| Year |
Citation |
Score |
| 2023 |
Mahanti M, Pal KB, Kumar R, Schulze M, Leffler H, Logan DT, Nilsson UJ. Ligand Sulfur Oxidation State Progressively Alters Galectin-3-Ligand Complex Conformations To Induce Affinity-Influencing Hydrogen Bonds. Journal of Medicinal Chemistry. 66: 14716-14723. PMID 37878264 DOI: 10.1021/acs.jmedchem.3c01223 |
0.738 |
|
| 2021 |
Hassan M, Baussière F, Guzelj S, Sundin AP, Håkansson M, Kovačič R, Leffler H, Tomašič T, Anderluh M, Jakopin Ž, Nilsson UJ. Structure-Guided Design of d-Galactal Derivatives with High Affinity and Selectivity for the Galectin-8 N-Terminal Domain. Acs Medicinal Chemistry Letters. 12: 1745-1752. PMID 34795863 DOI: 10.1021/acsmedchemlett.1c00371 |
0.323 |
|
| 2021 |
Hassan M, van Klaveren S, Håkansson M, Diehl C, Kovačič R, Baussière F, Sundin AP, Dernovšek J, Walse B, Zetterberg F, Leffler H, Anderluh M, Tomašič T, Jakopin Ž, Nilsson UJ. Benzimidazole-galactosides bind selectively to the Galectin-8 N-Terminal domain: Structure-based design and optimisation. European Journal of Medicinal Chemistry. 223: 113664. PMID 34225180 DOI: 10.1016/j.ejmech.2021.113664 |
0.302 |
|
| 2020 |
Wu C, Yong C, Zhong Q, Wang Z, Nilsson UJ, Zhang Y. Synthesis of tricyclic carbohydrate-benzene hybrids as selective inhibitors of galectin-1 and galectin-8 N-terminal domains. Rsc Advances. 10: 19636-19642. PMID 35515421 DOI: 10.1039/d0ra03144e |
0.338 |
|
| 2020 |
Madar Johansson M, Bélurier E, Papageorgiou AC, Sundin AP, Rahkila J, Kallonen T, Nilsson UJ, Maatsola S, Nyholm TKM, Käpylä J, Corander J, Leino R, Finne J, Teneberg S, Haataja S. The binding mechanism of the virulence factor adhesin P subtype to globotetraosylceramide is associated with systemic disease. The Journal of Biological Chemistry. PMID 32796033 DOI: 10.1074/Jbc.Ra120.014818 |
0.306 |
|
| 2020 |
Mahanti M, Pal KB, Sundin AP, Leffler H, Nilsson UJ. Epimers Switch Galectin-9 Domain Selectivity: 3-Aryl Galactosides Bind the C-Terminal and Gulosides Bind the N-Terminal. Acs Medicinal Chemistry Letters. 11: 34-39. PMID 31938460 DOI: 10.1021/Acsmedchemlett.9B00396 |
0.771 |
|
| 2020 |
Wu C, Yong C, Zhong Q, Wang Z, Nilsson UJ, Zhang Y. Synthesis of tricyclic carbohydrate–benzene hybrids as selective inhibitors of galectin-1 and galectin-8 N-terminal domains Rsc Advances. 10: 19636-19642. DOI: 10.1039/D0Ra03144E |
0.365 |
|
| 2019 |
Dahlqvist A, Mandal S, Peterson K, Håkansson M, Logan DT, Zetterberg FR, Leffler H, Nilsson UJ. 3-Substituted 1-Naphthamidomethyl-C-galactosyls Interact with Two Unique Sub-sites for High-Affinity and High-Selectivity Inhibition of Galectin-3. Molecules (Basel, Switzerland). 24. PMID 31842451 DOI: 10.3390/Molecules24244554 |
0.404 |
|
| 2019 |
Pal KB, Mahanti M, Leffler H, Nilsson UJ. A Galactoside-Binding Protein Tricked into Binding Unnatural Pyranose Derivatives: 3-Deoxy-3-Methyl-Gulosides Selectively Inhibit Galectin-1. International Journal of Molecular Sciences. 20. PMID 31382488 DOI: 10.3390/Ijms20153786 |
0.766 |
|
| 2019 |
Dahlqvist A, Zetterberg FR, Leffler H, Nilsson UJ. Aminopyrimidine-galactose hybrids are highly selective galectin-3 inhibitors. Medchemcomm. 10: 913-925. PMID 31303989 DOI: 10.1039/C9Md00183B |
0.395 |
|
| 2019 |
Kumar R, Ignjatović MM, Peterson K, Olsson M, Leffler H, Ryde U, Nilsson UJ, Logan DT. Structure and energetics of ligand-fluorine interactions with galectin-3 backbone and side-chain amides - insight into solvation effects and multipolar interactions. Chemmedchem. PMID 31246331 DOI: 10.2210/Pdb6Qlo/Pdb |
0.348 |
|
| 2019 |
Dahlqvist A, Furevi A, Warlin N, Leffler H, Nilsson UJ. Stereo- and regioselective hydroboration of 1--methylene pyranoses: discovery of aryltriazolylmethyl C-galactopyranosides as selective galectin-1 inhibitors. Beilstein Journal of Organic Chemistry. 15: 1046-1060. PMID 31164942 DOI: 10.3762/Bjoc.15.102 |
0.395 |
|
| 2019 |
Stegmayr J, Zetterberg F, Carlsson MC, Huang X, Sharma G, Kahl-Knutson B, Schambye H, Nilsson UJ, Oredsson S, Leffler H. Extracellular and intracellular small-molecule galectin-3 inhibitors. Scientific Reports. 9: 2186. PMID 30778105 DOI: 10.1038/S41598-019-38497-8 |
0.352 |
|
| 2019 |
