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Hiro Furukawa - Publications

Affiliations: 
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 
Website:
https://www.cshl.edu/research/faculty-staff/hiro-furukawa/
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49 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Syrjänen JL, Epstein M, Gómez R, Furukawa H. Structure of human CALHM1 reveals key locations for channel regulation and blockade by ruthenium red. Nature Communications. 14: 3821. PMID 37380652 DOI: 10.1038/s41467-023-39388-3  0.826
2023 Harris LD, Regan MC, Myers SJ, Nocilla KA, Akins NS, Tahirovic YA, Wilson LJ, Dingledine R, Furukawa H, Traynelis SF, Liotta DC. Novel GluN2B-Selective NMDA Receptor Negative Allosteric Modulator Possesses Intrinsic Analgesic Properties and Enhances Analgesia of Morphine in a Rodent Tail Flick Pain Model. Acs Chemical Neuroscience. PMID 36779874 DOI: 10.1021/acschemneuro.2c00779  0.713
2022 Chou TH, Kang H, Simorowski N, Traynelis SF, Furukawa H. Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs. Molecular Cell. PMID 36309015 DOI: 10.1016/j.molcel.2022.10.008  0.806
2022 Yovanno RA, Chou TH, Brantley SJ, Furukawa H, Lau AY. Excitatory and inhibitory D-serine binding to the NMDA receptor. Elife. 11. PMID 36301074 DOI: 10.7554/eLife.77645  0.75
2022 Steigerwald R, Chou TH, Furukawa H, Wünsch B. GluN2A-selective NMDA receptor antagonists: Mimicking the U-shaped bioactive conformation of TCN-201 by a [2.2]paracyclophane system. Chemmedchem. PMID 36169098 DOI: 10.1002/cmdc.202200484  0.773
2022 Chou TH, Epstein M, Michalski K, Fine E, Biggin PC, Furukawa H. Structural insights into binding of therapeutic channel blockers in NMDA receptors. Nature Structural & Molecular Biology. 29: 507-518. PMID 35637422 DOI: 10.1038/s41594-022-00772-0  0.846
2022 Tajima N, Simorowski N, Yovanno RA, Regan MC, Michalski K, Gómez R, Lau AY, Furukawa H. Development and characterization of functional antibodies targeting NMDA receptors. Nature Communications. 13: 923. PMID 35177668 DOI: 10.1038/s41467-022-28559-3  0.802
2021 Hansen KB, Wollmuth LP, Bowie D, Furukawa H, Menniti FS, Sobolevsky AI, Swanson GT, Swanger SA, Greger IH, Nakagawa T, McBain CJ, Jayaraman V, Low CM, Dell'Acqua ML, Diamond JS, et al. Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels. Pharmacological Reviews. 73: 298-487. PMID 34753794 DOI: 10.1124/pharmrev.120.000131  0.849
2021 Furukawa H, Simorowski N, Michalski K. Effective production of oligomeric membrane proteins by EarlyBac-insect cell system. Methods in Enzymology. 653: 3-19. PMID 34099177 DOI: 10.1016/bs.mie.2020.12.019  0.736
2021 Syrjanen J, Michalski K, Kawate T, Furukawa H. On the molecular nature of large-pore channels. Journal of Molecular Biology. 166994. PMID 33865869 DOI: 10.1016/j.jmb.2021.166994  0.795
2021 Elegheert J, Cvetkovska V, Clayton AJ, Heroven C, Vennekens KM, Smukowski SN, Regan MC, Jia W, Smith AC, Furukawa H, Savas JN, de Wit J, Begbie J, Craig AM, Aricescu AR. Structural Mechanism for Modulation of Synaptic Neuroligin-Neurexin Signaling by MDGA Proteins. Neuron. 109: 189-190. PMID 33412094 DOI: 10.1016/j.neuron.2020.12.006  0.626
