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Wolfgang Liedtke - Publications

Affiliations: 
Duke Medical School, Durham, NC, United States 
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105 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Savadipour A, Nims RJ, Rashidi N, Garcia-Castorena JM, Tang R, Marushack GK, Oswald SJ, Liedtke WB, Guilak F. Membrane stretch as the mechanism of activation of PIEZO1 ion channels in chondrocytes. Proceedings of the National Academy of Sciences of the United States of America. 120: e2221958120. PMID 37459546 DOI: 10.1073/pnas.2221958120  0.529
2023 Dicks AR, Maksaev GI, Harissa Z, Savadipour A, Tang R, Steward N, Liedtke W, Nichols CG, Wu CL, Guilak F. Skeletal dysplasia-causing TRPV4 mutations suppress the hypertrophic differentiation of human iPSC-derived chondrocytes. Elife. 12. PMID 36810131 DOI: 10.7554/eLife.71154  0.462
2023 Benítez-Angeles M, Romero AEL, Llorente I, Hernández-Araiza I, Vergara-Jaque A, Real FH, Castañeda ÓEG, Arciniega M, Morales-Buenrostro LE, Torres-Quiroz F, García-Villegas R, Tovar-Y-Romo LB, Liedtke WB, Islas LD, Rosenbaum T. Modes of action of lysophospholipids as endogenous activators of the TRPV4 ion channel. The Journal of Physiology. PMID 36625071 DOI: 10.1113/JP284262  0.312
2021 Willard VP, Leddy HA, Palmer D, Wu CL, Liedtke W, Guilak F. Transient receptor potential vanilloid 4 as a regulator of induced pluripotent stem cell chondrogenesis. Stem Cells (Dayton, Ohio). PMID 34427363 DOI: 10.1002/stem.3440  0.522
2021 Lee W, Nims RJ, Savadipour A, Zhang Q, Leddy HA, Liu F, McNulty AL, Chen Y, Guilak F, Liedtke WB. Inflammatory signaling sensitizes Piezo1 mechanotransduction in articular chondrocytes as a pathogenic feed-forward mechanism in osteoarthritis. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33758095 DOI: 10.1073/pnas.2001611118  0.77
2021 Nims RJ, Pferdehirt L, Ho NB, Savadipour A, Lorentz J, Sohi S, Kassab J, Ross AK, O'Conor CJ, Liedtke WB, Zhang B, McNulty AL, Guilak F. A synthetic mechanogenetic gene circuit for autonomous drug delivery in engineered tissues. Science Advances. 7. PMID 33571125 DOI: 10.1126/sciadv.abd9858  0.47
2020 Rosenkranz SC, Shaposhnykov A, Schnapauff O, Epping L, Vieira V, Heidermann K, Schattling B, Tsvilovskyy V, Liedtke W, Meuth SG, Freichel M, Gelderblom M, Friese MA. TRPV4-Mediated Regulation of the Blood Brain Barrier Is Abolished During Inflammation. Frontiers in Cell and Developmental Biology. 8: 849. PMID 32974355 DOI: 10.3389/Fcell.2020.00849  0.361
2020 Kuebler W, Jordt SE, Liedtke W. COVID-19: Urgent Reconsideration of Lung Edema as a Preventable Outcome: Inhibition of TRPV4 As a Promising and Feasible Approach. Ssrn. 3558887. PMID 32714108 DOI: 10.2139/ssrn.3558887  0.605
2020 Naik SK, Pattanaik K, Eich J, Sparr V, Hauptmann M, Kalsdorf B, Reiling N, Liedtke W, Kuebler WM, Schaible UE, Sonawane A. Differential Roles of the Calcium Ion Channel TRPV4 in Host Responses to Mycobacterium tuberculosis Early and Late in Infection. Iscience. 23: 101206. PMID 32535021 DOI: 10.1016/J.Isci.2020.101206  0.315
2020 Kuebler WM, Jordt SE, Liedtke WB. Urgent reconsideration of lung edema as a preventable outcome in COVID-19: Inhibition of TRPV4 represents a promising and feasible approach. American Journal of Physiology. Lung Cellular and Molecular Physiology. PMID 32401673 DOI: 10.1152/Ajplung.00161.2020  0.605
2020 Ottolini M, Hong K, Cope EL, Daneva Z, DeLalio LJ, Sokolowski JD, Marziano C, Nguyen NY, Altschmied J, Haendeler J, Johnstone SR, Kalani MY, Park MS, Patel RP, Liedtke W, et al. Local Peroxynitrite Impairs Endothelial TRPV4 Channels and Elevates Blood Pressure in Obesity. Circulation. PMID 32008372 DOI: 10.1161/Circulationaha.119.043385  0.342
