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David A. Spiegel, Ph.D., MD - Publications

Affiliations: 
2007- Chemistry Yale University, New Haven, CT 
Area:
natural product synthesis
Website:
http://www.chem.yale.edu/faculty/spiegel.html
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44 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Caianiello DF, Zhang M, Ray JD, Howell RA, Swartzel JC, Branham EMJ, Chirkin E, Sabbasani VR, Gong AZ, McDonald DM, Muthusamy V, Spiegel DA. Bifunctional small molecules that mediate the degradation of extracellular proteins. Nature Chemical Biology. PMID 34413525 DOI: 10.1038/s41589-021-00851-1  0.405
2021 Douglass EF, Spiegel DA. Comment on a suite of mathematical solutions to describe ternary complex formation and their application to targeted protein degradation by heterobifunctional ligands. The Journal of Biological Chemistry. 296: 100331. PMID 33837728 DOI: 10.1016/j.jbc.2021.100331  0.752
2020 Baumann T, Dunkel A, Schmid C, Schmitt S, Hiltensperger M, Lohr K, Laketa V, Donakonda S, Ahting U, Lorenz-Depiereux B, Heil JE, Schredelseker J, Simeoni L, Fecher C, Körber N, ... ... Spiegel D, et al. Regulatory myeloid cells paralyze T cells through cell-cell transfer of the metabolite methylglyoxal. Nature Immunology. 21: 555-566. PMID 32327756 DOI: 10.1038/S41590-020-0666-9  0.608
2019 De Coen R, Nuhn L, Perera C, Arista-Romero M, Risseeuw MDP, Freyn A, Nachbagauer R, Albertazzi L, Van Calenbergh S, Spiegel DA, Peterson BR, De Geest BG. A synthetic rhamnose glycopolymer cell surface receptor for endogenous antibody recruitment. Biomacromolecules. PMID 31829561 DOI: 10.1021/Acs.Biomac.9B01483  0.301
2019 Sabbasani VR, Wang KP, Streeter MD, Spiegel DA. One-Step Synthesis of 2,5-Diaminoimidazoles and Total Synthesis of Methylglyoxal-Derived Imidazolium Crosslink (MODIC). Angewandte Chemie (International Ed. in English). PMID 31713976 DOI: 10.1002/Anie.201911156  0.598
2018 Galligan JJ, Wepy JA, Streeter MD, Kingsley PJ, Mitchener MM, Wauchope OR, Beavers WN, Rose KL, Wang T, Spiegel DA, Marnett LJ. Methylglyoxal-derived posttranslational arginine modifications are abundant histone marks. Proceedings of the National Academy of Sciences of the United States of America. PMID 30150385 DOI: 10.1073/pnas.1802901115  0.58
2017 Leung JC, Bedermann AA, Njardarson JT, Spiegel DA, Murphy GK, Hama N, Twenter BM, Dong P, Shirahata T, McDonald IM, Inoue M, Taniguchi N, McMahon TC, Schneider CM, Tao N, et al. Total Synthesis of (±)-Phomoidride D. Angewandte Chemie (International Ed. in English). PMID 29286556 DOI: 10.1002/Anie.201712369  0.749
2017 Chirkin E, Muthusamy V, Mann P, Roemer T, Nantermet PG, Spiegel D. Neutralization of pathogenic fungi with small-molecule immunotherapeutics. Angewandte Chemie (International Ed. in English). PMID 28793176 DOI: 10.1002/Anie.201707536  0.518
2017 Sankaranarayanan S, Jamshed M, Kumar A, Skori L, Scandola S, Wang T, Spiegel D, Samuel MA. Glyoxalase Goes Green: The Expanding Roles of Glyoxalase in Plants. International Journal of Molecular Sciences. 18. PMID 28441779 DOI: 10.3390/Ijms18040898  0.584
2017 Vastl J, Wang T, Trinh TB, Spiegel DA. Encoded Silicon-Chip-Based Platform for Combinatorial Synthesis and Screening. Acs Combinatorial Science. PMID 28263558 DOI: 10.1021/Acscombsci.6B00181  0.689
2016 Vastl J, Kartika R, Park K, Cho AE, Spiegel DA. Peptidines: glycine-amidine-based oligomers for solution- and solid-phase synthesis. Chemical Science. 7: 3317-3324. PMID 29997824 DOI: 10.1039/C5Sc03882K  0.667
2016 Rullo AF, Fitzgerald KJ, Muthusamy V, Liu M, Yuan C, Huang M, Kim M, Cho AE, Spiegel DA. Re-engineering the Immune Response to Metastatic Cancer: Antibody-Recruiting Small Molecules Targeting the Urokinase Receptor. Angewandte Chemie (International Ed. in English). PMID 26879524 DOI: 10.1002/Anie.201510866  0.736
2015 Draghici C, Wang T, Spiegel DA. Concise total synthesis of glucosepane. Science (New York, N.Y.). 350: 294-8. PMID 26472902 DOI: 10.1126/Science.Aac9655  0.705
