: 10.1021/Tx7001614 |
0.368 |
|
2007 |
Minchin RF, Hanna PE, Dupret JM, Wagner CR, Rodrigues-Lima F, Butcher NJ. Arylamine N-acetyltransferase I. The International Journal of Biochemistry & Cell Biology. 39: 1999-2005. PMID 17392017 DOI: 10.1016/J.Biocel.2006.12.006 |
0.321 |
|
2007 |
Chou TF, Tikh IB, Horta BA, Ghosh B, De Alencastro RB, Wagner CR. Engineered monomeric human histidine triad nucleotide-binding protein 1 hydrolyzes fluorogenic acyl-adenylate and lysyl-tRNA synthetase-generated lysyl-adenylate. The Journal of Biological Chemistry. 282: 15137-47. PMID 17337452 DOI: 10.1074/Jbc.M606972200 |
0.557 |
|
2007 |
Chou TF, Baraniak J, Kaczmarek R, Zhou X, Cheng J, Ghosh B, Wagner CR. Phosphoramidate pronucleotides: a comparison of the phosphoramidase substrate specificity of human and Escherichia coli histidine triad nucleotide binding proteins. Molecular Pharmaceutics. 4: 208-17. PMID 17217311 DOI: 10.1021/Mp060070Y |
0.632 |
|
2007 |
Chou TF, Wagner CR. Lysyl-tRNA synthetase-generated lysyl-adenylate is a substrate for histidine triad nucleotide binding proteins. The Journal of Biological Chemistry. 282: 4719-27. PMID 17158446 DOI: 10.1074/Jbc.M610530200 |
0.61 |
|
2006 |
Poria RB, Norenberg JP, Anderson TL, Erion J, Wagner CR, Arterburn JB, Larson RS. Characterization of a radiolabeled small molecule targeting leukocyte function-associated antigen-1 expression in lymphoma and leukemia. Cancer Biotherapy & Radiopharmaceuticals. 21: 418-26. PMID 17105416 DOI: 10.1089/Cbr.2006.21.418 |
0.652 |
|
2006 |
Zhang N, Liu L, Liu F, Wagner CR, Hanna PE, Walters KJ. NMR-based model reveals the structural determinants of mammalian arylamine N-acetyltransferase substrate specificity. Journal of Molecular Biology. 363: 188-200. PMID 16959263 DOI: 10.1016/J.Jmb.2006.08.026 |
0.348 |
|
2006 |
Liu F, Zhang N, Zhou X, Hanna PE, Wagner CR, Koepp DM, Walters KJ. Arylamine N-acetyltransferase aggregation and constitutive ubiquitylation. Journal of Molecular Biology. 361: 482-92. PMID 16857211 DOI: 10.1016/J.Jmb.2006.06.029 |
0.432 |
|
2006 |
Carlson JC, Jena SS, Flenniken M, Chou TF, Siegel RA, Wagner CR. Chemically controlled self-assembly of protein nanorings. Journal of the American Chemical Society. 128: 7630-8. PMID 16756320 DOI: 10.1021/Ja060631E |
0.713 |
|
2005 |
Wang H, Liu L, Hanna PE, Wagner CR. Catalytic mechanism of hamster arylamine N-acetyltransferase 2. Biochemistry. 44: 11295-306. PMID 16101314 DOI: 10.1021/Bi047564Q |
0.544 |
|
2005 |
Wang H, Vath GM, Kawamura A, Bates CA, Sim E, Hanna PE, Wagner CR. Over-expression, purification, and characterization of recombinant human arylamine N-acetyltransferase 1. The Protein Journal. 24: 65-77. PMID 16003948 DOI: 10.1007/S10930-004-1513-9 |
0.586 |
|
2005 |
Ghosh P, Park C, Peterson MS, Bitterman PB, Polunovsky VA, Wagner CR. Synthesis and evaluation of potential inhibitors of eIF4E cap binding to 7-methyl GTP. Bioorganic & Medicinal Chemistry Letters. 15: 2177-80. PMID 15808492 DOI: 10.1016/J.Bmcl.2005.01.080 |
0.306 |
|
2005 |
Larson RS, Davis T, Bologa C, Semenuk G, Vijayan S, Li Y, Oprea T, Chigaev A, Buranda T, Wagner CR, Sklar LA. Dissociation of I domain and global conformational changes in LFA-1: refinement of small molecule-I domain structure-activity relationships. Biochemistry. 44: 4322-31. PMID 15766261 DOI: 10.1021/Bi048187K |
0.359 |
|
2005 |
Wang H, Wagner CR, Hanna PE. Irreversible inactivation of arylamine N-acetyltransferases in the presence of N-hydroxy-4-acetylaminobiphenyl: a comparison of human and hamster enzymes. Chemical Research in Toxicology. 18: 183-97. PMID 15720122 DOI: 10.1021/Tx049801W |
