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Barry O'Keefe - Publications

Affiliations: 
1994-1996 Laboratory of Drug Discovery Research & Development National Cancer Institute, Rockville, MD, United States 
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35 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Du L, Wilson BAP, Li N, Shah R, Dalilian M, Wang D, Smith EA, Wamiru A, Goncharova EI, Zhang P, O'Keefe BR. Discovery and Synthesis of a Naturally Derived Protein Kinase Inhibitor that Selectively Inhibits Distinct Classes of Serine/Threonine Kinases. Journal of Natural Products. PMID 37843072 DOI: 10.1021/acs.jnatprod.3c00394  0.47
2023 Tian X, Wang D, Jiang W, Bokesch HR, Wilson BAP, O'Keefe BR, Gustafson KR. Rare Caulamidine Hexacyclic Alkaloids from the Marine Ascidian sp. Journal of Natural Products. PMID 37368408 DOI: 10.1021/acs.jnatprod.3c00393  0.4
2023 Wilson BAP, Li N, Martinez Fiesco JA, Dalilian M, Wang D, Smith EA, Wamiru A, Shah R, Goncharova EI, Beutler JA, Grkovic T, Zhang P, O'Keefe BR. Biochemical Discovery, Intracellular Evaluation, and Crystallographic Characterization of Synthetic and Natural Product Adenosine 3',5'-Cyclic Monophosphate-Dependent Protein Kinase A (PKA) Inhibitors. Acs Pharmacology & Translational Science. 6: 633-650. PMID 37082750 DOI: 10.1021/acsptsci.3c00010  0.623
2022 Jiang W, Tian X, Wang D, Bokesch HR, Thomas CL, Woldemichael GM, Gryder BE, Wei JS, Song YK, Chou HC, Khan J, O'Keefe BR, Gustafson KR. Dentithecamides A-H, Diacylated Zoanthoxanthin Derivatives with PAX3-FOXO1 Inhibitory Activity from the Hydroid . Journal of Natural Products. PMID 35465663 DOI: 10.1021/acs.jnatprod.2c00246  0.454
2021 Jiang W, Wang D, Wilson BAP, Kang U, Bokesch HR, Smith EA, Wamiru A, Goncharova EI, Voeller D, Lipkowitz S, O'Keefe BR, Gustafson KR. Agelasine Diterpenoids and Cbl-b Inhibitory Ageliferins from the Coralline Demosponge . Marine Drugs. 19. PMID 34202500 DOI: 10.3390/md19070361  0.473
2021 Jiang W, Wang D, Wilson BAP, Voeller D, Bokesch HR, Smith EA, Lipkowitz S, O'Keefe BR, Gustafson KR. Sinularamides A-G, Terpenoid-Derived Spermidine and Spermine Conjugates with Casitas B-Lineage Lymphoma Proto-Oncogene B (Cbl-b) Inhibitory Activities from a sp. Soft Coral. Journal of Natural Products. PMID 34038132 DOI: 10.1021/acs.jnatprod.1c00367  0.436
2021 Wang D, Jiang W, Kim CK, Bokesch HR, Woldemichael GM, Gryder BE, Shern JF, Khan J, O'Keefe BR, Beutler JA, Gustafson KR. Neopetrothiazide: An Intriguing Pentacyclic Thiazide Alkaloid from the Sponge sp. Organic Letters. PMID 33848174 DOI: 10.1021/acs.orglett.1c00743  0.555
2020 Kim CK, Wang D, Wilson BAP, Saurí J, Voeller D, Lipkowitz S, O'Keefe BR, Gustafson KR. Suberitamides A-C, Aryl Alkaloids from a sp. Marine Sponge that Inhibit Cbl-b Ubiquitin Ligase Activity. Marine Drugs. 18. PMID 33126420 DOI: 10.3390/md18110536  0.416
2019 He M, Grkovic T, Evans JR, Thornburg CC, Akee RK, Thompson JR, Whitt JA, Harris MJ, Loyal JA, Britt JR, Jia L, White JD, Newman DJ, O'Keefe BR. The NCI library of traditional Chinese medicinal plant extracts - Preliminary assessment of the NCI-60 activity and chemical profiling of selected species. Fitoterapia. 104285. PMID 31386897 DOI: 10.1016/J.Fitote.2019.104285  0.31
2019 Tran TD, Cartner LK, Bokesch HR, Henrich CJ, Wang XW, Mahidol C, Ruchirawat S, Kittakoop P, O'Keefe BR, Gustafson KR. NMR Characterization of Rearranged Staurosporine Aglycone Analogues from the Marine Sponge Damiria sp. Magnetic Resonance in Chemistry : Mrc. PMID 31379005 DOI: 10.1002/mrc.4932  0.325
