Howard J. Jacob - Publications

Affiliations: 
HudsonAlpha Institute for Biotechnology, Huntsville, AL, United States 

264 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Kurki MI, Karjalainen J, Palta P, Sipilä TP, Kristiansson K, Donner KM, Reeve MP, Laivuori H, Aavikko M, Kaunisto MA, Loukola A, Lahtela E, Mattsson H, Laiho P, Della Briotta Parolo P, ... ... Jacob H, et al. Author Correction: FinnGen provides genetic insights from a well-phenotyped isolated population. Nature. PMID 36829046 DOI: 10.1038/s41586-023-05837-8  0.379
2023 Kurki MI, Karjalainen J, Palta P, Sipilä TP, Kristiansson K, Donner KM, Reeve MP, Laivuori H, Aavikko M, Kaunisto MA, Loukola A, Lahtela E, Mattsson H, Laiho P, Della Briotta Parolo P, ... ... Jacob H, et al. FinnGen provides genetic insights from a well-phenotyped isolated population. Nature. 613: 508-518. PMID 36653562 DOI: 10.1038/s41586-022-05473-8  0.432
2022 Karczewski KJ, Solomonson M, Chao KR, Goodrich JK, Tiao G, Lu W, Riley-Gillis BM, Tsai EA, Kim HI, Zheng X, Rahimov F, Esmaeeli S, Grundstad AJ, Reppell M, Waring J, ... Jacob H, et al. Systematic single-variant and gene-based association testing of thousands of phenotypes in 394,841 UK Biobank exomes. Cell Genomics. 2: 100168. PMID 36778668 DOI: 10.1016/j.xgen.2022.100168  0.451
2020 Fan F, Geurts AM, Pabbidi MR, Ge Y, Zhang C, Wang S, Liu Y, Gao W, Guo Y, Li L, He X, Lv W, Muroya Y, Hirata T, Prokop J, ... ... Jacob HJ, et al. A Mutation in -Adducin Impairs Autoregulation of Renal Blood Flow and Promotes the Development of Kidney Disease. Journal of the American Society of Nephrology : Jasn. PMID 32029431 DOI: 10.1681/Asn.2019080784  0.619
2018 Levy H, Jia S, Pan A, Zhang X, Kaldunski ML, Nugent ML, Reske M, Feliciano RA, Quintero D, Renda MM, Woods KJ, Murkowski K, Johnson K, Verbsky J, Dasu T, ... ... Jacob H, et al. Identification of molecular signatures of cystic fibrosis disease status using plasma-based functional genomics. Physiological Genomics. PMID 30540547 DOI: 10.1152/Physiolgenomics.00109.2018  0.312
2018 Prokop JW, Yeo NC, Ottmann C, Chhetri SB, Florus KL, Ross EJ, Sosonkina N, Link BA, Freedman BI, Coppola CJ, McDermott-Roe C, Leysen S, Milroy LG, Meijer FA, Geurts AM, ... ... Jacob HJ, et al. Characterization of Coding/Noncoding Variants forin Patients with CKD. Journal of the American Society of Nephrology : Jasn. PMID 29476007 DOI: 10.1681/Asn.2017080856  0.641
2017 Palygin O, Levchenko V, Ilatovskaya DV, Pavlov TS, Pochynyuk OM, Jacob HJ, Geurts AM, Hodges MR, Staruschenko A. Essential role of Kir5.1 channels in renal salt handling and blood pressure control. Jci Insight. 2. PMID 28931751 DOI: 10.1172/Jci.Insight.92331  0.38
2017 Bick D, Fraser PC, Gutzeit MF, Harris JM, Hambuch TM, Helbling DC, Jacob HJ, Kersten JN, Leuthner SR, May T, North PE, Prisco SZ, Schuler BA, Shimoyama M, Strong KA, et al. Successful Application of Whole Genome Sequencing in a Medical Genetics Clinic. Journal of Pediatric Genetics. 6: 61-76. PMID 28496993 DOI: 10.1055/S-0036-1593968  0.343
2017 Manolio TA, Fowler DM, Starita LM, Haendel MA, MacArthur DG, Biesecker LG, Worthey E, Chisholm RL, Green ED, Jacob HJ, McLeod HL, Roden D, Rodriguez LL, Williams MS, Cooper GM, et al. Bedside Back to Bench: Building Bridges between Basic and Clinical Genomic Research. Cell. 169: 6-12. PMID 28340351 DOI: 10.1016/J.Cell.2017.03.005  0.388
2017 Prokop JW, Lazar J, Crapitto G, Smith DC, Worthey EA, Jacob HJ. Molecular modeling in the age of clinical genomics, the enterprise of the next generation. Journal of Molecular Modeling. 23: 75. PMID 28204942 DOI: 10.1007/S00894-017-3258-3  0.619
2017 Prokop JW, Smith C, Bilinovich SM, Williams DC, Jacob HJ. Transcription Factor-DNA Interaction: From Encode to Biophysics using Evolution and Molecular Dynamic Simulations Biophysical Journal. 112: 292a. DOI: 10.1016/J.Bpj.2016.11.1581  0.597
2016 Miller B, Palygin O, Rufanova VA, Chong A, Lazar J, Jacob HJ, Mattson D, Roman RJ, Williams JM, Cowley AW, Geurts AM, Staruschenko A, Imig JD, Sorokin A. p66Shc regulates renal vascular tone in hypertension-induced nephropathy. The Journal of Clinical Investigation. PMID 27270176 DOI: 10.1172/Jci75079  0.341
2016 Prokop JW, Tsaih SW, Faber AB, Boehme S, Underwood AC, Troyer S, Playl L, Milsted A, Turner ME, Ely D, Martins AS, Tutaj M, Lazar J, Dwinell MR, Jacob HJ. The phenotypic impact of the male-specific region of chromosome-Y in inbred mating: the role of genetic variants and gene duplications in multiple inbred rat strains. Biology of Sex Differences. 7: 10. PMID 26848384 DOI: 10.1186/S13293-016-0064-Z  0.781
2016 Delaney SK, Hultner ML, Jacob HJ, Ledbetter DH, McCarthy JJ, Ball M, Beckman KB, Belmont JW, Bloss CS, Christman MF, Cosgrove A, Damiani SA, Danis T, Delledonne M, Dougherty MJ, et al. Toward clinical genomics in everyday medicine: perspectives and recommendations. Expert Review of Molecular Diagnostics. PMID 26810587 DOI: 10.1586/14737159.2016.1146593  0.309
2016 Bergom C, Straza M, Rymaszewski A, Frei A, Lemke A, Tsaih S, Jacob H, Flister MJ. Abstract B07: Utilizing consomic xenograft models to identify genetic variants in the tumor microenvironment that determine breast cancer radiation responses Cancer Research. 76. DOI: 10.1158/1538-7445.Tme16-B07  0.329
2015 Teumer A, Tin A, Sorice R, Gorski M, Yeo NC, Chu AY, Li M, Li Y, Mijatovic V, Ko YA, Taliun D, Luciani A, Chen MH, Yang Q, Foster MC, ... ... Jacob HJ, et al. Genome-wide Association Studies Identify Genetic Loci Associated with Albuminuria in Diabetes. Diabetes. PMID 26631737 DOI: 10.2337/Db15-1313  0.37
2015 Cowley AW, Yang C, Kumar V, Lazar J, Jacob H, Geurts AM, Liu P, Dayton A, Kurth T, Liang M. PAPPA2 IS LINKED TO SALT-SENSITIVE HYPERTENSION IN DAHL S RATS. Physiological Genomics. physiolgenomics.0009. PMID 26534937 DOI: 10.1152/Physiolgenomics.00097.2015  0.452
2015 Wang F, Zhang G, Lu Z, Geurts AM, Usa K, Jacob HJ, Cowley AW, Wang N, Liang M. Antithrombin III/SerpinC1 insufficiency exacerbates renal ischemia/reperfusion injury. Kidney International. PMID 26108065 DOI: 10.1038/Ki.2015.176  0.315
2015 Holditch SJ, Schreiber CA, Nini R, Tonne JM, Peng KW, Geurts A, Jacob HJ, Burnett JC, Cataliotti A, Ikeda Y. B-Type Natriuretic Peptide Deletion Leads to Progressive Hypertension, Associated Organ Damage, and Reduced Survival: Novel Model for Human Hypertension. Hypertension. 66: 199-210. PMID 26063669 DOI: 10.1161/Hypertensionaha.115.05610  0.399
2015 Xia S, Kohli M, Du M, Dittmar RL, Lee A, Nandy D, Yuan T, Guo Y, Wang Y, Tschannen MR, Worthey E, Jacob H, See W, Kilari D, Wang X, et al. Plasma genetic and genomic abnormalities predict treatment response and clinical outcome in advanced prostate cancer. Oncotarget. 6: 16411-21. PMID 25915538 DOI: 10.18632/Oncotarget.3845  0.32
2015 Rudemiller NP, Lund H, Priestley JR, Endres BT, Prokop JW, Jacob HJ, Geurts AM, Cohen EP, Mattson DL. Mutation of SH2B3 (LNK), a genome-wide association study candidate for hypertension, attenuates Dahl salt-sensitive hypertension via inflammatory modulation. Hypertension. 65: 1111-7. PMID 25776069 DOI: 10.1161/Hypertensionaha.114.04736  0.661
2015 Flister MJ, Hoffman MJ, Lemke A, Prisco SZ, Rudemiller N, O'Meara CC, Tsaih SW, Moreno C, Geurts AM, Lazar J, Adhikari N, Hall JL, Jacob HJ. SH2B3 Is a Genetic Determinant of Cardiac Inflammation and Fibrosis. Circulation. Cardiovascular Genetics. 8: 294-304. PMID 25628389 DOI: 10.1161/Circgenetics.114.000527  0.326
2015 Fan F, Geurts AM, Murphy SR, Pabbidi MR, Jacob HJ, Roman RJ. Impaired myogenic response and autoregulation of cerebral blood flow is rescued in CYP4A1 transgenic Dahl salt-sensitive rat. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 308: R379-90. PMID 25540098 DOI: 10.1152/Ajpregu.00256.2014  0.42
2015 Shimoyama M, De Pons J, Hayman GT, Laulederkind SJ, Liu W, Nigam R, Petri V, Smith JR, Tutaj M, Wang SJ, Worthey E, Dwinell M, Jacob H. The Rat Genome Database 2015: genomic, phenotypic and environmental variations and disease. Nucleic Acids Research. 43: D743-50. PMID 25355511 DOI: 10.1093/Nar/Gku1026  0.433
2015 Yeo NC, O'Meara CC, Bonomo JA, Veth KN, Tomar R, Flister MJ, Drummond IA, Bowden DW, Freedman BI, Lazar J, Link BA, Jacob HJ. Shroom3 contributes to the maintenance of the glomerular filtration barrier integrity. Genome Research. 25: 57-65. PMID 25273069 DOI: 10.1101/Gr.182881.114  0.495
2015 Prokop JW, Petri V, Shimoyama ME, Watanabe IK, Casarini DE, Leeper TC, Bilinovich SM, Jacob HJ, Santos RA, Martins AS, Araujo FC, Reis FM, Milsted A. Structural libraries of protein models for multiple species to understand evolution of the renin-angiotensin system. General and Comparative Endocrinology. 215: 106-16. PMID 25260253 DOI: 10.1016/J.Ygcen.2014.09.010  0.755
2015 Li L, Chen E, Yang C, Zhu J, Jayaraman P, De Pons J, Kaczorowski CC, Jacob HJ, Greene AS, Hodges MR, Cowley AW, Liang M, Xu H, Liu P, Lu Y. Improved rat genome gene prediction by integration of ESTs with RNA-Seq information. Bioinformatics (Oxford, England). 31: 25-32. PMID 25217576 DOI: 10.1093/Bioinformatics/Btu608  0.419
2015 Du M, Yuan T, Schilter KF, Dittmar RL, Mackinnon A, Huang X, Tschannen M, Worthey E, Jacob H, Xia S, Gao J, Tillmans L, Lu Y, Liu P, Thibodeau SN, et al. Prostate cancer risk locus at 8q24 as a regulatory hub by physical interactions with multiple genomic loci across the genome. Human Molecular Genetics. 24: 154-66. PMID 25149474 DOI: 10.1093/Hmg/Ddu426  0.364