2020 Chou TH, Tajima N, Romero-Hernandez A, Furukawa H. Structural Basis of Functional Transitions in Mammalian NMDA Receptors. Cell. PMID 32610085 DOI: 10.1016/J.Cell.2020.05.052  0.831
2020 Perszyk RE, Myers SJ, Yuan H, Gibb AJ, Furukawa H, Sobolevsky AI, Traynelis SF. Hodgkin-huxley-katz prize lecture: genetic and pharmacological control of glutamate receptor channel through a highly conserved gating motif. The Journal of Physiology. PMID 32468591 DOI: 10.1113/Jp278086  0.825
2020 Syrjanen JL, Michalski K, Chou TH, Grant T, Rao S, Simorowski N, Tucker SJ, Grigorieff N, Furukawa H. Publisher Correction: Structure and assembly of calcium homeostasis modulator proteins. Nature Structural & Molecular Biology. PMID 32066965 DOI: 10.1038/S41594-020-0396-6  0.744
2020 Michalski K, Syrjanen JL, Henze E, Kumpf J, Furukawa H, Kawate T. The cryo-EM structure of a pannexin 1 reveals unique motifs for ion selection and inhibition. Elife. 9. PMID 32048993 DOI: 10.7554/Elife.54670  0.806
2020 Syrjanen JL, Michalski K, Chou TH, Grant T, Rao S, Simorowski N, Tucker SJ, Grigorieff N, Furukawa H. Structure and assembly of calcium homeostasis modulator proteins. Nature Structural & Molecular Biology. PMID 31988524 DOI: 10.1038/s41594-019-0369-9  0.781
2020 Wang JX, Irvine MW, Burnell ES, Sapkota K, Thatcher RJ, Li M, Simorowski N, Volianskis A, Collingridge GL, Monaghan DT, Jane DE, Furukawa H. Structural basis of subtype-selective competitive antagonism for GluN2C/2D-containing NMDA receptors. Nature Communications. 11: 423. PMID 31969570 DOI: 10.2210/Pdb6Uzg/Pdb  0.782
2020 Michalski K, Syrjanen JL, Henze E, Kumpf J, Furukawa H, Kawate T. Author response: The Cryo-EM structure of pannexin 1 reveals unique motifs for ion selection and inhibition Elife. DOI: 10.7554/Elife.54670.Sa2  0.768
2019 Wang JX, Furukawa H. Dissecting diverse functions of NMDA receptors by structural biology. Current Opinion in Structural Biology. 54: 34-42. PMID 30703613 DOI: 10.1016/J.Sbi.2018.12.009  0.667
2019 Regan MC, Zhu Z, Yuan H, Myers SJ, Menaldino DS, Tahirovic YA, Liotta DC, Traynelis SF, Furukawa H. Structural elements of a pH-sensitive inhibitor binding site in NMDA receptors. Nature Communications. 10: 321. PMID 30659174 DOI: 10.2210/Pdb6E7S/Pdb  0.794
2018 Hansen KB, Yi F, Perszyk RE, Furukawa H, Wollmuth LP, Gibb AJ, Traynelis SF. Structure, function, and allosteric modulation of NMDA receptors. The Journal of General Physiology. PMID 30037851 DOI: 10.1085/Jgp.201812032  0.824
2018 Wu Q, Regan M, Furukawa H, Jackson D. Role of heterotrimeric Gα proteins in maize development and enhancement of agronomic traits. Plos Genetics. 14: e1007374. PMID 29708966 DOI: 10.1371/Journal.Pgen.1007374  0.654
2018 Regan MC, Grant T, McDaniel MJ, Karakas E, Zhang J, Traynelis SF, Grigorieff N, Furukawa H. Structural Mechanism of Functional Modulation by Gene Splicing in NMDA Receptors. Neuron. PMID 29656875 DOI: 10.1016/J.Neuron.2018.03.034  0.864
