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Eric M. Brustad - Publications

Affiliations: 
Chemistry University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
Biocatalysis, Chemical Biology, Protein Engineering, Directed Evolution, Unnatural Amino Acid Mutagenesis, X-ray crystallography
Website:
http://www.chem.unc.edu/people/faculty/brustad/index.html
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38 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Kean KM, Baril SA, Lamb KN, Dishman SN, Treacy JW, Houk KN, Brustad EM, James LI, Waters ML. Systematic Variation of Both the Aromatic Cage and Dialkyllysine via GCE-SAR Reveal Mechanistic Insights in CBX5 Reader Protein Binding. Journal of Medicinal Chemistry. PMID 35014255 DOI: 10.1021/acs.jmedchem.1c02049  0.791
2020 Krone MW, Albanese KI, Leighton GO, He CQ, Lee GY, Garcia-Borràs M, Guseman AJ, Williams DC, Houk KN, Brustad EM, Waters ML. Thermodynamic consequences of Tyr to Trp mutations in the cation-π-mediated binding of trimethyllysine by the HP1 chromodomain. Chemical Science. 11: 3495-3500. PMID 34109021 DOI: 10.1039/d0sc00227e  0.797
2020 Schwochert TD, Cruz C, Watters JW, Reynolds EW, Nicewicz DA, Brustad E. Design and Evaluation of Artificial Hybrid Photoredox Biocatalysts. Chembiochem : a European Journal of Chemical Biology. PMID 32529779 DOI: 10.1002/Cbic.202000362  0.778
2020 Krone MW, Albanese KI, Leighton GO, He CQ, Lee GY, Garcia-Borràs M, Guseman AJ, Williams DC, Houk KN, Brustad EM, Waters ML. Thermodynamic consequences of Tyr to Trp mutations in the cation–π-mediated binding of trimethyllysine by the HP1 chromodomain Chemical Science. 11: 3495-3500. DOI: 10.1039/D0Sc00227E  0.805
2019 Albanese KI, Krone MW, Petell CJ, Parker MM, Strahl BD, Brustad EM, Waters ML. Engineered Reader Proteins for Enhanced Detection of Methylated Lysine on Histones. Acs Chemical Biology. PMID 31634430 DOI: 10.1021/Acschembio.9B00651  0.757
2018 Costa S, Mozhdehi D, Dzuricky M, Isaacs FJ, Brustad E, Chilkoti A. Active Targeting of Cancer Cells by Nanobody Decorated Polypeptide Micelle with Bioorthogonally Conjugated Drug. Nano Letters. PMID 30540482 DOI: 10.1021/Acs.Nanolett.8B03837  0.308
2018 Rydeen AE, Brustad EM, Pielak GJ. Osmolytes and protein-protein interactions. Journal of the American Chemical Society. PMID 29842777 DOI: 10.1021/Jacs.8B03903  0.776
2018 Gober JG, Rydeen AE, Schwochert TD, Gibson-O'Grady EJ, Brustad EM. Enhancing cytochrome P450-mediated non-natural cyclopropanation by mutation of a conserved second-shell residue. Biotechnology and Bioengineering. PMID 29460311 DOI: 10.1002/Bit.26571  0.757
2017 Baril SA, Koenig AL, Krone MW, Albanese KI, He QC, Lee GY, Houk KN, Waters ML, Brustad EM. Investigation of Trimethyllysine Binding by the HP1 Chro-modomain via Unnatural Amino Acid Mutagenesis. Journal of the American Chemical Society. PMID 29111699 DOI: 10.1021/Jacs.7B09223  0.764
2017 Brustad E, Reynolds EW, Schwochert TD, McHenry MW, Watters JW. Orthogonal expression of an artificial metalloenzyme for abiotic catalysis. Chembiochem : a European Journal of Chemical Biology. PMID 29024391 DOI: 10.1002/Cbic.201700397  0.801
2017 Gober JG, Ghodge SV, Bogart JW, Wever WJ, Watkins RR, Brustad EM, Bowers AA. P450-Mediated Non-natural Cyclopropanation of Dehydro-alanine-containing Thiopeptides. Acs Chemical Biology. PMID 28535034 DOI: 10.1021/Acschembio.7B00358  0.796
