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Tom Brown - Publications

Affiliations: 
University of Oxford, Oxford, United Kingdom 
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312 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Bai C, Klimkowski P, Jin C, Kuchlyan J, El-Sagheer AH, Brown T. A new phosphoramidite enables orthogonal double labelling to form combination oligonucleotide probes. Organic & Biomolecular Chemistry. PMID 36314563 DOI: 10.1039/d2ob01899c  0.352
2022 McGorman B, Fantoni NZ, O'Carroll S, Ziemele A, El-Sagheer AH, Brown T, Kellett A. Enzymatic Synthesis of Chemical Nuclease Triplex-Forming Oligonucleotides with Gene-Silencing Applications. Nucleic Acids Research. 50: 5467-5481. PMID 35640595 DOI: 10.1093/nar/gkac438  0.344
2021 Gorman J, Orsborne SRE, Sridhar A, Pandya R, Budden P, Ohmann A, Panjwani NA, Liu Y, Greenfield JL, Dowland S, Gray V, Ryan STJ, De Ornellas S, El-Sagheer AH, Brown T, et al. Deoxyribonucleic Acid Encoded and Size-Defined π-Stacking of Perylene Diimides. Journal of the American Chemical Society. PMID 34936763 DOI: 10.1021/jacs.1c10241  0.305
2021 De Fazio AF, Misatziou D, Baker YR, Muskens OL, Brown T, Kanaras AG. Chemically modified nucleic acids and DNA intercalators as tools for nanoparticle assembly. Chemical Society Reviews. 50: 13410-13440. PMID 34792047 DOI: 10.1039/d1cs00632k  0.319
2021 Epple S, Modi A, Baker YR, Wȩgrzyn E, Traoré D, Wanat P, Tyburn AES, Shivalingam A, Taemaitree L, El-Sagheer AH, Brown T. A New 1,5-Disubstituted Triazole DNA Backbone Mimic with Enhanced Polymerase Compatibility. Journal of the American Chemical Society. 143: 16293-16301. PMID 34546729 DOI: 10.1021/jacs.1c08057  0.343
2021 Baker YR, Yuan L, Chen J, Belle R, Carlisle R, El-Sagheer AH, Brown T. Expanding the chemical functionality of DNA nanomaterials generated by rolling circle amplification. Nucleic Acids Research. PMID 34403467 DOI: 10.1093/nar/gkab720  0.336
2021 Nordén B, Brown T, Feng B. Mismatch detection in homologous strand exchange amplified by hydrophobic effects. Biopolymers. e23426. PMID 33780001 DOI: 10.1002/bip.23426  0.382
2021 Taemaitree L, Shivalingam A, El-Sagheer AH, Brown T. "Split-and-Click" sgRNA. Methods in Molecular Biology (Clifton, N.J.). 2162: 61-78. PMID 32926378 DOI: 10.1007/978-1-0716-0687-2_5  0.384
2020 Gill MR, Walker MG, Able S, Tietz O, Lakshminarayanan A, Anderson R, Chalk R, El-Sagheer AH, Brown T, Thomas JA, Vallis KA. An In-labelled bis-ruthenium(ii) dipyridophenazine theranostic complex: mismatch DNA binding and selective radiotoxicity towards MMR-deficient cancer cells. Chemical Science. 11: 8936-8944. PMID 33815738 DOI: 10.1039/D0Sc02825H  0.412
2020 Baranda Pellejero L, Mahdifar M, Ercolani G, Watson J, Brown T, Ricci F. Using antibodies to control DNA-templated chemical reactions. Nature Communications. 11: 6242. PMID 33288745 DOI: 10.1038/s41467-020-20024-3  0.309
2020 Fantoni N, McGorman B, Molphy Z, Singleton D, Walsh S, El-Sagheer AH, McKee V, Brown T, Kellett A. Development of Gene-Targeted Polypyridyl Triplex Forming Oligonucleotide Hybrids. Chembiochem : a European Journal of Chemical Biology. PMID 32755000 DOI: 10.1002/Cbic.202000408  0.449
2020 Wypijewska Del Nogal A, Füchtbauer AF, Bood M, Nilsson JR, Wranne MS, Sarangamath S, Pfeiffer P, Rajan VS, El-Sagheer AH, Dahlén A, Brown T, Grøtli M, Wilhelmsson LM. Getting DNA and RNA out of the dark with 2CNqA: a bright adenine analogue and interbase FRET donor. Nucleic Acids Research. PMID 32558908 DOI: 10.1093/Nar/Gkaa525  0.475
2020 Goodchild SA, Gao R, Shenton DP, McIntosh AJS, Brown T, Bartlett PN. Direct Detection and Discrimination of Nucleotide Polymorphisms Using Anthraquinone Labeled DNA Probes. Frontiers in Chemistry. 8: 381. PMID 32478035 DOI: 10.3389/Fchem.2020.00381  0.46
2020 Shivalingam A, Taemaitree L, El-Sagheer AH, Brown T. Squaramides and Ureas: A Flexible Approach to Polymerase-Compatible Nucleic Acid Assembly. Angewandte Chemie (International Ed. in English). PMID 32153132 DOI: 10.1002/Anie.202000209  0.437
2020 Hardwick JS, Haugland MM, El-Sagheer AH, Ptchelkine D, Beierlein FR, Lane AN, Brown T, Lovett JE, Anderson EA. 2'-Alkynyl spin-labelling is a minimally perturbing tool for DNA structural analysis. Nucleic Acids Research. PMID 32052020 DOI: 10.1093/Nar/Gkaa086  0.784
2020 Füchtbauer AF, Wranne MS, Sarangamath S, Bood M, El-Sagheer AH, Brown T, Gradén H, Grøtli M, Wilhelmsson LM. Lighting Up DNA with the Environment-Sensitive Bright Adenine Analogue qAN4. Chempluschem. 85: 319-326. PMID 32045137 DOI: 10.1002/Cplu.201900712  0.476
2020 Sayoh I, Rusling DA, Brown T, Fox KR. DNA Structural Changes Induced by Intermolecular Triple Helix Formation. Acs Omega. 5: 1679-1687. PMID 32010842 DOI: 10.1021/acsomega.9b03776  0.344
2020 Paoletti F, El-Sagheer AH, Allard J, Brown T, Dushek O, Esashi F. Molecular flexibility of DNA as a key determinant of RAD51 recruitment. The Embo Journal. e103002. PMID 31943278 DOI: 10.15252/Embj.2019103002  0.465
2020 Oliveira LM, Long AS, Brown T, Fox KR, Weber G. Melting temperature measurement and mesoscopic evaluation of single, double and triple DNA mismatches Chemical Science. 11: 8273-8287. DOI: 10.1039/D0Sc01700K  0.406
2020 Baker YR, Traoré D, Wanat P, Tyburn A, El-Sagheer AH, Brown T. Searching for the ideal triazole: Investigating the 1,5-triazole as a charge neutral DNA backbone mimic Tetrahedron. 76: 130914. DOI: 10.1016/J.Tet.2019.130914  0.467
2019 Carter MLJ, Rusling DA, Gurr S, Brown T, Fox KR. Stability of the different arms of a DNA tetrahedron and its interaction with a minor groove ligand. Biophysical Chemistry. 256: 106270. PMID 31706136 DOI: 10.1016/J.Bpc.2019.106270  0.429
2019 Panattoni A, El-Sagheer AH, Brown T, Kellett A, Hocek M. Oxidative DNA Cleavage with Clip-Phenanthroline Triplex Forming Oligonucleotide Hybrids. Chembiochem : a European Journal of Chemical Biology. PMID 31680391 DOI: 10.1002/Cbic.201900670  0.403
2019 Thomas AM, Brolih S, McGouran JF, El-Sagheer AH, Ptchelkine D, Jones M, McDonald NQ, McHugh PJ, Brown T. Optimised oligonucleotide substrates to assay XPF-ERCC1 nuclease activity for the discovery of DNA repair inhibitors. Chemical Communications (Cambridge, England). PMID 31497827 DOI: 10.1039/C9Cc05476F  0.38
2019 Doherty W, Dürr EM, Baddock HT, Lee SY, McHugh PJ, Brown T, Senge MO, Scanlan EM, McGouran JF. A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A. Organic & Biomolecular Chemistry. PMID 31380542 DOI: 10.1039/C9Ob01133A  0.383
2019 Jackson MR, Bavelaar BM, Waghorn PA, Gill MR, El-Sagheer AH, Brown T, Tarsounas M, Vallis KA. Radiolabeled oligonucleotides targeting the RNA subunit of telomerase inhibit telomerase and induce DNA damage in telomerase-positive cancer cells. Cancer Research. PMID 31311806 DOI: 10.1158/0008-5472.Can-18-3594  0.37
2019 Klimkowski P, De Ornellas S, Singleton D, El-Sagheer AH, Brown T. Design of thiazole orange oligonucleotide probes for detection of DNA and RNA by fluorescence and duplex melting. Organic & Biomolecular Chemistry. PMID 31157811 DOI: 10.1039/C9Ob00885C  0.437
2019 Thorpe C, Epple S, Woods B, El-Sagheer AH, Brown T. Synthesis and biophysical properties of carbamate-locked nucleic acid (LNA) oligonucleotides with potential antisense applications. Organic & Biomolecular Chemistry. PMID 31099373 DOI: 10.1039/C9Ob00691E  0.445
2019 Taemaitree L, Shivalingam A, El-Sagheer AH, Brown T. An artificial triazole backbone linkage provides a split-and-click strategy to bioactive chemically modified CRISPR sgRNA. Nature Communications. 10: 1610. PMID 30962447 DOI: 10.1038/S41467-019-09600-4  0.381
2019 De Fazio AF, El-Sagheer AH, Kahn JS, Nandhakumar I, Burton MR, Brown T, Muskens OL, Gang O, Kanaras AG. Light-Induced Reversible DNA Ligation of Gold Nanoparticle Superlattices. Acs Nano. PMID 30958671 DOI: 10.1021/Acsnano.9B01294  0.35
2018 Chen J, Baker YR, Brown A, El-Sagheer AH, Brown T. Enzyme-free synthesis of cyclic single-stranded DNA constructs containing a single triazole, amide or phosphoramidate backbone linkage and their use as templates for rolling circle amplification and nanoflower formation. Chemical Science. 9: 8110-8120. PMID 30542561 DOI: 10.1039/C8Sc02952K  0.479
2018 Walsh S, El-Sagheer AH, Brown T. Fluorogenic thiazole orange TOTFO probes stabilise parallel DNA triplexes at pH 7 and above. Chemical Science. 9: 7681-7687. PMID 30393529 DOI: 10.1039/C8Sc02418A  0.391
2018 Lawson CP, Füchtbauer AF, Wranne MS, Giraud T, Floyd T, Dumat B, Andersen NK, H El-Sagheer A, Brown T, Gradén H, Wilhelmsson LM, Grøtli M. Synthesis, oligonucleotide incorporation and fluorescence properties in DNA of a bicyclic thymine analogue. Scientific Reports. 8: 13970. PMID 30228309 DOI: 10.1038/S41598-018-31897-2  0.494
2018 Fonvielle M, Bouhss A, Hoareau C, Patin D, Mengin-Lecreulx D, Iannazzo L, Sakkas N, El Sagheer A, Brown T, Ethève-Quelquejeu M, Arthur M. Synthesis of lipid-carbohydrate-peptidyl-RNA conjugates to explore the limits imposed by the substrate specificity of cell wall enzymes on the acquisition of drug resistance. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 30020544 DOI: 10.1002/Chem.201802360  0.308
2018 Baker YR, Chen J, Brown J, El-Sagheer AH, Wiseman P, Johnson E, Goddard P, Brown T. Preparation and characterization of manganese, cobalt and zinc DNA nanoflowers with tuneable morphology, DNA content and size. Nucleic Acids Research. PMID 30010979 DOI: 10.1093/Nar/Gky630  0.452
2018 Amunugama R, Willcox S, Wu RA, Abdullah UB, El-Sagheer AH, Brown T, McHugh PJ, Griffith JD, Walter JC. Replication Fork Reversal during DNA Interstrand Crosslink Repair Requires CMG Unloading. Cell Reports. 23: 3419-3428. PMID 29924986 DOI: 10.1016/J.Celrep.2018.05.061  0.396
