| Year |
Citation |
Score |
| 2017 |
Sanchez S, Rodríguez-Sanoja R, Ramos A, Demain AL. Our microbes not only produce antibiotics, they also overproduce amino acids. The Journal of Antibiotics. PMID 29089597 DOI: 10.1038/Ja.2017.142 |
0.331 |
|
| 2017 |
Falzone M, Crespo E, Jones K, Khan G, Korn VL, Patel A, Patel M, Patel K, Perkins C, Siddiqui S, Stenger D, Yu E, Gelber M, Scheffler R, Nayda V, ... ... Demain AL, et al. Nutritional control of antibiotic production by Streptomyces platensis MA7327: importance of l-aspartic acid. The Journal of Antibiotics. PMID 28465627 DOI: 10.1038/Ja.2017.49 |
0.359 |
|
| 2014 |
Demain AL. Importance of microbial natural products and the need to revitalize their discovery. Journal of Industrial Microbiology & Biotechnology. 41: 185-201. PMID 23990168 DOI: 10.1007/S10295-013-1325-Z |
0.358 |
|
| 2013 |
Falzone M, Martens E, Tynan H, Maggio C, Golden S, Nayda V, Crespo E, Inamine G, Gelber M, Lemence R, Chiappini N, Friedman E, Shen B, Gullo V, Demain AL. Development of a chemically defined medium for the production of the antibiotic platensimycin by Streptomyces platensis. Applied Microbiology and Biotechnology. 97: 9535-9. PMID 24022611 DOI: 10.1007/S00253-013-5201-6 |
0.37 |
|
| 2013 |
Polanski-Cordovano G, Romano L, Marotta LL, Jacob S, Soo Hoo J, Tartaglia E, Asokan D, Kar S, Demain AL. Nutritional studies on production of antibacterial activity by the zebra mussel antagonist, Pseudomonas fluorescens CL0145A. Journal of Microbiology and Biotechnology. 23: 656-60. PMID 23648855 DOI: 10.4014/Jmb.1211.11035 |
0.412 |
|
| 2013 |
Ozcengiz G, Demain AL. Recent advances in the biosynthesis of penicillins, cephalosporins and clavams and its regulation. Biotechnology Advances. 31: 287-311. PMID 23228980 DOI: 10.1016/J.Biotechadv.2012.12.001 |
0.321 |
|
| 2013 |
Aluotto S, Tynan H, Maggio C, Falzone M, Mukherjee A, Gullo V, Demain AL. Development of a semi-defined medium supporting production of platensimycin and platencin by Streptomyces platensis. The Journal of Antibiotics. 66: 51-4. PMID 23188381 DOI: 10.1038/Ja.2012.97 |
0.372 |
|
| 2011 |
Kardos N, Demain AL. Penicillin: the medicine with the greatest impact on therapeutic outcomes. Applied Microbiology and Biotechnology. 92: 677-87. PMID 21964640 DOI: 10.1007/S00253-011-3587-6 |
0.323 |
|
| 2011 |
Martens E, Demain AL. Platensimycin and platencin: promising antibiotics for future application in human medicine. The Journal of Antibiotics. 64: 705-10. PMID 21915133 DOI: 10.1038/Ja.2011.80 |
0.353 |
|
| 2011 |
Vaishnav P, Demain AL. Unexpected applications of secondary metabolites. Biotechnology Advances. 29: 223-9. PMID 21130862 DOI: 10.1016/J.Biotechadv.2010.11.006 |
0.301 |
|
| 2011 |
Sanchez S, Demain AL. Enzymes and Bioconversions of Industrial, Pharmaceutical, and Biotechnological Significance Organic Process Research & Development. 15: 224-230. DOI: 10.1021/Op100302X |
0.324 |
|
| 2010 |
Adrio JL, Demain AL. Recombinant organisms for production of industrial products. Bioengineered Bugs. 1: 116-31. PMID 21326937 DOI: 10.4161/Bbug.1.2.10484 |
0.313 |
|
| 2009 |
Fang A, Gerson DF, Demain AL. Production of Clostridium difficile toxin in a medium totally free of both animal and dairy proteins or digests Proceedings of the National Academy of Sciences of the United States of America. 106: 13225-13229. PMID 19651616 DOI: 10.1073/Pnas.0906425106 |
0.747 |
|
| 2009 |
Liras P, Demain AL. Chapter 16. Enzymology of beta-lactam compounds with cephem structure produced by actinomycete. Methods in Enzymology. 458: 401-29. PMID 19374992 DOI: 10.1016/S0076-6879(09)04816-2 |
0.334 |
|
| 2009 |
Demain AL. Antibiotics: natural products essential to human health. Medicinal Research Reviews. 29: 821-42. PMID 19291695 DOI: 10.1002/Med.20154 |
0.355 |
|
| 2009 |
Demain AL, Sanchez S. Microbial drug discovery: 80 years of progress. The Journal of Antibiotics. 62: 5-16. PMID 19132062 DOI: 10.1038/Ja.2008.16 |
0.304 |
|
| 2008 |
Sanchez S, Demain AL. Metabolic regulation and overproduction of primary metabolites. Microbial Biotechnology. 1: 283-319. PMID 21261849 DOI: 10.1111/J.1751-7915.2007.00015.X |
0.366 |
|
| 2008 |
Demain AL, Adrio JL. Strain improvement for production of pharmaceuticals and other microbial metabolites by fermentation. Progress in Drug Research. Fortschritte Der Arzneimittelforschung. ProgrèS Des Recherches Pharmaceutiques. 65: 251, 253-89. PMID 18084918 DOI: 10.1007/978-3-7643-8117-2_7 |