2015 Flister MJ, Stoddard A, Tsaih S, Lemke A, Lazar J, Jacob H. Abstract PR16: New tools for mapping genetic modifiers of cancer risk in the tumor microenvironment Cancer Research. 75. DOI: 10.1158/1538-7445.Transcagen-Pr16  0.413
2015 Flister MJ, Stoddard A, Tsaih S, Lemke A, Lazar J, Jacob H. Abstract PR08: New tools for mapping genetic modifiers of cancer risk in the tumor microenvironment Cancer Research. 75. DOI: 10.1158/1538-7445.Compsysbio-Pr08  0.406
2015 Flister M, Lemke A, Dwinell M, Bergom C, Shull J, Jacob H. Abstract 3217: NextGen strategies for mapping genetic modifiers in the tumor microenvironment Cancer Research. 75: 3217-3217. DOI: 10.1158/1538-7445.Am2015-3217  0.451
2014 Fan F, Geurts AM, Pabbidi MR, Smith SV, Harder DR, Jacob H, Roman RJ. Zinc-finger nuclease knockout of dual-specificity protein phosphatase-5 enhances the myogenic response and autoregulation of cerebral blood flow in FHH.1BN rats. Plos One. 9: e112878. PMID 25397684 DOI: 10.1371/Journal.Pone.0112878  0.479
2014 Prisco SZ, Priestley JR, Weinberg BD, Prisco AR, Hoffman MJ, Jacob HJ, Flister MJ, Lombard JH, Lazar J. Vascular dysfunction precedes hypertension associated with a blood pressure locus on rat chromosome 12. American Journal of Physiology. Heart and Circulatory Physiology. 307: H1103-10. PMID 25320330 DOI: 10.1152/Ajpheart.00464.2014  0.444
2014 Petri V, Hayman GT, Tutaj M, Smith JR, Laulederkind SJ, Wang SJ, Nigam R, De Pons J, Shimoyama M, Dwinell MR, Worthey EA, Jacob HJ. Disease pathways at the Rat Genome Database Pathway Portal: genes in context-a network approach to understanding the molecular mechanisms of disease. Human Genomics. 8: 17. PMID 25265995 DOI: 10.1186/S40246-014-0017-8  0.355
2014 Tsaih SW, Holl K, Jia S, Kaldunski M, Tschannen M, He H, Andrae JW, Li SH, Stoddard A, Wiederhold A, Parrington J, Ruas da Silva M, Galione A, Meigs J, ... ... Jacob H, et al. Identification of a novel gene for diabetic traits in rats, mice, and humans. Genetics. 198: 17-29. PMID 25236446 DOI: 10.1534/Genetics.114.162982  0.389
2014 Flister MJ, Endres BT, Rudemiller N, Sarkis AB, Santarriaga S, Roy I, Lemke A, Geurts AM, Moreno C, Ran S, Tsaih SW, De Pons J, Carlson DF, Tan W, Fahrenkrug SC, ... ... Jacob HJ, et al. CXM: a new tool for mapping breast cancer risk in the tumor microenvironment. Cancer Research. 74: 6419-29. PMID 25172839 DOI: 10.1158/0008-5472.Can-13-3212  0.344
2014 Endres BT, Priestley JR, Palygin O, Flister MJ, Hoffman MJ, Weinberg BD, Grzybowski M, Lombard JH, Staruschenko A, Moreno C, Jacob HJ, Geurts AM. Mutation of Plekha7 attenuates salt-sensitive hypertension in the rat. Proceedings of the National Academy of Sciences of the United States of America. 111: 12817-22. PMID 25136115 DOI: 10.1073/Pnas.1410745111  0.397
2014 Prisco SZ, Prokop JW, Sarkis AB, Yeo NC, Hoffman MJ, Hansen CC, Jacob HJ, Flister MJ, Lazar J. Refined mapping of a hypertension susceptibility locus on rat chromosome 12. Hypertension. 64: 883-90. PMID 25001272 DOI: 10.1161/Hypertensionaha.114.03550  0.672
2014 Jin C, Sun J, Stilphen CA, Smith SM, Ocasio H, Bermingham B, Darji S, Guha A, Patel R, Geurts AM, Jacob HJ, Lambert NA, O'Connor PM. HV1 acts as a sodium sensor and promotes superoxide production in medullary thick ascending limb of Dahl salt-sensitive rats. Hypertension. 64: 541-50. PMID 24935944 DOI: 10.1161/Hypertensionaha.114.03549  0.416
2014 Cowley AW, Moreno C, Jacob HJ, Peterson CB, Stingo FC, Ahn KW, Liu P, Vannucci M, Laud PW, Reddy P, Lazar J, Evans L, Yang C, Kurth T, Liang M. Characterization of biological pathways associated with a 1.37 Mbp genomic region protective of hypertension in Dahl S rats. Physiological Genomics. 46: 398-410. PMID 24714719 DOI: 10.1152/Physiolgenomics.00179.2013  0.463
2014 Jacob HJ. Genetic diagnosis through whole-exome sequencing. The New England Journal of Medicine. 370: 1069. PMID 24627900 DOI: 10.1056/Nejmc1315908  0.318
2014 Petri V, Jayaraman P, Tutaj M, Hayman GT, Smith JR, De Pons J, Laulederkind SJ, Lowry TF, Nigam R, Wang SJ, Shimoyama M, Dwinell MR, Munzenmaier DH, Worthey EA, Jacob HJ. The pathway ontology - updates and applications. Journal of Biomedical Semantics. 5: 7. PMID 24499703 DOI: 10.1186/2041-1480-5-7  0.361
2014 Beyer AM, Raffai G, Weinberg BD, Fredrich K, Rodgers MS, Geurts AM, Jacob HJ, Dwinell MR, Lombard JH. Amelioration of salt-induced vascular dysfunction in mesenteric arteries of Dahl salt-sensitive rats by missense mutation of extracellular superoxide dismutase. American Journal of Physiology. Heart and Circulatory Physiology. 306: H339-47. PMID 24322611 DOI: 10.1152/Ajpheart.00619.2012  0.392
2014 McPherson K, White T, Johnson A, Geurts A, Jacob H, Garrett M, Williams J. Initial characterization of leptin receptor knockout Dahl salt-sensitive rats (1121.2) The Faseb Journal. 28. DOI: 10.1096/Fasebj.28.1_Supplement.1121.2  0.312
2013 Nigam R, Munzenmaier DH, Worthey EA, Dwinell MR, Shimoyama M, Jacob HJ. Rat Strain Ontology: structured controlled vocabulary designed to facilitate access to strain data at RGD. Journal of Biomedical Semantics. 4: 36. PMID 24267899 DOI: 10.1186/2041-1480-4-36  0.409
2013 Jacob HJ. Next-generation sequencing for clinical diagnostics. The New England Journal of Medicine. 369: 1557-8. PMID 24088040 DOI: 10.1056/Nejme1310846  0.309
2013 Kaczorowski CC, Stodola TJ, Hoffmann BR, Prisco AR, Liu PY, Didier DN, Karcher JR, Liang M, Jacob HJ, Greene AS. Targeting the endothelial progenitor cell surface proteome to identify novel mechanisms that mediate angiogenic efficacy in a rodent model of vascular disease. Physiological Genomics. 45: 999-1011. PMID 24022221 DOI: 10.1152/Physiolgenomics.00097.2013  0.316
2013 Flister MJ, Tsaih SW, O'Meara CC, Endres B, Hoffman MJ, Geurts AM, Dwinell MR, Lazar J, Jacob HJ, Moreno C. Identifying multiple causative genes at a single GWAS locus. Genome Research. 23: 1996-2002. PMID 24006081 DOI: 10.1101/Gr.160283.113  0.446
2013 Atanur SS, Diaz AG, Maratou K, Sarkis A, Rotival M, Game L, Tschannen MR, Kaisaki PJ, Otto GW, Ma MC, Keane TM, Hummel O, Saar K, Chen W, Guryev V, ... ... Jacob H, et al. Genome sequencing reveals loci under artificial selection that underlie disease phenotypes in the laboratory rat. Cell. 154: 691-703. PMID 23890820 DOI: 10.1016/J.Cell.2013.06.040  0.516
2013 Nigam R, Laulederkind SJ, Hayman GT, Smith JR, Wang SJ, Lowry TF, Petri V, De Pons J, Tutaj M, Liu W, Jayaraman P, Munzenmaier DH, Worthey EA, Dwinell MR, Shimoyama M, ... Jacob HJ, et al. Rat Genome Database: a unique resource for rat, human, and mouse quantitative trait locus data. Physiological Genomics. 45: 809-16. PMID 23881287 DOI: 10.1152/Physiolgenomics.00065.2013  0.507
2013 Hoffman MJ, Flister MJ, Nunez L, Xiao B, Greene AS, Jacob HJ, Moreno C. Female-specific hypertension loci on rat chromosome 13. Hypertension. 62: 557-63. PMID 23817491 DOI: 10.1161/Hypertensionaha.113.01708  0.47
2013 Wang SJ, Laulederkind SJ, Hayman GT, Smith JR, Petri V, Lowry TF, Nigam R, Dwinell MR, Worthey EA, Munzenmaier DH, Shimoyama M, Jacob HJ. Analysis of disease-associated objects at the Rat Genome Database. Database : the Journal of Biological Databases and Curation. 2013: bat046. PMID 23794737 DOI: 10.1093/Database/Bat046  0.464
2013 Lazar J, O'Meara CC, Sarkis AB, Prisco SZ, Xu H, Fox CS, Chen MH, Broeckel U, Arnett DK, Moreno C, Provoost AP, Jacob HJ. SORCS1 contributes to the development of renal disease in rats and humans. Physiological Genomics. 45: 720-8. PMID 23780848 DOI: 10.1152/Physiolgenomics.00089.2013  0.486
2013 Yang S, Takizawa A, Foeckler J, Zappa A, Gjoka M, Schilling R, Hansen C, Xu H, Kalloway S, Grzybowski M, Davis GD, Jacob HJ, Geurts AM. Derivation and genetic modification of embryonic stem cells from disease-model inbred rat strains. Stem Cells and Development. PMID 23635087 DOI: 10.1089/Scd.2012.0416  0.515
2013 Flister MJ, Hoffman MJ, Reddy P, Jacob HJ, Moreno C. Congenic mapping and sequence analysis of the Renin locus. Hypertension. 61: 850-6. PMID 23460292 DOI: 10.1161/Hypertensionaha.111.01008  0.449
2013 Laulederkind SJ, Hayman GT, Wang SJ, Smith JR, Lowry TF, Nigam R, Petri V, de Pons J, Dwinell MR, Shimoyama M, Munzenmaier DH, Worthey EA, Jacob HJ. The Rat Genome Database 2013--data, tools and users. Briefings in Bioinformatics. 14: 520-6. PMID 23434633 DOI: 10.1093/Bib/Bbt007  0.399
2013 Schuler BA, Prisco SZ, Jacob HJ. Using whole exome sequencing to walk from clinical practice to research and back again. Circulation. 127: 968-70. PMID 23388216 DOI: 10.1161/Circulationaha.113.001284  0.367
2013 Mattson DL, Lund H, Guo C, Rudemiller N, Geurts AM, Jacob H. Genetic mutation of recombination activating gene 1 in Dahl salt-sensitive rats attenuates hypertension and renal damage. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 304: R407-14. PMID 23364523 DOI: 10.1152/Ajpregu.00304.2012  0.42
2013 Rangel-Filho A, Lazar J, Moreno C, Geurts A, Jacob HJ. Rab38 modulates proteinuria in model of hypertension-associated renal disease. Journal of the American Society of Nephrology : Jasn. 24: 283-92. PMID 23291471 DOI: 10.1681/Asn.2012090927  0.465
2013 Chen CC, Geurts AM, Jacob HJ, Fan F, Roman RJ. Heterozygous knockout of transforming growth factor-β1 protects Dahl S rats against high salt-induced renal injury. Physiological Genomics. 45: 110-8. PMID 23249995 DOI: 10.1152/Physiolgenomics.00119.2012  0.331
2013 Burke M, Pabbidi M, Fan F, Ge Y, Liu R, Williams JM, Sarkis A, Lazar J, Jacob HJ, Roman RJ. Genetic basis of the impaired renal myogenic response in FHH rats. American Journal of Physiology. Renal Physiology. 304: F565-77. PMID 23220727 DOI: 10.1152/Ajprenal.00404.2012  0.452
