| Year |
Citation |
Score |
| 2020 |
Rodríguez-Espigares I, Torrens-Fontanals M, Tiemann JKS, Aranda-García D, Ramírez-Anguita JM, Stepniewski TM, Worp N, Varela-Rial A, Morales-Pastor A, Medel-Lacruz B, Pándy-Szekeres G, Mayol E, Giorgino T, Carlsson J, Deupi X, ... ... Weinstein H, et al. Publisher Correction: GPCRmd uncovers the dynamics of the 3D-GPCRome. Nature Methods. PMID 32704182 DOI: 10.1038/S41592-020-0928-3 |
0.514 |
|
| 2020 |
Rodríguez-Espigares I, Torrens-Fontanals M, Tiemann JKS, Aranda-García D, Ramírez-Anguita JM, Stepniewski TM, Worp N, Varela-Rial A, Morales-Pastor A, Medel-Lacruz B, Pándy-Szekeres G, Mayol E, Giorgino T, Carlsson J, Deupi X, ... ... Weinstein H, et al. GPCRmd uncovers the dynamics of the 3D-GPCRome. Nature Methods. PMID 32661425 DOI: 10.1038/S41592-020-0884-Y |
0.591 |
|
| 2020 |
Huang Y, Wang X, Lv G, Razavi AM, Huysmans GHM, Weinstein H, Bracken C, Eliezer D, Boudker O. Use of paramagnetic F NMR to monitor domain movement in a glutamate transporter homolog. Nature Chemical Biology. PMID 32514183 DOI: 10.1038/S41589-020-0561-6 |
0.333 |
|
| 2020 |
Tang B, Li X, Maretzky T, Perez-Aguilar JM, McIlwain D, Xie Y, Zheng Y, Mak TW, Weinstein H, Blobel CP. Substrate-selective protein ectodomain shedding by ADAM17 and iRhom2 depends on their juxtamembrane and transmembrane domains. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 32103528 DOI: 10.1096/Fj.201902649R |
0.339 |
|
| 2020 |
Gotfryd K, Boesen T, Mortensen JS, Khelashvili G, Quick M, Terry DS, Missel JW, LeVine MV, Gourdon P, Blanchard SC, Javitch JA, Weinstein H, Loland CJ, Nissen P, Gether U. X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release. Nature Communications. 11: 1005. PMID 32081981 DOI: 10.1038/S41467-020-14735-W |
0.386 |
|
| 2019 |
Khelashvili G, Cheng X, Falzone ME, Doktorova M, Accardi A, Weinstein H. Membrane lipids are both the substrates and a mechanistically responsive environment of TMEM16 scramblase proteins. Journal of Computational Chemistry. PMID 31750558 DOI: 10.1002/Jcc.26105 |
0.351 |
|
| 2019 |
Khelashvili G, Falzone ME, Cheng X, Lee BC, Accardi A, Weinstein H. Dynamic modulation of the lipid translocation groove generates a conductive ion channel in Ca-bound nhTMEM16. Nature Communications. 10: 4972. PMID 31672969 DOI: 10.1038/S41467-019-12865-4 |
0.369 |
|
| 2019 |
Carrillo-Cabada H, Benson J, Razavi A, Mulligan B, Cuendet MA, Weinstein H, Taufer M, Estrada T. A Graphic Encoding Method for Quantitative Classification of Protein Structure and Representation of Conformational Changes. Ieee/Acm Transactions On Computational Biology and Bioinformatics. PMID 31603792 DOI: 10.1109/Tcbb.2019.2945291 |
0.335 |
|
| 2019 |
LeVine MV, Terry DS, Khelashvili G, Siegel ZS, Quick M, Javitch JA, Blanchard SC, Weinstein H. The allosteric mechanism of substrate-specific transport in SLC6 is mediated by a volumetric sensor. Proceedings of the National Academy of Sciences of the United States of America. PMID 31324743 DOI: 10.1073/Pnas.1903020116 |
0.364 |
|
| 2019 |
Plante A, Shore DM, Morra G, Khelashvili G, Weinstein H. A Machine Learning Approach for the Discovery of Ligand-Specific Functional Mechanisms of GPCRs. Molecules (Basel, Switzerland). 24. PMID 31159491 DOI: 10.3390/Molecules24112097 |
0.346 |
|
| 2019 |
Doktorova M, Heberle FA, Marquardt D, Rusinova R, Sanford RL, Peyear TA, Katsaras J, Feigenson GW, Weinstein H, Andersen OS. Gramicidin Increases Lipid Flip-Flop in Symmetric and Asymmetric Lipid Vesicles. Biophysical Journal. PMID 30755300 DOI: 10.1016/J.Bpj.2019.01.016 |
0.341 |
|
| 2019 |
Doktorova M, LeVine MV, Khelashvili G, Weinstein H. A New Computational Method for Membrane Compressibility: Bilayer Mechanical Thickness Revisited. Biophysical Journal. PMID 30665693 DOI: 10.1016/J.Bpj.2018.12.016 |
0.331 |
|
| 2019 |
Richards R, Mondal S, Weinstein H, Dempski RE. Channelrhodopsin-2 Function is Modulated by Residual Hydrophobic Mismatch with the Surrounding Lipid Environment Applied Sciences. 9: 2674. DOI: 10.3390/App9132674 |
0.554 |
|
| 2018 |
Doktorova M, Weinstein H. Accurate In Silico Modeling of Asymmetric Bilayers Based on Biophysical Principles. Biophysical Journal. PMID 30297133 DOI: 10.1016/J.Bpj.2018.09.008 |
0.35 |
|
| 2018 |
Lee BC, Khelashvili G, Falzone M, Menon AK, Weinstein H, Accardi A. Gating mechanism of the extracellular entry to the lipid pathway in a TMEM16 scramblase. Nature Communications. 9: 3251. PMID 30108217 DOI: 10.1038/S41467-018-05724-1 |
0.341 |
|
| 2018 |
Quick M, Abramyan AM, Wiriyasermkul P, Weinstein H, Shi L, Javitch JA. The LeuT-fold neurotransmitter:sodium symporter MhsT has two substrate sites. Proceedings of the National Academy of Sciences of the United States of America. PMID 30082383 DOI: 10.1073/Pnas.1717444115 |
0.332 |
|
| 2018 |
Herlo R, Lund VK, Lycas MD, Jansen AM, Khelashvili G, Andersen RC, Bhatia V, Pedersen TS, Albornoz PBC, Johner N, Ammendrup-Johnsen I, Christensen NR, Erlendsson S, Stoklund M, Larsen JB, ... Weinstein H, et al. An Amphipathic Helix Directs Cellular Membrane Curvature Sensing and Function of the BAR Domain Protein PICK1. Cell Reports. 23: 2056-2069. PMID 29768204 DOI: 10.1016/J.Celrep.2018.04.074 |
0.352 |
|
| 2018 |
Razavi AM, Khelashvili G, Weinstein H. How structural elements evolving from bacterial to human SLC6 transporters enabled new functional properties. Bmc Biology. 16: 31. PMID 29540172 DOI: 10.1186/S12915-018-0495-6 |
0.338 |
|
| 2018 |
Terry DS, Kolster RA, Quick M, LeVine MV, Khelashvili G, Zhou Z, Weinstein H, Javitch JA, Blanchard SC. A partially-open inward-facing intermediate conformation of LeuT is associated with Na+ release and substrate transport. Nature Communications. 9: 230. PMID 29335402 DOI: 10.1038/S41467-017-02202-Y |
0.393 |
|
| 2018 |
LeVine MV, Cuendet MA, Razavi AM, Khelashvili G, Weinstein H. Thermodynamic Coupling Function Analysis of Allosteric Coupling between Na+ Release and Inward-Opening in the Human Dopamine Transporter Biophysical Journal. 114: 421a. DOI: 10.1016/J.Bpj.2017.11.2331 |
0.302 |
|
| 2018 |
Morra G, Razavi AM, Pandey K, Weinstein H, Menon AK, Khelashvili G. The GPCR Opsin Translocates Lipids via a Dynamic Mechanism Specified by Markov State Model Analysis of Molecular Dynamics Trajectories Biophysical Journal. 114: 274a. DOI: 10.1016/J.Bpj.2017.11.1582 |
0.307 |
|
| 2017 |
Morra G, Razavi AM, Pandey K, Weinstein H, Menon AK, Khelashvili G. Mechanisms of Lipid Scrambling by the G Protein-Coupled Receptor Opsin. Structure (London, England : 1993). PMID 29290486 DOI: 10.1016/J.Str.2017.11.020 |
0.398 |
|
| 2017 |
LeVine MV, Cuendet MA, Razavi AM, Khelashvili G, Weinstein H. Thermodynamic Coupling Function Analysis of Allosteric Mechanisms in the Human Dopamine Transporter. Biophysical Journal. PMID 29153319 DOI: 10.1016/J.Bpj.2017.10.030 |
0.358 |
|
| 2017 |
Gregorio GG, Masureel M, Hilger D, Terry DS, Juette M, Zhao H, Zhou Z, Perez-Aguilar JM, Hauge M, Mathiasen S, Javitch JA, Weinstein H, Kobilka BK, Blanchard SC. Single-molecule analysis of ligand efficacy in β2AR-G-protein activation. Nature. PMID 28607487 DOI: 10.1038/Nature22354 |
0.362 |
|
| 2017 |
Wragg RT, Parisotto DA, Li Z, Terakawa MS, Snead D, Basu I, Weinstein H, Eliezer D, Dittman JS. Evolutionary Divergence of the C-terminal Domain of Complexin Accounts for Functional Disparities between Vertebrate and Invertebrate Complexins. Frontiers in Molecular Neuroscience. 10: 146. PMID 28603484 DOI: 10.3389/Fnmol.2017.00146 |
0.348 |
|
| 2017 |
Stolzenberg S, Li Z, Quick M, Malinauskaite L, Nissen P, Weinstein H, Javitch JA, Shi L. The Role of TM5 in Na2 Release and the Conformational Transition of Neurotransmitter:Sodium Symporters toward the Inward-Open State. The Journal of Biological Chemistry. PMID 28320858 DOI: 10.1074/Jbc.M116.757153 |
0.372 |
|
| 2017 |
Li X, Maretzky T, Perez-Aguilar JM, Monette S, Weskamp G, Le Gall S, Beutler B, Weinstein H, Blobel CP. Structural modeling defines transmembrane residues in ADAM17 that are crucial for Rhbdf2/ADAM17-dependent proteolysis. Journal of Cell Science. PMID 28104813 DOI: 10.1242/Jcs.196436 |
0.329 |
|
| 2017 |
Razavi AM, Khelashvili G, Weinstein H. A Markov State-based Quantitative Kinetic Model of Sodium Release from the Dopamine Transporter. Scientific Reports. 7: 40076. PMID 28059145 DOI: 10.1038/Srep40076 |