2020 Swain SM, Romac JM, Shahid RA, Pandol SJ, Liedtke W, Vigna SR, Liddle RA. TRPV4 channel opening mediates pressure-induced pancreatitis initiated by Piezo1 activation. The Journal of Clinical Investigation. PMID 31999644 DOI: 10.1172/Jci134111  0.346
2019 Gilchrist CL, Leddy HA, Kaye L, Case ND, Rothenberg KE, Little D, Liedtke W, Hoffman BD, Guilak F. TRPV4-mediated calcium signaling in mesenchymal stem cells regulates aligned collagen matrix formation and vinculin tension. Proceedings of the National Academy of Sciences of the United States of America. PMID 30674675 DOI: 10.1073/Pnas.1811095116  0.558
2018 Ciura S, Prager-Khoutorsky M, Thirouin ZS, Wyrosdic JC, Olson JE, Liedtke W, Bourque CW. Trpv4 Mediates Hypotonic Inhibition of Central Osmosensory Neurons via Taurine Gliotransmission. Cell Reports. 23: 2245-2253. PMID 29791836 DOI: 10.1016/J.Celrep.2018.04.090  0.462
2017 Moore C, Gupta R, Jordt SE, Chen Y, Liedtke WB. Regulation of Pain and Itch by TRP Channels. Neuroscience Bulletin. PMID 29282613 DOI: 10.1007/S12264-017-0200-8  0.661
2017 Rodriguez E, Sakurai K, Xu J, Chen Y, Toda K, Zhao S, Han BX, Ryu D, Yin H, Liedtke W, Wang F. A craniofacial-specific monosynaptic circuit enables heightened affective pain. Nature Neuroscience. 20: 1734-1743. PMID 29184209 DOI: 10.1038/S41593-017-0012-1  0.316
2017 Lee W, Guilak F, Liedtke W. Role of Piezo Channels in Joint Health and Injury. Current Topics in Membranes. 79: 263-273. PMID 28728820 DOI: 10.1016/Bs.Ctm.2016.10.003  0.78
2017 Benemei S, De Logu F, Li Puma S, Marone IM, Coppi E, Ugolini F, Liedtke W, Pollastro F, Appendino G, Geppetti P, Materazzi S, Nassini R. The anti-migraine component of butterbur extracts, isopetasin, desensitizes peptidergic nociceptors by acting on TRPA1 cation channel. British Journal of Pharmacology. 174: 2897-2911. PMID 28622417 DOI: 10.1111/Bph.13917  0.355
2017 Chen Y, Moore CD, Zhang JY, Hall RP, MacLeod AS, Liedtke W. TRPV4 Moves toward Center-Fold in Rosacea Pathogenesis. The Journal of Investigative Dermatology. 137: 801-804. PMID 28340683 DOI: 10.1016/J.Jid.2016.12.013  0.385
2017 Michalick L, Erfinanda L, Weichelt U, van der Giet M, Liedtke W, Kuebler WM. Transient Receptor Potential Vanilloid 4 and Serum Glucocorticoid-regulated Kinase 1 Are Critical Mediators of Lung Injury in Overventilated Mice In Vivo. Anesthesiology. 126: 300-311. PMID 27861175 DOI: 10.1097/Aln.0000000000001443  0.371
2017 Erfinanda L, Lin Z, Gutbier B, Reppe K, Lienau J, Hocke A, Liedtke W, Witzenrath M, Kuebler WM. Loss of CFTR causes endothelial barrier failure in pneumonia via inhibition of WNK1 and TRPV4 activation European Respiratory Journal. 50. DOI: 10.1183/1393003.Congress-2017.Pa1874  0.355
2016 Seth RK, Das S, Dattaroy D, Chandrashekaran V, Alhasson F, Michelotti G, Nagarkatti M, Nagarkatti P, Diehl AM, Bell DP, Liedtke W, Chatterjee S. TRPV4 activation of endothelial nitric oxide synthase resists nonalcoholic fatty liver disease by blocking CYP2E1-mediated redox toxicity. Free Radical Biology & Medicine. PMID 27913210 DOI: 10.1016/J.Freeradbiomed.2016.11.047  0.34
2016 Kanju P, Liedtke W. Pleiotropic function of TRPV4 ion channels in the central nervous system. Experimental Physiology. 101: 1472-1476. PMID 27701788 DOI: 10.1113/Ep085790  0.438
2016 O'Conor CJ, Ramalingam S, Zelenski NA, Benefield HC, Rigo I, Little D, Wu CL, Chen D, Liedtke W, McNulty AL, Guilak F. Cartilage-Specific Knockout of the Mechanosensory Ion Channel TRPV4 Decreases Age-Related Osteoarthritis. Scientific Reports. 6: 29053. PMID 27388701 DOI: 10.1038/Srep29053  0.588
2016 Kanju P, Chen Y, Lee W, Yeo M, Lee SH, Romac J, Shahid R, Fan P, Gooden DM, Simon SA, Spasojevic I, Mook RA, Liddle RA, Guilak F, Liedtke WB. Small molecule dual-inhibitors of TRPV4 and TRPA1 for attenuation of inflammation and pain. Scientific Reports. 6: 26894. PMID 27247148 DOI: 10.1038/Srep26894  0.762
