Alain R.M. Townsend - Publications

Affiliations: 
Weatherall Institute of Molecular Medicine University of Oxford, Oxford, United Kingdom 

65 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Howarth M, Rahikainen R, Rijal P, Tan T, Draper S, Townsend A, Wu HJ, Bowden T, Andersson AM, Barrett J. Overcoming Symmetry Mismatch in Vaccine Nanoassembly via Spontaneous Amidation. Angewandte Chemie (International Ed. in English). PMID 32886840 DOI: 10.1002/Anie.202009663  0.363
2020 Miao X, Luo Y, Huang X, Lee SMY, Yuan Z, Tang Y, Chen L, Wang C, Wu F, Xu Y, Jiang W, Gao W, Song X, Yan Y, Pang T, ... ... Townsend A, et al. A novel biparatopic hybrid antibody-ACE2 fusion that blocks SARS-CoV-2 infection: implications for therapy. Mabs. 12: 1804241. PMID 32804015 DOI: 10.1080/19420862.2020.1804241  0.358
2020 McNee A, Smith TRF, Holzer B, Clark B, Bessell E, Guibinga G, Brown H, Schultheis K, Fisher P, Ramos S, Nunez A, Bernard M, Graham S, Martini V, Chrun T, ... ... Townsend A, et al. Establishment of a Pig Influenza Challenge Model for Evaluation of Monoclonal Antibody Delivery Platforms. Journal of Immunology (Baltimore, Md. : 1950). PMID 32591390 DOI: 10.4049/Jimmunol.2000429  0.329
2020 Huo J, Zhao Y, Ren J, Zhou D, Duyvesteyn HME, Ginn HM, Carrique L, Malinauskas T, Ruza RR, Shah PNM, Tan TK, Rijal P, Coombes N, Bewley KR, Tree JA, ... ... Townsend A, et al. Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike. Cell Host & Microbe. PMID 32585135 DOI: 10.1016/J.Chom.2020.06.010  0.33
2018 Tungatt K, Dolton G, Morgan SB, Attaf M, Fuller A, Whalley T, Hemmink JD, Porter E, Szomolay B, Montoya M, Hammond JA, Miles JJ, Cole DK, Townsend A, Bailey M, et al. Induction of influenza-specific local CD8 T-cells in the respiratory tract after aerosol delivery of vaccine antigen or virus in the Babraham inbred pig. Plos Pathogens. 14: e1007017. PMID 29772011 DOI: 10.1371/Journal.Ppat.1007017  0.463
2018 Morgan SB, Holzer B, Hemmink JD, Salguero FJ, Schwartz JC, Agatic G, Cameroni E, Guarino B, Porter E, Rijal P, Townsend A, Charleston B, Corti D, Tchilian E. Therapeutic Administration of Broadly Neutralizing FI6 Antibody Reveals Lack of Interaction Between Human IgG1 and Pig Fc Receptors. Frontiers in Immunology. 9: 865. PMID 29740451 DOI: 10.3389/Fimmu.2018.00865  0.351
2018 Holzer B, Morgan SB, Matsuoka Y, Edmans M, Salguero FJ, Everett H, Brookes SM, Porter E, MacLoughlin R, Charleston B, Subbarao K, Townsend A, Tchilian E. Comparison of Heterosubtypic Protection in Ferrets and Pigs Induced by a Single-Cycle Influenza Vaccine. Journal of Immunology (Baltimore, Md. : 1950). PMID 29703861 DOI: 10.4049/Jimmunol.1800142  0.347
2017 Xiao J, Rijal P, Schimanski L, Tharkeshwar AK, Wright E, Annaert W, Townsend A. Characterization of an influenza virus pseudotyped with Ebolavirus glycoprotein. Journal of Virology. PMID 29212933 DOI: 10.1128/Jvi.00941-17  0.351
2015 Baz M, Boonnak K, Paskel M, Santos C, Powell T, Townsend A, Subbarao K. Nonreplicating influenza A virus vaccines confer broad protection against lethal challenge. Mbio. 6: e01487-15. PMID 26489862 DOI: 10.1128/Mbio.01487-15  0.322
2012 Powell TJ, Silk JD, Sharps J, Fodor E, Townsend AR. Pseudotyped influenza A virus as a vaccine for the induction of heterotypic immunity. Journal of Virology. 86: 13397-406. PMID 23015719 DOI: 10.1128/Jvi.01820-12  0.362