0.535 |
|
2005 |
Chou TF, Bieganowski P, Shilinski K, Cheng J, Brenner C, Wagner CR. 31P NMR and genetic analysis establish hinT as the only Escherchia coli purine nucleoside phosphoramidase and as essential for growth under high salt conditions. The Journal of Biological Chemistry. 280: 15356-61. PMID 15703176 DOI: 10.1074/Jbc.M500434200 |
0.588 |
|
2005 |
Kawamura A, Graham J, Mushtaq A, Tsiftsoglou SA, Vath GM, Hanna PE, Wagner CR, Sim E. Eukaryotic arylamine N-acetyltransferase. Investigation of substrate specificity by high-throughput screening. Biochemical Pharmacology. 69: 347-59. PMID 15627487 DOI: 10.1016/J.Bcp.2004.09.014 |
0.347 |
|
2005 |
Wang H, Liu L, Hanna PE, Wagner CR. Erratum: Catalytic mechanism of hamster arylamine N-acetyltransferase 2 (Biochemistry (August 23, 2005) 44, 3 (11295-11306)) Biochemistry. 44. DOI: 10.1021/Bi0580310 |
0.503 |
|
2004 |
Kim J, Chou TF, Griesgraber GW, Wagner CR. Direct measurement of nucleoside monophosphate delivery from a phosphoramidate pronucleotide by stable isotope labeling and LC-ESI(-)-MS/MS. Molecular Pharmaceutics. 1: 102-11. PMID 15832506 DOI: 10.1021/Mp0340338 |
0.529 |
|
2004 |
Wang H, Vath GM, Gleason KJ, Hanna PE, Wagner CR. Probing the mechanism of hamster arylamine N-acetyltransferase 2 acetylation by active site modification, site-directed mutagenesis, and pre-steady state and steady state kinetic studies. Biochemistry. 43: 8234-46. PMID 15209520 DOI: 10.1021/Bi0497244 |
0.57 |
|
2004 |
Wang H, Guo Z, Vath GM, Wagner CR, Hanna PE. Chemical modification of hamster arylamine N-acetyltransferase 2 with isozyme-selective and nonselective N-arylbromoacetamido reagents. The Protein Journal. 23: 153-66. PMID 15106881 DOI: 10.1023/B:Jopc.0000020082.14480.E2 |
0.572 |
|
2004 |
Annis DA, Athanasopoulos J, Curran PJ, Felsch JS, Kalghatgi K, Lee WH, Nash HM, Orminati JPA, Rosner KE, Shipps GW, Thaddupathy GRA, Tyler AN, Vilenchik L, Wagner CR, Wintner EA. An affinity selection-mass spectrometry method for the identification of small molecule ligands from self-encoded combinatorial libraries: Discovery of a novel antagonist of E. coli dihydrofolate reductase International Journal of Mass Spectrometry. 238: 77-83. DOI: 10.1016/J.Ijms.2003.11.022 |
0.336 |
|
2003 |
Guo Z, Vath GM, Wagner CR, Hanna PE. Arylamine N-acetyltransferases: covalent modification and inactivation of hamster NAT1 by bromoacetamido derivatives of aniline and 2-aminofluorene. Journal of Protein Chemistry. 22: 631-42. PMID 14714730 DOI: 10.1023/B:Jopc.0000008728.17159.Dd |
0.301 |
|
2003 |
Pineda P, Kanter A, McIvor RS, Benkovic SJ, Rosowsky A, Wagner CR. Dihydrofolate reductase mutant with exceptional resistance to methotrexate but not to trimetrexate. Journal of Medicinal Chemistry. 46: 2816-8. PMID 12825924 DOI: 10.1021/Jm034057I |
0.448 |
|
2003 |
Carlson JC, Kanter A, Thuduppathy GR, Cody V, Pineda PE, McIvor RS, Wagner CR. Designing protein dimerizers: the importance of ligand conformational equilibria. Journal of the American Chemical Society. 125: 1501-7. PMID 12568609 DOI: 10.1021/Ja026264Y |
0.595 |
|
2002 |
Song H, Griesgraber GW, Wagner CR, Zimmerman CL. Pharmacokinetics of amino acid phosphoramidate monoesters of zidovudine in rats. Antimicrobial Agents and Chemotherapy. 46: 1357-63. PMID 11959569 DOI: 10.1128/Aac.46.5.1357-1363.2002 |
0.319 |
|
2001 |