2018 Bood M, Füchtbauer AF, Wranne MS, Ro JJ, Sarangamath S, El-Sagheer AH, Rupert DLM, Fisher RS, Magennis SW, Jones AC, Höök F, Brown T, Kim BH, Dahlén A, Wilhelmsson LM, et al. Pentacyclic adenine: a versatile and exceptionally bright fluorescent DNA base analogue. Chemical Science. 9: 3494-3502. PMID 29780479 DOI: 10.1039/C7Sc05448C  0.366
2018 Manuguerra I, Croce S, El-Sagheer AH, Krissanaprasit A, Brown T, Gothelf KV, Manetto A. Gene assembly via one-pot chemical ligation of DNA promoted by DNA nanostructures. Chemical Communications (Cambridge, England). PMID 29662975 DOI: 10.1039/C8Cc00738A  0.44
2018 Kyriazi ME, Giust D, El-Sagheer AH, Lackie PM, Muskens OL, Brown T, Kanaras AG. Multiplexed mRNA Sensing and Combinatorial-Targeted Drug Delivery Using DNA-Gold Nanoparticle Dimers. Acs Nano. PMID 29557641 DOI: 10.1021/Acsnano.7B08620  0.325
2018 Slator C, Molphy Z, McKee V, Long C, Brown T, Kellett A. Di-copper metallodrugs promote NCI-60 chemotherapy via singlet oxygen and superoxide production with tandem TA/TA and AT/AT oligonucleotide discrimination. Nucleic Acids Research. PMID 29474633 DOI: 10.1093/Nar/Gky105  0.381
2018 Midelet J, El-Sagheer AH, Brown T, Kanaras AG, Débarre A, Werts MHV. Spectroscopic and Hydrodynamic Characterisation of DNA-Linked Gold Nanoparticle Dimers in Solution using Two-Photon Photoluminescence. Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry. PMID 29465817 DOI: 10.1002/Cphc.201701228  0.36
2018 Vilela P, Heuer-Jungemann A, El-Sagheer A, Brown T, Muskens OL, Smyth NR, Kanaras AG. Sensing of Vimentin mRNA in 2D and 3D Models of Wounded Skin Using DNA-Coated Gold Nanoparticles. Small (Weinheim An Der Bergstrasse, Germany). PMID 29464860 DOI: 10.1002/Smll.201703489  0.308
2018 Hardwick JS, Lane AN, Brown T. Epigenetic Modifications of Cytosine: Biophysical Properties, Regulation, and Function in Mammalian DNA. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. PMID 29369386 DOI: 10.1002/Bies.201700199  0.429
2018 Andrews R, Steuer H, Shivalingam A, El-Sagheer AH, Brown T, Kapanidis AN. Short-Read Single-Molecule DNA Sequencing for Highly Parallel Analysis of Protein-DNA Interactions Biophysical Journal. 114: 92a. DOI: 10.1016/J.Bpj.2017.11.547  0.442
2017 Bosaeus N, Reymer A, Beke-Somfai T, Brown T, Takahashi M, Wittung-Stafshede P, Rocha S, Nordén B. A stretched conformation of DNA with a biological role? Quarterly Reviews of Biophysics. 50: e11. PMID 29233223 DOI: 10.1017/S0033583517000099  0.468
2017 Matysiak S, Hellmuth K, El-Sagheer AH, Shivalingam A, Ariyurek Y, de Jong M, Hollestelle MJ, Out R, Brown T. Searching for avidity by chemical ligation of combinatorially self-assembled DNA-encoded ligand libraries. Organic & Biomolecular Chemistry. PMID 29215120 DOI: 10.1039/C7Ob02119D  0.371
2017 Kukwikila M, Gale N, El-Sagheer AH, Brown T, Tavassoli A. Assembly of a biocompatible triazole-linked gene by one-pot click-DNA ligation. Nature Chemistry. 9: 1089-1098. PMID 29064492 DOI: 10.1038/Nchem.2850  0.369
2017 Howe FS, Russell A, Lamstaes AR, El-Sagheer A, Nair A, Brown T, Mellor J. CRISPRi is not strand-specific at all loci and redefines the transcriptional landscape. Elife. 6. PMID 29058669 DOI: 10.7554/Elife.29878  0.325
2017 El-Sagheer AH, Brown T. Single tube gene synthesis by phosphoramidate chemical ligation. Chemical Communications (Cambridge, England). PMID 28913522 DOI: 10.1039/C7Cc00858A  0.46
2017 Kumar P, El-Sagheer AH, Truong L, Brown T. Locked nucleic acid (LNA) enhances binding affinity of triazole-linked DNA towards RNA. Chemical Communications (Cambridge, England). PMID 28748236 DOI: 10.1039/C7Cc05159J  0.389
2017 Wranne MS, Füchtbauer AF, Dumat B, Bood MSR, El-Sagheer AH, Brown T, Gradén H, Grøtli M, Wilhelmsson LM. Towards complete sequence flexibility of nucleic acid base analogue FRET. Journal of the American Chemical Society. PMID 28613885 DOI: 10.1021/Jacs.7B04517  0.482
2017 Abdullah UB, McGouran JF, Brolih S, Ptchelkine D, El-Sagheer AH, Brown T, McHugh PJ. RPA activates the XPF-ERCC1 endonuclease to initiate processing of DNA interstrand crosslinks. The Embo Journal. PMID 28607004 DOI: 10.15252/Embj.201796664  0.44
2017 Hardwick JS, Ptchelkine D, El-Sagheer AH, Tear I, Singleton D, Phillips SEV, Lane AN, Brown T. 5-Formylcytosine does not change the global structure of DNA. Nature Structural & Molecular Biology. PMID 28504696 DOI: 10.1038/Nsmb.3411  0.411
2017 Shivalingam A, Tyburn AE, El-Sagheer AH, Brown T. Molecular Requirements of High-Fidelity Replication-Competent DNA Backbones for Orthogonal Chemical Ligation. Journal of the American Chemical Society. PMID 28097865 DOI: 10.1021/Jacs.6B11530  0.456
2017 Shaali M, Woller JG, Johansson PG, Hannestad JK, de Battice L, Aissaoui N, Brown T, El-Sagheer AH, Kubatkin S, Lara-Avila S, Albinsson B, Jesorka A. Site-selective immobilization of functionalized DNA origami on nanopatterned Teflon AF Journal of Materials Chemistry C. 5: 7637-7643. DOI: 10.1039/C7Tc01015J  0.389
2016 Plochowietz A, El-Sagheer AH, Brown T, Kapanidis AN. Stable end-sealed DNA as robust nano-rulers for single-molecule fluorescence. Chemical Science. 7: 4418-4422. PMID 30155088 DOI: 10.1039/C6Sc00639F  0.428
2016 Papadopoulou E, Gale N, Thompson JF, Fleming TA, Brown T, Bartlett PN. Specifically horizontally tethered DNA probes on Au surfaces allow labelled and label-free DNA detection using SERS and electrochemically driven melting. Chemical Science. 7: 386-393. PMID 29861989 DOI: 10.1039/C5Sc03185K  0.457
2016 Fonvielle M, Sakkas N, Iannazzo L, Le Fournis C, Patin D, Mengin-Lecreulx D, El-Sagheer A, Braud E, Cardon S, Brown T, Arthur M, Etheve-Quelquejeu M. Electrophilic RNA for Peptidyl-RNA Synthesis and Site-Specific Cross-Linking with tRNA-Binding Enzymes. Angewandte Chemie (International Ed. in English). PMID 27667506 DOI: 10.1002/Anie.201606843  0.302
2016 Haugland MM, El-Sagheer AH, Porter RJ, Pena J, Brown T, Anderson EA, Lovett JE. 2'-Alkynylnucleotides: A sequence- and spin label-flexible strategy for EPR spectroscopy in DNA. Journal of the American Chemical Society. PMID 27409454 DOI: 10.1021/Jacs.6B05421  0.792
2016 Qiu J, Wilson A, El-Sagheer AH, Brown T. Combination probes with intercalating anchors and proximal fluorophores for DNA and RNA detection. Nucleic Acids Research. PMID 27369379 DOI: 10.1093/Nar/Gkw579  0.416
2016 Shivalingam A, Brown T. Synthesis of chemically modified DNA. Biochemical Society Transactions. 44: 709-15. PMID 27284032 DOI: 10.1042/Bst20160051  0.464
2016 Meng W, Muscat RA, McKee ML, Milnes PJ, El-Sagheer AH, Bath J, Davis BG, Brown T, O'Reilly RK, Turberfield AJ. An autonomous molecular assembler for programmable chemical synthesis. Nature Chemistry. 8: 542-548. PMID 27219697 DOI: 10.1038/Nchem.2495  0.406
2016 Ren X, El-Sagheer AH, Brown T. Efficient enzymatic synthesis and dual-colour fluorescent labelling of DNA probes using long chain azido-dUTP and BCN dyes. Nucleic Acids Research. PMID 26819406 DOI: 10.1093/Nar/Gkw028  0.443
2015 El-Sagheer AH, Brown T. A triazole linkage that mimics the DNA phosphodiester group in living systems. Quarterly Reviews of Biophysics. 48: 429-36. PMID 26537402 DOI: 10.1017/S0033583515000141  0.47
2015 Kimber ST, Brown T, Fox KR. The effect of sequence context on the activity of cytosine DNA glycosylases. Molecular Biosystems. PMID 26463365 DOI: 10.1039/C5Mb00532A  0.417
2015 Harimech PK, Gerrard SR, El-Sagheer AH, Brown T, Kanaras AG. Reversible Ligation of Programmed DNA-Gold Nanoparticle Assemblies. Journal of the American Chemical Society. 137: 9242-5. PMID 26192342 DOI: 10.1021/Jacs.5B05683  0.387
2015 Papadopoulou E, Meneghello M, Marafini P, Johnson RP, Brown T, Bartlett PN. The effect of temperature on electrochemically driven denaturation monitored by SERS. Bioelectrochemistry (Amsterdam, Netherlands). PMID 26145815 DOI: 10.1016/J.Bioelechem.2015.06.007  0.307
2015 French DJ, Richardson JA, Howard RL, Brown T, Debenham PG. Synthesis and use of universal sequence probes in fluorogenic multi-strand hybridisation complexes for economical nucleic acid testing. Molecular and Cellular Probes. PMID 25981184 DOI: 10.1016/J.Mcp.2015.05.007  0.35
2015 Ren X, El-Sagheer AH, Brown T. Azide and trans-cyclooctene dUTPs: incorporation into DNA probes and fluorescent click-labelling. The Analyst. 140: 2671-8. PMID 25734317 DOI: 10.1039/C5An00158G  0.467
2015 Bälter M, Hammarson M, Remón P, Li S, Gale N, Brown T, Andréasson J. Reversible energy-transfer switching on a DNA scaffold. Journal of the American Chemical Society. 137: 2444-7. PMID 25687828 DOI: 10.1021/Ja512416N  0.346
2015 Alonso-Cristobal P, Vilela P, El-Sagheer A, Lopez-Cabarcos E, Brown T, Muskens OL, Rubio-Retama J, Kanaras AG. Highly Sensitive DNA Sensor Based on Upconversion Nanoparticles and Graphene Oxide. Acs Applied Materials & Interfaces. 7: 12422-9. PMID 25622622 DOI: 10.1021/Am507591U  0.412
2015 Papadopoulou E, Goodchild SA, Cleary DW, Weller SA, Gale N, Stubberfield MR, Brown T, Bartlett PN. Using surface-enhanced Raman spectroscopy and electrochemically driven melting to discriminate Yersinia pestis from Y. pseudotuberculosis based on single nucleotide polymorphisms within unpurified polymerase chain reaction amplicons. Analytical Chemistry. 87: 1605-12. PMID 25551670 DOI: 10.1021/Ac503063C  0.408
2015 Howard RL, French DJ, Richardson JA, O'Neill CE, Andreou MP, Brown T, Clark D, Clarke IN, Holloway JW, Marsh P, Debenham PG. Rapid detection of diagnostic targets using isothermal amplification and HyBeacon probes--a homogenous system for sequence-specific detection. Molecular and Cellular Probes. 29: 92-8. PMID 25542839 DOI: 10.1016/J.Mcp.2014.12.001  0.319
2015 Heuer-Jungemann A, Kiessling L, Stratakis E, Kymakis E, El-Sagheer AH, Brown T, Kanaras AG. Programming the assembly of gold nanoparticles on graphene oxide sheets using DNA Journal of Materials Chemistry C. 3: 9379-9384. DOI: 10.1039/C5Tc01999K  0.333