0.333 |
|
| 2017 |
Shore DM, Iaea DB, Rusinova R, Khelashvili G, Cuendet MA, Andersen OS, Maxfield FR, Weinstein H. Vectorial Cholesterol Transport by STARD4 is Mediated by Specific PIP 2 Membrane Composition Biophysical Journal. 112: 87a. DOI: 10.1016/J.Bpj.2016.11.511 |
0.349 |
|
| 2017 |
Doktorova M, Khelashvili G, Weinstein H. Calculating Membrane Area Compressibility from MD Simulations: a Novel Computational Framework Biophysical Journal. 112: 467a. DOI: 10.1016/J.Bpj.2016.11.2507 |
0.328 |
|
| 2017 |
Khelashvili G, Cheol Lee B, Falzone M, Menon AK, Accardi A, Weinstein H. Role of Hydrophilic Groove of the TMEM16 Protein in Lipid Scrambling Biophysical Journal. 112: 392a. DOI: 10.1016/J.Bpj.2016.11.2131 |
0.363 |
|
| 2017 |
Khelashvili G, Pandey K, Weinstein H, Menon AK. Molecular Mechanism of Lipid Scrambling by Opsin Biophysical Journal. 112: 391a. DOI: 10.1016/J.Bpj.2016.11.2125 |
0.386 |
|
| 2017 |
Sahai MA, Davidson C, Khelashvili G, Barrese V, Dutta N, Weinstein H, Opacka-Juffry J. Combined in Vitro and in Silico Approaches to the Assessment of Stimulant Properties of Novel Psychoactive Substances Biophysical Journal. 112: 338a-339a. DOI: 10.1016/J.Bpj.2016.11.1833 |
0.725 |
|
| 2016 |
Sahai MA, Davidson C, Khelashvili G, Barrese V, Dutta N, Weinstein H, Opacka-Juffry J. Combined in vitro and in silico approaches to the assessment of stimulant properties of novel psychoactive substances - The case of the benzofuran 5-MAPB. Progress in Neuro-Psychopharmacology & Biological Psychiatry. PMID 27890676 DOI: 10.1016/J.Pnpbp.2016.11.004 |
0.725 |
|
| 2016 |
Cuendet MA, Weinstein H, LeVine MV. The allostery landscape: quantifying thermodynamic couplings in biomolecular systems. Journal of Chemical Theory and Computation. PMID 27766843 DOI: 10.1021/Acs.Jctc.6B00841 |
0.3 |
|
| 2016 |
Khelashvili G, Schmidt SG, Shi L, Javitch JA, Gether U, Loland CJ, Weinstein H. Conformational dynamics on the extracellular side of LeuT controlled by Na+ and K+ ions and the protonation state of E290. The Journal of Biological Chemistry. PMID 27474737 DOI: 10.1074/Jbc.M116.731455 |
0.328 |
|
| 2016 |
LeVine MV, Cuendet MA, Khelashvili G, Weinstein H. Allosteric Mechanisms of Molecular Machines at the Membrane: Transport by Sodium-Coupled Symporters. Chemical Reviews. PMID 26892914 DOI: 10.1021/Acs.Chemrev.5B00627 |
0.365 |
|
| 2016 |
LeVine MV, Khelashvili G, Shi L, Quick M, Javitch JA, Weinstein H. The role of annular lipids in the functional properties of leucine transporter LeuT proteomicelles. Biochemistry. PMID 26811944 DOI: 10.1021/Acs.Biochem.5B01268 |
0.399 |
|
| 2016 |
Stolzenberg S, Michino M, LeVine MV, Weinstein H, Shi L. Computational approaches to detect Allosteric pathways in Transmembrane Molecular Machines. Biochimica Et Biophysica Acta. PMID 26806157 DOI: 10.1016/J.Bbamem.2016.01.010 |
0.409 |
|
| 2016 |
Arango-Lievano M, Sensoy O, Borie A, Corbani M, Guillon G, Sokoloff P, Weinstein H, Jeanneteau F. A GIPC1-palmitate switch modulates dopamine Drd3 receptor trafficking and signaling. Molecular and Cellular Biology. PMID 26787837 DOI: 10.1128/Mcb.00916-15 |
0.364 |
|
| 2016 |
Cuendet MA, Weinstein H. Dissecting Functional Correlates of a Double Mutation Enhancing GltPh Transport Efficiency using Alchemical Free Energy Calculations Biophysical Journal. 110. DOI: 10.1016/J.Bpj.2015.11.3360 |
0.377 |
|
| 2016 |
Doktorova M, Feigenson GW, Weinstein H. The Interaction of Proteins with Asymmetric Lipid Bilayers Biophysical Journal. 110: 419a. DOI: 10.1016/J.Bpj.2015.11.2265 |
0.36 |
|
| 2016 |
LeVine MV, Cuendet MA, Khelashvili G, Weinstein H. From Physics to Phenotype: New Insights into Allosteric Transport Mechanisms in LeuT Biophysical Journal. 110: 362a. DOI: 10.1016/J.Bpj.2015.11.1950 |
0.389 |
|
| 2016 |
Stern CD, Perez-Aguilar JM, Blanchard SC, Weinstein H, Chodera JD. Bridging the Gap between Computation and Experiments in GPCRs Biophysical Journal. 110: 324a-325a. DOI: 10.1016/J.Bpj.2015.11.1743 |
0.337 |
|
| 2015 |
LeVine MV, Weinstein H. AIM for Allostery: Using the Ising Model to Understand Information Processing and Transmission in Allosteric Biomolecular Systems. Entropy (Basel, Switzerland). 17: 2895-2918. PMID 26594108 DOI: 10.3390/E17052895 |
0.372 |
|
| 2015 |
Billesbølle CB, Krüger MB, Shi L, Quick M, Li Z, Stolzenberg S, Kniazeff J, Gotfryd K, Mortensen JS, Javitch JA, Weinstein H, Loland CJ, Gether U. Substrate-induced unlocking of the inner gate determines the catalytic efficiency of a neurotransmitter:sodium symporter. The Journal of Biological Chemistry. PMID 26363074 DOI: 10.1074/Jbc.M115.677658 |
0.391 |
|
| 2015 |
Khelashvili G, Stanley N, Sahai MA, Medina J, LeVine MV, Shi L, De Fabritiis G, Weinstein H. Spontaneous Inward Opening of the Dopamine Transporter Is Triggered by PIP2-Regulated Dynamics of the N-Terminus. Acs Chemical Neuroscience. PMID 26255829 DOI: 10.1021/Acschemneuro.5B00179 |
0.74 |
|
| 2015 |
Karlsen ML, Thorsen TS, Johner N, Ammendrup-Johnsen I, Erlendsson S, Tian X, Simonsen JB, Høiberg-Nielsen R, Christensen NM, Khelashvili G, Streicher W, Teilum K, Vestergaard B, Weinstein H, Gether U, et al. Structure of Dimeric and Tetrameric Complexes of the BAR Domain Protein PICK1 Determined by Small-Angle X-Ray Scattering. Structure (London, England : 1993). PMID 26073603 DOI: 10.1016/J.Str.2015.04.020 |
0.338 |
|
| 2015 |
Stolzenberg S, Quick M, Zhao C, Gotfryd K, Khelashvili G, Gether U, Loland CJ, Javitch JA, Noskov S, Weinstein H, Shi L. Mechanism of the Association between Na+ Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium Symporters. The Journal of Biological Chemistry. 290: 13992-4003. PMID 25869126 DOI: 10.1074/Jbc.M114.625343 |
0.384 |
|
| 2015 |
Khelashvili G, Weinstein H. Functional mechanisms of neurotransmitter transporters regulated by lipid-protein interactions of their terminal loops. Biochimica Et Biophysica Acta. 1848: 1765-74. PMID 25847498 DOI: 10.1016/J.Bbamem.2015.03.025 |
0.397 |
|
| 2015 |
Khelashvili G, Doktorova M, Sahai MA, Johner N, Shi L, Weinstein H. Computational modeling of the N-terminus of the human dopamine transporter and its interaction with PIP2 -containing membranes. Proteins. 83: 952-69. PMID 25739722 DOI: 10.1002/Prot.24792 |
0.737 |
|
| 2015 |
Akyuz N, Georgieva ER, Zhou Z, Stolzenberg S, Cuendet MA, Khelashvili G, Altman RB, Terry DS, Freed JH, Weinstein H, Boudker O, Blanchard SC. Transport domain unlocking sets the uptake rate of an aspartate transporter. Nature. 518: 68-73. PMID 25652997 DOI: 10.1038/Nature14158 |
0.338 |
|
| 2015 |
Sensoy O, Weinstein H. A mechanistic role of Helix 8 in GPCRs: Computational modeling of the dopamine D2 receptor interaction with the GIPC1-PDZ-domain. Biochimica Et Biophysica Acta. 1848: 976-83. PMID 25592838 DOI: 10.1016/J.Bbamem.2014.12.002 |
0.416 |
|
| 2015 |
LeVine MV, Khelashvili G, Shi L, Quick M, Javitch J, Weinstein H. The Role of Annular Lipids in the Mechanism of Membrane Protein Solubilization and Formation of Functionally Competent Proteomicelles Biophysical Journal. 108: 461a. DOI: 10.1016/J.Bpj.2014.11.2517 |
0.393 |
|
| 2015 |
LeVine MV, Khelashvili G, Weinstein H. Simultaneous Identification, Visualization, and Comparison of Complex Events in Molecular Dynamics Simulations Biophysical Journal. 108: 379a-380a. DOI: 10.1016/J.Bpj.2014.11.2082 |
0.337 |
|
| 2015 |
Li Z, Stolzenberg S, Quick M, Malinauskaite L, Nissen P, Weinstein H, Javitch JA, Shi L. A Key Role for TM5 in the Na+-Coupled Alternating-Access Mechanism Revealed by Computational Analysis of the MhsT Structures Biophysical Journal. 108: 29a. DOI: 10.1016/J.Bpj.2014.11.182 |
0.407 |
|
| 2015 |
Khelashvili G, Doktorova M, Sahai MA, Johner N, Shi L, Weinstein H. Computational Modeling of the N-Terminus of the Human Dopamine Transporter (hDAT) Biophysical Journal. 108: 252a. DOI: 10.1016/J.Bpj.2014.11.1394 |
0.738 |
|
| 2015 |
Cuendet MA, Stolzenberg S, Khelashvili G, Weinstein H. Molecular Dynamics Simulation Study of a Mutant Construct of the Archaeal Glutamate Transporter GltPh with Transport Rates as Fast as its Human Counterpart Biophysical Journal. 108: 198a. DOI: 10.1016/J.Bpj.2014.11.1092 |
0.376 |
|
| 2014 |