2013 Katter K, Geurts AM, Hoffmann O, Mátés L, Landa V, Hiripi L, Moreno C, Lazar J, Bashir S, Zidek V, Popova E, Jerchow B, Becker K, Devaraj A, Walter I, ... ... Jacob HJ, et al. Transposon-mediated transgenesis, transgenic rescue, and tissue-specific gene expression in rodents and rabbits. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 930-41. PMID 23195032 DOI: 10.1096/Fj.12-205526  0.426
2013 Yang C, Stingo FC, Ahn KW, Liu P, Vannucci M, Laud PW, Skelton M, O'Connor P, Kurth T, Ryan RP, Moreno C, Tsaih SW, Patone G, Hummel O, Jacob HJ, et al. Increased proliferative cells in the medullary thick ascending limb of the loop of Henle in the Dahl salt-sensitive rat. Hypertension. 61: 208-15. PMID 23184381 DOI: 10.1161/Hypertensionaha.112.199380  0.448
2013 Pabbidi MR, Juncos J, Juncos L, Renic M, Tullos HJ, Lazar J, Jacob HJ, Harder DR, Roman RJ. Identification of a region of rat chromosome 1 that impairs the myogenic response and autoregulation of cerebral blood flow in fawn-hooded hypertensive rats. American Journal of Physiology. Heart and Circulatory Physiology. 304: H311-7. PMID 23144316 DOI: 10.1152/Ajpheart.00622.2012  0.351
2012 Laulederkind SJ, Hayman GT, Wang SJ, Lowry TF, Nigam R, Petri V, Smith JR, Dwinell MR, Jacob HJ, Shimoyama M. Exploring genetic, genomic, and phenotypic data at the rat genome database. Current Protocols in Bioinformatics / Editoral Board, Andreas D. Baxevanis ... [Et Al.]. Unit1.14. PMID 23255149 DOI: 10.1002/0471250953.Bi0114S40  0.505
2012 Flister MJ, Prisco SZ, Sarkis AB, O'Meara CC, Hoffman M, Wendt-Andrae J, Moreno C, Lazar J, Jacob HJ. Identification of hypertension susceptibility loci on rat chromosome 12. Hypertension. 60: 942-8. PMID 22868394 DOI: 10.1161/Hypertensionaha.112.198200  0.418
2012 Solberg Woods LC, Woods BC, Leitschuh CM, Laurie SJ, Jacob HJ. Rat chromosome 8 confers protection against dyslipidemia caused by a high-fat/low-carbohydrate diet. Journal of Nutrigenetics and Nutrigenomics. 5: 81-93. PMID 22722880 DOI: 10.1159/000338848  0.396
2012 O'Meara CC, Hoffman M, Sweeney WE, Tsaih SW, Xiao B, Jacob HJ, Avner ED, Moreno C. Role of genetic modifiers in an orthologous rat model of ARPKD. Physiological Genomics. 44: 741-53. PMID 22669842 DOI: 10.1152/Physiolgenomics.00187.2011  0.458
2012 Sethumadhavan S, Vasquez-Vivar J, Migrino RQ, Harmann L, Jacob HJ, Lazar J. Mitochondrial DNA variant for complex I reveals a role in diabetic cardiac remodeling. The Journal of Biological Chemistry. 287: 22174-82. PMID 22544750 DOI: 10.1074/Jbc.M111.327866  0.367
2012 Williams JM, Fan F, Murphy S, Schreck C, Lazar J, Jacob HJ, Roman RJ. Role of 20-HETE in the antihypertensive effect of transfer of chromosome 5 from Brown Norway to Dahl salt-sensitive rats. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 302: R1209-18. PMID 22442195 DOI: 10.1152/Ajpregu.00604.2011  0.448
2012 Laulederkind SJ, Tutaj M, Shimoyama M, Hayman GT, Lowry TF, Nigam R, Petri V, Smith JR, Wang SJ, de Pons J, Dwinell MR, Jacob HJ. Ontology searching and browsing at the Rat Genome Database. Database : the Journal of Biological Databases and Curation. 2012: bas016. PMID 22434847 DOI: 10.1093/Database/Bas016  0.435
2012 Green RC, Berg JS, Berry GT, Biesecker LG, Dimmock DP, Evans JP, Grody WW, Hegde MR, Kalia S, Korf BR, Krantz I, McGuire AL, Miller DT, Murray MF, Nussbaum RL, ... ... Jacob HJ, et al. Exploring concordance and discordance for return of incidental findings from clinical sequencing. Genetics in Medicine : Official Journal of the American College of Medical Genetics. 14: 405-10. PMID 22422049 DOI: 10.1038/Gim.2012.21  0.317
2012 O'Meara CC, Lutz MM, Sarkis AB, Xu H, Kothinti RK, Hoffman M, Moreno C, Tabatabai NM, Lazar J, Roman RJ, Jacob HJ. A 4.1-Mb congenic region of Rf-4 contributes to glomerular permeability. Journal of the American Society of Nephrology : Jasn. 23: 825-33. PMID 22343117 DOI: 10.1681/Asn.2011080805  0.479
2012 Worthey E, Bick D, Dimmock D, Shimoyama M, Veith R, Kowalski G, Taylor B, Wilk B, Tsaih S, Harris J, Tschannen M, Wendt-Andrae J, Brodie K, Jacob H. Clinical diagnostic whole genome sequencing in a paediatric population: experience from our WGS genetics clinic Bmc Proceedings. 6: 1-2. DOI: 10.1186/1753-6561-6-S6-O11  0.353
2012 Sarkis AB, Flister MJ, Tsaih S, Atanur SS, Aitman TJ, Hubner N, Hummel O, Moreno C, Lazar J, Jacob HJ. 132 USE OF NEXT GENERATION SEQUENCING IN GENETIC DISSECTION OF HYPERTENSION Journal of Hypertension. 30: e40. DOI: 10.1097/01.Hjh.0000419952.22139.Bf  0.361
2011 McDermott-Roe C, Ye J, Ahmed R, Sun XM, Serafín A, Ware J, Bottolo L, Muckett P, Cañas X, Zhang J, Rowe GC, Buchan R, Lu H, Braithwaite A, Mancini M, ... ... Jacob H, et al. Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function. Nature. 478: 114-8. PMID 21979051 DOI: 10.1038/Nature10490  0.359
2011 Stodola TJ, de Resende MM, Sarkis AB, Didier DN, Jacob HJ, Huebner N, Hummel O, Saar K, Moreno C, Greene AS. Characterization of the genomic structure and function of regions influencing renin and angiogenesis in the SS rat. Physiological Genomics. 43: 808-17. PMID 21521778 DOI: 10.1152/Physiolgenomics.00171.2010  0.455
2011 Petri V, Shimoyama M, Hayman GT, Smith JR, Tutaj M, de Pons J, Dwinell MR, Munzenmaier DH, Twigger SN, Jacob HJ. The Rat Genome Database pathway portal. Database : the Journal of Biological Databases and Curation. 2011: bar010. PMID 21478484 DOI: 10.1093/Database/Bar010  0.326
2011 Laulederkind SJ, Shimoyama M, Hayman GT, Lowry TF, Nigam R, Petri V, Smith JR, Wang SJ, de Pons J, Kowalski G, Liu W, Rood W, Munzenmaier DH, Dwinell MR, Twigger SN, ... Jacob HJ, et al. The Rat Genome Database curation tool suite: a set of optimized software tools enabling efficient acquisition, organization, and presentation of biological data. Database : the Journal of Biological Databases and Curation. 2011: bar002. PMID 21321022 DOI: 10.1093/Database/Bar002  0.44
2011 Shimoyama M, Smith JR, Hayman T, Laulederkind S, Lowry T, Nigam R, Petri V, Wang SJ, Dwinell M, Jacob H. RGD: a comparative genomics platform. Human Genomics. 5: 124-9. PMID 21296746 DOI: 10.1186/1479-7364-5-2-124  0.492
2011 Moreno C, Williams JM, Lu L, Liang M, Lazar J, Jacob HJ, Cowley AW, Roman RJ. Narrowing a region on rat chromosome 13 that protects against hypertension in Dahl SS-13BN congenic strains. American Journal of Physiology. Heart and Circulatory Physiology. 300: H1530-5. PMID 21257920 DOI: 10.1152/Ajpheart.01026.2010  0.449
2011 Moreno C, Hoffman M, Stodola TJ, Didier DN, Lazar J, Geurts AM, North PE, Jacob HJ, Greene AS. Creation and characterization of a renin knockout rat. Hypertension. 57: 614-9. PMID 21242461 DOI: 10.1161/Hypertensionaha.110.163840  0.467
2011 Mayer AN, Dimmock DP, Arca MJ, Bick DP, Verbsky JW, Worthey EA, Jacob HJ, Margolis DA. A timely arrival for genomic medicine. Genetics in Medicine : Official Journal of the American College of Medical Genetics. 13: 195-6. PMID 21169843 DOI: 10.1097/Gim.0B013E3182095089  0.33
2011 O'Meara CC, Lazar J, Hoffman M, Moreno C, Jacob HJ. Refined mapping of the renal failure RF-3 quantitative trait locus. Journal of the American Society of Nephrology : Jasn. 22: 518-25. PMID 21127141 DOI: 10.1681/Asn.2010060661  0.473
2011 Williams JM, Burke M, Lazar J, Jacob HJ, Roman RJ. Temporal characterization of the development of renal injury in FHH rats and FHH.1BN congenic strains. American Journal of Physiology. Renal Physiology. 300: F330-8. PMID 21048028 DOI: 10.1152/Ajprenal.00261.2010  0.424
2011 Sethumadhavan S, Vasquez-Vivar J, Migrino RQ, Harmann L, Jacob HJ, Lazar J. Myocardial Dysfunction in a New Conplastic Rat Model of Type 2 Diabetes: Assessing the Role of Different Mitochondrial Genomes Free Radical Biology and Medicine. 51: S66. DOI: 10.1016/J.Freeradbiomed.2011.10.171  0.355
2010 Jacob HJ, Lazar J, Dwinell MR, Moreno C, Geurts AM. Gene targeting in the rat: advances and opportunities. Trends in Genetics : Tig. 26: 510-8. PMID 20869786 DOI: 10.1016/J.Tig.2010.08.006  0.468
2010 Adamovic T, McAllister D, Wang T, Adamovic D, Rowe JJ, Moreno C, Lazar J, Jacob HJ, Sugg SL. Identification of novel carcinogen-mediated mammary tumor susceptibility loci in the rat using the chromosome substitution technique. Genes, Chromosomes & Cancer. 49: 1035-45. PMID 20737482 DOI: 10.1002/Gcc.20812  0.472
2010 Yang Y, Dahly-Vernon AJ, Blomme EA, Lai-Zhang J, Kempf DJ, Marsh KC, Harrington YA, Nye SH, Evans DL, Roman RJ, Jacob HJ, Waring JF. Liver transcriptomic changes associated with ritonavir-induced hyperlipidemia in sensitive and resistant strains of rats. Veterinary Journal (London, England : 1997). 185: 75-82. PMID 20547082 DOI: 10.1016/J.Tvjl.2010.04.017  0.424
2010 Shao H, Sinasac DS, Burrage LC, Hodges CA, Supelak PJ, Palmert MR, Moreno C, Cowley AW, Jacob HJ, Nadeau JH. Analyzing complex traits with congenic strains. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 21: 276-86. PMID 20524000 DOI: 10.1007/S00335-010-9267-5  0.357
2010 Geurts AM, Cost GJ, Rémy S, Cui X, Tesson L, Usal C, Ménoret S, Jacob HJ, Anegon I, Buelow R. Generation of gene-specific mutated rats using zinc-finger nucleases. Methods in Molecular Biology (Clifton, N.J.). 597: 211-25. PMID 20013236 DOI: 10.1007/978-1-60327-389-3_15  0.468
2010 Worthey EA, Stoddard AJ, Jacob HJ. Sequencing of the rat genome and databases. Methods in Molecular Biology (Clifton, N.J.). 597: 33-53. PMID 20013224 DOI: 10.1007/978-1-60327-389-3_3  0.466
2010 Jacob HJ. The rat: a model used in biomedical research. Methods in Molecular Biology (Clifton, N.J.). 597: 1-11. PMID 20013222 DOI: 10.1007/978-1-60327-389-3_1  0.351