Kumar R, Peterson K, Misini Ignjatović M, Leffler H, Ryde U, Nilsson UJ, Logan DT. Substituted polyfluoroaryl interactions with an arginine side chain in galectin-3 are governed by steric-, desolvation and electronic conjugation effects. Organic & Biomolecular Chemistry. PMID 30632578 DOI: 10.2210/Pdb6I76/Pdb |
0.424 |
|
| 2019 |
Verteramo ML, Stenström O, Misini Ignjatovic M, Caldararu O, Olsson MA, Manzoni F, Leffler H, Oksanen E, Logan DT, Nilsson UJ, Ryde U, Akke M. Interplay between Conformational Entropy and Solvation Entropy in Protein-Ligand Binding. Journal of the American Chemical Society. PMID 30618244 DOI: 10.1021/Jacs.8B11099 |
0.323 |
|
| 2018 |
Ingemann Nielsen M, Stegmayr J, Grant OC, Yang Z, Nilsson UJ, Boos I, Carlsson MC, Woods RJ, Unverzagt C, Leffler H, Wandall HH. Galectin binding to cells and glycoproteins with genetically modified glycosylation reveals galectin-glycan specificities in a natural context. The Journal of Biological Chemistry. PMID 30385505 DOI: 10.1074/Jbc.Ra118.004636 |
0.419 |
|
| 2018 |
Pal KB, Mahanti M, Huang X, Persson S, Sundin AP, Zetterberg FR, Oredsson S, Leffler H, Nilsson UJ. Quinoline-galactose hybrids bind selectively with high affinity to a galectin-8 N-terminal domain. Organic & Biomolecular Chemistry. PMID 30117507 DOI: 10.1039/C8Ob01354C |
0.78 |
|
| 2018 |
Wahlgren WY, Dunevall E, North RA, Paz A, Scalise M, Bisignano P, Bengtsson-Palme J, Goyal P, Claesson E, Caing-Carlsson R, Andersson R, Beis K, Nilsson UJ, Farewell A, Pochini L, et al. Substrate-bound outward-open structure of a Na-coupled sialic acid symporter reveals a new Na site. Nature Communications. 9: 1753. PMID 29717135 DOI: 10.1038/S41467-018-04045-7 |
0.312 |
|
| 2018 |
Pal KB, Mahanti M, Nilsson UJ. Arynes in the Monoarylation of Unprotected Carbohydrate Amines. Organic Letters. PMID 29359567 DOI: 10.1021/Acs.Orglett.7B03741 |
0.743 |
|
| 2018 |
Sundqvist M, Welin A, Elmwall J, Osla V, Nilsson UJ, Leffler H, Bylund J, Karlsson A. Galectin-3 type-C self-association on neutrophil surfaces; The carbohydrate recognition domain regulates cell function. Journal of Leukocyte Biology. PMID 29345346 DOI: 10.1002/Jlb.3A0317-110R |
0.367 |
|
| 2018 |
Kumar R, Peterson K, Nilsson U, Logan D. Galectin-3: studying role of fluorine interaction to achieve high affinity and selectivity Acta Crystallographica Section a Foundations and Advances. 74: e198-e198. DOI: 10.1107/S2053273318092197 |
0.32 |
|
| 2018 |
Peterson K, Collins PM, Huang X, Kahl-Knutsson B, Essén S, Zetterberg FR, Oredsson S, Leffler H, Blanchard H, Nilsson UJ. Aromatic heterocycle galectin-1 interactions for selective single-digit nM affinity ligands Rsc Advances. 8: 24913-24922. DOI: 10.1039/C8Ra04389B |
0.368 |
|
| 2017 |
Noresson AL, Aurelius O, Öberg CT, Engström O, Sundin AP, Håkansson M, Stenström O, Akke M, Logan DT, Leffler H, Nilsson UJ. Designing interactions by control of protein-ligand complex conformation: tuning arginine-arene interaction geometry for enhanced electrostatic protein-ligand interactions. Chemical Science. 9: 1014-1021. PMID 29675148 DOI: 10.1039/C7Sc04749E |
0.345 |
|
| 2017 |
Peterson K, Kumar R, Stenström O, Verma P, Verma PR, Håkansson M, Kahl-Knutsson B, Zetterberg F, Leffler H, Akke M, Logan DT, Nilsson UJ. Systematic tuning of fluoro-galectin-3 interactions provides thiodigalactoside derivatives with single digit nM affinity and high selectivity. Journal of Medicinal Chemistry. PMID 29284090 DOI: 10.1021/Acs.Jmedchem.7B01626 |
0.386 |
|
| 2017 |
Zetterberg FR, Peterson K, Johnsson R, Brimert T, Håkansson M, Logan DT, Leffler H, Nilsson UJ. Monosaccharide derivatives with low nM lectin affinity and high selectivity based on combined fluorine-amide, phenyl-arginine, sulfur-π, and halogen bond interactions. Chemmedchem. PMID 29194992 DOI: 10.1002/Cmdc.201700744 |
0.4 |
|
| 2017 |
Haataja S, Verma P, Fu O, Papageorgiou A, Pöysti S, Pieters R, Nilsson U, Finne J. Rationally designed chemically modified glycodendrimer ligand analogues inhibit Streptococcus suis adhesin SadP in picomolar concentrations. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 29094420 DOI: 10.1002/Chem.201704493 |
0.337 |
|
| 2017 |
Magescas J, Sengmanivong L, Viau A, Mayeux A, Dang T, Burtin M, Nilsson UJ, Leffler H, Poirier F, Terzi F, Delacour D. Spindle pole cohesion requires glycosylation-mediated localization of NuMA. Scientific Reports. 7: 1474. PMID 28469279 DOI: 10.1038/S41598-017-01614-6 |