2000 Drakesmith H, Townsend A. The structure and function of HFE. Bioessays. 22: 595-598. PMID 10878571 DOI: 10.1002/1521-1878(200007)22:7<595::Aid-Bies1>3.0.Co;2-E  0.425
1999 Glithero A, Tormo J, Haurum JS, Arsequell G, Valencia G, Edwards J, Springer S, Townsend A, Pao YL, Wormald M, Dwek RA, Jones EY, Elliott T. Crystal structures of two H-2Db/glycopeptide complexes suggest a molecular basis for CTL cross-reactivity. Immunity. 10: 63-74. PMID 10023771 DOI: 10.1016/S1074-7613(00)80007-2  0.626
1998 Bastin JM, Jones M, O'Callaghan CA, Schimanski L, Mason DY, Townsend AR. Kupffer cell staining by an HFE-specific monoclonal antibody: implications for hereditary haemochromatosis. British Journal of Haematology. 103: 931-41. PMID 9886303 DOI: 10.1046/J.1365-2141.1998.01102.X  0.399
1998 Mukherjee S, Trivedi P, Dorfman DM, Klein G, Townsend A. Murine cytotoxic T lymphocytes recognize an epitope in an EBNA-1 fragment, but fail to lyse EBNA-1-expressing mouse cells. The Journal of Experimental Medicine. 187: 445-50. PMID 9449725 DOI: 10.1084/Jem.187.3.445  0.476
1997 Cerundolo V, Benham A, Braud V, Mukherjee S, Gould K, Macino B, Neefjes J, Townsend A. The proteasome-specific inhibitor lactacystin blocks presentation of cytotoxic T lymphocyte epitopes in human and murine cells European Journal of Immunology. 27: 336-341. PMID 9022037 DOI: 10.1002/Eji.1830270148  0.499
1996 Elliott T, Bodmer H, Townsend A. Recognition of out-of-frame major histocompatibility complex class I-restricted epitopes in vivo. European Journal of Immunology. 26: 1175-1179. PMID 8647184 DOI: 10.1002/Eji.1830260532  0.412
1995 Mamalaki C, Murdjeva M, Tolaini M, Norton T, Chandler P, Townsend A, Simpson E, Kioussis D. Tolerance in TCR/cognate antigen double-transgenic mice mediated by incomplete thymic deletion and peripheral receptor downregulation. Developmental Immunology. 4: 299-315. PMID 8924765 DOI: 10.1155/1995/54219  0.324
1995 Cerundolo V, Kelly A, Elliott T, Trowsdale J, Townsend A. Genes encoded in the major histocompatibility complex affecting the generation of peptides for TAP transport. European Journal of Immunology. 25: 554-562. PMID 7875220 DOI: 10.1002/Eji.1830250238  0.491
1995 Clover LM, Sargent IL, Townsend A, Tampé R, Redman CWG. Expression of TAP1 by human trophoblast. European Journal of Immunology. 25: 543-548. PMID 7875218 DOI: 10.1002/Eji.1830250236  0.442
1995 Elliott T, Willis A, Cerundolo V, Townsend A. Processing of major histocompatibility class I-restricted antigens in the endoplasmic reticulum. Journal of Experimental Medicine. 181: 1481-1491. PMID 7699331 DOI: 10.1084/Jem.181.4.1481  0.475
1995 Blake NW, Kettle S, Law KM, Gould K, Bastin J, Townsend AR, Smith GL. Vaccinia virus serpins B13R and B22R do not inhibit antigen presentation to class I-restricted cytotoxic T lymphocytes. The Journal of General Virology. 76: 2393-8. PMID 7561783 DOI: 10.1099/0022-1317-76-9-2393  0.422
1994 Townsend A, Öhlén C, Rogers M, Edwards J, Mukherjee S, Bastin J. Source of unique tumour antigens Nature. 371: 662-662. PMID 7935811 DOI: 10.1038/371662A0  0.302
1994 van der Bruggen P, Bastin J, Gajewski T, Coulie PG, Boël P, De Smet C, Traversari C, Townsend A, Boon T. A peptide encoded by human gene MAGE-3 and presented by HLA-A2 induces cytolytic T lymphocytes that recognize tumor cells expressing MAGE-3. European Journal of Immunology. 24: 3038-43. PMID 7805731 DOI: 10.1002/Eji.1830241218  0.424