0.335 |
|
| 2007 |
Demain AL, George S, Kole M, Gerson DF, Fang A. Tetanus toxin production in soy-based medium: nutritional studies and scale-up into small fermentors. Letters in Applied Microbiology. 45: 635-8. PMID 17908228 DOI: 10.1111/J.1472-765X.2007.02238.X |
0.731 |
|
| 2006 |
Fang A, Gerson DF, Demain AL. Menstrum for culture preservation and medium for seed preparation in a tetanus toxin production process containing no animal or dairy products Letters in Applied Microbiology. 43: 360-363. PMID 16965364 DOI: 10.1111/J.1472-765X.2006.01984.X |
0.743 |
|
| 2006 |
Demain AL, Vaishnav P. Involvement of nitrogen-containing compounds in beta-lactam biosynthesis and its control. Critical Reviews in Biotechnology. 26: 67-82. PMID 16809098 DOI: 10.1080/07388550600671466 |
0.334 |
|
| 2006 |
Demain AL, Gerson DF, Kole M, Fang A. The role of reduced iron powder in the fermentative production of tetanus toxin. Applied Microbiology and Biotechnology. 73: 55-9. PMID 16622677 DOI: 10.1007/S00253-006-0450-2 |
0.711 |
|
| 2006 |
Adrio JL, Demain AL. Genetic improvement of processes yielding microbial products. Fems Microbiology Reviews. 30: 187-214. PMID 16472304 DOI: 10.1111/J.1574-6976.2005.00009.X |
0.344 |
|
| 2006 |
Demain AL. From natural products discovery to commercialization: a success story. Journal of Industrial Microbiology & Biotechnology. 33: 486-95. PMID 16402247 DOI: 10.1007/S10295-005-0076-X |
0.337 |
|
| 2005 |
Demain AL, Gerson DF, Fang A. Effective levels of tetanus toxin can be made in a production medium totally lacking both animal (e.g., brain heart infusion) and dairy proteins or digests (e.g., casein hydrolysates) Vaccine. 23: 5420-5423. PMID 16122852 DOI: 10.1016/J.Vaccine.2005.03.043 |
0.734 |
|
| 2004 |
Demain AL. Pickles, pectin, and penicillin. Annual Review of Microbiology. 58: 1-42. PMID 15487928 DOI: 10.1146/Annurev.Micro.58.030603.123757 |
0.335 |
|
| 2003 |
Demain AL. Herman Jan Phaff: professor, mentor, friend and colleague. International Microbiology : the Official Journal of the Spanish Society For Microbiology. 6: 157-61. PMID 12884058 DOI: 10.1007/S10123-003-0128-X |
0.319 |
|
| 2003 |
Yang W, Kim WS, Fang A, Demain AL. Carbon and nitrogen source nutrition of fumagillin biosynthesis by Aspergillus fumigatus. Current Microbiology. 46: 275-9. PMID 12732977 DOI: 10.1007/S00284-002-3842-2 |
0.322 |
|
| 2003 |
Yang W, Hartwieg EA, Fang A, Demain AL. Effects of carboxymethylcellulose and carboxypolymethylene on morphology of Aspergillus fumigatus NRRL 2346 and fumagillin production. Current Microbiology. 46: 24-7. PMID 12432459 DOI: 10.1007/S00284-002-3711-Z |
0.347 |
|
| 2002 |
Martín JF, Demain AL. Unraveling the methionine-cephalosporin puzzle in Acremonium chrysogenum. Trends in Biotechnology. 20: 502-7. PMID 12443871 DOI: 10.1016/S0167-7799(02)02070-X |
0.331 |
|
| 2002 |
Adrio JL, Demain AL. Improvements in the Formation of Cephalosporins from Penicillin G and Other Penicillins by Bioconversion Organic Process Research & Development. 6: 427-433. DOI: 10.1021/Op020010F |
0.301 |
|
| 2002 |
Sanchez S, Demain AL. Metabolic regulation of fermentation processes Enzyme and Microbial Technology. 31: 895-906. DOI: 10.1016/S0141-0229(02)00172-2 |
0.339 |
|
| 2001 |
Demain AL, Fang A. Secondary metabolism in simulated microgravity Chemical Records. 1: 333-346. PMID 11893073 DOI: 10.1002/Tcr.1018 |
0.369 |
|
| 2001 |
Cheng YR, Huang J, Qiang H, Lin WL, Demain AL. Mutagenesis of the rapamycin producer Streptomyces hygroscopicus FC904. The Journal of Antibiotics. 54: 967-72. PMID 11827040 DOI: 10.7164/Antibiotics.54.967 |
0.325 |
|
| 2001 |
Gao Q, Fang A, Pierson DL, Mishra SK, Demain AL. Shear stress enhances microcin B17 production in a rotating wall bioreactor, but ethanol stress does not. Applied Microbiology and Biotechnology. 56: 384-7. PMID 11549006 DOI: 10.1007/S002530100610 |
0.301 |
|
| 2000 |
Demain AL. Small bugs, big business: the economic power of the microbe. Biotechnology Advances. 18: 499-514. PMID 14538099 DOI: 10.1016/S0734-9750(00)00049-5 |
0.351 |
|
| 2000 |
Demain AL. Edward P. Abraham, cell-free systems and the fungal biosynthesis of beta-lactams. The Journal of Antibiotics. 53: 995-1002. PMID 11132975 DOI: 10.7164/Antibiotics.53.995 |
0.32 |
|