2017 Elegheert J, Cvetkovska V, Clayton AJ, Heroven C, Vennekens KM, Smukowski SN, Regan MC, Jia W, Smith AC, Furukawa H, Savas JN, de Wit J, Begbie J, Craig AM, Aricescu AR. Structural Mechanism for Modulation of Synaptic Neuroligin-Neurexin Signaling by MDGA Proteins. Neuron. 96: 242-244. PMID 28957672 DOI: 10.1016/J.Neuron.2017.09.011  0.655
2017 Elegheert J, Cvetkovska V, Clayton AJ, Heroven C, Vennekens KM, Smukowski SN, Regan MC, Jia W, Smith AC, Furukawa H, Savas JN, de Wit J, Begbie J, Craig AM, Aricescu AR. Structural Mechanism for Modulation of Synaptic Neuroligin-Neurexin Signaling by MDGA Proteins. Neuron. 95: 896-913.e10. PMID 28817804 DOI: 10.1016/J.Neuron.2017.07.040  0.702
2017 Amin JB, Salussolia CL, Chan K, Regan MC, Dai J, Zhou HX, Furukawa H, Bowen ME, Wollmuth LP. Divergent roles of a peripheral transmembrane segment in AMPA and NMDA receptors. The Journal of General Physiology. PMID 28507080 DOI: 10.1085/Jgp.201711762  0.817
2017 Romero-Hernandez A, Furukawa H. Novel mode of antagonist binding in NMDA receptors revealed by the crystal structure of the GluN1-GluN2A ligand-binding domain complexed to NVP-AAM077. Molecular Pharmacology. PMID 28468946 DOI: 10.1124/Mol.116.107912  0.842
2016 Romero-Hernandez A, Simorowski N, Karakas E, Furukawa H. Molecular Basis for Subtype Specificity and High-Affinity Zinc Inhibition in the GluN1-GluN2A NMDA Receptor Amino-Terminal Domain. Neuron. PMID 27916457 DOI: 10.1016/J.Neuron.2016.11.006  0.852
2016 Regan MC, Furukawa H. Deeper Insights into the Allosteric Modulation of Ionotropic Glutamate Receptors. Neuron. 91: 1187-9. PMID 27657445 DOI: 10.1016/J.Neuron.2016.09.013  0.713
2016 Malinauskas T, Furukawa H. Production of Heteromeric Transmembrane Receptors with Defined Subunit Stoichiometry. Structure (London, England : 1993). 24: 1008-1009. PMID 27276428 DOI: 10.1016/J.Str.2016.05.003  0.741
2016 Malinauskas T, Furukawa H. Production of Heteromeric Transmembrane Receptors with Defined Subunit Stoichiometry. Structure (London, England : 1993). 24: 653-5. PMID 27145073 DOI: 10.1016/J.Str.2016.04.004  0.736
2016 Tajima N, Karakas E, Grant T, Simorowski N, Diaz-Avalos R, Grigorieff N, Furukawa H. Activation of NMDA receptors and the mechanism of inhibition by ifenprodil. Nature. PMID 27135925 DOI: 10.1038/Nature17679  0.86
2015 Regan MC, Romero-Hernandez A, Furukawa H. A structural biology perspective on NMDA receptor pharmacology and function. Current Opinion in Structural Biology. 33: 68-75. PMID 26282925 DOI: 10.1016/J.Sbi.2015.07.012  0.852
2015 Karakas E, Regan MC, Furukawa H. Emerging structural insights into the function of ionotropic glutamate receptors. Trends in Biochemical Sciences. 40: 328-37. PMID 25941168 DOI: 10.1016/J.Tibs.2015.04.002  0.846
2014 Khatri A, Burger PB, Swanger SA, Hansen KB, Zimmerman S, Karakas E, Liotta DC, Furukawa H, Snyder JP, Traynelis SF. Structural determinants and mechanism of action of a GluN2C-selective NMDA receptor positive allosteric modulator. Molecular Pharmacology. 86: 548-60. PMID 25205677 DOI: 10.1124/Mol.114.094516  0.81