0.323 |
|
| 2016 |
Tolnai GL, Nilsson UJ, Olofsson B. Efficient O-Functionalization of Carbohydrates with Electrophilic Reagents. Angewandte Chemie (International Ed. in English). 55: 11226-30. PMID 27528184 DOI: 10.1002/Anie.201605999 |
0.605 |
|
| 2016 |
Rajput VK, MacKinnon A, Mandal S, Collins P, Blanchard H, Leffler H, Sethi T, Schambye H, Mukhopadhyay B, Nilsson UJ. A selective galactose-coumarin-derived galectin-3 inhibitor demonstrates involvement of galectin-3-glycan interactions in a pulmonary fibrosis model. Journal of Medicinal Chemistry. PMID 27500311 DOI: 10.1021/Acs.Jmedchem.6B00957 |
0.717 |
|
| 2016 |
Delaine T, Collins P, Mac Kinnon A, Sharma G, Stegmayr J, Rajput VK, Mandal S, Cumpstey I, Larumbe A, Salameh BA, Kahl-Knutsson B, Van Hattum H, Van Scherpenzeel M, Pieters RJ, Sethi T, ... ... Nilsson U, et al. Galectin-3-binding glycomimetics that strongly reduce bleomycin-induced lung fibrosis and modulate intracellular glycan recognition. Chembiochem : a European Journal of Chemical Biology. PMID 27356186 DOI: 10.1002/Cbic.201600285 |
0.398 |
|
| 2016 |
Stegmayr J, Lepur A, Kahl-Knutson B, Aguilar-Moncayo M, Klyosov AA, Field RA, Oredsson S, Nilsson UJ, Leffler H. Low or no inhibitory potency of the canonical galectin carbohydrate binding site by pectins and galactomannans. The Journal of Biological Chemistry. PMID 27129206 DOI: 10.1074/Jbc.M116.721464 |
0.643 |
|
| 2016 |
Bum-Erdene K, Leffler H, Nilsson UJ, Blanchard H. Structural characterisation of human galectin-4 N-terminal carbohydrate recognition domain in complex with glycerol, lactose, 3'-sulfo-lactose, and 2'-fucosyllactose. Scientific Reports. 6: 20289. PMID 26828567 DOI: 10.1038/Srep20289 |
0.415 |
|
| 2016 |
Mandal S, Rajput VK, Sundin AP, Leffler H, Mukhopadhyay B, Nilsson UJ. Galactose-amidine derivatives as selective antagonists of galectin-9 Canadian Journal of Chemistry. 94: 936-939. DOI: 10.1139/Cjc-2015-0598 |
0.735 |
|
| 2015 |
Bum-Erdene K, Leffler H, Nilsson UJ, Blanchard H. Structural characterization of human galectin-4 C-terminal domain: elucidating the molecular basis for recognition of glycosphingolipids, sulfated saccharides and blood group antigens. The Febs Journal. PMID 26077389 DOI: 10.1111/Febs.13348 |
0.405 |
|
| 2015 |
Mandal S, Nilsson UJ. Tri-isopropylsilyl thioglycosides as masked glycosyl thiol nucleophiles for the synthesis of S-linked glycosides and glyco-conjugates. Organic & Biomolecular Chemistry. 12: 4816-9. PMID 24867410 DOI: 10.1039/C4Ob00741G |
0.336 |
|
| 2015 |
Peterson K, Weymouth-Wilson A, Nilsson UJ. Aryl Sulfonates in Inversions at Secondary Carbohydrate Hydroxyl Groups: A New and Improved Route Toward 3-azido-3-deoxy-β-d-galactopyranosides Journal of Carbohydrate Chemistry. 34: 490-499. DOI: 10.1080/07328303.2015.1105248 |
0.308 |
|
| 2015 |
Mackinnon A, Chen WS, Leffler H, Panjwani N, Schambye H, Sethi T, Nilsson UJ. Design, synthesis, And applications of galectin modulators in human health Topics in Medicinal Chemistry. 12: 95-122. DOI: 10.1007/7355_2014_49 |
0.375 |
|
| 2014 |
Rajput VK, Leffler H, Nilsson UJ, Mukhopadhyay B. Synthesis and evaluation of iminocoumaryl and coumaryl derivatized glycosides as galectin antagonists. Bioorganic & Medicinal Chemistry Letters. 24: 3516-20. PMID 24973029 DOI: 10.1016/J.Bmcl.2014.05.063 |
0.739 |
|
| 2014 |
von Mach T, Carlsson MC, Straube T, Nilsson U, Leffler H, Jacob R. Ligand binding and complex formation of galectin-3 is modulated by pH variations. The Biochemical Journal. 457: 107-15. PMID 24147723 DOI: 10.1042/Bj20130933 |
0.328 |
|
| 2014 |
Mackeviča J, Ostrovskis P, Leffler H, Nilsson UJ, Rudovica V, Viksna A, Belyakov S, Turks M. Synthesis of 1,2,3-triazole-linked galactohybrids and their inhibitory activities on galectins Arkivoc. 2014: 90-112. DOI: 10.3998/Ark.5550190.P008.402 |
0.37 |
|
| 2013 |
Kouki A, Pieters RJ, Nilsson UJ, Loimaranta V, Finne J, Haataja S. Bacterial Adhesion of Streptococcus suis to Host Cells and Its Inhibition by Carbohydrate Ligands. Biology. 2: 918-35. PMID 24833053 DOI: 10.3390/Biology2030918 |
0.366 |
|
| 2013 |