2015 Papadopoulou E, Gale N, Goodchild SA, Cleary DW, Weller SA, Brown T, Bartlett PN. Strain discrimination of Yersinia pestis using a SERS-based electrochemically driven melting curve analysis of variable number tandem repeat sequences Chemical Science. 6: 1846-1852. DOI: 10.1039/C4Sc03084B  0.321
2015 Plochowietz A, Llumigusin DD, Zawadzki P, El-Sagheer AH, Brown T, Kapanidis AN. Real-Time Transcription Initiation by E. coli RNA Polymerase in vitro and in vivo Biophysical Journal. 108: 115a. DOI: 10.1016/J.Bpj.2014.11.646  0.378
2014 Ren X, Gerowska M, El-Sagheer AH, Brown T. Enzymatic incorporation and fluorescent labelling of cyclooctyne-modified deoxyuridine triphosphates in DNA. Bioorganic & Medicinal Chemistry. 22: 4384-90. PMID 24953951 DOI: 10.1016/J.Bmc.2014.05.050  0.465
2014 Chen X, El-Sagheer AH, Brown T. Reverse transcription through a bulky triazole linkage in RNA: implications for RNA sequencing. Chemical Communications (Cambridge, England). 50: 7597-600. PMID 24889467 DOI: 10.1039/C4Cc03027C  0.305
2014 Bosaeus N, El-Sagheer AH, Brown T, Ã…kerman B, Nordén B. Force-induced melting of DNA--evidence for peeling and internal melting from force spectra on short synthetic duplex sequences. Nucleic Acids Research. 42: 8083-91. PMID 24838568 DOI: 10.1093/Nar/Gku441  0.422
2014 Kimber ST, Brown T, Fox KR. A mutant of uracil DNA glycosylase that distinguishes between cytosine and 5-methylcytosine. Plos One. 9: e95394. PMID 24740413 DOI: 10.1371/Journal.Pone.0095394  0.427
2014 Rusling DA, Chandrasekaran AR, Ohayon YP, Brown T, Fox KR, Sha R, Mao C, Seeman NC. Functionalizing designer DNA crystals with a triple-helical veneer. Angewandte Chemie (International Ed. in English). 53: 3979-82. PMID 24615910 DOI: 10.1002/Anie.201309914  0.4
2014 Birts CN, Sanzone AP, El-Sagheer AH, Blaydes JP, Brown T, Tavassoli A. Transcription of click-linked DNA in human cells. Angewandte Chemie (International Ed. in English). 53: 2362-5. PMID 24452865 DOI: 10.1002/Anie.201308691  0.455
2014 Riley JA, Brown T, Gale N, Herniman J, Langley GJ. Self-reporting hybridisation assay for miRNA analysis. The Analyst. 139: 1088-92. PMID 24404560 DOI: 10.1039/C3An01825C  0.318
2014 Lercher L, McDonough MA, El-Sagheer AH, Thalhammer A, Kriaucionis S, Brown T, Schofield CJ. Structural insights into how 5-hydroxymethylation influences transcription factor binding. Chemical Communications (Cambridge, England). 50: 1794-6. PMID 24287551 DOI: 10.1039/C3Cc48151D  0.316
2014 Johannsen MW, Gerrard SR, Melvin T, Brown T. Triplex-mediated analysis of cytosine methylation at CpA sites in DNA. Chemical Communications (Cambridge, England). 50: 551-3. PMID 24276836 DOI: 10.1039/C3Cc45917A  0.383
2014 Lou C, Dallmann A, Marafini P, Gao R, Brown T. Enhanced H-bonding and π-stacking in DNA: A potent duplex-stabilizing and mismatch sensing nucleobase analogue Chemical Science. 5: 3836-3844. DOI: 10.1039/C4Sc00948G  0.439
2014 El-Sagheer AH, Brown T. Combined nucleobase and backbone modifications enhance DNA duplex stability and preserve biocompatibility Chem. Sci.. 5: 253-259. DOI: 10.1039/C3Sc51753E  0.475
2014 Birts CN, Sanzone AP, El-Sagheer AH, Blaydes JP, Brown T, Tavassoli A. Inside Back Cover: Transcription of Click-Linked DNA in Human Cells (Angew. Chem. Int. Ed. 9/2014) Angewandte Chemie International Edition. 53: 2509-2509. DOI: 10.1002/Anie.201400939  0.382
2014 Birts CN, Sanzone AP, El-Sagheer AH, Blaydes JP, Brown T, Tavassoli A. Innenrücktitelbild: Transcription of Click-Linked DNA in Human Cells (Angew. Chem. 9/2014) Angewandte Chemie. 126: 2543-2543. DOI: 10.1002/Ange.201400939  0.389
2013 Heuer-Jungemann A, Harimech PK, Brown T, Kanaras AG. Gold nanoparticles and fluorescently-labelled DNA as a platform for biological sensing. Nanoscale. 5: 9503-10. PMID 23982570 DOI: 10.1039/C3Nr03707J  0.326
2013 Heuer-Jungemann A, Kirkwood R, El-Sagheer AH, Brown T, Kanaras AG. Copper-free click chemistry as an emerging tool for the programmed ligation of DNA-functionalised gold nanoparticles. Nanoscale. 5: 7209-12. PMID 23828172 DOI: 10.1039/C3Nr02362A  0.305
2013 Qiu J, El-Sagheer AH, Brown T. Solid phase click ligation for the synthesis of very long oligonucleotides. Chemical Communications (Cambridge, England). 49: 6959-61. PMID 23814786 DOI: 10.1039/C3Cc42451K  0.358
2013 Richardson JA, Morgan T, Andreou M, Brown T. Use of a large Stokes-shift fluorophore to increase the multiplexing capacity of a point-of-care DNA diagnostic device. The Analyst. 138: 3626-8. PMID 23675581 DOI: 10.1039/C3An00593C  0.35
2013 Wu L, Reymer A, Persson C, Kazimierczuk K, Brown T, Lincoln P, Nordén B, Billeter M. Initial DNA interactions of the binuclear threading intercalator Λ,Λ-[μ-bidppz(bipy)4Ru2]4+: an NMR study with [d(CGCGAATTCGCG)]2. Chemistry (Weinheim An Der Bergstrasse, Germany). 19: 5401-10. PMID 23447081 DOI: 10.1002/Chem.201203175  0.452
2013 Milton JA, Patole S, Yin H, Xiao Q, Brown T, Melvin T. Efficient self-assembly of DNA-functionalized fluorophores and gold nanoparticles with DNA functionalized silicon surfaces: the effect of oligomer spacers. Nucleic Acids Research. 41: e80. PMID 23361467 DOI: 10.1093/Nar/Gkt031  0.431
2013 Crawford R, Erben CM, Periz J, Hall LM, Brown T, Turberfield AJ, Kapanidis AN. Non-covalent single transcription factor encapsulation inside a DNA cage. Angewandte Chemie (International Ed. in English). 52: 2284-8. PMID 23325751 DOI: 10.1002/Anie.201207914  0.426
2013 Hannestad JK, Brune R, Czolkos I, Jesorka A, El-Sagheer AH, Brown T, Albinsson B, Orwar O. Kinetics of diffusion-mediated DNA hybridization in lipid monolayer films determined by single-molecule fluorescence spectroscopy. Acs Nano. 7: 308-15. PMID 23215045 DOI: 10.1021/Nn304010P  0.445
2013 Johnson RP, Gale N, Richardson JA, Brown T, Bartlett PN. Denaturation of dsDNA immobilised at a negatively charged gold electrode is not caused by electrostatic repulsion Chemical Science. 4: 1625-1632. DOI: 10.1039/C3Sc22147D  0.366
2012 Gerrard SR, Hardiman C, Shelbourne M, Nandhakumar I, Nordén B, Brown T. A new modular approach to nanoassembly: stable and addressable DNA nanoconstructs via orthogonal click chemistries. Acs Nano. 6: 9221-8. PMID 22989197 DOI: 10.1021/Nn3035759  0.467
2012 Bosaeus N, El-Sagheer AH, Brown T, Smith SB, Akerman B, Bustamante C, Nordén B. Tension induces a base-paired overstretched DNA conformation. Proceedings of the National Academy of Sciences of the United States of America. 109: 15179-84. PMID 22949705 DOI: 10.1073/Pnas.1213172109  0.456
2012 Rusling DA, Nandhakumar IS, Brown T, Fox KR. Triplex-directed covalent cross-linking of a DNA nanostructure. Chemical Communications (Cambridge, England). 48: 9592-4. PMID 22911369 DOI: 10.1039/C2Cc35407A  0.457
2012 Sanzone AP, El-Sagheer AH, Brown T, Tavassoli A. Assessing the biocompatibility of click-linked DNA in Escherichia coli. Nucleic Acids Research. 40: 10567-75. PMID 22904087 DOI: 10.1093/Nar/Gks756  0.453
2012 Shelbourne M, Brown T, El-Sagheer AH, Brown T. Fast and efficient DNA crosslinking and multiple orthogonal labelling by copper-free click chemistry. Chemical Communications (Cambridge, England). 48: 11184-6. PMID 22892959 DOI: 10.1039/C2Cc35084J  0.454
2012 Johnson RP, Richardson JA, Brown T, Bartlett PN. A label-free, electrochemical SERS-based assay for detection of DNA hybridization and discrimination of mutations. Journal of the American Chemical Society. 134: 14099-107. PMID 22835041 DOI: 10.1021/Ja304663T  0.417
2012 Hall LM, Gerowska M, Brown T. A highly fluorescent DNA toolkit: synthesis and properties of oligonucleotides containing new Cy3, Cy5 and Cy3B monomers. Nucleic Acids Research. 40: e108. PMID 22495935 DOI: 10.1093/Nar/Gks303  0.411
2012 Rusling DA, Nandhakumar IS, Brown T, Fox KR. Triplex-directed recognition of a DNA nanostructure assembled by crossover strand exchange. Acs Nano. 6: 3604-13. PMID 22443318 DOI: 10.1021/Nn300718Z  0.465
2012 El-Sagheer AH, Brown T. Click nucleic acid ligation: applications in biology and nanotechnology. Accounts of Chemical Research. 45: 1258-67. PMID 22439702 DOI: 10.1021/Ar200321N  0.507
2012 Dierckx A, Miannay FA, Ben Gaied N, Preus S, Björck M, Brown T, Wilhelmsson LM. Quadracyclic adenine: a non-perturbing fluorescent adenine analogue. Chemistry (Weinheim An Der Bergstrasse, Germany). 18: 5987-97. PMID 22437923 DOI: 10.1002/Chem.201103419  0.408
2012 Johnson RP, Richardson JA, Brown T, Bartlett PN. Real-time surface-enhanced Raman spectroscopy monitoring of surface pH during electrochemical melting of double-stranded DNA. Langmuir : the Acs Journal of Surfaces and Colloids. 28: 5464-70. PMID 22369584 DOI: 10.1021/La204794G  0.346
2012 Johnson RP, Gao R, Brown T, Bartlett PN. The effect of base-pair sequence on electrochemically driven denaturation. Bioelectrochemistry (Amsterdam, Netherlands). 85: 7-13. PMID 22192638 DOI: 10.1016/J.Bioelechem.2011.11.003  0.367
2012 Cardew AS, Brown T, Fox KR. Secondary binding sites for heavily modified triplex forming oligonucleotides. Nucleic Acids Research. 40: 3753-62. PMID 22180535 DOI: 10.1093/Nar/Gkr1119  0.396
2012 Gerowska M, Hall L, Richardson J, Shelbourne M, Brown T. Efficient reverse click labeling of azide oligonucleotides with multiple alkynyl Cy-Dyes applied to the synthesis of HyBeacon probes for genetic analysis Tetrahedron. 68: 857-864. DOI: 10.1016/J.Tet.2011.11.041  0.406
2011 Dallmann A, El-Sagheer AH, Dehmel L, Mügge C, Griesinger C, Ernsting NP, Brown T. Structure and dynamics of triazole-linked DNA: Biocompatibility explained Chemistry - a European Journal. 17: 14714-14717. PMID 22131102 DOI: 10.1002/Chem.201102979  0.41
2011 Lou C, Shelbourne M, Fox KR, Brown T. 2'-Aminoethoxy-2-amino-3-methylpyridine in triplex-forming oligonucleotides: high affinity, selectivity and resistance to enzymatic degradation. Chemistry (Weinheim An Der Bergstrasse, Germany). 17: 14851-6. PMID 22127905 DOI: 10.1002/Chem.201102287  0.33