2010 Lu L, Li P, Yang C, Kurth T, Misale M, Skelton M, Moreno C, Roman RJ, Greene AS, Jacob HJ, Lazar J, Liang M, Cowley AW. Dynamic convergence and divergence of renal genomic and biological pathways in protection from Dahl salt-sensitive hypertension. Physiological Genomics. 41: 63-70. PMID 20009007 DOI: 10.1152/Physiolgenomics.00170.2009  0.475
2010 Laulederkind SJF, Shimoyama M, Taylor B, Petri V, Lowry TF, Hayman GT, Wang S, Smith JR, Nigam R, Pons JD, Liu W, Kowalski G, Dwinell MR, Munzenmaier DH, Jacob HJ. Gene Curation Software at the Rat Genome Database (RGD) Nature Precedings. DOI: 10.1038/Npre.2010.5058.1  0.448
2010 Verbsky J, Syverson G, Bonacci B, Serpe J, Dasu V, Worthey E, Dimmock D, Mayer A, Jacob H, Routes J. A Novel XIAP Mutation Detected by Genome Wide Sequencing Causes Early Onset Inflammatory Bowel Disease Clinical Immunology. 135: S105. DOI: 10.1016/J.Clim.2010.03.315  0.306
2009 Beetz N, Harrison MD, Brede M, Zong X, Urbanski MJ, Sietmann A, Kaufling J, Lorkowski S, Barrot M, Seeliger MW, Vieira-Coelho MA, Hamet P, Gaudet D, Seda O, Tremblay J, ... ... Jacob HJ, et al. Phosducin influences sympathetic activity and prevents stress-induced hypertension in humans and mice. The Journal of Clinical Investigation. 119: 3597-3612. PMID 19959875 DOI: 10.1172/Jci38433  0.319
2009 Shimoyama M, Hayman GT, Laulederkind SJ, Nigam R, Lowry TF, Petri V, Smith JR, Wang SJ, Munzenmaier DH, Dwinell MR, Twigger SN, Jacob HJ. The rat genome database curators: who, what, where, why. Plos Computational Biology. 5: e1000582. PMID 19956751 DOI: 10.1371/Journal.Pcbi.1000582  0.399
2009 Temple G, Gerhard DS, Rasooly R, Feingold EA, Good PJ, Robinson C, Mandich A, Derge JG, Lewis J, Shoaf D, Collins FS, Jang W, Wagner L, Shenmen CM, ... ... Jacob H, et al. The completion of the Mammalian Gene Collection (MGC). Genome Research. 19: 2324-33. PMID 19767417 DOI: 10.1101/Gr.095976.109  0.372
2009 Geurts AM, Cost GJ, Freyvert Y, Zeitler B, Miller JC, Choi VM, Jenkins SS, Wood A, Cui X, Meng X, Vincent A, Lam S, Michalkiewicz M, Schilling R, Foeckler J, ... ... Jacob HJ, et al. Knockout rats via embryo microinjection of zinc-finger nucleases. Science (New York, N.Y.). 325: 433. PMID 19628861 DOI: 10.1126/Science.1172447  0.455
2009 Nobrega MA, Solberg Woods LC, Fleming S, Jacob HJ. Distinct genetic regulation of progression of diabetes and renal disease in the Goto-Kakizaki rat. Physiological Genomics. 39: 38-46. PMID 19584172 DOI: 10.1152/Physiolgenomics.90389.2008  0.356
2009 Adamovic T, McAllister D, Guryev V, Wang X, Andrae JW, Cuppen E, Jacob HJ, Sugg SL. Microalterations of inherently unstable genomic regions in rat mammary carcinomas as revealed by long oligonucleotide array-based comparative genomic hybridization Cancer Research. 69: 5159-5167. PMID 19509235 DOI: 10.1158/0008-5472.Can-08-4038  0.423
2009 Aneas I, Rodrigues MV, Pauletti BA, Silva GJ, Carmona R, Cardoso L, Kwitek AE, Jacob HJ, Soler JM, Krieger JE. Congenic strains provide evidence that four mapped loci in chromosomes 2, 4, and 16 influence hypertension in the SHR. Physiological Genomics. 37: 52-7. PMID 19126752 DOI: 10.1152/Physiolgenomics.90299.2008  0.44
2009 Dwinell MR, Worthey EA, Shimoyama M, Bakir-Gungor B, DePons J, Laulederkind S, Lowry T, Nigram R, Petri V, Smith J, Stoddard A, Twigger SN, Jacob HJ. The Rat Genome Database 2009: variation, ontologies and pathways. Nucleic Acids Research. 37: D744-9. PMID 18996890 DOI: 10.1093/Nar/Gkn842  0.483
2008 Bilusić M, Moreno C, Barreto NE, Tschannen MR, Harris EL, Porteous WK, Thompson CM, Grigor MR, Weder A, Boerwinkle E, Hunt SC, Curb JD, Jacob HJ, Kwitek AE. Genetically hypertensive Brown Norway congenic rat strains suggest intermediate traits underlying genetic hypertension. Croatian Medical Journal. 49: 586-99. PMID 18925692 DOI: 10.3325/Cmj.2008.5.586  0.49
2008 Williams JM, Sarkis A, Hoagland KM, Fredrich K, Ryan RP, Moreno C, Lopez B, Lazar J, Fenoy FJ, Sharma M, Garrett MR, Jacob HJ, Roman RJ. Transfer of the CYP4A region of chromosome 5 from Lewis to Dahl S rats attenuates renal injury. American Journal of Physiology. Renal Physiology. 295: F1764-77. PMID 18842817 DOI: 10.1152/Ajprenal.90525.2008  0.394
2008 Adamovic T, McAllister D, Rowe JJ, Wang T, Jacob HJ, Sugg SL. Genetic mapping of mammary tumor traits to rat chromosome 10 using a novel panel of consomic rats Cancer Genetics and Cytogenetics. 186: 41-48. PMID 18786441 DOI: 10.1016/J.Cancergencyto.2008.05.014  0.482
2008 Mattson DL, Dwinell MR, Greene AS, Kwitek AE, Roman RJ, Jacob HJ, Cowley AW. Chromosome substitution reveals the genetic basis of Dahl salt-sensitive hypertension and renal disease. American Journal of Physiology. Renal Physiology. 295: F837-42. PMID 18653478 DOI: 10.1152/Ajprenal.90341.2008  0.508
2008 Guryev V, Saar K, Adamovic T, Verheul M, van Heesch SA, Cook S, Pravenec M, Aitman T, Jacob H, Shull JD, Hubner N, Cuppen E. Distribution and functional impact of DNA copy number variation in the rat. Nature Genetics. 40: 538-45. PMID 18443591 DOI: 10.1038/Ng.141  0.496
2008 Twigger SN, Pruitt KD, Fernández-Suárez XM, Karolchik D, Worley KC, Maglott DR, Brown G, Weinstock G, Gibbs RA, Kent J, Birney E, Jacob HJ. What everybody should know about the rat genome and its online resources. Nature Genetics. 40: 523-7. PMID 18443589 DOI: 10.1038/Ng0508-523  0.461
2008 Aitman TJ, Critser JK, Cuppen E, Dominiczak A, Fernandez-Suarez XM, Flint J, Gauguier D, Geurts AM, Gould M, Harris PC, Holmdahl R, Hubner N, Izsvák Z, Jacob HJ, Kuramoto T, et al. Progress and prospects in rat genetics: a community view. Nature Genetics. 40: 516-22. PMID 18443588 DOI: 10.1038/Ng.147  0.516
2008 Liang M, Lee NH, Wang H, Greene AS, Kwitek AE, Kaldunski ML, Luu TV, Frank BC, Bugenhagen S, Jacob HJ, Cowley AW. Molecular networks in Dahl salt-sensitive hypertension based on transcriptome analysis of a panel of consomic rats. Physiological Genomics. 34: 54-64. PMID 18430809 DOI: 10.1152/Physiolgenomics.00031.2008  0.477
2008 Moreno C, Lazar J, Jacob HJ, Kwitek AE. Comparative genomics for detecting human disease genes. Advances in Genetics. 60: 655-97. PMID 18358336 DOI: 10.1016/S0065-2660(07)00423-3  0.414
2008 Gilibert S, Kwitek AE, Hubner N, Tschannen M, Jacob HJ, Sassard J, Bataillard AP. Effects of chromosome 17 on features of the metabolic syndrome in the Lyon hypertensive rat Physiological Genomics. 33: 212-217. PMID 18285521 DOI: 10.1152/Physiolgenomics.00262.2007  0.312
2008 Harris MA, Deegan JI, Ireland A, Lomax J, Ashburner M, Tweedie S, Carbon S, Lewis S, Mungall C, Day-Richter J, Eilbeck K, Blake JA, Bult C, Diehl AD, Dolan M, ... ... Jacob H, et al. The Gene Ontology project in 2008 Nucleic Acids Research. 36. PMID 17984083 DOI: 10.1093/Nar/Gkm883  0.323
2008 Nye SH, Wittenburg AL, Evans DL, O'Connor JA, Roman RJ, Jacob HJ. Rat survival to anthrax lethal toxin is likely controlled by a single gene. The Pharmacogenomics Journal. 8: 16-22. PMID 17440430 DOI: 10.1038/Sj.Tpj.6500448  0.404
2007 Mattson DL, Dwinell MR, Greene AS, Kwitek AE, Roman RJ, Cowley AW, Jacob HJ. Chromosomal mapping of the genetic basis of hypertension and renal disease in FHH rats. American Journal of Physiology. Renal Physiology. 293: F1905-14. PMID 17898042 DOI: 10.1152/Ajprenal.00012.2007  0.477
2007 Moreno C, Kaldunski ML, Wang T, Roman RJ, Greene AS, Lazar J, Jacob HJ, Cowley AW. Multiple blood pressure loci on rat chromosome 13 attenuate development of hypertension in the Dahl S hypertensive rat. Physiological Genomics. 31: 228-35. PMID 17566075 DOI: 10.1152/Physiolgenomics.00280.2006  0.477
2007 Broeckel U, Hengstenberg C, Mayer B, Maresso K, Gaudet D, Seda O, Tremblay J, Holmer S, Erdmann J, Glöckner C, Harrison M, Martin LJ, Williams JT, Schmitz G, Riegger GA, ... Jacob HJ, et al. A locus on chromosome 10 influences C-reactive protein levels in two independent populations. Human Genetics. 122: 95-102. PMID 17530289 DOI: 10.1007/S00439-007-0380-9  0.377
2007 Michalkiewicz M, Michalkiewicz T, Geurts AM, Roman RJ, Slocum GR, Singer O, Weihrauch D, Greene AS, Kaldunski M, Verma IM, Jacob HJ, Cowley AW. Efficient transgenic rat production by a lentiviral vector. American Journal of Physiology. Heart and Circulatory Physiology. 293: H881-94. PMID 17322424 DOI: 10.1152/Ajpheart.00060.2007  0.417
2007 Twigger SN, Shimoyama M, Bromberg S, Kwitek AE, Jacob HJ. The Rat Genome Database, update 2007--easing the path from disease to data and back again. Nucleic Acids Research. 35: D658-62. PMID 17151068 DOI: 10.1093/Nar/Gkl988  0.462
2007 Feroah TR, Forster HV, Merritt A, Dwinell M, Moreno‐Quinn C, Greene A, Jacob H, Kwitek A, Cowley A. Significant differences in novel and adapted circadian movement behavior in three parental and two ENU knockout inbred strains of rats The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A595-A  0.322
2006 Schlick NE, Jensen-Seaman MI, Orlebeke K, Kwitek AE, Jacob HJ, Lazar J. Sequence analysis of the complete mitochondrial DNA in 10 commonly used inbred rat strains. American Journal of Physiology. Cell Physiology. 291: C1183-92. PMID 16855218 DOI: 10.1152/Ajpcell.00234.2006  0.778
2006 Levan G, Jacob HJ. Nomenclature of the rat Cyp genes and the problems of gene nomenclature in general [Nelson, D.R. (2005), 'Gene nomenclature by default, or BLASTing to Babel', Hum. Genomics Vol. 2, pp. 196-201]. Human Genomics. 2: 343; author reply 34. PMID 16848971 DOI: 10.1186/1479-7364-2-6-343  0.382