Bum-Erdene K, Gagarinov IA, Collins PM, Winger M, Pearson AG, Wilson JC, Leffler H, Nilsson UJ, Grice ID, Blanchard H. Investigation into the feasibility of thioditaloside as a novel scaffold for galectin-3-specific inhibitors. Chembiochem : a European Journal of Chemical Biology. 14: 1331-42. PMID 23864426 DOI: 10.1002/Cbic.201300245 |
0.398 |
|
| 2013 |
van Hattum H, Branderhorst HM, Moret EE, Nilsson UJ, Leffler H, Pieters RJ. Tuning the preference of thiodigalactoside- and lactosamine-based ligands to galectin-3 over galectin-1. Journal of Medicinal Chemistry. 56: 1350-4. PMID 23281927 DOI: 10.1021/Jm301677R |
0.37 |
|
| 2012 |
Lepur A, Salomonsson E, Nilsson UJ, Leffler H. Ligand induced galectin-3 protein self-association. The Journal of Biological Chemistry. 287: 21751-6. PMID 22549776 DOI: 10.1074/Jbc.C112.358002 |
0.362 |
|
| 2012 |
Collins PM, Oberg CT, Leffler H, Nilsson UJ, Blanchard H. Taloside inhibitors of galectin-1 and galectin-3. Chemical Biology & Drug Design. 79: 339-46. PMID 22136701 DOI: 10.1111/J.1747-0285.2011.01283.X |
0.342 |
|
| 2012 |
Saraboji K, HÃ¥kansson M, Genheden S, Diehl C, Qvist J, Weininger U, Nilsson UJ, Leffler H, Ryde U, Akke M, Logan DT. The carbohydrate-binding site in galectin-3 is preorganized to recognize a sugarlike framework of oxygens: ultra-high-resolution structures and water dynamics. Biochemistry. 51: 296-306. PMID 22111949 DOI: 10.1021/Bi201459P |
0.333 |
|
| 2012 |
Masuyer G, Jabeen T, Öberg CT, Leffler H, Nilsson UJ, Acharya KR. Inhibition mechanism of human galectin-7 by a novel galactose-benzylphosphate inhibitor. The Febs Journal. 279: 193-202. PMID 22059385 DOI: 10.1111/J.1742-4658.2011.08414.X |
0.388 |
|
| 2011 |
Kouki A, Haataja S, Loimaranta V, Pulliainen AT, Nilsson UJ, Finne J. Identification of a novel streptococcal adhesin P (SadP) protein recognizing galactosyl-α1-4-galactose-containing glycoconjugates: convergent evolution of bacterial pathogens to binding of the same host receptor. The Journal of Biological Chemistry. 286: 38854-64. PMID 21908601 DOI: 10.1074/Jbc.M111.260992 |
0.337 |
|
| 2011 |
Öberg CT, Noresson AL, Leffler H, Nilsson UJ. Arene-anion based arginine-binding motif on a galactose scaffold: structure-activity relationships of interactions with arginine-rich galectins. Chemistry (Weinheim An Der Bergstrasse, Germany). 17: 8139-44. PMID 21656580 DOI: 10.1002/Chem.201003247 |
0.391 |
|
| 2011 |
Oberg CT, Leffler H, Nilsson UJ. Inhibition of galectins with small molecules. Chimia. 65: 18-23. PMID 21469439 DOI: 10.2533/Chimia.2011.18 |
0.393 |
|
| 2011 |
Salomonsson E, Thijssen VL, Griffioen AW, Nilsson UJ, Leffler H. The anti-angiogenic peptide anginex greatly enhances galectin-1 binding affinity for glycoproteins. The Journal of Biological Chemistry. 286: 13801-4. PMID 21372130 DOI: 10.1074/Jbc.C111.229096 |
0.359 |
|
| 2011 |
Harrison JA, Kartha KP, Fournier EJ, Lowary TL, Malet C, Nilsson UJ, Hindsgaul O, Schenkman S, Naismith JH, Field RA. Probing the acceptor substrate binding site of Trypanosoma cruzi trans-sialidase with systematically modified substrates and glycoside libraries. Organic & Biomolecular Chemistry. 9: 1653-60. PMID 21253654 DOI: 10.1039/C0Ob00826E |
0.749 |
|
| 2011 |
Fritzson I, Bedingfield PTP, Sundin AP, McConkey G, Nilsson UJ. N-Substituted salicylamides as selective malaria parasite dihydroorotate dehydrogenase inhibitors Medchemcomm. 2: 895. DOI: 10.1039/C1Md00118C |
0.355 |
|
| 2011 |
Öberg CT, Noresson AL, Leffler H, Nilsson UJ. Synthesis of 3-amido-3-deoxy-β-d-talopyranosides: All-cis-substituted pyranosides as lectin inhibitors Tetrahedron. 67: 9164-9172. DOI: 10.1016/J.Tet.2011.09.098 |
0.389 |
|
| 2010 |
Diehl C, Engström O, Delaine T, Håkansson M, Genheden S, Modig K, Leffler H, Ryde U, Nilsson UJ, Akke M. Protein flexibility and conformational entropy in ligand design targeting the carbohydrate recognition domain of galectin-3. Journal of the American Chemical Society. 132: 14577-89. PMID 20873837 DOI: 10.1021/Ja105852Y |
0.371 |
|
| 2010 |
Salomonsson E, Larumbe A, Tejler J, Tullberg E, Rydberg H, Sundin A, Khabut A, Frejd T, Lobsanov YD, Rini JM, Nilsson UJ, Leffler H. Monovalent interactions of galectin-1. Biochemistry. 49: 9518-32. PMID 20873803 DOI: 10.1021/Bi1009584 |
0.372 |
|
| 2010 |
Salomonsson E, Carlsson MC, Osla V, Hendus-Altenburger R, Kahl-Knutson B, Oberg CT, Sundin A, Nilsson R, Nordberg-Karlsson E, Nilsson UJ, Karlsson A, Rini JM, Leffler H. Mutational tuning of galectin-3 specificity and biological function. The Journal of Biological Chemistry. 285: 35079-91. PMID 20807768 DOI: 10.1074/Jbc.M109.098160 |