2011 el-Sagheer AH, Brown T. Efficient RNA synthesis by in vitro transcription of a triazole-modified DNA template. Chemical Communications (Cambridge, England). 47: 12057-8. PMID 21961113 DOI: 10.1039/C1Cc14316F  0.457
2011 Hannestad JK, Gerrard SR, Brown T, Albinsson B. Self-assembled DNA-based fluorescence waveguide with selectable output. Small (Weinheim An Der Bergstrasse, Germany). 7: 3178-85. PMID 21901828 DOI: 10.1002/Smll.201101144  0.341
2011 Lundberg EP, Plesa C, Wilhelmsson LM, Lincoln P, Brown T, Nordén B. Nanofabrication yields. Hybridization and click-fixation of polycyclic DNA nanoassemblies. Acs Nano. 5: 7565-75. PMID 21827213 DOI: 10.1021/Nn202568Q  0.416
2011 El-Sagheer AH, Sanzone AP, Gao R, Tavassoli A, Brown T. Biocompatible artificial DNA linker that is read through by DNA polymerases and is functional in Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 108: 11338-43. PMID 21709264 DOI: 10.1073/Pnas.1101519108  0.477
2011 Shelbourne M, Chen X, Brown T, El-Sagheer AH. Fast copper-free click DNA ligation by the ring-strain promoted alkyne-azide cycloaddition reaction. Chemical Communications (Cambridge, England). 47: 6257-9. PMID 21547301 DOI: 10.1039/C1Cc10743G  0.376
2011 Walsh JM, Bouamaied I, Brown T, Wilhelmsson LM, Beuning PJ. Discrimination against the cytosine analog tC by Escherichia coli DNA polymerase IV DinB. Journal of Molecular Biology. 409: 89-100. PMID 21477595 DOI: 10.1016/J.Jmb.2011.03.069  0.485
2011 Thalhammer A, Hansen AS, El-Sagheer AH, Brown T, Schofield CJ. Hydroxylation of methylated CpG dinucleotides reverses stabilisation of DNA duplexes by cytosine 5-methylation. Chemical Communications (Cambridge, England). 47: 5325-7. PMID 21451870 DOI: 10.1039/C0Cc05671E  0.37
2011 Fox KR, Brown T. Formation of stable DNA triplexes. Biochemical Society Transactions. 39: 629-34. PMID 21428952 DOI: 10.1042/Bst0390629  0.452
2011 Ranasinghe RT, Brown T. Ultrasensitive fluorescence-based methods for nucleic acid detection: towards amplification-free genetic analysis. Chemical Communications (Cambridge, England). 47: 3717-35. PMID 21283891 DOI: 10.1039/C0Cc04215C  0.345
2011 Dierckx A, Dinér P, El-Sagheer AH, Kumar JD, Brown T, Grøtli M, Wilhelmsson LM. Characterization of photophysical and base-mimicking properties of a novel fluorescent adenine analogue in DNA. Nucleic Acids Research. 39: 4513-24. PMID 21278417 DOI: 10.1093/Nar/Gkr010  0.447
2011 Hansen AS, Thalhammer A, El-Sagheer AH, Brown T, Schofield CJ. Improved synthesis of 5-hydroxymethyl-2'-deoxycytidine phosphoramidite using a 2'-deoxyuridine to 2'-deoxycytidine conversion without temporary protecting groups. Bioorganic & Medicinal Chemistry Letters. 21: 1181-4. PMID 21256007 DOI: 10.1016/J.Bmcl.2010.12.098  0.396
2011 Rindermann JJ, Akhtman Y, Richardson J, Brown T, Lagoudakis PG. Gauging the flexibility of fluorescent markers for the interpretation of fluorescence resonance energy transfer. Journal of the American Chemical Society. 133: 279-85. PMID 21155557 DOI: 10.1021/Ja105720J  0.323
2011 El-Sagheer AH, Cheong VV, Brown T. Rapid chemical ligation of oligonucleotides by the Diels-Alder reaction. Organic & Biomolecular Chemistry. 9: 232-5. PMID 21072410 DOI: 10.1039/C0Ob00451K  0.349
2011 El-Sagheer AH, Brown T. Click DNA and RNA ligation for new biocompatible nucleic acid backbone mimics Collection of Czechoslovak Chemical Communications. 12: 10-17. DOI: 10.1135/Css201112010  0.42
2010 Gerrard SR, Edrees MM, Bouamaied I, Fox KR, Brown T. CG base pair recognition within DNA triple helices by modified N-methylpyrrolo-dC nucleosides. Organic & Biomolecular Chemistry. 8: 5087-96. PMID 20835452 DOI: 10.1039/C0Ob00119H  0.38
2010 Börjesson K, Wiberg J, El-Sagheer AH, Ljungdahl T, Mårtensson J, Brown T, Nordén B, Albinsson B. Functionalized nanostructures: redox-active porphyrin anchors for supramolecular DNA assemblies. Acs Nano. 4: 5037-46. PMID 20809571 DOI: 10.1021/Nn100667B  0.391
2010 El-Sagheer AH, Brown T. New strategy for the synthesis of chemically modified RNA constructs exemplified by hairpin and hammerhead ribozymes. Proceedings of the National Academy of Sciences of the United States of America. 107: 15329-34. PMID 20713730 DOI: 10.1073/Pnas.1006447107  0.349
2010 Lou C, Xiao Q, Brennan L, Light ME, Vergara-Irigaray N, Atkinson EM, Holden-Dye LM, Fox KR, Brown T. Synthesis and properties of triplex-forming oligonucleotides containing 2'-O-(2-methoxyethyl)-5-(3-aminoprop-1-ynyl)-uridine. Bioorganic & Medicinal Chemistry. 18: 6389-97. PMID 20674370 DOI: 10.1016/J.Bmc.2010.07.005  0.33
2010 Gambinossi F, Banchelli M, Durand A, Berti D, Brown T, Caminati G, Baglioni P. Modulation of density and orientation of amphiphilic DNA anchored to phospholipid membranes. I. Supported lipid bilayers. The Journal of Physical Chemistry. B. 114: 7338-47. PMID 20446700 DOI: 10.1021/Jp100730X  0.342
2010 Banchelli M, Gambinossi F, Durand A, Caminati G, Brown T, Berti D, Baglioni P. Modulation of density and orientation of amphiphilic DNA on phospholipid membranes. II. Vesicles. The Journal of Physical Chemistry. B. 114: 7348-58. PMID 20446699 DOI: 10.1021/Jp100731C  0.372
2010 Ben Gaied N, Richardson JA, Singleton DG, Zhao Z, French D, Brown T. End-capped HyBeacon probes for the analysis of human genetic polymorphisms related to warfarin metabolism. Organic & Biomolecular Chemistry. 8: 2728-34. PMID 20393654 DOI: 10.1039/C001177K  0.342
2010 Lundberg EP, El-Sagheer AH, Kocalka P, Wilhelmsson LM, Brown T, Nordén B. A new fixation strategy for addressable nano-network building blocks. Chemical Communications (Cambridge, England). 46: 3714-6. PMID 20386862 DOI: 10.1039/C001513J  0.397
2010 El-Sagheer AH, Brown T. Click chemistry with DNA. Chemical Society Reviews. 39: 1388-405. PMID 20309492 DOI: 10.1039/B901971P  0.473
2010 Lundberg EP, El-Sagheer AH, Kocalka P, Wilhelmsson ML, Brown T, Nordén B. Fixation of Self-Assembled DNA Nanostructures by Simultaneous Multicenter Click Chemistry Biophysical Journal. 98: 6-8. DOI: 10.1016/J.Bpj.2009.12.3609  0.414
2010 Hohlbein J, Le Reste L, Potapova O, Joyce C, El-Sagheer AH, Brown T, Kapanidis AN. Towards Dark Quencher Based Real Time DNA Sequencing Biophysical Journal. 98: 611a-612a. DOI: 10.1016/J.Bpj.2009.12.3336  0.476
2010 Preus S, Börjesson K, Kilså K, El-Sagheer AH, Brown T, Albinsson B, Wilhelmsson LM. The First All-Nucleobase Analog FRET Pair Biophysical Journal. 98: 582a. DOI: 10.1016/J.Bpj.2009.12.3164  0.454
2009 Chernatynskaya AV, Deleeuw L, Trent JO, Brown T, Lane AN. Structural analysis of the DNA target site and its interaction with Mbp1. Organic & Biomolecular Chemistry. 7: 4981-91. PMID 19907790 DOI: 10.1039/B912309A  0.479
2009 Rusling DA, Rachwal PA, Brown T, Fox KR. The stability of triplex DNA is affected by the stability of the underlying duplex. Biophysical Chemistry. 145: 105-10. PMID 19819611 DOI: 10.1016/J.Bpc.2009.09.007  0.446
2009 Ben Gaied N, Zhao Z, Gerrard SR, Fox KR, Brown T. Potent triple helix stabilization by 5',3'-modified triplex-forming oligonucleotides. Chembiochem : a European Journal of Chemical Biology. 10: 1839-51. PMID 19554592 DOI: 10.1002/Cbic.200900232  0.349
2009 Yang QH, Wang Q, Gale N, Oton CJ, Cui L, Nandhakumar IS, Zhu Z, Tang Z, Brown T, Loh WH. Loosening the DNA wrapping around single-walled carbon nanotubes by increasing the strand length. Nanotechnology. 20: 195603. PMID 19420642 DOI: 10.1088/0957-4484/20/19/195603  0.405
2009 Börjesson K, Preus S, El-Sagheer AH, Brown T, Albinsson B, Wilhelmsson LM. Nucleic acid base analog FRET-pair facilitating detailed structural measurements in nucleic acid containing systems. Journal of the American Chemical Society. 131: 4288-93. PMID 19317504 DOI: 10.1021/Ja806944W  0.395
2009 El-Sagheer AH, Brown T. Synthesis and polymerase chain reaction amplification of DNA strands containing an unnatural triazole linkage. Journal of the American Chemical Society. 131: 3958-64. PMID 19292490 DOI: 10.1021/Ja8065896  0.475
2009 Börjesson K, Tumpane J, Ljungdahl T, Wilhelmsson LM, Nordén B, Brown T, Mårtensson J, Albinsson B. Membrane-anchored DNA assembly for energy and electron transfer. Journal of the American Chemical Society. 131: 2831-9. PMID 19199439 DOI: 10.1021/Ja8038294  0.339
2009 Rusling DA, Peng G, Srinivasan N, Fox KR, Brown T. DNA triplex formation with 5-dimethylaminopropargyl deoxyuridine. Nucleic Acids Research. 37: 1288-96. PMID 19139069 DOI: 10.1093/Nar/Gkn1060  0.411
2009 El-Sagheer AH, Brown T. Synthesis of alkyne- and azide-modified oligonucleotides and their cyclization by the CuAAC (click) reaction. Current Protocols in Nucleic Acid Chemistry. Unit 4.33. PMID 19085984 DOI: 10.1002/0471142700.Nc0433S35  0.387
2009 Baldelli Bombelli F, Betti F, Gambinossi F, Caminati G, Brown T, Baglioni P, Berti D. Closed nanoconstructs assembled by step-by-step ss-DNA coupling assisted by phospholipid membranes Soft Matter. 5: 1639-1645. DOI: 10.1039/B816716H  0.399
2009 Sandin P, Tumpane J, Börjesson K, Wilhelmsson LM, Brown T, Nordén B, Albinsson B, Lincoln P. Thermodynamic Aspects of DNA Nanoconstruct Stability and Design The Journal of Physical Chemistry C. 113: 5941-5946. DOI: 10.1021/Jp808239A  0.446
2009 Mahajan S, Richardson J, Gaied NB, Zhao Z, Brown T, Bartlett PN. The use of an electroactive marker as a SERS label in an E-melting mutation discrimination assay Electroanalysis. 21: 2190-2197. DOI: 10.1002/Elan.200904681  0.338
2008 French DJ, Howard RL, Gale N, Brown T, McDowell DG, Debenham PG. Interrogation of short tandem repeats using fluorescent probes and melting curve analysis: a step towards rapid DNA identity screening. Forensic Science International. Genetics. 2: 333-9. PMID 19083844 DOI: 10.1016/J.Fsigen.2008.04.007  0.374
2008 Gale N, French DJ, Howard RL, McDowell DG, Debenham PG, Brown T. Rapid typing of STRs in the human genome by HyBeacon melting. Organic & Biomolecular Chemistry. 6: 4553-9. PMID 19039363 DOI: 10.1039/B813431F  0.378