| 2000 |
Demain AL, Fang A. The natural functions of secondary metabolites Advances in Biochemical Engineering/Biotechnology. 69: 1-39. PMID 11036689 DOI: 10.1007/3-540-44964-7_1 |
0.313 |
|
| 2000 |
Kim WS, Wang Y, Fang A, Demain AL. Methionine interference in rapamycin production involves repression of demethylrapamycin methyltransferase and S-adenosylmethionine synthetase Antimicrobial Agents and Chemotherapy. 44: 2908-2910. PMID 10991888 DOI: 10.1128/Aac.44.10.2908-2910.2000 |
0.342 |
|
| 2000 |
Fang A, Pierson DL, Mishra SK, Demain AL. Growth of Steptomyces hygroscopicus in rotating-wall bioreactor under simulated microgravity inhibits rapamycin production. Applied Microbiology and Biotechnology. 54: 33-6. PMID 10952002 DOI: 10.1007/S002539900303 |
0.322 |
|
| 2000 |
Peng Y, Demain AL. Bioconversion of compactin to pravastatin by Actinomadura sp. ATCC 55678 Journal of Molecular Catalysis B: Enzymatic. 10: 151-156. DOI: 10.1016/S1381-1177(00)00123-5 |
0.33 |
|
| 1999 |
Fernández MJ, Adrio JL, Piret JM, Wolfe S, Ro S, Demain AL. Stimulatory effect of growth in the presence of alcohols on biotransformation of penicillin G into cephalosporin-type antibiotics by resting cells of Streptomyces clavuligerus NP1. Applied Microbiology and Biotechnology. 52: 484-8. PMID 10570794 DOI: 10.1007/S002530051549 |
0.315 |
|
| 1999 |
Peng Y, Walker EA, Davis JC, Demain AL. A chemically-defined medium supporting growth and providing cells converting compactin to pravastatin Journal of Industrial Microbiology and Biotechnology. 22: 78-79. DOI: 10.1038/Sj.Jim.2900602 |
0.311 |
|
| 1999 |
Adrio JL, Cho H, Piret JM, Demain AL. Inactivation of deacetoxycephalosporin C synthase in extracts of Streptomyces clavuligerus during bioconversion of penicillin G to deacetoxycephalosporin G Enzyme and Microbial Technology. 25: 497-501. DOI: 10.1016/S0141-0229(99)00084-8 |
0.33 |
|
| 1998 |
Lin WR, Lee CC, Hsu JJ, Hamel JF, Demain AL. Properties of acetate kinase activity in Clostridium thermocellum cell extracts. Applied Biochemistry and Biotechnology. 69: 137-45. PMID 18574732 DOI: 10.1007/Bf02919395 |
0.305 |
|
| 1998 |
Demain AL. Induction of microbial secondary metabolism. International Microbiology : the Official Journal of the Spanish Society For Microbiology. 1: 259-64. PMID 10943372 DOI: 10.2436/Im.V1I4.26 |
0.351 |
|
| 1998 |
Demain AL, Zhang J. Cephalosporin C production by Cephalosporium acremonium: the methionine story. Critical Reviews in Biotechnology. 18: 283-94. PMID 9887506 DOI: 10.1080/0738-859891224176 |
0.346 |
|
| 1998 |
Demain AL. Microbial natural products: alive and well in 1998. Nature Biotechnology. 16: 3-4. PMID 9447575 DOI: 10.1038/Nbt0198-3 |
0.334 |
|
| 1998 |
Kojima I, Demain AL. Preferential production of rapamycin vs prolylrapamycin by Streptomyces hygroscopicus Journal of Industrial Microbiology and Biotechnology. 20: 309-316. DOI: 10.1038/Sj.Jim.2900530 |
0.381 |
|
| 1998 |
Lin WR, Peng Y, Lew S, Lee CC, Hsu JJ, Hamel J, Demain AL. Purification and characterization of acetate kinase from Clostridium thermocellum Tetrahedron. 54: 15915-15925. DOI: 10.1016/S0040-4020(98)01001-1 |
0.302 |
|
| 1997 |
Lee MS, Kojima I, Demain AL. Effect of nitrogen source on biosynthesis of rapamycin by Streptomyces hygroscopicus. Journal of Industrial Microbiology & Biotechnology. 19: 83-6. PMID 9366089 DOI: 10.1038/Sj.Jim.2900434 |
0.357 |
|
| 1997 |
Fang A, Pierson DL, Koenig DW, Mishra SK, Demain AL. Effect of simulated microgravity and shear stress on microcin B17 production by Escherichia coli and on its excretion into the medium. Applied and Environmental Microbiology. 63: 4090-2. PMID 9327574 DOI: 10.1128/Aem.63.10.4090-4092.1997 |
0.305 |
|
| 1997 |
Fang A, Demain AL. Influence of aeration and carbon source on production of microcin B17 by Escherichia coli ZK650 Applied Microbiology and Biotechnology. 47: 547-553. PMID 9210345 DOI: 10.1007/S002530050971 |
0.347 |
|
| 1997 |
Romero J, Martín JF, Liras P, Demain AL, Rius N. Partial purification, characterization and nitrogen regulation of the lysine epsilon-aminotransferase of Streptomyces clavuligerus. Journal of Industrial Microbiology & Biotechnology. 18: 241-6. PMID 9172431 DOI: 10.1038/Sj.Jim.2900370 |
0.375 |
|
| 1997 |
Fang A, Pierson DL, Mishra SK, Koenig DW, Demain AL. Gramicidin S production by Bacillus brevis in simulated microgravity. Current Microbiology. 34: 199-204. PMID 9058537 DOI: 10.1007/S002849900168 |