Handschuh K, Feenstra J, Koss M, Ferretti E, Risolino M, Zewdu R, Sahai MA, Bénazet JD, Peng XP, Depew MJ, Quintana L, Sharpe J, Wang B, Alcorn H, Rivi R, ... ... Weinstein H, et al. ESCRT-II/Vps25 constrains digit number by endosome-mediated selective modulation of FGF-SHH signaling. Cell Reports. 9: 674-87. PMID 25373905 DOI: 10.1016/J.Celrep.2014.09.019 |
0.687 |
|
| 2014 |
Perez-Aguilar JM, Shan J, LeVine MV, Khelashvili G, Weinstein H. A functional selectivity mechanism at the serotonin-2A GPCR involves ligand-dependent conformations of intracellular loop 2. Journal of the American Chemical Society. 136: 16044-54. PMID 25314362 DOI: 10.1021/Ja508394X |
0.352 |
|
| 2014 |
Borre L, Andreassen TF, Shi L, Weinstein H, Gether U. The second sodium site in the dopamine transporter controls cation permeation and is regulated by chloride. The Journal of Biological Chemistry. 289: 25764-73. PMID 25063810 DOI: 10.1074/Jbc.M114.574269 |
0.33 |
|
| 2014 |
Hansen FH, Skjørringe T, Yasmeen S, Arends NV, Sahai MA, Erreger K, Andreassen TF, Holy M, Hamilton PJ, Neergheen V, Karlsborg M, Newman AH, Pope S, Heales SJ, Friberg L, ... ... Weinstein H, et al. Missense dopamine transporter mutations associate with adult parkinsonism and ADHD. The Journal of Clinical Investigation. 124: 3107-20. PMID 24911152 DOI: 10.1172/Jci73778 |
0.699 |
|
| 2014 |
Mondal S, Khelashvili G, Weinstein H. Not just an oil slick: how the energetics of protein-membrane interactions impacts the function and organization of transmembrane proteins. Biophysical Journal. 106: 2305-16. PMID 24896109 DOI: 10.1016/J.Bpj.2014.04.032 |
0.585 |
|
| 2014 |
Hamilton PJ, Belovich AN, Khelashvili G, Saunders C, Erreger K, Javitch JA, Sitte HH, Weinstein H, Matthies HJ, Galli A. PIP2 regulates psychostimulant behaviors through its interaction with a membrane protein. Nature Chemical Biology. 10: 582-9. PMID 24880859 DOI: 10.1038/Nchembio.1545 |
0.37 |
|
| 2014 |
LeVine MV, Weinstein H. NbIT--a new information theory-based analysis of allosteric mechanisms reveals residues that underlie function in the leucine transporter LeuT. Plos Computational Biology. 10: e1003603. PMID 24785005 DOI: 10.1371/Journal.Pcbi.1003603 |
0.375 |
|
| 2014 |
Kazmier K, Sharma S, Quick M, Islam SM, Roux B, Weinstein H, Javitch JA, McHaourab HS. Conformational dynamics of ligand-dependent alternating access in LeuT. Nature Structural & Molecular Biology. 21: 472-9. PMID 24747939 DOI: 10.1038/Nsmb.2816 |
0.388 |
|
| 2014 |
Dehnes Y, Shan J, Beuming T, Shi L, Weinstein H, Javitch JA. Conformational changes in dopamine transporter intracellular regions upon cocaine binding and dopamine translocation. Neurochemistry International. 73: 4-15. PMID 24576496 DOI: 10.1016/J.Neuint.2014.02.003 |
0.692 |
|
| 2014 |
Johner N, Mondal S, Morra G, Caffrey M, Weinstein H, Khelashvili G. Protein and lipid interactions driving molecular mechanisms of in meso crystallization. Journal of the American Chemical Society. 136: 3271-84. PMID 24494670 DOI: 10.1021/Ja4129839 |
0.519 |
|
| 2014 |
Mondal S, Khelashvili G, Johner N, Weinstein H. How the dynamic properties and functional mechanisms of GPCRs are modulated by their coupling to the membrane environment Advances in Experimental Medicine and Biology. 796: 55-74. PMID 24158801 DOI: 10.1007/978-94-007-7423-0_4 |
0.591 |
|
| 2014 |
Johner N, Mondal S, Morra G, Caffrey M, Weinstein H, Khelashvili G. Protein and lipid interactions driving molecular mechanisms of in meso crystallization Journal of the American Chemical Society. 136: 3271-3284. DOI: 10.1021/ja4129839 |
0.471 |
|
| 2014 |
Mondal S, Khelashvili G, Weinstein H. Not just an oil slick: How the energetics of protein-membrane interactions impacts the function and organization of transmembrane proteins Biophysical Journal. 106: 2305-2316. DOI: 10.1016/j.bpj.2014.04.032 |
0.461 |
|
| 2014 |
Mondal S, Khelashvili G, Johner N, Weinstein H. How the dynamic properties and functionalmechanisms of GPCRs aremodulated by their coupling to themembrane environment Advances in Experimental Medicine and Biology. 796: 55-74. DOI: 10.1007/978-94-007-7423-0__4 |
0.443 |
|
| 2013 |
Mondal S, Johnston JM, Wang H, Khelashvili G, Filizola M, Weinstein H. Membrane driven spatial organization of GPCRs. Scientific Reports. 3: 2909. PMID 24105260 DOI: 10.1038/Srep02909 |
0.682 |
|
| 2013 |
Khelashvili G, LeVine MV, Shi L, Quick M, Javitch JA, Weinstein H. The membrane protein LeuT in micellar systems: aggregation dynamics and detergent binding to the S2 site. Journal of the American Chemical Society. 135: 14266-75. PMID 23980525 DOI: 10.1021/Ja405984V |
0.396 |
|
| 2013 |
Kantcheva AK, Quick M, Shi L, Winther AM, Stolzenberg S, Weinstein H, Javitch JA, Nissen P. Chloride binding site of neurotransmitter sodium symporters. Proceedings of the National Academy of Sciences of the United States of America. 110: 8489-94. PMID 23641004 DOI: 10.1073/Pnas.1221279110 |
0.358 |
|
| 2013 |
Mondal S, Khelashvili G, Shi L, Weinstein H. The cost of living in the membrane: A case study of hydrophobic mismatch for the multi-segment protein LeuT Chemistry and Physics of Lipids. 169: 27-38. PMID 23376428 DOI: 10.1016/J.Chemphyslip.2013.01.006 |
0.597 |
|
| 2013 |
Sensoy O, Weinstein H. Structure and Dynamics of Helix-8 in GPCR-PDZ-Domain Interactions Biophysical Journal. 104. DOI: 10.1016/J.Bpj.2012.11.675 |
0.393 |
|
| 2013 |
Khelashvili G, LeVine MV, Shi L, Quick M, Javitch JA, Weinstein H. Like Fish Out of Water: Membrane Proteins in Detergent Micelles Biophysical Journal. 104: 113a. DOI: 10.1016/J.Bpj.2012.11.656 |
0.402 |
|
| 2013 |
Mondal S, Khelashvili G, Shi L, Weinstein H. Functional Consequences of Incomplete Hydrophobic Matching at TM1 of the LeuT Transporter Biophysical Journal. 104: 92a-93a. DOI: 10.1016/J.Bpj.2012.11.553 |
0.6 |
|
| 2013 |
Sahai MA, Burnett B, Stolzenberg S, Shi L, Weinstein H. Path Searching Towards the Symmetric Inward Open Structure of LeuT Biophysical Journal. 104. DOI: 10.1016/J.Bpj.2012.11.354 |
0.734 |
|
| 2013 |
Stolzenberg S, Huang Z, Mondal S, Weinstein H, Tajkhorshid E. Structural Transition between the Inward- and Outward-Facing States of the Glutamate Transporter in Different Lipid Environments Biophysical Journal. 104: 288a. DOI: 10.1016/J.Bpj.2012.11.1612 |
0.594 |
|
| 2013 |
Stolzenberg S, Zhao C, Gracia L, Noskov S, Weinstein H, Shi L. Allostery in the Ion-Controlled Conformational Dynamics of LeuT Biophysical Journal. 104: 287a-288a. DOI: 10.1016/J.Bpj.2012.11.1609 |
0.378 |
|
| 2013 |
Stolzenberg S, Boudker O, Weinstein H. Mechanistic Insights from Modeling the Substrate Translocation Path of the Bacterial Glutamate Transporter Homologue GltPh Biophysical Journal. 104: 199a-200a. DOI: 10.1016/J.Bpj.2012.11.1127 |
0.396 |
|
| 2012 |
Zhao C, Stolzenberg S, Gracia L, Weinstein H, Noskov S, Shi L. Ion-controlled conformational dynamics in the outward-open transition from an occluded state of leut Biophysical Journal. 103: 878-888. PMID 23009837 DOI: 10.1016/J.Bpj.2012.07.044 |
0.365 |
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| 2012 |
Plenge P, Shi L, Beuming T, Te J, Newman AH, Weinstein H, Gether U, Loland CJ. Steric hindrance mutagenesis in the conserved extracellular vestibule impedes allosteric binding of antidepressants to the serotonin transporter. The Journal of Biological Chemistry. 287: 39316-26. PMID 23007398 DOI: 10.1074/Jbc.M112.371765 |
0.682 |
|
| 2012 |
Khelashvili G, Galli A, Weinstein H. Phosphatidylinositol 4,5-biphosphate (PIP(2)) lipids regulate the phosphorylation of syntaxin N-terminus by modulating both its position and local structure. Biochemistry. 51: 7685-98. PMID 22950482 DOI: 10.1021/Bi300833Z |
0.389 |
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| 2012 |
Khelashvili G, Albornoz PBC, Johner N, Mondal S, Caffrey M, Weinstein H. Why GPCRs behave differently in cubic and lamellar lipidic mesophases Journal of the American Chemical Society. 134: 15858-15868. PMID 22931253 DOI: 10.1021/Ja3056485 |
0.557 |
|
| 2012 |
Shan J, Khelashvili G, Mondal S, Mehler EL, Weinstein H. Ligand-dependent conformations and dynamics of the serotonin 5-HT2A receptor determine its activation and membrane-driven oligomerization properties Plos Computational Biology. 8. PMID 22532793 DOI: 10.1371/Journal.Pcbi.1002473 |