2008 Mahajan S, Richardson J, Brown T, Bartlett PN. SERS-melting: A new method for discriminating mutations in DNA sequences Journal of the American Chemical Society. 130: 15589-15601. PMID 19006412 DOI: 10.1021/Ja805517Q  0.404
2008 Bombelli FB, Gambinossi F, Lagi M, Berti D, Caminati G, Brown T, Sciortino F, Norden B, Baglioni P. DNA closed nanostructures: a structural and Monte Carlo simulation study. The Journal of Physical Chemistry. B. 112: 15283-94. PMID 18989907 DOI: 10.1021/Jp804544U  0.422
2008 Nordell P, Westerlund F, Reymer A, El-Sagheer AH, Brown T, Nordén B, Lincoln P. DNA polymorphism as an origin of adenine-thymine tract length-dependent threading intercalation rate. Journal of the American Chemical Society. 130: 14651-8. PMID 18847262 DOI: 10.1021/Ja804427Q  0.467
2008 Börjesson K, Tumpane J, Ljungdahl T, Wilhelmsson LM, Nordén B, Brown T, Mårtensson J, Albinsson B. A membrane anchored DNA-based energy/electron transfer assembly. Nucleic Acids Symposium Series (2004). 691. PMID 18776568 DOI: 10.1135/Css200810325  0.326
2008 Lundberg E, Tumpane J, Kumar R, Sandin P, Gale N, Nandhakumar IS, Albinsson B, Lincoln P, Wilhelmsson LM, Brown T, Nordén B. Addressable molecular node assembly--high information density DNA nanostructures. Nucleic Acids Symposium Series (2004). 683-4. PMID 18776564 DOI: 10.1093/nass/nrn345  0.338
2008 Börjesson K, Sandin P, Albinsson B, Mårtensson J, Brown T, Wilhelmsson LM. Characterization and use of tricyclic fluorescent nucleic acid base analogues. Nucleic Acids Symposium Series (2004). 3-4. PMID 18776224 DOI: 10.1093/nass/nrn002  0.315
2008 French DJ, McDowell DG, Debenham P, Gale N, Brown T. HyBeacon probes for rapid DNA sequence detection and allele discrimination Methods in Molecular Biology (Clifton, N.J.). 429: 171-185. PMID 18695966 DOI: 10.1007/978-1-60327-040-3_12  0.39
2008 Banchelli M, Betti F, Berti D, Caminati G, Bombelli FB, Brown T, Wilhelmsson LM, Nordén B, Baglioni P. Phospholipid membranes decorated by cholesterol-based oligonucleotides as soft hybrid nanostructures. The Journal of Physical Chemistry. B. 112: 10942-52. PMID 18693696 DOI: 10.1021/Jp802415T  0.417
2008 Kocalka P, El-Sagheer AH, Brown T. Rapid and efficient DNA strand cross-linking by click chemistry. Chembiochem : a European Journal of Chemical Biology. 9: 1280-5. PMID 18418819 DOI: 10.1002/Cbic.200800006  0.398
2008 Rusling DA, Broughton-Head VJ, Tuck A, Khairallah H, Osborne SD, Brown T, Fox KR. Kinetic studies on the formation of DNA triplexes containing the nucleoside analogue 2′-O-(2-aminoethyl)-5-(3-amino-1-propynyl)uridine Organic and Biomolecular Chemistry. 6: 122-129. PMID 18075656 DOI: 10.1039/B713088K  0.365
2008 El-Sagheer AH, Kumar R, Findlow S, Werner JM, Lane AN, Brown T. A very stable cyclic DNA miniduplex with just two base pairs. Chembiochem : a European Journal of Chemical Biology. 9: 50-2. PMID 18058775 DOI: 10.1002/Cbic.200700538  0.441
2008 Sandin P, Börjesson K, Li H, Mårtensson J, Brown T, Wilhelmsson LM, Albinsson B. Characterization and use of an unprecedentedly bright and structurally non-perturbing fluorescent DNA base analogue. Nucleic Acids Research. 36: 157-67. PMID 18003656 DOI: 10.1093/Nar/Gkm1006  0.448
2008 Rusling DA, Broughton-Head VJ, Brown T, Fox KR. Towards the targeted modulation of gene expression by modified triplex-forming oligonucleotides Current Chemical Biology. 2: 1-10. DOI: 10.2174/187231308783334135  0.462
2008 El-Sagheer AH, Brown T. Synthesis, Serum Stability and Cell Uptake of Cyclic and Hairpin Decoy Oligonucleotides for TCF/LEF and GLI Transcription Factors International Journal of Peptide Research and Therapeutics. 14: 367-372. DOI: 10.1007/S10989-008-9153-0  0.337
2007 Erkan Y, Halma K, Czolkos I, Jesorka A, Dommersnes P, Kumar R, Brown T, Orwar O. Controlled release of chol-TEG-DNA from Nano- and micropatterned SU-8 surfaces by a spreading lipid film. Nano Letters. 8: 227-31. PMID 18069872 DOI: 10.1021/Nl0725087  0.399
2007 Durand A, Brown T. Synthesis and properties of oligonucleotides containing a cholesterol thymidine monomer Nucleosides, Nucleotides and Nucleic Acids. 26: 785-794. PMID 18066901 DOI: 10.1080/15257770701501534  0.379
2007 Gerrard SR, Srinivasan N, Fox KR, Brown T. CG base pair recognition within DNA triple helices using N-methyl-3H-pyrrolo[2,3-d]pyrimidin-2(7H)-one nucleoside analogues. Nucleosides, Nucleotides & Nucleic Acids. 26: 1363-7. PMID 18066784 DOI: 10.1080/15257770701533958  0.381
2007 Li H, Broughton-Head VJ, Fox KR, Brown T. Photoinduced crosslinking of double-helical DNA by psoralen covalently linked to a triple helix-forming oligonucleotide under near-physiological conditions Nucleosides, Nucleotides and Nucleic Acids. 26: 1005-1009. PMID 18058526 DOI: 10.1080/15257770701508554  0.417
2007 Zhao Z, Peng G, Michels J, Fox KR, Brown T. Synthesis of anthraquinone oligonucleotides for triplex stabilization Nucleosides, Nucleotides and Nucleic Acids. 26: 921-925. PMID 18058509 DOI: 10.1080/15257770701506491  0.308
2007 Tumpane J, Kumar R, Lundberg EP, Sandin P, Gale N, Nandhakumar IS, Albinsson B, Lincoln P, Wilhelmsson LM, Brown T, Nordén B. Triplex addressability as a basis for functional DNA nanostructures. Nano Letters. 7: 3832-9. PMID 17983251 DOI: 10.1021/Nl072512I  0.438
2007 Rachwal PA, Findlow IS, Werner JM, Brown T, Fox KR. Intramolecular DNA quadruplexes with different arrangements of short and long loops. Nucleic Acids Research. 35: 4214-22. PMID 17576685 DOI: 10.1093/Nar/Gkm316  0.35
2007 Kumar R, El-Sagheer A, Tumpane J, Lincoln P, Wilhelmsson LM, Brown T. Template-directed oligonucleotide strand ligation, covalent intramolecular DNA circularization and catenation using click chemistry. Journal of the American Chemical Society. 129: 6859-64. PMID 17488075 DOI: 10.1021/Ja070273V  0.47
2007 Sandin P, Lincoln P, Brown T, Wilhelmsson LM. Synthesis and oligonucleotide incorporation of fluorescent cytosine analogue tC: a promising nucleic acid probe. Nature Protocols. 2: 615-23. PMID 17406622 DOI: 10.1038/Nprot.2007.80  0.375
2007 Rachwal PA, Brown T, Fox KR. Sequence effects of single base loops in intramolecular quadruplex DNA. Febs Letters. 581: 1657-1660. PMID 17399710 DOI: 10.1016/J.Febslet.2007.03.040  0.389
2007 Rachwal PA, Brown T, Fox KR. Effect of G-tract length on the topology and stability of intramolecular DNA quadruplexes. Biochemistry. 46: 3036-3044. PMID 17311417 DOI: 10.1021/Bi062118J  0.32
2007 Thompson A, Prescott M, Chelebi N, Smith J, Brown T, Schmidt G. Electrospray ionisation-cleavable tandem nucleic acid mass tag-peptide nucleic acid conjugates: synthesis and applications to quantitative genomic analysis using electrospray ionisation-MS/MS. Nucleic Acids Research. 35: e28. PMID 17259215 DOI: 10.1093/Nar/Gkl1123  0.355
2007 Yang Q, Gale N, Oton CJ, Li F, Vaughan A, Saito R, Nandhakumar IS, Tang Z, Cheng H, Brown T, Loh WH. A Raman probe for selective wrapping of single-walled carbon nanotubes by DNA Nanotechnology. 18: 405706. DOI: 10.1088/0957-4484/18/40/405706  0.374
2007 Xiao Q, Ranasinghe RT, Tang AM, Brown T. Naphthalenyl- and anthracenyl-ethynyl dT analogues as base discriminating fluorescent nucleosides and intramolecular energy transfer donors in oligonucleotide probes Tetrahedron. 63: 3483-3490. DOI: 10.1016/J.Tet.2006.10.090  0.333
2007 Tumpane J, Sandin P, Kumar R, Powers VEC, Lundberg EP, Gale N, Baglioni P, Lehn JM, Albinsson B, Lincoln P, Wilhelmsson LM, Brown T, Nordén B. Addressable high-information-density DNA nanostructures Chemical Physics Letters. 440: 125-129. DOI: 10.1016/J.Cplett.2007.04.018  0.434
2007 Yang Q, Gale N, Oton CJ, Li H, Nandhakumar IS, Tang Z, Brown T, Loh WH. Deuterated water as super solvent for short carbon nanotubes wrapped by DNA Carbon. 45: 2701-2703. DOI: 10.1016/J.Carbon.2007.08.014  0.328
2006 Li H, Broughton-Head VJ, Peng G, Powers VEC, Ovens MJ, Fox KR, Brown T. Triplex staples: DNA double-strand cross-linking at internal and terminal sites using psoralen-containing triplex-forming oligonucleotides Bioconjugate Chemistry. 17: 1561-1567. PMID 17105237 DOI: 10.1021/Bc0601875  0.423
2006 Fox KR, Brown T. An extra dimension in nucleic acid sequence recognition. Quarterly Reviews of Biophysics. 38: 311-20. PMID 16737560 DOI: 10.1017/S0033583506004197  0.402
2006 Rusling DA, Brown T, Fox KR. DNA triple-helix formation at target sites containing duplex mismatches Biophysical Chemistry. 123: 134-140. PMID 16735088 DOI: 10.1016/J.Bpc.2006.04.016  0.435
2006 Hampshire AJ, Khairallah H, Khalaf AI, Ebrahimabadi AH, Waigh RD, Suckling CJ, Brown T, Fox KR. DNA sequence recognition by an imidazole-containing isopropyl-substituted thiazole polyamide (thiazotropsin B). Bioorganic & Medicinal Chemistry Letters. 16: 3469-74. PMID 16644214 DOI: 10.1016/J.Bmcl.2006.04.007  0.415
2005 Ranasinghe RT, Brown T. Fluorescence based strategies for genetic analysis. Chemical Communications (Cambridge, England). 5487-502. PMID 16358042 DOI: 10.1039/B509522K  0.333
2005 Rusling DA, Le Strat L, Powers VEC, Broughton-Head VJ, Booth J, Lack O, Brown T, Fox KR. Combining nucleoside analogues to achieve recognition of oligopurine tracts by triplex-forming oligonucleotides at physiological pH Febs Letters. 579: 6616-6620. PMID 16293248 DOI: 10.1016/J.Febslet.2005.10.056  0.403
2005 Brown NM, Rachwal PA, Brown T, Fox KR. Exceptionally slow kinetics of the intramolecular quadruplex formed by the Oxytricha telomeric repeat. Organic & Biomolecular Chemistry. 3: 4153-7. PMID 16267597 DOI: 10.1039/B511706B  0.3
2005 Sandin P, Wilhelmsson LM, Lincoln P, Powers VEC, Brown T, Albinsson B. Fluorescent properties of DNA base analogue tC upon incorporation into DNA - Negligible influence of neighbouring bases on fluorescence quantum yield Nucleic Acids Research. 33: 5019-5025. PMID 16147985 DOI: 10.1093/Nar/Gki790  0.47