2016 Chen Y, Fang Q, Wang Z, Zhang JY, MacLeod AS, Hall RP, Liedtke WB. Transient receptor potential vanilloid 4 ion channel functions as a pruriceptor in epidermal keratinocytes to evoke histaminergic itch. The Journal of Biological Chemistry. PMID 26961876 DOI: 10.1074/jbc.M116.716464  0.338
2016 Lee W, Leddy H, McNulty A, Guilak F, Liedtke W. Inflammatory Cytokine Il-1α Up-Regulates Piezo1 and Hyper-Sensitizes Chondrocytes to Compression Biophysical Journal. 110: 349a. DOI: 10.1016/J.Bpj.2015.11.1878  0.768
2015 Rajasekhar P, Poole DP, Liedtke W, Bunnett NW, Veldhuis NA. P2Y1 Receptor Activation of the TRPV4 Ion Channel Enhances Purinergic Signaling in Satellite Glial Cells. The Journal of Biological Chemistry. 290: 29051-62. PMID 26475857 DOI: 10.1074/Jbc.M115.689729  0.454
2015 Zaelzer C, Hua P, Prager-Khoutorsky M, Ciura S, Voisin DL, Liedtke W, Bourque CW. ΔN-TRPV1: A Molecular Co-detector of Body Temperature and Osmotic Stress. Cell Reports. 13: 23-30. PMID 26387947 DOI: 10.1016/J.Celrep.2015.08.061  0.409
2015 Lin MT, Jian MY, Taylor MS, Cioffi DL, Yap FC, Liedtke W, Townsley MI. Functional coupling of TRPV4, IK, and SK channels contributes to Ca(2+)-dependent endothelial injury in rodent lung. Pulmonary Circulation. 5: 279-90. PMID 26064452 DOI: 10.1086/680166  0.436
2015 Cenac N, Bautzova T, Le Faouder P, Veldhuis NA, Poole DP, Rolland C, Bertrand J, Liedtke W, Dubourdeau M, Bertrand-Michel J, Zecchi L, Stanghellini V, Bunnett NW, Barbara G, Vergnolle N. Quantification and Potential Functions of Endogenous Agonists of Transient Receptor Potential Channels in Patients With Irritable Bowel Syndrome. Gastroenterology. 149: 433-44.e7. PMID 25911511 DOI: 10.1053/J.Gastro.2015.04.011  0.382
2015 Zhang Y, Chen Y, Liedtke W, Wang F. Lack of evidence for ectopic sprouting of genetically labeled Aβ touch afferents in inflammatory and neuropathic trigeminal pain. Molecular Pain. 11: 18. PMID 25880319 DOI: 10.1186/S12990-015-0017-2  0.311
2015 Zhao P, Lieu T, Barlow N, Sostegni S, Haerteis S, Korbmacher C, Liedtke W, Jimenez-Vargas NN, Vanner SJ, Bunnett NW. Neutrophil Elastase Activates Protease-activated Receptor-2 (PAR2) and Transient Receptor Potential Vanilloid 4 (TRPV4) to Cause Inflammation and Pain. The Journal of Biological Chemistry. 290: 13875-87. PMID 25878251 DOI: 10.1074/Jbc.M115.642736  0.416
2015 Zelenski NA, Leddy HA, Sanchez-Adams J, Zhang J, Bonaldo P, Liedtke W, Guilak F. Type VI Collagen Regulates Pericellular Matrix Properties, Chondrocyte Swelling, and Mechanotransduction in Mouse Articular Cartilage. Arthritis & Rheumatology (Hoboken, N.J.). 67: 1286-94. PMID 25604429 DOI: 10.1002/Art.39034  0.573
2015 McNulty AL, Leddy HA, Liedtke W, Guilak F. TRPV4 as a therapeutic target for joint diseases. Naunyn-Schmiedeberg's Archives of Pharmacology. 388: 437-50. PMID 25519495 DOI: 10.1007/S00210-014-1078-X  0.59
2014 Leddy HA, McNulty AL, Guilak F, Liedtke W. Unraveling the mechanism by which TRPV4 mutations cause skeletal dysplasias. Rare Diseases (Austin, Tex.). 2: e962971. PMID 26942100 DOI: 10.4161/2167549X.2014.962971  0.481
2014 Liedtke W. A precisely defined role for the tip link-associated protein TMIE in the mechanoelectrical transduction channel complex of inner ear hair cells. Neuron. 84: 889-91. PMID 25475183 DOI: 10.1016/J.Neuron.2014.11.015  0.3
2014 Lee W, Leddy HA, Chen Y, Lee SH, Zelenski NA, McNulty AL, Wu J, Beicker KN, Coles J, Zauscher S, Grandl J, Sachs F, Guilak F, Liedtke WB. Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage. Proceedings of the National Academy of Sciences of the United States of America. 111: E5114-22. PMID 25385580 DOI: 10.1073/Pnas.1414298111  0.772