0.304 |
|
| 1997 |
Rius N, Demain AL. Regulation of lysine ε-aminotransferase by carbon source and lack of control by phosphate in Streptomyces clavuligerus Applied Microbiology and Biotechnology. 48: 735-737. DOI: 10.1007/S002530051125 |
0.382 |
|
| 1996 |
Rius N, Maeda K, Demain AL. Induction of L-lysine epsilon-aminotransferase by L-lysine in Streptomyces clavuligerus, producer of cephalosporins. Fems Microbiology Letters. 144: 207-11. PMID 8900065 DOI: 10.1111/J.1574-6968.1996.Tb08532.X |
0.354 |
|
| 1996 |
Fang A, Keables P, Demain AL. Unexpected enhancement of β-lactam antibiotic formation in Streptomyces clavuligerus by very high concentrations of exogenous lysine Applied Microbiology and Biotechnology. 44: 705-709. PMID 8867627 DOI: 10.1007/Bf00178606 |
0.346 |
|
| 1995 |
Fang A, Demain AL. Exogenous shikimic acid stimulates rapamycin biosynthesis in Streptomyces hygroscopicus Folia Microbiologica. 40: 607-610. PMID 8768251 DOI: 10.1007/Bf02818516 |
0.337 |
|
| 1995 |
Cheng YR, Fang A, Demain AL. Effect of amino acids on rapamycin biosynthesis by Streptomyces hygroscopicus. Applied Microbiology and Biotechnology. 43: 1096-8. PMID 8590661 DOI: 10.1007/Bf00166931 |
0.369 |
|
| 1995 |
Fang A, Demain AL. Dependence of nitrogen- and phosphorus-regulation of β-lactam antibiotic production by Streptomyces clavuligerus on aeration level Journal of Industrial Microbiology. 15: 407-410. PMID 8588881 DOI: 10.1007/Bf01569965 |
0.321 |
|
| 1995 |
Kojima I, Cheng YR, Mohan V, Demain AL. Carbon source nutrition of rapamycin biosynthesis in Streptomyces hygroscopicus. Journal of Industrial Microbiology. 14: 436-9. PMID 7662284 DOI: 10.1007/Bf01573954 |
0.323 |
|
| 1995 |
Cheng YR, Hauck L, Demain AL. Phosphate, ammonium, magnesium and iron nutrition of Streptomyces hygroscopicus with respect to rapamycin biosynthesis. Journal of Industrial Microbiology. 14: 424-7. PMID 7612217 DOI: 10.1007/Bf01569962 |
0.333 |
|
| 1994 |
Kasarenini S, Demain AL. A role for alanine in the ammonium regulation of cephalosporin biosynthesis in Streptomyces clavuligerus. Journal of Industrial Microbiology. 13: 217-9. PMID 7765047 DOI: 10.1007/Bf01569751 |
0.37 |
|
| 1994 |
Adler-Nissen J, Demain AL. Aeration-controlled formation of acetic acid in heterolactic fermentations Journal of Industrial Microbiology. 13: 335-343. DOI: 10.1007/Bf01577216 |
0.315 |
|
| 1994 |
Lin TF, Demain AL. Leucine interference in the production of water-soluble red Monascus pigments Archives of Microbiology. 162: 114-119. DOI: 10.1007/Bf00264383 |
0.35 |
|
| 1993 |
Romaniec MP, Huskisson N, Barker P, Demain AL. Purification and properties of the Clostridium thermocellum bglB gene product expressed in Escherichia coli. Enzyme and Microbial Technology. 15: 393-400. PMID 7763628 DOI: 10.1016/0141-0229(93)90125-L |
0.308 |
|
| 1993 |
Paiva NL, Demain AL, Roberts MF. The immediate precursor of the nitrogen-containing ring of rapamycin is free pipecolic acid Enzyme and Microbial Technology. 15: 581-585. DOI: 10.1016/0141-0229(93)90020-3 |
0.307 |
|
| 1993 |
Paiva NL, Roberts MF, Demain AL. The cyclohexane moiety of rapamycin is derived from shikimic acid in Streptomyces hygroscopicus Journal of Industrial Microbiology. 12: 423-428. DOI: 10.1007/Bf01569676 |
0.321 |
|
| 1993 |
Lin TF, Demain AL. Resting cell studies on formation of water-soluble red pigments byMonascus sp. Journal of Industrial Microbiology. 12: 361-367. DOI: 10.1007/Bf01569666 |
0.368 |
|
| 1993 |
Nochur SV, Roberts MF, Demain AL. True cellulase production by Clostridium thermocellum grown on different carbon sources Biotechnology Letters. 15: 641-646. DOI: 10.1007/Bf00138556 |
0.34 |
|
| 1992 |
Romaniec MP, Fauth U, Kobayashi T, Huskisson NS, Barker PJ, Demain AL. Purification and characterization of a new endoglucanase from Clostridium thermocellum. The Biochemical Journal. 283: 69-73. PMID 1567379 DOI: 10.1042/Bj2830069 |
0.321 |
|
| 1992 |
Zhang J, Demain AL. In vitro stabilization of acv synthetase activity fromStreptomyces clavuligerus Applied Biochemistry and Biotechnology. 37: 97-110. DOI: 10.1007/Bf02921663 |
0.318 |
|
| 1992 |
Zhang J, Demain AL. Regulation of ACV synthetase activity in the beta-lactam biosynthetic pathway by carbon sources and their metabolites Archives of Microbiology. 158: 364-369. DOI: 10.1007/Bf00245366 |