2005 Olsen PA, Randøl M, Luna L, Brown T, Krauss S. Genomic sequence correction by single-stranded DNA oligonucleotides: role of DNA synthesis and chemical modifications of the oligonucleotide ends. The Journal of Gene Medicine. 7: 1534-44. PMID 16025558 DOI: 10.1002/Jgm.804  0.453
2005 May JP, Brown LJ, van Delft I, Thelwell N, Harley K, Brown T. Synthesis and evaluation of a new non-fluorescent quencher in fluorogenic oligonucleotide probes for real-time PCR. Organic & Biomolecular Chemistry. 3: 2534-42. PMID 15999185 DOI: 10.1039/B504759E  0.403
2005 Dyadyusha L, Yin H, Jaiswal S, Brown T, Baumberg JJ, Booy FP, Melvin T. Quenching of CdSe quantum dot emission, a new approach for biosensing. Chemical Communications (Cambridge, England). 3201-3. PMID 15968371 DOI: 10.1039/B500664C  0.311
2005 Rusling DA, Powers VEC, Ranasinghe RT, Wang Y, Osborne SD, Brown T, Fox KR. Four base recognition by triplex-forming oligonucleotides at physiological pH Nucleic Acids Research. 33: 3025-3032. PMID 15911633 DOI: 10.1093/Nar/Gki625  0.331
2005 Ranasinghe RT, Rusling DA, Powers VEC, Fox KR, Brown T. Recognition of CG inversions in DNA triple helices by methylated 3H-pyrrolo[2,3-d]pyrimidin-2(7H)-one nucleoside analogues Chemical Communications. 2555-2557. PMID 15900324 DOI: 10.1039/B502325D  0.335
2005 Wang Y, Rusling DA, Powers VEC, Lack O, Osborne SD, Fox KR, Brown T. Stable recognition of TA interruptions by triplex forming oligonucleotides containing a novel nucleoside Biochemistry. 44: 5884-5892. PMID 15823047 DOI: 10.1021/Bi050013V  0.34
2005 Booth J, Brown T, Vadhia SJ, Lack O, Cummins WJ, Trent JO, Lane AN. Determining the origin of the stabilization of DNA by 5-aminopropynylation of pyrimidines. Biochemistry. 44: 4710-9. PMID 15779897 DOI: 10.1021/Bi047561D  0.402
2004 James PL, Le Strat L, Ellervik U, Bratwall C, Nordén B, Brown T, Fox KR. Effects of a hairpin polyamide on DNA melting: comparison with distamycin and Hoechst 33258. Biophysical Chemistry. 111: 205-12. PMID 15501563 DOI: 10.1016/J.Bpc.2004.06.001  0.349
2004 Engman KC, Sandin P, Osborne S, Brown T, Billeter M, Lincoln P, Nordén B, Albinsson B, Wilhelmsson LM. DNA adopts normal B-form upon incorporation of highly fluorescent DNA base analogue tC: NMR structure and UV-Vis spectroscopy characterization. Nucleic Acids Research. 32: 5087-95. PMID 15452275 DOI: 10.1093/Nar/Gkh844  0.497
2004 Osborne SD, Powers VEC, Rusling DA, Lack O, Fox KR, Brown T. Selectivity and affinity of triplex-forming oligonucleotides containing 2′-aminoethoxy-5-(3-aminoprop-1-ynyl)uridine for recognizing AT base pairs in duplex DNA Nucleic Acids Research. 32: 4439-4447. PMID 15317869 DOI: 10.1093/Nar/Gkh776  0.457
2004 Yin HB, Brown T, Wilkinson JS, Eason RW, Melvin T. Submicron patterning of DNA oligonucleotides on silicon. Nucleic Acids Research. 32: e118. PMID 15314186 DOI: 10.1093/Nar/Gnh113  0.365
2004 James PL, Merkina EE, Khalaf AI, Suckling CJ, Waigh RD, Brown T, Fox KR. DNA sequence recognition by an isopropyl substituted thiazole polyamide. Nucleic Acids Research. 32: 3410-7. PMID 15247333 DOI: 10.1093/Nar/Gkh666  0.425
2003 Keppler MD, James PL, Neidle S, Brown T, Fox KR. DNA sequence specificity of triplex-binding ligands European Journal of Biochemistry. 270: 4982-4992. PMID 14653824 DOI: 10.1046/J.1432-1033.2003.03901.X  0.329
2003 Anderson E, Brown T, Picken D. Novel photocleavable universal support for oligonucleotide synthesis. Nucleosides, Nucleotides & Nucleic Acids. 22: 1403-1406. PMID 14565429 DOI: 10.1081/Ncn-120022996  0.343
2003 James PL, Brown T, Fox KR. Thermodynamic and kinetic stability of intermolecular triple helices containing different proportions of C+·GC and T·AT triplets Nucleic Acids Research. 31: 5598-5606. PMID 14500823 DOI: 10.1093/Nar/Gkg782  0.318
2003 McKeen CM, Brown LJ, Nicol JT, Mellor JM, Brown T. Synthesis of fluorophore and quencher monomers for use in scorpion primers and nucleic acid structural probes. Organic & Biomolecular Chemistry. 1: 2267-75. PMID 12945696 DOI: 10.1039/B301859H  0.371
2003 Gyi JI, Gao D, Conn GL, Trent JO, Brown T, Lane AN. The solution structure of a DNA*RNA duplex containing 5-propynyl U and C; comparison with 5-Me modifications. Nucleic Acids Research. 31: 2683-93. PMID 12736318 DOI: 10.1093/Nar/Gkg356  0.657
2003 Vinje J, Parkinson JA, Sadler PJ, Brown T, Sletten E. Sequence-selective metalation of double-helical oligodeoxyribonucleotides with PtII, MnII, and ZnII ions. Chemistry (Weinheim An Der Bergstrasse, Germany). 9: 1620-30. PMID 12658661 DOI: 10.1002/Chem.200390186  0.31
2003 Bunting KA, Roe SM, Headley A, Brown T, Savva R, Pearl LH. Crystal structure of the Escherichia coli dcm very-short-patch DNA repair endonuclease bound to its reaction product-site in a DNA superhelix. Nucleic Acids Research. 31: 1633-9. PMID 12626704 DOI: 10.1093/Nar/Gkg273  0.419
2003 Brown J, Brown T, Fox KR. Cleavage of fragments containing DNA mismatches by enzymic and chemical probes. The Biochemical Journal. 371: 697-708. PMID 12558499 DOI: 10.1042/Bj20021847  0.341
2002 Pinheiro P, Scarlett G, Rodger A, Rodger PM, Murray A, Brown T, Newbury SF, McClellan JA. Structures of CUG repeats in RNA. Potential implications for human genetic diseases. The Journal of Biological Chemistry. 277: 35183-90. PMID 12077125 DOI: 10.1074/Jbc.M202235200  0.375
2002 Sollogoub M, Darby RA, Cuenoud B, Brown T, Fox KR. Stable DNA triple helix formation using oligonucleotides containing 2'-aminoethoxy,5-propargylamino-U. Biochemistry. 41: 7224-31. PMID 12044153 DOI: 10.1021/Bi020164N  0.64
2002 Darby RA, Sollogoub M, McKeen C, Brown L, Risitano A, Brown N, Barton C, Brown T, Fox KR. High throughput measurement of duplex, triplex and quadruplex melting curves using molecular beacons and a LightCycler. Nucleic Acids Research. 30: e39. PMID 11972354 DOI: 10.1093/Nar/30.9.E39  0.684
2002 Sollogoub M, Fox KR, Powers VEC, Brown T. First synthesis of 1-deazacytidine, the C-nucleoside analogue of cytidine Tetrahedron Letters. 43: 3121-3123. DOI: 10.1016/S0040-4039(02)00481-1  0.559
2001 French DJ, Archard CL, Brown T, McDowell DG. HyBeacon probes: a new tool for DNA sequence detection and allele discrimination. Molecular and Cellular Probes. 15: 363-74. PMID 11851380 DOI: 10.1006/Mcpr.2001.0384  0.43
2001 Solinas A, Brown LJ, McKeen C, Mellor JM, Nicol J, Thelwell N, Brown T. Duplex Scorpion primers in SNP analysis and FRET applications. Nucleic Acids Research. 29: E96. PMID 11600715 DOI: 10.1093/Nar/29.20.E96  0.316
2001 Brown J, Brown T, Fox KR. Affinity of mismatch-binding protein MutS for heteroduplexes containing different mismatches. Biochemical Journal. 354: 627-633. DOI: 10.1042/Bj3540627  0.35
2001 Ranasinghe RT, Brown LJ, Brown T. Linear fluorescent oligonucleotide probes with an acridine quencher generate a signal upon hybridisation Chemical Communications. 1: 1480-1481. DOI: 10.1039/B104421B  0.308
2000 Rösler A, Panayotou G, Hornby DP, Barlow T, Brown T, Pearl LH, Savva R, Blackburn GM. The mechanism of DNA repair by uracil-DNA glycosylase: studies using nucleotide analogues. Nucleosides, Nucleotides & Nucleic Acids. 19: 1505-16. PMID 11200255 DOI: 10.1080/15257770008045442  0.464
2000 Parkinson JA, Chen Y, del Socorro Murdoch P, Guo Z, Berners-Price SJ, Brown T, Sadler PJ. Sequence-dependent bending of DNA induced by cisplatin: NMR structures of an A.T-rich 14-mer duplex. Chemistry (Weinheim An Der Bergstrasse, Germany). 6: 3636-44. PMID 11072829 DOI: 10.1002/1521-3765(20001002)6:19<3636::Aid-Chem3636>3.0.Co;2-W  0.448
2000 Fox KR, Allinson SL, Sahagun-Krause H, Brown T. Recognition of GT mismatches by Vsr mismatch endonuclease. Nucleic Acids Research. 28: 2535-2540. PMID 10871403 DOI: 10.1093/Nar/28.13.2535  0.352
2000 Sollogoub M, Dominguez B, Fox KR, Brown T. Synthesis of a novel bis-amino-modified thymidine monomer for use in DNA triplex stabilisation Chemical Communications. 2315-2316. DOI: 10.1039/B006268P  0.66
2000 Brown LJ, Cummins J, Hamilton A, Brown T. Molecular beacons attached to glass beads fluoresce upon hybridisation to target DNA Chemical Communications. 621-622. DOI: 10.1039/B000389L  0.354
1999 Barrett TE, Schärer OD, Savva R, Brown T, Jiricny J, Verdine GL, Pearl LH. Crystal structure of a thwarted mismatch glycosylase DNA repair complex. The Embo Journal. 18: 6599-609. PMID 10581234 DOI: 10.1093/Emboj/18.23.6599  0.433
1999 Keppler MD, McKeen CM, Zegrocka O, Strekowski L, Brown T, Fox KR. DNA triple helix stabilisation by covalent attachment of a triplex-specific ligand. Biochimica Et Biophysica Acta. 1447: 137-45. PMID 10542311 DOI: 10.1016/S0167-4781(99)00114-1  0.369
1999 Gowers DM, Bijapur J, Brown T, Fox KR. DNA triple helix formation at target sites containing several pyrimidine interruptions: stabilization by protonated cytosine or 5-(1-propargylamino)dU. Biochemistry. 38: 13747-13758. PMID 10521282 DOI: 10.1021/Bi9911637  0.333
1999 Whitcombe D, Theaker J, Guy SP, Brown T, Little S. Detection of PCR products using self-probing amplicons and fluorescence. Nature Biotechnology. 17: 804-7. PMID 10429248 DOI: 10.1038/11751  0.304
1999 Asensio JL, Brown T, Lane AN. Solution conformation of a parallel DNA triple helix with 5′ and 3′ triplex–duplex junctions Structure. 7: 1-11. PMID 10368268 DOI: 10.1016/S0969-2126(99)80004-5  0.454
1999 Bijapur J, Keppler MD, Bergqvist S, Brown T, Fox KR. 5-(1-propargylamino)-2′-deoxyuridine (UP): A novel thymidine analogue for generating DNA triplexes with increased stability Nucleic Acids Research. 27: 1802-1809. PMID 10101187 DOI: 10.1093/Nar/27.8.1802  0.347
1999 Conn GL, Brown T, Leonard GA. The crystal structure of the RNA/DNA hybrid r(GAAGAGAAGC). d(GCTTCTCTTC) shows significant differences to that found in solution. Nucleic Acids Research. 27: 555-61. PMID 9862980 DOI: 10.1093/Nar/27.2.555  0.694