2006 van Dijk SJ, Specht PA, Lazar J, Jacob HJ, Provoost AP. Absence of an interaction between the Rf-1 and Rf-5 QTLs influencing susceptibility to renal damage in rats. Nephron. Experimental Nephrology. 104: e96-e102. PMID 16837819 DOI: 10.1159/000094548  0.327
2006 Kunert MP, Drenjancevic-Peric I, Dwinell MR, Lombard JH, Cowley AW, Greene AS, Kwitek AE, Jacob HJ. Consomic strategies to localize genomic regions related to vascular reactivity in the Dahl salt-sensitive rat. Physiological Genomics. 26: 218-25. PMID 16772359 DOI: 10.1152/Physiolgenomics.00004.2006  0.498
2006 Dijk SJV, Specht PAC, Lazar J, Jacob HJ, Provoost AP. Synergistic QTL interactions between Rf-1 and Rf-3 increase renal damage susceptibility in double congenic rats Kidney International. 69: 1369-1376. PMID 16541022 DOI: 10.1038/Sj.Ki.5000301  0.365
2006 Kwitek AE, Jacob HJ, Baker JE, Dwinell MR, Forster HV, Greene AS, Kunert MP, Lombard JH, Mattson DL, Pritchard KA, Roman RJ, Tonellato PJ, Cowley AW. BN phenome: detailed characterization of the cardiovascular, renal, and pulmonary systems of the sequenced rat. Physiological Genomics. 25: 303-13. PMID 16478827 DOI: 10.1152/Physiolgenomics.00288.2005  0.454
2006 Malek RL, Wang HY, Kwitek AE, Greene AS, Bhagabati N, Borchardt G, Cahill L, Currier T, Frank B, Fu X, Hasinoff M, Howe E, Letwin N, Luu TV, Saeed A, ... ... Jacob HJ, et al. Physiogenomic resources for rat models of heart, lung and blood disorders. Nature Genetics. 38: 234-9. PMID 16415889 DOI: 10.1038/Ng1693  0.469
2006 Roman RJ, Hoagland KM, Lopez B, Kwitek AE, Garrett MR, Rapp JP, Lazar J, Jacob HJ, Sarkis A. Characterization of blood pressure and renal function in chromosome 5 congenic strains of Dahl S rats. American Journal of Physiology. Renal Physiology. 290: F1463-71. PMID 16396943 DOI: 10.1152/Ajprenal.00360.2005  0.439
2006 López B, Ryan RP, Moreno C, Sarkis A, Lazar J, Provoost AP, Jacob HJ, Roman RJ. Identification of a QTL on chromosome 1 for impaired autoregulation of RBF in fawn-hooded hypertensive rats. American Journal of Physiology. Renal Physiology. 290: F1213-21. PMID 16303858 DOI: 10.1152/Ajprenal.00335.2005  0.508
2006 Nicolantonio RD, Kostka V, Kwitek A, Jacob H, Thomas WG, Harrap SB. Fine mapping of Lvm1: a quantitative trait locus controlling heart size independently of blood pressure. Pulmonary Pharmacology & Therapeutics. 19: 70-73. PMID 16286240 DOI: 10.1016/J.Pupt.2005.02.010  0.482
2006 Lazar J, Moreno C, Jacob HJ, Kwitek AE. 14 Impact of Genomics on Research in the Rat Cold Spring Harbor Monograph Archive. 46: 281-311. DOI: 10.1101/087969807.46.281  0.497
2005 Shimoyama M, Petri V, Pasko D, Bromberg S, Wu W, Chen J, Nenasheva N, Kwitek A, Twigger S, Jacob H. Using Multiple Ontologies to Integrate Complex Biological Data Comparative and Functional Genomics. 6: 373-378. PMID 18629202 DOI: 10.1002/Cfg.498  0.353
2005 Lazar J, Moreno C, Jacob HJ, Kwitek AE. Impact of genomics on research in the rat. Genome Research. 15: 1717-28. PMID 16339370 DOI: 10.1101/Gr.3744005  0.436
2005 Van Dijk SJ, Specht PA, Lutz MM, Lazar J, Jacob HJ, Provoost AP. Interaction between Rf-1 and Rf-4 quantitative trait loci increases susceptibility to renal damage in double congenic rats. Kidney International. 68: 2462-72. PMID 16316323 DOI: 10.1111/J.1523-1755.2005.00722.X  0.409
2005 Twigger SN, Pasko D, Nie J, Shimoyama M, Bromberg S, Campbell D, Chen J, dela Cruz N, Fan C, Foote C, Harris G, Hickmann B, Ji Y, Jin W, Li D, ... ... Jacob HJ, et al. Tools and strategies for physiological genomics: the Rat Genome Database. Physiological Genomics. 23: 246-56. PMID 16106031 DOI: 10.1152/Physiolgenomics.00040.2005  0.414
2005 Moreno C, Kennedy K, Andrae JW, Jacob HJ. Genome-wide scanning with SSLPs in the rat. Methods in Molecular Medicine. 108: 131-8. PMID 16028680 DOI: 10.1385/1-59259-850-1:131  0.43
2005 Van Dijk SJ, Specht PA, Lazar J, Jacob HJ, Provoost AP. Renal damage susceptibility and autoregulation in RF-1 and RF-5 congenic rats. Nephron. Experimental Nephrology. 101: e59-66. PMID 15976509 DOI: 10.1159/000086417  0.417
2005 Rangel-Filho A, Sharma M, Datta YH, Moreno C, Roman RJ, Iwamoto Y, Provoost AP, Lazar J, Jacob HJ. RF-2 gene modulates proteinuria and albuminuria independently of changes in glomerular permeability in the fawn-hooded hypertensive rat. Journal of the American Society of Nephrology : Jasn. 16: 852-6. PMID 15758045 DOI: 10.1681/Asn.2005010029  0.45
2005 Dwinell MR, Forster HV, Petersen J, Rider A, Kunert MP, Cowley AW, Jacob HJ. Genetic determinants on rat chromosome 6 modulate variation in the hypercapnic ventilatory response using consomic strains. Journal of Applied Physiology (Bethesda, Md. : 1985). 98: 1630-8. PMID 15661838 DOI: 10.1152/Japplphysiol.01148.2004  0.449
2005 Mattson DL, Kunert MP, Roman RJ, Jacob HJ, Cowley AW. Substitution of chromosome 1 ameliorates L-NAME hypertension and renal disease in the fawn-hooded hypertensive rat. American Journal of Physiology. Renal Physiology. 288: F1015-22. PMID 15644486 DOI: 10.1152/Ajprenal.00374.2004  0.429
2005 Baessler A, Hasinoff MJ, Fischer M, Reinhard W, Sonnenberg GE, Olivier M, Erdmann J, Schunkert H, Doering A, Jacob HJ, Comuzzie AG, Kissebah AH, Kwitek AE. Genetic linkage and association of the growth hormone secretagogue receptor (ghrelin receptor) gene in human obesity. Diabetes. 54: 259-67. PMID 15616037 DOI: 10.2337/Diabetes.54.1.259  0.327
2005 de la Cruz N, Bromberg S, Pasko D, Shimoyama M, Twigger S, Chen J, Chen CF, Fan C, Foote C, Gopinath GR, Harris G, Hughes A, Ji Y, Jin W, Li D, ... ... Jacob H, et al. The Rat Genome Database (RGD): developments towards a phenome database. Nucleic Acids Research. 33: D485-91. PMID 15608243 DOI: 10.1093/Nar/Gki050  0.467
2004 Churchill GA, Airey DC, Allayee H, Angel JM, Attie AD, Beatty J, Beavis WD, Belknap JK, Bennett B, Berrettini W, Bleich A, Bogue M, Broman KW, Buck KJ, Buckler E, ... ... Jacob HJ, et al. The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nature Genetics. 36: 1133-7. PMID 15514660 DOI: 10.1038/Ng1104-1133  0.337
2004 Bilusic M, Bataillard A, Tschannen MR, Gao L, Barreto NE, Vincent M, Wang T, Jacob HJ, Sassard J, Kwitek AE. Mapping the genetic determinants of hypertension, metabolic diseases, and related phenotypes in the lyon hypertensive rat. Hypertension (Dallas, Tex. : 1979). 44: 695-701. PMID 15452030 DOI: 10.1161/01.Hyp.0000144542.57306.5E  0.476
2004 Michalkiewicz M, Michalkiewicz T, Ettinger RA, Rutledge EA, Fuller JM, Moralejo DH, Van Yserloo B, MacMurray AJ, Kwitek AE, Jacob HJ, Lander ES, Lernmark A. Transgenic rescue demonstrates involvement of the Ian5 gene in T cell development in the rat. Physiological Genomics. 19: 228-32. PMID 15328390 DOI: 10.1152/Physiolgenomics.00126.2004  0.567
2004 Cowley AW, Liang M, Roman RJ, Greene AS, Jacob HJ. Consomic rat model systems for physiological genomics. Acta Physiologica Scandinavica. 181: 585-92. PMID 15283774 DOI: 10.1111/J.1365-201X.2004.01334.X  0.474
2004 Kwitek AE, Gullings-Handley J, Yu J, Carlos DC, Orlebeke K, Nie J, Eckert J, Lemke A, Andrae JW, Bromberg S, Pasko D, Chen D, Scheetz TE, Casavant TL, Soares MB, ... ... Jacob HJ, et al. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Genome Research. 14: 750-7. PMID 15060019 DOI: 10.1101/Gr.1968704  0.462
2004 Twigger SN, Nie J, Ruotti V, Yu J, Chen D, Li D, Mathis J, Narayanasamy V, Gopinath GR, Pasko D, Shimoyama M, De La Cruz N, Bromberg S, Kwitek AE, Jacob HJ, et al. Integrative genomics: in silico coupling of rat physiology and complex traits with mouse and human data. Genome Research. 14: 651-60. PMID 15060006 DOI: 10.1101/Gr.1974504  0.481
2004 Vitt U, Gietzen D, Stevens K, Wingrove J, Becha S, Bulloch S, Burrill J, Chawla N, Chien J, Crawford M, Ison C, Kearney L, Kwong M, Park J, Policky J, ... ... Jacob H, et al. Identification of candidate disease genes by EST alignments, synteny, and expression and verification of Ensembl genes on rat chromosome 1q43-54. Genome Research. 14: 640-50. PMID 15060005 DOI: 10.1101/Gr.1932304  0.788
2004 Jensen-Seaman MI, Furey TS, Payseur BA, Lu Y, Roskin KM, Chen CF, Thomas MA, Haussler D, Jacob HJ. Comparative recombination rates in the rat, mouse, and human genomes. Genome Research. 14: 528-38. PMID 15059993 DOI: 10.1101/Gr.1970304  0.765
2004 Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, ... ... Jacob HJ, et al. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature. 428: 493-521. PMID 15057822 DOI: 10.1038/Nature02426  0.774
2004 Nobrega MA, Fleming S, Roman RJ, Shiozawa M, Schlick N, Lazar J, Jacob HJ. Initial characterization of a rat model of diabetic nephropathy. Diabetes. 53: 735-42. PMID 14988259 DOI: 10.2337/Diabetes.53.3.735  0.426
2004 Ueno T, Tremblay J, Kunes J, Zicha J, Dobesova Z, Pausova Z, Deng AY, Sun YL, Jacob HJ, Hamet P. Rat model of familial combined hyperlipidemia as a result of comparative mapping. Physiological Genomics. 17: 38-47. PMID 14709677 DOI: 10.1152/Physiolgenomics.00043.2003  0.47
2004 Cowley AW, Roman RJ, Jacob HJ. Application of chromosomal substitution techniques in gene-function discovery. The Journal of Physiology. 554: 46-55. PMID 14678490 DOI: 10.1113/Jphysiol.2003.052613  0.454
2004 Mattson DL, Kunert MP, Kaldunski ML, Greene AS, Roman RJ, Jacob HJ, Cowley AW. Influence of diet and genetics on hypertension and renal disease in Dahl salt-sensitive rats. Physiological Genomics. 16: 194-203. PMID 14600213 DOI: 10.1152/Physiolgenomics.00151.2003  0.425
2003 Cioffi JA, Erbe CB, Raphael R, Kwitek AE, Tiwari UK, Jacob HJ, Popper P, Wackym PA. Expression of G-protein alpha subunit genes in the vestibular periphery of Rattus norvegicus and their chromosomal mapping. Acta Oto-Laryngologica. 123: 1027-34. PMID 14710903 DOI: 10.1080/00016480310000773  0.352