0.574 |
|
| 2012 |
Stolzenberg S, Khelashvili G, Weinstein H. Structural intermediates in a model of the substrate translocation path of the bacterial glutamate transporter homologue GltPh. The Journal of Physical Chemistry. B. 116: 5372-83. PMID 22494242 DOI: 10.1021/Jp301726S |
0.407 |
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| 2012 |
Sharma S, Stein RA, Quick M, Stolzenberg S, Shi L, Weinstein H, Javitch JA, Mchaourab HS. Conformational Dynamics in the Transport Cycle of Leucine Transporter on the Extracellular-Side Biophysical Journal. 102: 606a. DOI: 10.1016/J.Bpj.2011.11.3304 |
0.405 |
|
| 2012 |
Kazmier K, Quick M, Shi L, Weinstein H, Javitch JA, Mchaourab HS. Structure, Dynamics, and Mechanism of the Leucine Transporter Studied by Double Electron Electron Resonance Spectroscopy Biophysical Journal. 102: 606a. DOI: 10.1016/J.Bpj.2011.11.3303 |
0.384 |
|
| 2012 |
Stolzenberg S, Khelashvili G, Weinstein H. Structural intermediates in a model of the substrate translocation path of the bacterial glutamate transporter homologue GltPh Journal of Physical Chemistry B. 116: 5372-5383. DOI: 10.1016/J.Bpj.2011.11.2839 |
0.386 |
|
| 2012 |
Mondal S, Khelashvili G, Khangulova (Johnston) J, Wang H, Provasi D, Andersen OS, Filizola M, Weinstein H. Interaction with the Membrane Uncovers Essential Differences Between Highly Homologous GPCRs Biophysical Journal. 102: 514a. DOI: 10.1016/J.Bpj.2011.11.2814 |
0.69 |
|
| 2012 |
Khelashvili G, Mondal S, Caffrey M, Weinstein H. Quantitative Comparison of GPCR Interactions with the Lipid Bilayer of the Cubic and Lamellar Mesophases Biophysical Journal. 102: 467a-468a. DOI: 10.1016/J.Bpj.2011.11.2565 |
0.565 |
|
| 2012 |
Khelashvili G, Galli A, Weinstein H. How PIP2 Lipids Regulate the Position and Phosphorylation of the Syntaxin N-Terminus Biophysical Journal. 102: 433a. DOI: 10.1016/J.Bpj.2011.11.2373 |
0.412 |
|
| 2012 |
Mondal S, Weinstein H, Khelashvili G. Interactions of the cell membrane with integral proteins Comprehensive Biophysics. 9: 229-242. DOI: 10.1016/B978-0-12-374920-8.00927-9 |
0.462 |
|
| 2011 |
Mondal S, Khelashvili G, Shan J, Andersen OS, Weinstein H. Quantitative modeling of membrane deformations by multihelical membrane proteins: application to G-protein coupled receptors. Biophysical Journal. 101: 2092-101. PMID 22067146 DOI: 10.1016/J.Bpj.2011.09.037 |
0.575 |
|
| 2011 |
Weinstein H, Scarlata S. The correlation between multidomain enzymes and multiple activation mechanisms- the case of phospholipase Cβ and its membrane interactions Biochimica Et Biophysica Acta - Biomembranes. 1808: 2940-2947. PMID 21906583 DOI: 10.1016/J.Bbamem.2011.08.028 |
0.334 |
|
| 2011 |
Han DS, Golebiewska U, Stolzenberg S, Scarlata SF, Weinstein H. A dynamic model of membrane-bound phospholipase Cβ2 activation by Gβγ subunits Molecular Pharmacology. 80: 434-445. PMID 21693623 DOI: 10.1124/Mol.111.073403 |
0.382 |
|
| 2011 |
Shan J, Javitch JA, Shi L, Weinstein H. The substrate-driven transition to an inward-facing conformation in the functional mechanism of the dopamine transporter. Plos One. 6: e16350. PMID 21298009 DOI: 10.1371/Journal.Pone.0016350 |
0.301 |
|
| 2011 |
Shan J, Javitch JA, Shi L, Weinstein H. The substrate-driven transition to an inward-facing conformation in the functional mechanism of the dopamine transporter. Plos One. 6: e16350. PMID 21298009 DOI: 10.1371/Journal.Pone.0016350 |
0.301 |
|
| 2011 |
Bisgaard H, Larsen MA, Mazier S, Beuming T, Newman AH, Weinstein H, Shi L, Loland CJ, Gether U. The binding sites for benztropines and dopamine in the dopamine transporter overlap. Neuropharmacology. 60: 182-90. PMID 20816875 DOI: 10.1016/J.Neuropharm.2010.08.021 |
0.669 |
|
| 2011 |
Bisgaard H, Larsen MA, Mazier S, Beuming T, Newman AH, Weinstein H, Shi L, Loland CJ, Gether U. The binding sites for benztropines and dopamine in the dopamine transporter overlap. Neuropharmacology. 60: 182-90. PMID 20816875 DOI: 10.1016/J.Neuropharm.2010.08.021 |
0.669 |
|
| 2011 |
Mondal S, Khelashvili G, Shan J, Shi L, Andersen O, Weinstein H. Quantitative Analysis of Membrane Deformation by Multi-Helical Transmembrane Proteins Biophysical Journal. 100: 492a. DOI: 10.1016/J.Bpj.2010.12.2883 |
0.578 |
|
| 2011 |
Shan J, Khelashvili G, Mondal S, Weinstein H. Pharmacologically Distinct Ligands Induce Different States of 5-HT2AR and Trigger Different Membrane Remodeling: Implications For GPCR Oligomerization Biophysical Journal. 100: 254a. DOI: 10.1016/J.Bpj.2010.12.1605 |
0.58 |
|
| 2010 |
Shi L, Weinstein H. Conformational rearrangements to the intracellular open states of the LeuT and ApcT transporters are modulated by common mechanisms. Biophysical Journal. 99: L103-5. PMID 21156121 DOI: 10.1016/J.Bpj.2010.10.003 |
0.388 |
|
| 2010 |
Khelashvili G, Mondal S, Andersen OS, Weinstein H. Cholesterol modulates the membrane effects and spatial organization of membrane-penetrating ligands for G-protein coupled receptors. The Journal of Physical Chemistry. B. 114: 12046-57. PMID 20804205 DOI: 10.1021/Jp106373R |
0.568 |
|
| 2010 |
Bach A, Stuhr-Hansen N, Thorsen TS, Bork N, Moreira IS, Frydenvang K, Padrah S, Christensen SB, Madsen KL, Weinstein H, Gether U, Strømgaard K. Structure-activity relationships of a small-molecule inhibitor of the PDZ domain of PICK1 Organic and Biomolecular Chemistry. 8: 4281-4288. PMID 20668766 DOI: 10.1039/C0Ob00025F |
0.366 |
|
| 2010 |
Thorsen TS, Madsen KL, Rebola N, Rathje M, Anggono V, Bach A, Moreira IS, Stuhr-Hansen N, Dyhring T, Peters D, Beuming T, Huganir R, Weinstein H, Mulle C, Strømgaard K, et al. Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD. Proceedings of the National Academy of Sciences of the United States of America. 107: 413-8. PMID 20018661 DOI: 10.1073/Pnas.0902225107 |
0.66 |
|
| 2010 |
Thorsen TS, Madsen KL, Rebola N, Rathje M, Anggono V, Bach A, Moreira IS, Stuhr-Hansen N, Dyhring T, Peters D, Beuming T, Huganir R, Weinstein H, Mulle C, Strømgaard K, et al. Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD. Proceedings of the National Academy of Sciences of the United States of America. 107: 413-8. PMID 20018661 DOI: 10.1073/Pnas.0902225107 |
0.66 |
|
| 2010 |
Gjyrezi A, Gümüş ZH, Wyngaert IVd, Talloen W, Göhlmann HWH, Weinstein H, Giannakakou P. Abstract 115: An integrated framework of transcriptome analysis leads to mechanistic insights into the FTI/Taxol synergy Cancer Research. 70: 115-115. DOI: 10.1158/1538-7445.Am10-115 |
0.316 |
|
| 2010 |
Shi L, Srdanovic M, Beuming T, Skrabanek L, Javitch JA, Weinstein H. TRAC - A platform for structure-function studies of NSS-proteins integrates information from bioinformatics and biomedical literature 10th Ieee International Conference On Bioinformatics and Bioengineering 2010, Bibe 2010. 267-272. DOI: 10.1109/BIBE.2010.51 |
0.624 |
|
| 2010 |
Shi L, Weinstein H. The Allosteric Role of Ion Binding in the Functional Mechanisms of Transporters With LeuT Fold Biophysical Journal. 98: 687a. DOI: 10.1016/J.Bpj.2009.12.3774 |
0.389 |
|
| 2010 |
Moreira I, Ge X, Madsen KL, Gether U, Weinstein H. Design and Characterization of Small Molecule Inhibitors of the PICK1 PDZ Domain with Binding Free Energy Calculations Biophysical Journal. 98. DOI: 10.1016/J.Bpj.2009.12.2319 |
0.581 |
|
| 2010 |
Shan J, Khelashvili G, Weinstein H. Large-Scale MD Simulations Reveal Structural Elements of the Activated State in the 5-HT2a Receptor and their Relation to Cholesterol Dynamics Biophysical Journal. 98: 419a. DOI: 10.1016/J.Bpj.2009.12.2264 |
0.384 |
|
| 2009 |
Khelashvili G, Harries D, Weinstein H. Modeling membrane deformations and lipid demixing upon protein-membrane interaction: the BAR dimer adsorption. Biophysical Journal. 97: 1626-35. PMID 19751667 DOI: 10.1016/J.Bpj.2009.07.006 |
0.341 |
|
| 2009 |
Han Y, Moreira IS, Urizar E, Weinstein H, Javitch JA. Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation. Nature Chemical Biology. 5: 688-95. PMID 19648932 DOI: 10.1038/Nchembio.199 |
0.352 |
|
| 2009 |
Quick M, Winther AM, Shi L, Nissen P, Weinstein H, Javitch JA. Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation. Proceedings of the National Academy of Sciences of the United States of America. 106: 5563-8. PMID 19307590 DOI: 10.1073/Pnas.0811322106 |