0.367 |
|
| 2010 |
Gouin SG, García Fernández JM, Vanquelef E, Dupradeau FY, Salomonsson E, Leffler H, Ortega-Muñoz M, Nilsson UJ, Kovensky J. Multimeric lactoside "click clusters" as tools to investigate the effect of linker length in specific interactions with peanut lectin, galectin-1, and -3. Chembiochem : a European Journal of Chemical Biology. 11: 1430-42. PMID 20549756 DOI: 10.1002/Cbic.201000167 |
0.366 |
|
| 2010 |
Salameh BA, Cumpstey I, Sundin A, Leffler H, Nilsson UJ. 1H-1,2,3-triazol-1-yl thiodigalactoside derivatives as high affinity galectin-3 inhibitors. Bioorganic & Medicinal Chemistry. 18: 5367-78. PMID 20538469 DOI: 10.1016/J.Bmc.2010.05.040 |
0.414 |
|
| 2010 |
Fritzson I, Svensson B, Al-Karadaghi S, Walse B, Wellmar U, Nilsson UJ, da Graça Thrige D, Jönsson S. Inhibition of human DHODH by 4-hydroxycoumarins, fenamic acids, and N-(alkylcarbonyl)anthranilic acids identified by structure-guided fragment selection. Chemmedchem. 5: 608-17. PMID 20183850 DOI: 10.1002/Cmdc.200900454 |
0.359 |
|
| 2009 |
Tejler J, Salameh B, Leffler H, Nilsson UJ. Fragment-based development of triazole-substituted O-galactosyl aldoximes with fragment-induced affinity and selectivity for galectin-3. Organic & Biomolecular Chemistry. 7: 3982-90. PMID 19763301 DOI: 10.1039/B909091F |
0.429 |
|
| 2009 |
Oberg CT, Noresson AL, Delaine T, Larumbe A, Tejler J, von Wachenfeldt H, Nilsson UJ. Synthesis of 3-azido-3-deoxy-beta-D-galactopyranosides. Carbohydrate Research. 344: 1282-4. PMID 19505681 DOI: 10.1016/J.Carres.2009.05.005 |
0.308 |
|
| 2009 |
van Scherpenzeel M, Moret EE, Ballell L, Liskamp RM, Nilsson UJ, Leffler H, Pieters RJ. Synthesis and evaluation of new thiodigalactoside-based chemical probes to label galectin-3. Chembiochem : a European Journal of Chemical Biology. 10: 1724-33. PMID 19492387 DOI: 10.1002/Cbic.200900198 |
0.353 |
|
| 2008 |
Delaine T, Cumpstey I, Ingrassia L, Le Mercier M, Okechukwu P, Leffler H, Kiss R, Nilsson UJ. Galectin-inhibitory thiodigalactoside ester derivatives have antimigratory effects in cultured lung and prostate cancer cells. Journal of Medicinal Chemistry. 51: 8109-14. PMID 19053747 DOI: 10.1021/Jm801077J |
0.313 |
|
| 2008 |
Oberg CT, Blanchard H, Leffler H, Nilsson UJ. Protein subtype-targeting through ligand epimerization: talose-selectivity of galectin-4 and galectin-8. Bioorganic & Medicinal Chemistry Letters. 18: 3691-4. PMID 18539029 DOI: 10.1016/J.Bmcl.2008.05.066 |
0.427 |
|
| 2008 |
Cumpstey I, Salomonsson E, Sundin A, Leffler H, Nilsson UJ. Double affinity amplification of galectin-ligand interactions through arginine-arene interactions: synthetic, thermodynamic, and computational studies with aromatic diamido thiodigalactosides. Chemistry (Weinheim An Der Bergstrasse, Germany). 14: 4233-45. PMID 18366047 DOI: 10.1002/Chem.200701932 |
0.404 |
|
| 2008 |
Oberg CT, Leffler H, Nilsson UJ. Arginine binding motifs: design and synthesis of galactose-derived arginine tweezers as galectin-3 inhibitors. Journal of Medicinal Chemistry. 51: 2297-301. PMID 18318467 DOI: 10.1021/Jm701266Y |
0.396 |
|
| 2008 |
Cederfur C, Salomonsson E, Nilsson J, Halim A, Oberg CT, Larson G, Nilsson UJ, Leffler H. Different affinity of galectins for human serum glycoproteins: galectin-3 binds many protease inhibitors and acute phase proteins. Glycobiology. 18: 384-94. PMID 18263896 DOI: 10.1093/Glycob/Cwn015 |
0.343 |
|
| 2007 |
Cumpstey I, Salomonsson E, Sundin A, Leffler H, Nilsson UJ. Studies of arginine-arene interactions through synthesis and evaluation of a series of galectin-binding aromatic lactose esters. Chembiochem : a European Journal of Chemical Biology. 8: 1389-98. PMID 17631664 DOI: 10.1002/Cbic.200700040 |
0.436 |
|
| 2007 |
Tejler J, Skogman F, Leffler H, Nilsson UJ. Synthesis of galactose-mimicking 1H-(1,2,3-triazol-1-yl)-mannosides as selective galectin-3 and 9N inhibitors. Carbohydrate Research. 342: 1869-75. PMID 17407769 DOI: 10.1016/J.Carres.2007.03.012 |
0.399 |
|
| 2007 |