2003 Moralejo DH, Park HA, Speros SJ, MacMurray AJ, Kwitek AE, Jacob HJ, Lander ES, Lernmark A. Genetic dissection of lymphopenia from autoimmunity by introgression of mutated Ian5 gene onto the F344 rat. Journal of Autoimmunity. 21: 315-24. PMID 14624755 DOI: 10.1016/S0896-8411(03)00138-0  0.515
2003 Moreno C, Dumas P, Kaldunski ML, Tonellato PJ, Greene AS, Roman RJ, Cheng Q, Wang Z, Jacob HJ, Cowley AW. Genomic map of cardiovascular phenotypes of hypertension in female Dahl S rats. Physiological Genomics. 15: 243-57. PMID 14532335 DOI: 10.1152/Physiolgenomics.00105.2003  0.471
2003 Datta YH, Wu FC, Dumas PC, Rangel-Filho A, Datta MW, Ning G, Cooley BC, Majewski RR, Provoost AP, Jacob HJ. Genetic mapping and characterization of the bleeding disorder in the fawn-hooded hypertensive rat. Thrombosis and Haemostasis. 89: 1031-42. PMID 12783116 DOI: 10.1055/S-0037-1613405  0.444
2003 Ueno T, Tremblay J, Kunes J, Zicha J, Dobesova Z, Pausova Z, Deng AY, Sun YL, Jacob HJ, Hamet P. Resolving the composite trait of hypertension into its pharmacogenetic determinants by acute pharmacological modulation of blood pressure regulatory systems. Journal of Molecular Medicine (Berlin, Germany). 81: 51-60. PMID 12545249 DOI: 10.1007/S00109-002-0394-7  0.396
2003 C.Wu F, Dumas P, Rangel-Filho A, Datta M, Ning G, Cooley B, Majewski R, Provoost A, Jacob H, Datta Y. Genetic mapping and characterization of the bleeding disorder in the fawn-hooded hypertensive rat Thrombosis and Haemostasis. 89: 1031-1042. DOI: 10.1055/S-0037-1613405  0.336
2002 Roman RJ, Cowley AW, Greene A, Kwitek AE, Tonellato PJ, Jacob HJ. Consomic rats for the identification of genes and pathways underlying cardiovascular disease. Cold Spring Harbor Symposia On Quantitative Biology. 67: 309-15. PMID 12858554 DOI: 10.1101/Sqb.2002.67.309  0.418
2002 Tseng J, Erbe CB, Kwitek AE, Jacob HJ, Popper P, Wackym PA. Radiation hybrid mapping of five muscarinic acetylcholine receptor subtype genes in Rattus norvegicus Hearing Research. 174: 86-92. PMID 12433399 DOI: 10.1016/S0378-5955(02)00641-X  0.404
2002 Kotchen TA, Broeckel U, Grim CE, Hamet P, Jacob H, Kaldunski ML, Kotchen JM, Schork NJ, Tonellato PJ, Cowley AW. Identification of hypertension-related QTLs in African American sib pairs. Hypertension. 40: 634-9. PMID 12411455 DOI: 10.1161/01.Hyp.0000036400.79248.22  0.385
2002 MacMurray AJ, Moralejo DH, Kwitek AE, Rutledge EA, Van Yserloo B, Gohlke P, Speros SJ, Snyder B, Schaefer J, Bieg S, Jiang J, Ettinger RA, Fuller J, Daniels TL, Pettersson A, ... ... Jacob HJ, et al. Lymphopenia in the BB rat model of type 1 diabetes is due to a mutation in a novel immune-associated nucleotide (Ian)-related gene. Genome Research. 12: 1029-39. PMID 12097339 DOI: 10.1101/Gr.412702  0.542
2002 Liang M, Yuan B, Rute E, Greene AS, Zou AP, Soares P, MCQuestion GD, Slocum GR, Jacob HJ, Cowley AW. Renal medullary genes in salt-sensitive hypertension: a chromosomal substitution and cDNA microarray study. Physiological Genomics. 8: 139-49. PMID 11875192 DOI: 10.1152/Physiolgenomics.00083.2001  0.456
2002 Provoost AP, Shiozawa M, Dokkum RPEV, Jacob HJ. Transfer of the Rf-1 region from FHH onto the ACI background increases susceptibility to renal impairment Physiological Genomics. 8: 123-129. PMID 11875190 DOI: 10.1152/Physiolgenomics.00030.2000  0.416
2002 Jacob HJ, Kwitek AE. Rat genetics: attaching physiology and pharmacology to the genome. Nature Reviews Genetics. 3: 33-42. PMID 11823789 DOI: 10.1038/Nrg702  0.496
2002 Broeckel U, Hengstenberg C, Mayer B, Holmer S, Martin LJ, Comuzzie AG, Blangero J, Nürnberg P, Reis A, Riegger GA, Jacob HJ, Schunkert H. A comprehensive linkage analysis for myocardial infarction and its related risk factors. Nature Genetics. 30: 210-4. PMID 11818963 DOI: 10.1038/Ng827  0.354
2002 Boerwinkle E, Brown CA, Carrejo M, Ferrell R, Hanis C, Hutchinson R, Kardia S, Sing C, Turner S, Weder A, Chakravarti A, Cooper R, Jacob H, NS, Hunt S, et al. Multi-center genetic study of hypertension: The Family blood pressure program (FBPP) Hypertension. 39: 3-9. PMID 11799070 DOI: 10.1161/Hy1201.100415  0.308
2002 Kita Y, Shiozawa M, Jin W, Majewski RR, Besharse JC, Greene AS, Jacob HJ. Implications of circadian gene expression in kidney, liver and the effects of fasting on pharmacogenomic studies. Pharmacogenetics. 12: 55-65. PMID 11773865 DOI: 10.1097/00008571-200201000-00008  0.352
2002 Twigger S, Lu J, Shimoyama M, Chen D, Pasko D, Long H, Ginster J, Chen CF, Nigam R, Kwitek A, Eppig J, Maltais L, Maglott D, Schuler G, Jacob H, et al. Rat Genome Database (RGD): mapping disease onto the genome. Nucleic Acids Research. 30: 125-8. PMID 11752273 DOI: 10.1093/Nar/30.1.125  0.518
2002 Yoon JW, Kita Y, Frank DJ, Majewski RR, Konicek BA, Nobrega MA, Jacob H, Walterhouse D, Iannaccone P. Gene expression profiling leads to identification of GLI1-binding elements in target genes and a role for multiple downstream pathways in GLI1-induced cell transformation. The Journal of Biological Chemistry. 277: 5548-55. PMID 11719506 DOI: 10.1074/Jbc.M105708200  0.301
2001 Stoll M, Cowley AW, Tonellato PJ, Greene AS, Kaldunski ML, Roman RJ, Dumas P, Schork NJ, Wang Z, Jacob HJ. A genomic-systems biology map for cardiovascular function. Science (New York, N.Y.). 294: 1723-6. PMID 11721057 DOI: 10.1126/Science.1062117  0.44
2001 Kwitek AE, Tonellato PJ, Chen D, Gullings-Handley J, Cheng YS, Twigger S, Scheetz TE, Casavant TL, Stoll M, Nobrega MA, Shiozawa M, Soares MB, Sheffield VC, Jacob HJ. Automated construction of high-density comparative maps between rat, human, and mouse Genome Research. 11: 1935-1943. PMID 11691858 DOI: 10.1101/Gr.173701  0.417
2001 Weksler-Zangen S, Yagil C, Zangen DH, Ornoy A, Jacob HJ, Yagil Y. The Newly Inbred Cohen Diabetic Rat: A Nonobese Normolipidemic Genetic Model of Diet-Induced Type 2 Diabetes Expressing Sex Differences Diabetes. 50: 2521-2529. PMID 11679430 DOI: 10.2337/Diabetes.50.11.2521  0.367
2001 Comuzzie AG, Funahashi T, Sonnenberg G, Martin LJ, Jacob HJ, Black AE, Maas D, Takahashi M, Kihara S, Tanaka S, Matsuzawa Y, Blangero J, Cohen D, Kissebah A. The genetic basis of plasma variation in adiponectin, a global endophenotype for obesity and the metabolic syndrome. The Journal of Clinical Endocrinology and Metabolism. 86: 4321-5. PMID 11549668 DOI: 10.1210/Jcem.86.9.7878  0.363
2001 Harris EL, Stoll M, Jones GT, Granados MA, Porteous WK, Van Rij AM, Jacob HJ. Identification of two susceptibility loci for vascular fragility in the Brown Norway rat. Physiological Genomics. 6: 183-9. PMID 11526202 DOI: 10.1152/Physiolgenomics.2001.6.3.183  0.387
2001 Stoll M, Jacob HJ. Genetic rat models of hypertension: relationship to human hypertension. Current Hypertension Reports. 3: 157-164. PMID 11276399 DOI: 10.1007/S11906-001-0031-9  0.459
2001 Nadeau JH, Balling R, Barsh G, Beier D, Brown SD, Bucan M, Camper S, Carlson G, Copeland N, Eppig J, Fletcher C, Frankel WN, Ganten D, Goldowitz D, Goodnow C, ... ... Jacob HJ, et al. Sequence interpretation. Functional annotation of mouse genome sequences. Science (New York, N.Y.). 291: 1251-5. PMID 11233449 DOI: 10.1126/Science.1058244  0.342
2001 Cowley AW, Roman RJ, Kaldunski ML, Dumas P, Dickhout JG, Greene AS, Jacob HJ. Brown Norway chromosome 13 confers protection from high salt to consomic Dahl S rat. Hypertension. 37: 456-61. PMID 11230318 DOI: 10.1161/01.Hyp.37.2.456  0.462
2001 Scheetz TE, Raymond MR, Nishimura DY, McClain A, Roberts C, Birkett C, Gardiner J, Zhang J, Butters N, Sun C, Kwitek-Black A, Jacob H, Casavant TL, Soares MB, Sheffield VC. Generation of a high-density rat EST map. Genome Research. 11: 497-502. PMID 11230173 DOI: 10.1101/Gr.151601  0.414
2001 Kwitek-Black AE, Jacob HJ. The use of designer rats in the genetic dissection of hypertension. Current Hypertension Reports. 3: 12-18. PMID 11177702 DOI: 10.1007/S11906-001-0072-0  0.508
2000 Kissebah AH, Sonnenberg GE, Myklebust J, Goldstein M, Broman K, James RG, Marks JA, Krakower GR, Jacob HJ, Weber J, Martin L, Blangero J, Comuzzie AG. Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome Proceedings of the National Academy of Sciences of the United States of America. 97: 14478-14483. PMID 11121050 DOI: 10.1073/Pnas.97.26.14478  0.354
2000 Gösele C, Hong L, Kreitler T, Rossmann M, Hieke B, Groß U, Kramer M, Himmelbauer H, Bihoreau MT, Kwitek-Black AE, Twigger S, Tonellato PJ, Jacob HJ, Schalkwyk LC, Lindpaintner K, et al. High-throughput scanning of the rat genome using interspersed repetitive sequence-PCR markers Genomics. 69: 287-294. PMID 11056046 DOI: 10.1006/Geno.2000.6352  0.487
2000 Cowley AW, Stoll M, Greene AS, Kaldunski ML, Roman RJ, Tonellato PJ, Schork NJ, Dumas P, Jacob HJ. Genetically defined risk of salt sensitivity in an intercross of Brown Norway and Dahl S rats. Physiological Genomics. 2: 107-15. PMID 11015589 DOI: 10.1152/Physiolgenomics.2000.2.3.107  0.486
2000 Zhu X, McKenzie CA, Forrester T, Nickerson DA, Broeckel U, Schunkert H, Doering A, Jacob HJ, Cooper RS, Rieder MJ. Localization of a small genomic region associated with elevated ACE. American Journal of Human Genetics. 67: 1144-53. PMID 11001581 DOI: 10.1016/S0002-9297(07)62945-0  0.38
2000 Dokkum RPEv, Jacob HJ, Provoost AP. Blood pressure and the susceptibility to renal damage after unilateral nephrectomy and L‐NAME‐induced hypertension in rats Nephrology Dialysis Transplantation. 15: 1337-1343. PMID 10978388 DOI: 10.1093/Ndt/15.9.1337  0.422