2015 Gautam S, Kim T, Shoda T, Sen S, Deep D, Luthra R, Ferreira MT, Pinho MG, Spiegel DA. An Activity-Based Probe for Studying Crosslinking in Live Bacteria. Angewandte Chemie (International Ed. in English). PMID 26204841 DOI: 10.1002/Anie.201503869  0.524
2015 Dafre AL, Goldenberg J, Wang T, Spiegel DA, Maher P. Methylglyoxal, the foe and friend of glyoxalase and Trx/TrxR systems in HT22 nerve cells. Free Radical Biology & Medicine. PMID 26165190 DOI: 10.1016/J.Freeradbiomed.2015.07.005  0.593
2015 Wang T, Streeter MD, Spiegel DA. Generation and characterization of antibodies against arginine-derived advanced glycation endproducts. Bioorganic & Medicinal Chemistry Letters. PMID 26117561 DOI: 10.1016/J.Bmcl.2015.06.013  0.608
2015 Kamen C, Mustian KM, Heckler C, Janelsins MC, Peppone LJ, Mohile S, McMahon JM, Lord R, Flynn PJ, Weiss M, Spiegel D, Morrow GR. The association between partner support and psychological distress among prostate cancer survivors in a nationwide study. Journal of Cancer Survivorship : Research and Practice. PMID 25603949 DOI: 10.1007/S11764-015-0425-3  0.487
2015 Galligan JJ, Mitchener M, Wang T, Wauchope O, Rose K, Spiegel D, Marnett L. Histones Are Major Targets for Modification by Glucose-Derived Methylglyoxal Free Radical Biology and Medicine. 87: S24. DOI: 10.1016/J.Freeradbiomed.2015.10.066  0.573
2014 McEnaney PJ, Fitzgerald KJ, Zhang AX, Douglass EF, Shan W, Balog A, Kolesnikova MD, Spiegel DA. Chemically synthesized molecules with the targeting and effector functions of antibodies. Journal of the American Chemical Society. 136: 18034-43. PMID 25514603 DOI: 10.1021/Ja509513C  0.769
2014 Parker CG, Dahlgren MK, Tao RN, Li DT, Douglass EF, Shoda T, Jawanda N, Spasov KA, Lee S, Zhou N, Domaoal RA, Sutton RE, Anderson KS, Jorgensen WL, Krystal M, ... Spiegel DA, et al. Illuminating HIV gp120-Ligand Recognition through Computationally-Driven Optimization of Antibody-Recruiting Molecules. Chemical Science (Royal Society of Chemistry : 2010). 5: 2311-2317. PMID 25379167 DOI: 10.1039/C4Sc00484A  0.757
2013 Jakobsche CE, Parker CG, Tao RN, Kolesnikova MD, Douglass EF, Spiegel DA. Exploring binding and effector functions of natural human antibodies using synthetic immunomodulators. Acs Chemical Biology. 8: 2404-11. PMID 24053626 DOI: 10.1021/Cb4004942  0.768
2013 Wang T, Douglass EF, Fitzgerald KJ, Spiegel DA. A "turn-on" fluorescent sensor for methylglyoxal. Journal of the American Chemical Society. 135: 12429-33. PMID 23931147 DOI: 10.1021/Ja406077J  0.755
2013 Douglass EF, Miller CJ, Sparer G, Shapiro H, Spiegel DA. A comprehensive mathematical model for three-body binding equilibria. Journal of the American Chemical Society. 135: 6092-9. PMID 23544844 DOI: 10.1021/Ja311795D  0.759
2013 Murphy GK, Shirahata T, Hama N, Bedermann A, Dong P, McMahon TC, Twenter BM, Spiegel DA, McDonald IM, Taniguchi N, Inoue M, Wood JL. Toward the synthesis of phomoidride D. The Journal of Organic Chemistry. 78: 477-89. PMID 23245580 DOI: 10.1021/Jo302353G  0.749
2012 Murphy GK, Hama N, Bedermann A, Dong P, Schneider CM, McMahon TC, Tao RN, Twenter BM, Spiegel DA, Wood JL. Wharton-fragmentation-based approach to the carbocyclic core of the phomoidrides. Organic Letters. 14: 4544-7. PMID 22917221 DOI: 10.1021/Ol302011B  0.752
2012 McEnaney PJ, Parker CG, Zhang AX, Spiegel DA. Antibody-recruiting molecules: an emerging paradigm for engaging immune function in treating human disease. Acs Chemical Biology. 7: 1139-51. PMID 22758917 DOI: 10.1021/Cb300119G  0.777
2012 Wang T, Kartika R, Spiegel DA. Exploring post-translational arginine modification using chemically synthesized methylglyoxal hydroimidazolones. Journal of the American Chemical Society. 134: 8958-67. PMID 22591136 DOI: 10.1021/Ja301994D  0.757
2012 Spiegel D. Mind matters in cancer survival Psycho-Oncology. 21: 588-593. PMID 22438289 DOI: 10.1002/Pon.3067  0.304
2012 Jakobsche CE, McEnaney PJ, Zhang AX, Spiegel DA. Reprogramming urokinase into an antibody-recruiting anticancer agent. Acs Chemical Biology. 7: 316-21. PMID 22098560 DOI: 10.1021/cb200374e  0.785