0.317 |
|
| 1991 |
Shoham Y, Demain AL. Kinetics of loss of a recombinant plasmid in Bacillus subtilis. Biotechnology and Bioengineering. 37: 927-35. PMID 18597317 DOI: 10.1002/Bit.260371006 |
0.301 |
|
| 1991 |
Zhang J, Demain AL. Regulation of ACV synthetase in penicillin- and cephalosporin-producing microorganisms. Biotechnology Advances. 9: 623-41. PMID 14542052 DOI: 10.1016/0734-9750(91)90735-E |
0.355 |
|
| 1991 |
Shoham Y, Israeli E, Sonensheim AL, Demain AL. Inhibition of growth of Bacillus subtilis by recombinant plasmid pCED3. Archives of Microbiology. 156: 204-12. PMID 1953304 DOI: 10.1007/Bf00249116 |
0.306 |
|
| 1991 |
Fauth U, Romaniec MP, Kobayashi T, Demain AL. Purification and characterization of endoglucanase Ss from Clostridium thermocellum. The Biochemical Journal. 279: 67-73. PMID 1930156 DOI: 10.1042/Bj2790067 |
0.3 |
|
| 1991 |
Shoham Y, Stephanopoulos G, Demain AL. Effects of the β-lactamase gene and orientation of the kanamycin-resistance gene in plasmid pCED3 on the growth of Bacillus subtilis Journal of Fermentation and Bioengineering. 72: 244-248. DOI: 10.1016/0922-338X(91)90156-B |
0.301 |
|
| 1991 |
Lin TF, Demain AL. Effect of nutrition of Monascus sp. on formation of red pigments Applied Microbiology and Biotechnology. 36: 70-75. DOI: 10.1007/Bf00164701 |
0.351 |
|
| 1990 |
Zhang JY, Demain AL. Purification from Cephalosporium acremonium of the initial enzyme unique to the biosynthesis of penicillins and cephalosporins. Biochemical and Biophysical Research Communications. 169: 1145-52. PMID 2363718 DOI: 10.1016/0006-291X(90)92015-R |
0.308 |
|
| 1990 |
Williams GB, Weaver JC, Demain AL. Rapid microbial detection and enumeration using gel microdroplets and colorimetric or fluorescence indicator systems. Journal of Clinical Microbiology. 28: 1002-8. PMID 2191001 DOI: 10.1128/Jcm.28.5.1002-1008.1990 |
0.301 |
|
| 1990 |
Ozcengiz G, Alaeddinoglu NG, Demain AL. Regulation of biosynthesis of bacilysin by Bacillus subtilis. Journal of Industrial Microbiology. 6: 91-100. PMID 1367485 DOI: 10.1007/Bf01576428 |
0.39 |
|
| 1990 |
Shoham Y, Demain AL. Effect of medium composition on the maintenance of a recombinant plasmid in Bacillus subtilis. Enzyme and Microbial Technology. 12: 330-6. PMID 1367440 DOI: 10.1016/0141-0229(90)90160-R |
0.316 |
|
| 1990 |
Piret J, Resendiz B, Mahro B, Zhang JY, Serpe E, Romero J, Connors N, Demain AL. Characterization and complementation of a cephalosporin-deficient mutant of Streptomyces clavuligerus NRRL 3585. Applied Microbiology and Biotechnology. 32: 560-7. PMID 1366440 DOI: 10.1007/Bf00173728 |
0.321 |
|
| 1990 |
Shoham Y, Demain AL. Stabilization of a plasmid-encoded LacZ phenotype inBacillus subtilis Current Microbiology. 20: 373-379. DOI: 10.1007/Bf02095863 |
0.307 |
|
| 1989 |
Jhang J, Wolfe S, Demain AL. Phosphate regulation of ACV synthetase and cephalosporin biosynthesis in Streptomyces clavuligerus. Fems Microbiology Letters. 48: 145-50. PMID 2721913 DOI: 10.1111/J.1574-6968.1989.Tb03289.X |
0.308 |
|
| 1989 |
Zhang J, Wolfe S, Demain AL. Ammonium ions repress δ-(L-α-aminoadipyl)-L-cysteinyl-D-valine synthetase in Streptomyces clavuligerus NRRL 3585 Canadian Journal of Microbiology. 35: 399-402. DOI: 10.1139/M89-061 |
0.333 |
|
| 1989 |
Zhang J, Wolfe S, Demain AL. Carbon source regulation of ACV synthetase inCephalosporium acremonium C-10 Current Microbiology. 18: 361-367. DOI: 10.1007/Bf01571129 |
0.321 |
|
| 1988 |
Weaver JC, Williams GB, Klibanov A, Demain AL. Gil microdroplets: Rapid detection and enumeration of individual microorganisms by their metabolic activity Bio/Technology. 6: 1084-1089. DOI: 10.1038/Nbt0988-1084 |
0.306 |
|
| 1988 |
Zhang J, Wolfe S, Demain AL. Phosphate repressible and inhibitable β-lactam synthetases inCephalosporium acremonium strain C-10 Applied Microbiology and Biotechnology. 29: 242-247. DOI: 10.1007/Bf01982910 |
0.336 |
|
| 1987 |
Zhang JY, Wolfe S, Demain AL. Effect of ammonium as nitrogen source on production of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase by Cephalosporium acremonium C-10. The Journal of Antibiotics. 40: 1746-50. PMID 3429339 DOI: 10.7164/Antibiotics.40.1746 |
0.333 |
|
| 1987 |
Zhang J, Banko G, Wolfe S, Demain AL. Methionine induction of ACV synthetase inCephalosporium acremonium Journal of Industrial Microbiology. 2: 251-255. DOI: 10.1007/Bf01569547 |