1999 Asensio JL, Carr R, Brown T, Lane AN. Conformational And Thermodynamic Properties Of Parallel Intramolecular Triple Helices Containing A Dna, Rna, Or 2'-Omedna Third Strand Journal of the American Chemical Society. 121: 11063-11070. DOI: 10.1021/Ja991949S  0.435
1999 Chen Y, Parkinson JA, Guo Z, Brown T, Sadler PJ. A New Platinum Anticancer Drug Forms a Highly Stereoselective Adduct with Duplex DNA Angewandte Chemie International Edition. 38: 2060-2063. DOI: 10.1002/(Sici)1521-3773(19990712)38:13/14<2060::Aid-Anie2060>3.0.Co;2-J  0.391
1999 Chen Y, Parkinson JA, Guo Z, Brown T, Sadler PJ. Ein neues Platin-Krebsmedikament bildet hochstereoselektiv ein Addukt mit Duplex-DNA Angewandte Chemie. 111: 2192-2196. DOI: 10.1002/(Sici)1521-3757(19990712)111:13/14<2192::Aid-Ange2192>3.0.Co;2-2  0.435
1998 Chamberlain D, Keeley A, Aslam M, Arenas-Licea J, Brown T, Tsaneva IR, Perkins SJ. A synthetic holliday junction is sandwiched between two tetrameric Mycobacterium leprae RuvA structures in solution: new insights from neutron scattering contrast variation and modelling. Journal of Molecular Biology. 284: 385-400. PMID 9813125 DOI: 10.1006/Jmbi.1998.2177  0.394
1998 Roe SM, Barlow T, Brown T, Oram M, Keeley A, Tsaneva IR, Pearl LH. Crystal structure of an octameric RuvA-Holliday junction complex. Molecular Cell. 2: 361-72. PMID 9774974 DOI: 10.1016/S1097-2765(00)80280-4  0.444
1998 Barrett TE, Savva R, Barlow T, Brown T, Jiricny J, Pearl LH. Structure of a DNA base-excision product resembling a cisplatin inter-strand adduct. Nature Structural & Molecular Biology. 5: 697-701. PMID 9699633 DOI: 10.1038/1394  0.458
1998 Asensio JL, Brown T, Lane AN. Comparison of the solution structures of intramolecular DNA triple helices containing adjacent and non-adjacent CG·C+ triplets Nucleic Acids Research. 26: 3677-3686. PMID 9685482 DOI: 10.1093/Nar/26.16.3677  0.363
1998 Gyi JI, Lane AN, Conn GL, Brown T. The orientation and dynamics of the C2'-OH and hydration of RNA and DNA.RNA hybrids. Nucleic Acids Research. 26: 3104-10. PMID 9628906 DOI: 10.1093/Nar/26.13.3104  0.685
1998 Barrett TE, Savva R, Panayotou G, Barlow T, Brown T, Jiricny J, Pearl LH. Crystal Structure of a G:T/U Mismatch-Specific DNA Glycosylase: Mismatch Recognition by Complementary-Strand Interactions Cell. 92: 117-129. PMID 9489705 DOI: 10.1016/S0092-8674(00)80904-6  0.476
1998 Asensio JL, Lane AN, Dhesi J, Bergqvist S, Brown T. The contribution of cytosine protonation to the stability of parallel DNA triple helices. Journal of Molecular Biology. 275: 811-822. PMID 9480771 DOI: 10.1006/Jmbi.1997.1520  0.341
1998 Gyi JI, Lane AN, Conn GL, Brown T. Solution structures of DNA.RNA hybrids with purine-rich and pyrimidine-rich strands: comparison with the homologous DNA and RNA duplexes. Biochemistry. 37: 73-80. PMID 9425027 DOI: 10.1021/Bi9719713  0.649
1998 Panayotou G, Brown T, Barlow T, Pearl LH, Savva R. Direct Measurement of the Substrate Preference of Uracil-DNA Glycosylase Journal of Biological Chemistry. 273: 45-50. PMID 9417045 DOI: 10.1074/Jbc.273.1.45  0.473
1998 Graham D, Parkinson JA, Brown T. DNA duplexes stabilized by modified monomer residues: synthesis and stability Journal of the Chemical Society-Perkin Transactions 1. 1998: 1131-1138. DOI: 10.1039/A707031D  0.467
1997 Bartley JP, Brown T, Lane AN. Solution conformation of an intramolecular DNA triplex containing a nonnucleotide linker: comparison with the DNA duplex. Biochemistry. 36: 14502-14511. PMID 9398169 DOI: 10.1021/Bi970710Q  0.407
1997 Bonifacio GF, Brown T, Conn GL, Lane AN. Comparison of the electrophoretic and hydrodynamic properties of DNA and RNA oligonucleotide duplexes. Biophysical Journal. 73: 1532-8. PMID 9284320 DOI: 10.1016/S0006-3495(97)78185-2  0.696
1997 Conte MR, Conn GL, Brown T, Lane AN. Conformational properties and thermodynamics of the RNA duplex r(CGCAAAUUUGCG)2: comparison with the DNA analogue d(CGCAAATTTGCG)2. Nucleic Acids Research. 25: 2627-34. PMID 9185574 DOI: 10.1093/Nar/25.13.2627  0.662
1997 Moraru-Allen AA, Cassidy S, Alvarez JA, Fox KR, Brown T, Lane AN. Coralyne has a preference for intercalation between TA-T triples in intramolecular DNA triple helices Nucleic Acids Research. 25: 1890-1896. PMID 9115354 DOI: 10.1093/Nar/25.10.1890  0.349
1997 Sutton DH, Conn GL, Brown T, Lane AN. The dependence of DNase I activity on the conformation of oligodeoxynucleotides. The Biochemical Journal. 481-6. PMID 9020884 DOI: 10.1042/Bj3210481  0.697
1997 Brown T, Hunter WN. Non-Watson-Crick base associations in DNA and RNA revealed by single crystal x-Ray diffraction methods: Mismatches, modified bases, and nonduplex DNA Biopolymers. 44: 91-103. DOI: 10.1002/(Sici)1097-0282(1997)44:1<91::Aid-Bip6>3.0.Co;2-V  0.477
1996 Conte MR, Conn GL, Brown T, Lane AN. Hydration of the RNA duplex r(CGCAAAUUUGCG)2 determined by NMR. Nucleic Acids Research. 24: 3693-9. PMID 8871546 DOI: 10.1093/Nar/24.19.3693  0.692
1996 Gyi JI, Conn GL, Lane AN, Brown T. Comparison of the thermodynamic stabilities and solution conformations of DNA.RNA hybrids containing purine-rich and pyrimidine-rich strands with DNA and RNA duplexes. Biochemistry. 35: 12538-48. PMID 8823191 DOI: 10.1021/Bi960948Z  0.716
1996 Finn PJ, Gibson NJ, Fallon R, Hamilton A, Brown T. Synthesis and properties of DNA-PNA chimeric oligomers. Nucleic Acids Research. 24: 3357-63. PMID 8811090 DOI: 10.1093/Nar/24.17.3357  0.479
1996 Boggon TJ, Hancox EL, McAuley-Hecht KE, Connolly BA, Hunter WN, Brown T, Walker RT, Leonard GA. The crystal structure analysis of d(CGCGAASSCGCG)2, a synthetic DNA dodecamer duplex containing four 4'-thio-2'-deoxythymidine nucleotides. Nucleic Acids Research. 24: 951-61. PMID 8600465 DOI: 10.1093/Nar/24.5.951  0.345
1996 Savva R, McAuley-Hecht K, Brown T, Pearl L. The structural basis of specific base-excision repair by uracil–DNA glycosylase Nature. 373: 487-493. PMID 7845459 DOI: 10.1038/373487A0  0.438
1995 Dautant A, D'estaintot BL, Gallois B, Brown T, Hunter WN. A trigonal form of the idarubicin:d(CGATCG) complex; crystal and molecular structure at 2.0 A resolution. Nucleic Acids Research. 23: 1710-1716. PMID 7784175 DOI: 10.1093/Nar/23.10.1710  0.31
1995 Cubie HA, Molyneaux PJ, Shearman MJ, Gryzbowski J, Brown T. Dot-blot hybridisation assay for detection of parvovirus B19 infections using synthetic oligonucleotides Molecular and Cellular Probes. 9: 59-65. PMID 7760862 DOI: 10.1016/S0890-8508(95)91037-9  0.363
1995 Cubie HA, Grzybowski J, Da Silva C, Duncan l, Brown T, Smith NM. Synthetic oligonucleotide cocktails as probes for detection of human parvovirus B19 Journal of Virological Methods. 53: 91-102. PMID 7635929 DOI: 10.1016/0166-0934(94)00179-K  0.353
1995 Leonard GA, Zhang S, Peterson MR, Harrop SJ, Helliwell JR, Cruse WB, d'Estaintot BL, Kennard O, Brown T, Hunter WN. Self-association of a DNA loop creates a quadruplex: crystal structure of d(GCATGCT) at 1.8 A resolution. Structure (London, England : 1993). 3: 335-40. PMID 7613864 DOI: 10.1016/S0969-2126(01)00165-4  0.472
1994 Leonard GA, McAuley-Hecht KE, Gibson NJ, Brown T, Watson WP, Hunter WN. Guanine-1,N6-ethenoadenine base pairs in the crystal structure of d(CGCGAATT(epsilon dA)GCG). Biochemistry. 33: 4755-61. PMID 8161534 DOI: 10.1021/Bi00182A002  0.342
1994 Lane A, Ebel S, Brown T. Properties of multiple G.A mismatches in stable oligonucleotide duplexes. Febs Journal. 220: 717-727. PMID 8143726 DOI: 10.1111/J.1432-1033.1994.Tb18672.X  0.346
1994 Ebel S, Brown T, Lane AN. Thermodynamic stability and solution conformation of tandem G · A mismatches in RNA and RNA · DNA hybrid duplexes Febs Journal. 220: 703-715. PMID 8143725 DOI: 10.1111/J.1432-1033.1994.Tb18671.X  0.444
1994 McAuley-Hecht KE, Leonard GA, Gibson NJ, Thomson JB, Watson WP, Hunter WN, Brown T. Crystal structure of a DNA duplex containing 8-hydroxydeoxyguanine-adenine base pairs. Biochemistry. 33: 10266-70. PMID 8068665 DOI: 10.1021/Bi00200A006  0.454
1994 Leonard GA, McAuley-Hecht KE, Ebel S, Lough DM, Brown T, Hunter WN. Crystal and molecular structure of r(CGCGAAUUAGCG): an RNA duplex containing two G(anti).A(anti) base pairs. Structure (London, England : 1993). 2: 483-94. PMID 7922026 DOI: 10.1016/S0969-2126(00)00049-6  0.357
1994 Hendry P, Moghaddam MJ, McCall MJ, Jennings PA, Ebel S, Brown T. Using linkers to investigate the spatial separation of the conserved nucleotides A9 and G12 in the hammerhead ribozyme. Biochimica Et Biophysica Acta. 1219: 405-12. PMID 7522573 DOI: 10.1016/0167-4781(94)90065-5  0.34
1994 Gibson NJ, Parkinson JA, Barlow T, Watson WP, Brown T. The stability of duplex DNA containing 3,N4-etheno-2′-deoxycytidine (εdC). A UV melting and high resolution 1H NMR study Journal of the Chemical Society, Chemical Communications. 2241-2242. DOI: 10.1039/C39940002241  0.418
1994 Leonard GA, Hunter WN, Brown T. Studies of the structure and stability of base pair mismatches, base pairs involving modified bases, and DNA-drug complexes Journal of Chemical Crystallography. 24: 5-15. DOI: 10.1007/Bf01665340  0.468
1993 Gallois B, d'Estaintot BL, Brown T, Hunter WN. The structure of an idarubicin-d(TGATCA) complex at high resolution. Acta Crystallographica Section D-Biological Crystallography. 49: 311-317. PMID 15299520 DOI: 10.1107/S0907444992009983  0.439
1993 Leonard GA, Hambley TW, McAuley-Hecht K, Brown T, Hunter WN. Anthracycline-DNA interactions at unfavourable base-pair triplet-binding sites: structures of d(CGGCCG)/daunomycin and d(TGGCCA)/adriamycin complexes. Acta Crystallographica. Section D, Biological Crystallography. 49: 458-67. PMID 15299505 DOI: 10.1107/S090744499300527X  0.386
1993 Lever C, Li X, Cosstick R, Ebel S, Brown T. Thermodynamic stability and drug-binding properties of oligodeoxyribonucleotide duplexes containing 3-deazaadenine:thymine base pairs. Nucleic Acids Research. 21: 1743-6. PMID 8493091 DOI: 10.1093/Nar/21.8.1743  0.34