2014 Chen Y, Kanju P, Fang Q, Lee SH, Parekh PK, Lee W, Moore C, Brenner D, Gereau RW, Wang F, Liedtke W. TRPV4 is necessary for trigeminal irritant pain and functions as a cellular formalin receptor. Pain. 155: 2662-72. PMID 25281928 DOI: 10.1016/J.Pain.2014.09.033  0.746
2014 Lindy AS, Parekh PK, Zhu R, Kanju P, Chintapalli SV, Tsvilovskyy V, Patterson RL, Anishkin A, van Rossum DB, Liedtke WB. TRPV channel-mediated calcium transients in nociceptor neurons are dispensable for avoidance behaviour. Nature Communications. 5: 4734. PMID 25178952 DOI: 10.1038/Ncomms5734  0.301
2014 Liedtke W, Zhang JY, Hall RP, Steinhoff M. Keratinocyte growth regulation TRP-ed up over downregulated TRPV4? The Journal of Investigative Dermatology. 134: 2310-2. PMID 25120148 DOI: 10.1038/Jid.2014.250  0.31
2014 Zhao P, Lieu T, Barlow N, Metcalf M, Veldhuis NA, Jensen DD, Kocan M, Sostegni S, Haerteis S, Baraznenok V, Henderson I, Lindström E, Guerrero-Alba R, Valdez-Morales EE, Liedtke W, et al. Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4. The Journal of Biological Chemistry. 289: 27215-34. PMID 25118282 DOI: 10.1074/Jbc.M114.599712  0.363
2014 Leddy HA, McNulty AL, Lee SH, Rothfusz NE, Gloss B, Kirby ML, Hutson MR, Cohn DH, Guilak F, Liedtke W. Follistatin in chondrocytes: the link between TRPV4 channelopathies and skeletal malformations. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 2525-37. PMID 24577120 DOI: 10.1096/Fj.13-245936  0.505
2014 O'Conor CJ, Leddy HA, Benefield HC, Liedtke WB, Guilak F. TRPV4-mediated mechanotransduction regulates the metabolic response of chondrocytes to dynamic loading. Proceedings of the National Academy of Sciences of the United States of America. 111: 1316-21. PMID 24474754 DOI: 10.1073/Pnas.1319569111  0.539
2014 Chen Y, Guilak F, Gereau IV RW, Wang F, Liedtke W. TRPV4-mediated trigeminal pain: behavior assessments and mechanisms Molecular Pain. 10: P1. DOI: 10.1186/1744-8069-10-S1-P1  0.574
2014 Chen Y, Wang F, Liedtke W. Modeling TMJD pain in the laboratory mouse: role of TRP ion channels Molecular Pain. 10: O8. DOI: 10.1186/1744-8069-10-S1-O8  0.438
2014 Lee W, Leddy H, Guilak F, Liedtke W. Characterization of Mechanotransensitivity of Articular Chondrocytes Biophysical Journal. 106: 389a-390a. DOI: 10.1016/J.Bpj.2013.11.2202  0.758
2013 Yeo M, Patisaul H, Liedtke W. Decoding the language of epigenetics during neural development is key for understanding development as well as developmental neurotoxicity. Epigenetics : Official Journal of the Dna Methylation Society. 8: 1128-32. PMID 24071811 DOI: 10.4161/Epi.26406  0.318
2013 Moore C, Cevikbas F, Pasolli HA, Chen Y, Kong W, Kempkes C, Parekh P, Lee SH, Kontchou NA, Yeh I, Ye I, Jokerst NM, Fuchs E, Steinhoff M, Liedtke WB. UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 signaling. Proceedings of the National Academy of Sciences of the United States of America. 110: E3225-34. PMID 23929777 DOI: 10.1073/Pnas.1312933110  0.357
2013 Xia Y, Fu Z, Hu J, Huang C, Paudel O, Cai S, Liedtke W, Sham JS. TRPV4 channel contributes to serotonin-induced pulmonary vasoconstriction and the enhanced vascular reactivity in chronic hypoxic pulmonary hypertension. American Journal of Physiology. Cell Physiology. 305: C704-15. PMID 23739180 DOI: 10.1152/Ajpcell.00099.2013  0.329
2013 Chen Y, Williams SH, McNulty AL, Hong JH, Lee SH, Rothfusz NE, Parekh PK, Moore C, Gereau RW, Taylor AB, Wang F, Guilak F, Liedtke W. Temporomandibular joint pain: a critical role for Trpv4 in the trigeminal ganglion. Pain. 154: 1295-304. PMID 23726674 DOI: 10.1016/J.Pain.2013.04.004  0.561