0.362 |
|
| 1987 |
Sakajoh M, Solomon NA, Demain AL. Cell-free synthesis of the dipeptide antibiotic bacilysin Journal of Industrial Microbiology. 2: 201-208. DOI: 10.1007/Bf01569541 |
0.327 |
|
| 1987 |
Uyeda M, Demain AL. Deacetylation ofN-acetylthienamycin to thienamycin by a cell-free extract ofStreptomyces cattleya, the thienamycin producer Journal of Industrial Microbiology. 1: 341-347. DOI: 10.1007/Bf01569330 |
0.308 |
|
| 1986 |
Braña AF, Wolfe S, Demain AL. Ammonium repression of cephalosporin production by Streptomyces clavuligerus. Canadian Journal of Microbiology. 31: 736-43. PMID 3841023 DOI: 10.1139/M85-138 |
0.393 |
|
| 1986 |
Brana AF, Wolfe S, Demain AL. Relationship between nitrogen assimilation and cephalosporin synthesis in Streptomyces clavuligerus. Archives of Microbiology. 146: 46-51. PMID 2880574 DOI: 10.1007/Bf00690157 |
0.357 |
|
| 1986 |
Demain AL, Agathos SN. Studies on in vivo inactivation of gramicidin S synthetase and its retardation. Canadian Journal of Microbiology. 32: 208-14. PMID 2423219 DOI: 10.1139/M86-042 |
0.587 |
|
| 1986 |
BRANA AF, PAIVA N, DEMAIN AL. Pathways and Regulation of Ammonium Assimilation in Streptomyces clavuligerus Microbiology. 132: 1305-1317. DOI: 10.1099/00221287-132-5-1305 |
0.315 |
|
| 1986 |
Venkateswaran S, Demain AL. The Clostridium Thermocellum-Clostridium Thermosaccharolyticum Ethanol Production Process: Nutritional Studies And Scale-Down Chemical Engineering Communications. 45: 53-60. DOI: 10.1080/00986448608911371 |
0.348 |
|
| 1986 |
Agathos SN, Demain AL. Substrate amino acid-mediated stabilization of gramicidin S synthetase activity against inactivation in vivo Enzyme and Microbial Technology. 8: 465-468. DOI: 10.1016/0141-0229(86)90048-7 |
0.309 |
|
| 1986 |
Agathos S, Demain A. Dissolved oxygen levels and the in vivo stability of gramicidin S synthetase Applied Microbiology and Biotechnology. 24. DOI: 10.1007/Bf00257056 |
0.534 |
|
| 1985 |
Lübbe C, Wolfe S, Demain AL. Repression and inhibition of cephalosporin synthetases in Streptomyces clavuligerus by inorganic phosphate. Archives of Microbiology. 140: 317-20. PMID 3985747 DOI: 10.1007/Bf00446970 |
0.359 |
|
| 1985 |
JOHNSON EA, BOUCHOT F, DEMAIN AL. Regulation of Cellulase Formation in Clostridium thermocellum Microbiology. 131: 2303-2308. DOI: 10.1099/00221287-131-9-2303 |
0.325 |
|
| 1985 |
L�bbe C, Demain A, Bergman K. Use of controlled-release polymer to feed ammonium to Streptomyces clavuligerus cephalosporin fermentations in shake flasks Applied Microbiology and Biotechnology. 22. DOI: 10.1007/Bf00257044 |
0.302 |
|
| 1984 |
Fa YH, Kusel JP, Demain AL. Dependence of betaine stimulation of vitamin b(12) overproduction on protein synthesis. Applied and Environmental Microbiology. 47: 1067-9. PMID 16346536 DOI: 10.1128/Aem.47.5.1067-1069.1984 |
0.31 |
|
| 1984 |
Agathos SN, Demain AL. Gramicidin S synthetase stabilization in vivo. Annals of the New York Academy of Sciences. 434: 44-7. PMID 6596901 DOI: 10.1111/J.1749-6632.1984.Tb29798.X |
0.511 |
|
| 1984 |
Hollander IJ, Shen YQ, Heim J, Demain AL, Wolfe S. A pure enzyme catalyzing penicillin biosynthesis. Science (New York, N.Y.). 224: 610-2. PMID 6546810 DOI: 10.1126/Science.6546810 |
0.301 |
|
| 1984 |
Lübbe C, Jensen SE, Demain AL. Prevention of phosphate inhibition of cephalosporin synthetases by ferrous ion Fems Microbiology Letters. 25: 75-79. DOI: 10.1111/J.1574-6968.1984.Tb01379.X |
0.325 |
|
| 1984 |
David Wu JH, Yang L, Demain AL. Further studies on the role of phenylalanine in gramicidin S biosynthesis by Bacillus brevis Journal of Biotechnology. 1: 81-94. DOI: 10.1016/0168-1656(84)90011-7 |
0.376 |
|
| 1984 |
Hu W, Braña AF, Demain AL. Carbon source regulation of cephem antibiotic production by resting cells of Streptomyces clavuligerus and its reversal by protein synthesis inhibitors Enzyme and Microbial Technology. 6: 155-160. DOI: 10.1016/0141-0229(84)90023-1 |
0.35 |
|
| 1984 |
Heim J, Shen Y, Wolfe S, Demain AL. Regulation of isopenicillin N synthetase and deacetoxycephalosporin C synthetase by carbon source during the fermentation of Cephalosporium acremonium Applied Microbiology and Biotechnology. 19: 232-236. DOI: 10.1007/Bf00251842 |
0.346 |
|
| 1983 |
Kachholz T, Demain AL. Nitrate Repression of Averufin and Aflatoxin Biosynthesis Journal of Natural Products. 46: 499-506. DOI: 10.1021/Np50028A013 |