2014 Karakas E, Furukawa H. Crystal structure of a heterotetrameric NMDA receptor ion channel. Science (New York, N.Y.). 344: 992-7. PMID 24876489 DOI: 10.1126/Science.1251915  0.776
2014 Jespersen A, Tajima N, Fernandez-Cuervo G, Garnier-Amblard EC, Furukawa H. Structural insights into competitive antagonism in NMDA receptors. Neuron. 81: 366-78. PMID 24462099 DOI: 10.1016/J.Neuron.2013.11.033  0.794
2013 Salussolia CL, Gan Q, Kazi R, Singh P, Allopenna J, Furukawa H, Wollmuth LP. A eukaryotic specific transmembrane segment is required for tetramerization in AMPA receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 9840-5. PMID 23739980 DOI: 10.1523/Jneurosci.2626-12.2013  0.775
2013 Hansen KB, Tajima N, Risgaard R, Perszyk RE, Jørgensen L, Vance KM, Ogden KK, Clausen RP, Furukawa H, Traynelis SF. Structural determinants of agonist efficacy at the glutamate binding site of N-methyl-D-aspartate receptors. Molecular Pharmacology. 84: 114-27. PMID 23625947 DOI: 10.1124/Mol.113.085803  0.861
2012 Burger PB, Yuan H, Karakas E, Geballe M, Furukawa H, Liotta DC, Snyder JP, Traynelis SF. Mapping the binding of GluN2B-selective N-methyl-D-aspartate receptor negative allosteric modulators. Molecular Pharmacology. 82: 344-59. PMID 22596351 DOI: 10.1124/Mol.112.078568  0.76
2012 Furukawa H. Structure and function of glutamate receptor amino terminal domains. The Journal of Physiology. 590: 63-72. PMID 22106178 DOI: 10.1113/Jphysiol.2011.213850  0.553
2012 Furukawa H. Structural Dissection of NMDA Receptor Pharmacology Biophysical Journal. 102: 418a. DOI: 10.1016/J.Bpj.2011.11.2287  0.591
2011 Karakas E, Simorowski N, Furukawa H. Subunit arrangement and phenylethanolamine binding in GluN1/GluN2B NMDA receptors. Nature. 475: 249-53. PMID 21677647 DOI: 10.1038/Nature10180  0.785
2011 Vance KM, Simorowski N, Traynelis SF, Furukawa H. Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors. Nature Communications. 2: 294. PMID 21522138 DOI: 10.1038/Ncomms1295  0.709
2010 Hansen KB, Furukawa H, Traynelis SF. Control of assembly and function of glutamate receptors by the amino-terminal domain. Molecular Pharmacology. 78: 535-49. PMID 20660085 DOI: 10.1124/Mol.110.067157  0.725
2010 Karakas E, Simorowski N, Furukawa H. Structural Insights into Allosteric Modulation of NMDA Receptors Through the Amino-Terminal Domain Biophysical Journal. 98: 609a. DOI: 10.1016/J.Bpj.2009.12.3322  0.779
2009 Karakas E, Simorowski N, Furukawa H. Structure of the zinc-bound amino-terminal domain of the NMDA receptor NR2B subunit. The Embo Journal. 28: 3910-20. PMID 19910922 DOI: 10.1038/Emboj.2009.338  0.785
2007 Vásquez V, Cortes DM, Furukawa H, Perozo E. An optimized purification and reconstitution method for the MscS channel: strategies for spectroscopical analysis. Biochemistry. 46: 6766-73. PMID 17500538 DOI: 10.1021/Bi700322K  0.386
2000 Furukawa H, Haga T, Muto Y, Yokoyama S, Hamada T, Hirota H. Conformation of Methacholine Bound to the Muscarinic Receptor Seibutsu Butsuri. 40: S22. DOI: 10.2142/Biophys.40.S22_3  0.466
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