2000 Schork NJ, Chakravarti A, Thiel B, Fornage M, Jacob HJ, Cai R, Rotimi CN, Cooper RS, Weder AB. Lack of association between a biallelic polymorphism in the adducin gene and blood pressure in whites and African Americans. American Journal of Hypertension. 13: 693-8. PMID 10912755 DOI: 10.1016/S0895-7061(00)00237-5  0.326
2000 Stoll M, Kwitek-Black AE, Cowley AW, Harris EL, Harrap SB, Krieger JE, Printz MP, Provoost AP, Sassard J, Jacob HJ. New target regions for human hypertension via comparative genomics. Genome Research. 10: 473-82. PMID 10779487 DOI: 10.1101/Gr.10.4.473  0.428
2000 Jones GT, Harris EL, Jacob HJ, Rij AMv. Spontaneous Elastic Tissue Lesions in the Rat Abdominal Aorta, a Genetically Determined Phenotype Journal of Vascular Research. 37: 73-81. PMID 10754392 DOI: 10.1159/000025718  0.407
2000 Baker JE, Konorev EA, Gross GJ, Chilian WM, Jacob HJ. Resistance to myocardial ischemia in five rat strains: is there a genetic component of cardioprotection? American Journal of Physiology. Heart and Circulatory Physiology. 278: H1395-400. PMID 10749737 DOI: 10.1152/Ajpheart.2000.278.4.H1395  0.431
2000 Nobrega MA, Shiozawa M, Koike G, Jacob HJ, Miano JM. Gene structure and chromosomal mapping of the rat smooth muscle calponin gene. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 11: 115-9. PMID 10656925 DOI: 10.1007/S003350010023  0.46
2000 Fakhrai-Rad H, Jiao H, Li LS, Glaser A, Koike G, Jacob HJ, Luthman H, Galli J. A rat genetic linkage map including 67 new microsatellite markers. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 10: 1102-5. PMID 10556432 DOI: 10.1007/S003359901170  0.426
2000 Cowley AW, Roman RJ, Kaldunski ML, Tonellato PJ, Dumas P, Greene AS, Jacob HJ. Transfer of Brown Norway Rat Chromosome 13 into Dahl S Genomic Background Confers Protection from High Salt Diet Hypertension. 36: 717-717. DOI: 10.1161/01.Hyp.36.Suppl_1.717-A  0.483
2000 Hoagland KM, Alonso-Galicia M, Maier KG, Flasch AK, Wang X, Jacob HJ, Nobrega M, Rapp JP, Garrett MR, Roman RJ. Evaluation of P4504a Genes for Hypertension and Renal Disease Using Chromosome 5 Congenic Strains of Dahl S Rats. Hypertension. 36: 687-687. DOI: 10.1161/01.Hyp.36.Suppl_1.687-B  0.375
2000 Szpirer C, Szpirer J, Vanvooren P, Tissir F, Kela J, Lallemand F, Hoebee B, Simon JS, Koike G, Jacob HJ, Lander ES, Helou K, Klinga-Levan K, Levan G. The rat genetic and cytogenetic maps Journal of Experimental Animal Science. 41: 38-39. DOI: 10.1016/S0939-8600(00)80025-5  0.6
2000 Jacob HJ. Modern genetic mapping approaches in laboratory animals/rats Journal of Experimental Animal Science. 41: 32-34. DOI: 10.1016/S0939-8600(00)80023-1  0.432
1999 van Dokkum RPE, Sun CW, Provoost AP, Jacob HJ, Roman RJ. Altered renal hemodynamics and impaired myogenic responses in the fawn-hooded rat. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 276: R855-R863. PMID 29598711 DOI: 10.1152/Ajpregu.1999.276.3.R855  0.405
1999 Jacob HJ. Functional Genomics and Rat Models Genome Research. 9: 1013-1016. PMID 10568741 DOI: 10.1101/Gr.9.11.1013  0.467
1999 Glickman M, Malek RL, Kwitek-Black AE, Jacob HJ, Lee NH. Molecular cloning, tissue-specific expression, and chromosomal localization of a novel nerve growth factor-regulated G-protein- coupled receptor, nrg-1. Molecular and Cellular Neurosciences. 14: 141-52. PMID 10532805 DOI: 10.1006/Mcne.1999.0776  0.324
1999 Klaff LS, Koike G, Jiang J, Wang Y, Bieg S, Pettersson A, Lander E, Jacob H, Lernmark Å. BB rat diabetes susceptibility and body weight regulation genes colocalize on Chromosome 2 Mammalian Genome. 10: 883-887. PMID 10441739 DOI: 10.1007/S003359901108  0.52
1999 Jacob HJ. Physiological genetics: application to hypertension research. Clinical and Experimental Pharmacology and Physiology. 26: 530-535. PMID 10405781 DOI: 10.1046/J.1440-1681.1999.03078.X  0.46
1999 Shimoda N, Knapik EW, Ziniti J, Sim C, Yamada E, Kaplan S, Jackson D, de Sauvage F, Jacob H, Fishman MC. Zebrafish genetic map with 2000 microsatellite markers. Genomics. 58: 219-32. PMID 10373319 DOI: 10.1006/Geno.1999.5824  0.345
1999 Szpirer C, Szpirer J, Van Vooren P, Tissir F, Simon JS, Koike G, Jacob HJ, Lander ES, Helou K, Klinga-Levan K, Levan G. Gene-based anchoring of the rat genetic linkage and cytogenetic maps. Transplantation Proceedings. 31: 1541-3. PMID 10330994 DOI: 10.1016/S0041-1345(99)00030-5  0.595
1999 Wei S, Wei K, Moralejo DH, Ogino T, Koike G, Jacob HJ, Sugiura K, Sasaki Y, Yamada T, Matsumoto K. Mapping and characterization of quantitative trait loci for non-insulin-dependent diabetes mellitus with an improved genetic map in the Otsuka Long-Evans Tokushima fatty rat. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 10: 249-58. PMID 10051320 DOI: 10.1007/S003359900982  0.414
1999 Koike G, Chiche JD, Shiozawa M, Simon JS, Szpirer J, Jacob HJ, Szpirer C, Bloch KD. Localization of rat genes in the nitric oxide signaling pathway: candidates for the pathogenesis of complex diseases. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 10: 71-3. PMID 9892738 DOI: 10.1007/S003359900946  0.356
1999 Dokkum RPEV, Alonso-Galicia M, Provoost AP, Jacob HJ, Roman RJ. Impaired autoregulation of renal blood flow in the fawn-hooded rat American Journal of Physiology-Regulatory Integrative and Comparative Physiology. 276. PMID 9887194 DOI: 10.1152/Ajpregu.1999.276.1.R189  0.378
1999 Szpirer C, Szpirer J, Van Vooren P, Tissir F, Simon JS, Koike G, Jacob HJ, Lander ES, Helou K, Klinga-Levan K, Levan G. Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 9: 721-34. PMID 9716657 DOI: 10.1007/S003359900853  0.591
1999 Steen RG, Kwitek-Black AE, Glenn C, Gullings-Handley J, Etten WV, Atkinson OS, Appel D, Twigger S, Muir M, Mull T, Granados M, Kissebah M, Russo K, Crane R, Popp M, ... ... Jacob HJ, et al. A high-density integrated genetic linkage and radiation hybrid map of the laboratory rat. Genome Research. 9. DOI: 10.1101/Gr.9.6.Ap1  0.443
1999 Knoblauch M, Jacob H, Ganten D, Lindpaintner K. Report on rat chromosome 10 Journal of Experimental Animal Science. 40: 81-92. DOI: 10.1016/S0939-8600(99)80011-X  0.416
1998 Brown DM, Matise TC, Koike G, Simon JS, Winer ES, Zangen S, McLaughlin MG, Shiozawa M, Atkinson OS, Hudson JR, Chakravarti A, Lander ES, Jacob HJ. An integrated genetic linkage map of the laboratory rat. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 9: 521-30. PMID 9657848 DOI: 10.1007/S003359900812  0.571
1998 Brown DM, Van Dokkum RP, Korte MR, McLauglin MG, Shiozawa M, Jacob HJ, Provoost AP. Genetic control of susceptibility for renal damage in hypertensive fawn-hooded rats. Renal Failure. 20: 407-11. PMID 9574469 DOI: 10.3109/08860229809045128  0.422
1998 Broeckel U, Shiozawa M, Kissebah AH, Provoost AP, Jacob HJ. Susceptibility genes for end-organ damage. New strategies to understand diabetic and hypertensive nephropathy. Nephrology Dialysis Transplantation. 13: 840-842. PMID 9568834 DOI: 10.1093/Ndt/13.4.840  0.303
1998 Knapik EW, Goodman A, Ekker M, Chevrette M, Delgado J, Neuhauss S, Shimoda N, Driever W, Fishman MC, Jacob HJ. A microsatellite genetic linkage map for zebrafish (Danio rerio). Nature Genetics. 18: 338-43. PMID 9537415 DOI: 10.1038/Ng0498-338  0.392
1998 Bieg S, Koike G, Jiang J, Klaff L, Pettersson A, MacMurray AJ, Jacob HJ, Lander ES, Lernmark A. Genetic isolation of iddm 1 on chromosome 4 in the biobreeding (BB) rat. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 9: 324-6. PMID 9530633 DOI: 10.1007/S003359900759  0.587
1998 Jiang J, Jacob HJ. EbEST: An Automated Tool Using Expressed Sequence Tags to Delineate Gene Structure Genome Research. 8: 268-275. PMID 9521930 DOI: 10.1101/Gr.8.3.268  0.35
1998 Innes BA, McLaughlin MG, Kapuscinski MK, Jacob HJ, Harrap SB. Independent Genetic Susceptibility to Cardiac Hypertrophy in Inherited Hypertension Hypertension. 31: 741-746. PMID 9495256 DOI: 10.1161/01.Hyp.31.3.741  0.448
1998 Koike G, Miano JM, Vanvooren P, Shiozawa M, Szpirer C, Jacob HJ. Mapping of the rat SM22 gene to chromosome 8q24: a candidate for high blood pressure and cardiac hypertrophy. Mammalian Genome. 9: 76-77. PMID 9434951 DOI: 10.1007/S003359900684  0.416
1998 Provoost AP, Shiozawa M, Majewski RR, Dokkum RPEV, Jacob HJ. Genetic analysis of the susceptibility to develop renal damage after unilateral nephrectomy in rats American Journal of Hypertension. 11. DOI: 10.1016/S0895-7061(97)90720-2  0.416
1998 VanDokkum RPE, Provoost AP, Jacob HJ, Roman RJ. Intraglomerular hypertension and hyperfiltration due to impaired renal autoregulation in the fawn-hooded hypertensive (FHH) rat American Journal of Hypertension. 11. DOI: 10.1016/S0895-7061(97)90707-X  0.379
1997 Dokkum RPEv, Jacob HJ, Provoost AP. Difference in Susceptibility of Developing Renal Damage in Normotensive Fawn-Hooded (FHL) and August × Copenhagen Irish (ACI) Rats After Nω-Nitro-l-arginine Methyl Ester Induced Hypertension American Journal of Hypertension. 10: 1109-1116. PMID 9370381 DOI: 10.1016/S0895-7061(97)00163-5  0.42
1997 Harris EL, Grigor MR, Innes BA, Harrap SB, Koike G, Jacob HJ. Strain-specific deletions in exon 10 of rat K-kininogen and T1-kininogen genes allow mapping of both genes to rat chromosome 11. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 8: 791-2. PMID 9321484 DOI: 10.1007/S003359900574  0.456
1997 Zhang QY, Dene H, Deng AY, Garrett MR, Jacob HJ, Rapp JP. Interval mapping and congenic strains for a blood pressure QTL on rat chromosome 13. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 8: 636-41. PMID 9271663 DOI: 10.1007/S003359900528  0.435
