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Marcos M. Sotomayor - Publications

Affiliations: 
Chemistry and Biochemistry Ohio State University, Columbus, Columbus, OH 
Area:
Mechanotransduction - Cellular Adhesion - Structural Biology - Molecular Dynamics Simulations - Protein Biochemistry and Biophysics
Website:
http://chemistry.osu.edu/faculty/sotomayor
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71 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Zheng W, Rawson S, Shen Z, Tamilselvan E, Smith HE, Halford J, Shen C, Murthy SE, Ulbrich MH, Sotomayor M, Fu TM, Holt JR. TMEM63 proteins function as monomeric high-threshold mechanosensitive ion channels. Neuron. PMID 37543036 DOI: 10.1016/j.neuron.2023.07.006  0.625
2023 Giese APJ, Weng WH, Kindt KS, Chang HHV, Montgomery JS, Ratzan EM, Beirl AJ, Rivera RA, Lotthammer JM, Walujkar S, Foster MP, Zobeiri OA, Holt JR, Riazuddin S, Cullen KE, ... Sotomayor M, et al. Complexes of vertebrate TMC1/2 and CIB2/3 proteins form hair-cell mechanotransduction cation channels. Biorxiv : the Preprint Server For Biology. PMID 37398045 DOI: 10.1101/2023.05.26.542533  0.669
2023 Ivanchenko MV, Hathaway DM, Klein AJ, Pan B, Strelkova O, De-la-Torre P, Wu X, Peters CW, Mulhall EM, Booth KT, Goldstein C, Brower J, Sotomayor M, Indzhykulian AA, Corey DP. Mini-PCDH15 gene therapy rescues hearing in a mouse model of Usher syndrome type 1F. Nature Communications. 14: 2400. PMID 37100771 DOI: 10.1038/s41467-023-38038-y  0.757
2023 Nisler CR, Narui Y, Scheib E, Choudhary D, Bowman JD, Mandayam Bharathi H, Lynch VJ, Sotomayor M. Interpreting the Evolutionary Echoes of a Protein Complex Essential for Inner-Ear Mechanosensation. Molecular Biology and Evolution. 40. PMID 36911992 DOI: 10.1093/molbev/msad057  0.308
2022 Neel BL, Nisler CR, Walujkar S, Araya-Secchi R, Sotomayor M. Elastic versus Brittle Mechanical Responses Predicted for Dimeric Cadherin Complexes. Biophysical Journal. PMID 35151631 DOI: 10.1016/j.bpj.2022.02.007  0.342
2021 Gray ME, Johnson ZR, Modak D, Tamilselvan E, Tyska MJ, Sotomayor M. Heterophilic and homophilic cadherin interactions in intestinal intermicrovillar links are species dependent. Plos Biology. 19: e3001463. PMID 34871294 DOI: 10.1371/journal.pbio.3001463  0.309
2021 Ahmed T, Nisler CR, Fluck EC, Walujkar S, Sotomayor M, Moiseenkova-Bell VY. Structure of the ancient TRPY1 channel from Saccharomyces cerevisiae reveals mechanisms of modulation by lipids and calcium. Structure (London, England : 1993). PMID 34453887 DOI: 10.1016/j.str.2021.08.003  0.343
2021 Gray ME, Sotomayor M. Crystal structure of the nonclassical cadherin-17 N-terminus and implications for its adhesive binding mechanism. Acta Crystallographica. Section F, Structural Biology Communications. 77: 85-94. PMID 33682793 DOI: 10.1107/S2053230X21002247  0.307
2020 Choudhary D, Narui Y, Neel BL, Wimalasena LN, Klanseck CF, De-la-Torre P, Chen C, Araya-Secchi R, Tamilselvan E, Sotomayor M. Structural determinants of protocadherin-15 mechanics and function in hearing and balance perception. Proceedings of the National Academy of Sciences of the United States of America. PMID 32963095 DOI: 10.1073/pnas.1920444117  0.783
2020 Tamilselvan E, Sotomayor MM. Elucidating the Adhesive Mechanism of the Atypical Cadherin CELSR1 Involved in Planar Cell Polarity Biophysical Journal. 118. DOI: 10.1016/J.Bpj.2019.11.677  0.332