0.359 |
|
| 2009 |
Khelashvili G, Grossfield A, Feller SE, Pitman MC, Weinstein H. Structural and dynamic effects of cholesterol at preferred sites of interaction with rhodopsin identified from microsecond length molecular dynamics simulations. Proteins. 76: 403-17. PMID 19173312 DOI: 10.1002/Prot.22355 |
0.375 |
|
| 2009 |
Guptaroy B, Zhang M, Bowton E, Binda F, Shi L, Weinstein H, Galli A, Javitch JA, Neubig RR, Gnegy ME. A juxtamembrane mutation in the N terminus of the dopamine transporter induces preference for an inward-facing conformation. Molecular Pharmacology. 75: 514-24. PMID 19098122 DOI: 10.1124/Mol.108.048744 |
0.329 |
|
| 2009 |
Ericksen SS, Cummings DF, Weinstein H, Schetz JA. Ligand selectivity of D2 dopamine receptors is modulated by changes in local dynamics produced by sodium binding. The Journal of Pharmacology and Experimental Therapeutics. 328: 40-54. PMID 18849360 DOI: 10.1124/Jpet.108.141531 |
0.359 |
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| 2009 |
Chang CW, Poteet E, Schetz JA, Gümüş ZH, Weinstein H. Towards a quantitative representation of the cell signaling mechanisms of hallucinogens: measurement and mathematical modeling of 5-HT1A and 5-HT2A receptor-mediated ERK1/2 activation. Neuropharmacology. 56: 213-25. PMID 18762202 DOI: 10.1016/J.Neuropharm.2008.07.049 |
0.321 |
|
| 2009 |
Khelashvili G, Harries D, Weinstein H. Adsorption Of Bar-domain Proteins To Charged Lipid Membranes Causes Deformations And Lipid Demixing Biophysical Journal. 96: 95a. DOI: 10.1016/J.Bpj.2008.12.401 |
0.331 |
|
| 2009 |
Sun J, Weinstein H. Modeling Orientation-Constrained Reactions: A Study Of Crowding Effects With Brownian Dynamics Simulation Biophysical Journal. 96. DOI: 10.1016/J.Bpj.2008.12.343 |
0.33 |
|
| 2009 |
Shan J, Dehnes Y, Jonathan JA, Shi L, Weinstein H. The Substrate Translocation Pathway and Transport Mechanism in the Dopamine Transporter Biophysical Journal. 96: 594a. DOI: 10.1016/J.Bpj.2008.12.3171 |
0.393 |
|
| 2009 |
Bhatia A, Shi L, Weinstein H. Probing the Cytoplasmic Substrate Permeation Pathway of the Serotonin Transporter with Steered Molecular Dynamics Simulation Biophysical Journal. 96: 68a-69a. DOI: 10.1016/J.Bpj.2008.12.255 |
0.407 |
|
| 2009 |
Shan J, Mehler EL, Weinstein H. Probing the Dynamic Structure and Function of Intracellular Loop 2 in Structurally Cognate GPCRs Biophysical Journal. 96: 4-9. DOI: 10.1016/J.Bpj.2008.12.2200 |
0.343 |
|
| 2009 |
Claxton D, Quick M, Shi L, Chung L, Zhao Y, Weinstein H, Javitch JA, Mchaourab HS. Conformational Cycle Of A Bacterial Homolog Of Human Neurotransmitter Sodium Symporters Biophysical Journal. 96: 195a. DOI: 10.1016/J.Bpj.2008.12.1046 |
0.376 |
|
| 2009 |
Pardo L, Mazurek AP, Osman R, Weinstein H. Theoretical studies of the activation mechanism of histamine H2-receptors: Dimaprit and the receptor model International Journal of Quantum Chemistry. 36: 281-290. DOI: 10.1002/Qua.560360722 |
0.348 |
|
| 2009 |
Mazurek AP, Topiol S, Weinstein H, Osman R. Theoretical studies on the activation mechanism of the histamine H2-receptor: The guanidine substitution and its role in the partial agonism of N(alpha)-guanylhistamine International Journal of Quantum Chemistry. 24: 293-300. DOI: 10.1002/Qua.560240728 |
0.336 |
|
| 2009 |
Weinstein H, Osman R, Edwards WD, Green JP. Theoretical models for molecular mechanisms in biological systems: Tryptamine congeners acting on an LSD—Serotonin receptor International Journal of Quantum Chemistry. 14: 449-461. DOI: 10.1002/Qua.560140742 |
0.335 |
|
| 2009 |
Weinstein H, Chou D, Kang S, Johnson CL, Green JP. Reactivity characteristics of large molecules and their biological activity: Indolealkylamines on the LSD/serotonin receptor International Journal of Quantum Chemistry. 10: 135-150. DOI: 10.1002/Qua.560100717 |
0.371 |
|
| 2008 |
Shi L, Quick M, Zhao Y, Weinstein H, Javitch JA. The mechanism of a neurotransmitter:sodium symporter--inward release of Na+ and substrate is triggered by substrate in a second binding site. Molecular Cell. 30: 667-77. PMID 18570870 DOI: 10.1016/J.Molcel.2008.05.008 |
0.349 |
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| 2008 |
Beuming T, Kniazeff J, Bergmann ML, Shi L, Gracia L, Raniszewska K, Newman AH, Javitch JA, Weinstein H, Gether U, Loland CJ. The binding sites for cocaine and dopamine in the dopamine transporter overlap. Nature Neuroscience. 11: 780-9. PMID 18568020 DOI: 10.1038/Nn.2146 |
0.666 |
|
| 2008 |
Han DS, Wang SX, Weinstein H. Active state-like conformational elements in the beta2-AR and a photoactivated intermediate of rhodopsin identified by dynamic properties of GPCRs. Biochemistry. 47: 7317-21. PMID 18558776 DOI: 10.1021/Bi800442G |
0.334 |
|
| 2008 |
Madsen KL, Eriksen J, Milan-Lobo L, Han DS, Niv MY, Ammendrup-Johnsen I, Henriksen U, Bhatia VK, Stamou D, Sitte HH, McMahon HT, Weinstein H, Gether U. Membrane localization is critical for activation of the PICK1 BAR domain. Traffic (Copenhagen, Denmark). 9: 1327-43. PMID 18466293 DOI: 10.1111/J.1600-0854.2008.00761.X |
0.342 |
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| 2008 |
Kniazeff J, Shi L, Loland CJ, Javitch JA, Weinstein H, Gether U. An intracellular interaction network regulates conformational transitions in the dopamine transporter. The Journal of Biological Chemistry. 283: 17691-701. PMID 18426798 DOI: 10.1074/Jbc.M800475200 |
0.404 |
|
| 2008 |
Taylor MS, Fung HK, Rajgaria R, Filizola M, Weinstein H, Floudas CA. Mutations affecting the oligomerization interface of G-protein-coupled receptors revealed by a novel de novo protein design framework. Biophysical Journal. 94: 2470-81. PMID 18178645 DOI: 10.1529/Biophysj.107.117622 |
0.601 |
|
| 2008 |
Khelashvili G, Weinstein H, Harries D. Protein diffusion on charged membranes: a dynamic mean-field model describes time evolution and lipid reorganization. Biophysical Journal. 94: 2580-97. PMID 18065451 DOI: 10.1529/Biophysj.107.120667 |
0.318 |
|
| 2007 |
Sun J, Weinstein H. Toward realistic modeling of dynamic processes in cell signaling: quantification of macromolecular crowding effects. The Journal of Chemical Physics. 127: 155105. PMID 17949221 DOI: 10.1063/1.2789434 |
0.306 |
|
| 2007 |
Urban JD, Clarke WP, von Zastrow M, Nichols DE, Kobilka B, Weinstein H, Javitch JA, Roth BL, Christopoulos A, Sexton PM, Miller KJ, Spedding M, Mailman RB. Functional selectivity and classical concepts of quantitative pharmacology. The Journal of Pharmacology and Experimental Therapeutics. 320: 1-13. PMID 16803859 DOI: 10.1124/Jpet.106.104463 |
0.352 |
|
| 2006 |
Niv MY, Skrabanek L, Filizola M, Weinstein H. Modeling activated states of GPCRs: the rhodopsin template. Journal of Computer-Aided Molecular Design. 20: 437-48. PMID 17103019 DOI: 10.1007/S10822-006-9061-3 |
0.621 |
|
| 2006 |
Filizola M, Wang SX, Weinstein H. Dynamic models of G-protein coupled receptor dimers: indications of asymmetry in the rhodopsin dimer from molecular dynamics simulations in a POPC bilayer. Journal of Computer-Aided Molecular Design. 20: 405-16. PMID 17089205 DOI: 10.1007/S10822-006-9053-3 |
0.623 |
|
| 2006 |
Basdevant N, Weinstein H, Ceruso M. Thermodynamic basis for promiscuity and selectivity in protein-protein interactions: PDZ domains, a case study. Journal of the American Chemical Society. 128: 12766-77. PMID 17002371 DOI: 10.1021/Ja060830Y |
0.357 |
|
| 2006 |
Beuming T, Shi L, Javitch JA, Weinstein H. A comprehensive structure-based alignment of prokaryotic and eukaryotic neurotransmitter/Na+ symporters (NSS) aids in the use of the LeuT structure to probe NSS structure and function. Molecular Pharmacology. 70: 1630-42. PMID 16880288 DOI: 10.1124/Mol.106.026120 |
0.693 |
|
| 2006 |
Quick M, Yano H, Goldberg NR, Duan L, Beuming T, Shi L, Weinstein H, Javitch JA. State-dependent conformations of the translocation pathway in the tyrosine transporter Tyt1, a novel neurotransmitter:sodium symporter from Fusobacterium nucleatum. The Journal of Biological Chemistry. 281: 26444-54. PMID 16798738 DOI: 10.1074/Jbc.M602438200 |
0.695 |
|
| 2006 |
Mehler EL, Hassan SA, Kortagere S, Weinstein H. Ab initio computational modeling of loops in G-protein-coupled receptors: lessons from the crystal structure of rhodopsin. Proteins. 64: 673-90. PMID 16729264 DOI: 10.1002/Prot.21022 |