2017 Jia L, Lin H, Oppenheim J, Howard OMZ, Li J, Fan H, Zhao Z, Farrar W, Zhang Y, Colburn N, Young MR, Li W, Newman D, O'Keefe BR, Beutler J, et al. US National Cancer Institute-China Collaborative Studies on Chinese Medicine and Cancer. Journal of the National Cancer Institute. Monographs. 2017. PMID 29140488 DOI: 10.1093/Jncimonographs/Lgx007  0.466
2016 Shaffer C, Cai S, Perez A, Risinger A, Du L, O'Keefe B, Cichewicz R, Mooberry S. Abstract P5-04-18: Extracts derived from fungi and plants demonstrate specificity for subtyptes of triple negative breast cancer Cancer Research. 76. DOI: 10.1158/1538-7445.Sabcs15-P5-04-18  0.395
2015 Espindola L, Wilson B, Beutler J, Gustafson K, O'Keefe B. Brazilian cerrado biome plant extract bank screening in inflammatory disease and cancer enzymes Planta Medica. 81. DOI: 10.1055/S-0035-1556521  0.531
2015 Thornburg C, Grkovic T, Britt J, Akee R, Whitt J, Evans J, Grothaus P, Collins J, O'Keefe B. Development of a natural product-based fraction library for improved performance in high-throughput screening systems Planta Medica. 81. DOI: 10.1055/S-0035-1556299  0.306
2015 Grkovic T, Akee R, Evans J, Collins J, O'Keefe B. Biologically active natural products from Cassine viburnifolia Planta Medica. 81. DOI: 10.1055/S-0035-1556259  0.301
2014 Hassig CA, Zeng FY, Kung P, Kiankarimi M, Kim S, Diaz PW, Zhai D, Welsh K, Morshedian S, Su Y, O'Keefe B, Newman DJ, Rusman Y, Kaur H, Salomon CE, et al. Ultra-High-Throughput Screening of Natural Product Extracts to Identify Proapoptotic Inhibitors of Bcl-2 Family Proteins. Journal of Biomolecular Screening. 19: 1201-1211. PMID 24870016 DOI: 10.1177/1087057114536227  0.422
2014 Bermingham A, Price E, Marchand C, Whitson E, Gustafson K, McMahon J, Pommier Y, O'Keefe B. A screen for the identification of inhibitors of tyrosyl-DNA phosphodiesterase 1 Planta Medica. 80. DOI: 10.1055/S-0034-1382735  0.305
2014 Chan S, Henrich C, O'Keefe B, McKee T, McMahon J, Gustafson K. Isolation and identification of biologically active natural products from marine ascidians Planta Medica. 80. DOI: 10.1055/S-0034-1382375  0.339
2013 Castro A, Smith E, Haugh Krumpe L, O'Keefe B, Staudt L, McMahon J, Gustafson K. Natural Product Inhibitors of the Arginine-Specific Protease Activity of MALT1 Planta Medica. 79. DOI: 10.1055/S-0033-1348633  0.352
2013 Divlianska D, Wright A, Francis S, Walters M, Salomon C, Diaz P, Hassig C, O'Keefe B, Reed J, Roth G. In Search of Novel Cancer Therapeutics: Assessing the NCI Natural Product Library against Ten Anti-Apoptotic Protein Targets Planta Medica. 79. DOI: 10.1055/S-0033-1348587  0.331
2010 Carpentieri A, Ratner DM, Ghosh SK, Banerjee S, Bushkin GG, Cui J, Lubrano M, Steffen M, Costello CE, O'Keefe B, Robbins PW, Samuelson J. The antiretroviral lectin cyanovirin-N targets well-known and novel targets on the surface of Entamoeba histolytica trophozoites. Eukaryotic Cell. 9: 1661-8. PMID 20852023 DOI: 10.1128/Ec.00166-10  0.317
2010 Chung S, Wendeler M, Rausch JW, Beilhartz G, Gotte M, O'Keefe BR, Bermingham A, Beutler JA, Liu S, Zhuang X, Le Grice SF. Structure-activity analysis of vinylogous urea inhibitors of human immunodeficiency virus-encoded ribonuclease H. Antimicrobial Agents and Chemotherapy. 54: 3913-21. PMID 20547794 DOI: 10.1128/Aac.00434-10  0.562
2010 Alexandre KB, Gray ES, Lambson BE, Moore PL, Choge IA, Mlisana K, Karim SS, McMahon J, O'Keefe B, Chikwamba R, Morris L. Mannose-rich glycosylation patterns on HIV-1 subtype C gp120 and sensitivity to the lectins, Griffithsin, Cyanovirin-N and Scytovirin. Virology. 402: 187-96. PMID 20392471 DOI: 10.1016/J.Virol.2010.03.021  0.376
2009 Bermingham A, Price E, Marchand C, Pommier Y, Goncharova K, Evans J, McMahon J, O'Keefe B. Abstract A174: High‐throughput screening for natural product inhibitors of human tyrosyl‐DNA‐phosphodiesterase (Tdp‐1) Molecular Cancer Therapeutics. 8. DOI: 10.1158/1535-7163.Targ-09-A174  0.429