0.302 |
|
| 1983 |
Behmer CJ, Demain AL. Further studies on carbon catabolite regulation of β-lactam antibiotic synthesis inCephalosporium acremonium Current Microbiology. 8: 107-114. DOI: 10.1007/Bf01566967 |
0.383 |
|
| 1983 |
Brana AF, Hu WS, Demain AL. Involvement of aeration in carbon source regulation of Cephem antibiotic biosynthesis in Streptomyces clavuligerus Biotechnology Letters. 5: 791-794. DOI: 10.1007/Bf01386649 |
0.319 |
|
| 1982 |
Longin R, Cooney CL, Demain AL. Studies on the overproduction of indole-containing metabolites by a methanol-utilizing yeast : Hansenula polymorpha. Applied Biochemistry and Biotechnology. 7: 281-93. PMID 24234284 DOI: 10.1007/Bf02798306 |
0.403 |
|
| 1982 |
Johnson EA, Sakajoh M, Halliwell G, Madia A, Demain AL. Saccharification of Complex Cellulosic Substrates by the Cellulase System from Clostridium thermocellum. Applied and Environmental Microbiology. 43: 1125-32. PMID 16346009 DOI: 10.1128/Aem.43.5.1125-1132.1982 |
0.307 |
|
| 1981 |
Denenu EO, Demain AL. Enzymatic Basis for Overproduction of Tryptophan and Its Metabolites in Hansenula polymorpha Mutants. Applied and Environmental Microbiology. 42: 497-501. PMID 16345845 DOI: 10.1128/Aem.42.3.497-501.1981 |
0.337 |
|
| 1981 |
Denenu EO, Demain AL. Derivation of Aromatic Amino Acid Mutants from a Methanol-Utilizing Yeast, Hansenula polymorpha. Applied and Environmental Microbiology. 41: 1088-96. PMID 16345763 DOI: 10.1128/Aem.41.5.1088-1096.1981 |
0.311 |
|
| 1981 |
Demain AL. Microbial production of primary metabolites. Die Naturwissenschaften. 67: 582-7. PMID 7231563 DOI: 10.1007/Bf00396537 |
0.354 |
|
| 1981 |
Werner RG, Demain AL. Directed biosynthesis of new indolmycins. The Journal of Antibiotics. 34: 551-4. PMID 6792175 DOI: 10.7164/Antibiotics.34.551 |
0.313 |
|
| 1981 |
Kennel Y, Behmer C, Demain A. Differential effect of cycloheximide on penicillin and cephalosporin biosynthesis by Cephalosporium acremonium Enzyme and Microbial Technology. 3: 243-245. DOI: 10.1016/0141-0229(81)90093-4 |
0.351 |
|
| 1980 |
Sawada Y, Baldwin JE, Singh PD, Solomon NA, Demain AL. Cell-free cyclization of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine to isopenicillin N. Antimicrobial Agents and Chemotherapy. 18: 465-70. PMID 7191691 DOI: 10.1128/Aac.18.3.465 |
0.314 |
|
| 1980 |
Demain AL. The astonishing synthetic versatility of microorganisms Biotechnology Letters. 2: 171-176. DOI: 10.1007/Bf00162940 |
0.341 |
|
| 1979 |
Souw P, Demain AL. Nutritional Studies on Xanthan Production by Xanthomonas campestris NRRL B1459. Applied and Environmental Microbiology. 37: 1186-92. PMID 16345398 DOI: 10.1128/Aem.37.6.1186-1192.1979 |
0.393 |
|
| 1979 |
Konomi T, Herchen S, Baldwin JE, Yoshida M, Hunt NA, Demain AL. Cell-free conversion of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine into an antibiotic with the properties of isopenicillin N in Cephalosporium acremonium. The Biochemical Journal. 184: 427-30. PMID 575041 DOI: 10.1042/Bj1840427 |
0.324 |
|
| 1979 |
Aharonowitz Y, Demain AL. Nitrogen nutrition and regulation of cephalosporin production in Streptomyces clavuligerus. Canadian Journal of Microbiology. 25: 61-7. PMID 427656 DOI: 10.1139/M79-010 |
0.394 |
|
| 1978 |
Aharonowitz Y, Demain AL. Carbon catabolite regulation of cephalosporin production in Streptomyces clavuligerus. Antimicrobial Agents and Chemotherapy. 14: 159-64. PMID 697343 DOI: 10.1128/Aac.14.2.159 |
0.348 |
|
| 1978 |
Sanchez S, Demain AL. Tryptophan excretion by a bradytroph of Hansenula polymorpha growing in methanol. Applied and Environmental Microbiology. 35: 459-61. PMID 637543 DOI: 10.1128/Aem.35.2.459-461.1978 |
0.327 |
|
| 1978 |
Friedrich CG, Demain AL. Homocitrate synthase as the crucial site of the lysine effect on penicillin biosynthesis. The Journal of Antibiotics. 30: 760-1. PMID 411778 DOI: 10.7164/Antibiotics.30.760 |
0.305 |
|
| 1978 |
Martin JF, Demain AL. Effect of exogenous nucleotides on the candicidin fermentation. Canadian Journal of Microbiology. 23: 1334-9. PMID 200324 DOI: 10.1139/M77-202 |
0.33 |
|
| 1978 |
Aharonowitz Y, Demain AL. Influence of inorganic phosphate and organic buffers on cephalosporin production by Streptomyces clavuligerus. Archives of Microbiology. 115: 169-73. PMID 23086 DOI: 10.1007/Bf00406371 |
0.356 |
|