1993 Grzybowski J, Will DW, Randall RE, Smith CA, Brown T. Synthesis and antibody-mediated detection of oligonucleotides containing multiple 2,4-dinitrophenyl reporter groups. Nucleic Acids Research. 21: 1705-12. PMID 8493087 DOI: 10.1093/Nar/21.8.1705  0.311
1993 Teigelkamp S, Ebel S, Will DW, Brown T, Beggs JD. Branched poly-labelled oligonucleotides: enhanced specificity of fork-shaped biotinylated oligoribonucleotides for antisense affinity selection. Nucleic Acids Research. 21: 4651-4652. PMID 8233810 DOI: 10.1093/Nar/21.19.4651  0.403
1993 Lane AN, Ebel S, Brown T. NMR assignments and solution conformation of the DNA · RNA hybrid duplex d(GTGAACTT) · r(AAGUUCAC) Febs Journal. 215: 297-306. PMID 7688302 DOI: 10.1111/J.1432-1033.1993.Tb18035.X  0.461
1993 Cruse WBT, Salisbury SA, Brown T, Cosstick R, Eckstein F, Kennard O. Chiral phosphorothioate analogues of B-DNA: The crystal structure of Rp-d¦Gp(S)CpGp(S)CpGp(S)C¦☆ Journal of Molecular Biology. 192: 891-905. DOI: 10.2210/Pdb1D97/Pdb  0.386
1992 Will DW, Pritchard CE, Brown T. The synthesis of oligonucleotides that contain 2,4-dinitrophenyl reporter groups Carbohydrate Research. 216: 315-322. PMID 1797383 DOI: 10.1016/0008-6215(92)84170-W  0.316
1992 Leonard GA, Brown T, Hunter WN. Anthracycline binding to DNA. High-resolution structure of d(TGTACA) complexed with 4'-epiadriamycin. European Journal of Biochemistry / Febs. 204: 69-74. PMID 1740157 DOI: 10.1111/J.1432-1033.1992.Tb16606.X  0.429
1992 d'Estaintot BL, Gallois B, Brown T, Hunter WN. The molecular structure of a 4'-epiadriamycin complex with d(TGATCA) at 1.7A resolution: comparison with the structure of 4'-epiadriamycin d(TGTACA) and d(CGATCG) complexes. Nucleic Acids Research. 20: 3561-3566. PMID 1641324 DOI: 10.1093/Nar/20.14.3561  0.355
1992 MacKellar C, Graham D, Will DW, Burgess S, Brown T. Synthesis and physical properties of anti-HIV antisense oligonucleotides bearing terminal lipophilic groups. Nucleic Acids Research. 20: 3411-3417. PMID 1630912 DOI: 10.1093/Nar/20.13.3411  0.384
1992 Borden KLB, Jenkins TC, Skelly JV, Brown T, Lane AN. Conformational properties of the G·G mismatch in d(CGCGAATTGGCG)2 determined by NMR Biochemistry. 31: 5411-5422. PMID 1606167 DOI: 10.1021/Bi00138A024  0.36
1992 Ebel S, Lane AN, Brown T. Very stable mismatch duplexes: structural and thermodynamic studies on tandem G.A mismatches in DNA. Biochemistry. 31: 12083-12086. PMID 1457405 DOI: 10.1021/Bi00163A017  0.334
1992 Leonard GA, Booth ED, Hunter WN, Brown T. The conformational variability of an adenosine.inosine base-pair in a synthetic DNA dodecamer. Nucleic Acids Research. 20: 4753-9. PMID 1408788 DOI: 10.1093/Nar/20.18.4753  0.367
1992 Brown T, Brown DJS. Purification of synthetic DNA. Methods in Enzymology. 211: 20-35. PMID 1406308 DOI: 10.1016/0076-6879(92)11004-3  0.414
1992 Leonard GA, Guy A, Brown T, Téoule R, Hunter WN. Conformation of guanine-8-oxoadenine base pairs in the crystal structure of d(CGCGAATT(O8A)GCG). Biochemistry. 31: 8415-20. PMID 1390625 DOI: 10.1021/Bi00151A004  0.336
1992 Lane A, Martin SR, Ebel S, Brown T. Solution conformation of a deoxynucleotide containing tandem G.A mismatched base pairs and 3'-overhanging ends in d(GTGAACTT)2. Biochemistry. 31: 12087-12095. PMID 1333792 DOI: 10.1021/Bi00163A018  0.336
1992 Brown T, Kennard O. Structural basis of DNA mutagenesis Current Opinion in Structural Biology. 2: 354-360. DOI: 10.1016/0959-440X(92)90225-V  0.455
1991 Lane AN, Jenkins TC, Brown T, Neidle S. Interaction of berenil with the EcoRI dodecamer d(CGCGAATTCGCG)2 in solution studied by NMR. Biochemistry. 30: 1372-85. PMID 1991117 DOI: 10.1021/Bi00219A030  0.383
1991 Lane AN, Jenkins TC, Brown DJS, Brown T. N.m.r. determination of the solution conformation and dynamics of the A·G mismatch in the d(CGCAAATTGGCG)2 dodecamer Biochemical Journal. 281: 269-281. PMID 1536663 DOI: 10.1042/Bj2810880  0.314
1990 Leonard GA, Thomson J, Watson WP, Brown T. High-resolution structure of a mutagenic lesion in DNA. Proceedings of the National Academy of Sciences of the United States of America. 87: 9573-6. PMID 2263612 DOI: 10.1073/Pnas.87.24.9573  0.348
1990 Leonard GA, Booth ED, Brown T. Structural and thermodynamic studies on the adenine.guanine mismatch in B-DNA. Nucleic Acids Research. 18: 5617-23. PMID 2216754 DOI: 10.1093/Nar/18.19.5617  0.405
1990 Brown T, Leonard GA, Booth ED, Kneale G. Influence of pH on the conformation and stability of mismatch base-pairs in DNA. Journal of Molecular Biology. 212: 437-40. PMID 2182883 DOI: 10.1016/0022-2836(90)90320-L  0.339
1990 Brown D, Sanderson M, Skelly J, Jenkins T, Brown T, Garman E, Stuart D, Neidle S. Crystal structure of a berenil-dodecanucleotide complex: the role of water in sequence-specific ligand binding. The Embo Journal. 9: 1329-1334. DOI: 10.1002/J.1460-2075.1990.Tb08242.X  0.326
1989 Cruse WB, Aymani J, Kennard O, Brown T, Jack AG, Leonard GA. Refined crystal structure of an octanucleotide duplex with I.T. mismatched base pairs. Nucleic Acids Research. 17: 55-72. PMID 2911488 DOI: 10.1093/Nar/17.1.55  0.377
1989 Brown T, Leonard GA, Booth ED, Chambers J. Crystal structure and stability of a DNA duplex containing A(anti).G(syn) base-pairs. Journal of Molecular Biology. 207: 455-7. PMID 2754734 DOI: 10.1016/0022-2836(89)90268-4  0.408
1987 Corfield PW, Hunter WN, Brown T, Robinson P, Kennard O. Inosine.adenine base pairs in a B-DNA duplex. Nucleic Acids Research. 15: 7935-49. PMID 3671069 DOI: 10.1093/Nar/15.19.7935  0.385
1987 Hunter WN, Brown T, Kennard O. Structural features and hydration of a dodecamer duplex containing two C.A mispairs Nucleic Acids Research. 15: 6589-6605. PMID 3627999 DOI: 10.1093/Nar/15.16.6589  0.335
1987 Hunter WN, Brown T, Kneale G, Anand NN, Rabinovich D, Kennard O. The structure of guanosine-thymidine mismatches in B-DNA at 2.5-A resolution. The Journal of Biological Chemistry. 262: 9962-70. PMID 3611072 DOI: 10.2210/Pdb113D/Pdb  0.351
1987 Cruse WB, Salisbury SA, Brown T, Cosstick R, Eckstein F, Kennard O. Chiral phosphorothioate analogues of B-DNA. The crystal structure of Rp-d[Gp(S)CpGp(S)CpGp(S)C]. Journal of Molecular Biology. 192: 891-905. PMID 3108513 DOI: 10.1016/0022-2836(86)90035-5  0.406
1986 Hunter WN, Brown T, Anand NN, Kennard O. Structure of an adenine˙cytosine base pair in DNA and its implications for mismatch repair Nature. 320: 552-555. PMID 3960137 DOI: 10.1038/320552A0  0.468
1986 Brown T, Kneale G, Hunter WN, Kennard O. Structural characterisation of the bromouracil.guanine base pair mismatch in a Z-DNA fragment Nucleic Acids Research. 14: 1801-1809. PMID 3951996 DOI: 10.1093/Nar/14.4.1801  0.368
1986 Hunter WN, Kneale G, Brown T, Rabinovich D, Kennard O. Refined crystal structure of an octanucleotide duplex with G . T mismatched base-pairs. Journal of Molecular Biology. 190: 605-18. PMID 3783714 DOI: 10.1016/0022-2836(86)90246-9  0.368
1986 McCall M, Brown T, Hunter WN, Kennard O. The crystal structure of d(GGATGGGAG): An essential part of the binding site for transcription factor IIIA Nature. 322: 661-664. PMID 3748146 DOI: 10.1038/322661A0  0.366
1986 Brown T, Hunter WN, Kneale G, Kennard O. Molecular structure of the G.A base pair in DNA and its implications for the mechanism of transversion mutations. Proceedings of the National Academy of Sciences of the United States of America. 83: 2402-2406. PMID 3458205 DOI: 10.1073/Pnas.83.8.2402  0.381
1986 Hunter WN, Brown T, Kennard O. Structural features and hydration of d(C-G-C-G-A-A-T-T-A-G-C-G); a double helix containing two G.A mispairs. Journal of Biomolecular Structure & Dynamics. 4: 173-191. PMID 3271438 DOI: 10.1080/07391102.1986.10506338  0.312
1985 Kneale G, Brown T, Kennard O, Rabinovich D. G . T base-pairs in a DNA helix: the crystal structure of d(G-G-G-G-T-C-C-C). Journal of Molecular Biology. 186: 805-14. PMID 4093986 DOI: 10.1016/0022-2836(85)90398-5  0.339
1985 Reid DG, Salisbury SA, Brown T, Williams DH. Conformations of two duplex forms of d(TCGA) in slow-exchange equilibrium characterized by NMR. Biochemistry. 24: 4325-32. PMID 4052399 DOI: 10.1021/Bi00337A011  0.41
1985 McCall M, Brown T, Kennard O. The crystal structure of d(G-G-G-G-C-C-C-C) a model for poly(dG) · poly(dC) Journal of Molecular Biology. 183: 385-396. PMID 4020865 DOI: 10.1016/0022-2836(85)90009-9  0.324
1985 Brown T, Kennard O, Kneale G, Rabinovich D. High-resolution structure of a DNA helix containing mismatched base pairs. Nature. 315: 604-6. PMID 4010774 DOI: 10.1038/315604A0  0.442
1985 Brown T, Kennard O, Kneale G. Base-Pair Mismatch in DNA at 2.3A Resolution Nucleosides, Nucleotides & Nucleic Acids. 4: 255-255. DOI: 10.1080/07328318508077877  0.423
1983 Reid DG, Salisbury SA, Brown T, Williams DH, Vasseur JJ, Rayner B, Imbach JL. Use of inter-proton nuclear Overhauser effects to assign the nuclear magnetic resonance spectra of oligodeoxynucleotide and hybrid duplexes in aqueous solution. European Journal of Biochemistry. 135: 307-14. PMID 6309522 DOI: 10.1111/J.1432-1033.1983.Tb07654.X  0.333
1983 Brown T, Shaw G, Durant GJ. Purines, pyrimidines, and imidazoles. Part 58. Synthesis and reactions of some imidazole-2,4-dicarboxylic acid derivatives Journal of the Chemical Society-Perkin Transactions 1. 14: 809-811. DOI: 10.1039/P19830000809  0.583
1980 Brown T, Shaw G, Durant GJ. Purines, pyrimidines, and imidazoles. Part 53. Synthesis of some 5-halogeno-analogues of metiamide and cimetidine Journal of the Chemical Society-Perkin Transactions 1. 12: 2310-2315. DOI: 10.1039/P19800002310  0.595
1979 Brown T, Kadir K, Mackenzie G, Shaw G. Purines, pyrimidines, and imidazoles. Part 51. New syntheses of some 5-alkyl- and 5-dialkyl-aminoimidazoles. 3-Alkylimidazolium nucleosides and 3-alkylpurines Journal of the Chemical Society-Perkin Transactions 1. 11: 3107-3112. DOI: 10.1039/P19790003107  0.592
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