1997 Szpirer C, Szpirer J, Vanvooren P, Rivière M, Maget B, Svoboda M, Shiozawa M, Simon JS, Jacob HJ, Koike G. Localization of the rat genes encoding glucagon, glucagon receptor, and insulin receptor, candidates for diabetes mellitus susceptibility loci. Mammalian Genome. 8: 586-588. PMID 9250867 DOI: 10.1007/S003359900510  0.33
1997 Stelzner T, Hofmann TA, Brown D, Deng A, Jacob HJ. Genetic Determinants of Pulmonary Hypertension in Fawn-Hooded Rats Chest. 111. PMID 9184548 DOI: 10.1378/Chest.111.6_Supplement.96S  0.407
1997 Jiang J, Stec DE, Drummond H, Simon JS, Koike G, Jacob HJ, Roman RJ. Transfer of a salt-resistant renin allele raises blood pressure in Dahl salt-sensitive rats. Hypertension. 29: 619-627. PMID 9040448 DOI: 10.1161/01.Hyp.29.2.619  0.367
1997 Koike G, Van Vooren P, Shiozawa M, Galli J, Li LS, Glaser A, Balasubramanyam A, Brown LJ, Luthman H, Szpirer C, MacDonald MJ, Jacob HJ. Genetic mapping and chromosome localization of the rat mitochondrial glycerol-3-phosphate dehydrogenase gene, a candidate for non-insulin-dependent diabetes mellitus. Genomics. 38: 96-9. PMID 8954787 DOI: 10.1006/Geno.1996.0599  0.477
1997 Otsen M, den Bieman M, Kuiper MT, Pravenec M, Kren V, Kurtz TW, Jacob HJ, Lankhorst A, van Zutphen BF. Use of AFLP markers for gene mapping and QTL detection in the rat. Genomics. 37: 289-94. PMID 8938440 DOI: 10.1006/Geno.1996.0562  0.408
1997 Satler CA, Walsh EP, Vesely MR, Plummer MH, Ginsburg GS, Jacob HJ. Novel missense mutation in the cyclic nucleotide-binding domain of HERG causes long QT syndrome. American Journal of Medical Genetics. 65: 27-35. PMID 8914737 DOI: 10.1002/(Sici)1096-8628(19961002)65:1<27::Aid-Ajmg4>3.0.Co;2-V  0.334
1997 Jacob H. Genetics of ESRD: Of rat and man? American Journal of Hypertension. 10. DOI: 10.1016/S0895-7061(97)89443-5  0.447
1997 Provoost AP, Dokkum RPEv, Jacob HJ. A1 Genetic factors rather than blood pressure determine the development of proteinuria after unilateral nephrectomy (UNX) in rats American Journal of Hypertension. 10. DOI: 10.1016/S0895-7061(97)88748-1  0.375
1997 Dokkum RPEv, Jacob HJ, Provoost AP. L-name-induced hypertension reveals genetic differences in susceptibility to renal damage American Journal of Hypertension. 10. DOI: 10.1016/S0895-7061(97)88687-6  0.329
1996 Larsson M, Tissir F, Walter L, Günther E, Jacob H, Klinga-Levan K, Levan G. Mapping of the rat ribosomal protein S18 gene (Rps 18) to Chromosome 20p12 Mammalian Genome. 7: 90-90. PMID 8903742 DOI: 10.1007/S003359900024  0.408
1996 Jacob HJ. A landmark for orphan genomes Nature Genetics. 13: 14-15. PMID 8673094 DOI: 10.1038/Ng0596-14  0.327
1996 Stec DE, Trolliet MR, Krieger JE, Jacob HJ, Roman RJ. Renal cytochrome P4504A activity and salt sensitivity in spontaneously hypertensive rats. Hypertension (Dallas, Tex. : 1979). 27: 1329-36. PMID 8641744 DOI: 10.1161/01.Hyp.27.6.1329  0.412
1996 St Lezin EM, Pravenec M, Wong AL, Liu W, Wang N, Lu S, Jacob HJ, Roman RJ, Stec DE, Wang JM, Reid IA, Kurtz TW. Effects of renin gene transfer on blood pressure and renin gene expression in a congenic strain of Dahl salt-resistant rats. The Journal of Clinical Investigation. 97: 522-7. PMID 8567976 DOI: 10.1172/Jci118444  0.46
1996 Brown DM, Provoost AP, Daly MJ, Lander ES, Jacob HJ. Renal disease susceptibility and hypertension are under independent genetic control in the fawn-hooded rat. Nature Genetics. 12: 44-51. PMID 8528250 DOI: 10.1038/Ng0196-44  0.636
1996 Galli J, Li LS, Glaser A, Ostenson CG, Jiao H, Fakhrai-Rad H, Jacob HJ, Lander ES, Luthman H. Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat. Nature Genetics. 12: 31-7. PMID 8528247 DOI: 10.1038/Ng0196-31  0.542
1995 Schork NJ, Krieger JE, Trolliet MR, Franchini KG, Koike G, Krieger EM, Lander ES, Dzau VJ, Jacob HJ. A biometrical genome search in rats reveals the multigenic basis of blood pressure variation Genome Research. 5: 164-172. PMID 9132270 DOI: 10.1101/Gr.5.2.164  0.56
1995 Jacob HJ, Ramanthan A, Pan SG, Brody MJ, Myers GA. Spectral analysis of arterial pressure lability in rats with sinoaortic deafferentation. The American Journal of Physiology. 269: R1481-8. PMID 8594953 DOI: 10.1152/Ajpregu.1995.269.6.R1481  0.378
1995 Pettersson A, Winer ES, Weksler-Zangen S, Lernmark A, Jacob HJ. Predictability of heterozygosity scores and polymorphism information content values for rat genetic markers. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 6: 512-20. PMID 8589519 DOI: 10.1007/Bf00356167  0.429
1995 Otsen M, Den Bieman M, Winer ES, Jacob HJ, Szpirer J, Szpirer C, Bender K, Van Zutphen LF. Use of simple sequence length polymorphisms for genetic characterization of rat inbred strains. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 6: 595-601. PMID 8535065 DOI: 10.1007/Bf00352364  0.398
1995 Tay A, Simon JS, Squire J, Hamel K, Jacob HJ, Skorecki K. Cytosolic phospholipase A2 gene in human and rat: chromosomal localization and polymorphic markers. Genomics. 26: 138-41. PMID 7782073 DOI: 10.1016/0888-7543(95)80093-2  0.453
1995 Truett GE, Jacob HJ, Miller J, Drouin G, Bahary N, Smoller JW, Lander ES, Leibel RL. Genetic map of rat Chromosome 5 including the fatty (fa) locus Mammalian Genome. 6: 25-30. PMID 7719022 DOI: 10.1007/Bf00350889  0.501
1995 Jacob HJ, Brown DM, Bunker RK, Daly MJ, Dzau VJ, Goodman A, Koike G, Kren V, Kurtz T, Lernmark A, Levan G, Mao YP, Pettersson A, Pravenec M, Simon JS, et al. A genetic linkage map of the laboratory rat, Rattus norvegicus Nature Genetics. 9: 63-69. PMID 7704027 DOI: 10.1038/Ng0195-63  0.594
1995 Koike G, Jacob HJ, Krieger JE, Szpirer C, Hoehe MR, Horiuchi M, Dzau VJ. Investigation of the phenylethanolamine N-methyltransferase gene as a candidate gene for hypertension. Hypertension (Dallas, Tex. : 1979). 26: 595-601. PMID 7558218 DOI: 10.1161/01.Hyp.26.4.595  0.503
1995 Bloch KD, Wolfram JR, Brown DM, Roberts JD, Zapol DG, Lepore JJ, Filippov G, Thomas JE, Jacob HJ, Bloch DB. Three members of the nitric oxide synthase II gene family (NOS2A, NOS2B, and NOS2C) colocalize to human chromosome 17. Genomics. 27: 526-30. PMID 7558036 DOI: 10.1006/Geno.1995.1086  0.35
1995 Pettersson A, Wilson D, Daniels T, Tobin S, Jacob HJ, Lander ES, Lernmark A. Thyroiditis in the BB rat is associated with lymphopenia but occurs independently of diabetes. Journal of Autoimmunity. 8: 493-505. PMID 7492346 DOI: 10.1016/0896-8411(95)90004-7  0.513
1995 Koike G, Winer ES, Horiuchi M, Brown DM, Szpirer C, Dzau VJ, Jacob HJ. Cloning, characterization, and genetic mapping of the rat type 2 angiotensin II receptor gene. Hypertension. 26: 998-1002. PMID 7490161 DOI: 10.1161/01.Hyp.26.6.998  0.442
1995 JACOB H. Hypertension associated renal failure in the fawn-hooded rat is the result of a genetic predisposition American Journal of Hypertension. 8: 24A. DOI: 10.1016/0895-7061(95)97463-2  0.409
1994 Koike G, Krieger JE, Jacob HJ, Mukoyama M, Pratt RE, Dzau VJ. Angiotensin converting enzyme and genetic hypertension: cloning of rat cDNAs and characterization of the enzyme. Biochemical and Biophysical Research Communications. 198: 380-6. PMID 8292044 DOI: 10.1006/Bbrc.1994.1053  0.435
1994 Koike G, Horiuchi M, Yamada T, Szpirer C, Jacob HJ, Dzau VJ. Human Type 2 Angiotensin II Receptor Gene: Cloned, Mapped to the X Chromosome, and Its mRNA Is Expressed in the Human Lung Biochemical and Biophysical Research Communications. 203: 1842-1850. PMID 7945336 DOI: 10.1006/Bbrc.1994.2402  0.364
1994 Jacob HJ, Pettersson A, Wilson D, Mao Y, Lernmark Å, Lander ES. Erratum: Corrigendum: Genetic dissection of autoimmune type I diabetes in the BB rat Nature Genetics. 7: 215-215. DOI: 10.1038/Ng0694-215A  0.379
1993 Jacob HJ, Pettersson A, Wilson D, Mao Y, Lernmark A, Lander ES. Genetic dissection of autoimmune type I diabetes in the BB rat. Nature Genetics. 2: 56-60. PMID 1303251 DOI: 10.1038/Ng0992-56  0.586
1992 Dzau VJ, Jacob HJ, Lindpainter K, Ganten D, Lander ES. Genetic mapping in hypertension. Journal of Vascular Surgery. 15: 930. PMID 1578573 DOI: 10.1016/0741-5214(92)90757-Y  0.518
1992 Barres C, Lewis SJ, Jacob HJ, Brody MJ. Arterial pressure lability and renal sympathetic nerve activity are dissociated in SAD rats. The American Journal of Physiology. 263: R639-46. PMID 1415652 DOI: 10.1152/Ajpregu.1992.263.3.R639  0.386
1992 Kimura S, Mullins JJ, Bunnemann B, Metzger R, Hilgenfeldt U, Zimmermann F, Jacob H, Fuxe K, Ganten D, Kaling M. High blood pressure in transgenic mice carrying the rat angiotensinogen gene. The Embo Journal. 11: 821-827. DOI: 10.1002/J.1460-2075.1992.Tb05119.X  0.359
1991 Jacob HJ, Sigmund CD, Shockley TR, Gross KW, Dzau VJ. Renin promoter SV40 T-antigen transgenic mouse: A model of primary renal vascular hyperplasia Hypertension. 17: 1167-1172. PMID 2045162 DOI: 10.1161/01.Hyp.17.6.1167  0.3
1989 Lewis SJ, Barres C, Jacob HJ, Ohta H, Brody MJ. Cardiovascular effects of the N-methyl-D-aspartate receptor antagonist MK-801 in conscious rats. Hypertension. 13: 759-65. PMID 2544522 DOI: 10.1161/01.Hyp.13.6.759  0.361
1988 Jacob HJ, Barres CP, Machado BH, Brody MJ. Studies on neural and humoral contributions to arterial pressure lability. The American Journal of the Medical Sciences. 295: 341-5. PMID 3284353 DOI: 10.1097/00000441-198804000-00021  0.361
1987 Alper RH, Jacob HJ, Brody MJ. Regulation of arterial pressure lability in rats with chronic sinoaortic deafferentation. The American Journal of Physiology. 253: H466-74. PMID 3618819 DOI: 10.1152/Ajpheart.1987.253.2.H466  0.417
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