| 1978 |
Kennel YM, Demain AL. Effect of carbon sources on β-lactam antibiotic formation by Cephalosporium acremonium Experimental Mycology. 2: 234-238. DOI: 10.1016/S0147-5975(78)80016-4 |
0.334 |
|
| 1977 |
Kobbe B, Cushman M, Wogan GN, Demain AL. Production and antibacterial activity of malformin C, a toxic metabolite of Aspergillus niger Applied and Environmental Microbiology. 33: 996-997. PMID 869543 DOI: 10.1128/Aem.33.4.996-997.1977 |
0.333 |
|
| 1976 |
Drew SW, Demain AL. Stimulation of cephalosporin production by methionine peptides in a mutant blocked in reverse transsulfuration. The Journal of Antibiotics. 28: 889-95. PMID 1238384 DOI: 10.7164/Antibiotics.28.889 |
0.326 |
|
| 1976 |
Kohsaka M, Demain AL. Conversion of penicillin N to cephalosporin(s) by cell-free extracts of Cephalosporium acremonium. Biochemical and Biophysical Research Communications. 70: 465-73. PMID 945737 DOI: 10.1016/0006-291X(76)91069-X |
0.389 |
|
| 1976 |
Demain AL, Hunt NA, Malik V, Kobbe B, Hawkins H, Matsuo K, Wogan GN. Improved procedure for production of cytochalasin E and tremorgenic mycotoxins by Aspergillus clavatus Applied and Environmental Microbiology. 31: 138-140. PMID 942203 DOI: 10.1128/Aem.31.1.138-140.1976 |
0.303 |
|
| 1976 |
Martin JF, Demain AL. Control by phosphate of candicidin production. Biochemical and Biophysical Research Communications. 71: 1103-9. PMID 823941 DOI: 10.1016/0006-291X(76)90767-1 |
0.342 |
|
| 1976 |
Matteo CC, Cooney CL, Demain AL. Production of gramicidin S synthetases by Bacillus brevis in continuous culture. Journal of General Microbiology. 96: 415-22. PMID 62820 DOI: 10.1099/00221287-96-2-415 |
0.337 |
|
| 1976 |
Demain AL, Matteo CC. Phenylalanine stimulation of gramicidin S formation. Antimicrobial Agents and Chemotherapy. 9: 1000-3. PMID 59576 DOI: 10.1128/Aac.9.6.1000 |
0.327 |
|
| 1975 |
Drew SW, Demain AL. Production of cephalosporin C by single and double sulfur auxotrophic mutants of Cephalosporium acremonium. Antimicrobial Agents and Chemotherapy. 8: 5-10. PMID 1172409 DOI: 10.1128/Aac.8.1.5 |
0.371 |
|
| 1975 |
Nagaoka K, Demain AL. Mutational biosynthesis of a new antibiotic, streptomutin A, by an idiotroph of Streptomyces griseus. The Journal of Antibiotics. 28: 627-35. PMID 241738 DOI: 10.7164/Antibiotics.28.627 |
0.332 |
|
| 1975 |
Inamine E, Demain AL. Mannosidostreptomycin hydrolase. Methods in Enzymology. 43: 637-40. PMID 237218 DOI: 10.1016/0076-6879(75)43128-7 |
0.302 |
|
| 1975 |
Matteo CC, Glade M, Tanaka A, Piret J, Demain AL. Microbiological studies on the formation of gramicidin S synthetases Biotechnology and Bioengineering. 17: 129-142. DOI: 10.1002/Bit.260170111 |
0.377 |
|
| 1974 |
Bok SH, Demain AL. Growth of microorganisms on chemically synthesized carbohydrate ("formose") syrups. Biotechnology and Bioengineering. 16: 209-30. PMID 4593696 DOI: 10.1002/Bit.260160205 |
0.318 |
|
| 1973 |
Drew SW, Demain AL. Methionine control of cephalosporin C formation. Biotechnology and Bioengineering. 15: 743-54. PMID 4738311 DOI: 10.1002/Bit.260150408 |
0.355 |
|
| 1973 |
Demain AL. Mutation and the production of secondary metabolites. Advances in Applied Microbiology. 16: 177-202. PMID 4584678 DOI: 10.1016/S0065-2164(08)70027-3 |
0.342 |
|
| 1971 |
Demain AL. [12] Increasing enzyme production by genetic and environmental manipulations Methods in Enzymology. 22: 86-95. DOI: 10.1016/0076-6879(71)22014-0 |
0.339 |
|
| 1956 |
PHAFF HJ, DEMAIN AL. The unienzymatic nature of yeast polygalacturonase. The Journal of Biological Chemistry. 218: 875-84. PMID 13295238 |
0.512 |
|
| 1954 |
DEMAIN AL, PHAFF HJ. Hydrolysis of the oligogalacturonides and pectic acid by yeast polygalacturonase. The Journal of Biological Chemistry. 210: 381-93. PMID 13201600 |
0.517 |
|
| 1954 |
DEMAIN AL, PHAFF HJ. Composition and action of yeast polygalacturonase. Nature. 174: 515. PMID 13194026 DOI: 10.1038/174515A0 |
0.524 |
|
| 1954 |
SHIFRINE M, PHAFF HJ, DEMAIN AL. Determination of carbon assimilation patterns of yeasts by replica plating. Journal of Bacteriology. 68: 28-35. PMID 13183894 DOI: 10.1128/Jb.68.1.28-35.1954 |
0.527 |
|
| 1954 |
DEMAIN AL, PHAFF HJ. The preparation of tetragalacturonic acid. Archives of Biochemistry and Biophysics. 51: 114-21. PMID 13181466 DOI: 10.1016/0003-9861(54)90459-2 |
0.514 |
|
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