2008 Weissman AM, Yang Y, Kitagaki J, Sasiela CA, Beutler JA, O'Keefe BR. Inhibiting Hdm2 and ubiquitin-activating enzyme: targeting the ubiquitin conjugating system in cancer. Ernst Schering Foundation Symposium Proceedings. 171-90. PMID 19202599  0.543
2008 Wendeler M, Lee HF, Bermingham A, Miller JT, Chertov O, Bona MK, Baichoo NS, Ehteshami M, Beutler J, O'Keefe BR, Götte M, Kvaratskhelia M, Le Grice S. Vinylogous ureas as a novel class of inhibitors of reverse transcriptase-associated ribonuclease H activity. Acs Chemical Biology. 3: 635-44. PMID 18831589 DOI: 10.1021/Cb8001039  0.561
2008 Sasiela CA, Stewart DH, Kitagaki J, Safiran YJ, Yang Y, Weissman AM, Oberoi P, Davydov IV, Goncharova E, Beutler JA, McMahon JB, O'Keefe BR. Identification of inhibitors for MDM2 ubiquitin ligase activity from natural product extracts by a novel high-throughput electrochemiluminescent screen. Journal of Biomolecular Screening. 13: 229-37. PMID 18270365 DOI: 10.1177/1087057108315038  0.559
2007 Takada K, Bermingham A, O'Keefe BR, Wamiru A, Beutler JA, Le Grice SF, Lloyd J, Gustafson KR, McMahon JB. An HIV RNase H inhibitory 1,3,4,5-tetragalloylapiitol from the African plant Hylodendron gabunensis. Journal of Natural Products. 70: 1647-9. PMID 17935297 DOI: 10.1021/Np0702279  0.562
2004 Bokesch HR, Charan RD, Meragelman KM, Beutler JA, Gardella R, O'Keefe BR, McKee TC, McMahon JB. Isolation and characterization of anti-HIV peptides from Dorstenia contrajerva and Treculia obovoidea. Febs Letters. 567: 287-90. PMID 15178338 DOI: 10.1016/J.Febslet.2004.04.085  0.547
2002 Beutler JA, McMahon JB, Johnson TR, O'Keefe BR, Buzzell RA, Robbins D, Gardella R, Wilson J, Boyd MR. High throughput screening for cyanovirin-N mimetics binding to HIV-1 gp41. Journal of Biomolecular Screening. 7: 105-10. PMID 12006108 DOI: 10.1177/108705710200700202  0.564
2000 Charan RD, Munro MH, O'Keefe BR, Sowder RCII, McKee TC, Currens MJ, Pannell LK, Boyd MR. Isolation and characterization of Myrianthus holstii lectin, a potent HIV-1 inhibitory protein from the plant Myrianthus holstii(1). Journal of Natural Products. 63: 1170-4. PMID 10978222 DOI: 10.1021/Np000039H  0.333
2000 McMahon JB, Beutler JA, O'Keefe BR, Goodrum CB, Myers MA, Boyd MR. Development of a cyanovirin-N-HIV-1 gp120 binding assay for high throughput screening of natural product extracts by time-resolved fluorescence. Journal of Biomolecular Screening. 5: 169-76. PMID 10894760 DOI: 10.1177/108705710000500309  0.571
1998 O'Keefe BR, Erim T, Beutler JA, Cardellina JH, Gulakowski RJ, Krepps BL, McMahon JB, Sowder RC, Johnson DG, Buckheit RW, Halliday S, Boyd MR. Isolation and characterization of adociavirin, a novel HIV-inhibitory protein from the sponge Adocia sp. Febs Letters. 431: 85-90. PMID 9684871 DOI: 10.1016/S0014-5793(98)00736-4  0.554
1997 O'Keefe BR, Beutler JA, Cardellina JH, Prather TR, Shoemaker RH, Sowder RC, Henderson LE, Pannell LK, Boyd MR. Isolation of a novel Kunitz family protease inhibitor in association with Tethya hemolysin from the sponge Tethya ingalli. Journal of Natural Products. 60: 1094-9. PMID 9392878 DOI: 10.1021/Np970242L  0.547
1997 O'Keefe BR, Beutler JA, Cardellina JH, Gulakowski RJ, Krepps BL, McMahon JB, Sowder RC, Henderson LE, Pannell LK, Pomponi SA, Boyd MR. Isolation and characterization of niphatevirin, a human-immunodeficiency-virus-inhibitory glycoprotein from the marine sponge Niphates erecta. European Journal of Biochemistry / Febs. 245: 47-53. PMID 9128723 DOI: 10.1111/J.1432-1033.1997.T01-1-00047.X  0.547
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