2013 Fariss MW, Gilmour MI, Reilly CA, Liedtke W, Ghio AJ. Emerging mechanistic targets in lung injury induced by combustion-generated particles. Toxicological Sciences : An Official Journal of the Society of Toxicology. 132: 253-67. PMID 23322347 DOI: 10.1093/Toxsci/Kft001  0.318
2013 Poole DP, Amadesi S, Veldhuis NA, Abogadie FC, Lieu T, Darby W, Liedtke W, Lew MJ, McIntyre P, Bunnett NW. Protease-activated receptor 2 (PAR2) protein and transient receptor potential vanilloid 4 (TRPV4) protein coupling is required for sustained inflammatory signaling. The Journal of Biological Chemistry. 288: 5790-802. PMID 23288842 DOI: 10.1074/Jbc.M112.438184  0.459
2013 Liedtke W, Yeo M, Zhang H, Wang Y, Gignac M, Miller S, Berglund K, Liu J. Highly conductive carbon nanotube matrix accelerates developmental chloride extrusion in central nervous system neurons by increased expression of chloride transporter KCC2. Small (Weinheim An Der Bergstrasse, Germany). 9: 1066-75. PMID 23229576 DOI: 10.1002/Smll.201201994  0.348
2013 O'Conor CJ, Griffin TM, Liedtke W, Guilak F. Increased susceptibility of Trpv4-deficient mice to obesity and obesity-induced osteoarthritis with very high-fat diet. Annals of the Rheumatic Diseases. 72: 300-4. PMID 23178209 DOI: 10.1136/Annrheumdis-2012-202272  0.513
2013 O'Conor C, Benefield H, Liedtke W, Guilak F. The transient receptor potential vanilloid 4 ion channel regulates the biosynthetic response of chondrocytes to dynamic loading Osteoarthritis and Cartilage. 21: S17-S18. DOI: 10.1016/J.Joca.2013.02.057  0.576
2012 Ye L, Kleiner S, Wu J, Sah R, Gupta RK, Banks AS, Cohen P, Khandekar MJ, Boström P, Mepani RJ, Laznik D, Kamenecka TM, Song X, Liedtke W, Mootha VK, et al. TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. Cell. 151: 96-110. PMID 23021218 DOI: 10.1016/J.Cell.2012.08.034  0.342
2012 Sonkusare SK, Bonev AD, Ledoux J, Liedtke W, Kotlikoff MI, Heppner TJ, Hill-Eubanks DC, Nelson MT. Elementary Ca2+ signals through endothelial TRPV4 channels regulate vascular function. Science (New York, N.Y.). 336: 597-601. PMID 22556255 DOI: 10.1126/Science.1216283  0.435
2012 Bourque CW, Guilak F, Liedtke W. A TRP that makes us feel hyper. The Journal of Physiology. 590: 1779-80. PMID 22532645 DOI: 10.1113/Jphysiol.2012.229187  0.458
2012 Yang XR, Lin AH, Hughes JM, Flavahan NA, Cao YN, Liedtke W, Sham JS. Upregulation of osmo-mechanosensitive TRPV4 channel facilitates chronic hypoxia-induced myogenic tone and pulmonary hypertension. American Journal of Physiology. Lung Cellular and Molecular Physiology. 302: L555-68. PMID 22207590 DOI: 10.1152/Ajplung.00005.2011  0.321
2012 Lange T, Princk M, Zhang Y, Pritschow BW, Teucher S, Liedtke W, Brinkmeier H. TRPV4 Channels in Mouse Skeletal Muscle: Gene Expression, Role for Ca2+ Homeostasis and Muscle Force and Fatigue Biophysical Journal. 102. DOI: 10.1016/J.Bpj.2011.11.1878  0.326
2011 Ciura S, Liedtke W, Bourque CW. Hypertonicity sensing in organum vasculosum lamina terminalis neurons: a mechanical process involving TRPV1 but not TRPV4. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 14669-76. PMID 21994383 DOI: 10.1523/Jneurosci.1420-11.2011  0.4
2011 Ryskamp DA, Witkovsky P, Barabas P, Huang W, Koehler C, Akimov NP, Lee SH, Chauhan S, Xing W, Rentería RC, Liedtke W, Krizaj D. The polymodal ion channel transient receptor potential vanilloid 4 modulates calcium flux, spiking rate, and apoptosis of mouse retinal ganglion cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 7089-101. PMID 21562271 DOI: 10.1523/Jneurosci.0359-11.2011  0.409
2011 Li J, Kanju P, Patterson M, Chew WL, Cho SH, Gilmour I, Oliver T, Yasuda R, Ghio A, Simon SA, Liedtke W. TRPV4-mediated calcium influx into human bronchial epithelia upon exposure to diesel exhaust particles. Environmental Health Perspectives. 119: 784-93. PMID 21245013 DOI: 10.1289/Ehp.1002807  0.346