Chiaramonte M, Koviach JL, Moore C, Iyer VV, Wagner CR, Halcomb RL, Miller W, Melançon P, Kuchta RD. Inhibition of CMP-sialic acid transport into Golgi vesicles by nucleoside monophosphates. Biochemistry. 40: 14260-7. PMID 11714280 DOI: 10.1021/Bi011262W |
0.319 |
|
2000 |
Iyer VV, Griesgraber GW, Radmer MR, McIntee EJ, Wagner CR. Synthesis, in vitro anti-breast cancer activity, and intracellular decomposition of amino acid methyl ester and alkyl amide phosphoramidate monoesters of 3'-azido-3'-deoxythymidine (AZT). Journal of Medicinal Chemistry. 43: 2266-74. PMID 10841805 DOI: 10.1021/Jm000110G |
0.312 |
|
1999 |
Wagner CR, Chang SL, Griesgraber GW, Song H, McIntee EJ, Zimmerman CL. Antiviral nucleoside drug delivery via amino acid phosphoramidates. Nucleosides & Nucleotides. 18: 913-9. PMID 10432709 DOI: 10.1080/15257779908041599 |
0.32 |
|
1997 |
McIntee EJ, Remmel RP, Schinazi RF, Abraham TW, Wagner CR. Probing the mechanism of action and decomposition of amino acid phosphomonoester amidates of antiviral nucleoside prodrugs. Journal of Medicinal Chemistry. 40: 3323-31. PMID 9341906 DOI: 10.1021/Jm960694F |
0.328 |
|
1997 |
Sticha KR, Sieg CA, Bergstrom CP, Hanna PE, Wagner CR. Overexpression and large-scale purification of recombinant hamster polymorphic arylamine N-acetyltransferase as a dihydrofolate reductase fusion protein. Protein Expression and Purification. 10: 141-53. PMID 9179301 DOI: 10.1006/Prep.1997.0734 |
0.401 |
|
1997 |
Abraham TW, McIntee EJ, Iyer VV, Schinazi RF, Wagner CR. Synthesis, biological activity and decomposition studies of amino acid phosphomonoester amidates of acyclovir Nucleosides and Nucleotides. 16: 2079-2092. DOI: 10.1080/07328319708002557 |
0.329 |
|
1996 |
Abraham TW, Kalman TI, McIntee EJ, Wagner CR. Synthesis and biological activity of aromatic amino acid phosphoramidates of 5-fluoro-2'-deoxyuridine and 1-beta-arabinofuranosylcytosine: evidence of phosphoramidase activity. Journal of Medicinal Chemistry. 39: 4569-75. PMID 8917645 DOI: 10.1021/Jm9603680 |
0.316 |
|
1995 |
Bergstrom CP, Wagner CR, Ann DK, Hanna PE. Hamster monomorphic arylamine N-acetyltransferase: expression in Escherichia coli and purification. Protein Expression and Purification. 6: 45-55. PMID 7756838 DOI: 10.1006/Prep.1995.1007 |
0.373 |
|
1995 |
Wagner CR, Huang Z, Singleton SF, Benkovic SJ. Molecular basis for nonadditive mutational effects in Escherichia coli dihydrofolate reductase. Biochemistry. 34: 15671-80. PMID 7495797 DOI: 10.1021/Bi00048A011 |
0.431 |
|
1994 |
Huang Z, Wagner CR, Benkovic SJ. Nonadditivity of mutational effects at the folate binding site of Escherichia coli dihydrofolate reductase. Biochemistry. 33: 11576-85. PMID 7918371 DOI: 10.1021/Bi00204A020 |
0.445 |
|
1992 |
Wagner CR, Thillet J, Benkovic SJ. Complementary perturbation of the kinetic mechanism and catalytic effectiveness of dihydrofolate reductase by side-chain interchange. Biochemistry. 31: 7834-40. PMID 1510969 DOI: 10.1021/Bi00149A013 |
0.384 |
|
1992 |
Wagner CR, Benkovic SJ. Probing the molecular basis of resistance to pyrimethamine by site-directed mutagenesis. Journal of Medicinal Chemistry. 35: 2912-5. PMID 1495020 DOI: 10.1021/Jm00093A026 |
0.351 |
|
1990 |
Wagner CR, Benkovic SJ. Site directed mutagenesis: a tool for enzyme mechanism dissection. Trends in Biotechnology. 8: 263-70. PMID 1366735 DOI: 10.1016/0167-7799(90)90189-5 |
0.454 |
|
1988 |
Wagner CR, Porter NA. A phospholipase C protocol for phospholipid peroxidation analysis. Chemical Research in Toxicology. 1: 274-80. PMID 2979743 DOI: 10.1021/Tx00005A004 |
0.358 |
|
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