2020 Choudhary D, Narui Y, Neel B, Walujkar S, Lotthammer JM, Sudar JC, Nisler C, Wimalasena LN, Klanseck CF, De-la-Torre P, Chen C, Araya-Secchi RR, Tamilselvan E, Sotomayor M. Structuring Inner-ear Mechanotransduction Biophysical Journal. 118. DOI: 10.1016/J.Bpj.2019.11.255  0.337
2020 Lotthammer J, Walujkar S, Wimalasena LN, Sotomayor MM. In-Silico Electrophysiology of Inner-Ear Mechanotransduction Channel Models Biophysical Journal. 118. DOI: 10.1016/J.Bpj.2019.11.1582  0.378
2020 Nisler C, Narui Y, Lynch V, Sotomayor MM. The Evolutionary Biophysics of A Force-Conveying Protein Complex Required for Vertebrate Hearing Biophysical Journal. 118. DOI: 10.1016/J.Bpj.2019.11.1044  0.349
2019 Nicoludis JM, Green AG, Walujkar S, May EJ, Sotomayor M, Marks DS, Gaudet R. Interaction specificity of clustered protocadherins inferred from sequence covariation and structural analysis. Proceedings of the National Academy of Sciences of the United States of America. PMID 31431536 DOI: 10.1073/Pnas.1821063116  0.613
2019 Park MS, Araya-Secchi R, Brackbill JA, Phan HD, Kehling AC, Abd El-Wahab EW, Dayeh DM, Sotomayor M, Nakanishi K. Multidomain Convergence of Argonaute during RISC Assembly Correlates with the Formation of Internal Water Clusters. Molecular Cell. PMID 31324450 DOI: 10.1016/J.Molcel.2019.06.011  0.352
2019 Neel BL, Klanseck CF, Sotomayor M. Structure of a Non-Canonical and Flexible Middle Domain in Inner-Ear Protocadherin-15 Biophysical Journal. 116: 48a. DOI: 10.1016/J.Bpj.2018.11.302  0.359
2019 Pan B, Akyuz N, Liu X, Asai Y, Nist-Lund C, Kurima K, Derfler B, György B, Limapichat W, Walujkar S, Wimalasena L, Sotomayor M, Corey D, Holt JR. Cysteine Substitution Reveals the Pore-Forming Region of TMC1 in Hair Cell Sensory Transduction Channels Biophysical Journal. 116: 460a. DOI: 10.1016/J.Bpj.2018.11.2486  0.784
2019 De-la-Torre P, Narui Y, Choudhary D, Araya-Secchi R, Sotomayor M. Structures and Simulations of Membrane Adjacent Fragments of Protocadherin-15 Biophysical Journal. 116. DOI: 10.1016/J.Bpj.2018.11.2480  0.329
2019 Choudhary D, Narui Y, Neel BL, Wimalasena LN, Klanseck CF, Chen C, De-la-Torre P, Araya-Secchi R, Tamilselvan E, Sotomayor M. Structure and In Silico Elasticity of a Complete Protocadherin-15 Dimer Biophysical Journal. 116: 427a. DOI: 10.1016/J.Bpj.2018.11.2299  0.34
2019 Walujkar S, Wimalasena LN, Lotthammer J, Sotomayor M. Molecular Dynamics Simulations of TMC1 Homology Models Biophysical Journal. 116. DOI: 10.1016/J.Bpj.2018.11.1320  0.317
2018 De-la-Torre P, Choudhary D, Araya-Secchi R, Narui Y, Sotomayor M. A Mechanically Weak Extracellular Membrane-Adjacent Domain Induces Dimerization of Protocadherin-15. Biophysical Journal. 115: 2368-2385. PMID 30527337 DOI: 10.1016/J.Bpj.2018.11.010  0.774
2018 Chen TH, Sotomayor M, Gopalan V. Biochemical Studies Provide Insights into the Necessity for MultipleArabidopsis thalianaProtein-Only RNase P Isoenzymes. Journal of Molecular Biology. PMID 30414965 DOI: 10.1016/J.Jmb.2018.11.004  0.367
2018 Pan B, Akyuz N, Liu XP, Asai Y, Nist-Lund C, Kurima K, Derfler BH, György B, Limapichat W, Walujkar S, Wimalasena LN, Sotomayor M, Corey DP, Holt JR. TMC1 Forms the Pore of Mechanosensory Transduction Channels in Vertebrate Inner Ear Hair Cells. Neuron. 99: 736-753.e6. PMID 30138589 DOI: 10.1016/J.Neuron.2018.07.033  0.805
2018 Jaiganesh A, De-la-Torre P, Patel AA, Termine DJ, Velez-Cortes F, Chen C, Sotomayor M. Zooming in on Cadherin-23: Structural Diversity and Potential Mechanisms of Inherited Deafness. Structure (London, England : 1993). PMID 30033219 DOI: 10.1016/J.Str.2018.06.003  0.761