2012 Zhang AX, Hoimes CJ, Murelli RP, Saltzman WM, Spiegel DA. Abstract 4747: Redirecting the endogenous immune response against prostate cancer using an antibody-recruiting small molecule Cancer Research. 72: 4747-4747. DOI: 10.1158/1538-7445.Am2012-4747  0.715
2011 Nelson JW, Chamessian AG, McEnaney PJ, Murelli RP, Kazmierczak BI, Spiegel DA. Correction to A Biosynthetic Strategy for Re-engineering the Staphylococcus aureus Cell Wall with Non-native Small Molecules Acs Chemical Biology. 6: 971-971. DOI: 10.1021/Cb200283S  0.75
2010 Nelson JW, Chamessian AG, McEnaney PJ, Murelli RP, Kazmierczak BI, Kazmiercak BI, Spiegel DA. A biosynthetic strategy for re-engineering the Staphylococcus aureus cell wall with non-native small molecules. Acs Chemical Biology. 5: 1147-55. PMID 20923200 DOI: 10.1021/Cb100195D  0.756
2010 Zhang AX, Murelli RP, Barinka C, Michel J, Cocleaza A, Jorgensen WL, Lubkowski J, Spiegel DA. A remote arene-binding site on prostate specific membrane antigen revealed by antibody-recruiting small molecules. Journal of the American Chemical Society. 132: 12711-6. PMID 20726553 DOI: 10.1021/Ja104591M  0.711
2010 Hoimes CJ, Murelli RP, Kelly WK, Zhang AX, Cheng CJ, Fields RJ, Spiegel DA, Saltzman WM. Effect of vorinostat (V)-loaded PLGA nanoparticles (NP) surface modified with a PSMA ligand on prostate cancer (PC) cells. Journal of Clinical Oncology. 28: e13629-e13629. DOI: 10.1200/Jco.2010.28.15_Suppl.E13629  0.68
2009 Stern E, Jay SM, Demento SL, Murelli RP, Reed MA, Malinski T, Spiegel DA, Mooney DJ, Fahmy TM. Spatiotemporal control over molecular delivery and cellular encapsulation from electropolymerized micro- and nanopatterned surfaces. Advanced Functional Materials. 19: 2888-2895. PMID 20445826 DOI: 10.1002/Adfm.200900307  0.62
2009 Murelli RP, Zhang AX, Michel J, Jorgensen WL, Spiegel DA. Chemical control over immune recognition: a class of antibody-recruiting small molecules that target prostate cancer. Journal of the American Chemical Society. 131: 17090-2. PMID 19888723 DOI: 10.1021/Ja906844E  0.722
2009 Parker CG, Domaoal RA, Anderson KS, Spiegel DA. An antibody-recruiting small molecule that targets HIV gp120. Journal of the American Chemical Society. 131: 16392-4. PMID 19839582 DOI: 10.1021/Ja9057647  0.591
2009 Stern E, Jay SM, Demento SL, Murelli RP, Reed MA, Malinski T, Spiegel DA, Mooney DJ, Fahmy TM. Surface Patterning: Spatiotemporal Control over Molecular Delivery and Cellular Encapsulation from Electropolymerized Micro- and Nanopatterned Surfaces(Adv. Funct. Mater. 18/2009) Advanced Functional Materials. 19: NA-NA. DOI: 10.1002/Adfm.200990084  0.598
2007 Medeiros MR, Schacherer LN, Spiegel DA, Wood JL. Expanding the scope of trialkylborane/water-mediated radical reactions. Organic Letters. 9: 4427-9. PMID 17900194 DOI: 10.1021/Ol7016609  0.753
2006 Spiegel DA, Schroeder FC, Duvall JR, Schreiber SL. An oligomer-based approach to skeletal diversity in small-molecule synthesis. Journal of the American Chemical Society. 128: 14766-7. PMID 17105261 DOI: 10.1021/Ja065724A  0.559
2005 Spiegel DA, Wiberg KB, Schacherer LN, Medeiros MR, Wood JL. Deoxygenation of alcohols employing water as the hydrogen atom source. Journal of the American Chemical Society. 127: 12513-5. PMID 16144398 DOI: 10.1021/Ja052185L  0.759
2003 Spiegel DA, Njardarson JT, McDonald IM, Wood JL. The art of innovation in organic chemistry: synthetic efforts toward the phomoidrides. Chemical Reviews. 103: 2691-727. PMID 12848583 DOI: 10.1021/Cr020408+  0.752
2002 Spiegel DA, Njardarson JT, Wood JL. CP-263,114 synthetic studies. Construction of an isotwistane ring system via rhodium carbenoid C-H insertion Tetrahedron. 58: 6545-6554. DOI: 10.1016/S0040-4020(02)00664-6  0.706
2001 Njardarson JT, McDonald IM, Spiegel DA, Inoue M, Wood JL. An expeditious approach toward the total synthesis of CP-263,114. Organic Letters. 3: 2435-8. PMID 11483028 DOI: 10.1021/Ol015979N  0.779
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