1993 Townsend A, Trowsdale J. The transporters associated with antigen presentation. Seminars in Cell Biology. 4: 53-61. PMID 8453065 DOI: 10.1006/Scel.1993.1007  0.391
1993 Elvin J, Potter C, Elliott T, Cerundolo V, Townsend A. A method to quantify binding of unlabeled peptides to class I MHC molecules and detect their allele specificity Journal of Immunological Methods. 158: 161-171. PMID 7679131 DOI: 10.1016/0022-1759(93)90210-X  0.455
1992 Elliott T, Elvin J, Cerundolo V, Allen H, Townsend A. Structural requirements for the peptide-induced conformational change of free major histocompatibility complex class I heavy chains European Journal of Immunology. 22: 2085-2091. PMID 1639105 DOI: 10.1002/Eji.1830220819  0.428
1992 Kleijmeer MJ, Kelly A, Geuze HJ, Slot JW, Townsend A, Trowsdale J. Location of MHC-encoded transporters in the endoplasmic reticulum and cis-Golgi. Nature. 357: 342-4. PMID 1589036 DOI: 10.1038/357342A0  0.47
1992 Spies T, Cerundolo V, Colonna M, Cresswell P, Townsend A, DeMars R. Presentation of viral antigen by MHC class I molecules is dependent on a putative peptide transporter heterodimer. Nature. 355: 644-6. PMID 1538752 DOI: 10.1038/355644A0  0.499
1992 Kelly A, Powis SH, Kerr LA, Mockridge I, Elliott T, Bastin J, Uchanska-Ziegler B, Ziegler A, Trowsdale J, Townsend A. Assembly and function of the two ABC transporter proteins encoded in the human major histocompatibility complex Nature. 355: 641-644. PMID 1538751 DOI: 10.1038/355641A0  0.469
1992 Sibille C, Gould K, Hämmerling G, Townsend A. A defect in the presentation of intracellular viral antigens is restored by interferon-γ in cell lines with impaired major histocompatibility complex class I assembly European Journal of Immunology. 22: 433-440. PMID 1537379 DOI: 10.1002/Eji.1830220222  0.483
1992 Cerundolo V, Elliott T, Elvin J, Bastin J, Townsend A. Association of the human invariant chain with H-2 Db class I molecules. European Journal of Immunology. 22: 2243-8. PMID 1516617 DOI: 10.1002/Eji.1830220910  0.439
1992 Elliott T, Cerundolo V, Townsend A. Short peptides assist the folding of free class I heavy chains in solution. European Journal of Immunology. 22: 3121-3125. PMID 1280223 DOI: 10.1002/Eji.1830221214  0.463
1991 Elliott T, Cerundolo V, Elvin J, Townsend A. Peptide-induced conformational change of the class I heavy chain Nature. 351: 402-406. PMID 2034289 DOI: 10.1038/351402A0  0.413
1991 Aosai F, Ohlen C, Ljunggren HG, Höglund P, Franksson L, Ploegh H, Townsend A, Kärre K, Stauss HJ. Different types of allospecific CTL clones identified by their ability to recognize peptide loading-defective target cells. European Journal of Immunology. 21: 2767-74. PMID 1936122 DOI: 10.1002/Eji.1830211118  0.479
1991 Elvin J, Cerundolo V, Elliott T, Townsend A. A quantitative assay of peptide-dependent class I assembly. European Journal of Immunology. 21: 2025-2031. PMID 1909640 DOI: 10.1002/Eji.1830210909  0.429
1991 Cerundolo V, Elliott T, Elvin J, Bastin J, Rammensee HG, Townsend A. The binding affinity and dissociation rates of peptides for class I major histocompatibility complex molecules. European Journal of Immunology. 21: 2069-75. PMID 1889458 DOI: 10.1002/Eji.1830210915  0.456
1991 Powis SJ, Townsend AR, Deverson EV, Bastin J, Butcher GW, Howard JC. Restoration of antigen presentation to the mutant cell line RMA-S by an MHC-linked transporter. Nature. 354: 528-31. PMID 1758495 DOI: 10.1038/354528A0  0.486