2016 Gober JG, Rydeen AE, Gibson-O'Grady EJ, Leuthaeuser JB, Fetrow JS, Brustad EM. Corrigendum: Mutating a Highly Conserved Residue in Diverse Cytochrome P450s Facilitates Diastereoselective Olefin Cyclopropanation. Chembiochem : a European Journal of Chemical Biology. 17: 2099. PMID 27805325 DOI: 10.1002/cbic.201600528  0.778
2016 Reynolds EW, McHenry MW, Cannac F, Gober JG, Snow CD, Brustad EM. Correction to "An Evolved Orthogonal Enzyme/Cofactor Pair". Journal of the American Chemical Society. PMID 27759385 DOI: 10.1021/Jacs.6B10459  0.763
2016 Gober JG, Brustad EM. Non-natural carbenoid and nitrenoid insertion reactions catalyzed by heme proteins. Current Opinion in Chemical Biology. 35: 124-132. PMID 27697701 DOI: 10.1016/J.Cbpa.2016.09.004  0.792
2016 Reynolds EW, McHenry MW, Cannac F, Gober JG, Snow CD, Brustad EM. An evolved orthogonal enzyme/cofactor pair. Journal of the American Chemical Society. PMID 27575374 DOI: 10.1021/Jacs.6B05847  0.794
2015 Gober JG, Rydeen AE, Gibson-O'Grady EJ, Leuthaeuser JB, Fetrow JS, Brustad EM. Mutating a Highly Conserved Residue in Diverse Cytochrome P450s Facilitates Diastereoselective Olefin Cyclopropanation. Chembiochem : a European Journal of Chemical Biology. PMID 26690878 DOI: 10.1002/Cbic.201500624  0.788
2014 Snyder AL, Brustad EM. Tissue-specific proteome tagging: an orthogonal approach. Chembiochem : a European Journal of Chemical Biology. 15: 1731-3. PMID 24990619 DOI: 10.1002/Cbic.201402210  0.734
2014 Coelho PS, Wang ZJ, Ener ME, Baril SA, Kannan A, Arnold FH, Brustad EM. Erratum: Corrigendum: A serine-substituted P450 catalyzes highly efficient carbene transfer to olefins in vivo Nature Chemical Biology. 10: 164-164. DOI: 10.1038/Nchembio0214-164D  0.778
2013 Coelho PS, Wang ZJ, Ener ME, Baril SA, Kannan A, Arnold FH, Brustad EM. A serine-substituted P450 catalyzes highly efficient carbene transfer to olefins in vivo. Nature Chemical Biology. 9: 485-7. PMID 23792734 DOI: 10.1038/Nchembio.1278  0.791
2013 Brinkmann-Chen S, Flock T, Cahn JK, Snow CD, Brustad EM, McIntosh JA, Meinhold P, Zhang L, Arnold FH. General approach to reversing ketol-acid reductoisomerase cofactor dependence from NADPH to NADH. Proceedings of the National Academy of Sciences of the United States of America. 110: 10946-51. PMID 23776225 DOI: 10.1073/Pnas.1306073110  0.762
2013 Coelho PS, Brustad EM, Kannan A, Arnold FH. Olefin cyclopropanation via carbene transfer catalyzed by engineered cytochrome P450 enzymes. Science (New York, N.Y.). 339: 307-10. PMID 23258409 DOI: 10.1126/Science.1231434  0.538
2013 Smith MA, Romero PA, Wu T, Brustad EM, Arnold FH. Chimeragenesis of distantly-related proteins by noncontiguous recombination. Protein Science : a Publication of the Protein Society. 22: 231-8. PMID 23225662 DOI: 10.1002/Pro.2202  0.691
2012 Liu X, Bastian S, Snow CD, Brustad EM, Saleski TE, Xu JH, Meinhold P, Arnold FH. Structure-guided engineering of Lactococcus lactis alcohol dehydrogenase LlAdhA for improved conversion of isobutyraldehyde to isobutanol. Journal of Biotechnology. 164: 188-95. PMID 22974724 DOI: 10.1016/J.Jbiotec.2012.08.008  0.754
2012 Brustad EM, Lelyveld VS, Snow CD, Crook N, Jung ST, Martinez FM, Scholl TJ, Jasanoff A, Arnold FH. Structure-guided directed evolution of highly selective p450-based magnetic resonance imaging sensors for dopamine and serotonin. Journal of Molecular Biology. 422: 245-62. PMID 22659321 DOI: 10.1016/J.Jmb.2012.05.029  0.743
2011 Charbon G, Wang J, Brustad E, Schultz PG, Horwich AL, Jacobs-Wagner C, Chapman E. Localization of GroEL determined by in vivo incorporation of a fluorescent amino acid. Bioorganic & Medicinal Chemistry Letters. 21: 6067-70. PMID 21890355 DOI: 10.1016/J.Bmcl.2011.08.057  0.781