0.364 |
|
| 2006 |
Gracia L, Speidel JA, Weinstein H. New computational approaches for NMR-based drug design: A protocol for ligand docking to flexible target sites Aip Conference Proceedings. 851: 176-179. DOI: 10.1063/1.2345634 |
0.748 |
|
| 2005 |
Weinstein H. Hallucinogen actions on 5-HT receptors reveal distinct mechanisms of activation and signaling by G protein-coupled receptors. The Aaps Journal. 7: E871-84. PMID 16594640 DOI: 10.1208/Aapsj070485 |
0.345 |
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| 2005 |
Guo W, Shi L, Filizola M, Weinstein H, Javitch JA. Crosstalk in G protein-coupled receptors: changes at the transmembrane homodimer interface determine activation. Proceedings of the National Academy of Sciences of the United States of America. 102: 17495-500. PMID 16301531 DOI: 10.1073/Pnas.0508950102 |
0.602 |
|
| 2005 |
Sen N, Shi L, Beuming T, Weinstein H, Javitch JA. A pincer-like configuration of TM2 in the human dopamine transporter is responsible for indirect effects on cocaine binding. Neuropharmacology. 49: 780-90. PMID 16216288 DOI: 10.1016/J.Neuropharm.2005.08.014 |
0.698 |
|
| 2005 |
Niv MY, Weinstein H. A flexible docking procedure for the exploration of peptide binding selectivity to known structures and homology models of PDZ domains. Journal of the American Chemical Society. 127: 14072-9. PMID 16201829 DOI: 10.1021/Ja054195S |
0.352 |
|
| 2005 |
Filizola M, Weinstein H. The structure and dynamics of GPCR oligomers: a new focus in models of cell-signaling mechanisms and drug design. Current Opinion in Drug Discovery & Development. 8: 577-84. PMID 16159019 |
0.557 |
|
| 2005 |
Filizola M, Weinstein H. The study of G-protein coupled receptor oligomerization with computational modeling and bioinformatics. The Febs Journal. 272: 2926-38. PMID 15955053 DOI: 10.1111/J.1742-4658.2005.04730.X |
0.62 |
|
| 2005 |
Beuming T, Weinstein H. Modeling membrane proteins based on low-resolution electron microscopy maps: A template for the TM domains of the oxalate transporter OxIT Protein Engineering, Design and Selection. 18: 119-125. PMID 15820982 DOI: 10.1093/Protein/Gzi013 |
0.692 |
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| 2005 |
Madsen KL, Beuming T, Niv MY, Chang CW, Dev KK, Weinstein H, Gether U. Molecular determinants for the complex binding specificity of the PDZ domain in PICK1. The Journal of Biological Chemistry. 280: 20539-48. PMID 15774468 DOI: 10.1074/Jbc.M500577200 |
0.695 |
|
| 2005 |
Beuming T, Skrabanek L, Niv MY, Mukherjee P, Weinstein H. PDZBase: A protein-protein interaction database for PDZ-domains Bioinformatics. 21: 827-828. PMID 15513994 DOI: 10.1093/Bioinformatics/Bti098 |
0.668 |
|
| 2004 |
Ceruso MA, Periole X, Weinstein H. Molecular dynamics simulations of transducin: interdomain and front to back communication in activation and nucleotide exchange. Journal of Molecular Biology. 338: 469-81. PMID 15081806 DOI: 10.1016/J.Jmb.2004.02.064 |
0.33 |
|
| 2004 |
Filizola M, Hassan SA, Artoni A, Coller BS, Weinstein H. Mechanistic insights from a refined three-dimensional model of integrin alphaIIbbeta3. The Journal of Biological Chemistry. 279: 24624-30. PMID 15056669 DOI: 10.1074/Jbc.M400243200 |
0.53 |
|
| 2004 |
Beuming T, Weinstein H. A knowledge-based scale for the analysis and prediction of buried and exposed faces of transmembrane domain proteins Bioinformatics. 20: 1822-1835. PMID 14988128 DOI: 10.1093/Bioinformatics/Bth143 |
0.679 |
|
| 2004 |
Mehler EL, Periole X, Hassan SA, Weinstein H. Key issues in the computational simulation of GPCR function: representation of loop domains. Journal of Computer-Aided Molecular Design. 16: 841-53. PMID 12825797 DOI: 10.1023/A:1023845015343 |
0.419 |
|
| 2004 |
Sankararamakrishnan R, Weinstein H. Surface tension parameterization in molecular dynamics simulations of a phospholipid-bilayer membrane: Calibration and effects Journal of Physical Chemistry B. 108: 11802-11811. DOI: 10.1021/Jp048969N |
0.316 |
|
| 2003 |
Goldberg NR, Beuming T, Soyer OS, Goldstein RA, Weinstein H, Javitch JA. Probing conformational changes in neurotransmitter transporters: a structural context. European Journal of Pharmacology. 479: 3-12. PMID 14612133 DOI: 10.1016/J.Ejphar.2003.08.052 |
0.687 |
|
| 2003 |
Campagne F, Bettler E, Vriend G, Weinstein H. Batch mode generation of residue-based diagrams of proteins. Bioinformatics (Oxford, England). 19: 1854-5. PMID 14512361 DOI: 10.1093/Bioinformatics/Btg236 |
0.323 |
|
| 2003 |
Skrabanek L, Campagne F, Weinstein H. Building protein diagrams on the web with the residue-based diagram editor RbDe. Nucleic Acids Research. 31: 3856-8. PMID 12824436 DOI: 10.1093/Nar/Gkg552 |
0.336 |
|
| 2003 |
Visiers I, Weinstein H, Rudnick G, Stephan MM. A second site rescue mutation partially restores functional expression to the serotonin transporter mutant V382P. Biochemistry. 42: 6784-93. PMID 12779333 DOI: 10.1021/Bi0273415 |
0.349 |
|
| 2003 |
Sun J, Viadiu H, Aggarwal AK, Weinstein H. Energetic and structural considerations for the mechanism of protein sliding along DNA in the nonspecific BamHI-DNA complex. Biophysical Journal. 84: 3317-25. PMID 12719261 DOI: 10.1016/S0006-3495(03)70056-3 |
0.344 |
|
| 2003 |
Hassan SA, Mehler EL, Zhang D, Weinstein H. Molecular dynamics simulations of peptides and proteins with a continuum electrostatic model based on screened Coulomb potentials. Proteins. 51: 109-25. PMID 12596268 DOI: 10.1002/Prot.10330 |
0.359 |
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| 2003 |
Ebersole BJ, Visiers I, Weinstein H, Sealfon SC. Molecular basis of partial agonism: orientation of indoleamine ligands in the binding pocket of the human serotonin 5-HT2A receptor determines relative efficacy. Molecular Pharmacology. 63: 36-43. PMID 12488534 DOI: 10.1124/Mol.63.1.36 |
0.379 |
|
| 2002 |
Filizola M, Weinstein H. Structural models for dimerization of G-protein coupled receptors: the opioid receptor homodimers. Biopolymers. 66: 317-25. PMID 12539260 DOI: 10.1002/Bip.10311 |
0.605 |
|
| 2002 |
Filizola M, Olmea O, Weinstein H. Prediction of heterodimerization interfaces of G-protein coupled receptors with a new subtractive correlated mutation method. Protein Engineering. 15: 881-5. PMID 12538907 DOI: 10.1093/Protein/15.11.881 |
0.619 |
|
| 2002 |
Prioleau C, Visiers I, Ebersole BJ, Weinstein H, Sealfon SC. Conserved helix 7 tyrosine acts as a multistate conformational switch in the 5HT2C receptor. Identification of a novel "locked-on" phenotype and double revertant mutations. The Journal of Biological Chemistry. 277: 36577-84. PMID 12145300 DOI: 10.1074/Jbc.M206223200 |
0.353 |
|
| 2002 |
Ceruso MA, Weinstein H. Structural mimicry of proline kinks: tertiary packing interactions support local structural distortions. Journal of Molecular Biology. 318: 1237-49. PMID 12083514 DOI: 10.1016/S0022-2836(02)00221-8 |
0.356 |
|
| 2002 |
Visiers I, Ballesteros JA, Weinstein H. Three-dimensional representations of G protein-coupled receptor structures and mechanisms. Methods in Enzymology. 343: 329-71. PMID 11665578 DOI: 10.1016/S0076-6879(02)43145-X |
0.357 |
|
| 2002 |
Visiers I, Ebersole BJ, Dracheva S, Ballesteros J, Sealfon SC, Weinstein H. Structural motifs as functional microdomains in G-protein-coupled receptors: Energetic considerations in the mechanism of activation of the serotonin 5-HT2A receptor by disruption of the ionic lock of the arginine cage International Journal of Quantum Chemistry. 88: 65-75. DOI: 10.1002/Qua.10078 |
0.375 |
|
| 2001 |
Huang P, Li J, Chen C, Visiers I, Weinstein H, Liu-Chen LY. Functional role of a conserved motif in TM6 of the rat mu opioid receptor: constitutively active and inactive receptors result from substitutions of Thr6.34(279) with Lys and Asp. Biochemistry. 40: 13501-9. PMID 11695897 DOI: 10.1021/Bi010917Q |
0.332 |
|
| 2001 |
Visiers I, Hassan SA, Weinstein H. Differences in conformational properties of the second intracellular loop (IL2) in 5HT2C receptors modified by RNA editing can account for G protein coupling efficiency Protein Engineering. 14: 409-414. PMID 11477220 DOI: 10.1093/Protein/14.6.409 |
0.345 |
|
| 2001 |