Carlsson S, Oberg CT, Carlsson MC, Sundin A, Nilsson UJ, Smith D, Cummings RD, Almkvist J, Karlsson A, Leffler H. Affinity of galectin-8 and its carbohydrate recognition domains for ligands in solution and at the cell surface. Glycobiology. 17: 663-76. PMID 17339281 DOI: 10.1093/Glycob/Cwm026 |
0.399 |
|
| 2006 |
Tejler J, Tullberg E, Frejd T, Leffler H, Nilsson UJ. Synthesis of multivalent lactose derivatives by 1,3-dipolar cycloadditions: selective galectin-1 inhibition. Carbohydrate Research. 341: 1353-62. PMID 16697988 DOI: 10.1016/J.Carres.2006.04.028 |
0.414 |
|
| 2006 |
Aplander K, Tejler J, Toftered J, Carlsson S, Kahl-Knutsson B, Sundin A, Leffler H, Nilsson UJ. Synthesis of a 3'-naphthamido-LacNAc fluorescein conjugate with high selectivity and affinity for galectin-3. Carbohydrate Research. 341: 1363-9. PMID 16697983 DOI: 10.1016/J.Carres.2006.04.027 |
0.354 |
|
| 2006 |
Salameh BA, Sundin A, Leffler H, Nilsson UJ. Thioureido N-acetyllactosamine derivatives as potent galectin-7 and 9N inhibitors. Bioorganic & Medicinal Chemistry. 14: 1215-20. PMID 16242339 DOI: 10.1016/J.Bmc.2005.09.050 |
0.379 |
|
| 2006 |
Bergh A, Leffler H, Sundin A, Nilsson UJ, Kann N. Cobalt-mediated solid phase synthesis of 3-O-alkynylbenzyl galactosides and their evaluation as galectin inhibitors Tetrahedron. 62: 8309-8317. DOI: 10.1016/J.Tet.2006.06.057 |
0.388 |
|
| 2005 |
Cumpstey I, Sundin A, Leffler H, Nilsson UJ. C2-symmetrical thiodigalactoside bis-benzamido derivatives as high-affinity inhibitors of galectin-3: efficient lectin inhibition through double arginine-arene interactions. Angewandte Chemie (International Ed. in English). 44: 5110-2. PMID 16007713 DOI: 10.1002/Anie.200500627 |
0.376 |
|
| 2005 |
Salameh BA, Leffler H, Nilsson UJ. 3-(1,2,3-Triazol-1-yl)-1-thio-galactosides as small, efficient, and hydrolytically stable inhibitors of galectin-3. Bioorganic & Medicinal Chemistry Letters. 15: 3344-6. PMID 15963723 DOI: 10.1016/J.Bmcl.2005.05.084 |
0.395 |
|
| 2005 |
Billing JF, Nilsson UJ. C2-symmetric macrocyclic carbohydrate/amino acid hybrids through copper(I)-catalyzed formation of 1,2,3-triazoles. The Journal of Organic Chemistry. 70: 4847-50. PMID 15932327 DOI: 10.1021/Jo050585L |
0.396 |
|
| 2005 |
Cumpstey I, Carlsson S, Leffler H, Nilsson UJ. Synthesis of a phenyl thio-beta-D-galactopyranoside library from 1,5-difluoro-2,4-dinitrobenzene: discovery of efficient and selective monosaccharide inhibitors of galectin-7. Organic & Biomolecular Chemistry. 3: 1922-32. PMID 15889175 DOI: 10.1039/B502354H |
0.415 |
|
| 2005 |
Tejler J, Leffler H, Nilsson UJ. Synthesis of O-galactosyl aldoximes as potent LacNAc-mimetic galectin-3 inhibitors. Bioorganic & Medicinal Chemistry Letters. 15: 2343-5. PMID 15837322 DOI: 10.1016/J.Bmcl.2005.02.079 |
0.353 |
|
| 2005 |
Ohlsson J, Larsson A, Haataja S, Alajääski J, Stenlund P, Pinkner JS, Hultgren SJ, Finne J, Kihlberg J, Nilsson UJ. Structure-activity relationships of galabioside derivatives as inhibitors of E. coli and S. suis adhesins: nanomolar inhibitors of S. suis adhesins. Organic & Biomolecular Chemistry. 3: 886-900. PMID 15731876 DOI: 10.1039/B416878J |
0.359 |
|
| 2005 |
Sörme P, Arnoux P, Kahl-Knutsson B, Leffler H, Rini JM, Nilsson UJ. Structural and thermodynamic studies on cation-Pi interactions in lectin-ligand complexes: high-affinity galectin-3 inhibitors through fine-tuning of an arginine-arene interaction. Journal of the American Chemical Society. 127: 1737-43. PMID 15701008 DOI: 10.1021/Ja043475P |
0.44 |
|
| 2005 |
Billing JF, Nilsson UJ. Synthesis of a C3-symmetric macrocycle with alternating sugar amino acid and tyrosine residues Tetrahedron Letters. 46: 991-993. DOI: 10.1016/J.Tetlet.2004.12.038 |
0.333 |
|
| 2005 |
Billing JF, Nilsson UJ. Cyclic peptides containing a δ-sugar amino acid—synthesis and evaluation as artificial receptors Tetrahedron. 61: 863-874. DOI: 10.1016/J.Tet.2004.11.024 |
0.343 |
|
| 2004 |
Sörme P, Kahl-Knutsson B, Huflejt M, Nilsson UJ, Leffler H. Fluorescence polarization as an analytical tool to evaluate galectin-ligand interactions. Analytical Biochemistry. 334: 36-47. PMID 15464951 DOI: 10.1016/J.Ab.2004.06.042 |
0.393 |
|
| 2004 |
Aspholm-Hurtig M, Dailide G, Lahmann M, Kalia A, Ilver D, Roche N, Vikström S, Sjöström R, Lindén S, Bäckström A, Lundberg C, Arnqvist A, Mahdavi J, Nilsson UJ, Velapatiño B, et al. Functional adaptation of BabA, the H. pylori ABO blood group antigen binding adhesin. Science (New York, N.Y.). 305: 519-22. PMID 15273394 DOI: 10.1126/Science.1098801 |