2011 Pritschow BW, Lange T, Kasch J, Kunert-Keil C, Liedtke W, Brinkmeier H. Functional TRPV4 channels are expressed in mouse skeletal muscle and can modulate resting Ca2+ influx and muscle fatigue. Pflugers Archiv : European Journal of Physiology. 461: 115-22. PMID 20924600 DOI: 10.1007/S00424-010-0883-4  0.334
2011 Zaelzer CA, Hua P, Prager-Khoutorsky M, Ciura S, Lee S, Liedtke W, Bourque CW. TRPV1Δ1-283: A Candidate Osmoreceptor Channel Biophysical Journal. 100: 280a. DOI: 10.1016/J.Bpj.2010.12.1738  0.421
2010 Shukla AK, Kim J, Ahn S, Xiao K, Shenoy SK, Liedtke W, Lefkowitz RJ. Arresting a transient receptor potential (TRP) channel: beta-arrestin 1 mediates ubiquitination and functional down-regulation of TRPV4. The Journal of Biological Chemistry. 285: 30115-25. PMID 20650893 DOI: 10.1074/Jbc.M110.141549  0.393
2010 Clark AL, Votta BJ, Kumar S, Liedtke W, Guilak F. Chondroprotective role of the osmotically sensitive ion channel transient receptor potential vanilloid 4: age- and sex-dependent progression of osteoarthritis in Trpv4-deficient mice. Arthritis and Rheumatism. 62: 2973-83. PMID 20583100 DOI: 10.1002/Art.27624  0.589
2010 Hamanaka K, Jian MY, Townsley MI, King JA, Liedtke W, Weber DS, Eyal FG, Clapp MM, Parker JC. TRPV4 channels augment macrophage activation and ventilator-induced lung injury. American Journal of Physiology. Lung Cellular and Molecular Physiology. 299: L353-62. PMID 20562229 DOI: 10.1152/Ajplung.00315.2009  0.333
2010 Ceppa E, Cattaruzza F, Lyo V, Amadesi S, Pelayo JC, Poole DP, Vaksman N, Liedtke W, Cohen DM, Grady EF, Bunnett NW, Kirkwood KS. Transient receptor potential ion channels V4 and A1 contribute to pancreatitis pain in mice. American Journal of Physiology. Gastrointestinal and Liver Physiology. 299: G556-71. PMID 20539005 DOI: 10.1152/Ajpgi.00433.2009  0.42
2010 Guilak F, Leddy HA, Liedtke W. Transient receptor potential vanilloid 4: The sixth sense of the musculoskeletal system? Annals of the New York Academy of Sciences. 1192: 404-9. PMID 20392266 DOI: 10.1111/J.1749-6632.2010.05389.X  0.624
2010 Vergnolle N, Cenac N, Altier C, Cellars L, Chapman K, Zamponi GW, Materazzi S, Nassini R, Liedtke W, Cattaruzza F, Grady EF, Geppetti P, Bunnett NW. A role for transient receptor potential vanilloid 4 in tonicity-induced neurogenic inflammation. British Journal of Pharmacology. 159: 1161-73. PMID 20136846 DOI: 10.1111/J.1476-5381.2009.00590.X  0.376
2010 Fields WR, Liedtke W, Li J, Bombick B. Abstract 1693: Assessment of Nrf2 luciferase reporter assay and heme oxygenase expression as models of oxidative stress inin vitrocultures of lung cells exposed to cigarette smoke condensate Cancer Research. 70: 1693-1693. DOI: 10.1158/1538-7445.Am10-1693  0.305
2009 Phan MN, Leddy HA, Votta BJ, Kumar S, Levy DS, Lipshutz DB, Lee SH, Liedtke W, Guilak F. Functional characterization of TRPV4 as an osmotically sensitive ion channel in porcine articular chondrocytes. Arthritis and Rheumatism. 60: 3028-37. PMID 19790068 DOI: 10.1002/Art.24799  0.581
2009 Earley S, Pauyo T, Drapp R, Tavares MJ, Liedtke W, Brayden JE. TRPV4-dependent dilation of peripheral resistance arteries influences arterial pressure. American Journal of Physiology. Heart and Circulatory Physiology. 297: H1096-102. PMID 19617407 DOI: 10.1152/Ajpheart.00241.2009  0.357
2009 Wu S, Jian MY, Xu YC, Zhou C, Al-Mehdi AB, Liedtke W, Shin HS, Townsley MI. Ca2+ entry via alpha1G and TRPV4 channels differentially regulates surface expression of P-selectin and barrier integrity in pulmonary capillary endothelium. American Journal of Physiology. Lung Cellular and Molecular Physiology. 297: L650-7. PMID 19617313 DOI: 10.1152/Ajplung.00015.2009  0.405