Xu W, Li J, Chen C, Huang P, Weinstein H, Javitch JA, Shi L, de Riel JK, Liu-Chen LY. Comparison of the amino acid residues in the sixth transmembrane domains accessible in the binding-site crevices of mu, delta, and kappa opioid receptors. Biochemistry. 40: 8018-29. PMID 11434771 DOI: 10.1021/Bi002490D |
0.342 |
|
| 2001 |
Max M, Shanker YG, Huang L, Rong M, Liu Z, Campagne F, Weinstein H, Damak S, Margolskee RF. Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac. Nature Genetics. 28: 58-63. PMID 11326277 DOI: 10.1038/Ng0501-58 |
0.303 |
|
| 2001 |
Sansom MS, Weinstein H. Hinges, swivels and switches: the role of prolines in signalling via transmembrane alpha-helices. Trends in Pharmacological Sciences. 21: 445-51. PMID 11121576 DOI: 10.1016/S0165-6147(00)01553-4 |
0.346 |
|
| 2001 |
Pastor N, Weinstein H. Protein-DNA interactions in the initiation of transcription: The Role of Flexibility and Dynamics of the TATA Recognition Sequence and the TATA Box Binding Protein Theoretical and Computational Chemistry. 9: 377-407. DOI: 10.1016/S1380-7323(01)80011-X |
0.329 |
|
| 2000 |
Norregaard L, Visiers I, Loland CJ, Ballesteros J, Weinstein H, Gether U. Structural Probing of a Microdomain in the Dopamine Transporter by Engineering of Artificial Zn2+ Binding Sites† Biochemistry. 39: 15836-15846. PMID 11123909 DOI: 10.1021/Bi0018335 |
0.375 |
|
| 2000 |
Pastor N, Weinstein H, Jamison E, Brenowitz M. A detailed interpretation of OH radical footprints in a TBP-DNA complex reveals the role of dynamics in the mechanism of sequence-specific binding. Journal of Molecular Biology. 304: 55-68. PMID 11071810 DOI: 10.1006/Jmbi.2000.4173 |
0.344 |
|
| 2000 |
Visiers I, Braunheim BB, Weinstein H. Prokink: a protocol for numerical evaluation of helix distortions by proline. Protein Engineering. 13: 603-606. PMID 11054453 DOI: 10.1093/Protein/13.9.603 |
0.351 |
|
| 2000 |
Sankararamakrishnan R, Weinstein H. Molecular dynamics simulations predict a tilted orientation for the helical region of dynorphin A(1-17) in dimyristoylphosphatidylcholine bilayers Biophysical Journal. 79: 2331-2344. PMID 11053113 DOI: 10.1016/S0006-3495(00)76479-4 |
0.356 |
|
| 2000 |
Pardo L, Campillo M, Bosch D, Pastor N, Weinstein H. Binding mechanisms of TATA box-binding proteins: DNA kinking is stabilized by specific hydrogen bonds Biophysical Journal. 78: 1988-1996. PMID 10733977 DOI: 10.1016/S0006-3495(00)76746-4 |
0.302 |
|
| 2000 |
Sankararamakrishnan R, Konvicka K, Mehler EL, Weinstein H. Solvation in simulated annealing and high‐temperature molecular dynamics of proteins: A restrained water droplet model International Journal of Quantum Chemistry. 77: 174-186. DOI: 10.1002/(Sici)1097-461X(2000)77:1<174::Aid-Qua16>3.0.Co;2-C |
0.331 |
|
| 1999 |
Campagne F, Weinstein H. Schematic representation of residue-based protein context-dependent data: An application to transmembrane proteins Journal of Molecular Graphics and Modelling. 17: 207-213. PMID 10736778 DOI: 10.1016/S1093-3263(99)00032-7 |
0.318 |
|
| 1999 |
Flanagan CA, Zhou W, Chi L, Yuen T, Rodic V, Robertson D, Johnson M, Holland P, Millar RP, Weinstein H, Mitchell R, Sealfon SC. The functional microdomain in transmembrane helices 2 and 7 regulates expression, activation, and coupling pathways of the gonadotropin-releasing hormone receptor. The Journal of Biological Chemistry. 274: 28880-6. PMID 10506131 DOI: 10.1074/Jbc.274.41.28880 |
0.358 |
|
| 1999 |
Ri Y, Ballesteros JA, Abrams CK, Oh S, Verselis VK, Weinstein H, Bargiello TA. The role of a conserved proline residue in mediating conformational changes associated with voltage gating of Cx32 gap junctions. Biophysical Journal. 76: 2887-98. PMID 10354417 DOI: 10.1016/S0006-3495(99)77444-8 |
0.309 |
|
| 1999 |
Pastor N, MacKerell AD, Weinstein H. Tit For Tat : The Properties Of Inosine And Adenosine In Tata Box Dna Journal of Biomolecular Structure & Dynamics. 16: 787-810. PMID 10217450 DOI: 10.1080/07391102.1999.10508293 |
0.305 |
|
| 1999 |
Xu W, Ozdener F, Li JG, Chen C, de Riel JK, Weinstein H, Liu-Chen LY. Functional role of the spatial proximity of Asp114(2.50) in TMH 2 and Asn332(7.49) in TMH 7 of the mu opioid receptor. Febs Letters. 447: 318-24. PMID 10214970 DOI: 10.1016/S0014-5793(99)00316-6 |
0.309 |
|
| 1999 |
Duong TH, Mehler EL, Weinstein H. Molecular Dynamics Simulation of Membranes and a Transmembrane Helix Journal of Computational Physics. 151: 358-387. DOI: 10.1006/Jcph.1999.6222 |
0.384 |
|
| 1998 |
Pardo L, Pastor N, Weinstein H. Selective Binding of the TATA Box-Binding Protein to the TATA Box-Containing Promoter: Analysis of Structural and Energetic Factors Biophysical Journal. 75: 2411-2421. PMID 9788936 DOI: 10.1016/S0006-3495(98)77685-4 |
0.325 |
|
| 1998 |
Konvicka K, Guarnieri F, Ballesteros JA, Weinstein H. A Proposed Structure for Transmembrane Segment 7 of G Protein-Coupled Receptors Incorporating an Asn-Pro/Asp-Pro Motif Biophysical Journal. 75: 601-611. PMID 9675163 DOI: 10.1016/S0006-3495(98)77551-4 |
0.393 |
|
| 1998 |
Ballesteros J, Kitanovic S, Guarnieri F, Davies P, Fromme BJ, Konvicka K, Chi L, Millar RP, Davidson JS, Weinstein H, Sealfon SC. Functional microdomains in G-protein-coupled receptors: The conserved arginine-cage motif in the gonadotropin-releasing hormone receptor Journal of Biological Chemistry. 273: 10445-10453. PMID 9553103 DOI: 10.1074/Jbc.273.17.10445 |
0.358 |
|
| 1998 |
Wriggers W, Mehler E, Pitici F, Weinstein H, Schulten K. Structure and dynamics of calmodulin in solution Biophysical Journal. 74: 1622-1639. PMID 9545028 DOI: 10.1016/S0006-3495(98)77876-2 |
0.383 |
|
| 1998 |
Javitch JA, Ballesteros JA, Weinstein H, Chen J. A cluster of aromatic residues in the sixth membrane-spanning segment of the dopamine D2 receptor is accessible in the binding-site crevice. Biochemistry. 37: 998-1006. PMID 9454590 DOI: 10.1021/Bi972241Y |
0.376 |
|
| 1998 |
Kollman P, Weinstein H, Zerner M. Introduction: Theoretical chemistry in biology: From molecular structure to functional mechanisms International Journal of Quantum Chemistry. 69: 1-1. DOI: 10.1002/(Sici)1097-461X(1998)69:1<1::Aid-Qua1>3.0.Co;2-Z |
0.317 |
|
| 1997 |
Strahs D, Weinstein H. Comparative modeling and molecular dynamics studies of the δ, κ and μ opioid receptors Protein Engineering. 10: 1019-1038. PMID 9464566 DOI: 10.1093/Protein/10.9.1019 |
0.403 |
|
| 1997 |
Gether U, Lin S, Ghanouni P, Ballesteros JA, Weinstein H, Kobilka BK. Agonists induce conformational changes in transmembrane domains III and VI of the beta2 adrenoceptor. The Embo Journal. 16: 6737-47. PMID 9362488 DOI: 10.1093/Emboj/16.22.6737 |
0.364 |
|
| 1997 |
Pastor N, Pardo L, Weinstein H. Does TATA matter? A structural exploration of the selectivity determinants in its complexes with TATA box-binding protein Biophysical Journal. 73: 640-652. PMID 9251783 DOI: 10.1016/S0006-3495(97)78099-8 |
0.319 |
|
| 1997 |
Sealfon SC, Weinstein H, Millar RP. Molecular mechanisms of ligand interaction with the gonadotropin- releasing hormone receptor Endocrine Reviews. 18: 180-205. PMID 9101136 DOI: 10.1210/Edrv.18.2.0295 |
0.346 |
|
| 1997 |
Pardo L, Weinstein H. On the structure and activity of membrane receptors: A computational simulation of ligand-triggered activation in a model 5-HT1A receptor International Journal of Quantum Chemistry. 63: 767-780. DOI: 10.1002/(Sici)1097-461X(1997)63:3<767::Aid-Qua17>3.0.Co;2-1 |
0.339 |
|
| 1996 |
Pardo L, Batlle M, Duñach M, Weinstein H. Structure and activity of membrane receptors: Modeling and computational simulation of ligand recognition in a three-dimensional model of the 5-hydroxytryptamine1A receptor Journal of Biomedical Science. 3: 98-107. PMID 11725090 DOI: 10.1007/Bf02255537 |
0.411 |
|
| 1996 |
Fu D, Ballesteros JA, Weinstein H, Chen J, Javitch JA. Residues in the seventh membrane-spanning segment of the dopamine D2 receptor accessible in the binding-site crevice. Biochemistry. 35: 11278-85. PMID 8784181 DOI: 10.1021/Bi960928X |
0.375 |
|
| 1996 |
Almaula N, Ebersole BJ, Zhang D, Weinstein H, Sealfon SC. Mapping the binding site pocket of the serotonin 5-hydroxytryptamine2A receptor: Ser3.36(159) provides a second interaction site for the protonated amine of serotonin but not of lysergic acid diethylamide or bufotenin Journal of Biological Chemistry. 271: 14672-14675. PMID 8663249 DOI: 10.1074/Jbc.271.25.14672 |