0.336 |
|
| 2004 |
Nilsson U, Toftered J. Synthesis of Chiral Macrocycles by Cyclodimerization of Diamines with Stepwise Nucleophilic Aromatic Substitution of 1,5-Difluoro-2,4-dinitrobenzene Synlett. 2004: 2517-2520. DOI: 10.1055/S-2004-835633 |
0.331 |
|
| 2004 |
Grundberg HE, Wendt OF, Nilsson UJ. Synthesis and conformational analysis of 9,10-bis-aminomethyl-11,12- dicarboxy-dibenzobarrelene derivatives Tetrahedron Letters. 45: 6083-6085. DOI: 10.1016/J.Tetlet.2004.04.197 |
0.354 |
|
| 2003 |
Oberg CT, Carlsson S, Fillion E, Leffler H, Nilsson UJ. Efficient and expedient two-step pyranose-retaining fluorescein conjugation of complex reducing oligosaccharides: galectin oligosaccharide specificity studies in a fluorescence polarization assay. Bioconjugate Chemistry. 14: 1289-97. PMID 14624646 DOI: 10.1021/Bc034130J |
0.312 |
|
| 2003 |
Sörme P, Kahl-Knutsson B, Wellmar U, Magnusson BG, Leffler H, Nilsson UJ. Design and synthesis of galectin inhibitors. Methods in Enzymology. 363: 157-69. PMID 14579574 DOI: 10.1016/S0076-6879(03)01050-4 |
0.422 |
|
| 2003 |
Sörme P, Kahl-Knutson B, Wellmar U, Nilsson UJ, Leffler H. Fluorescence polarization to study galectin-ligand interactions. Methods in Enzymology. 362: 504-12. PMID 12968384 DOI: 10.1016/S0076-6879(03)01033-4 |
0.352 |
|
| 2003 |
Larsson A, Ohlsson J, Dodson KW, Hultgren SJ, Nilsson U, Kihlberg J. Quantitative studies of the binding of the class II PapG adhesin from uropathogenic Escherichia coli to oligosaccharides. Bioorganic & Medicinal Chemistry. 11: 2255-61. PMID 12713835 DOI: 10.1016/S0968-0896(03)00114-7 |
0.37 |
|
| 2003 |
Ohlsson J, Sundin A, Nilsson UJ. Conformational studies on phenyl thioglycosides: a remote effect on disaccharide linkage by phenyl aglycons attenuates recognition of galabiosides by a bacterial adhesin. Chemical Communications (Cambridge, England). 384-5. PMID 12613624 DOI: 10.1039/B210649C |
0.326 |
|
| 2003 |
Bergh A, Magnusson BG, Ohlsson J, Wellmar U, Nilsson UJ. Didecyl squarate--a practical amino-reactive cross-linking reagent for neoglycoconjugate synthesis. Glycoconjugate Journal. 18: 615-21. PMID 12376726 DOI: 10.1023/A:1020639603070 |
0.364 |
|
| 2003 |
Nilsson U, Bhattacharyya S, Toftered J. Synthesis of Rigid Polycyclic
Secondary Diamines: Bis-(2,3:6,7-Iminodimethylene)anthracene
and Bis-(2,3:6,7-Iminodimethylene)-9,10-dicarboxyethenoanthracene Synlett. 2003. DOI: 10.1055/S-2003-40359 |
0.333 |
|
| 2003 |
Ohlsson J, Nilsson UJ. A galabiose-based two-dimensional scaffold for the synthesis of inhibitors targeting Pk- and P-antigen binding proteins Tetrahedron Letters. 44: 2785-2787. DOI: 10.1016/S0040-4039(03)00475-1 |
0.385 |
|
| 2002 |
Ohlsson J, Jass J, Uhlin BE, Kihlberg J, Nilsson UJ. Discovery of potent inhibitors of PapG adhesins from uropathogenic Escherichia coli through synthesis and evaluation of galabiose derivatives. Chembiochem : a European Journal of Chemical Biology. 3: 772-9. PMID 12203976 DOI: 10.1002/1439-7633(20020802)3:8<772::Aid-Cbic772>3.0.Co;2-8 |
0.34 |
|
| 2002 |
Sörme P, Qian Y, Nyholm PG, Leffler H, Nilsson UJ. Low micromolar inhibitors of galectin-3 based on 3'-derivatization of N-acetyllactosamine. Chembiochem : a European Journal of Chemical Biology. 3: 183-9. PMID 11921396 DOI: 10.1002/1439-7633(20020301)3:2/3<183::Aid-Cbic183>3.0.Co;2-# |
0.4 |
|
| 2002 |
Hossain N, Zapata A, Wilstermann M, Nilsson UJ, Magnusson G. Synthesis of GD3-lactam: a potential ligand for the development of an anti-melanoma vaccine. Carbohydrate Research. 337: 569-80. PMID 11909589 DOI: 10.1016/S0008-6215(02)00036-8 |
0.64 |
|
| 2002 |
Ercegovic T, Nilsson UJ, Magnusson G. A study of the donor properties of sialyl phosphites having an auxiliary 3-(S)-phenylseleno group. Carbohydrate Research. 331: 255-63. PMID 11383895 DOI: 10.1016/S0008-6215(01)00029-5 |
0.344 |
|
| 2002 |
Billing J, Grundberg H, Nilsson U. Amphiphilic Anthracene-Amino Acid Conjugates as Simple Carbohydrate Receptors in Water Supramolecular Chemistry. 14: 367-372. DOI: 10.1080/10610270290029281 |
0.316 |
|
| 2001 |