2009 Guilak F, Cohen DM, Estes BT, Gimble JM, Liedtke W, Chen CS. Control of stem cell fate by physical interactions with the extracellular matrix. Cell Stem Cell. 5: 17-26. PMID 19570510 DOI: 10.1016/J.Stem.2009.06.016  0.455
2008 Liedtke W. Molecular mechanisms of TRPV4-mediated neural signaling. Annals of the New York Academy of Sciences. 1144: 42-52. PMID 19076362 DOI: 10.1196/Annals.1418.012  0.448
2008 Lorenzo IM, Liedtke W, Sanderson MJ, Valverde MA. TRPV4 channel participates in receptor-operated calcium entry and ciliary beat frequency regulation in mouse airway epithelial cells. Proceedings of the National Academy of Sciences of the United States of America. 105: 12611-6. PMID 18719094 DOI: 10.1073/Pnas.0803970105  0.429
2008 Simon SA, Liedtke W. How irritating: the role of TRPA1 in sensing cigarette smoke and aerogenic oxidants in the airways. The Journal of Clinical Investigation. 118: 2383-6. PMID 18568080 DOI: 10.1172/Jci36111  0.303
2008 Cenac N, Altier C, Chapman K, Liedtke W, Zamponi G, Vergnolle N. Transient Receptor Potential Vanilloid-4 Has a Major Role in Visceral Hypersensitivity Symptoms Gastroenterology. 135. PMID 18565335 DOI: 10.1053/J.Gastro.2008.05.024  0.41
2008 Brierley SM, Page AJ, Hughes PA, Adam B, Liebregts T, Cooper NJ, Holtmann G, Liedtke W, Blackshaw LA. Selective role for TRPV4 ion channels in visceral sensory pathways. Gastroenterology. 134: 2059-69. PMID 18343379 DOI: 10.1053/J.Gastro.2008.01.074  0.427
2008 Sipe WE, Brierley SM, Martin CM, Phillis BD, Cruz FB, Grady EF, Liedtke W, Cohen DM, Vanner S, Blackshaw LA, Bunnett NW. Transient receptor potential vanilloid 4 mediates protease activated receptor 2-induced sensitization of colonic afferent nerves and visceral hyperalgesia. American Journal of Physiology. Gastrointestinal and Liver Physiology. 294: G1288-98. PMID 18325985 DOI: 10.1152/Ajpgi.00002.2008  0.359
2008 Yin J, Hoffmann J, Kaestle SM, Neye N, Wang L, Baeurle J, Liedtke W, Wu S, Kuppe H, Pries AR, Kuebler WM. Negative-feedback loop attenuates hydrostatic lung edema via a cGMP-dependent regulation of transient receptor potential vanilloid 4. Circulation Research. 102: 966-74. PMID 18323527 DOI: 10.1161/Circresaha.107.168724  0.372
2008 Jian MY, King JA, Al-Mehdi AB, Liedtke W, Townsley MI. High vascular pressure-induced lung injury requires P450 epoxygenase-dependent activation of TRPV4. American Journal of Respiratory Cell and Molecular Biology. 38: 386-92. PMID 17962608 DOI: 10.1165/Rcmb.2007-0192Oc  0.328
2008 Leddy H, Phan M, Votta B, Kumar S, Lee S, Liedtke W, Guilak F. A6 FUNCTIONAL CHARACTERIZATION OF TRPV4 AS AN OSMOTICALLY SENSITIVE ION CHANNEL IN ARTICULAR CHONDROCYTES Osteoarthritis and Cartilage. 16: S15-S16. DOI: 10.1016/S1063-4584(08)60052-7  0.526
2008 Ceppa EP, Cattaruzza F, Amadesi S, Vaksman N, Grady E, Liedtke W, Bunnett NW, Kirkwood KS. 512 The Transient Receptor Potential (Trp) Ion Channels TRPA1 and TRPV4 Mediate Inflammatory Pain in the Pancreas Gastroenterology. 134. DOI: 10.1016/S0016-5085(08)60336-4  0.424
2008 Liedtke W. TRPV Ion Channels and Sensory Transduction of Osmotic and Mechanical Stimuli in Mammals [Sic]. 11: 85-100. DOI: 10.1007/978-3-540-72739-2_5  0.423
2007 Gevaert T, Vriens J, Segal A, Everaerts W, Roskams T, Talavera K, Owsianik G, Liedtke W, Daelemans D, Dewachter I, Van Leuven F, Voets T, De Ridder D, Nilius B. Deletion of the transient receptor potential cation channel TRPV4 impairs murine bladder voiding. The Journal of Clinical Investigation. 117: 3453-62. PMID 17948126 DOI: 10.1172/Jci31766  0.415
2007 Hartmannsgruber V, Heyken WT, Kacik M, Kaistha A, Grgic I, Harteneck C, Liedtke W, Hoyer J, Köhler R. Arterial response to shear stress critically depends on endothelial TRPV4 expression. Plos One. 2: e827. PMID 17786199 DOI: 10.1371/Journal.Pone.0000827  0.309