0.366 |
|
| 1996 |
Guarnieri F, Weinstein H. Conformational memories and the exploration of biologically relevant peptide conformations: An illustration for the gonadotropin-releasing hormone Journal of the American Chemical Society. 118: 5580-5589. DOI: 10.1021/Ja952745O |
0.311 |
|
| 1995 |
Gulati J, Akella AB, Su H, Mehler EL, Weinstein H. Functional role of arginine-11 in the N-terminal helix of skeletal troponin C: combined mutagenesis and molecular dynamics investigation. Biochemistry. 34: 7348-55. PMID 7779777 DOI: 10.1021/Bi00022A007 |
0.35 |
|
| 1995 |
Zhou W, Rodic V, Kitanovic S, Flanagan CA, Chi L, Weinstein H, Maayani S, Millar RP, Sealfon SC. A locus of the gonadotropin-releasing hormone receptor that differentiates agonist and antagonist binding sites. The Journal of Biological Chemistry. 270: 18853-7. PMID 7642539 DOI: 10.1074/Jbc.270.32.18853 |
0.349 |
|
| 1995 |
Sealfon SC, Chi L, Ebersole BJ, Rodic V, Zhang D, Ballesteros JA, Weinstein H. Related contribution of specific helix 2 and 7 residues to conformational activation of the serotonin 5-HT2A receptor Journal of Biological Chemistry. 270: 16683-16688. PMID 7622478 DOI: 10.1074/Jbc.270.28.16683 |
0.369 |
|
| 1995 |
Ballesteros JA, Weinstein H. [19] Integrated methods for the construction of three-dimensional models and computational probing of structure-function relations in G protein-coupled receptors Methods in Neurosciences. 25: 366-428. DOI: 10.1016/S1043-9471(05)80049-7 |
0.402 |
|
| 1994 |
Zhang D, Weinstein H. Polarity conserved positions in transmembrane domains of G-protein coupled receptors and bacteriorhodopsin Febs Letters. 337: 207-212. PMID 8287978 DOI: 10.1016/0014-5793(94)80274-2 |
0.368 |
|
| 1994 |
Luo X, Zhang D, Weinstein H. Ligand-induced domain motion in the activation mechanism of a G-protein-coupled receptor Protein Engineering. 7: 1441-1448. PMID 7716154 DOI: 10.1093/Protein/7.12.1441 |
0.406 |
|
| 1993 |
Zhang D, Weinstein H. Signal transduction by a 5-HT2 receptor: A mechanistic hypothesis from molecular dynamics simulations of the three-dimensional model of the receptor complexed to ligands Journal of Medicinal Chemistry. 36: 934-938. PMID 8464048 DOI: 10.1021/Jm00059A021 |
0.31 |
|
| 1993 |
Mehler EL, Kushick JN, Weinstein H. Consequences of Sequential Ca2+ Occupancy for the Structure and Dynamics of CalbindinD9K: Computational Simulations and Comparison to Experimental Determinations in Solution Molecular Simulation. 10: 309-334. DOI: 10.1080/08927029308022171 |
0.335 |
|
| 1993 |
Miaskiewicz K, Osman R, Weinstein H. Molecular dynamics simulation of the hydrated d(CGCGAATTCGCG)2 dodecamer Journal of the American Chemical Society. 115: 1526-1537. DOI: 10.1021/Ja00057A045 |
0.32 |
|
| 1992 |
Ballesteros JA, Weinstein H. Analysis and refinement of criteria for predicting the structure and relative orientations of transmembranal helical domains Biophysical Journal. 62: 107-109. PMID 1600090 DOI: 10.1016/S0006-3495(92)81794-0 |
0.398 |
|
| 1992 |
Pardo L, Ballesteros JA, Osman R, Weinstein H. On the use of the transmembrane domain of bacteriorhodopsin as a template for modeling the three-dimensional structure of guanine nucleotide-binding regulatory protein-coupled receptors. Proceedings of the National Academy of Sciences of the United States of America. 89: 4009-12. PMID 1315046 DOI: 10.1073/Pnas.89.9.4009 |
0.414 |
|
| 1991 |
Mehler EL, Pascual-Ahuir J, Weinstein H. Structural dynamics of calmodulin and troponin C. Protein Engineering. 4: 625-637. PMID 1946320 DOI: 10.1093/Protein/4.6.625 |
0.383 |
|
| 1991 |
Pascual-Ahuir J, Mehler EL, Weinstein H. Calmodulin structure and function: Implication of arginine in the compaction related to ligand binding Molecular Engineering. 1: 231-247. DOI: 10.1007/Bf00161666 |
0.404 |
|
| 1991 |
Haaksma E, Timmerman H, Weinstein H. The effect of a protein environment on the proposed activation mechanism of the histamine H2-receptor Israel Journal of Chemistry. 31: 409-421. DOI: 10.1002/Ijch.199100047 |
0.386 |
|
| 1988 |
Mercier GA, Osman R, Weinstein H. Role of primary and secondary protein structure in neurotransmitter receptor activation mechanisms Protein Engineering, Design and Selection. 2: 261-270. PMID 3074305 DOI: 10.1093/Protein/2.4.261 |
0.375 |
|
| 1986 |
Reggio P, Topiol S, Weinstein H. Molecular determinants for the agonist activity of 2-methylhistamine and 4-methylhistamine at H2-receptors Journal of Medicinal Chemistry. 29: 2412-2415. PMID 3783601 DOI: 10.1021/Jm00161A047 |
0.325 |
|
| 1985 |
Liebman MN, Venanzi CA, Weinstein H. Structural analysis of carboxypeptidase A and its complexes with inhibitors as a basis for modeling enzyme recognition and specificity. Biopolymers. 24: 1721-58. PMID 4052582 DOI: 10.1002/Bip.360240906 |
0.383 |
|
| 1985 |
Weinstein H, Rabinowitz J, Liebman MN, Osman R. Determinants of molecular reactivity as criteria for predicting toxicity: problems and approaches. Environmental Health Perspectives. 61: 147-162. PMID 3905371 DOI: 10.1289/Ehp.8561147 |
0.327 |
|
| 1984 |
Topiol S, Weinstein H, Osman R. A theoretical investigation of histamine tautomerism Journal of Medicinal Chemistry. 27: 1531-1533. PMID 6492081 DOI: 10.1021/Jm00377A023 |
0.315 |
|
| 1984 |
Mazurek AP, Weinstein H, Osman R, Topiol S, Ebersole BJ. Theoretical and experimental studies of drug–receptor interactions: Determinants for recognition of 5‐hydroxytryptamine analogs International Journal of Quantum Chemistry. 26: 183-194. DOI: 10.1002/Qua.560260719 |
0.313 |
|
| 1979 |
Kang S, Ernst L, Weinstein H, Osman R. [13C]NMR Chemical Shifts and Calculated Electronic Structures of Serotonin Congeners: Relation to Biological Activity Molecular Pharmacology. 16: 1031-1039. DOI: 10.1016/B978-0-08-023768-8.52245-3 |
0.343 |
|
| 1977 |
Weinstein H, Srebrenik S, Maayani S, Sokolovsky M. A theoretical model study of the comparative effectiveness of atropine and scopolamine action in the central nervous system. Journal of Theoretical Biology. 64: 295-309. PMID 839804 DOI: 10.1016/0022-5193(77)90358-7 |
0.355 |
|
| 1977 |
Weinstein H, Osman R. Models for molecular mechanisms in drug—receptor interactions. Serotonin and 5‐hydroxyindole complexes with imidazolium cation International Journal of Quantum Chemistry. 12: 253-268. DOI: 10.1002/Qua.560120726 |
0.339 |
|
| 1976 |
Chang S, Weinstein H, Chou D. Perturbation treatment of multiple site reactivity: Molecule–molecule interactions Chemical Physics Letters. 42: 145-150. DOI: 10.1016/0009-2614(76)80572-6 |
0.314 |
|
| 1975 |
Srebrenik S, Pauncz R, Weinstein H. Some definitions of atomic regions in molecules and solids Chemical Physics Letters. 32: 420-425. DOI: 10.1016/0009-2614(75)85206-7 |
0.702 |
|
| 1975 |
Weinstein H. Some new quantum chemical procedures for the analysis of drug—receptor interactions International Journal of Quantum Chemistry. 9: 59-69. DOI: 10.1002/Qua.560090706 |
0.333 |
|
| 1974 |
Srebrenik S, Weinstein H, Pauncz R. Formulation of molecular forces and their analytical calculation Journal of Chemical Physics. 61: 5050-5053. DOI: 10.1063/1.1681847 |
0.695 |
|
| 1973 |
Maayani S, Weinstein H, Cohen S, Sokolovsky M. Acetylcholine-Like Molecular Arrangement in Psychomimetic Anticholinergic Drugs Proceedings of the National Academy of Sciences of the United States of America. 70: 3103-3107. PMID 4522291 DOI: 10.1073/Pnas.70.11.3103 |
0.374 |
|
| 1973 |
Srebrenik S, Weinstein H, Pauncz R. Analytical calculation of atomic and molecular electrostatic potentials from the Poisson equation Chemical Physics Letters. 20: 419-423. DOI: 10.1016/0009-2614(73)85188-7 |
0.706 |
|
| 1972 |
Weinstein H, Pauncz R. Direct optimization approach to molecular electron density calculation Chemical Physics Letters. 14: 161-166. DOI: 10.1016/0009-2614(72)87169-0 |
0.709 |
|
| 1971 |
Weinstein H, Pauncz R, Cohen M. Localized Molecular Orbitals Advances in Atomic, Molecular and Optical Physics. 7: 97-140. DOI: 10.1016/S0065-2199(08)60359-0 |
0.71 |
|
| 1968 |
Weinstein H, Pauncz R. Molecular orbital set determined by a localization procedure Symposia of the Faraday Society. 2: 23-31. DOI: 10.1039/Sf9680200023 |
0.704 |
|
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