Bhattacharyya S, Magnusson BG, Wellmar U, Nilsson UJ. The p-methoxybenzyl ether as an in situ-removable carbohydrate-protecting group: a simple one-pot synthesis of the globotetraose tetrasaccharide Journal of the Chemical Society-Perkin Transactions 1. 886-890. DOI: 10.1039/B009448J |
0.34 |
|
| 2000 |
Sandström C, Magnusson G, Nilsson U, Kenne L. Comparative 1H NMR study of hydroxy protons in galabioside and its S-linked 4-thiodisaccharide analogue in aqueous solution. Carbohydrate Research. 322: 46-56. PMID 10629948 DOI: 10.1016/S0008-6215(99)00215-3 |
0.601 |
|
| 1998 |
Nilsson UJ, Fournier EJ, Hindsgaul O. Solid-phase extraction on C18 silica as a purification strategy in the solution synthesis of a 1-thio-beta-D-galactopyranoside library. Bioorganic & Medicinal Chemistry. 6: 1563-75. PMID 9801828 DOI: 10.1016/S0968-0896(98)00087-X |
0.548 |
|
| 1997 |
Nilsson UJ, Heerze LD, Liu YC, Armstrong GD, Palcic MM, Hindsgaul O. Immobilization of reducing sugars as toxin binding agents. Bioconjugate Chemistry. 8: 466-71. PMID 9258442 DOI: 10.1021/bc9700603 |
0.487 |
|
| 1996 |
Nilsson U, Striker RT, Hultgren SJ, Magnusson G. PapG adhesin from E. coli J96 recognizes the same saccharide epitope when present on whole bacteria and as isolated protein Bioorganic and Medicinal Chemistry. 4: 1809-1817. PMID 9007266 DOI: 10.1016/S0968-0896(96)00163-0 |
0.62 |
|
| 1996 |
Abdel-Motal UM, Berg L, Bengtsson M, Dahmén J, Kihlberg J, Magnusson G, Nilsson U, Jondal M. Major histocompatibility complex class I binding glycopeptides for the estimation of 'empty' class I molecules. Journal of Immunological Methods. 188: 21-31. PMID 8551035 DOI: 10.1016/0022-1759(96)82888-2 |
0.587 |
|
| 1996 |
Nilsson U, Johansson R, Magnusson G. Synthesis, Conformational Analysis and Comparative Protein Binding of a Galabioside and Its Thioglycoside Analogues Chemistry - a European Journal. 2: 295-302. DOI: 10.1002/Chem.19960020310 |
0.655 |
|
| 1995 |
Nilsson U, Magnusson G. Synthesis of the saccharide moiety of galactosylgloboside (SSEA-3) and its conjugation to bovine serum albumin and Sepharose. Carbohydrate Research. 272: 9-16. PMID 7648586 DOI: 10.1016/0008-6215(95)00044-T |
0.596 |
|
| 1995 |
Striker R, Nilsson U, Stonecipher A, Magnusson G, Hultgren SJ. Structural requirements for the glycolipid receptor of human uropathogenic Escherichia coli Molecular Microbiology. 16: 1021-1029. PMID 7476178 DOI: 10.1111/J.1365-2958.1995.Tb02327.X |
0.624 |
|
| 1994 |
Nilsson U, Ray AK, Magnusson G. Synthesis of the Forssman pentasaccharide and terminal tetra-, tri-, and di-saccharide fragments. Carbohydrate Research. 252: 137-48. PMID 8137357 DOI: 10.1016/0008-6215(94)90011-6 |
0.606 |
|
| 1994 |
Nilsson U, Ray AK, Magnusson G. Synthesis of the globotetraose tetrasaccharide and terminal tri- and di-saccharide fragments. Carbohydrate Research. 252: 117-36. PMID 8137356 DOI: 10.1016/0008-6215(94)90010-8 |
0.61 |
|
| 1994 |
Grönberg G, Nilsson U, Bock K, Magnusson G. Nuclear magnetic resonance and conformational investigations of the pentasaccharide of the Forssman antigen and overlapping di-, tri-, and tetra-saccharide sequences Carbohydrate Research. 257: 35-54. PMID 8004638 DOI: 10.1016/0008-6215(94)84106-3 |
0.592 |
|
| 1994 |
Broddefalk J, Nilsson U, Kihlberg J. An Improved Synthesis of 3,4,6-Tri-O-acetyl-2-azido-2-deoxy-α-d-galactopyranosyl Bromide: A Key Component for Synthesis of Glycopeptides and Glycolipids Journal of Carbohydrate Chemistry. 13: 129-132. DOI: 10.1080/07328309408009183 |
0.354 |
|
| 1992 |
Ray AK, Nilsson U, Magnusson G. Synthesis and conformational analysis of GM3 lactam; a hydrolytically stable analog of GM3 ganglioside lactone Journal of the American Chemical Society. 114: 2256-2257. DOI: 10.1021/Ja00032A049 |
0.316 |
|
| 1990 |
Magnusson G, Ahlfors S, Dahmen J, Jansson K, Nilsson U, Noori G, Stenvall K, Tjoernebo A. Prespacer glycosides in glycoconjugate chemistry. Dibromoisobutyl (DIB) glycosides for the synthesis of neoglycolipids, neoglycoproteins, neoglycoparticles, and soluble glycosides The Journal of Organic Chemistry. 55: 3932-3946. DOI: 10.1021/Jo00299A044 |
0.328 |
|
| 1990 |
Nilsson U, Ray AK, Magnusson G. Efficient syntheses of 3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-β- and -α-d-galactopyranosyl chloride Carbohydrate Research. 208: 260-263. DOI: 10.1016/0008-6215(90)80107-E |
0.598 |
|
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