1991 Cerundolo V, Tse AG, Salter RD, Parham P, Townsend A. CD8 independence and specificity of cytotoxic T lymphocytes restricted by HLA-Aw68.1. Proceedings. Biological Sciences / the Royal Society. 244: 169-77. PMID 1715994 DOI: 10.1098/Rspb.1991.0066  0.446
1990 Cerundolo V, Alexander J, Anderson K, Lamb C, Cresswell P, McMichael A, Gotch F, Townsend A. Presentation of viral antigen controlled by a gene in the major histocompatibility complex. Nature. 345: 449-52. PMID 2342577 DOI: 10.1038/345449A0  0.485
1990 Trowsdale J, Hanson I, Mockridge I, Beck S, Townsend A, Kelly A. Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transporters Nature. 348: 741-744. PMID 2259383 DOI: 10.1038/348741A0  0.461
1990 Ljunggren HG, Stam NJ, Ohlén C, Neefjes JJ, Höglund P, Heemels MT, Bastin J, Schumacher TN, Townsend A, Kärre K. Empty MHC class I molecules come out in the cold. Nature. 346: 476-80. PMID 2198471 DOI: 10.1038/346476A0  0.484
1990 Townsend A, Elliott T, Cerundolo V, Foster L, Barber B, Tse A. Assembly of MHC class I molecules analyzed in vitro. Cell. 62: 285-295. PMID 2196996 DOI: 10.1016/0092-8674(90)90366-M  0.444
1990 Elliott T, Townsend A, Cerundolo V. Naturally processed peptides Nature. 348: 195-197. PMID 2172837 DOI: 10.1038/348195A0  0.353
1990 Huet S, Nixon DF, Rothbard JB, Townsend A, Ellis SA, McMichael AJ. Structural homologies between two HLA B27-restricted peptides suggest residues important for interaction with HLA B27. International Immunology. 2: 311-6. PMID 2126195 DOI: 10.1093/Intimm/2.4.311  0.438
1989 Townsend A, Ohlén C, Bastin J, Ljunggren HG, Foster L, Kärre K. Association of class I major histocompatibility heavy and light chains induced by viral peptides. Nature. 340: 443-8. PMID 2666863 DOI: 10.1038/340443A0  0.474
1989 Townsend A, Ohlën C, Foster L, Bastin J, Ljunggren HG, Kärre K. A mutant cell in which association of class I heavy and light chains is induced by viral peptides. Cold Spring Harbor Symposia On Quantitative Biology. 54: 299-308. PMID 2484163 DOI: 10.1101/Sqb.1989.054.01.038  0.462
1989 Gould K, Cossins J, Bastin J, Brownlee GG, Townsend A. A 15 amino acid fragment of influenza nucleoprotein synthesized in the cytoplasm is presented to class I-restricted cytotoxic T lymphocytes. The Journal of Experimental Medicine. 170: 1051-6. PMID 2475569 DOI: 10.1084/Jem.170.3.1051  0.501
1989 Townsend A, Bastin J, Bodmer H, Brownlee G, Davey J, Gotch F, Gould K, Jones I, McMichael A, Rothbard J. Recognition of influenza virus proteins by cytotoxic T lymphocytes. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 323: 527-33. PMID 2474170 DOI: 10.1098/Rstb.1989.0032  0.53
1988 Nixon DF, Townsend AR, Elvin JG, Rizza CR, Gallwey J, McMichael AJ. HIV-1 gag-specific cytotoxic T lymphocytes defined with recombinant vaccinia virus and synthetic peptides. Nature. 336: 484-7. PMID 2461519 DOI: 10.1038/336484A0  0.42
1988 Townsend A, Bastin J, Gould K, Brownlee G, Andrew M, Coupar B, Boyle D, Chan S, Smith G. Defective presentation to class I-restricted cytotoxic T lymphocytes in vaccinia-infected cells is overcome by enhanced degradation of antigen. The Journal of Experimental Medicine. 168: 1211-24. PMID 2459295 DOI: 10.1084/Jem.168.4.1211  0.423
1988 Gould K, Reay P, Townsend A, Brownlee GG. Studies on the nature and mechanism of influenza antigen recognition by murine cytotoxic T cells Virus Research. 11: 65. DOI: 10.1016/0168-1702(88)90219-5  0.435