2007 Hamanaka K, Jian MY, Weber DS, Alvarez DF, Townsley MI, Al-Mehdi AB, King JA, Liedtke W, Parker JC. TRPV4 initiates the acute calcium-dependent permeability increase during ventilator-induced lung injury in isolated mouse lungs. American Journal of Physiology. Lung Cellular and Molecular Physiology. 293: L923-32. PMID 17660328 DOI: 10.1152/Ajplung.00221.2007  0.343
2007 Liu L, Chen L, Liedtke W, Simon SA. Changes in osmolality sensitize the response to capsaicin in trigeminal sensory neurons Journal of Neurophysiology. 97: 2001-2015. PMID 17353553 DOI: 10.1152/Jn.00887.2006  0.393
2007 Liedtke W. Role of TRPV ion channels in sensory transduction of osmotic stimuli in mammals. Experimental Physiology. 92: 507-12. PMID 17350992 DOI: 10.1113/Expphysiol.2006.035642  0.427
2007 Liedtke W. TRPV channels' role in osmotransduction and mechanotransduction. Handbook of Experimental Pharmacology. 179: 473-487. PMID 17217074 DOI: 10.1007/978-3-540-34891-7_28  0.424
2007 Grant AD, Cottrell GS, Amadesi S, Trevisani M, Nicoletti P, Materazzi S, Altier C, Cenac N, Zamponi GW, Bautista-Cruz F, Lopez CB, Joseph EK, Levine JD, Liedtke W, Vanner S, et al. Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice. The Journal of Physiology. 578: 715-33. PMID 17124270 DOI: 10.1113/Jphysiol.2006.121111  0.342
2006 Liedtke W. Transient receptor potential vanilloid channels functioning in transduction of osmotic stimuli. The Journal of Endocrinology. 191: 515-23. PMID 17170210 DOI: 10.1677/Joe.1.07000  0.419
2006 Alvarez DF, King JA, Weber D, Addison E, Liedtke W, Townsley MI. Transient receptor potential vanilloid 4-mediated disruption of the alveolar septal barrier: a novel mechanism of acute lung injury. Circulation Research. 99: 988-95. PMID 17008604 DOI: 10.1161/01.Res.0000247065.11756.19  0.395
2006 Liu X, Bandyopadhyay BC, Bandyopadhyay B, Nakamoto T, Singh B, Liedtke W, Melvin JE, Ambudkar I. A role for AQP5 in activation of TRPV4 by hypotonicity: concerted involvement of AQP5 and TRPV4 in regulation of cell volume recovery. The Journal of Biological Chemistry. 281: 15485-95. PMID 16571723 DOI: 10.1074/Jbc.M600549200  0.381
2005 Liedtke W, Kim C. Functionality of the TRPV subfamily of TRP ion channels: add mechano-TRP and osmo-TRP to the lexicon! Cellular and Molecular Life Sciences. 62: 2985-3001. PMID 16314934 DOI: 10.1007/S00018-005-5181-5  0.429
2005 Alessandri-Haber N, Joseph E, Dina OA, Liedtke W, Levine JD. TRPV4 mediates pain-related behavior induced by mild hypertonic stimuli in the presence of inflammatory mediator. Pain. 118: 70-9. PMID 16213085 DOI: 10.1016/J.Pain.2005.07.016  0.385
2005 Liedtke W. TRPV4 plays an evolutionary conserved role in the transduction of osmotic and mechanical stimuli in live animals. The Journal of Physiology. 567: 53-8. PMID 15961428 DOI: 10.1113/Jphysiol.2005.088963  0.452
2005 Liedtke W. TRPV4 as osmosensor: a transgenic approach. Pflugers Archiv : European Journal of Physiology. 451: 176-80. PMID 15952033 DOI: 10.1007/S00424-005-1449-8  0.43
2003 Liedtke W, Tobin DM, Bargmann CI, Friedman JM. Mammalian TRPV4 (VR-OAC) directs behavioral responses to osmotic and mechanical stimuli in Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America. 100: 14531-6. PMID 14581619 DOI: 10.1073/Pnas.2235619100  0.416
2003 Liedtke W, Friedman JM. Abnormal osmotic regulation in trpv4-/- mice. Proceedings of the National Academy of Sciences of the United States of America. 100: 13698-703. PMID 14581612 DOI: 10.1073/Pnas.1735416100  0.355
2000 Liedtke W, Choe Y, Martí-Renom MA, Bell AM, Denis CS, Sali A, Hudspeth AJ, Friedman JM, Heller S. Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor. Cell. 103: 525-35. PMID 11081638 DOI: 10.1016/S0092-8674(00)00143-4  0.422
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