2018 Narui Y, Sotomayor M. Tuning Inner-Ear Tip-Link Affinity Through Alternatively Spliced Variants of Protocadherin-15 Biochemistry. 57: 1702-1710. PMID 29443515 DOI: 10.1021/Acs.Biochem.7B01075  0.438
2018 Jaiganesh A, Narui Y, Araya-Secchi R, Sotomayor M. Beyond Cell-Cell Adhesion: Sensational Cadherins for Hearing and Balance. Cold Spring Harbor Perspectives in Biology. 10. PMID 28847902 DOI: 10.1101/Cshperspect.A029280  0.497
2017 Choudhary D, Kumar A, Magliery TJ, Sotomayor M. Using thermal scanning assays to test protein-protein interactions of inner-ear cadherins. Plos One. 12: e0189546. PMID 29261728 DOI: 10.1371/Journal.Pone.0189546  0.399
2017 Powers RE, Gaudet R, Sotomayor M. A Partial Calcium-Free Linker Confers Flexibility to Inner-Ear Protocadherin-15. Structure (London, England : 1993). PMID 28238533 DOI: 10.1016/J.Str.2017.01.014  0.646
2017 Jaiganesh A, Patel A, De-la-Torre P, Termine D, Velez-Cortes F, Sotomayor M. Towards a Complete Structural Model for the Essential Inner-Ear Protein Cadherin-23 Biophysical Journal. 112: 535a. DOI: 10.1016/J.Bpj.2016.11.2892  0.386
2017 Walujkar SP, Araya-Sechhi R, Sotomayor M. Simulated Forced Unbinding of Clustered Protocadherins Biophysical Journal. 112: 449. DOI: 10.1016/J.Bpj.2016.11.2406  0.366
2017 Neel B, Nisler C, Araya-Secchi R, Sotomayor M. Large Scale Molecular Dynamics Simulations of Three Classical Cadherins Involved in Cell Adhesion Biophysical Journal. 112. DOI: 10.1016/J.Bpj.2016.11.1748  0.449
2016 Araya-Secchi R, Neel BL, Sotomayor M. An elastic element in the protocadherin-15 tip link of the inner ear. Nature Communications. 7: 13458. PMID 27857071 DOI: 10.1038/Ncomms13458  0.467
2016 Cooper SR, Jontes JD, Sotomayor M. Structural determinants of adhesion by Protocadherin-19 and implications for its role in epilepsy. Elife. 5. PMID 27787195 DOI: 10.7554/Elife.18529  0.354
2016 Narui Y, Velez-Cortes F, Johnson Z, Sotomayor M. Steered Molecular Dynamics Simulations of Inner-Ear Cadherins using the Drude Polarizable Force Field Biophysical Journal. 110: 177. DOI: 10.1016/J.Bpj.2015.11.988  0.4
2016 Sotomayor M, Araya-Secchi R, Narui Y, Chen C, Klanseck C, Wimalasena L. Structural Determinants of Protocadherin-15 Function in Inner-Ear Mechanotransduction Biophysical Journal. 110: 93a. DOI: 10.1016/J.Bpj.2015.11.563  0.528
2016 Choudhary D, Kumar A, Magliery TJ, Sotomayor M. Using Inner-Ear Cadherins to Test High-Throughput Thermal Screening Assays for Protein-Protein Interactions Biophysical Journal. 110: 388a-389a. DOI: 10.1016/J.Bpj.2015.11.2100  0.35
2016 Thornburg A, Sotomayor M. Resolving the Molecular Mechanisms of Inherited Deafness caused by Missense Mutations in Cadherin-23 Biophysical Journal. 110: 319a. DOI: 10.1016/J.Bpj.2015.11.1714  0.442
2016 Jaiganesh A, Kilic D, Patel A, Termine D, Velez-Cortes F, Irfan Kufrevioglu O, Sotomayor M. Structure and Stability of Tip Link Cadherin-23 Fragments Involved in Hearing and Deafness Biophysical Journal. 110: 209a. DOI: 10.1016/J.Bpj.2015.11.1162  0.435
2016 Koussa MA, Ward A, Sotomayor M, Wong WP, Corey DP. Single Molecule Force Spectroscopy of Hair-Cell Tip-Link Proteins Biophysical Journal. 110: 196a. DOI: 10.1016/J.Bpj.2015.11.1090  0.802