2011 Charbon G, Brustad E, Scott KA, Wang J, Løbner-Olesen A, Schultz PG, Jacobs-Wagner C, Chapman E. Subcellular protein localization by using a genetically encoded fluorescent amino acid. Chembiochem : a European Journal of Chemical Biology. 12: 1818-21. PMID 21681882 DOI: 10.1002/Cbic.201100282  0.785
2011 Brustad EM, Arnold FH. Optimizing non-natural protein function with directed evolution. Current Opinion in Chemical Biology. 15: 201-10. PMID 21185770 DOI: 10.1016/J.Cbpa.2010.11.020  0.584
2011 Lelyveld VS, Brustad E, Arnold FH, Jasanoff A. Metal-substituted protein MRI contrast agents engineered for enhanced relaxivity and ligand sensitivity. Journal of the American Chemical Society. 133: 649-51. PMID 21171606 DOI: 10.1021/Ja107936D  0.558
2010 Ai HW, Shen W, Brustad E, Schultz PG. Genetically encoded alkenes in yeast. Angewandte Chemie (International Ed. in English). 49: 935-7. PMID 20025009 DOI: 10.1002/Anie.200905590  0.706
2010 Fleissner MR, Brustad EM, Kálai T, Altenbach C, Cascio D, Peters FB, Hideg K, Peuker S, Schultz PG, Hubbell WL. Site-directed spin labeling of a genetically encoded unnatural amino acid (Proceedings of the National Academy of Sciences of the United States of America (2009) 106, 51 (21637-21642)) Proceedings of the National Academy of Sciences of the United States of America. 107: 5693. DOI: 10.1073/Pnas.1000908107  0.465
2009 Fleissner MR, Brustad EM, Kálai T, Altenbach C, Cascio D, Peters FB, Hideg K, Peuker S, Schultz PG, Hubbell WL. Site-directed spin labeling of a genetically encoded unnatural amino acid. Proceedings of the National Academy of Sciences of the United States of America. 106: 21637-42. PMID 19995976 DOI: 10.1073/Pnas.0912009106  0.685
2009 Lemke EA, Gambin Y, Vandelinder V, Brustad EM, Liu HW, Schultz PG, Groisman A, Deniz AA. Microfluidic device for single-molecule experiments with enhanced photostability. Journal of the American Chemical Society. 131: 13610-2. PMID 19772358 DOI: 10.1021/Ja9027023  0.719
2009 Liu CC, Mack AV, Brustad EM, Mills JH, Groff D, Smider VV, Schultz PG. Evolution of proteins with genetically encoded "chemical warheads". Journal of the American Chemical Society. 131: 9616-7. PMID 19555063 DOI: 10.1021/Ja902985E  0.813
2008 Brustad EM, Lemke EA, Schultz PG, Deniz AA. A general and efficient method for the site-specific dual-labeling of proteins for single molecule fluorescence resonance energy transfer. Journal of the American Chemical Society. 130: 17664-5. PMID 19108697 DOI: 10.1021/Ja807430H  0.761
2008 Brustad E, Bushey ML, Brock A, Chittuluru J, Schultz PG. A promiscuous aminoacyl-tRNA synthetase that incorporates cysteine, methionine, and alanine homologs into proteins. Bioorganic & Medicinal Chemistry Letters. 18: 6004-6. PMID 18845434 DOI: 10.1016/J.Bmcl.2008.09.050  0.793
2008 Brustad E, Bushey ML, Lee JW, Groff D, Liu W, Schultz PG. A genetically encoded boronate-containing amino acid. Angewandte Chemie (International Ed. in English). 47: 8220-3. PMID 18816552 DOI: 10.1002/anie.200803240  0.762
2007 Liu CC, Brustad E, Liu W, Schultz PG. Crystal structure of a biosynthetic sulfo-hirudin complexed to thrombin. Journal of the American Chemical Society. 129: 10648-9. PMID 17685615 DOI: 10.1021/Ja0735002  0.586
2006 Bose M, Groff D, Xie J, Brustad E, Schultz PG. The incorporation of a photoisomerizable amino acid into proteins in E. coli. Journal of the American Chemical Society. 128: 388-9. PMID 16402807 DOI: 10.1021/Ja055467U  0.809
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