1987 Rothbard JB, Townsend A, Edwards M, Taylor W. Pattern Recognition Among T-Cell Epitopes Haematology and Blood Transfusion. 31: 324-331. PMID 2450818 DOI: 10.1007/978-3-642-72624-8_68  0.43
1987 Gould KG, Scotney H, Townsend AR, Bastin J, Brownlee GG. Mouse H-2k-restricted cytotoxic T cells recognize antigenic determinants in both the HA1 and HA2 subunits of the influenza A/PR/8/34 hemagglutinin. The Journal of Experimental Medicine. 166: 693-701. PMID 2442286 DOI: 10.1084/Jem.166.3.693  0.394
1987 Bastin J, Rothbard J, Davey J, Jones I, Townsend A. Use of synthetic peptides of influenza nucleoprotein to define epitopes recognized by class I-restricted cytotoxic T lymphocytes. Journal of Experimental Medicine. 165: 1508-1523. PMID 2438367 DOI: 10.1084/Jem.165.6.1508  0.514
1987 Gotch F, Rothbard J, Howland K, Townsend A, McMichael A. Cytotoxic T lymphocytes recognize a fragment of influenza virus matrix protein in association with HLA-A2. Nature. 326: 881-2. PMID 2437457 DOI: 10.1038/326881A0  0.488
1986 Townsend AR, Bastin J, Gould K, Brownlee GG. Cytotoxic T lymphocytes recognize influenza haemagglutinin that lacks a signal sequence. Nature. 324: 575-7. PMID 3491325 DOI: 10.1038/324575A0  0.462
1986 Pala P, Townsend AR, Askonas BA. Viral recognition by influenza A virus cross-reactive cytotoxic T (Tc) cells: the proportion of Tc cells that recognize nucleoprotein varies between individual mice. European Journal of Immunology. 16: 193-8. PMID 3485529 DOI: 10.1002/Eji.1830160215  0.392
1986 Townsend AR, Rothbard J, Gotch FM, Bahadur G, Wraith D, McMichael AJ. The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides. Cell. 44: 959-68. PMID 2420472 DOI: 10.1016/0092-8674(86)90019-X  0.526
1985 Townsend A. Molecules at work on the T-cell surface Immunology Today. 6: 68-70. PMID 25291529 DOI: 10.1016/0167-5699(85)90015-5  0.374
1985 Townsend AR, Gotch FM, Davey J. Cytotoxic T cells recognize fragments of the influenza nucleoprotein. Cell. 42: 457-67. PMID 2411422 DOI: 10.1016/0092-8674(85)90103-5  0.453
1985 Gould K, Kingsbury D, Brownlee G, Townsend A, Gotch F, McMichael A. Construction of chimaeric haemagglutinin genes in order to investigate determinants for recognition by murine cytotoxic T cells Virus Research. 3: 55. DOI: 10.1016/0168-1702(85)90361-2  0.338
1984 Townsend AR, McMichael AJ, Carter NP, Huddleston JA, Brownlee GG. Cytotoxic T cell recognition of the influenza nucleoprotein and hemagglutinin expressed in transfected mouse L cells. Cell. 39: 13-25. PMID 6091906 DOI: 10.1016/0092-8674(84)90187-9  0.405
1983 Weiss EH, Mellor AL, Golden L, Bud H, Hurst J, Flavell RA, Simpson E, James R, Townsend AR, Festenstein H. Structure and expression of class I genes of the mouse major histocompatibility complex. Haematology and Blood Transfusion. 28: 454-8. PMID 6862309 DOI: 10.1007/978-3-642-68761-7_87  0.435
1983 Townsend AR, Taylor PM, Mellor AL, Askonas BA. Recognition of Db and Kb gene products by influenza-specific cytotoxic T cells. Immunogenetics. 17: 283-94. PMID 6601053 DOI: 10.1007/Bf00364412  0.403
1982 Mellor AL, Golden L, Weiss E, Bullman H, Hurst J, Simpson E, James RF, Townsend AR, Taylor PM, Schmidt W, Ferluga J, Leben L, Santamaria M, Atfield G, Festenstein H, et al. Expression of murine H-2Kb histocompatibility antigen in cells transformed with cloned H-2 genes. Nature. 298: 529-34. PMID 6285197 DOI: 10.1038/298529A0  0.396
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