2015 Narui Y, Sotomayor M. Structural and Biophysical Characterization of Inner Ear Tip Link Variants Biophysical Journal. 108: 562a. DOI: 10.1016/J.Bpj.2014.11.3078  0.516
2015 Araya-Secchi R, Sotomayor M. Structure of an Inner-Ear Protocadherin-15 Fragment with an Atypical Calcium-Free Linker Biophysical Journal. 108: 561a. DOI: 10.1016/J.Bpj.2014.11.3075  0.427
2015 Powers RE, Gaudet R, Sotomayor M. Structural Study of a Novel Partial Calcium-Free Linker and a Positively Selected Variation in Protocadherin-15: Implications for Hearing and Cell Adhesion Biophysical Journal. 108: 505a. DOI: 10.1016/J.Bpj.2014.11.2765  0.655
2015 Sotomayor M. Mechanisms and Mechanosensitivity: Exceptional Cadherins for Hearing and Balance Biophysical Journal. 108: 11a-12a. DOI: 10.1016/J.Bpj.2014.11.089  0.542
2014 Sotomayor M, Gaudet R, Corey DP. Sorting out a promiscuous superfamily: towards cadherin connectomics. Trends in Cell Biology. 24: 524-36. PMID 24794279 DOI: 10.1016/J.Tcb.2014.03.007  0.781
2014 Koussa MA, Sotomayor M, Wong WP. Protocol for sortase-mediated construction of DNA-protein hybrids and functional nanostructures. Methods (San Diego, Calif.). 67: 134-41. PMID 24568941 DOI: 10.1016/J.Ymeth.2014.02.020  0.772
2014 Sotomayor M, Gaudet R, Corey DP. Molecular Mechanisms of Deafness Mutations Disrupting Tip-Link Function in Hair-Cell Mechanotransduction Biophysical Journal. 106: 449a. DOI: 10.1016/J.Bpj.2013.11.2546  0.812
2014 Koussa MA, Sotomayor M, Wong WP, Corey DP. Force Spectroscopy of Tip Link Proteins: A Study of Inner-Ear Biophysics Biophysical Journal. 106: 386a. DOI: 10.1016/J.Bpj.2013.11.2183  0.8
2013 Geng R, Sotomayor M, Kinder KJ, Gopal SR, Gerka-Stuyt J, Chen DH, Hardisty-Hughes RE, Ball G, Parker A, Gaudet R, Furness D, Brown SD, Corey DP, Alagramam KN. Noddy, a mouse harboring a missense mutation in protocadherin-15, reveals the impact of disrupting a critical interaction site between tip-link cadherins in inner ear hair cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 4395-404. PMID 23467356 DOI: 10.1523/Jneurosci.4514-12.2013  0.792
2013 Sotomayor M, Weihofen WA, Gaudet R, Corey DP. Structures and Simulated Dynamics of a Force-Conveying Cadherin Bond Essential for Inner-Ear Mechanotransduction Biophysical Journal. 104: 166a. DOI: 10.1016/J.Bpj.2012.11.937  0.82
2012 Sotomayor M, Weihofen WA, Gaudet R, Corey DP. Structure of a force-conveying cadherin bond essential for inner-ear mechanotransduction. Nature. 492: 128-32. PMID 23135401 DOI: 10.1038/Nature11590  0.822
2012 Inada H, Procko E, Sotomayor M, Gaudet R. Structural and biochemical consequences of disease-causing mutations in the ankyrin repeat domain of the human TRPV4 channel. Biochemistry. 51: 6195-206. PMID 22702953 DOI: 10.1021/Bi300279B  0.789
2012 Gumbart J, Khalili-Araghi F, Sotomayor M, Roux B. Constant electric field simulations of the membrane potential illustrated with simple systems. Biochimica Et Biophysica Acta. 1818: 294-302. PMID 22001851 DOI: 10.1016/J.Bbamem.2011.09.030  0.753
2011 Gamini R, Sotomayor M, Chipot C, Schulten K. Cytoplasmic domain filter function in the mechanosensitive channel of small conductance. Biophysical Journal. 101: 80-9. PMID 21723817 DOI: 10.1016/J.Bpj.2011.05.042  0.802
2011 Sotomayor M, Weihofen WA, Gaudet R, Corey DP. Molecular mechanics of tip-link cadherins Aip Conference Proceedings. 1403: 64-69. DOI: 10.1063/1.3658062  0.752
2011 Naranjo D, Valencia I, Moscoso C, Stack K, Márquez V, Vergara A, Sotomayor M, González-Nilo F. Ion Conduction in a Shaker Potassium Channel Mutant Having an Unusually High Single Channel Conductance Biophysical Journal. 100: 564a-565a. DOI: 10.1016/J.Bpj.2010.12.3275  0.378
2010 Sotomayor M, Weihofen WA, Gaudet R, Corey DP. Structural determinants of cadherin-23 function in hearing and deafness. Neuron. 66: 85-100. PMID 20399731 DOI: 10.1016/J.Neuron.2010.03.028  0.806
2010 Gamini R, Sotomayor M, Chipot C, Schulten K. The Role of MscS Cytoplasmic Domain As An Osmolyte Filter Biophysical Journal. 98: 328a. DOI: 10.1016/J.Bpj.2009.12.1778  0.796
2009 Lee EH, Hsin J, Sotomayor M, Comellas G, Schulten K. Discovery through the computational microscope. Structure (London, England : 1993). 17: 1295-306. PMID 19836330 DOI: 10.1016/J.Str.2009.09.001  0.504
2009 Khalili-Araghi F, Gumbart J, Wen PC, Sotomayor M, Tajkhorshid E, Schulten K. Molecular dynamics simulations of membrane channels and transporters. Current Opinion in Structural Biology. 19: 128-37. PMID 19345092 DOI: 10.1016/J.Sbi.2009.02.011  0.798
2009 Sotomayor M, Corey DP. Calcium Dependent Dynamics and Forced Unbinding of Cadherins Biophysical Journal. 96: 642a-643a. DOI: 10.1016/J.Bpj.2008.12.3399  0.739
2008 Vásquez V, Sotomayor M, Cordero-Morales J, Schulten K, Perozo E. A structural mechanism for MscS gating in lipid bilayers. Science (New York, N.Y.). 321: 1210-4. PMID 18755978 DOI: 10.1126/Science.1159674  0.54
2008 Vásquez V, Sotomayor M, Cortes DM, Roux B, Schulten K, Perozo E. Three-dimensional architecture of membrane-embedded MscS in the closed conformation. Journal of Molecular Biology. 378: 55-70. PMID 18343404 DOI: 10.1016/J.Jmb.2007.10.086  0.556
2008 Sotomayor M, Schulten K. The allosteric role of the Ca2+ switch in adhesion and elasticity of C-cadherin Biophysical Journal. 94: 4621-4633. PMID 18326636 DOI: 10.1529/Biophysj.107.125591  0.587
2008 Lim BB, Lee EH, Sotomayor M, Schulten K. Molecular basis of fibrin clot elasticity. Structure (London, England : 1993). 16: 449-59. PMID 18294856 DOI: 10.1016/J.Str.2007.12.019  0.515
2007 Sotomayor M, Schulten K. Single-molecule experiments in vitro and in silico Science. 316: 1144-1148. PMID 17525328 DOI: 10.1126/Science.1137591  0.571
2007 Sotomayor M, Vásquez V, Perozo E, Schulten K. Ion conduction through MscS as determined by electrophysiology and simulation. Biophysical Journal. 92: 886-902. PMID 17114233 DOI: 10.1529/Biophysj.106.095232  0.547
2006 Gao M, Sotomayor M, Villa E, Lee EH, Schulten K. Molecular mechanisms of cellular mechanics. Physical Chemistry Chemical Physics : Pccp. 8: 3692-706. PMID 16896432 DOI: 10.1039/B606019F  0.731
2006 Sotomayor M, Van Der Straaten TA, Ravaioli U, Schulten K. Electrostatic properties of the mechanosensitive channel of small conductance MscS Biophysical Journal. 90: 3496-3510. PMID 16513774 DOI: 10.1529/Biophysj.105.080069  0.577
2005 Sotomayor M, Corey DP, Schulten K. In search of the hair-cell gating spring elastic properties of ankyrin and cadherin repeats. Structure (London, England : 1993). 13: 669-82. PMID 15837205 DOI: 10.1016/J.Str.2005.03.001  0.792
2004 Sotomayor M, Schulten K. Molecular dynamics study of gating in the mechanosensitive channel of small conductance MscS Biophysical Journal. 87: 3050-3065. PMID 15339798 DOI: 10.1529/Biophysj.104.046045  0.595
2004 Corey DP, Sotomayor M. Hearing: tightrope act. Nature. 428: 901-3. PMID 15118709 DOI: 10.1038/428901A  0.707
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